| Year |
Citation |
Score |
| 2023 |
Weeks R, Ostermeier M. Fitness and functional landscapes of the E. coli RNase III gene rnc. Molecular Biology and Evolution. PMID 36848192 DOI: 10.1093/molbev/msad047 |
0.305 |
|
| 2020 |
Mehlhoff JD, Ostermeier M. Biological fitness landscapes by deep mutational scanning. Methods in Enzymology. 643: 203-224. PMID 32896282 DOI: 10.1016/Bs.Mie.2020.04.023 |
0.311 |
|
| 2020 |
Mehlhoff JD, Stearns FW, Rohm D, Wang B, Tsou EY, Dutta N, Hsiao MH, Gonzalez CE, Rubin AF, Ostermeier M. Collateral fitness effects of mutations. Proceedings of the National Academy of Sciences of the United States of America. PMID 32385156 DOI: 10.1073/Pnas.1918680117 |
0.802 |
|
| 2019 |
Ribeiro LFC, Chelius C, Boppidi KR, Naik NS, Hossain S, Ramsey JJJ, Kumar J, Ribeiro LF, Ostermeier M, Tran B, Ah Goo Y, de Assis LJ, Ulas M, Bayram O, Goldman GH, et al. Comprehensive Analysis of Aspergillus nidulans PKA Phosphorylome Identifies a Novel Mode of CreA Regulation. Mbio. 10. PMID 31040248 DOI: 10.1128/Mbio.02825-18 |
0.331 |
|
| 2019 |
Gonzalez CE, Roberts P, Ostermeier M. Fitness Effects of Single Amino Acid Insertions and Deletions in TEM-1 β-Lactamase. Journal of Molecular Biology. PMID 31034887 DOI: 10.1016/J.Jmb.2019.04.030 |
0.788 |
|
| 2019 |
Warren TD, Patel K, Eshleman JR, Ostermeier M. Protein-programmed accumulation of yeast cytosine deaminase in cancer cells in response to mock-hypoxia. Acs Synthetic Biology. PMID 30998310 DOI: 10.1021/Acssynbio.9B00036 |
0.792 |
|
| 2019 |
Gonzalez CE, Ostermeier M. Pervasive Pairwise Intragenic Epistasis among Sequential Mutations in TEM-1 β-Lactamase. Journal of Molecular Biology. PMID 30922874 DOI: 10.1016/J.Jmb.2019.03.020 |
0.774 |
|
| 2019 |
Warren TD, Patel K, Rivera JL, Eshleman JR, Ostermeier M. Comprehensive mutagenesis on yeast cytosine deaminase yields improvements in 5‐fluorocytosine toxicity in HT1080 cells Aiche Journal. 66. DOI: 10.1002/Aic.16688 |
0.744 |
|
| 2018 |
Xiong T, Rohm D, Workman RE, Roundtree L, Novina CD, Timp W, Ostermeier M. Protein engineering strategies for improving the selective methylation of target CpG sites by a dCas9-directed cytosine methyltransferase in bacteria. Plos One. 13: e0209408. PMID 30562388 DOI: 10.1371/Journal.Pone.0209408 |
0.798 |
|
| 2018 |
Ko C, Ostermeier M, Lin S. Dual column approach for the purification of zinc finger proteins by immobilized metal affinity chromatography Process Biochemistry. 73: 204-210. DOI: 10.1016/J.Procbio.2018.08.025 |
0.353 |
|
| 2017 |
Xiong T, Meister GE, Workman RE, Kato NC, Spellberg MJ, Turker F, Timp W, Ostermeier M, Novina CD. Targeted DNA methylation in human cells using engineered dCas9-methyltransferases. Scientific Reports. 7: 6732. PMID 28751638 DOI: 10.1038/S41598-017-06757-0 |
0.77 |
|
| 2017 |
Ribeiro LF, Warren TD, Ostermeier M. Construction of Protein Switches by Domain Insertion and Directed Evolution. Methods in Molecular Biology (Clifton, N.J.). 1596: 43-55. PMID 28293879 DOI: 10.1007/978-1-4939-6940-1_3 |
0.79 |
|
| 2016 |
Shelat NY, Parhi S, Ostermeier M. Development of a cancer-marker activated enzymatic switch from the herpes simplex virus thymidine kinase. Protein Engineering, Design & Selection : Peds. PMID 27986921 DOI: 10.1093/Protein/Gzw067 |
