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Robert W. Huigens, Ph.D. - Publications

Affiliations: 
2009 North Carolina State University, Raleigh, NC 
Area:
Organic Chemistry, Microbiology Biology
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40 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Liu K, Xiao T, Yang H, Chen M, Gao Q, Brummel BR, Ding Y, Huigens RW. Design, synthesis and evaluation of halogenated phenazine antibacterial prodrugs targeting nitroreductase enzymes for activation. Rsc Medicinal Chemistry. 14: 1472-1481. PMID 37593580 DOI: 10.1039/d3md00204g  0.439
2023 Xiao T, Liu K, Gao Q, Chen M, Kim YS, Jin S, Ding Y, Huigens RW. Design, Synthesis, and Evaluation of Carbonate-Linked Halogenated Phenazine-Quinone Prodrugs with Improved Water-Solubility and Potent Antibacterial Profiles. Acs Infectious Diseases. PMID 36867688 DOI: 10.1021/acsinfecdis.2c00558  0.529
2022 Huigens RW, Brummel BR, Tenneti S, Garrison AT, Xiao T. Pyrazine and Phenazine Heterocycles: Platforms for Total Synthesis and Drug Discovery. Molecules (Basel, Switzerland). 27. PMID 35164376 DOI: 10.3390/molecules27031112  0.719
2022 Liu K, Brivio M, Xiao T, Norwood VM, Kim YS, Jin S, Papagni A, Vaghi L, Huigens RW. Modular Synthetic Routes to Fluorine-Containing Halogenated Phenazine and Acridine Agents That Induce Rapid Iron Starvation in Methicillin-Resistant Biofilms. Acs Infectious Diseases. PMID 35089005 DOI: 10.1021/acsinfecdis.1c00402  0.566
2021 Yang H, Kundra S, Chojnacki M, Liu K, Fuse MA, Abouelhassan Y, Kallifidas D, Zhang P, Huang G, Jin S, Ding Y, Luesch H, Rohde KH, Dunman PM, Lemos JA, ... Huigens RW, et al. A Modular Synthetic Route Involving -Aryl-2-nitrosoaniline Intermediates Leads to a New Series of 3-Substituted Halogenated Phenazine Antibacterial Agents. Journal of Medicinal Chemistry. PMID 33881312 DOI: 10.1021/acs.jmedchem.1c00168  0.579
2021 Fu T, Cai Z, Yue Z, Yang H, Fang B, Zhang X, Fan Z, Pan X, Yang F, Jin Y, Cheng Z, Wu W, Sun B, Huigens RW, Yang L, et al. Evolution of Resistance to Phenazine Antibiotics in and Its Role During Coinfection with . Acs Infectious Diseases. PMID 33650853 DOI: 10.1021/acsinfecdis.0c00837  0.371
2020 Huigens RW. Targeting bacterial biofilms with persister-killing agents. Future Medicinal Chemistry. PMID 33225755 DOI: 10.4155/fmc-2020-0314  0.418
2020 Paciaroni NG, Norwood VM, Ratnayake R, Luesch H, Huigens RW. Yohimbine as a Starting Point to Access Diverse Natural Product-Like Agents with Re-programmed Activities against Cancer-Relevant GPCR Targets. Bioorganic & Medicinal Chemistry. 28: 115546. PMID 32616180 DOI: 10.1016/J.Bmc.2020.115546  0.368
2020 Valentine-King MA, Cisneros K, James MO, Huigens RW, Brown MB. Efficacy data of halogenated phenazine and quinoline agents and an NH125 analogue to veterinary mycoplasmas. Bmc Veterinary Research. 16: 107. PMID 32252763 DOI: 10.1186/S12917-020-02324-4  0.473
2020 Norwood V, Brice-Tutt AC, Eans SO, Stacy HM, Shi G, Ratnayake R, Rocca JR, Abboud KA, Li C, Luesch H, McLaughlin JP, Huigens RW. Preventing Morphine-SeekingBehavior through the Re-Engineeringof Vincamine’s Biological Activity Journal of Medicinal Chemistry. DOI: 10.1021/Acs.Jmedchem.9B01924.S001  0.308
2019 Valentine-King MA, Cisneros K, James MO, Huigens RW, Brown MB. Turning the Tide against Antibiotic Resistance by Evaluating Novel, Halogenated Phenazine, Quinoline, and NH125 Compounds against spp. Clinical Isolates and Mycoplasma Type Strains. Antimicrobial Agents and Chemotherapy. PMID 30642935 DOI: 10.1128/Aac.02265-18  0.569
2019 Norwood VM, Huigens RW. Harnessing the Chemistry of the Indole Heterocycle to Drive Discoveries in Biology and Medicine. Chembiochem : a European Journal of Chemical Biology. PMID 30609199 DOI: 10.1002/Cbic.201800768  0.428
2018 Huigens RW. The Path to New Halogenated Quinolines With Enhanced Activities Against . Microbiology Insights. 11: 1178636118808532. PMID 30397386 DOI: 10.1177/1178636118808532  0.602
