Steven L. Highfill, Ph.D. - Publications

Affiliations: 
2010 Microbiology, Immunology and Cancer Biology University of Minnesota, Twin Cities, Minneapolis, MN 
Area:
Immunology

76 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Song HW, Benzaoui M, Dwivedi A, Underwood S, Shao L, Achar S, Posarac V, Remley VA, Prochazkova M, Cai Y, Jin P, Somerville RP, Stroncek DF, Altan-Bonnet G, Shah NN, ... ... Highfill SL, et al. Manufacture of CD22 CAR T cells following positive versus negative selection results in distinct cytokine secretion profiles and γδ T cell output. Molecular Therapy. Methods & Clinical Development. 32: 101171. PMID 38298420 DOI: 10.1016/j.omtm.2023.101171  0.44
2023 Mikkilineni L, Natrakul DA, Lam N, Manasanch EE, Mann J, Weissler KA, Wong N, Brudno JN, Goff SL, Yang JC, Ganaden M, Patel R, Zheng Z, Gartner JJ, Martin KR, ... ... Highfill SL, et al. Rapid anti-myeloma activity by T cells expressing an anti-BCMA CAR with a human heavy-chain-only antigen-binding domain. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 38155568 DOI: 10.1016/j.ymthe.2023.12.018  0.407
2023 Kaczanowska S, Murty T, Alimadadi A, Contreras CF, Duault C, Subrahmanyam PB, Reynolds W, Gutierrez NA, Baskar R, Wu CJ, Michor F, Altreuter J, Liu Y, Jhaveri A, Duong V, ... ... Highfill SL, et al. Immune determinants of CAR-T cell expansion in solid tumor patients receiving GD2 CAR-T cell therapy. Cancer Cell. PMID 38134936 DOI: 10.1016/j.ccell.2023.11.011  0.431
2023 Cai Y, Prochazkova M, Kim YS, Jiang C, Ma J, Moses L, Martin K, Pham V, Zhang N, Highfill SL, Somerville RP, Stroncek DF, Jin P. Assessment and comparison of viability assays for cellular products. Cytotherapy. PMID 38085197 DOI: 10.1016/j.jcyt.2023.11.008  0.348
2023 Brudno JN, Natrakul DA, Karrs JX, Patel N, Maass-Moreno R, Ahlman MA, Mikkilineni L, Mann J, Stroncek DF, Highfill SL, Fromm GC, Patel R, Pittaluga S, Kochenderfer JN. Transient responses and significant toxicities of anti-CD30 CAR T cells for CD30+ lymphomas: results of a phase I trial. Blood Advances. PMID 37939262 DOI: 10.1182/bloodadvances.2023011470  0.347
2023 Tian M, Wei JS, Shivaprasad N, Highfill SL, Gryder BE, Milewski D, Brown GT, Moses L, Song H, Wu JT, Azorsa P, Kumar J, Schneider D, Chou HC, Song YK, et al. Preclinical development of a chimeric antigen receptor T cell therapy targeting FGFR4 in rhabdomyosarcoma. Cell Reports. Medicine. 101212. PMID 37774704 DOI: 10.1016/j.xcrm.2023.101212  0.401
2023 Ma J, Shao L, Fuksenko T, Liu H, Shi R, Dinh A, Highfill SL, Zhang N, Panch SR, Somerville RP, Stroncek DF, Jin P. Reference gene selection for clinical chimeric antigen receptor T-cell product vector copy number assays. Cytotherapy. PMID 36935289 DOI: 10.1016/j.jcyt.2023.02.010  0.316
2022 Dreyzin A, Panch SR, Shalabi H, Yates B, Highfill SL, Jin P, Stroncek D, Shah NN. Cryopreserved anti-CD22 and bispecific anti-CD19/22 CAR T cells are as effective as freshly infused cells. Molecular Therapy. Methods & Clinical Development. 28: 51-61. PMID 36620075 DOI: 10.1016/j.omtm.2022.12.004  0.522
