Laura Jacobson - Publications

Novartis pharma, Basel, Basel, Basel-Stadt, Switzerland 

34 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Clark JW, Hoyer D, Cain SW, Phillips A, Drummond SPA, Jacobson LH. Circadian disruption impairs fear extinction and memory of conditioned safety in mice. Behavioural Brain Research. 112788. PMID 32598999 DOI: 10.1016/j.bbr.2020.112788  0.44
2020 Clark JW, Brian ML, Drummond SPA, Hoyer D, Jacobson LH. Effects of orexin receptor antagonism on human sleep architecture: A systematic review. Sleep Medicine Reviews. 53: 101332. PMID 32505969 DOI: 10.1016/j.smrv.2020.101332  0.44
2019 Metha JA, Brian ML, Oberrauch S, Barnes SA, Featherby TJ, Bossaerts P, Murawski C, Hoyer D, Jacobson LH. Separating Probability and Reversal Learning in a Novel Probabilistic Reversal Learning Task for Mice. Frontiers in Behavioral Neuroscience. 13: 270. PMID 31998088 DOI: 10.3389/fnbeh.2019.00270  0.44
2019 Hoyer D, Allen A, Jacobson LH. Hypnotics with novel modes of action. British Journal of Clinical Pharmacology. PMID 31756268 DOI: 10.1111/bcp.14180  0.44
2019 Clark JW, Drummond SPA, Hoyer D, Jacobson L. Sex differences in mouse models of fear inhibition: fear extinction, safety learning, and fear - safety discrimination. British Journal of Pharmacology. PMID 30710446 DOI: 10.1111/bph.14600  0.44
2018 Jacobson LH, Vlachou S, Slattery DA, Li X, Cryan JF. The Gamma-Aminobutyric Acid B Receptor in Depression and Reward. Biological Psychiatry. 83: 963-976. PMID 29759132 DOI: 10.1016/j.biopsych.2018.02.006  1
2017 Jacobson LH, Hoyer D, Fehlmann D, Bettler B, Kaupmann K, Cryan JF. Blunted 5-HT1A receptor-mediated responses and antidepressant-like behavior in mice lacking the GABAB1a but not GABAB1b subunit isoforms. Psychopharmacology. PMID 28070618 DOI: 10.1007/s00213-016-4521-5  1
2016 Jacobson LH, Chen S, Mir S, Hoyer D. Orexin OX2 Receptor Antagonists as Sleep Aids. Current Topics in Behavioral Neurosciences. PMID 27909987 DOI: 10.1007/7854_2016_47  0.44
2016 Shimshek DR, Jacobson LH, Kolly C, Zamurovic N, Balavenkatraman KK, Morawiec L, Kreutzer R, Schelle J, Jucker M, Bertschi B, Theil D, Heier A, Bigot K, Beltz K, Machauer R, et al. Pharmacological BACE1 and BACE2 inhibition induces hair depigmentation by inhibiting PMEL17 processing in mice. Scientific Reports. 6: 21917. PMID 26912421 DOI: 10.1038/srep21917  1
2015 Behnke D, Cotesta S, Hintermann S, Fendt M, Gee CE, Jacobson LH, Laue G, Meyer A, Wagner T, Badiger S, Chaudhari V, Chebrolu M, Pandit C, Hoyer D, Betschart C. Discovery of 1H-pyrazolo[3,4-b]pyridines as potent dual orexin receptor antagonists (DORAs). Bioorganic & Medicinal Chemistry Letters. PMID 26522950 DOI: 10.1016/j.bmcl.2015.10.055  1
2015 Jacobson LH, Sweeney FF, Kaupmann K, O'Leary OF, Gassmann M, Bettler B, Cryan JF. Differential Roles of GABAB1 Subunit Isoforms on Locomotor Responses to Acute and Repeated Administration of Cocaine. Behavioural Brain Research. PMID 26518330 DOI: 10.1016/j.bbr.2015.10.039  1
2014 Jacobson LH, Callander GE, Hoyer D. Suvorexant for the treatment of insomnia. Expert Review of Clinical Pharmacology. 7: 711-30. PMID 25318834 DOI: 10.1586/17512433.2014.966813  1