2018 Basak A, Abouelhassan Y, Kim YS, Norwood VM, Jin S, Huigens RW. Halogenated quinolines bearing polar functionality at the 2-position: Identification of new antibacterial agents with enhanced activity against Staphylococcus epidermidis. European Journal of Medicinal Chemistry. 155: 705-713. PMID 29936357 DOI: 10.1016/J.Ejmech.2018.06.045  0.646
2017 Basak A, Abouelhassan Y, Zuo R, Yousaf H, Ding Y, Huigens RW. Antimicrobial peptide-inspired NH125 analogues: bacterial and fungal biofilm-eradicating agents and rapid killers of MRSA persisters. Organic & Biomolecular Chemistry. PMID 28534905 DOI: 10.1039/C7Ob01028A  0.59
2017 Yang H, Abouelhassan Y, Burch GM, Kallifidas D, Huang G, Yousaf H, Jin S, Luesch H, Huigens RW. A Highly Potent Class of Halogenated Phenazine Antibacterial and Biofilm-Eradicating Agents Accessed Through a Modular Wohl-Aue Synthesis. Scientific Reports. 7: 2003. PMID 28515440 DOI: 10.1038/S41598-017-01045-3  0.637
2017 Paciaroni NG, Ratnayake R, Matthews JH, Norwood VM, Arnold AC, Dang LH, Luesch H, Huigens RW. Back Cover: A Tryptoline Ring‐Distortion Strategy Leads to Complex and Diverse Biologically Active Molecules from the Indole Alkaloid Yohimbine (Chem. Eur. J. 18/2017) Chemistry: a European Journal. 23: 4463-4463. DOI: 10.1002/Chem.201605731  0.332
2017 Abouelhassan Y, Basak A, Yousaf H, Huigens RW. Cover Picture: Identification of N‐Arylated NH125 Analogues as Rapid Eradicating Agents against MRSA Persister Cells and Potent Biofilm Killers of Gram‐Positive Pathogens (ChemBioChem 4/2017) Chembiochem. 18: 336-336. DOI: 10.1002/Cbic.201700034  0.571
2016 Abouelhassan Y, Yang Q, Yousaf H, Nguyen MT, Rolfe M, Schultz GS, Huigens RW. Nitroxoline: a broad-spectrum biofilm-eradicating agent against pathogenic bacteria. International Journal of Antimicrobial Agents. PMID 28110918 DOI: 10.1016/J.Ijantimicag.2016.10.017  0.639
2016 Zuo R, Garrison AT, Basak A, Zhang P, Huigens RW, Ding Y. In vitro antifungal and antibiofilm activities of halogenated quinoline analogues against Candida albicans and Cryptococcus neoformans. International Journal of Antimicrobial Agents. PMID 27256584 DOI: 10.1016/J.Ijantimicag.2016.04.019  0.788
2016 Basak A, Abouelhassan Y, Norwood VM, Bai F, Nguyen MT, Jin S, Huigens RW. Synthetically Tuning the 2-Position of Halogenated Quinolines: Optimizing Antibacterial and Biofilm Eradication Activities via Alkylation and Reductive Amination Pathways. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 27245927 DOI: 10.1002/Chem.201600926  0.668
2016 Basak A, Abouelhassan Y, Norwood VM, Bai F, Nguyen MT, Jin S, Huigens RW. Back Cover: Synthetically Tuning the 2-Position of Halogenated Quinolines: Optimizing Antibacterial and Biofilm Eradication Activities via Alkylation and Reductive Amination Pathways (Chem. Eur. J. 27/2016) Chemistry - a European Journal. 22: 9412. DOI: 10.1002/Chem.201602069  0.465
2015 Garrison AT, Abouelhassan Y, Kallifidas D, Bai F, Ukhanova M, Mai V, Jin S, Luesch H, Huigens RW. Halogenated Phenazines that Potently Eradicate Biofilms, MRSA Persister Cells in Non-Biofilm Cultures, and Mycobacterium tuberculosis. Angewandte Chemie (International Ed. in English). PMID 26480852 DOI: 10.1002/Anie.201508155  0.808
2015 Basak A, Abouelhassan Y, Huigens RW. Halogenated quinolines discovered through reductive amination with potent eradication activities against MRSA, MRSE and VRE biofilms. Organic & Biomolecular Chemistry. 13: 10290-4. PMID 26414088 DOI: 10.1039/C5Ob01883H  0.65
2015 Abouelhassan Y, Garrison AT, Bai F, Norwood VM, Nguyen MT, Jin S, Huigens RW. A Phytochemical-Halogenated Quinoline Combination Therapy Strategy for the Treatment of Pathogenic Bacteria. Chemmedchem. 10: 1157-62. PMID 25982664 DOI: 10.1002/Cmdc.201500179  0.795
2015 Garrison AT, Bai F, Abouelhassan Y, Paciaroni NG, Jin S, Huigens RW. Bromophenazine derivatives with potent inhibition, dispersion and eradication activities against Staphylococcus aureus biofilms Rsc Advances. 5: 1120-1124. DOI: 10.1039/C4Ra08728C  0.823