2022 Shao L, Shi R, Zhao Y, Liu H, Lu A, Ma J, Cai Y, Fuksenko T, Pelayo A, Shah NN, Kochenderfer JN, Norberg SM, Hinrichs C, Highfill SL, Somerville RP, et al. Genome-wide profiling of retroviral DNA integration and its effect on clinical pre-infusion CAR T-cell products. Journal of Translational Medicine. 20: 514. PMID 36348415 DOI: 10.1186/s12967-022-03729-5  0.352
2022 Smith RH, Bloomer H, Fink D, Keyvanfar K, Nasimuzzaman M, Sancheznieto F, Dutta R, Guenther Bui K, Alvarado LJ, Bauer TR, Hickstein D, Russell D, Malik P, Van Der Loo J, Highfill SL, et al. Preclinical Evaluation of Foamy Virus Vector-Mediated Gene Addition in Human Hematopoietic Stem/Progenitor Cells for Correction of LAD-1. Human Gene Therapy. PMID 36094106 DOI: 10.1089/hum.2022.065  0.309
2022 Shalabi H, Qin H, Su A, Yates B, Wolters PL, Steinberg SM, Ligon JA, Silbert S, DéDé K, Benzaoui M, Goldberg SY, Achar S, Schneider D, Shahani SA, Little L, ... ... Highfill SL, et al. CD19/22 CAR T-cells in Children and Young Adults with B-ALL: Phase I Results and Development of a Novel Bicistronic CAR. Blood. PMID 35605184 DOI: 10.1182/blood.2022015795  0.38
2022 Holland EM, Molina JC, Dede K, Moyer D, Zhou T, Yuan CM, Wang HW, Stetler-Stevenson M, Mackall C, Fry TJ, Panch S, Highfill S, Stroncek D, Little L, Lee DW, et al. Efficacy of second CAR-T (CART2) infusion limited by poor CART expansion and antigen modulation. Journal For Immunotherapy of Cancer. 10. PMID 35534047 DOI: 10.1136/jitc-2021-004483  0.393
2022 Song HW, Somerville RP, Stroncek DF, Highfill SL. Scaling up and scaling out: Advances and challenges in manufacturing engineered T cell therapies. International Reviews of Immunology. 1-11. PMID 35486592 DOI: 10.1080/08830185.2022.2067154  0.479
2021 Cai Y, Prochazkova M, Jiang C, Song HW, Jin J, Moses L, Gkitsas N, Somerville RP, Highfill SL, Panch S, Stroncek DF, Jin P. Establishment and validation of in-house cryopreserved CAR/TCR-T cell flow cytometry quality control. Journal of Translational Medicine. 19: 523. PMID 34952597 DOI: 10.1186/s12967-021-03193-7  0.346
2021 Lichtenstein DA, Schischlik F, Shao L, Steinberg SM, Yates B, Wang HW, Wang Y, Inglefield J, Dulau Florea A, Ceppi F, Hermida LC, Stringaris K, Dunham K, Homan PJ, Jailwala P, ... ... Highfill SL, et al. Characterization of HLH-Like Manifestations as a CRS Variant in Patients Receiving CD22 CAR T-Cells. Blood. PMID 34525183 DOI: 10.1182/blood.2021011898  0.486
2021 Singh N, Frey NV, Engels B, Barrett DM, Shestova O, Ravikumar P, Cummins KD, Lee YG, Pajarillo R, Chun I, Shyu A, Highfill SL, Price A, Zhao L, Peng L, et al. Antigen-independent activation enhances the efficacy of 4-1BB-costimulated CD22 CAR T cells. Nature Medicine. PMID 33888899 DOI: 10.1038/s41591-021-01326-5  0.416
2021 Purwar R, Dwivedi A, Karulkar A, Ghosh S, Srinivasan S, Kumbhar BV, Jaiswal AK, Kizhakeyil A, Asija S, Rafiq A, Kumar S, Nisar A, Patil DP, Poojary MV, Jain H, ... ... Highfill SL, et al. Robust anti-tumor activity and low cytokine production by novel humanized anti-CD19 CAR-T cells. Molecular Cancer Therapeutics. PMID 33632869 DOI: 10.1158/1535-7163.MCT-20-0476  0.512
2021 Nagarsheth NB, Norberg SM, Sinkoe AL, Adhikary S, Meyer TJ, Lack JB, Warner AC, Schweitzer C, Doran SL, Korrapati S, Stevanović S, Trimble CL, Kanakry JA, Bagheri MH, Ferraro E, ... ... Highfill S, et al. TCR-engineered T cells targeting E7 for patients with metastatic HPV-associated epithelial cancers. Nature Medicine. PMID 33558725 DOI: 10.1038/s41591-020-01225-1  0.36