0.788 |
|
| 2016 |
Hauk P, Stephens K, Mckay R, Virgile CR, Ueda H, Ostermeier M, Ryu KS, Sintim HO, Bentley WE. Insightful directed evolution of Escherichia coli quorum sensing promoter region of the lsrACDBFG operon: a tool for synthetic biology systems and protein expression. Nucleic Acids Research. 44: 10515-10525. PMID 27915294 DOI: 10.1093/Nar/Gkw981 |
0.415 |
|
| 2016 |
Shelat NY, Parhi S, Ostermeier M. A Positive Selection for Nucleoside Kinases in E. coli. Plos One. 11: e0162921. PMID 27677184 DOI: 10.1371/Journal.Pone.0162921 |
0.77 |
|
| 2016 |
Ribeiro LF, Tullman J, Nicholes N, Silva SR, Vieira DS, Ostermeier M, Ward RJ. A xylose-stimulated xylanase-xylose binding protein chimera created by random nonhomologous recombination. Biotechnology For Biofuels. 9: 119. PMID 27274356 DOI: 10.1186/S13068-016-0529-7 |
0.781 |
|
| 2016 |
Choi JH, Xiong T, Ostermeier M. The interplay between effector binding and allostery in an engineered protein switch. Protein Science : a Publication of the Protein Society. PMID 27272021 DOI: 10.1002/Pro.2962 |
0.816 |
|
| 2016 |
Steinberg B, Ostermeier M. Shifting fitness and epistatic landscapes reflect tradeoffs along an evolutionary pathway. Journal of Molecular Biology. PMID 27173379 DOI: 10.1016/J.Jmb.2016.04.033 |
0.651 |
|
| 2016 |
Firnberg E, Labonte JW, Gray JJ, Ostermeier M. A Comprehensive, High-Resolution Map of a Gene's Fitness Landscape. Molecular Biology and Evolution. PMID 26912810 DOI: 10.1093/Molbev/Msw021 |
0.757 |
|
| 2016 |
Steinberg B, Ostermeier M. Environmental changes bridge evolutionary valleys. Science Advances. 2: e1500921. PMID 26844293 DOI: 10.1126/Sciadv.1500921 |
0.619 |
|
| 2016 |
Nicholes N, Date A, Beaujean P, Hauk P, Kanwar M, Ostermeier M. Modular protein switches derived from antibody mimetic proteins. Protein Engineering, Design & Selection : Peds. 29: 77-85. PMID 26637825 DOI: 10.1093/Protein/Gzv062 |
0.818 |
|
| 2015 |
Tullman J, Nicholes N, Dumont MR, Ribeiro LF, Ostermeier M. Enzymatic protein switches built from paralogous input domains. Biotechnology and Bioengineering. PMID 26461040 DOI: 10.1002/Bit.25852 |
0.802 |
|
| 2015 |
Ribeiro LF, Nicholes N, Tullman J, Ribeiro LF, Fuzo CA, Vieira DS, Furtado GP, Ostermeier M, Ward RJ. Insertion of a xylanase in xylose binding protein results in a xylose-stimulated xylanase. Biotechnology For Biofuels. 8: 118. PMID 26279676 DOI: 10.1186/S13068-015-0293-0 |
0.773 |
|
| 2015 |
Choi JH, Zayats M, Searson PC, Ostermeier M. Electrochemical activation of engineered protein switches. Biotechnology and Bioengineering. PMID 26241391 DOI: 10.1002/Bit.25720 |
0.371 |
|
| 2015 |
Choi JH, Laurent AH, Hilser VJ, Ostermeier M. Design of protein switches based on an ensemble model of allostery. Nature Communications. 6: 6968. PMID 25902417 DOI: 10.1038/Ncomms7968 |
0.397 |
|
| 2015 |
Cheung LS, Shea DJ, Nicholes N, Date A, Ostermeier M, Konstantopoulos K. Characterization of monobody scaffold interactions with ligand via force spectroscopy and steered molecular dynamics. Scientific Reports. 5: 8247. PMID 25650239 DOI: 10.1038/Srep08247 |
0.787 |
|
| 2015 |