2014 Abouelhassan Y, Garrison AT, Burch GM, Wong W, Norwood VM, Huigens RW. Discovery of quinoline small molecules with potent dispersal activity against methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis biofilms using a scaffold hopping strategy. Bioorganic & Medicinal Chemistry Letters. 24: 5076-80. PMID 25264073 DOI: 10.1016/J.Bmcl.2014.09.009  0.823
2014 Borrero NV, Bai F, Perez C, Duong BQ, Rocca JR, Jin S, Huigens RW. Phenazine antibiotic inspired discovery of potent bromophenazine antibacterial agents against Staphylococcus aureus and Staphylococcus epidermidis. Organic & Biomolecular Chemistry. 12: 881-6. PMID 24389824 DOI: 10.1039/C3Ob42416B  0.641
2013 Huigens RW, Morrison KC, Hicklin RW, Flood TA, Richter MF, Hergenrother PJ. A ring-distortion strategy to construct stereochemically complex and structurally diverse compounds from natural products. Nature Chemistry. 5: 195-202. PMID 23422561 DOI: 10.1038/Nchem.1549  0.39
2012 Worthington RJ, Rogers SA, Huigens RW, Melander C, Ritchie DF. Foliar-Applied Small Molecule that Suppresses Biofilm Formation and Enhances Control of Copper-Resistant Xanthomonas euvesicatoria on Pepper. Plant Disease. 96: 1638-1644. PMID 30727459 DOI: 10.1094/Pdis-02-12-0190-Re  0.683
2011 Reyes S, Huigens RW, Su Z, Simon ML, Melander C. Synthesis and biological activity of 2-aminoimidazole triazoles accessed by Suzuki-Miyaura cross-coupling. Organic & Biomolecular Chemistry. 9: 3041-9. PMID 21394327 DOI: 10.1039/C0Ob00925C  0.821
2010 Reed CS, Huigens RW, Rogers SA, Melander C. Modulating the development of E. coli biofilms with 2-aminoimidazoles. Bioorganic & Medicinal Chemistry Letters. 20: 6310-2. PMID 20846860 DOI: 10.1016/J.Bmcl.2010.08.075  0.683
2010 Rogers SA, Huigens RW, Cavanagh J, Melander C. Synergistic effects between conventional antibiotics and 2-aminoimidazole-derived antibiofilm agents. Antimicrobial Agents and Chemotherapy. 54: 2112-8. PMID 20211901 DOI: 10.1128/Aac.01418-09  0.755
2010 Huigens RW, Reyes S, Reed CS, Bunders C, Rogers SA, Steinhauer AT, Melander C. The chemical synthesis and antibiotic activity of a diverse library of 2-aminobenzimidazole small molecules against MRSA and multidrug-resistant A. baumannii. Bioorganic & Medicinal Chemistry. 18: 663-74. PMID 20044260 DOI: 10.1016/J.Bmc.2009.12.003  0.785
2009 Melander C, Moeller PD, Ballard TE, Richards JJ, Huigens RW, Cavanagh J. Evaluation of dihydrooroidin as an antifouling additive in marine paint. International Biodeterioration & Biodegradation. 63: 529-532. PMID 23874076 DOI: 10.1016/J.Ibiod.2008.08.009  0.773
2009 Rogers SA, Huigens RW, Melander C. A 2-aminobenzimidazole that inhibits and disperses gram-positive biofilms through a zinc-dependent mechanism. Journal of the American Chemical Society. 131: 9868-9. PMID 19621946 DOI: 10.1021/Ja9024676  0.757
2009 Huigens RW, Rogers SA, Steinhauer AT, Melander C. Inhibition of Acinetobacter baumannii, Staphylococcus aureus and Pseudomonas aeruginosa biofilm formation with a class of TAGE-triazole conjugates. Organic & Biomolecular Chemistry. 7: 794-802. PMID 19194596 DOI: 10.1039/B817926C  0.783
2008 Huigens RW, Ma L, Gambino C, Moeller PD, Basso A, Cavanagh J, Wozniak DJ, Melander C. Control of bacterial biofilms with marine alkaloid derivatives. Molecular Biosystems. 4: 614-21. PMID 18493660 DOI: 10.1039/B719989A  0.76
2008 Richards JJ, Ballard TE, Huigens RW, Melander C. Synthesis and screening of an oroidin library against Pseudomonas aeruginosa biofilms. Chembiochem : a European Journal of Chemical Biology. 9: 1267-79. PMID 18431726 DOI: 10.1002/Cbic.200700774  0.799
2007 Huigens RW, Richards JJ, Parise G, Ballard TE, Zeng W, Deora R, Melander C. Inhibition of Pseudomonas aeruginosa biofilm formation with Bromoageliferin analogues. Journal of the American Chemical Society. 129: 6966-7. PMID 17500516 DOI: 10.1021/Ja069017T  0.803
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