2020 Keskar V, Sood A, Loghin E, Kovacs E, Duthie RS, Liu S, Park JH, Chadwick C, Smith R, Brown M, Stroncek DF, Highfill SL. Novel DNA-based T-Cell Activator Promotes Rapid T-Cell Activation and Expansion. Journal of Immunotherapy (Hagerstown, Md. : 1997). PMID 32796275 DOI: 10.1097/Cji.0000000000000329  0.519
2020 Lu A, Liu H, Shi R, Cai Y, Ma J, Shao L, Rong V, Gkitsas N, Lei H, Highfill SL, Panch S, Stroncek DF, Jin P. Application of droplet digital PCR for the detection of vector copy number in clinical CAR/TCR T cell products. Journal of Translational Medicine. 18: 191. PMID 32384903 DOI: 10.1186/S12967-020-02358-0  0.502
2020 Shah NN, Highfill SL, Shalabi H, Yates B, Jin J, Wolters PL, Ombrello A, Steinberg SM, Martin S, Delbrook C, Hoffman L, Little L, Ponduri A, Qin H, Qureshi H, et al. CD4/CD8 T-Cell Selection Affects Chimeric Antigen Receptor (CAR) T-Cell Potency and Toxicity: Updated Results From a Phase I Anti-CD22 CAR T-Cell Trial. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. JCO1903279. PMID 32286905 DOI: 10.1200/Jco.19.03279  0.529
2020 Nelson RC, Fellowes V, Jin P, Liu H, Highfill SL, Ren J, Szymanski J, Flegel WA, Stroncek DF. Group O plasma as a media supplement for CAR-T cells and other adoptive T-cell therapies. Transfusion. PMID 32167176 DOI: 10.1111/Trf.15745  0.495
2020 Norberg S, Nagarsheth N, Sinkoe A, Adhikary S, Meyer T, Lack J, Kanakry JA, Bagheri M, Schweitzer C, Astrow SH, Bot A, Stroncek D, Gkitsas N, Highfill S, Hinrichs CS. Safety and clinical activity of gene-engineered T-cell therapy targeting HPV-16 E7 for epithelial cancers. Journal of Clinical Oncology. 38: 101-101. DOI: 10.1200/Jco.2020.38.15_Suppl.101  0.487
2020 Clara JA, Reger R, Chakraborty M, Highfill SL, Jin J, Stroncek DF, Childs RW. Cell Density of NK Cells during Ex Vivo Expansion Impacts NK Cell Surface TRAIL Expression Blood. 136: 5-6. DOI: 10.1182/blood-2020-141487  0.353
2020 Mikkilineni L, Manasanch EE, Vanasse D, Brudno JN, Mann J, Sherry R, Goff SL, Yang JC, Lam N, Maric I, Stetler-Stevenson M, Wang H, Yuan CM, Stroncek DF, Highfill SL, et al. Deep and Durable Remissions of Relapsed Multiple Myeloma on a First-in-Humans Clinical Trial of T Cells Expressing an Anti-B-Cell Maturation Antigen (BCMA) Chimeric Antigen Receptor (CAR) with a Fully-Human Heavy-Chain-Only Antigen Recognition Domain Blood. 136: 50-51. DOI: 10.1182/BLOOD-2020-138839  0.36
2020 Shalabi H, Yates B, Shahani S, Qin H, HIghfill SL, Panch S, Tran M, Stroncek D, Hoffman L, Little L, Graap K, Stetler-Stevenson M, Yuan C, Wang H, Fry TJ, et al. Abstract CT051: Safety and efficacy of CD19/CD22 CAR T cells in children and young adults with relapsed/refractory ALL Tumor Biology. DOI: 10.1158/1538-7445.Am2020-Ct051  0.422
2020 Lichtenstein DA, Steinberg SM, Highfill SL, Yates B, Jin P, Jin J, Panch S, Shalabi H, Stroncek DF, Fry TJ, Shah NN. Abstract 4231: Factors predictive of CAR T cell associated hemophagocytic lymphohistiocytosis (HLH) Cancer Research. 80: 4231-4231. DOI: 10.1158/1538-7445.Am2020-4231  0.573
