Benjamin F. Cravatt, PhD - Publications

Affiliations: 
Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Area:
Medicinal Chemistry
Website:
http://www.scripps.edu/research/faculty/cravatt

497 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Tao Y, Remillard D, Vinogradova EV, Yokoyama M, Banchenko S, Schwefel D, Melillo B, Schreiber SL, Zhang X, Cravatt BF. Targeted Protein Degradation by Electrophilic PROTACs that Stereoselectively and Site-Specifically Engage DCAF1. Journal of the American Chemical Society. PMID 36170674 DOI: 10.1021/jacs.2c08964  0.427
2022 Feldman HC, Merlini E, Guijas C, DeMeester KE, Njomen E, Kozina EM, Yokoyama M, Vinogradova E, Reardon HT, Melillo B, Schreiber SL, Loreto A, Blankman JL, Cravatt BF. Selective inhibitors of SARM1 targeting an allosteric cysteine in the autoregulatory ARM domain. Proceedings of the National Academy of Sciences of the United States of America. 119: e2208457119. PMID 35994671 DOI: 10.1073/pnas.2208457119  0.551
2022 Morimoto K, Krahn D, Kaschani F, Hopkinson-Woolley D, Gee A, Buscaill P, Mohammed S, Sieber SA, Cravatt BF, Schofield CJ, van der Hoorn RAL. Broad-range metalloprotease profiling in plants uncovers immunity provided by defence-related metalloenzyme. The New Phytologist. PMID 35510806 DOI: 10.1111/nph.18200  0.497
2022 Xu C, Yadav-Samudrala BJ, Xu C, Nath B, Mistry T, Jiang W, Niphakis MJ, Cravatt BF, Mukhopadhyay S, Lichtman AH, Ignatowska-Jankowska BM, Fitting S. Inhibitory Neurotransmission Is Sex-Dependently Affected by Tat Expression in Transgenic Mice and Suppressed by the Fatty Acid Amide Hydrolase Enzyme Inhibitor PF3845 via Cannabinoid Type-1 Receptor Mechanisms. Cells. 11. PMID 35269478 DOI: 10.3390/cells11050857  0.523
2022 Kemper EK, Zhang Y, Dix MM, Cravatt BF. Global profiling of phosphorylation-dependent changes in cysteine reactivity. Nature Methods. PMID 35228727 DOI: 10.1038/s41592-022-01398-2  0.605
2021 Bouffard E, Zaro BW, Dix MM, Cravatt B, Wong CH. Refinement of Covalent EGFR Inhibitor AZD9291 to Eliminate Off-target Activity. Tetrahedron Letters. 74. PMID 34764521 DOI: 10.1016/j.tetlet.2021.153178  0.775
2021 Abbasov ME, Kavanagh ME, Ichu TA, Lazear MR, Tao Y, Crowley VM, Am Ende CW, Hacker SM, Ho J, Dix MM, Suciu R, Hayward MM, Kiessling LL, Cravatt BF. Publisher Correction: A proteome-wide atlas of lysine-reactive chemistry. Nature Chemistry. PMID 34588639 DOI: 10.1038/s41557-021-00823-x  0.778
2021 Abbasov ME, Kavanagh ME, Ichu TA, Lazear MR, Tao Y, Crowley VM, Am Ende CW, Hacker SM, Ho J, Dix MM, Suciu R, Hayward MM, Kiessling LL, Cravatt BF. A proteome-wide atlas of lysine-reactive chemistry. Nature Chemistry. PMID 34504315 DOI: 10.1038/s41557-021-00765-4  0.805
2021 Gao J, Liu Y, Yang F, Chen X, Cravatt BF, Wang C. CIMAGE2.0: An Expanded Tool for Quantitative Analysis of Activity-Based Protein Profiling (ABPP) Data. Journal of Proteome Research. PMID 34495668 DOI: 10.1021/acs.jproteome.1c00455  0.462
2021 League AF, Gorman BL, Hermes DJ, Johnson CT, Jacobs IR, Yadav-Samudrala BJ, Poklis JL, Niphakis MJ, Cravatt BF, Lichtman AH, Ignatowska-Jankowska BM, Fitting S. Monoacylglycerol Lipase Inhibitor MJN110 Reduces Neuronal Hyperexcitability, Restores Dendritic Arborization Complexity, and Regulates Reward-Related Behavior in Presence of HIV-1 Tat. Frontiers in Neurology. 12: 651272. PMID 34484091 DOI: 10.3389/fneur.2021.651272  0.461
2021 O'Brien LD, Smith TL, Donvito G, Cravatt BF, Newton J, Spiegel S, Reeves TM, Phillips LL, Lichtman AH. Diacylglycerol Lipase-β Knockout Mice Display a Sex-Dependent Attenuation of Traumatic Brain Injury-Induced Mortality with No Impact on Memory or Other Functional Consequences. Cannabis and Cannabinoid Research. PMID 34142866 DOI: 10.1089/can.2020.0175  0.44
2021 Garnar-Wortzel L, Bishop TR, Kitamura S, Milosevich N, Asiaban JN, Zhang X, Zheng Q, Chen E, Ramos AR, Ackerman CJ, Hampton EN, Chatterjee AK, Young TS, Hull MV, Sharpless KB, ... Cravatt BF, et al. Chemical Inhibition of ENL/AF9 YEATS Domains in Acute Leukemia. Acs Central Science. 7: 815-830. PMID 34079898 DOI: 10.1021/acscentsci.0c01550  0.38
2021 Remsberg JR, Suciu RM, Zambetti NA, Hanigan TW, Firestone AJ, Inguva A, Long A, Ngo N, Lum KM, Henry CL, Richardson SK, Predovic M, Huang B, Dix MM, Howell AR, ... ... Cravatt BF, et al. ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth. Nature Chemical Biology. PMID 33927411 DOI: 10.1038/s41589-021-00785-8  0.575
2021 Vinogradova EV, Cravatt BF. Multiplexed proteomic profiling of cysteine reactivity and ligandability in human T cells. Star Protocols. 2: 100458. PMID 33899026 DOI: 10.1016/j.xpro.2021.100458  0.524
2021 Zhang X, Luukkonen LM, Eissler CL, Crowley VM, Yamashita Y, Schafroth MA, Kikuchi S, Weinstein DS, Symons KT, Nordin BE, Rodriguez JL, Wucherpfennig TG, Bauer LG, Dix MM, Stamos D, ... ... Cravatt BF, et al. DCAF11 Supports Targeted Protein Degradation by Electrophilic Proteolysis-Targeting Chimeras. Journal of the American Chemical Society. PMID 33783207 DOI: 10.1021/jacs.1c00990  0.763
2021 Litwin K, Crowley VM, Suciu RM, Boger DL, Cravatt BF. Chemical proteomic identification of functional cysteines with atypical electrophile reactivities. Tetrahedron Letters. 67. PMID 33776155 DOI: 10.1016/j.tetlet.2021.152861  0.466
2021 Hermes DJ, Yadav-Samudrala BJ, Xu C, Paniccia JE, Meeker RB, Armstrong ML, Reisdorph N, Cravatt BF, Mackie K, Lichtman AH, Ignatowska-Jankowska BM, Lysle DT, Fitting S. GPR18 drives FAAH inhibition-induced neuroprotection against HIV-1 Tat-induced neurodegeneration. Experimental Neurology. 113699. PMID 33736974 DOI: 10.1016/j.expneurol.2021.113699  0.462
2021 Zhang X, Thielert M, Li H, Cravatt BF. SPIN4 Is a Principal Endogenous Substrate of the E3 Ubiquitin Ligase DCAF16. Biochemistry. PMID 33636084 DOI: 10.1021/acs.biochem.1c00067  0.332
2021 Kuljanin M, Mitchell DC, Schweppe DK, Gikandi AS, Nusinow DP, Bulloch NJ, Vinogradova EV, Wilson DL, Kool ET, Mancias JD, Cravatt BF, Gygi SP. Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nature Biotechnology. PMID 33398154 DOI: 10.1038/s41587-020-00778-3  0.563
2020 László ZI, Lele Z, Zöldi M, Miczán V, Mógor F, Simon GM, Mackie K, Kacskovics I, Cravatt BF, Katona I. ABHD4-dependent developmental anoikis safeguards the embryonic brain. Nature Communications. 11: 4363. PMID 32868797 DOI: 10.1038/S41467-020-18175-4  0.613
2020 Dickson P, Abegg D, Vinogradova E, Takaya J, An H, Simanski S, Cravatt BF, Adibekian A, Kodadek T. Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chemical Biology. PMID 32857985 DOI: 10.1016/J.Chembiol.2020.08.007  0.514
2020 Vaisar T, Hu JH, Airhart N, Fox KA, Heinecke JW, Nicosia RF, Kohler TR, Potter ZE, Simon GM, Dix M, Cravatt B, Gharib SA, Dichek D. Parallel Murine and Human Plaque Proteomics Reveals Pathways of Plaque Rupture. Circulation Research. PMID 32762496 DOI: 10.1161/Circresaha.120.317295  0.747
2020 Vinogradova EV, Zhang X, Remillard D, Lazar DC, Suciu RM, Wang Y, Bianco G, Yamashita Y, Crowley VM, Schafroth MA, Yokoyama M, Konrad DB, Lum KM, Simon GM, Kemper EK, ... ... Cravatt BF, et al. An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. PMID 32730809 DOI: 10.1016/J.Cell.2020.07.001  0.801
2020 Kok BP, Ghimire S, Kim W, Chatterjee S, Johns T, Kitamura S, Eberhardt J, Ogasawara D, Xu J, Sukiasyan A, Kim SM, Godio C, Bittencourt JM, Cameron M, Galmozzi A, ... ... Cravatt BF, et al. Discovery of small-molecule enzyme activators by activity-based protein profiling. Nature Chemical Biology. PMID 32514184 DOI: 10.1038/S41589-020-0555-4  0.57
2020 Muldoon PP, Akinola LS, Schlosburg JE, Lichtman AH, Sim-Selley LJ, Mahadevan A, Cravatt BF, Damaj MI. Inhibition of monoacylglycerol lipase reduces nicotine reward in the conditioned place preference test in male mice. Neuropharmacology. 108170. PMID 32479813 DOI: 10.1016/J.Neuropharm.2020.108170  0.529
2020 Mock ED, Mustafa M, Gunduz-Cinar O, Cinar R, Petrie GN, Kantae V, Di X, Ogasawara D, Varga ZV, Paloczi J, Miliano C, Donvito G, van Esbroeck ACM, van der Gracht AMF, Kotsogianni I, ... ... Cravatt BF, et al. Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice. Nature Chemical Biology. PMID 32393901 DOI: 10.1038/S41589-020-0528-7  0.584
2020 Ichu TA, Reed A, Ogasawara D, Ulanovskaya O, Roberts A, Aguirre CA, Bar-Peled L, Gao J, Germain J, Barbas S, Masuda K, Conti B, Tontonoz P, Cravatt BF. ABHD12 and LPCAT3 Interplay Regulates a Lyso-phosphatidylserine-C20:4 Phosphatidylserine Lipid Network Implicated in Neurological Disease. Biochemistry. PMID 32364701 DOI: 10.1021/Acs.Biochem.0C00292  0.303
2020 Zambaldo C, Vinogradova EV, Qi X, Iaconelli J, Suciu RM, Koh M, Senkane K, Chadwick SR, Sanchez BB, Chen JS, Chatterjee AK, Liu P, Schultz PG, Cravatt BF, Bollong MJ. 2-Sulfonyl pyridines as tunable, cysteine-reactive electrophiles. Journal of the American Chemical Society. PMID 32302104 DOI: 10.1021/Jacs.0C02721  0.608
2020 Kathman SG, Cravatt BF. A masked zinger to block GPX4. Nature Chemical Biology. 16: 482-483. PMID 32231342 DOI: 10.1038/S41589-020-0511-3  0.337
2020 Zambetti NA, Firestone AJ, Remsberg JR, Huang BJ, Wong JC, Long AM, Predovic M, Suciu RM, Inguva A, Kogan SC, Haigis KM, Cravatt BF, Shannon K. Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice. Blood. PMID 32219446 DOI: 10.1182/Blood.2019003530  0.322
2020 Kathman SG, Boshart J, Jing H, Cravatt BF. Blockade of the Lysophosphatidylserine Lipase ABHD12 Potentiates Ferroptosis in Cancer Cells. Acs Chemical Biology. PMID 32195565 DOI: 10.1021/Acschembio.0C00086  0.373
2020 Carvalho LAR, Almeida VT, Brito JA, Lum KM, Oliveira TF, C Guedes R, Gonçalves LM, Lucas SD, Cravatt BF, Archer M, Moreira R. 3-Oxo-β-Sultam as a Sulfonylating Chemotype for Inhibition of Serine Hydrolases and Activity-Based Protein Profiling. Acs Chemical Biology. PMID 32176480 DOI: 10.1021/Acschembio.0C00090  0.375
2020 Asiaban JN, Milosevich N, Chen E, Bishop TR, Wang J, Zhang Y, Ackerman CJ, Hampton E, Young TS, Hull M, Cravatt BF, Erb MA. Cell-based ligand discovery for the ENL YEATS domain. Acs Chemical Biology. PMID 32176478 DOI: 10.1021/Acschembio.0C00124  0.315
2020 Erikci Ertunc M, Kok BP, Parsons WH, Wang JG, Tan D, Donaldson CJ, Pinto AFM, Vaughan JM, Ngo N, Lum KM, Henry CL, Coppola AR, Niphakis MJ, Cravatt BF, Saez E, et al. AIG1 and ADTRP are endogenous hydrolases of fatty acid esters of hydroxy fatty acids (FAHFAs) in mice. The Journal of Biological Chemistry. PMID 32152231 DOI: 10.1074/Jbc.Ra119.012145  0.633
2020 Xu JH, Eberhardt J, Hill-Payne B, Gonzalez-Paez GE, Castellón JO, Cravatt BF, Forli S, Wolan DW, Backus KM. Integrative x-ray structure and molecular modeling for the rationalization of procaspase-8 inhibitor potency and selectivity. Acs Chemical Biology. PMID 31927936 DOI: 10.1021/Acschembio.0C00019  0.763
2020 Ertunc ME, Kok BP, Parsons WH, Wang JG, Tan D, Donaldson CJ, Pinto AM, Vaughan JM, Ngo N, Lum KM, Henry CL, Coppola AR, Niphakis MJ, Cravatt BF, Saez E, et al. Role of AIG1 and ADTRP in Endogenous FAHFA Regulation The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.04337  0.537
2019 Yamashita Y, Vinogradova E, Zhang X, Suciu R, Cravatt B. A chemical proteomic probe for the mitochondrial pyruvate carrier complex. Angewandte Chemie (International Ed. in English). PMID 31863675 DOI: 10.1002/Anie.201914391  0.643
2019 Galmozzi A, Kok BP, Kim AS, Montenegro-Burke JR, Lee JY, Spreafico R, Mosure S, Albert V, Cintron-Colon R, Godio C, Webb WR, Conti B, Solt LA, Kojetin D, Parker CG, ... ... Cravatt BF, et al. PGRMC2 is an intracellular haem chaperone critical for adipocyte function. Nature. PMID 31748741 DOI: 10.1038/S41586-019-1774-2  0.648
2019 Grevengoed TJ, Trammell SAJ, McKinney MK, Petersen N, Cardone RL, Svenningsen JS, Ogasawara D, Nexøe-Larsen CC, Knop FK, Schwartz TW, Kibbey RG, Cravatt BF, Gillum MP. -acyl taurines are endogenous lipid messengers that improve glucose homeostasis. Proceedings of the National Academy of Sciences of the United States of America. PMID 31740614 DOI: 10.1073/Pnas.1916288116  0.774
2019 Wang Y, Dix MM, Bianco G, Remsberg JR, Lee HY, Kalocsay M, Gygi SP, Forli S, Vite G, Lawrence RM, Parker CG, Cravatt BF. Expedited mapping of the ligandable proteome using fully functionalized enantiomeric probe pairs. Nature Chemistry. PMID 31659311 DOI: 10.1038/S41557-019-0351-5  0.79
2019 Jacobs IR, Xu C, Hermes DJ, League AF, Xu C, Nath B, Jiang W, Niphakis MJ, Cravatt BF, Mackie K, Mukhopadhyay S, Lichtman AH, Ignatowska-Jankowska BM, Fitting S. Inhibitory Control Deficits Associated with Upregulation of CBR in the HIV-1 Tat Transgenic Mouse Model of Hand. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. PMID 31372820 DOI: 10.1007/S11481-019-09867-W  0.513
2019 Senkane K, Vinogradova E, Suciu R, Crowley V, Zaro B, Bradshaw M, Brameld K, Cravatt B. The proteome-wide potential for reversible covalency at cysteine. Angewandte Chemie (International Ed. in English). PMID 31222866 DOI: 10.1002/Anie.201905829  0.802
2019 Zhang X, Crowley VM, Wucherpfennig TG, Dix MM, Cravatt BF. Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16. Nature Chemical Biology. 15: 737-746. PMID 31209349 DOI: 10.1038/S41589-019-0279-5  0.685
2019 Schurman LD, Carper MC, Moncayo LV, Ogasawara D, Richardson K, Yu L, Liu X, Poklis JL, Liu QS, Cravatt BF, Lichtman AH. Diacylglycerol lipase-alpha regulates hippocampal-dependent learning and memory processes in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31127001 DOI: 10.1523/Jneurosci.1353-18.2019  0.508