2013 Callander GE, Olorunda M, Monna D, Schuepbach E, Langenegger D, Betschart C, Hintermann S, Behnke D, Cotesta S, Fendt M, Laue G, Ofner S, Briard E, Gee CE, Jacobson LH, et al. Kinetic properties of "dual" orexin receptor antagonists at OX1R and OX2R orexin receptors. Frontiers in Neuroscience. 7: 230. PMID 24376396 DOI: 10.3389/fnins.2013.00230  1
2013 Hoyer D, Dürst T, Fendt M, Jacobson LH, Betschart C, Hintermann S, Behnke D, Cotesta S, Laue G, Ofner S, Legangneux E, Gee CE. Distinct effects of IPSU and suvorexant on mouse sleep architecture. Frontiers in Neuroscience. 7: 235. PMID 24368893 DOI: 10.3389/fnins.2013.00235  1
2013 Hoyer D, Jacobson LH. Orexin in sleep, addiction and more: is the perfect insomnia drug at hand? Neuropeptides. 47: 477-88. PMID 24215799 DOI: 10.1016/j.npep.2013.10.009  1
2013 Rueeger H, Lueoend R, Machauer R, Veenstra SJ, Jacobson LH, Staufenbiel M, Desrayaud S, Rondeau JM, Möbitz H, Neumann U. Discovery of cyclic sulfoxide hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure based design and in vivo reduction of amyloid β-peptides. Bioorganic & Medicinal Chemistry Letters. 23: 5300-6. PMID 23981898 DOI: 10.1016/j.bmcl.2013.07.071  1
2013 Betschart C, Hintermann S, Behnke D, Cotesta S, Fendt M, Gee CE, Jacobson LH, Laue G, Ofner S, Chaudhari V, Badiger S, Pandit C, Wagner J, Hoyer D. Identification of a novel series of orexin receptor antagonists with a distinct effect on sleep architecture for the treatment of insomnia. Journal of Medicinal Chemistry. 56: 7590-607. PMID 23964859 DOI: 10.1021/jm4007627  1
2013 Walker JR, Pacoma R, Watson J, Ou W, Alves J, Mason DE, Peters EC, Urbina HD, Welzel G, Althage A, Liu B, Tuntland T, Jacobson LH, Harris JL, Schumacher AM. Enhanced proteolytic clearance of plasma Aβ by peripherally administered neprilysin does not result in reduced levels of brain Aβ in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 2457-64. PMID 23392674 DOI: 10.1523/JNEUROSCI.3407-12.2013  1
2012 Rueeger H, Lueoend R, Rogel O, Rondeau JM, Möbitz H, Machauer R, Jacobson L, Staufenbiel M, Desrayaud S, Neumann U. Discovery of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure-based design and in vivo reduction of amyloid β-peptides. Journal of Medicinal Chemistry. 55: 3364-86. PMID 22380629 DOI: 10.1021/jm300069y  1
2012 Mattsson N, Rajendran L, Zetterberg H, Gustavsson M, Andreasson U, Olsson M, Brinkmalm G, Lundkvist J, Jacobson LH, Perrot L, Neumann U, Borghys H, Mercken M, Dhuyvetter D, Jeppsson F, et al. BACE1 inhibition induces a specific cerebrospinal fluid β-amyloid pattern that identifies drug effects in the central nervous system. Plos One. 7: e31084. PMID 22328928 DOI: 10.1371/journal.pone.0031084  1
2011 Jacobson LH, Commerford SR, Gerber SP, Chen YA, Dardik B, Chaperon F, Schwartzkopf C, Nguyen-Tran V, Hollenbeck T, McNamara P, He X, Liu H, Seidel HM, Jaton AL, Gromada J, et al. Characterization of a novel, brain-penetrating CB1 receptor inverse agonist: metabolic profile in diet-induced obese models and aspects of central activity. Naunyn-Schmiedeberg's Archives of Pharmacology. 384: 565-81. PMID 21947251 DOI: 10.1007/s00210-011-0686-y  1
2011 Wiessner C, Wiederhold KH, Tissot AC, Frey P, Danner S, Jacobson LH, Jennings GT, Lüönd R, Ortmann R, Reichwald J, Zurini M, Mir A, Bachmann MF, Staufenbiel M. The second-generation active Aβ immunotherapy CAD106 reduces amyloid accumulation in APP transgenic mice while minimizing potential side effects. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 9323-31. PMID 21697382 DOI: 10.1523/JNEUROSCI.0293-11.2011  1