2020 Fellowes V, Cai Y, Rodriguez-Mesa E, Grandinetti P, Jin J, Highfill SL, Schneider D, Dropulic B, Stroncek D, Gress R, Gattinoni L. Development of a closed system process for purifying naive CD8+ cells, culturing and transducing with a CD19/22 chimeric antigen receptor (CAR) to produce a clinical T memory stem cell product directed against B cell malignancies Cytotherapy. 22. DOI: 10.1016/J.Jcyt.2020.03.288  0.513
2019 Panch SR, Reddy OL, Li K, Bikkani T, Rao A, Yarlagadda S, Highfill S, Fowler D, Childs RW, Battiwalla M, Barrett J, Larochelle A, Mackall C, Shah N, Stroncek DF. Robust Selections of Various Hematopoietic Cell Fractions on the CliniMACS Plus Instrument. Clinical Hematology International. 1: 161-167. PMID 34595426 DOI: 10.2991/chi.d.190529.001  0.358
2019 Stroncek DF, Reddy O, Highfill S, Panch SR. Advances in T-cell Immunotherapies. Hematology/Oncology Clinics of North America. 33: 825-837. PMID 31466607 DOI: 10.1016/J.Hoc.2019.05.006  0.536
2019 Highfill SL, Stroncek DF. Overcoming Challenges in Process Development of Cellular Therapies. Current Hematologic Malignancy Reports. PMID 31278568 DOI: 10.1007/S11899-019-00529-5  0.383
2019 Panch SR, Srivastava SK, Elavia N, McManus A, Liu S, Jin P, Highfill SL, Li X, Dagur P, Kochenderfer J, Fry TJ, Mackall CL, Lee D, Shah NN, Stroncek DF. Effect of Cryopreservation on Autologous Chimeric Antigen Receptor T Cell Characteristics. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 31178392 DOI: 10.1016/J.Ymthe.2019.05.015  0.511
2019 Ramakrishna S, Highfill SL, Walsh Z, Nguyen SM, Lei H, Shern JF, Qin H, Kraft IL, Stetler-Stevenson M, Yuan CM, Hwang JD, Feng Y, Zhu Z, Dimitrov D, Shah NN, et al. Modulation of Target Antigen Density Improves CAR T Cell Functionality and Persistence. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 31110075 DOI: 10.1158/1078-0432.Ccr-18-3784  0.485
2019 Elavia N, Panch SR, McManus A, Bikkani T, Szymanski J, Highfill SL, Jin P, Brudno J, Kochenderfer J, Stroncek DF. Effects of starting cellular material composition on chimeric antigen receptor T-cell expansion and characteristics. Transfusion. PMID 30973976 DOI: 10.1111/Trf.15287  0.534
2019 Green DS, Nunes AT, Tosh KW, David-Ocampo V, Fellowes VS, Ren J, Jin J, Frodigh SE, Pham C, Procter J, Tran C, Ekwede I, Khuu H, Stroncek DF, Highfill SL, et al. Production of a cellular product consisting of monocytes stimulated with Sylatron (Peginterferon alfa-2b) and Actimmune (Interferon gamma-1b) for human use. Journal of Translational Medicine. 17: 82. PMID 30871636 DOI: 10.1186/S12967-019-1822-6  0.403
2019 Liu S, Stroncek DF, Zhao Y, Chen V, Shi R, Chen J, Ren J, Liu H, Bae HJ, Highfill SL, Jin P. Single cell sequencing reveals gene expression signatures associated with bone marrow stromal cell subpopulations and time in culture. Journal of Translational Medicine. 17: 23. PMID 30635013 DOI: 10.1186/S12967-018-1766-2  0.366
2019 Duemler A, Green DS, Highfill SL, Stroncek D, Zoon K, Annunziata CM. Production of autologous monocytes stimulated ex vivo with peg-interferon alfa 2b and interferon gamma 1b for intraperitoneal administration in phase I clinical trial. Journal of Clinical Oncology. 37: 5-5. DOI: 10.1200/Jco.2019.37.8_Suppl.5  0.396