2019 Chen AL, Lum KM, Lara-Gonzalez P, Ogasawara D, Cognetta AB, To A, Parsons WH, Simon GM, Desai A, Petrascheck M, Bar-Peled L, Cravatt BF. Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan. Nature Chemical Biology. PMID 30911178 DOI: 10.1038/S41589-019-0243-4  0.682
2019 Zaro BW, Vinogradova EV, Lazar DC, Blewett MM, Suciu RM, Takaya J, Studer S, de la Torre JC, Casanova JL, Cravatt BF, Teijaro JR. Dimethyl Fumarate Disrupts Human Innate Immune Signaling by Targeting the IRAK4-MyD88 Complex. Journal of Immunology (Baltimore, Md. : 1950). PMID 30885957 DOI: 10.4049/Jimmunol.1801627  0.785
2019 Otrubova K, Chatterjee S, Ghimire S, Cravatt BF, Boger DL. N-Acyl pyrazoles: Effective and tunable inhibitors of serine hydrolases. Bioorganic & Medicinal Chemistry. PMID 30879861 DOI: 10.1016/J.Bmc.2019.03.020  0.537
2019 Chefetz I, Grimley E, Yang K, Hong L, Vinogradova EV, Suciu R, Kovalenko I, Karnak D, Morgan CA, Chtcherbinine M, Buchman C, Huddle B, Barraza S, Morgan M, Bernstein KA, ... ... Cravatt B, et al. A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells. Cell Reports. 26: 3061-3075.e6. PMID 30865894 DOI: 10.1016/J.Celrep.2019.02.032  0.53
2019 Ogasawara D, Ichu TA, Jing H, Hulce JJ, Reed A, Ulanovskaya OA, Cravatt BF. Discovery and Optimization of Selective and in Vivo Active Inhibitors of the Lysophosphatidylserine Lipase α/β-Hydrolase Domain-Containing 12 (ABHD12). Journal of Medicinal Chemistry. PMID 30720278 DOI: 10.1021/Acs.Jmedchem.8B01958  0.447
2019 Huang Z, Ogasawara D, Seneviratne UI, Cognetta AB, Am Ende CW, Nason DM, Lapham K, Litchfield J, Johnson DS, Cravatt BF. Global Portrait of Protein Targets of Metabolites of the Neurotoxic Compound BIA 10-2474. Acs Chemical Biology. PMID 30702848 DOI: 10.1021/Acschembio.8B01097  0.458
2018 Solis GM, Kardakaris R, Valentine ER, Bar-Peled L, Chen AL, Blewett MM, McCormick MA, Williamson JR, Kennedy B, Cravatt BF, Petrascheck M. Translation attenuation by minocycline enhances longevity and proteostasis in old post-stress-responsive organisms. Elife. 7. PMID 30479271 DOI: 10.7554/Elife.40314  0.347
2018 Ogasawara D, Ichu TA, Vartabedian VF, Benthuysen J, Jing H, Reed A, Ulanovskaya OA, Hulce JJ, Roberts A, Brown S, Rosen H, Teijaro JR, Cravatt BF. Selective blockade of the lyso-PS lipase ABHD12 stimulates immune responses in vivo. Nature Chemical Biology. PMID 30420694 DOI: 10.1038/S41589-018-0155-8  0.36
2018 Walsh SI, Peters DS, Smith PA, Craney A, Dix MM, Cravatt BF, Romesberg FE. The inhibition of protein secretion in and sub-MIC effects of arylomycin antibiotics. Antimicrobial Agents and Chemotherapy. PMID 30420476 DOI: 10.1128/Aac.01253-18  0.613
2018 Habib A, Chokr D, Wan J, Hegde P, Mabire M, Siebert M, Ribeiro-Parenti L, Le Gall M, Lettéron P, Pilard N, Mansouri A, Brouillet A, Tardelli M, Weiss E, Le Faouder P, ... ... Cravatt BF, et al. Inhibition of monoacylglycerol lipase, an anti-inflammatory and antifibrogenic strategy in the liver. Gut. PMID 30301768 DOI: 10.1136/Gutjnl-2018-316137  0.318
2018 Inloes JM, Jing H, Cravatt BF. The Spastic Paraplegia-Associated Phospholipase DDHD1 Is a Primary Brain Phosphatidylinositol Lipase. Biochemistry. PMID 30221923 DOI: 10.1021/Acs.Biochem.8B00810  0.352
2018 Aparicio N, Teresa Grande M, Ruiz de Martín Esteban S, López A, Ruiz-Pérez G, Amores M, Vázquez C, Martínez-Relimpio AM, Ruth Pazos M, Cravatt BF, Tolón RM, Romero J. Role Of Interleukin 1-Beta In The Inflammatory Response In A Fatty Acid Amide Hydrolase-Knockout Mouse Model Of Alzheimer's Disease. Biochemical Pharmacology. PMID 30195729 DOI: 10.1016/J.Bcp.2018.09.009  0.329
2018 Manterola A, Bernal-Chico A, Cipriani R, Ruiz A, Pérez-Samartín A, Moreno-Rodríguez M, Hsu KL, Cravatt B, Brown JM, Rodríguez-Puertas R, Matute C, Mato S. Re-examining the potential of targeting ABHD6 in multiple sclerosis: Efficacy of systemic and peripherally restricted inhibitors in experimental autoimmune encephalomyelitis. Neuropharmacology. PMID 30171986 DOI: 10.1016/J.Neuropharm.2018.08.038  0.687
2018 Hermes DJ, Xu C, Poklis JL, Niphakis MJ, Cravatt BF, Mackie K, Lichtman AH, Ignatowska-Jankowska BM, Fitting S. Neuroprotective effects of fatty acid amide hydrolase catabolic enzyme inhibition in a HIV-1 Tat model of neuroAIDS. Neuropharmacology. PMID 30114402 DOI: 10.1016/J.Neuropharm.2018.08.013  0.544
2018 Gavin AL, Huang D, Huber C, Mårtensson A, Tardif V, Skog PD, Blane TR, Thinnes TC, Osborn K, Chong HS, Kargaran F, Kimm P, Zeitjian A, Sielski RL, Briggs M, ... ... Cravatt B, et al. PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing. Nature Immunology. PMID 30111894 DOI: 10.1038/S41590-018-0179-Y  0.32
2018 Manterola A, Bernal-Chico A, Cipriani R, Canedo-Antelo M, Moreno-García Á, Martín-Fontecha M, Pérez-Cerdá F, Victoria Sánchez-Gómez M, Ortega-Gutiérrez S, Mark Brown J, Hsu KL, Cravatt B, Matute C, Mato S. Deregulation of the endocannabinoid system and therapeutic potential of ABHD6 blockade in the cuprizone model of demyelination. Biochemical Pharmacology. PMID 30075103 DOI: 10.1016/J.Bcp.2018.07.042  0.689
2018 Suciu RM, Cognetta AB, Potter ZE, Cravatt BF. Selective Irreversible Inhibitors of the Wnt-Deacylating Enzyme NOTUM Developed by Activity-Based Protein Profiling. Acs Medicinal Chemistry Letters. 9: 563-568. PMID 29937983 DOI: 10.1021/Acsmedchemlett.8B00191  0.444
2018 Gao DW, Vinogradova EV, Nimmagadda SK, Medina JM, Xiao Y, Suciu RM, Cravatt BF, Engle KM. Direct Access to Versatile Electrophiles via Catalytic Oxidative Cyanation of Alkenes. Journal of the American Chemical Society. PMID 29894184 DOI: 10.1021/Jacs.8B03704  0.532
2018 Galmozzi A, Parker CG, Kok BP, Cravatt BF, Saez E. Discovery of Modulators of Adipocyte Physiology Using Fully Functionalized Fragments. Methods in Molecular Biology (Clifton, N.J.). 1787: 115-127. PMID 29736714 DOI: 10.1007/978-1-4939-7847-2_9  0.653
2018 Lee HY, Suciu RM, Horning BD, Vinogradova EV, Ulanovskaya OA, Cravatt BF. Covalent inhibitors of nicotinamide N-methyltransferase (NNMT) provide evidence for target engagement challenges in situ. Bioorganic & Medicinal Chemistry Letters. PMID 29731364 DOI: 10.1016/J.Bmcl.2018.04.017  0.632
2018 Parker CG, Cravatt BF. Chemistry Takes Center Stage for Identifying Cancer Targetability. Cell. 173: 815-817. PMID 29727668 DOI: 10.1016/J.Cell.2018.04.020  0.611
2018 Dandela R, Mantin D, Cravatt BF, Rayo J, Meijler MM. Proteome-wide mapping of PQS-interacting proteins in . Chemical Science. 9: 2290-2294. PMID 29719702 DOI: 10.1039/C7Sc04287F  0.315
2018 Curry Z, Wilkerson J, Bagdas D, Kyte S, Patel N, Donvito G, Mustafa MA, Poklis J, Niphakis M, Hsu KL, Cravatt BF, Gewirtz DA, Damaj MI, Lichtman AH. Monoacylglycerol lipase inhibitors reverse paclitaxel-induced nociceptive behavior and proinflammatory markers in a mouse model of chemotherapy-induced neuropathy. The Journal of Pharmacology and Experimental Therapeutics. PMID 29540562 DOI: 10.1124/Jpet.117.245704  0.739
2018 Wilkerson JL, Curry ZA, Kinlow PD, Mason BL, Hsu KL, van der Stelt M, Cravatt BF, Lichtman AH. Evaluation of different drug classes on transient sciatic nerve injury-depressed marble burying in mice. Pain. PMID 29528965 DOI: 10.1097/J.Pain.0000000000001199  0.719
2018 Cheng R, Mori W, Ma L, Alhouayek M, Hatori A, Zhang Y, Ogasawara D, Yuan G, Chen Z, Zhang X, Shi H, Yamasaki T, Xie L, Kumata K, Fujinaga M, ... ... Cravatt BF, et al. In vitro and in vivo evaluation ofC-labeled azetidine-carboxylates for imaging monoacylglycerol lipase by PET imaging studies. Journal of Medicinal Chemistry. PMID 29481079 DOI: 10.1021/Acs.Jmedchem.7B01400  0.381
2018 Aebersold R, Agar JN, Amster IJ, Baker MS, Bertozzi CR, Boja ES, Costello CE, Cravatt BF, Fenselau C, Garcia BA, Ge Y, Gunawardena J, Hendrickson RC, Hergenrother PJ, Huber CG, et al. How many human proteoforms are there? Nature Chemical Biology. 14: 206-214. PMID 29443976 DOI: 10.1038/Nchembio.2576  0.797
2017 Parker CG, Kuttruff CA, Galmozzi A, Jørgensen L, Yeh CH, Hermanson DJ, Wang Y, Artola M, McKerrall SJ, Josyln CM, Nørremark B, Dünstl G, Felding J, Saez E, Baran PS, ... Cravatt BF, et al. Chemical Proteomics Identifies SLC25A20 as a Functional Target of the Ingenol Class of Actinic Keratosis Drugs. Acs Central Science. 3: 1276-1285. PMID 29296668 DOI: 10.1021/Acscentsci.7B00420  0.729
2017 Inloes JM, Kiosses WB, Wang H, Walther TC, Farese RV, Cravatt BF. Functional Contribution of the Spastic Paraplegia-Related Triglyceride Hydrolase DDHD2 to the Formation and Content of Lipid Droplets. Biochemistry. PMID 29278326 DOI: 10.1021/Acs.Biochem.7B01028  0.379
2017 Mortenson DE, Brighty GJ, Plate L, Bare G, Chen W, Li S, Wang H, Cravatt BF, Forli S, Powers ET, Sharpless KB, Wilson IA, Kelly JW. "Inverse Drug Discovery" Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates. Journal of the American Chemical Society. PMID 29265822 DOI: 10.1021/Jacs.7B08366  0.398
2017 Tan J, Cognetta Iii AB, Diaz DB, Lum KM, Adachi S, Kundu S, Cravatt BF, Yudin AK. Multicomponent mapping of boron chemotypes furnishes selective enzyme inhibitors. Nature Communications. 8: 1760. PMID 29170371 DOI: 10.1038/S41467-017-01319-4  0.812
2017 Hacker SM, Backus KM, Lazear MR, Forli S, Correia BE, Cravatt BF. Global profiling of lysine reactivity and ligandability in the human proteome. Nature Chemistry. 9: 1181-1190. PMID 29168484 DOI: 10.1038/Nchem.2826  0.78
2017 McReynolds JR, Doncheck EM, Li Y, Vranjkovic O, Graf EN, Ogasawara D, Cravatt BF, Baker DA, Liu QS, Hillard CJ, Mantsch JR. Stress Promotes Drug Seeking Through Glucocorticoid-Dependent Endocannabinoid Mobilization in the Prelimbic Cortex. Biological Psychiatry. PMID 29100630 DOI: 10.1016/J.Biopsych.2017.09.024  0.351
2017 Shimanaka Y, Kono N, Taketomi Y, Arita M, Okayama Y, Tanaka Y, Nishito Y, Mochizuki T, Kusuhara H, Adibekian A, Cravatt BF, Murakami M, Arai H. Omega-3 fatty acid epoxides are autocrine mediators that control the magnitude of IgE-mediated mast cell activation. Nature Medicine. PMID 29035365 DOI: 10.1038/Nm.4417  0.378
2017 Wilkerson JL, Donvito G, Grim TW, Abdullah RA, Ogasawara D, Cravatt BF, Lichtman AH. Investigation of Diacylglycerol Lipase Alpha Inhibition in the Mouse Lipopolysaccharide Inflammatory Pain Model. The Journal of Pharmacology and Experimental Therapeutics. PMID 28970359 DOI: 10.1124/Jpet.117.243808  0.502
2017 Bar-Peled L, Kemper EK, Suciu RM, Vinogradova EV, Backus KM, Horning BD, Paul TA, Ichu TA, Svensson RU, Olucha J, Chang MW, Kok BP, Zhu Z, Ihle NT, Dix MM, ... ... Cravatt BF, et al. Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer. Cell. PMID 28965760 DOI: 10.1016/J.Cell.2017.08.051  0.798
2017 Niessen S, Dix MM, Barbas S, Potter ZE, Lu S, Brodsky O, Planken S, Behenna D, Almaden C, Gajiwala KS, Ryan K, Ferre R, Lazear MR, Hayward MM, Kath JC, ... Cravatt BF, et al. Proteome-wide Map of Targets of T790M-EGFR-Directed Covalent Inhibitors. Cell Chemical Biology. PMID 28965727 DOI: 10.1016/J.Chembiol.2017.08.017  0.623
2017 Lum KM, Sato Y, Beyer BA, Plaisted WC, Anglin JL, Lairson LL, Cravatt BF. Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. Acs Chemical Biology. PMID 28930429 DOI: 10.1021/Acschembio.7B00581  0.405
2017 Schonhoft JD, Monteiro C, Plate L, Eisele YS, Kelly JM, Boland D, Parker CG, Cravatt BF, Teruya S, Helmke S, Maurer M, Berk J, Sekijima Y, Novais M, Coelho T, et al. Peptide probes detect misfolded transthyretin oligomers in plasma of hereditary amyloidosis patients. Science Translational Medicine. 9. PMID 28904227 DOI: 10.1126/Scitranslmed.Aam7621  0.614
2017 Yun B, Lee H, Powell R, Reisdorph N, Ewing H, Gelb MH, Hsu KL, Cravatt BF, Leslie CC. Regulation of calcium release from the endoplasmic reticulum by the serine hydrolase ABHD2. Biochemical and Biophysical Research Communications. PMID 28684316 DOI: 10.1016/J.Bbrc.2017.06.195  0.652
2017 Owens RA, Mustafa MA, Ignatowska-Jankowska BM, Damaj MI, Beardsley PM, Wiley JL, Niphakis MJ, Cravatt BF, Lichtman AH. Inhibition of the endocannabinoid-regulating enzyme monoacylglycerol lipase elicits a CB1 receptor-mediated discriminative stimulus in mice. Neuropharmacology. PMID 28673548 DOI: 10.1016/J.Neuropharm.2017.06.032  0.572
2017 Whitby LR, Obach RS, Simon GM, Hayward MM, Cravatt BF. Quantitative Chemical Proteomic Profiling of the in Vivo Targets of Reactive Drug Metabolites. Acs Chemical Biology. PMID 28636309 DOI: 10.1021/Acschembio.7B00346  0.791
2017 van Esbroeck ACM, Janssen APA, Cognetta AB, Ogasawara D, Shpak G, van der Kroeg M, Kantae V, Baggelaar MP, de Vrij FMS, Deng H, Allarà M, Fezza F, Lin Z, van der Wel T, Soethoudt M, ... ... Cravatt BF, et al. Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474. Science (New York, N.Y.). 356: 1084-1087. PMID 28596366 DOI: 10.1126/Science.Aaf7497  0.425
2017 Kornahrens AF, Cognetta AB, Brody DM, Matthews ML, Cravatt BF, Boger DL. Design of Benzoxathiazin-3-one 1,1-Dioxides as a New Class of Irreversible Serine Hydrolase Inhibitors: Discovery of a Uniquely Selective PNPLA4 Inhibitor. Journal of the American Chemical Society. PMID 28498651 DOI: 10.1021/Jacs.7B02985  0.705
2017 Touchette MH, Van Vlack E, Bai L, Kim J, Cognetta AB, Previti ML, Backus KM, Martin DW, Cravatt BF, Seeliger JC. A Screen for Protein-Protein Interactions in Live Mycobacteria Reveals a Functional Link Between the Virulence-Associated Lipid Transporter LprG and the Mycolyltransferase Antigen 85A. Acs Infectious Diseases. PMID 28276676 DOI: 10.1021/Acsinfecdis.6B00179  0.736