Choi JH, Ostermeier M. Rational design of a fusion protein to exhibit disulfide-mediated logic gate behavior. Acs Synthetic Biology. 4: 400-6. PMID 25144732 DOI: 10.1021/Sb500254G |
0.382 |
|
| 2014 |
Wright RC, Khakhar A, Eshleman JR, Ostermeier M. Advancements in the development of HIF-1α-activated protein switches for use in enzyme prodrug therapy. Plos One. 9: e114032. PMID 25426963 DOI: 10.1371/Journal.Pone.0114032 |
0.52 |
|
| 2014 |
Chaikind B, Ostermeier M. Directed evolution of improved zinc finger methyltransferases. Plos One. 9: e96931. PMID 24810747 DOI: 10.1371/Journal.Pone.0096931 |
0.795 |
|
| 2014 |
Firnberg E, Labonte JW, Gray JJ, Ostermeier M. A comprehensive, high-resolution map of a gene's fitness landscape. Molecular Biology and Evolution. 31: 1581-92. PMID 24567513 DOI: 10.1093/Molbev/Msu081 |
0.796 |
|
| 2014 |
Chaikind B, Kilambi KP, Gray JJ, Ostermeier M. Correction: Targeted dna methylation using an artificially bisected m.hhai fused to zinc fingers (PLoS ONE) Plos One. 9. DOI: 10.1371/Annotation/B1F48851-2Dd7-438F-938E-6Bac0B4D8C94 |
0.756 |
|
| 2013 |
Firnberg E, Ostermeier M. The genetic code constrains yet facilitates Darwinian evolution. Nucleic Acids Research. 41: 7420-8. PMID 23754851 DOI: 10.1093/Nar/Gkt536 |
0.78 |
|
| 2013 |
Kanwar M, Wright RC, Date A, Tullman J, Ostermeier M. Protein switch engineering by domain insertion. Methods in Enzymology. 523: 369-88. PMID 23422439 DOI: 10.1016/B978-0-12-394292-0.00017-5 |
0.815 |
|
| 2013 |
Choi JH, San A, Ostermeier M. Non-allosteric enzyme switches possess larger effector-induced changes in thermodynamic stability than their non-switch analogs. Protein Science : a Publication of the Protein Society. 22: 475-85. PMID 23400970 DOI: 10.1002/Pro.2234 |
0.454 |
|
| 2012 |
Firnberg E, Ostermeier M. PFunkel: efficient, expansive, user-defined mutagenesis. Plos One. 7: e52031. PMID 23284860 DOI: 10.1371/Journal.Pone.0052031 |
0.799 |
|
| 2012 |
Chaikind B, Kilambi KP, Gray JJ, Ostermeier M. Targeted DNA Methylation Using an Artificially Bisected M.HhaI Fused to Zinc Fingers Plos One. 7. PMID 22984575 DOI: 10.1371/Journal.Pone.0044852 |
0.798 |
|
| 2012 |
Ke W, Laurent AH, Armstrong MD, Chen Y, Smith WE, Liang J, Wright CM, Ostermeier M, van den Akker F. Structure of an engineered β-lactamase maltose binding protein fusion protein: insights into heterotropic allosteric regulation. Plos One. 7: e39168. PMID 22720063 DOI: 10.1371/Journal.Pone.0039168 |
0.551 |
|
| 2012 |
Guntas G, Kanwar M, Ostermeier M. Circular permutation in the Ω-loop of TEM-1 β-lactamase results in improved activity and altered substrate specificity. Plos One. 7: e35998. PMID 22536452 DOI: 10.1371/Journal.Pone.0035998 |
0.804 |
|
| 2012 |
Cheung LS, Kanwar M, Ostermeier M, Konstantopoulos K. A hot-spot motif characterizes the interface between a designed ankyrin-repeat protein and its target ligand. Biophysical Journal. 102: 407-16. PMID 22325262 DOI: 10.1016/J.Bpj.2012.01.004 |
0.709 |
|
| 2011 |
Heins RA, Choi JH, Sohka T, Ostermeier M. In vitro recombination of non-homologous genes can result in gene fusions that confer a switching phenotype to cells. Plos One. 6: e27302. PMID 22096548 DOI: 10.1371/Journal.Pone.0027302 |
0.821 |
|
| 2011 |