2019 Singh N, Frey NV, Engels B, Barrett DM, Shestova O, Ravikumar P, Shyu A, Highfill S, Zhao L, Peng L, Granda B, Ramones M, Lu XM, Christian DA, Perazzelli J, et al. Single Chain Variable Fragment Linker Length Regulates CAR Biology and T Cell Efficacy Blood. 134: 247-247. DOI: 10.1182/Blood-2019-131024  0.512
2019 Jin J, Reger R, Panch S, Childs R, Stroncek D, Highfill SL. Human natural killer cell manufacturing using a closed system process for patients with metastatic solid tumors or hematologic malignancies Cytotherapy. 21. DOI: 10.1016/J.Jcyt.2019.03.369  0.427
2018 Green DS, Nunes AT, David-Ocampo V, Ekwede IB, Houston ND, Highfill SL, Khuu H, Stroncek DF, Steinberg SM, Zoon KC, Annunziata CM. A Phase 1 trial of autologous monocytes stimulated ex vivo with Sylatron (Peginterferon alfa-2b) and Actimmune (Interferon gamma-1b) for intra-peritoneal administration in recurrent ovarian cancer. Journal of Translational Medicine. 16: 196. PMID 30012146 DOI: 10.1186/S12967-018-1569-5  0.328
2018 Jin P, Chen W, Ren J, Chen S, Wood L, Zhao Y, Remaley A, Pham C, Lian S, Liu S, Liu H, Highfill S, Berzofsky JA, Stroncek DF. Plasma from some cancer patients inhibits adenoviral Ad5f35 vector transduction of dendritic cells. Cytotherapy. PMID 29655599 DOI: 10.1016/J.Jcyt.2018.03.001  0.355
2018 Jin J, Gkitsas N, Fellowes VS, Ren J, Feldman SA, Hinrichs CS, Stroncek DF, Highfill SL. Enhanced clinical-scale manufacturing of TCR transduced T-cells using closed culture system modules. Journal of Translational Medicine. 16: 13. PMID 29368612 DOI: 10.1186/S12967-018-1384-Z  0.514
2018 Nagarsheth N, Norberg S, Doran SL, Kanakry JA, Adhikary S, Schweitzer C, Astrow SH, Faquin WC, Gkitsas N, Highfill S, Stroncek D, Hinrichs C. Regression of epithelial cancers in humans following t-cell receptor gene therapy targeting human papillomavirus-16 E7. Journal of Clinical Oncology. 36: 3043-3043. DOI: 10.1200/Jco.2018.36.15_Suppl.3043  0.446
2018 Cortese I, Barrett AJ, Stroncek DF, Highfill S, Beck E, Andrada F, Ohayon J, Dwyer J, Schindler M, Aue G, Reich D, Nath A, Muranski P. A Pilot Study of Adoptive Cellular Immunotherapy for Progressive Multifocal Leukoencephalopathy with Ex Vivo Generated Polyomavirus-Specific T-Cells Blood. 132: 4535-4535. DOI: 10.1182/Blood-2018-99-119832  0.419
2018 Muranski P, Davies SI, Ito S, Koklanaris E, Superata J, Yu Q, Highfill SL, Sabatino M, Stroncek DF, Battiwalla M, Barrett AJ. Very Early Adoptive Transfer of Ex Vivo Generated Multi-Virus Specific T Cells Is a Safe Strategy for Prevention of Viral Infection after Allogeneic T Cell Depleted Stem Cell Transplantation Blood. 132: 812-812. DOI: 10.1182/Blood-2018-99-119314  0.513
2018 Norberg SM, Nagarsheth N, Doran S, Kanakry JA, Adhikary S, Schweitzer C, Astrow SH, Faquin W, Gkitsas N, Highfill S, Hinrichs CS. Regression of Epithelial Cancers Following T Cell Receptor Gene Therapy Targeting Human Papillomavirus-16 E7 Blood. 132: 492-492. DOI: 10.1182/Blood-2018-99-117017  0.451
2018 Srivastava SK, Panch SR, Jin J, Shalabi H, Shah NN, Highfill SL, Stroncek DF. Abbreviated T-Cell Activation on the Automated Clinimacs Prodigy Device Enhances Bispecific CD19/22 Chimeric Antigen Receptor T-Cell Viability and Fold Expansion, Reducing Total Culture Duration Blood. 132: 4551-4551. DOI: 10.1182/Blood-2018-99-116846  0.548