2017 Matthews ML, He L, Horning BD, Olson EJ, Correia BE, Yates JR, Dawson PE, Cravatt BF. Chemoproteomic profiling and discovery of protein electrophiles in human cells. Nature Chemistry. 9: 234-243. PMID 28221344 DOI: 10.1038/Nchem.2645  0.649
2017 Guo CJ, Chang FY, Wyche TP, Backus KM, Acker TM, Funabashi M, Taketani M, Donia MS, Nayfach S, Pollard KS, Craik CS, Cravatt BF, Clardy J, Voigt CA, Fischbach MA. Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases. Cell. PMID 28111075 DOI: 10.1016/J.Cell.2016.12.021  0.733
2017 Parker CG, Galmozzi A, Wang Y, Correia BE, Sasaki K, Joslyn CM, Kim AS, Cavallaro CL, Lawrence RM, Johnson SR, Narvaiza I, Saez E, Cravatt BF. Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. PMID 28111073 DOI: 10.1016/J.Cell.2016.12.029  0.721
2017 Wu C, Vinogradova E, Lao F, Nan E, Ta K, Messer K, Choi M, Cravatt BF, Carson DA. Proteomic Analysis Reveals IRAK4 As a Therapeutic Target in Chronic Lymphocytic Leukemia Blood. 130: 3838-3838. DOI: 10.1182/Blood.V130.Suppl_1.3838.3838  0.597
2017 Bar-Peled L, Kemper E, Cravatt B. Abstract PR16: A druggable transcriptional vulnerability in NRF2-dependent lung cancer Molecular Cancer Therapeutics. 16. DOI: 10.1158/1538-8514.Synthleth-Pr16  0.323
2016 Chen YC, Backus KM, Merkulova M, Yang C, Brown D, Cravatt BF, Zhang C. Covalent Modulators of the Vacuolar ATPase. Journal of the American Chemical Society. PMID 28010062 DOI: 10.1021/Jacs.6B12511  0.746
2016 Sousa-Valente J, Varga A, Torres Perez JV, Jenes A, Wahba J, Mackie K, Cravatt B, Ueda N, Tsuboi K, Santha P, Jancso G, Tailor H, Avelino A, Nagy I. Inflammation of peripheral tissues and injury to peripheral nerves induce diferring effects in the expression of the calcium-sensitive anandamide-synthesising enzyme and related molecules in rat primary sensory neurons. The Journal of Comparative Neurology. PMID 27997038 DOI: 10.1002/Cne.24154  0.305
2016 Deng H, Kooijman S, van den Nieuwendijk AM, Ogasawara D, van der Wel T, van Dalen F, Baggelaar MP, Janssen FJ, van den Berg RJ, den Dulk H, Cravatt BF, Overkleeft HS, Rensen PC, van der Stelt M. Triazole Ureas Act as Diacylglycerol Lipase Inhibitors and Prevent Fasting-Induced Refeeding. Journal of Medicinal Chemistry. PMID 27992221 DOI: 10.1021/Acs.Jmedchem.6B01482  0.422
2016 Zaro BW, Whitby LR, Lum KM, Cravatt BF. Metabolically Labile Fumarate Esters Impart Kinetic Selectivity to Irreversible Inhibitors. Journal of the American Chemical Society. 138: 15841-15844. PMID 27960302 DOI: 10.1021/Jacs.6B10589  0.814
2016 Wilkerson JL, Ghosh S, Mustafa M, Abdullah RA, Niphakis MJ, Cabrera R, Maldonado RL, Cravatt BF, Lichtman AH. The endocannabinoid hydrolysis inhibitor SA-57: Intrinsic antinociceptive effects, augmented morphine-induced antinociception, and attenuated heroin seeking behavior in mice. Neuropharmacology. PMID 27890602 DOI: 10.1016/J.Neuropharm.2016.11.015  0.531
2016 Kory N, Grond S, Kamat SS, Li Z, Krahmer N, Chitraju C, Zhou P, Fröhlich F, Semova I, Ejsing C, Zechner R, Cravatt BF, Farese RV, Walther TC. Mice Lacking Lipid Droplet-Associated Hydrolase, a Gene Linked to Human Prostate Cancer, Have Normal Cholesterol Ester Metabolism. Journal of Lipid Research. PMID 27836991 DOI: 10.1194/Jlr.M072538  0.601
2016 Villa GR, Hulce JJ, Zanca C, Bi J, Ikegami S, Cahill GL, Gu Y, Lum KM, Masui K, Yang H, Rong X, Hong C, Turner KM, Liu F, Hon GC, ... ... Cravatt BF, et al. An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers. Cancer Cell. PMID 27746144 DOI: 10.1016/J.Ccell.2016.09.008  0.33
2016 Horning BD, Suciu RM, Ghadiri DA, Ulanovskaya OA, Matthews ML, Lum KM, Backus KM, Brown SJ, Rosen H, Cravatt BF. Chemical Proteomic Profiling of Human Methyltransferases. Journal of the American Chemical Society. PMID 27689866 DOI: 10.1021/Jacs.6B07830  0.821
2016 Blewett MM, Xie J, Zaro BW, Backus KM, Altman A, Teijaro JR, Cravatt BF. Chemical proteomic map of dimethyl fumarate-sensitive cysteines in primary human T cells. Science Signaling. 9: rs10. PMID 27625306 DOI: 10.1126/Scisignal.Aaf7694  0.794
2016 Grüner BM, Schulze CJ, Yang D, Ogasawara D, Dix MM, Rogers ZN, Chuang CH, McFarland CD, Chiou SH, Brown JM, Cravatt BF, Bogyo M, Winslow MM. An in vivo multiplexed small-molecule screening platform. Nature Methods. PMID 27617390 DOI: 10.1038/Nmeth.3992  0.629
2016 Dugan A, Majmudar CY, Pricer RE, Niessen S, Lancia JK, Fung HY, Cravatt BF, Mapp AK. Discovery of enzymatic targets of transcriptional activators via in vivo covalent chemical capture. Journal of the American Chemical Society. PMID 27611834 DOI: 10.1021/Jacs.6B07680  0.352
2016 Kolar MJ, Kamat SS, Parsons WH, Homan EA, Maher T, Peroni OD, Syed I, Fjeld K, Molven A, Kahn BB, Cravatt BF, Saghatelian A. Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase. Biochemistry. PMID 27509211 DOI: 10.1021/Acs.Biochem.6B00565  0.804
2016 Ogura Y, Parsons WH, Kamat SS, Cravatt BF. A calcium-dependent acyltransferase that produces N-acyl phosphatidylethanolamines. Nature Chemical Biology. PMID 27399000 DOI: 10.1038/Nchembio.2127  0.61
2016 Wiley JL, Lefever TW, Pulley NS, Marusich JA, Cravatt BF, Lichtman AH. Just add water: cannabinoid discrimination in a water T-maze with FAAH(-/-) and FAAH(+/+) mice. Behavioural Pharmacology. 27: 479-484. PMID 27385208 DOI: 10.1097/Fbp.0000000000000228  0.499
2016 Briggs KJ, Koivunen P, Cao S, Backus KM, Olenchock BA, Patel H, Zhang Q, Signoretti S, Gerfen GJ, Richardson AL, Witkiewicz AK, Cravatt BF, Clardy J, Kaelin WG. Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine. Cell. 166: 126-139. PMID 27368101 DOI: 10.1016/J.Cell.2016.05.042  0.7
2016 Backus KM, Correia BE, Lum KM, Forli S, Horning BD, González-Páez GE, Chatterjee S, Lanning BR, Teijaro JR, Olson AJ, Wolan DW, Cravatt BF. Proteome-wide covalent ligand discovery in native biological systems. Nature. PMID 27309814 DOI: 10.1038/Nature18002  0.756
2016 Owens RA, Ignatowska-Jankowska BM, Mustafa M, Beardsley PM, Wiley JL, Jali A, Selley DE, Niphakis M, Cravatt BF, Lichtman AH. Discriminative Stimulus Properties of the Endocannabinoid Catabolic Enzyme Inhibitor SA-57 in Mice. The Journal of Pharmacology and Experimental Therapeutics. PMID 27307500 DOI: 10.1124/Jpet.115.229492  0.578
2016 Chen W, Dong J, Plate L, Mortenson DE, Brighty GJ, Li S, Liu Y, Galmozzi A, Lee PS, Hulce JJ, Cravatt BF, Saez E, Powers ET, Wilson IA, Sharpless KB, et al. Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding-site Tyr Residue. Journal of the American Chemical Society. PMID 27191344 DOI: 10.1021/Jacs.6B02960  0.385
2016 Parsons WH, Kolar MJ, Kamat SS, Iii AB, Hulce JJ, Saez E, Kahn BB, Saghatelian A, Cravatt BF. AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs. Nature Chemical Biology. PMID 27018888 DOI: 10.1038/Nchembio.2051  0.766
2016 Limebeer CL, Rock EM, Puvanenthirarajah N, Niphakis MJ, Cravatt BF, Parker LA. Elevation of 2-AG by monoacylglycerol lipase inhibition in the visceral insular cortex interferes with anticipatory nausea in a rat model. Behavioral Neuroscience. 130: 261-6. PMID 26974857 DOI: 10.1037/Bne0000132  0.321
2016 Wilkerson JL, Ghosh S, Bagdas D, Mason BL, Crowe MS, Hsu KL, Wise LE, Kinsey SG, Damaj MI, Cravatt BF, Lichtman AH. Diacylglycerol lipase beta inhibition reverses nociceptive behavior in mouse models of inflammatory and neuropathic pain. British Journal of Pharmacology. PMID 26915789 DOI: 10.1111/Bph.13469  0.702
2016 Wilkerson JL, Niphakis MJ, Grim TW, Mustafa MA, Abdullah RA, Poklis JL, Dewey WL, Akbarali HI, Banks ML, Wise LE, Cravatt BF, Lichtman AH. The selective monoacylglycerol lipase inhibitor MJN110 produces opioid sparing effects in a mouse neuropathic pain model. The Journal of Pharmacology and Experimental Therapeutics. PMID 26791602 DOI: 10.1124/Jpet.115.229971  0.507
2016 Viader A, Ogasawara D, Joslyn CM, Sanchez-Alavez M, Mori S, Nguyen W, Conti B, Cravatt BF. A chemical proteomic atlas of brain serine hydrolases identifies cell type-specific pathways regulating neuroinflammation. Elife. 5. PMID 26779719 DOI: 10.7554/Elife.12345  0.393
2016 Buczynski MW, Herman MA, Hsu KL, Natividad LA, Irimia C, Polis IY, Pugh H, Chang JW, Niphakis MJ, Cravatt BF, Roberto M, Parsons LH. Diacylglycerol lipase disinhibits VTA dopamine neurons during chronic nicotine exposure. Proceedings of the National Academy of Sciences of the United States of America. PMID 26755579 DOI: 10.1073/pnas.1522672113  0.725
2016 Cravatt BF, Blewett MM, Teijaro JR, VanHook AM. Science SignalingPodcast for 13 September 2016: DMF and the immune system Science Signaling. 9: pc19-pc19. DOI: 10.1126/Scisignal.Aai8956  0.364
2015 Ogasawara D, Deng H, Viader A, Baggelaar MP, Breman A, den Dulk H, van den Nieuwendijk AM, Soethoudt M, van der Wel T, Zhou J, Overkleeft HS, Sanchez-Alavez M, Mo S, Nguyen W, Conti B, ... ... Cravatt BF, et al. Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition. Proceedings of the National Academy of Sciences of the United States of America. PMID 26668358 DOI: 10.1073/Pnas.1522364112  0.397
2015 Janssen FJ, Baggelaar MP, Hummel JJ, Overkleeft HS, Cravatt BF, Boger DL, van der Stelt M. Comprehensive Analysis of Structure Activity Relationships of α-Ketoheterocycles as sn-1-Diacylglycerol Lipase α Inhibitors. Journal of Medicinal Chemistry. PMID 26584396 DOI: 10.1021/Acs.Jmedchem.5B01627  0.504
2015 Panlilio LV, Thorndike EB, Nikas SP, Alapafuja SO, Bandiera T, Cravatt BF, Makriyannis A, Piomelli D, Goldberg SR, Justinova Z. Effects of fatty acid amide hydrolase (FAAH) inhibitors on working memory in rats. Psychopharmacology. PMID 26558620 DOI: 10.1007/S00213-015-4140-6  0.314
2015 Sticht MA, Limebeer CL, Rafla BR, Abdullah RA, Poklis JL, Ho W, Niphakis MJ, Cravatt BF, Sharkey KA, Lichtman AH, Parker LA. Endocannabinoid regulation of nausea is mediated by 2-arachidonoylglycerol (2-AG) in the rat visceral insular cortex. Neuropharmacology. PMID 26541329 DOI: 10.1016/J.Neuropharm.2015.10.039  0.57
2015 Vázquez C, Tolón RM, Grande MT, Caraza M, Moreno M, Koester EC, Villaescusa B, Ruiz-Valdepeñas L, Fernández-Sánchez FJ, Cravatt BF, Hillard CJ, Romero J. Endocannabinoid regulation of amyloid-induced neuroinflammation. Neurobiology of Aging. PMID 26362942 DOI: 10.1016/J.Neurobiolaging.2015.08.003  0.345
2015 Rock EM, Limebeer CL, Ward JM, Cohen A, Grove K, Niphakis MJ, Cravatt BF, Parker LA. Interference with acute nausea and anticipatory nausea in rats by fatty acid amide hydrolase (FAAH) inhibition through a PPARα and CB1 receptor mechanism, respectively: a double dissociation. Psychopharmacology. 232: 3841-8. PMID 26297326 DOI: 10.1007/S00213-015-4050-7  0.325
2015 Sanchez-Alavez M, Nguyen W, Mori S, Moroncini G, Viader A, Nomura DK, Cravatt BF, Conti B. Monoacylglycerol Lipase Regulates Fever Response. Plos One. 10: e0134437. PMID 26287872 DOI: 10.1371/Journal.Pone.0134437  0.614
2015 Craney A, Dix MM, Adhikary R, Cravatt BF, Romesberg FE. An Alternative Terminal Step of the General Secretory Pathway in Staphylococcus aureus. Mbio. 6. PMID 26286693 DOI: 10.1128/Mbio.01178-15  0.637
2015 Viader A, Blankman JL, Zhong P, Liu X, Schlosburg JE, Joslyn CM, Liu QS, Tomarchio AJ, Lichtman AH, Selley DE, Sim-Selley LJ, Cravatt BF. Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action. Cell Reports. PMID 26212325 DOI: 10.1016/J.Celrep.2015.06.075  0.528
2015 Cognetta AB, Niphakis MJ, Lee HC, Martini ML, Hulce JJ, Cravatt BF. Selective N-Hydroxyhydantoin Carbamate Inhibitors of Mammalian Serine Hydrolases. Chemistry & Biology. PMID 26120000 DOI: 10.1016/J.Chembiol.2015.05.018  0.442
2015 Niphakis MJ, Lum KM, Cognetta AB, Correia BE, Ichu TA, Olucha J, Brown SJ, Kundu S, Piscitelli F, Rosen H, Cravatt BF. A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 161: 1668-80. PMID 26091042 DOI: 10.1016/J.Cell.2015.05.045  0.375
2015 Baggelaar MP, Chameau PJ, Kantae V, Hummel J, Hsu KL, Janssen F, van der Wel T, Soethoudt M, Deng H, den Dulk H, Allarà M, Florea BI, Di Marzo V, Wadman WJ, Kruse CG, ... ... Cravatt BF, et al. Highly Selective, Reversible Inhibitor Identified by Comparative Chemoproteomics Modulates Diacylglycerol Lipase Activity in Neurons. Journal of the American Chemical Society. 137: 8851-7. PMID 26083464 DOI: 10.1021/Jacs.5B04883  0.73
2015 Schreiber SL, Kotz JD, Li M, Aubé J, Austin CP, Reed JC, Rosen H, White EL, Sklar LA, Lindsley CW, Alexander BR, Bittker JA, Clemons PA, de Souza A, Foley MA, ... ... Cravatt BF, et al. Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes. Cell. 161: 1252-1265. PMID 26046436 DOI: 10.1016/J.Cell.2015.05.023  0.316
2015 Ghosh S, Kinsey SG, Liu QS, Hruba L, McMahon LR, Grim TW, Merritt CR, Wise LE, Abdullah RA, Selley DE, Sim-Selley LJ, Cravatt BF, Lichtman AH. Full Fatty Acid Amide Hydrolase Inhibition Combined with Partial Monoacylglycerol Lipase Inhibition: Augmented and Sustained Antinociceptive Effects with Reduced Cannabimimetic Side Effects in Mice. The Journal of Pharmacology and Experimental Therapeutics. 354: 111-20. PMID 25998048 DOI: 10.1124/Jpet.115.222851  0.583
2015 Kohnz RA, Mulvihill MM, Chang JW, Hsu KL, Sorrentino A, Cravatt BF, Bandyopadhyay S, Goga A, Nomura DK. Activity-Based Protein Profiling of Oncogene-Driven Changes in Metabolism Reveals Broad Dysregulation of PAFAH1B2 and 1B3 in Cancer. Acs Chemical Biology. 10: 1624-30. PMID 25945974 DOI: 10.1021/Acschembio.5B00053  0.8