Wright CM, Wright RC, Eshleman JR, Ostermeier M. A protein therapeutic modality founded on molecular regulation. Proceedings of the National Academy of Sciences of the United States of America. 108: 16206-11. PMID 21930952 DOI: 10.1073/Pnas.1102803108 |
0.516 |
|
| 2011 |
Tullman J, Guntas G, Dumont M, Ostermeier M. Protein switches identified from diverse insertion libraries created using S1 nuclease digestion of supercoiled-form plasmid DNA. Biotechnology and Bioengineering. 108: 2535-43. PMID 21618478 DOI: 10.1002/Bit.23224 |
0.805 |
|
| 2011 |
Zayats M, Kanwar M, Ostermeier M, Searson PC. Surface-tethered protein switches. Chemical Communications (Cambridge, England). 47: 3398-400. PMID 21331440 DOI: 10.1039/C1Cc10146C |
0.693 |
|
| 2011 |
Wright CM, Ostermeier M, Eshleman JR. Abstract 536: A hypoxia-activated protein switch as a potential anticancer therapeutic Cancer Research. 71: 536-536. DOI: 10.1158/1538-7445.Am2011-536 |
0.345 |
|
| 2011 |
Zayats M, Kanwar M, Ostermeier M, Searson PC. Molecular imprinting of maltose binding protein: Tuning protein recognition at the molecular level Macromolecules. 44: 3966-3972. DOI: 10.1021/Ma200355J |
0.704 |
|
| 2010 |
Hida K, Won SY, Di Pasquale G, Hanes J, Chiorini JA, Ostermeier M. Sites in the AAV5 capsid tolerant to deletions and tandem duplications. Archives of Biochemistry and Biophysics. 496: 1-8. PMID 20102698 DOI: 10.1016/J.Abb.2010.01.009 |
0.678 |
|
| 2010 |
Wright CM, Majumdar A, Tolman JR, Ostermeier M. NMR characterization of an engineered domain fusion between maltose binding protein and TEM1 beta-lactamase provides insight into its structure and allosteric mechanism. Proteins. 78: 1423-30. PMID 20034108 DOI: 10.1002/Prot.22657 |
0.37 |
|
| 2010 |
Meister GE, Chandrasegaran S, Ostermeier M. Heterodimeric DNA methyltransferases as a platform for creating designer zinc finger methyltransferases for targeted DNA methylation in cells. Nucleic Acids Research. 38: 1749-59. PMID 20007601 DOI: 10.1093/Nar/Gkp1126 |
0.792 |
|
| 2009 |
Kim CS, Pierre B, Ostermeier M, Looger LL, Kim JR. Enzyme stabilization by domain insertion into a thermophilic protein. Protein Engineering, Design & Selection : Peds. 22: 615-23. PMID 19622545 DOI: 10.1093/Protein/Gzp044 |
0.369 |
|
| 2009 |
Sohka T, Heins RA, Ostermeier M. Morphogen-defined patterning of Escherichia coli enabled by an externally tunable band-pass filter. Journal of Biological Engineering. 3: 10. PMID 19586541 DOI: 10.1186/1754-1611-3-10 |
0.751 |
|
| 2009 |
Sohka T, Heins RA, Phelan RM, Greisler JM, Townsend CA, Ostermeier M. An externally tunable bacterial band-pass filter. Proceedings of the National Academy of Sciences of the United States of America. 106: 10135-40. PMID 19502423 DOI: 10.1073/Pnas.0901246106 |
0.772 |
|
| 2009 |
Ostermeier M. Designing switchable enzymes. Current Opinion in Structural Biology. 19: 442-8. PMID 19473830 DOI: 10.1016/J.Sbi.2009.04.007 |
0.302 |
|
| 2009 |
Wright CM, Eshleman JR, Ostermeier M. Abstract C245: Protein switches that activate a prodrug in the presence of HIF‐1α Molecular Cancer Therapeutics. 8: 3851-3851. DOI: 10.1158/1535-7163.Targ-09-C245 |
0.43 |
|
| 2008 |
Meister GE, Chandrasegaran S, Ostermeier M. An engineered split M.HhaI-zinc finger fusion lacks the intended methyltransferase specificity. Biochemical and Biophysical Research Communications. 377: 226-30. PMID 18835252 DOI: 10.1016/J.Bbrc.2008.09.099 |