2018 Nadal R, Cherkasova E, Barisic S, Granadier D, Aue G, Wells B, Hawks G, Hughes T, Shalabi R, Stroncek D, Highfill S, Scurti G, Chen L, Reger R, Nishimura M, et al. A phase I study of HERV-E TCR transduced autologous T Cells (HERV-E TCR T Cells) in patients (pts) with metastatic clear cell renal cell carcinoma (mccRCC). Annals of Oncology. 29. DOI: 10.1093/Annonc/Mdy283.133  0.481
2017 Stroncek DF, Lee DW, Ren J, Sabatino M, Highfill S, Khuu H, Shah NN, Kaplan RN, Fry TJ, Mackall CL. Elutriated lymphocytes for manufacturing chimeric antigen receptor T cells. Journal of Translational Medicine. 15: 59. PMID 28298232 DOI: 10.1186/S12967-017-1160-5  0.507
2017 Shah NN, Highfill SL, Shalabi H, Yates B, Kane E, Fellowes V, Delbrook C, Ren J, Jin J, Stroncek D, Fry TJ. CD4/CD8 T-Cell Selection Enhances CD22 CAR-T Cell Transduction and in-Vivo CAR-T Expansion: Updated Results on Phase I Anti-CD22 CAR Dose Expansion Cohort Blood. 130: 809-809. DOI: 10.1182/Blood.V130.Suppl_1.809.809  0.543
2017 Elavia N, McManus A, Highfill SL, Ren J, Shah NN, Fry TJ, Brudno J, Kochenderfer JN, Stroncek D, Panch SR. The Post-Thaw Recovery of Cryopreserved Chimeric Antigen Receptor (CAR) T-Cells during Manufacture Is Better Than That of Cryopreserved Peripheral Blood CD3+ Cells Blood. 130: 4475-4475. DOI: 10.1182/Blood.V130.Suppl_1.4475.4475  0.51
2017 Ramakrishna S, Nguyen SM, Qin H, Highfill SL, Kraft I, Shern J, Walsh Z, Dimitrov D, Fry TJ. Modulation of CD22 Antigen Density Improves Efficacy of CD22 Chimeric Antigen Receptor (CAR) T Cells Against CD22lo B-Lineage Leukemia and Lymphoma Blood. 130: 3894-3894. DOI: 10.1182/Blood.V130.Suppl_1.3894.3894  0.451
2017 Battiwalla M, Zhang N, Li Z, Whitehill G, Wong S, Jain P, Ito S, Muranski P, Highfill SL, Stroncek D, Barrett J. Selective depletion of alloreactive donor t cells with adenosine—clinical scale up for allogeneic stem cell transplantation Cytotherapy. 19. DOI: 10.1016/J.Jcyt.2017.02.028  0.479
2017 Highfill SL, Jin J, Fellowes V, Ren J, Ramakrishna S, Fry T, Stroncek D. CD4 and CD8 T-cell positive selection increases the robustness of the CD22 CAR T-cell manufacturing process Cytotherapy. 19. DOI: 10.1016/J.Jcyt.2017.02.022  0.5
2017 Muranski P, Whitehill G, Davies SI, Yu Q, Sabatino M, Highfill S, Khuu H, Chang M, Chawla U, Anandi P, Spyridonidis A, Ito S, Stroncek DF, Battiwalla M, Barrett AJ. Early Adoptive Transfer of Ex Vivo Generated Multi-Virus Specific T Cells is a Safe Strategy to Prevent Viral Reactivation in Recipients of Allogeneic T Cell Depleted Stem Cell Transplant Biology of Blood and Marrow Transplantation. 23. DOI: 10.1016/J.Bbmt.2016.12.349  0.525
2016 Long AH, Highfill SL, Cui Y, Smith JP, Walker AJ, Ramakrishna S, El-Etriby R, Galli S, Tsokos M, Orentas RJ, Mackall CL. Reduction of MDSCs with all-trans retinoic acid improves CAR therapy efficacy for sarcomas. Cancer Immunology Research. PMID 27549124 DOI: 10.1158/2326-6066.Cir-15-0230  0.562
2016 Muranski P, Whitehill G, Draper D, Koklanaris E, Superata J, Yu Q, Sabatino M, Highfill SL, Khuu H, Davies SI, Chang M, Chawla U, Spyridonidis A, Fahle G, Ito S, et al. Early Adoptive Transfer of Ex Vivo Generated Multi-Virus Specific T Cells Is a Safe Strategy to Prevent Viral Reactivation in Recipients of Allogeneic T Cell Depleted Stem Cell Transplant Blood. 128: 979-979. DOI: 10.1182/Blood.V128.22.979.979  0.524