2015 Vázquez C, Tolón RM, Pazos MR, Moreno M, Koester EC, Cravatt BF, Hillard CJ, Romero J. Endocannabinoids regulate the activity of astrocytic hemichannels and the microglial response against an injury: In vivo studies. Neurobiology of Disease. 79: 41-50. PMID 25917763 DOI: 10.1016/J.Nbd.2015.04.005  0.339
2015 Lee HC, Simon GM, Cravatt BF. ABHD4 regulates multiple classes of N-acyl phospholipids in the mammalian central nervous system. Biochemistry. 54: 2539-49. PMID 25853435 DOI: 10.1021/Acs.Biochem.5B00207  0.636
2015 Ignatowska-Jankowska B, Wilkerson JL, Mustafa M, Abdullah R, Niphakis M, Wiley JL, Cravatt BF, Lichtman AH. Selective monoacylglycerol lipase inhibitors: antinociceptive versus cannabimimetic effects in mice. The Journal of Pharmacology and Experimental Therapeutics. 353: 424-32. PMID 25762694 DOI: 10.1124/Jpet.114.222315  0.552
2015 Dincheva I, Drysdale AT, Hartley CA, Johnson DC, Jing D, King EC, Ra S, Gray JM, Yang R, DeGruccio AM, Huang C, Cravatt BF, Glatt CE, Hill MN, Casey BJ, et al. FAAH genetic variation enhances fronto-amygdala function in mouse and human. Nature Communications. 6: 6395. PMID 25731744 DOI: 10.1038/Ncomms7395  0.568
2015 Nass SR, Long JZ, Schlosburg JE, Cravatt BF, Lichtman AH, Kinsey SG. Endocannabinoid Catabolic Enzymes Play Differential Roles in Thermal Homeostasis in Response to Environmental or Immune Challenge. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 10: 364-70. PMID 25715681 DOI: 10.1007/S11481-015-9593-1  0.743
2015 Hruba L, Seillier A, Zaki A, Cravatt BF, Lichtman AH, Giuffrida A, McMahon LR. Simultaneous inhibition of fatty acid amide hydrolase and monoacylglycerol lipase shares discriminative stimulus effects with Δ9-tetrahydrocannabinol in mice. The Journal of Pharmacology and Experimental Therapeutics. 353: 261-8. PMID 25711338 DOI: 10.1124/Jpet.115.222836  0.544
2015 Adachi S, Cognetta AB, Niphakis MJ, He Z, Zajdlik A, St Denis JD, Scully CC, Cravatt BF, Yudin AK. Facile synthesis of borofragments and their evaluation in activity-based protein profiling. Chemical Communications (Cambridge, England). 51: 3608-11. PMID 25633248 DOI: 10.1039/C4Cc09107H  0.407
2015 Chang JW, Zuhl AM, Speers AE, Niessen S, Brown SJ, Mulvihill MM, Fan YC, Spicer TP, Southern M, Scampavia L, Fernandez-Vega V, Dix MM, Cameron MD, Hodder PS, Rosen H, ... ... Cravatt BF, et al. Selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3 that impairs cancer cell survival. Acs Chemical Biology. 10: 925-32. PMID 25602368 DOI: 10.1021/Cb500893Q  0.8
2015 Kamat SS, Camara K, Parsons WH, Chen DH, Dix MM, Bird TD, Howell AR, Cravatt BF. Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay. Nature Chemical Biology. 11: 164-71. PMID 25580854 DOI: 10.1038/Nchembio.1721  0.758
2015 Camara K, Kamat SS, Lasota CC, Cravatt BF, Howell AR. Combining cross-metathesis and activity-based protein profiling: new β-lactone motifs for targeting serine hydrolases. Bioorganic & Medicinal Chemistry Letters. 25: 317-21. PMID 25541002 DOI: 10.1016/J.Bmcl.2014.11.038  0.644
2015 Gamage TF, Ignatowska-Jankowska BM, Muldoon PP, Cravatt BF, Damaj MI, Lichtman AH. Differential effects of endocannabinoid catabolic inhibitors on morphine withdrawal in mice. Drug and Alcohol Dependence. 146: 7-16. PMID 25479915 DOI: 10.1016/J.Drugalcdep.2014.11.015  0.557
2015 Zhao N, Darby CM, Small J, Bachovchin DA, Jiang X, Burns-Huang KE, Botella H, Ehrt S, Boger DL, Anderson ED, Cravatt BF, Speers AE, Fernandez-Vega V, Hodder PS, Eberhart C, et al. Target-based screen against a periplasmic serine protease that regulates intrabacterial pH homeostasis in Mycobacterium tuberculosis. Acs Chemical Biology. 10: 364-71. PMID 25457457 DOI: 10.1021/Cb500746Z  0.736
2015 Wiebelhaus JM, Grim TW, Owens RA, Lazenka MF, Sim-Selley LJ, Abdullah RA, Niphakis MJ, Vann RE, Cravatt BF, Wiley JL, Negus SS, Lichtman AH. Δ9-tetrahydrocannabinol and endocannabinoid degradative enzyme inhibitors attenuate intracranial self-stimulation in mice. The Journal of Pharmacology and Experimental Therapeutics. 352: 195-207. PMID 25398241 DOI: 10.1124/Jpet.114.218677  0.581
2015 Muldoon PP, Chen J, Harenza JL, Abdullah RA, Sim-Selley LJ, Cravatt BF, Miles MF, Chen X, Lichtman AH, Damaj MI. Inhibition of monoacylglycerol lipase reduces nicotine withdrawal. British Journal of Pharmacology. 172: 869-82. PMID 25258021 DOI: 10.1111/Bph.12948  0.51
2015 Zhang Z, Wang W, Zhong P, Liu SJ, Long JZ, Zhao L, Gao HQ, Cravatt BF, Liu QS. Blockade of 2-arachidonoylglycerol hydrolysis produces antidepressant-like effects and enhances adult hippocampal neurogenesis and synaptic plasticity. Hippocampus. 25: 16-26. PMID 25131612 DOI: 10.1002/Hipo.22344  0.616
2015 Parker LA, Niphakis MJ, Downey R, Limebeer CL, Rock EM, Sticht MA, Morris H, Abdullah RA, Lichtman AH, Cravatt BF. Effect of selective inhibition of monoacylglycerol lipase (MAGL) on acute nausea, anticipatory nausea, and vomiting in rats and Suncus murinus. Psychopharmacology. 232: 583-93. PMID 25085768 DOI: 10.1007/S00213-014-3696-X  0.503
2015 Viader A, Ogasawara D, Joslyn CM, Sanchez-Alavez M, Mori S, Nguyen W, Conti B, Cravatt BF. Author response: A chemical proteomic atlas of brain serine hydrolases identifies cell type-specific pathways regulating neuroinflammation Elife. DOI: 10.7554/Elife.12345.017  0.317
2015 Owens R, Beardsley P, cravatt B, Lichtman A. Dual blockade of endocannabinoid hydrolyzing enzymes reveal a CB 1 receptor-mediated interoceptive stimulus Drug and Alcohol Dependence. 156: e168. DOI: 10.1016/J.Drugalcdep.2015.07.456  0.533
2014 Galmozzi A, Sonne SB, Altshuler-Keylin S, Hasegawa Y, Shinoda K, Luijten IH, Chang JW, Sharp LZ, Cravatt BF, Saez E, Kajimura S. ThermoMouse: an in vivo model to identify modulators of UCP1 expression in brown adipose tissue. Cell Reports. 9: 1584-93. PMID 25466254 DOI: 10.1016/J.Celrep.2014.10.066  0.52
2014 Manna JD, Wepy JA, Hsu KL, Chang JW, Cravatt BF, Marnett LJ. Identification of the major prostaglandin glycerol ester hydrolase in human cancer cells. The Journal of Biological Chemistry. 289: 33741-53. PMID 25301951 DOI: 10.1074/Jbc.M114.582353  0.741
2014 Inloes JM, Hsu KL, Dix MM, Viader A, Masuda K, Takei T, Wood MR, Cravatt BF. The hereditary spastic paraplegia-related enzyme DDHD2 is a principal brain triglyceride lipase. Proceedings of the National Academy of Sciences of the United States of America. 111: 14924-9. PMID 25267624 DOI: 10.1073/Pnas.1413706111  0.785
2014 Grim TW, Ghosh S, Hsu KL, Cravatt BF, Kinsey SG, Lichtman AH. Combined inhibition of FAAH and COX produces enhanced anti-allodynic effects in mouse neuropathic and inflammatory pain models. Pharmacology, Biochemistry, and Behavior. 124: 405-11. PMID 25058512 DOI: 10.1016/J.Pbb.2014.07.008  0.723
2014 Kambe T, Correia BE, Niphakis MJ, Cravatt BF. Mapping the protein interaction landscape for fully functionalized small-molecule probes in human cells. Journal of the American Chemical Society. 136: 10777-82. PMID 25045785 DOI: 10.1021/Ja505517T  0.317
2014 Lanning BR, Whitby LR, Dix MM, Douhan J, Gilbert AM, Hett EC, Johnson TO, Joslyn C, Kath JC, Niessen S, Roberts LR, Schnute ME, Wang C, Hulce JJ, Wei B, ... ... Cravatt BF, et al. A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors. Nature Chemical Biology. 10: 760-7. PMID 25038787 DOI: 10.1038/Nchembio.1582  0.809
2014 Naydenov AV, Horne EA, Cheah CS, Swinney K, Hsu KL, Cao JK, Marrs WR, Blankman JL, Tu S, Cherry AE, Fung S, Wen A, Li W, Saporito MS, Selley DE, ... Cravatt BF, et al. ABHD6 blockade exerts antiepileptic activity in PTZ-induced seizures and in spontaneous seizures in R6/2 mice. Neuron. 83: 361-71. PMID 25033180 DOI: 10.1016/J.Neuron.2014.06.030  0.643
2014 Niphakis MJ, Cravatt BF. Enzyme inhibitor discovery by activity-based protein profiling. Annual Review of Biochemistry. 83: 341-77. PMID 24905785 DOI: 10.1146/Annurev-Biochem-060713-035708  0.47
2014 Schlosburg JE, Kinsey SG, Ignatowska-Jankowska B, Ramesh D, Abdullah RA, Tao Q, Booker L, Long JZ, Selley DE, Cravatt BF, Lichtman AH. Prolonged monoacylglycerol lipase blockade causes equivalent cannabinoid receptor type 1 receptor-mediated adaptations in fatty acid amide hydrolase wild-type and knockout mice. The Journal of Pharmacology and Experimental Therapeutics. 350: 196-204. PMID 24849924 DOI: 10.1124/Jpet.114.212753  0.752
2014 Rajagopalan S, Wang C, Yu K, Kuzin AP, Richter F, Lew S, Miklos AE, Matthews ML, Seetharaman J, Su M, Hunt JF, Cravatt BF, Baker D. Design of activated serine-containing catalytic triads with atomic-level accuracy. Nature Chemical Biology. 10: 386-91. PMID 24705591 DOI: 10.1038/Nchembio.1498  0.684
2014 Dix MM, Simon GM, Cravatt BF. Global identification of caspase substrates using PROTOMAP (protein topography and migration analysis platform). Methods in Molecular Biology (Clifton, N.J.). 1133: 61-70. PMID 24567094 DOI: 10.1007/978-1-4939-0357-3_3  0.745
2014 Galmozzi A, Dominguez E, Cravatt BF, Saez E. Application of activity-based protein profiling to study enzyme function in adipocytes. Methods in Enzymology. 538: 151-69. PMID 24529438 DOI: 10.1016/B978-0-12-800280-3.00009-8  0.442
2014 Zhong P, Wang W, Pan B, Liu X, Zhang Z, Long JZ, Zhang HT, Cravatt BF, Liu QS. Monoacylglycerol lipase inhibition blocks chronic stress-induced depressive-like behaviors via activation of mTOR signaling. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 1763-76. PMID 24476943 DOI: 10.1038/Npp.2014.24  0.626
2014 Otrubova K, Cravatt BF, Boger DL. Design, synthesis, and characterization of α-ketoheterocycles that additionally target the cytosolic port Cys269 of fatty acid amide hydrolase. Journal of Medicinal Chemistry. 57: 1079-89. PMID 24456116 DOI: 10.1021/Jm401820Q  0.556
2014 Lajkiewicz NJ, Cognetta AB, Niphakis MJ, Cravatt BF, Porco JA. Remodeling natural products: chemistry and serine hydrolase activity of a rocaglate-derived β-lactone. Journal of the American Chemical Society. 136: 2659-64. PMID 24447064 DOI: 10.1021/Ja412431G  0.419
2014 Dominguez E, Galmozzi A, Chang JW, Hsu KL, Pawlak J, Li W, Godio C, Thomas J, Partida D, Niessen S, O'Brien PE, Russell AP, Watt MJ, Nomura DK, Cravatt BF, et al. Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes. Nature Chemical Biology. 10: 113-21. PMID 24362705 DOI: 10.1038/Nchembio.1429  0.8
2014 Yun B, Lee H, Ghosh M, Cravatt BF, Hsu KL, Bonventre JV, Ewing H, Gelb MH, Leslie CC. Serine hydrolase inhibitors block necrotic cell death by preventing calcium overload of the mitochondria and permeability transition pore formation. The Journal of Biological Chemistry. 289: 1491-504. PMID 24297180 DOI: 10.1074/Jbc.M113.497651  0.655
2014 Wang C, Weerapana E, Blewett MM, Cravatt BF. A chemoproteomic platform to quantitatively map targets of lipid-derived electrophiles. Nature Methods. 11: 79-85. PMID 24292485 DOI: 10.1038/Nmeth.2759  0.708
2014 Dainese E, De Fabritiis G, Sabatucci A, Oddi S, Angelucci CB, Di Pancrazio C, Giorgino T, Stanley N, Del Carlo M, Cravatt BF, Maccarrone M. Membrane lipids are key modulators of the endocannabinoid-hydrolase FAAH. The Biochemical Journal. 457: 463-72. PMID 24215562 DOI: 10.1042/Bj20130960  0.349
2014 Ignatowska-Jankowska BM, Ghosh S, Crowe MS, Kinsey SG, Niphakis MJ, Abdullah RA, Tao Q, O' Neal ST, Walentiny DM, Wiley JL, Cravatt BF, Lichtman AH. In vivo characterization of the highly selective monoacylglycerol lipase inhibitor KML29: antinociceptive activity without cannabimimetic side effects. British Journal of Pharmacology. 171: 1392-407. PMID 23848221 DOI: 10.1111/Bph.12298  0.57
2014 Kinsey S, Nass S, Cravatt B, Lichtman A. 35. Differential effects of endocannabinoid catabolic enzyme inhibition on thermal homeostasis following environmental or immunological stressors Brain, Behavior, and Immunity. 40: e11. DOI: 10.1016/J.Bbi.2014.06.055  0.572
2013 Ward J, Spath SN, Pabst B, Carpino PA, Ruggeri RB, Xing G, Speers AE, Cravatt BF, Ahn K. Mechanistic characterization of a 2-thioxanthine myeloperoxidase inhibitor and selectivity assessment utilizing click chemistry--activity-based protein profiling. Biochemistry. 52: 9187-201. PMID 24320749 DOI: 10.1021/Bi401354D  0.78
2013 Ismail HM, O'Neill PM, Hong DW, Finn RD, Henderson CJ, Wright AT, Cravatt BF, Hemingway J, Paine MJ. Pyrethroid activity-based probes for profiling cytochrome P450 activities associated with insecticide interactions. Proceedings of the National Academy of Sciences of the United States of America. 110: 19766-71. PMID 24248381 DOI: 10.1073/Pnas.1320185110  0.652
2013 Hsu KL, Tsuboi K, Chang JW, Whitby LR, Speers AE, Pugh H, Cravatt BF. Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of α/β-hydrolase domain containing 6 (ABHD6). Journal of Medicinal Chemistry. 56: 8270-9. PMID 24152295 DOI: 10.1021/Jm400899C  0.819
2013 Hsu KL, Tsuboi K, Whitby LR, Speers AE, Pugh H, Inloes J, Cravatt BF. Development and optimization of piperidyl-1,2,3-triazole ureas as selective chemical probes of endocannabinoid biosynthesis. Journal of Medicinal Chemistry. 56: 8257-69. PMID 24152245 DOI: 10.1021/Jm400898X  0.827
2013 Thomas G, Betters JL, Lord CC, Brown AL, Marshall S, Ferguson D, Sawyer J, Davis MA, Melchior JT, Blume LC, Howlett AC, Ivanova PT, Milne SB, Myers DS, Mrak I, ... ... Cravatt BF, et al. The serine hydrolase ABHD6 Is a critical regulator of the metabolic syndrome. Cell Reports. 5: 508-20. PMID 24095738 DOI: 10.1016/J.Celrep.2013.08.047  0.356