0.799 |
|
| 2008 |
Berrondo M, Ostermeier M, Gray JJ. Structure Prediction of Domain Insertion Proteins from Structures of Individual Domains Structure. 16: 513-527. PMID 18400174 DOI: 10.1016/J.Str.2008.01.012 |
0.782 |
|
| 2007 |
Hida K, Hanes J, Ostermeier M. Directed evolution for drug and nucleic acid delivery. Advanced Drug Delivery Reviews. 59: 1562-78. PMID 17933418 DOI: 10.1016/J.Addr.2007.08.022 |
0.664 |
|
| 2007 |
Wright CM, Heins RA, Ostermeier M. As easy as flipping a switch? Current Opinion in Chemical Biology. 11: 342-6. PMID 17466569 DOI: 10.1016/J.Cbpa.2007.04.011 |
0.808 |
|
| 2007 |
Liang J, Kim JR, Boock JT, Mansell TJ, Ostermeier M. Ligand binding and allostery can emerge simultaneously. Protein Science : a Publication of the Protein Society. 16: 929-37. PMID 17400921 DOI: 10.1110/Ps.062706007 |
0.537 |
|
| 2006 |
Durai S, Bosley A, Abulencia AB, Chandrasegaran S, Ostermeier M. A bacterial one-hybrid selection system for interrogating zinc finger-DNA interactions. Combinatorial Chemistry & High Throughput Screening. 9: 301-11. PMID 16724921 DOI: 10.2174/138620706776843147 |
0.806 |
|
| 2006 |
Kim JR, Ostermeier M. Modulation of effector affinity by hinge region mutations also modulates switching activity in an engineered allosteric TEM1 beta-lactamase switch. Archives of Biochemistry and Biophysics. 446: 44-51. PMID 16384549 DOI: 10.1016/J.Abb.2005.11.014 |
0.405 |
|
| 2005 |
Paschon DE, Patel ZS, Ostermeier M. Enhanced catalytic efficiency of aminoglycoside phosphotransferase (3')-IIa achieved through protein fragmentation and reassembly. Journal of Molecular Biology. 353: 26-37. PMID 16168439 DOI: 10.1016/J.Jmb.2005.08.026 |
0.755 |
|
| 2005 |
Guntas G, Mansell TJ, Kim JR, Ostermeier M. Directed evolution of protein switches and their application to the creation of ligand-binding proteins. Proceedings of the National Academy of Sciences of the United States of America. 102: 11224-9. PMID 16061816 DOI: 10.1073/Pnas.0502673102 |
0.818 |
|
| 2005 |
Ostermeier M. Engineering allosteric protein switches by domain insertion. Protein Engineering, Design & Selection : Peds. 18: 359-64. PMID 16043448 DOI: 10.1093/Protein/Gzi048 |
0.363 |
|
| 2005 |
Choe W, Chandrasegaran S, Ostermeier M. Protein fragment complementation in M.HhaI DNA methyltransferase. Biochemical and Biophysical Research Communications. 334: 1233-40. PMID 16040000 DOI: 10.1016/J.Bbrc.2005.07.017 |
0.364 |
|
| 2005 |
Bosley AD, Ostermeier M. Mathematical expressions useful in the construction, description and evaluation of protein libraries. Biomolecular Engineering. 22: 57-61. PMID 15857784 DOI: 10.1016/J.Bioeng.2004.11.002 |
0.785 |
|
| 2004 |
Guntas G, Mitchell SF, Ostermeier M. A molecular switch created by in vitro recombination of nonhomologous genes. Chemistry & Biology. 11: 1483-7. PMID 15555998 DOI: 10.1016/J.Chembiol.2004.08.020 |
0.799 |
|
| 2004 |
Paschon DE, Ostermeier M. Construction of protein fragment complementation libraries using incremental truncation. Methods in Enzymology. 388: 103-16. PMID 15289065 DOI: 10.1016/S0076-6879(04)88010-8 |
0.762 |
|
| 2004 |