2015 Giles AJ, Reid CM, Evans JD, Murgai M, Vicioso Y, Highfill SL, Kasai M, Vahdat L, Mackall CL, Lyden D, Wexler L, Kaplan RN. Activation of hematopoietic stem/progenitor cells promotes immunosuppression within the pre-metastatic niche. Cancer Research. PMID 26719537 DOI: 10.1158/0008-5472.Can-15-0204  0.424
2015 Giles AJ, Murgai M, Vicioso Y, Highfill S, Kasai M, Vahdat L, Wexler L, Mackall C, Lyden D, Kaplan R. Abstract 4725: Hematopoietic stem cell niche activation and progenitor mobilization mediate cancer-associated immunosuppression and metastasis Cancer Research. 75: 4725-4725. DOI: 10.1158/1538-7445.Am2015-4725  0.39
2014 May SL, Zhou Q, Lewellen M, Carter CM, Coffey D, Highfill SL, Bucher CM, Matise I, Morse HC, O'Sullivan MG, Schutten M, Johnson C, Bellgrau D, Blazar BR, Modiano JF. Nfatc2 and Tob1 have non-overlapping function in T cell negative regulation and tumorigenesis. Plos One. 9: e100629. PMID 24945807 DOI: 10.1371/Journal.Pone.0100629  0.637
2014 Highfill SL, Cui Y, Giles AJ, Smith JP, Zhang H, Morse E, Kaplan RN, Mackall CL. Disruption of CXCR2-mediated MDSC tumor trafficking enhances anti-PD1 efficacy. Science Translational Medicine. 6: 237ra67. PMID 24848257 DOI: 10.1126/Scitranslmed.3007974  0.339
2013 Duncan BB, Highfill SL, Qin H, Bouchkouj N, Larabee S, Zhao P, Woznica I, Liu Y, Li Y, Wu W, Lai JH, Jones B, Mackall CL, Bachovchin WW, Fry TJ. A pan-inhibitor of DASH family enzymes induces immune-mediated regression of murine sarcoma and is a potent adjuvant to dendritic cell vaccination and adoptive T-cell therapy. Journal of Immunotherapy (Hagerstown, Md. : 1997). 36: 400-11. PMID 23994886 DOI: 10.1097/Cji.0B013E3182A80213  0.388
2013 Lundström W, Highfill S, Walsh ST, Beq S, Morse E, Kockum I, Alfredsson L, Olsson T, Hillert J, Mackall CL. Soluble IL7Rα potentiates IL-7 bioactivity and promotes autoimmunity. Proceedings of the National Academy of Sciences of the United States of America. 110: E1761-70. PMID 23610432 DOI: 10.1073/Pnas.1222303110  0.336
2013 Highfill SL, Long AH, Orentas RJ, Mackall CL. Neutralization of murine myeloid-derived suppressor cells enhances the efficacy of a chimeric antigen receptor T-cells directed against pediatric solid tumors Journal For Immunotherapy of Cancer. 1: 265. DOI: 10.1186/2051-1426-1-S1-P265  0.516
2013 Giles A, Vicioso Y, Kasai M, Highfill S, Mendoza A, Kaplan R. Bone marrow-derived progenitor cells develop into myeloid-derived suppressor cells at metastatic sites Journal For Immunotherapy of Cancer. 1: 188. DOI: 10.1186/2051-1426-1-S1-P188  0.447
2013 Giles A, Vicioso Y, Persenaire C, Kasai M, Highfill S, Mendoza A, Kaplan R. Abstract LB-284: Bone marrow-derived progenitor cells develop into myeloid-derived suppressor cells at metastatic sites. Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Lb-284  0.419
2013 Long AH, Highfill SL, Haso WM, Orentas RJ, Mackall CL. Abstract 3974: Evaluating the susceptibility of solid tumors to chimeric antigen receptor modified T cell therapies. Cancer Research. 73: 3974-3974. DOI: 10.1158/1538-7445.Am2013-3974  0.534