2013 Holly SP, Chang JW, Li W, Niessen S, Phillips RM, Piatt R, Black JL, Smith MC, Boulaftali Y, Weyrich AS, Bergmeier W, Cravatt BF, Parise LV. Chemoproteomic discovery of AADACL1 as a regulator of human platelet activation. Chemistry & Biology. 20: 1125-34. PMID 23993462 DOI: 10.1016/J.Chembiol.2013.07.011  0.548
2013 Nomura DK, Cravatt BF. Lipid metabolism in cancer. Biochimica Et Biophysica Acta. 1831: 1497-8. PMID 23921253 DOI: 10.1016/J.Bbalip.2013.08.001  0.554
2013 Moellering RE, Cravatt BF. Functional lysine modification by an intrinsically reactive primary glycolytic metabolite. Science (New York, N.Y.). 341: 549-53. PMID 23908237 DOI: 10.1126/Science.1238327  0.758
2013 Lowery CA, Matamouros S, Niessen S, Zhu J, Scolnick J, Lively JM, Cravatt BF, Miller SI, Kaufmann GF, Janda KD. A chemical biology approach to interrogate quorum-sensing regulated behaviors at the molecular and cellular level. Chemistry & Biology. 20: 903-11. PMID 23890008 DOI: 10.1016/J.Chembiol.2013.05.009  0.355
2013 Niphakis MJ, Cognetta AB, Chang JW, Buczynski MW, Parsons LH, Byrne F, Burston JJ, Chapman V, Cravatt BF. Evaluation of NHS carbamates as a potent and selective class of endocannabinoid hydrolase inhibitors. Acs Chemical Neuroscience. 4: 1322-32. PMID 23731016 DOI: 10.1021/Cn400116Z  0.623
2013 Chang JW, Cognetta AB, Niphakis MJ, Cravatt BF. Proteome-wide reactivity profiling identifies diverse carbamate chemotypes tuned for serine hydrolase inhibition. Acs Chemical Biology. 8: 1590-9. PMID 23701408 DOI: 10.1021/Cb400261H  0.622
2013 Li J, Cisar JS, Zhou CY, Vera B, Williams H, Rodríguez AD, Cravatt BF, Romo D. Simultaneous structure-activity studies and arming of natural products by C-H amination reveal cellular targets of eupalmerin acetate. Nature Chemistry. 5: 510-7. PMID 23695633 DOI: 10.1038/Nchem.1653  0.568
2013 Pryce G, Cabranes A, Fernández-Ruiz J, Bisogno T, Di Marzo V, Long JZ, Cravatt BF, Giovannoni G, Baker D. Control of experimental spasticity by targeting the degradation of endocannabinoids using selective fatty acid amide hydrolase inhibitors. Multiple Sclerosis (Houndmills, Basingstoke, England). 19: 1896-904. PMID 23625705 DOI: 10.1177/1352458513485982  0.72
2013 Gu C, Shannon DA, Colby T, Wang Z, Shabab M, Kumari S, Villamor JG, McLaughlin CJ, Weerapana E, Kaiser M, Cravatt BF, van der Hoorn RA. Chemical proteomics with sulfonyl fluoride probes reveals selective labeling of functional tyrosines in glutathione transferases. Chemistry & Biology. 20: 541-8. PMID 23601643 DOI: 10.1016/J.Chembiol.2013.01.016  0.643
2013 Otrubova K, Brown M, McCormick MS, Han GW, O'Neal ST, Cravatt BF, Stevens RC, Lichtman AH, Boger DL. Rational design of fatty acid amide hydrolase inhibitors that act by covalently bonding to two active site residues. Journal of the American Chemical Society. 135: 6289-99. PMID 23581831 DOI: 10.1021/Ja4014997  0.673
2013 Komatsu T, Hanaoka K, Adibekian A, Yoshioka K, Terai T, Ueno T, Kawaguchi M, Cravatt BF, Nagano T. Diced electrophoresis gel assay for screening enzymes with specified activities. Journal of the American Chemical Society. 135: 6002-5. PMID 23581642 DOI: 10.1021/Ja401792D  0.39
2013 Blankman JL, Cravatt BF. Chemical probes of endocannabinoid metabolism. Pharmacological Reviews. 65: 849-71. PMID 23512546 DOI: 10.1124/Pr.112.006387  0.366
2013 Simon GM, Niphakis MJ, Cravatt BF. Determining target engagement in living systems. Nature Chemical Biology. 9: 200-5. PMID 23508173 DOI: 10.1038/Nchembio.1211  0.637
2013 Deng X, Weerapana E, Ulanovskaya O, Sun F, Liang H, Ji Q, Ye Y, Fu Y, Zhou L, Li J, Zhang H, Wang C, Alvarez S, Hicks LM, Lan L, ... ... Cravatt BF, et al. Proteome-wide quantification and characterization of oxidation-sensitive cysteines in pathogenic bacteria. Cell Host & Microbe. 13: 358-70. PMID 23498960 DOI: 10.1016/J.Chom.2013.02.004  0.664
2013 Ulanovskaya OA, Zuhl AM, Cravatt BF. NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink. Nature Chemical Biology. 9: 300-6. PMID 23455543 DOI: 10.1038/Nchembio.1204  0.3
2013 Kinsey SG, Wise LE, Ramesh D, Abdullah R, Selley DE, Cravatt BF, Lichtman AH. Repeated low-dose administration of the monoacylglycerol lipase inhibitor JZL184 retains cannabinoid receptor type 1-mediated antinociceptive and gastroprotective effects. The Journal of Pharmacology and Experimental Therapeutics. 345: 492-501. PMID 23412396 DOI: 10.1124/Jpet.112.201426  0.512
2013 Hulce JJ, Cognetta AB, Niphakis MJ, Tully SE, Cravatt BF. Proteome-wide mapping of cholesterol-interacting proteins in mammalian cells. Nature Methods. 10: 259-64. PMID 23396283 DOI: 10.1038/Nmeth.2368  0.379
2013 French JB, Zhao H, An S, Niessen S, Deng Y, Cravatt BF, Benkovic SJ. Hsp70/Hsp90 chaperone machinery is involved in the assembly of the purinosome. Proceedings of the National Academy of Sciences of the United States of America. 110: 2528-33. PMID 23359685 DOI: 10.1073/Pnas.1300173110  0.339
2013 Ramesh D, Gamage TF, Vanuytsel T, Owens RA, Abdullah RA, Niphakis MJ, Shea-Donohue T, Cravatt BF, Lichtman AH. Dual inhibition of endocannabinoid catabolic enzymes produces enhanced antiwithdrawal effects in morphine-dependent mice. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 1039-49. PMID 23303065 DOI: 10.1038/Npp.2012.269  0.547
2013 Blankman JL, Long JZ, Trauger SA, Siuzdak G, Cravatt BF. ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC. Proceedings of the National Academy of Sciences of the United States of America. 110: 1500-5. PMID 23297193 DOI: 10.1073/Pnas.1217121110  0.662
2013 Cao Z, Mulvihill MM, Mukhopadhyay P, Xu H, Erdélyi K, Hao E, Holovac E, Haskó G, Cravatt BF, Nomura DK, Pacher P. Monoacylglycerol lipase controls endocannabinoid and eicosanoid signaling and hepatic injury in mice. Gastroenterology. 144: 808-817.e15. PMID 23295443 DOI: 10.1053/J.Gastro.2012.12.028  0.73
2013 Nagano JM, Hsu KL, Whitby LR, Niphakis MJ, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Hodder P, Srinivasan P, Gonzalez TD, Rosen H, Bahnson BJ, Cravatt BF. Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A(2). Bioorganic & Medicinal Chemistry Letters. 23: 839-43. PMID 23260346 DOI: 10.1016/J.Bmcl.2012.11.061  0.797
2013 Bisogno T, Mahadevan A, Coccurello R, Chang JW, Allarà M, Chen Y, Giacovazzo G, Lichtman A, Cravatt B, Moles A, Di Marzo V. A novel fluorophosphonate inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol with potential anti-obesity effects British Journal of Pharmacology. 169: 784-793. PMID 23072382 DOI: 10.1111/Bph.12013  0.644
2013 Ramya TN, Weerapana E, Cravatt BF, Paulson JC. Glycoproteomics enabled by tagging sialic acid- or galactose-terminated glycans. Glycobiology. 23: 211-21. PMID 23070960 DOI: 10.1093/Glycob/Cws144  0.617
2013 Ghosh S, Wise LE, Chen Y, Gujjar R, Mahadevan A, Cravatt BF, Lichtman AH. The monoacylglycerol lipase inhibitor JZL184 suppresses inflammatory pain in the mouse carrageenan model. Life Sciences. 92: 498-505. PMID 22749865 DOI: 10.1016/J.Lfs.2012.06.020  0.529
2012 Lenglet S, Thomas A, Soehnlein O, Montecucco F, Burger F, Pelli G, Galan K, Cravatt B, Staub C, Steffens S. Fatty acid amide hydrolase deficiency enhances intraplaque neutrophil recruitment in atherosclerotic mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 215-23. PMID 23241405 DOI: 10.1161/Atvbaha.112.300275  0.357
2012 Hsu KL, Tsuboi K, Adibekian A, Pugh H, Masuda K, Cravatt BF. DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses. Nature Chemical Biology. 8: 999-1007. PMID 23103940 DOI: 10.1038/Nchembio.1105  0.703
2012 Benjamin DI, Cravatt BF, Nomura DK. Global profiling strategies for mapping dysregulated metabolic pathways in cancer. Cell Metabolism. 16: 565-77. PMID 23063552 DOI: 10.1016/J.Cmet.2012.09.013  0.775
2012 Palumbo-Zerr K, Horn A, Distler A, Zerr P, Dees C, Beyer C, Selvi E, Cravatt BF, Distler O, Schett G, Distler JH. Inactivation of fatty acid amide hydrolase exacerbates experimental fibrosis by enhanced endocannabinoid-mediated activation of CB1. Annals of the Rheumatic Diseases. 71: 2051-4. PMID 22915616 DOI: 10.1136/Annrheumdis-2012-201823  0.371
2012 Liu X, Dix M, Speers AE, Bachovchin DA, Zuhl AM, Cravatt BF, Kodadek TJ. Rapid development of a potent photo-triggered inhibitor of the serine hydrolase RBBP9. Chembiochem : a European Journal of Chemical Biology. 13: 2082-93. PMID 22907802 DOI: 10.1002/Cbic.201200445  0.825
2012 Di Venere A, Dainese E, Fezza F, Angelucci BC, Rosato N, Cravatt BF, Finazzi-Agrò A, Mei G, Maccarrone M. Rat and human fatty acid amide hydrolases: overt similarities and hidden differences. Biochimica Et Biophysica Acta. 1821: 1425-33. PMID 22877990 DOI: 10.1016/J.Bbalip.2012.07.021  0.417
2012 Niphakis MJ, Johnson DS, Ballard TE, Stiff C, Cravatt BF. O-hydroxyacetamide carbamates as a highly potent and selective class of endocannabinoid hydrolase inhibitors. Acs Chemical Neuroscience. 3: 418-26. PMID 22860211 DOI: 10.1021/Cn200089J  0.426
2012 Wiskerke J, Irimia C, Cravatt BF, De Vries TJ, Schoffelmeer AN, Pattij T, Parsons LH. Characterization of the effects of reuptake and hydrolysis inhibition on interstitial endocannabinoid levels in the brain: an in vivo microdialysis study. Acs Chemical Neuroscience. 3: 407-17. PMID 22860210 DOI: 10.1021/Cn300036B  0.33
2012 Tai T, Tsuboi K, Uyama T, Masuda K, Cravatt BF, Houchi H, Ueda N. Endogenous molecules stimulating N-acylethanolamine-hydrolyzing acid amidase (NAAA). Acs Chemical Neuroscience. 3: 379-85. PMID 22860206 DOI: 10.1021/Cn300007S  0.4
2012 Wise LE, Long KA, Abdullah RA, Long JZ, Cravatt BF, Lichtman AH. Dual fatty acid amide hydrolase and monoacylglycerol lipase blockade produces THC-like Morris water maze deficits in mice. Acs Chemical Neuroscience. 3: 369-78. PMID 22860205 DOI: 10.1021/Cn200130S  0.709
2012 Kaczocha M, Lin Q, Nelson LD, McKinney MK, Cravatt BF, London E, Deutsch DG. Anandamide externally added to lipid vesicles containing trapped fatty acid amide hydrolase (FAAH) is readily hydrolyzed in a sterol-modulated fashion. Acs Chemical Neuroscience. 3: 364-8. PMID 22860204 DOI: 10.1021/Cn300001W  0.751
2012 Dix MM, Simon GM, Wang C, Okerberg E, Patricelli MP, Cravatt BF. Functional interplay between caspase cleavage and phosphorylation sculpts the apoptotic proteome. Cell. 150: 426-40. PMID 22817901 DOI: 10.1016/J.Cell.2012.05.040  0.783
2012 Saario SM, McKinney MK, Speers AE, Wang C, Cravatt BF. Clickable, photoreactive inhibitors to probe the active site microenvironment of fatty acid amide hydrolase(). Chemical Science (Royal Society of Chemistry : 2010). 3: 77-83. PMID 22737400 DOI: 10.1039/C1Sc00336D  0.815
2012 Adibekian A, Martin BR, Chang JW, Hsu KL, Tsuboi K, Bachovchin DA, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Hodder PS, Rosen H, Cravatt BF. Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes. Journal of the American Chemical Society. 134: 10345-8. PMID 22690931 DOI: 10.1021/Ja303400U  0.831
2012 Cisar JS, Cravatt BF. Fully functionalized small-molecule probes for integrated phenotypic screening and target identification. Journal of the American Chemical Society. 134: 10385-8. PMID 22667687 DOI: 10.1021/Ja304213W  0.395
2012 Skaddan MB, Zhang L, Johnson DS, Zhu A, Zasadny KR, Coelho RV, Kuszpit K, Currier G, Fan KH, Beck EM, Chen L, Drozda SE, Balan G, Niphakis M, Cravatt BF, et al. The synthesis and in vivo evaluation of [18F]PF-9811: a novel PET ligand for imaging brain fatty acid amide hydrolase (FAAH). Nuclear Medicine and Biology. 39: 1058-67. PMID 22571907 DOI: 10.1016/J.Nucmedbio.2012.03.011  0.307
2012 Chang JW, Niphakis MJ, Lum KM, Cognetta AB, Wang C, Matthews ML, Niessen S, Buczynski MW, Parsons LH, Cravatt BF. Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. Chemistry & Biology. 19: 579-88. PMID 22542104 DOI: 10.1016/J.Chembiol.2012.03.009  0.75
2012 Dillon MB, Bachovchin DA, Brown SJ, Finn MG, Rosen H, Cravatt BF, Mowen KA. Novel inhibitors for PRMT1 discovered by high-throughput screening using activity-based fluorescence polarization. Acs Chemical Biology. 7: 1198-204. PMID 22506763 DOI: 10.1021/Cb300024C  0.393
2012 Zuhl AM, Mohr JT, Bachovchin DA, Niessen S, Hsu KL, Berlin JM, Dochnahl M, López-Alberca MP, Fu GC, Cravatt BF. Competitive activity-based protein profiling identifies aza-β-lactams as a versatile chemotype for serine hydrolase inhibition. Journal of the American Chemical Society. 134: 5068-71. PMID 22400490 DOI: 10.1021/Ja300799T  0.741
2012 Benito C, Tolón RM, Castillo AI, Ruiz-Valdepeñas L, Martínez-Orgado JA, Fernández-Sánchez FJ, Vázquez C, Cravatt BF, Romero J. β-Amyloid exacerbates inflammation in astrocytes lacking fatty acid amide hydrolase through a mechanism involving PPAR-α, PPAR-γ and TRPV1, but not CB₁ or CBâ‚‚ receptors. British Journal of Pharmacology. 166: 1474-89. PMID 22321194 DOI: 10.1111/J.1476-5381.2012.01889.X  0.333
2012 Moellering RE, Cravatt BF. How chemoproteomics can enable drug discovery and development. Chemistry & Biology. 19: 11-22. PMID 22284350 DOI: 10.1016/J.Chembiol.2012.01.001  0.72
2012 Yu PT, Babicky M, Jaquish D, French R, Marayuma K, Mose E, Niessen S, Hoover H, Shields D, Cheresh D, Cravatt BF, Lowy AM. The RON-receptor regulates pancreatic cancer cell migration through phosphorylation-dependent breakdown of the hemidesmosome. International Journal of Cancer. Journal International Du Cancer. 131: 1744-54. PMID 22275185 DOI: 10.1002/Ijc.27447  0.352
2012 Bachovchin DA, Cravatt BF. The pharmacological landscape and therapeutic potential of serine hydrolases. Nature Reviews. Drug Discovery. 11: 52-68. PMID 22212679 DOI: 10.1038/Nrd3620  0.405