Guntas G, Ostermeier M. Creation of an allosteric enzyme by domain insertion. Journal of Molecular Biology. 336: 263-73. PMID 14741221 DOI: 10.1016/J.Jmb.2003.12.016 |
0.812 |
|
| 2003 |
Lutz S, Ostermeier M. Preparation of SCRATCHY hybrid protein libraries: size- and in-frame selection of nucleic acid sequences. Methods in Molecular Biology (Clifton, N.J.). 231: 143-51. PMID 12824611 DOI: 10.1385/1-59259-395-X:143 |
0.311 |
|
| 2003 |
Ostermeier M, Lutz S. The creation of ITCHY hybrid protein libraries. Methods in Molecular Biology (Clifton, N.J.). 231: 129-41. PMID 12824610 DOI: 10.1385/1-59259-395-X:129 |
0.362 |
|
| 2003 |
Ostermeier M. Synthetic gene libraries: in search of the optimal diversity. Trends in Biotechnology. 21: 244-7. PMID 12788541 DOI: 10.1016/S0167-7799(03)00089-1 |
0.34 |
|
| 2001 |
Lutz S, Ostermeier M, Moore GL, Maranas CD, Benkovic SJ. Creating multiple-crossover DNA libraries independent of sequence identity. Proceedings of the National Academy of Sciences of the United States of America. 98: 11248-53. PMID 11562494 DOI: 10.1073/Pnas.201413698 |
0.383 |
|
| 2001 |
Lutz S, Ostermeier M, Benkovic SJ. Rapid generation of incremental truncation libraries for protein engineering using alpha-phosphothioate nucleotides. Nucleic Acids Research. 29: E16. PMID 11160936 DOI: 10.1093/Nar/29.4.E16 |
0.406 |
|
| 2001 |
Ostermeier M, Benkovic SJ. Construction of hybrid gene libraries involving the circular permutation of DNA Biotechnology Letters. 23: 303-310. DOI: 10.1023/A:1005642725295 |
0.373 |
|
| 2000 |
Ostermeier M, Benkovic SJ. Evolution of protein function by domain swapping Advances in Protein Chemistry. 55: 29-78. PMID 11050932 DOI: 10.1016/S0065-3233(01)55002-0 |
0.422 |
|
| 1999 |
Ostermeier M, Shim JH, Benkovic SJ. A combinatorial approach to hybrid enzymes independent of DNA homology Nature Biotechnology. 17: 1205-1209. PMID 10585719 DOI: 10.1038/70754 |
0.364 |
|
| 1999 |
Ostermeier M, Nixon AE, Benkovic SJ. Incremental truncation as a strategy in the engineering of novel biocatalysts Bioorganic and Medicinal Chemistry. 7: 2139-2144. PMID 10579518 DOI: 10.1016/S0968-0896(99)00143-1 |
0.438 |
|
| 1999 |
Ostermeier M, Benkovic SJ. Finding Cinderella's slipper--proteins that fit. Nature Biotechnology. 17: 639-40. PMID 10409352 DOI: 10.1038/10850 |
0.355 |
|
| 1999 |
Ostermeier M, Nixon AE, Shim JH, Benkovic SJ. Combinatorial protein engineering by incremental truncation. Proceedings of the National Academy of Sciences of the United States of America. 96: 3562-7. PMID 10097076 DOI: 10.1073/Pnas.96.7.3562 |
0.405 |
|
| 1996 |
Ostermeier M, De Sutter K, Georgiou G. Eukaryotic protein disulfide isomerase complements Escherichia coli dsbA mutants and increases the yield of a heterologous secreted protein with disulfide bonds. The Journal of Biological Chemistry. 271: 10616-22. PMID 8631865 DOI: 10.1074/Jbc.271.18.10616 |
0.537 |
|
| 1994 |
Georgiou G, Valax P, Ostermeier M, Horowitz PM. Folding and aggregation of TEM beta-lactamase: analogies with the formation of inclusion bodies in Escherichia coli. Protein Science : a Publication of the Protein Society. 3: 1953-60. PMID 7703842 DOI: 10.1002/Pro.5560031107 |
0.475 |
|
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