2010 Highfill SL, Rodriguez PC, Zhou Q, Goetz CA, Koehn BH, Veenstra R, Taylor PA, Panoskaltsis-Mortari A, Serody JS, Munn DH, Tolar J, Ochoa AC, Blazar BR. Bone marrow myeloid-derived suppressor cells (MDSCs) inhibit graft-versus-host disease (GVHD) via an arginase-1-dependent mechanism that is up-regulated by interleukin-13. Blood. 116: 5738-47. PMID 20807889 DOI: 10.1182/Blood-2010-06-287839  0.697
2010 Zhou Q, Munger ME, Highfill SL, Tolar J, Weigel BJ, Riddle M, Sharpe AH, Vallera DA, Azuma M, Levine BL, June CH, Murphy WJ, Munn DH, Blazar BR. Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia. Blood. 116: 2484-93. PMID 20570856 DOI: 10.1182/Blood-2010-03-275446  0.539
2010 Vogtenhuber C, Bucher C, Highfill SL, Koch LK, Goren E, Panoskaltsis-Mortari A, Taylor PA, Farrar MA, Blazar BR. Constitutively active Stat5b in CD4+ T cells inhibits graft-versus-host disease lethality associated with increased regulatory T-cell potency and decreased T effector cell responses. Blood. 116: 466-74. PMID 20442366 DOI: 10.1182/Blood-2009-11-252825  0.709
2009 Zhou Q, Bucher C, Munger ME, Highfill SL, Tolar J, Munn DH, Levine BL, Riddle M, June CH, Vallera DA, Weigel BJ, Blazar BR. Depletion of endogenous tumor-associated regulatory T cells improves the efficacy of adoptive cytotoxic T-cell immunotherapy in murine acute myeloid leukemia. Blood. 114: 3793-802. PMID 19724059 DOI: 10.1182/Blood-2009-03-208181  0.583
2009 Highfill SL, Kelly RM, O'Shaughnessy MJ, Zhou Q, Xia L, Panoskaltsis-Mortari A, Taylor PA, Tolar J, Blazar BR. Multipotent adult progenitor cells can suppress graft-versus-host disease via prostaglandin E2 synthesis and only if localized to sites of allopriming. Blood. 114: 693-701. PMID 19458354 DOI: 10.1182/Blood-2009-03-213850  0.751
2008 Kelly RM, Highfill SL, Panoskaltsis-Mortari A, Taylor PA, Boyd RL, Holländer GA, Blazar BR. Keratinocyte growth factor and androgen blockade work in concert to protect against conditioning regimen-induced thymic epithelial damage and enhance T-cell reconstitution after murine bone marrow transplantation. Blood. 111: 5734-44. PMID 18334670 DOI: 10.1182/Blood-2008-01-136531  0.672
2008 Kelly RM, Highfill SL, Panoskaltsis-Mortari A, Taylor PA, Boyd RL, Hollaender GA, Blazar BR. KGF and androgen blockade work in concert to protect against conditioning regimen‐induced thymic epithelial damage and enhance T‐cell reconstitution following murine BMT The Faseb Journal. 22: 536-536. DOI: 10.1096/Fasebj.22.2_Supplement.536  0.387
2004 Ghansah T, Paraiso KH, Highfill S, Desponts C, May S, McIntosh JK, Wang JW, Ninos J, Brayer J, Cheng F, Sotomayor E, Kerr WG. Expansion of myeloid suppressor cells in SHIP-deficient mice represses allogeneic T cell responses. Journal of Immunology (Baltimore, Md. : 1950). 173: 7324-30. PMID 15585856 DOI: 10.4049/Jimmunol.173.12.7324  0.548
2004 Wang JW, Gamsby JJ, Highfill SL, Mora LB, Bloom GC, Yeatman TJ, Pan TC, Ramne AL, Chodosh LA, Cress WD, Chen J, Kerr WG. Deregulated expression of LRBA facilitates cancer cell growth. Oncogene. 23: 4089-97. PMID 15064745 DOI: 10.1038/Sj.Onc.1207567  0.349
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