2012 Seeliger JC, Holsclaw CM, Schelle MW, Botyanszki Z, Gilmore SA, Tully SE, Niederweis M, Cravatt BF, Leary JA, Bertozzi CR. Elucidation and chemical modulation of sulfolipid-1 biosynthesis in Mycobacterium tuberculosis. The Journal of Biological Chemistry. 287: 7990-8000. PMID 22194604 DOI: 10.1074/Jbc.M111.315473  0.357
2012 Chang JW, Moellering RE, Cravatt BF. An activity-based imaging probe for the integral membrane hydrolase KIAA1363. Angewandte Chemie (International Ed. in English). 51: 966-70. PMID 22162147 DOI: 10.1002/Anie.201107236  0.799
2012 Rothmann M, Niessen S, Haushalter RW, Cravatt BF, Burkart MD. Resin-based investigation of acyl carrier protein interaction networks in Escherichia coli. Bioorganic & Medicinal Chemistry. 20: 667-71. PMID 22104437 DOI: 10.1016/J.Bmc.2011.10.053  0.329
2012 Li Y, Martin BR, Cravatt BF, Hofmann SL. DHHC5 protein palmitoylates flotillin-2 and is rapidly degraded on induction of neuronal differentiation in cultured cells. The Journal of Biological Chemistry. 287: 523-30. PMID 22081607 DOI: 10.1074/Jbc.M111.306183  0.59
2012 Martin BR, Wang C, Adibekian A, Tully SE, Cravatt BF. Global profiling of dynamic protein palmitoylation. Nature Methods. 9: 84-9. PMID 22056678 DOI: 10.1038/Nmeth.1769  0.657
2012 Bashashati M, Storr MA, Nikas SP, Wood JT, Godlewski G, Liu J, Ho W, Keenan CM, Zhang H, Alapafuja SO, Cravatt BF, Lutz B, Mackie K, Kunos G, Patel KD, et al. Inhibiting fatty acid amide hydrolase normalizes endotoxin-induced enhanced gastrointestinal motility in mice. British Journal of Pharmacology. 165: 1556-71. PMID 21883147 DOI: 10.1111/J.1476-5381.2011.01644.X  0.326
2012 Kaschani F, Nickel S, Pandey B, Cravatt BF, Kaiser M, van der Hoorn RA. Selective inhibition of plant serine hydrolases by agrochemicals revealed by competitive ABPP. Bioorganic & Medicinal Chemistry. 20: 597-600. PMID 21764588 DOI: 10.1016/J.Bmc.2011.06.040  0.354
2012 Booker L, Kinsey SG, Abdullah RA, Blankman JL, Long JZ, Ezzili C, Boger DL, Cravatt BF, Lichtman AH. The fatty acid amide hydrolase (FAAH) inhibitor PF-3845 acts in the nervous system to reverse LPS-induced tactile allodynia in mice. British Journal of Pharmacology. 165: 2485-96. PMID 21506952 DOI: 10.1111/J.1476-5381.2011.01445.X  0.764
2012 Sticht MA, Long JZ, Rock EM, Limebeer CL, Mechoulam R, Cravatt BF, Parker LA. Inhibition of monoacylglycerol lipase attenuates vomiting in Suncus murinus and 2-arachidonoyl glycerol attenuates nausea in rats. British Journal of Pharmacology. 165: 2425-35. PMID 21470205 DOI: 10.1111/J.1476-5381.2011.01407.X  0.655
2012 Holly SP, Chang JW, Niessen S, Boulaftali Y, Smith MC, Phillips RM, Black JL, Piatt R, Li W, Weyrich AS, Bergmeier W, Cravatt BF, Parise LV. Identification of AADACL1 As a Novel Regulator of Human Platelets Via Chemoproteomics Blood. 120: 381-381. DOI: 10.1182/Blood.V120.21.381.381  0.593
2012 Adibekian A, Martin BR, Wang C, Hsu K, Bachovchin DA, Niessen S, Hoover H, Cravatt BF. Erratum: Corrigendum: Click-generated triazole ureas as ultrapotent in vivo–active serine hydrolase inhibitors Nature Chemical Biology. 8: 318-318. DOI: 10.1038/Nchembio0312-318C  0.764
2012 Blankman JL, Cravatt BF. The endocannabinoid system: From basic research to translational opportunity Acs Chemical Neuroscience. 3: 337-338. DOI: 10.1021/Cn3000444  0.453
2011 Rowland MM, Bostic HE, Gong D, Speers AE, Lucas N, Cho W, Cravatt BF, Best MD. Phosphatidylinositol 3,4,5-trisphosphate activity probes for the labeling and proteomic characterization of protein binding partners. Biochemistry. 50: 11143-61. PMID 22074223 DOI: 10.1021/Bi201636S  0.745
2011 Nomura DK, Morrison BE, Blankman JL, Long JZ, Kinsey SG, Marcondes MC, Ward AM, Hahn YK, Lichtman AH, Conti B, Cravatt BF. Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation. Science (New York, N.Y.). 334: 809-13. PMID 22021672 DOI: 10.1126/Science.1209200  0.802
2011 Long JZ, Cisar JS, Milliken D, Niessen S, Wang C, Trauger SA, Siuzdak G, Cravatt BF. Metabolomics annotates ABHD3 as a physiologic regulator of medium-chain phospholipids. Nature Chemical Biology. 7: 763-5. PMID 21926997 DOI: 10.1038/Nchembio.659  0.732
2011 Tsuboi K, Bachovchin DA, Speers AE, Spicer TP, Fernandez-Vega V, Hodder P, Rosen H, Cravatt BF. Potent and selective inhibitors of glutathione S-transferase omega 1 that impair cancer drug resistance. Journal of the American Chemical Society. 133: 16605-16. PMID 21899313 DOI: 10.1021/Ja2066972  0.76
2011 Nomura DK, Lombardi DP, Chang JW, Niessen S, Ward AM, Long JZ, Hoover HH, Cravatt BF. Monoacylglycerol lipase exerts dual control over endocannabinoid and fatty acid pathways to support prostate cancer. Chemistry & Biology. 18: 846-56. PMID 21802006 DOI: 10.1016/J.Chembiol.2011.05.009  0.779
2011 Kinsey SG, Naidu PS, Cravatt BF, Dudley DT, Lichtman AH. Fatty acid amide hydrolase blockade attenuates the development of collagen-induced arthritis and related thermal hyperalgesia in mice. Pharmacology, Biochemistry, and Behavior. 99: 718-25. PMID 21740924 DOI: 10.1016/J.Pbb.2011.06.022  0.56
2011 Ramesh D, Ross GR, Schlosburg JE, Owens RA, Abdullah RA, Kinsey SG, Long JZ, Nomura DK, Sim-Selley LJ, Cravatt BF, Akbarali HI, Lichtman AH. Blockade of endocannabinoid hydrolytic enzymes attenuates precipitated opioid withdrawal symptoms in mice. The Journal of Pharmacology and Experimental Therapeutics. 339: 173-85. PMID 21719468 DOI: 10.1124/Jpet.111.181370  0.783
2011 Long JZ, Cravatt BF. The metabolic serine hydrolases and their functions in mammalian physiology and disease. Chemical Reviews. 111: 6022-63. PMID 21696217 DOI: 10.1021/Cr200075Y  0.706
2011 Lone AM, Bachovchin DA, Westwood DB, Speers AE, Spicer TP, Fernandez-Vega V, Chase P, Hodder PS, Rosen H, Cravatt BF, Saghatelian A. A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors. Journal of the American Chemical Society. 133: 11665-74. PMID 21692504 DOI: 10.1021/Ja2036095  0.83
2011 Hall CI, Reese ML, Weerapana E, Child MA, Bowyer PW, Albrow VE, Haraldsen JD, Phillips MR, Sandoval ED, Ward GE, Cravatt BF, Boothroyd JC, Bogyo M. Chemical genetic screen identifies Toxoplasma DJ-1 as a regulator of parasite secretion, attachment, and invasion. Proceedings of the National Academy of Sciences of the United States of America. 108: 10568-73. PMID 21670272 DOI: 10.1073/Pnas.1105622108  0.602
2011 Johnson DS, Stiff C, Lazerwith SE, Kesten SR, Fay LK, Morris M, Beidler D, Liimatta MB, Smith SE, Dudley DT, Sadagopan N, Bhattachar SN, Kesten SJ, Nomanbhoy TK, Cravatt BF, et al. Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor. Acs Medicinal Chemistry Letters. 2: 91-96. PMID 21666860 DOI: 10.1021/Ml100190T  0.405
2011 Kinsey SG, Nomura DK, O'Neal ST, Long JZ, Mahadevan A, Cravatt BF, Grider JR, Lichtman AH. Inhibition of monoacylglycerol lipase attenuates nonsteroidal anti-inflammatory drug-induced gastric hemorrhages in mice. The Journal of Pharmacology and Experimental Therapeutics. 338: 795-802. PMID 21659471 DOI: 10.1124/Jpet.110.175778  0.776
2011 Bachovchin DA, Zuhl AM, Speers AE, Wolfe MR, Weerapana E, Brown SJ, Rosen H, Cravatt BF. Discovery and optimization of sulfonyl acrylonitriles as selective, covalent inhibitors of protein phosphatase methylesterase-1. Journal of Medicinal Chemistry. 54: 5229-36. PMID 21639134 DOI: 10.1021/Jm200502U  0.827
2011 Adibekian A, Martin BR, Wang C, Hsu KL, Bachovchin DA, Niessen S, Hoover H, Cravatt BF. Click-generated triazole ureas as ultrapotent in vivo-active serine hydrolase inhibitors. Nature Chemical Biology. 7: 469-78. PMID 21572424 DOI: 10.1038/Nchembio.579  0.811
2011 Straiker A, Wager-Miller J, Hu SS, Blankman JL, Cravatt BF, Mackie K. COX-2 and fatty acid amide hydrolase can regulate the time course of depolarization-induced suppression of excitation. British Journal of Pharmacology. 164: 1672-83. PMID 21564090 DOI: 10.1111/J.1476-5381.2011.01486.X  0.327
2011 Chang JW, Nomura DK, Cravatt BF. A potent and selective inhibitor of KIAA1363/AADACL1 that impairs prostate cancer pathogenesis. Chemistry & Biology. 18: 476-84. PMID 21513884 DOI: 10.1016/J.Chembiol.2011.02.008  0.698
2011 Ahn K, Smith SE, Liimatta MB, Beidler D, Sadagopan N, Dudley DT, Young T, Wren P, Zhang Y, Swaney S, Van Becelaere K, Blankman JL, Nomura DK, Bhattachar SN, Stiff C, ... ... Cravatt BF, et al. Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain. The Journal of Pharmacology and Experimental Therapeutics. 338: 114-24. PMID 21505060 DOI: 10.1124/Jpet.111.180257  0.75
2011 Rossi S, Furlan R, De Chiara V, Muzio L, Musella A, Motta C, Studer V, Cavasinni F, Bernardi G, Martino G, Cravatt BF, Lutz B, Maccarrone M, Centonze D. Cannabinoid CB1 receptors regulate neuronal TNF-α effects in experimental autoimmune encephalomyelitis. Brain, Behavior, and Immunity. 25: 1242-8. PMID 21473912 DOI: 10.1016/J.Bbi.2011.03.017  0.309
2011 Ezzili C, Mileni M, McGlinchey N, Long JZ, Kinsey SG, Hochstatter DG, Stevens RC, Lichtman AH, Cravatt BF, Bilsky EJ, Boger DL. Reversible competitive α-ketoheterocycle inhibitors of fatty acid amide hydrolase containing additional conformational constraints in the acyl side chain: orally active, long-acting analgesics. Journal of Medicinal Chemistry. 54: 2805-22. PMID 21428410 DOI: 10.1021/Jm101597X  0.767
2011 Bachovchin DA, Mohr JT, Speers AE, Wang C, Berlin JM, Spicer TP, Fernandez-Vega V, Chase P, Hodder PS, Schürer SC, Nomura DK, Rosen H, Fu GC, Cravatt BF. Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 108: 6811-6. PMID 21398589 DOI: 10.1073/Pnas.1015248108  0.818
2011 Mukhopadhyay B, Cinar R, Yin S, Liu J, Tam J, Godlewski G, Harvey-White J, Mordi I, Cravatt BF, Lotersztajn S, Gao B, Yuan Q, Schuebel K, Goldman D, Kunos G. Hyperactivation of anandamide synthesis and regulation of cell-cycle progression via cannabinoid type 1 (CB1) receptors in the regenerating liver. Proceedings of the National Academy of Sciences of the United States of America. 108: 6323-8. PMID 21383171 DOI: 10.1073/Pnas.1017689108  0.313
2011 Mileni M, Garfunkle J, Ezzili C, Cravatt BF, Stevens RC, Boger DL. Fluoride-mediated capture of a noncovalent bound state of a reversible covalent enzyme inhibitor: X-ray crystallographic analysis of an exceptionally potent α-ketoheterocycle inhibitor of fatty acid amide hydrolase. Journal of the American Chemical Society. 133: 4092-100. PMID 21355555 DOI: 10.1021/Ja110877Y  0.516
2011 Nicolaou KC, Sanchini S, Sarlah D, Lu G, Wu TR, Nomura DK, Cravatt BF, Cubitt B, de la Torre JC, Hessell AJ, Burton DR. Design, synthesis, and biological evaluation of a biyouyanagin compound library. Proceedings of the National Academy of Sciences of the United States of America. 108: 6715-20. PMID 21245351 DOI: 10.1073/Pnas.1015258108  0.58
2011 Kinsey SG, O'Neal ST, Long JZ, Cravatt BF, Lichtman AH. Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay. Pharmacology, Biochemistry, and Behavior. 98: 21-7. PMID 21145341 DOI: 10.1016/J.Pbb.2010.12.002  0.747
2011 Long JZ, LaCava M, Jin X, Cravatt BF. An anatomical and temporal portrait of physiological substrates for fatty acid amide hydrolase. Journal of Lipid Research. 52: 337-44. PMID 21097653 DOI: 10.1194/Jlr.M012153  0.711
2011 Mukhopadhyay P, Horváth B, Rajesh M, Matsumoto S, Saito K, Bátkai S, Patel V, Tanchian G, Gao RY, Cravatt BF, Haskó G, Pacher P. Fatty acid amide hydrolase is a key regulator of endocannabinoid-induced myocardial tissue injury. Free Radical Biology & Medicine. 50: 179-95. PMID 21070851 DOI: 10.1016/J.Freeradbiomed.2010.11.002  0.343
2011 Meier JL, Patel AD, Niessen S, Meehan M, Kersten R, Yang JY, Rothmann M, Cravatt BF, Dorrestein PC, Burkart MD, Bafna V. Practical 4'-phosphopantetheine active site discovery from proteomic samples. Journal of Proteome Research. 10: 320-9. PMID 21067235 DOI: 10.1021/Pr100953B  0.32
2011 Bowyer PW, Simon GM, Cravatt BF, Bogyo M. Global profiling of proteolysis during rupture of Plasmodium falciparum from the host erythrocyte. Molecular & Cellular Proteomics : McP. 10: M110.001636. PMID 20943600 DOI: 10.1074/Mcp.M110.001636  0.623
2011 Ezzili C, Mileni M, McGlinchey N, Long JZ, Kinsey SG, Hochstatter DG, Stevens RC, Lichtman AH, Cravatt BF, Bilsky EJ, Boger DL. alpha-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Containing Additional Conformational Contraints in the Acyl Side Chain Journal of Medicinal Chemistry. 54: 2805-2822. DOI: 10.2210/Pdb3Oj8/Pdb  0.738
2010 Godlewski G, Alapafuja SO, Bátkai S, Nikas SP, Cinar R, Offertáler L, Osei-Hyiaman D, Liu J, Mukhopadhyay B, Harvey-White J, Tam J, Pacak K, Blankman JL, Cravatt BF, Makriyannis A, et al. Inhibitor of fatty acid amide hydrolase normalizes cardiovascular function in hypertension without adverse metabolic effects. Chemistry & Biology. 17: 1256-66. PMID 21095576 DOI: 10.1016/J.Chembiol.2010.08.013  0.374
2010 Weerapana E, Wang C, Simon GM, Richter F, Khare S, Dillon MB, Bachovchin DA, Mowen K, Baker D, Cravatt BF. Quantitative reactivity profiling predicts functional cysteines in proteomes. Nature. 468: 790-5. PMID 21085121 DOI: 10.1038/Nature09472  0.794
2010 Bachovchin DA, Ji T, Li W, Simon GM, Blankman JL, Adibekian A, Hoover H, Niessen S, Cravatt BF. Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening. Proceedings of the National Academy of Sciences of the United States of America. 107: 20941-6. PMID 21084632 DOI: 10.1073/Pnas.1011663107  0.693