2010 Jacobson LH, Cryan JF. Genetic approaches to modeling anxiety in animals. Current Topics in Behavioral Neurosciences. 2: 161-201. PMID 21309110 DOI: 10.1007/7854_2009_31  1
2010 Klein S, Nicolas LB, Lopez-Lopez C, Jacobson LH, McArthur SG, Grundschober C, Prinssen EP. Examining face and construct validity of a noninvasive model of panic disorder in Lister-hooded rats. Psychopharmacology. 211: 197-208. PMID 20514481 DOI: 10.1007/s00213-010-1882-z  1
2009 Eisele YS, Bolmont T, Heikenwalder M, Langer F, Jacobson LH, Yan ZX, Roth K, Aguzzi A, Staufenbiel M, Walker LC, Jucker M. Induction of cerebral beta-amyloidosis: intracerebral versus systemic Abeta inoculation. Proceedings of the National Academy of Sciences of the United States of America. 106: 12926-31. PMID 19622727 DOI: 10.1073/pnas.0903200106  1
2008 Jacobson L, Zhang R, Elliffe D, Chen KF, Mathai S, McCarthy D, Waldvogel H, Guan J. Correlation of cellular changes and spatial memory during aging in rats. Experimental Gerontology. 43: 929-38. PMID 18761081 DOI: 10.1016/j.exger.2008.08.002  1
2008 Jacobson LH, Cryan JF. Evaluation of the anxiolytic-like profile of the GABAB receptor positive modulator CGP7930 in rodents. Neuropharmacology. 54: 854-62. PMID 18328507 DOI: 10.1016/j.neuropharm.2008.01.004  1
2007 Jacobson LH, Kelly PH, Bettler B, Kaupmann K, Cryan JF. Specific roles of GABA(B(1)) receptor isoforms in cognition. Behavioural Brain Research. 181: 158-62. PMID 17498817 DOI: 10.1016/j.bbr.2007.03.033  1
2007 Jacobson LH, Bettler B, Kaupmann K, Cryan JF. Behavioral evaluation of mice deficient in GABA(B(1)) receptor isoforms in tests of unconditioned anxiety. Psychopharmacology. 190: 541-53. PMID 17171558 DOI: 10.1007/s00213-006-0631-9  1
2006 Jacobson LH, Bettler B, Kaupmann K, Cryan JF. GABAB1 receptor subunit isoforms exert a differential influence on baseline but not GABAB receptor agonist-induced changes in mice. The Journal of Pharmacology and Experimental Therapeutics. 319: 1317-26. PMID 16990508 DOI: 10.1124/jpet.106.111971  1
2006 Jacobson LH, Kelly PH, Bettler B, Kaupmann K, Cryan JF. GABA(B(1)) receptor isoforms differentially mediate the acquisition and extinction of aversive taste memories. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 8800-3. PMID 16928868 DOI: 10.1523/JNEUROSCI.2076-06.2006  1
2006 Vigot R, Barbieri S, Bräuner-Osborne H, Turecek R, Shigemoto R, Zhang YP, Luján R, Jacobson LH, Biermann B, Fritschy JM, Vacher CM, Müller M, Sansig G, Guetg N, Cryan JF, et al. Differential compartmentalization and distinct functions of GABAB receptor variants. Neuron. 50: 589-601. PMID 16701209 DOI: 10.1016/j.neuron.2006.04.014  1
2005 Jacobson LH, Cryan JF. Differential sensitivity to the motor and hypothermic effects of the GABA B receptor agonist baclofen in various mouse strains. Psychopharmacology. 179: 688-99. PMID 15668819 DOI: 10.1007/s00213-004-2086-1  1
2002 Jacobson LH, Nagle TA, Gregory NG, Graham Bell R, Le Roux G, Haines JM. Effect of feeding pasture-finished cattle different conserved forages on Escherichia coli in the rumen and faeces. Meat Science. 62: 93-106. PMID 22061197 DOI: 10.1016/S0309-1740(01)00233-9  1
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