2010 Lichtman AH, Blankman JL, Cravatt BF. Endocannabinoid overload. Molecular Pharmacology. 78: 993-5. PMID 20952498 DOI: 10.1124/Mol.110.069427  0.547
2010 Speers AE, Cravatt BF. Ligands in crystal structures that aid in functional characterization. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 1306-8. PMID 20944226 DOI: 10.1107/S1744309110035748  0.718
2010 Gaultier A, Simon G, Niessen S, Dix M, Takimoto S, Cravatt BF, Gonias SL. LDL receptor-related protein 1 regulates the abundance of diverse cell-signaling proteins in the plasma membrane proteome. Journal of Proteome Research. 9: 6689-95. PMID 20919742 DOI: 10.1021/Pr1008288  0.742
2010 Wurdak H, Zhu S, Min KH, Aimone L, Lairson LL, Watson J, Chopiuk G, Demas J, Charette B, Halder R, Weerapana E, Cravatt BF, Cline HT, Peters EC, Zhang J, et al. A small molecule accelerates neuronal differentiation in the adult rat. Proceedings of the National Academy of Sciences of the United States of America. 107: 16542-7. PMID 20823227 DOI: 10.1073/Pnas.1010300107  0.595
2010 Kopp F, Komatsu T, Nomura DK, Trauger SA, Thomas JR, Siuzdak G, Simon GM, Cravatt BF. The glycerophospho metabolome and its influence on amino acid homeostasis revealed by brain metabolomics of GDE1(-/-) mice. Chemistry & Biology. 17: 831-40. PMID 20797612 DOI: 10.1016/J.Chembiol.2010.06.009  0.739
2010 Knuckley B, Jones JE, Bachovchin DA, Slack J, Causey CP, Brown SJ, Rosen H, Cravatt BF, Thompson PR. A fluopol-ABPP HTS assay to identify PAD inhibitors. Chemical Communications (Cambridge, England). 46: 7175-7. PMID 20740228 DOI: 10.1039/C0Cc02634D  0.375
2010 Schlosburg JE, Blankman JL, Long JZ, Nomura DK, Pan B, Kinsey SG, Nguyen PT, Ramesh D, Booker L, Burston JJ, Thomas EA, Selley DE, Sim-Selley LJ, Liu QS, Lichtman AH, ... Cravatt BF, et al. Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system. Nature Neuroscience. 13: 1113-9. PMID 20729846 DOI: 10.1038/Nn.2616  0.791
2010 Nomura DK, Dix MM, Cravatt BF. Activity-based protein profiling for biochemical pathway discovery in cancer. Nature Reviews. Cancer. 10: 630-8. PMID 20703252 DOI: 10.1038/Nrc2901  0.746
2010 Marrs WR, Blankman JL, Horne EA, Thomazeau A, Lin YH, Coy J, Bodor AL, Muccioli GG, Hu SS, Woodruff G, Fung S, Lafourcade M, Alexander JP, Long JZ, Li W, ... ... Cravatt BF, et al. The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors. Nature Neuroscience. 13: 951-7. PMID 20657592 DOI: 10.1038/Nn.2601  0.652
2010 Hu SS, Arnold A, Hutchens JM, Radicke J, Cravatt BF, Wager-Miller J, Mackie K, Straiker A. Architecture of cannabinoid signaling in mouse retina. The Journal of Comparative Neurology. 518: 3848-66. PMID 20653038 DOI: 10.1002/Cne.22429  0.327
2010 Johnson DS, Weerapana E, Cravatt BF. Strategies for discovering and derisking covalent, irreversible enzyme inhibitors. Future Medicinal Chemistry. 2: 949-64. PMID 20640225 DOI: 10.4155/Fmc.10.21  0.677
2010 Steen PW, Tian S, Tully SE, Cravatt BF, LeMosy EK. Activation of Snake in a serine protease cascade that defines the dorsoventral axis is atypical and pipe-independent in Drosophila embryos. Febs Letters. 584: 3557-60. PMID 20638387 DOI: 10.1016/J.Febslet.2010.07.020  0.303
2010 Buchebner M, Pfeifer T, Rathke N, Chandak PG, Lass A, Schreiber R, Kratzer A, Zimmermann R, Sattler W, Koefeler H, Fröhlich E, Kostner GM, Birner-Gruenberger R, Chiang KP, Haemmerle G, ... ... Cravatt B, et al. Cholesteryl ester hydrolase activity is abolished in HSL-/- macrophages but unchanged in macrophages lacking KIAA1363. Journal of Lipid Research. 51: 2896-908. PMID 20625037 DOI: 10.1194/Jlr.M004259  0.318
2010 Thors L, Burston JJ, Alter BJ, McKinney MK, Cravatt BF, Ross RA, Pertwee RG, Gereau RW, Wiley JL, Fowler CJ. Biochanin A, a naturally occurring inhibitor of fatty acid amide hydrolase. British Journal of Pharmacology. 160: 549-60. PMID 20590565 DOI: 10.1111/J.1476-5381.2010.00716.X  0.786
2010 Kinsey SG, Long JZ, Cravatt BF, Lichtman AH. Fatty acid amide hydrolase and monoacylglycerol lipase inhibitors produce anti-allodynic effects in mice through distinct cannabinoid receptor mechanisms. The Journal of Pain : Official Journal of the American Pain Society. 11: 1420-8. PMID 20554481 DOI: 10.1016/J.Jpain.2010.04.001  0.746
2010 Mileni M, Kamtekar S, Wood DC, Benson TE, Cravatt BF, Stevens RC. Crystal structure of fatty acid amide hydrolase bound to the carbamate inhibitor URB597: discovery of a deacylating water molecule and insight into enzyme inactivation. Journal of Molecular Biology. 400: 743-54. PMID 20493882 DOI: 10.1016/J.Jmb.2010.05.034  0.383
2010 Freigang S, Zadorozhny V, McKinney MK, Krebs P, Herro R, Pawlak J, Kain L, Schrantz N, Masuda K, Liu Y, Savage PB, Bendelac A, Cravatt BF, Teyton L. Fatty acid amide hydrolase shapes NKT cell responses by influencing the serum transport of lipid antigen in mice. The Journal of Clinical Investigation. 120: 1873-84. PMID 20484813 DOI: 10.1172/Jci40451  0.775
2010 Rossi S, De Chiara V, Musella A, Sacchetti L, Cantarella C, Castelli M, Cavasinni F, Motta C, Studer V, Bernardi G, Cravatt BF, Maccarrone M, Usiello A, Centonze D. Preservation of striatal cannabinoid CB1 receptor function correlates with the antianxiety effects of fatty acid amide hydrolase inhibition. Molecular Pharmacology. 78: 260-8. PMID 20424126 DOI: 10.1124/Mol.110.064196  0.357
2010 Simon GM, Cravatt BF. Characterization of mice lacking candidate N-acyl ethanolamine biosynthetic enzymes provides evidence for multiple pathways that contribute to endocannabinoid production in vivo. Molecular Biosystems. 6: 1411-8. PMID 20393650 DOI: 10.1039/C000237B  0.659
2010 Naidu PS, Kinsey SG, Guo TL, Cravatt BF, Lichtman AH. Regulation of inflammatory pain by inhibition of fatty acid amide hydrolase. The Journal of Pharmacology and Experimental Therapeutics. 334: 182-90. PMID 20375198 DOI: 10.1124/Jpet.109.164806  0.545
2010 Falenski KW, Thorpe AJ, Schlosburg JE, Cravatt BF, Abdullah RA, Smith TH, Selley DE, Lichtman AH, Sim-Selley LJ. FAAH-/- mice display differential tolerance, dependence, and cannabinoid receptor adaptation after delta 9-tetrahydrocannabinol and anandamide administration. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 35: 1775-87. PMID 20357755 DOI: 10.1038/Npp.2010.44  0.529
2010 Bachovchin DA, Wolfe MR, Masuda K, Brown SJ, Spicer TP, Fernandez-Vega V, Chase P, Hodder PS, Rosen H, Cravatt BF. Oxime esters as selective, covalent inhibitors of the serine hydrolase retinoblastoma-binding protein 9 (RBBP9). Bioorganic & Medicinal Chemistry Letters. 20: 2254-8. PMID 20207142 DOI: 10.1016/J.Bmcl.2010.02.011  0.436
2010 Tully SE, Cravatt BF. Activity-based probes that target functional subclasses of phospholipases in proteomes. Journal of the American Chemical Society. 132: 3264-5. PMID 20178358 DOI: 10.1021/Ja1000505  0.448
2010 Ramya TN, Weerapana E, Liao L, Zeng Y, Tateno H, Liao L, Yates JR, Cravatt BF, Paulson JC. In situ trans ligands of CD22 identified by glycan-protein photocross-linking-enabled proteomics. Molecular & Cellular Proteomics : McP. 9: 1339-51. PMID 20172905 DOI: 10.1074/Mcp.M900461-Mcp200  0.57
2010 Simon GM, Cravatt BF. Activity-based proteomics of enzyme superfamilies: serine hydrolases as a case study. The Journal of Biological Chemistry. 285: 11051-5. PMID 20147750 DOI: 10.1074/Jbc.R109.097600  0.688
2010 Cravatt BF, Gottesfeld JM. Chemical biology meets biological chemistry minireview series. The Journal of Biological Chemistry. 285: 11031-2. PMID 20147295 DOI: 10.1074/Jbc.R110.113126  0.316
2010 Long JZ, Jin X, Adibekian A, Li W, Cravatt BF. Characterization of tunable piperidine and piperazine carbamates as inhibitors of endocannabinoid hydrolases. Journal of Medicinal Chemistry. 53: 1830-42. PMID 20099888 DOI: 10.1021/Jm9016976  0.733
2010 Sipe JC, Scott TM, Murray S, Harismendy O, Simon GM, Cravatt BF, Waalen J. Biomarkers of endocannabinoid system activation in severe obesity. Plos One. 5: e8792. PMID 20098695 DOI: 10.1371/Journal.Pone.0008792  0.594
2010 Shields DJ, Niessen S, Murphy EA, Mielgo A, Desgrosellier JS, Lau SK, Barnes LA, Lesperance J, Bouvet M, Tarin D, Cravatt BF, Cheresh DA. RBBP9: a tumor-associated serine hydrolase activity required for pancreatic neoplasia. Proceedings of the National Academy of Sciences of the United States of America. 107: 2189-94. PMID 20080647 DOI: 10.1073/Pnas.0911646107  0.33
2010 Nomura DK, Long JZ, Niessen S, Hoover HS, Ng SW, Cravatt BF. Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis. Cell. 140: 49-61. PMID 20079333 DOI: 10.1016/J.Cell.2009.11.027  0.747
2010 Mileni M, Garfunkle J, Ezzili C, Kimball FS, Cravatt BF, Stevens RC, Boger DL. X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase. Journal of Medicinal Chemistry. 53: 230-40. PMID 19924997 DOI: 10.1021/Jm9012196  0.502
2010 Lombardi DP, Nomura DK, Cravatt BF. Proteomic and metabolomic analysis of inhibition of monoacylglycerol lipase (MAGL) in human prostate cancer. Journal of Clinical Oncology. 28: e15035-e15035. DOI: 10.1200/Jco.2010.28.15_Suppl.E15035  0.57
2010 Kinsey S, Long J, Cravatt B, Lichtman A. Inhibiting endocannabinoid catabolic enzymes attenuates neuropathic pain via distinct cannabinoid receptor mediated mechanisms of action Brain, Behavior, and Immunity. 24: S6. DOI: 10.1016/J.Bbi.2010.07.019  0.721
2010 PATTERSON JE, OLLMANN IR, CRAVATT BF, BOGER DL, WONG C, LERNER RA. ChemInform Abstract: Inhibition of Oleamide Hydrolase Catalyzed Hydrolysis of the Endogenous Sleep-Inducing Lipid cis-9-Octadecenamide. Cheminform. 27: no-no. DOI: 10.1002/chin.199640217  0.506
2010 BOGER DL, LERNER RA, CRAVATT BF. ChemInform Abstract: Synthesis of a Functionalized Rigid Bicyclo(2.2.1)heptane: A Useful Hapten for Eliciting Catalytic Antibodies. Cheminform. 26: no-no. DOI: 10.1002/chin.199511111  0.485
2009 Speers AE, Cravatt BF. Activity-Based Protein Profiling (ABPP) and Click Chemistry (CC)-ABPP by MudPIT Mass Spectrometry. Current Protocols in Chemical Biology. 1: 29-41. PMID 21701697 DOI: 10.1002/9780470559277.Ch090138  0.759
2009 Ahn K, Johnson DS, Cravatt BF. Fatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disorders. Expert Opinion On Drug Discovery. 4: 763-784. PMID 20544003 DOI: 10.1517/17460440903018857  0.453
2009 Long JZ, Nomura DK, Vann RE, Walentiny DM, Booker L, Jin X, Burston JJ, Sim-Selley LJ, Lichtman AH, Wiley JL, Cravatt BF. Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. Proceedings of the National Academy of Sciences of the United States of America. 106: 20270-5. PMID 19918051 DOI: 10.1073/Pnas.0909411106  0.817
2009 Meier JL, Niessen S, Hoover HS, Foley TL, Cravatt BF, Burkart MD. An orthogonal active site identification system (OASIS) for proteomic profiling of natural product biosynthesis. Acs Chemical Biology. 4: 948-57. PMID 19785476 DOI: 10.1021/Cb9002128  0.401
2009 Straiker A, Hu SS, Long JZ, Arnold A, Wager-Miller J, Cravatt BF, Mackie K. Monoacylglycerol lipase limits the duration of endocannabinoid-mediated depolarization-induced suppression of excitation in autaptic hippocampal neurons. Molecular Pharmacology. 76: 1220-7. PMID 19767452 DOI: 10.1124/Mol.109.059030  0.661
2009 Mileni M, Garfunkle J, DeMartino JK, Cravatt BF, Boger DL, Stevens RC. Binding and inactivation mechanism of a humanized fatty acid amide hydrolase by alpha-ketoheterocycle inhibitors revealed from cocrystal structures. Journal of the American Chemical Society. 131: 10497-506. PMID 19722626 DOI: 10.1021/Ja902694N  0.532
2009 Sabidó E, Tarragó T, Niessen S, Cravatt BF, Giralt E. Activity-based probes for monitoring postproline protease activity. Chembiochem : a European Journal of Chemical Biology. 10: 2361-6. PMID 19688784 DOI: 10.1002/Cbic.200900244  0.391
2009 Pan B, Wang W, Long JZ, Sun D, Hillard CJ, Cravatt BF, Liu QS. Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances retrograde endocannabinoid signaling. The Journal of Pharmacology and Experimental Therapeutics. 331: 591-7. PMID 19666749 DOI: 10.1124/Jpet.109.158162  0.675
2009 Long JZ, Nomura DK, Cravatt BF. Characterization of monoacylglycerol lipase inhibition reveals differences in central and peripheral endocannabinoid metabolism. Chemistry & Biology. 16: 744-53. PMID 19635411 DOI: 10.1016/J.Chembiol.2009.05.009  0.771
2009 Wright AT, Song JD, Cravatt BF. A suite of activity-based probes for human cytochrome P450 enzymes. Journal of the American Chemical Society. 131: 10692-700. PMID 19583257 DOI: 10.1021/Ja9037609  0.666
2009 Hu SS, Bradshaw HB, Benton VM, Chen JS, Huang SM, Minassi A, Bisogno T, Masuda K, Tan B, Roskoski R, Cravatt BF, Di Marzo V, Walker JM. The biosynthesis of N-arachidonoyl dopamine (NADA), a putative endocannabinoid and endovanilloid, via conjugation of arachidonic acid with dopamine. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 81: 291-301. PMID 19570666 DOI: 10.1016/J.Plefa.2009.05.026  0.356
2009 Kinsey SG, Long JZ, O'Neal ST, Abdullah RA, Poklis JL, Boger DL, Cravatt BF, Lichtman AH. Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain. The Journal of Pharmacology and Experimental Therapeutics. 330: 902-10. PMID 19502530 DOI: 10.1124/Jpet.109.155465  0.766
2009 Bradshaw HB, Rimmerman N, Hu SS, Benton VM, Stuart JM, Masuda K, Cravatt BF, O'Dell DK, Walker JM. The endocannabinoid anandamide is a precursor for the signaling lipid N-arachidonoyl glycine by two distinct pathways. Bmc Biochemistry. 10: 14. PMID 19460156 DOI: 10.1186/1471-2091-10-14  0.363
2009 Schlosburg JE, Carlson BL, Ramesh D, Abdullah RA, Long JZ, Cravatt BF, Lichtman AH. Inhibitors of endocannabinoid-metabolizing enzymes reduce precipitated withdrawal responses in THC-dependent mice. The Aaps Journal. 11: 342-52. PMID 19430909 DOI: 10.1208/S12248-009-9110-7  0.747
2009 Simon GM, Dix MM, Cravatt BF. Comparative assessment of large-scale proteomic studies of apoptotic proteolysis. Acs Chemical Biology. 4: 401-8. PMID 19415908 DOI: 10.1021/Cb900082Q  0.732
2009 Ahn K, Johnson DS, Mileni M, Beidler D, Long JZ, McKinney MK, Weerapana E, Sadagopan N, Liimatta M, Smith SE, Lazerwith S, Stiff C, Kamtekar S, Bhattacharya K, Zhang Y, ... ... Cravatt BF, et al. Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain. Chemistry & Biology. 16: 411-20. PMID 19389627 DOI: 10.1016/J.Chembiol.2009.02.013  0.819
2009 Johnson DS, Ahn K, Kesten S, Lazerwith SE, Song Y, Morris M, Fay L, Gregory T, Stiff C, Dunbar JB, Liimatta M, Beidler D, Smith S, Nomanbhoy TK, Cravatt BF. Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH). Bioorganic & Medicinal Chemistry Letters. 19: 2865-9. PMID 19386497 DOI: 10.1016/J.Bmcl.2009.03.080  0.429
2009 Bachovchin DA, Brown SJ, Rosen H, Cravatt BF. Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes. Nature Biotechnology. 27: 387-94. PMID 19329999 DOI: 10.1038/Nbt.1531  0.435
2009 Lever IJ, Robinson M, Cibelli M, Paule C, Santha P, Yee L, Hunt SP, Cravatt BF, Elphick MR, Nagy I, Rice AS. Localization of the endocannabinoid-degrading enzyme fatty acid amide hydrolase in rat dorsal root ganglion cells and its regulation after peripheral nerve injury. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 3766-80. PMID 19321773 DOI: 10.1523/Jneurosci.4071-08.2009  0.585
2009 Schlosburg JE, Boger DL, Cravatt BF, Lichtman AH. Endocannabinoid modulation of scratching response in an acute allergenic model: a new prospective neural therapeutic target for pruritus. The Journal of Pharmacology and Experimental Therapeutics. 329: 314-23. PMID 19168707 DOI: 10.1124/Jpet.108.150136  0.627
2009 Martin BR, Cravatt BF. Large-scale profiling of protein palmitoylation in mammalian cells. Nature Methods. 6: 135-8. PMID 19137006 DOI: 10.1038/Nmeth.1293  0.581
2009 Kaschani F, Gu C, Niessen S, Hoover H, Cravatt BF, van der Hoorn RA. Diversity of serine hydrolase activities of unchallenged and botrytis-infected Arabidopsis thaliana. Molecular & Cellular Proteomics : McP. 8: 1082-93. PMID 19136719 DOI: 10.1074/Mcp.M800494-Mcp200  0.4
2009 Naidu PS, Booker L, Cravatt BF, Lichtman AH. Synergy between enzyme inhibitors of fatty acid amide hydrolase and cyclooxygenase in visceral nociception. The Journal of Pharmacology and Experimental Therapeutics. 329: 48-56. PMID 19118134 DOI: 10.1124/Jpet.108.143487  0.568
2009 Long JZ, Li W, Booker L, Burston JJ, Kinsey SG, Schlosburg JE, Pavón FJ, Serrano AM, Selley DE, Parsons LH, Lichtman AH, Cravatt BF. Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects. Nature Chemical Biology. 5: 37-44. PMID 19029917 DOI: 10.1038/Nchembio.129  0.738
2009 Nakai R, Salisbury CM, Rosen H, Cravatt BF. Ranking the selectivity of PubChem screening hits by activity-based protein profiling: MMP13 as a case study. Bioorganic & Medicinal Chemistry. 17: 1101-8. PMID 18364257 DOI: 10.1016/J.Bmc.2008.03.018  0.766
2008 Barglow KT, Saikatendu KS, Bracey MH, Huey R, Morris GM, Olson AJ, Stevens RC, Cravatt BF. Functional proteomic and structural insights into molecular recognition in the nitrilase family enzymes. Biochemistry. 47: 13514-23. PMID 19053248 DOI: 10.1021/Bi801786Y  0.82
2008 Simon GM, Cravatt BF. Challenges for the 'chemical-systems' biologist. Nature Chemical Biology. 4: 639-42. PMID 18936742 DOI: 10.1038/Nchembio1108-639  0.594
2008 Mileni M, Johnson DS, Wang Z, Everdeen DS, Liimatta M, Pabst B, Bhattacharya K, Nugent RA, Kamtekar S, Cravatt BF, Ahn K, Stevens RC. Structure-guided inhibitor design for human FAAH by interspecies active site conversion. Proceedings of the National Academy of Sciences of the United States of America. 105: 12820-4. PMID 18753625 DOI: 10.1073/Pnas.0806121105  0.416
2008 Dix MM, Simon GM, Cravatt BF. Global mapping of the topography and magnitude of proteolytic events in apoptosis. Cell. 134: 679-91. PMID 18724940 DOI: 10.1016/J.Cell.2008.06.038  0.752
2008 Hoover HS, Blankman JL, Niessen S, Cravatt BF. Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling. Bioorganic & Medicinal Chemistry Letters. 18: 5838-41. PMID 18657971 DOI: 10.1016/J.Bmcl.2008.06.091  0.373
2008 Slaymaker IM, Bracey M, Mileni M, Garfunkle J, Cravatt BF, Boger DL, Stevens RC. Correlation of inhibitor effects on enzyme activity and thermal stability for the integral membrane protein fatty acid amide hydrolase. Bioorganic & Medicinal Chemistry Letters. 18: 5847-50. PMID 18644727 DOI: 10.1016/J.Bmcl.2008.06.086  0.498
2008 DeMartino JK, Garfunkle J, Hochstatter DG, Cravatt BF, Boger DL. Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hydrolase. Bioorganic & Medicinal Chemistry Letters. 18: 5842-6. PMID 18639454 DOI: 10.1016/J.Bmcl.2008.06.084  0.503
2008 Ortega-Gutiérrez S, Leung D, Ficarro S, Peters EC, Cravatt BF. Targeted disruption of the PME-1 gene causes loss of demethylated PP2A and perinatal lethality in mice. Plos One. 3: e2486. PMID 18596935 DOI: 10.1371/Journal.Pone.0002486  0.368
2008 Weerapana E, Simon GM, Cravatt BF. Disparate proteome reactivity profiles of carbon electrophiles. Nature Chemical Biology. 4: 405-7. PMID 18488014 DOI: 10.1038/Nchembio.91  0.754
2008 Wang P, Shim E, Cravatt B, Jacobsen R, Schoeniger J, Kim AC, Paetzel M, Dalbey RE. Escherichia coli signal peptide peptidase A is a serine-lysine protease with a lysine recruited to the nonconserved amino-terminal domain in the S49 protease family. Biochemistry. 47: 6361-9. PMID 18476724 DOI: 10.1021/Bi800657P  0.31
2008 Nomura DK, Blankman JL, Simon GM, Fujioka K, Issa RS, Ward AM, Cravatt BF, Casida JE. Activation of the endocannabinoid system by organophosphorus nerve agents. Nature Chemical Biology. 4: 373-8. PMID 18438404 DOI: 10.1038/Nchembio.86  0.781
2008 Ahn K, McKinney MK, Cravatt BF. Enzymatic pathways that regulate endocannabinoid signaling in the nervous system. Chemical Reviews. 108: 1687-707. PMID 18429637 DOI: 10.1021/Cr0782067  0.783
2008 Rimmerman N, Bradshaw HB, Hughes HV, Chen JS, Hu SS, McHugh D, Vefring E, Jahnsen JA, Thompson EL, Masuda K, Cravatt BF, Burstein S, Vasko MR, Prieto AL, O'Dell DK, et al. N-palmitoyl glycine, a novel endogenous lipid that acts as a modulator of calcium influx and nitric oxide production in sensory neurons. Molecular Pharmacology. 74: 213-24. PMID 18424551 DOI: 10.1124/Mol.108.045997  0.351
2008 Hegde VL, Hegde S, Cravatt BF, Hofseth LJ, Nagarkatti M, Nagarkatti PS. Attenuation of experimental autoimmune hepatitis by exogenous and endogenous cannabinoids: involvement of regulatory T cells. Molecular Pharmacology. 74: 20-33. PMID 18388242 DOI: 10.1124/Mol.108.047035  0.313
2008 Gaultier A, Arandjelovic S, Niessen S, Overton CD, Linton MF, Fazio S, Campana WM, Cravatt BF, Gonias SL. Regulation of tumor necrosis factor receptor-1 and the IKK-NF-kappaB pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptor. Blood. 111: 5316-25. PMID 18369152 DOI: 10.1182/Blood-2007-12-127613  0.337
2008 Cravatt BF, Wright AT, Kozarich JW. Activity-based protein profiling: from enzyme chemistry to proteomic chemistry. Annual Review of Biochemistry. 77: 383-414. PMID 18366325 DOI: 10.1146/Annurev.Biochem.75.101304.124125  0.68
2008 Turman MV, Kingsley PJ, Rouzer CA, Cravatt BF, Marnett LJ. Oxidative metabolism of a fatty acid amide hydrolase-regulated lipid, arachidonoyltaurine. Biochemistry. 47: 3917-25. PMID 18311922 DOI: 10.1021/Bi702530Z  0.345
2008 Nyilas R, Dudok B, Urbán GM, Mackie K, Watanabe M, Cravatt BF, Freund TF, Katona I. Enzymatic machinery for endocannabinoid biosynthesis associated with calcium stores in glutamatergic axon terminals. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 1058-63. PMID 18234884 DOI: 10.1523/Jneurosci.5102-07.2008  0.324
2008 Simon GM, Cravatt BF. Anandamide biosynthesis catalyzed by the phosphodiesterase GDE1 and detection of glycerophospho-N-acyl ethanolamine precursors in mouse brain. The Journal of Biological Chemistry. 283: 9341-9. PMID 18227059 DOI: 10.1074/Jbc.M707807200  0.641
2008 Salisbury CM, Cravatt BF. Optimization of activity-based probes for proteomic profiling of histone deacetylase complexes. Journal of the American Chemical Society. 130: 2184-94. PMID 18217751 DOI: 10.1021/Ja074138U  0.78
2008 Maccarrone M, Rossi S, Bari M, De Chiara V, Fezza F, Musella A, Gasperi V, Prosperetti C, Bernardi G, Finazzi-Agrò A, Cravatt BF, Centonze D. Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum. Nature Neuroscience. 11: 152-9. PMID 18204441 DOI: 10.1038/Nn2042  0.314
2008 Nomura DK, Fujioka K, Issa RS, Ward AM, Cravatt BF, Casida JE. Dual roles of brain serine hydrolase KIAA1363 in ether lipid metabolism and organophosphate detoxification. Toxicology and Applied Pharmacology. 228: 42-8. PMID 18164358 DOI: 10.1016/J.Taap.2007.11.021  0.674
2008 Egertová M, Simon GM, Cravatt BF, Elphick MR. Localization of N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) expression in mouse brain: A new perspective on N-acylethanolamines as neural signaling molecules. The Journal of Comparative Neurology. 506: 604-15. PMID 18067139 DOI: 10.1002/Cne.21568  0.729
2008 Wise LE, Cannavacciulo R, Cravatt BF, Martin BF, Lichtman AH. Evaluation of fatty acid amides in the carrageenan-induced paw edema model. Neuropharmacology. 54: 181-8. PMID 17675189 DOI: 10.1016/J.Neuropharm.2007.06.003  0.535
2008 Jessani N, Cravatt BF. Reverse Chemical Genetics Revisited: Chemical Strategies for Activity-based Proteomics Chemical Biology: From Small Molecules to Systems Biology and Drug Design, Volume 1-3. 1: 403-426. DOI: 10.1002/9783527619375.ch7c  0.703
2007 Blankman JL, Simon GM, Cravatt BF. A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol. Chemistry & Biology. 14: 1347-56. PMID 18096503 DOI: 10.1016/J.Chembiol.2007.11.006  0.665
2007 Cravatt BF, Simon GM, Yates JR. The biological impact of mass-spectrometry-based proteomics. Nature. 450: 991-1000. PMID 18075578 DOI: 10.1038/Nature06525  0.619
2007 Chamero P, Marton TF, Logan DW, Flanagan K, Cruz JR, Saghatelian A, Cravatt BF, Stowers L. Identification of protein pheromones that promote aggressive behaviour. Nature. 450: 899-902. PMID 18064011 DOI: 10.1038/Nature05997  0.572
2007 Carlson EE, Cravatt BF. Enrichment tags for enhanced-resolution profiling of the polar metabolome. Journal of the American Chemical Society. 129: 15780-2. PMID 18052286 DOI: 10.1021/Ja0779506  0.59
2007 Ahn K, Johnson DS, Fitzgerald LR, Liimatta M, Arendse A, Stevenson T, Lund ET, Nugent RA, Nomanbhoy TK, Alexander JP, Cravatt BF. Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity. Biochemistry. 46: 13019-30. PMID 17949010 DOI: 10.1021/Bi701378G  0.468
2007 List K, Currie B, Scharschmidt TC, Szabo R, Shireman J, Molinolo A, Cravatt BF, Segre J, Bugge TH. Autosomal ichthyosis with hypotrichosis syndrome displays low matriptase proteolytic activity and is phenocopied in ST14 hypomorphic mice. The Journal of Biological Chemistry. 282: 36714-23. PMID 17940283 DOI: 10.1074/Jbc.M705521200  0.329
2007 Barglow KT, Cravatt BF. Activity-based protein profiling for the functional annotation of enzymes. Nature Methods. 4: 822-7. PMID 17901872 DOI: 10.1038/Nmeth1092  0.821
2007 Wright AT, Cravatt BF. Chemical proteomic probes for profiling cytochrome p450 activities and drug interactions in vivo. Chemistry & Biology. 14: 1043-51. PMID 17884636 DOI: 10.1016/J.Chembiol.2007.08.008  0.654
2007 Wan Y, Saghatelian A, Chong LW, Zhang CL, Cravatt BF, Evans RM. Maternal PPAR gamma protects nursing neonates by suppressing the production of inflammatory milk. Genes & Development. 21: 1895-908. PMID 17652179 DOI: 10.1101/Gad.1567207  0.557
2007 Vila A, Rosengarth A, Piomelli D, Cravatt B, Marnett LJ. Hydrolysis of prostaglandin glycerol esters by the endocannabinoid-hydrolyzing enzymes, monoacylglycerol lipase and fatty acid amide hydrolase. Biochemistry. 46: 9578-85. PMID 17649977 DOI: 10.1021/Bi7005898  0.391
2007 Li W, Blankman JL, Cravatt BF. A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases. Journal of the American Chemical Society. 129: 9594-5. PMID 17629278 DOI: 10.1021/Ja073650C  0.445
2007 Everley PA, Gartner CA, Haas W, Saghatelian A, Elias JE, Cravatt BF, Zetter BR, Gygi SP. Assessing enzyme activities using stable isotope labeling and mass spectrometry. Molecular & Cellular Proteomics : McP. 6: 1771-7. PMID 17627935 DOI: 10.1074/Mcp.M700057-Mcp200  0.618
2007 Evans MJ, Morris GM, Wu J, Olson AJ, Sorensen EJ, Cravatt BF. Mechanistic and structural requirements for active site labeling of phosphoglycerate mutase by spiroepoxides. Molecular Biosystems. 3: 495-506. PMID 17579775 DOI: 10.1039/B705113A  0.397
2007 Hardouin C, Kelso MJ, Romero FA, Rayl TJ, Leung D, Hwang I, Cravatt BF, Boger DL. Structure-activity relationships of alpha-ketooxazole inhibitors of fatty acid amide hydrolase. Journal of Medicinal Chemistry. 50: 3359-68. PMID 17559203 DOI: 10.1021/Jm061414R  0.502
2007 Weerapana E, Speers AE, Cravatt BF. Tandem orthogonal proteolysis-activity-based protein profiling (TOP-ABPP)--a general method for mapping sites of probe modification in proteomes. Nature Protocols. 2: 1414-25. PMID 17545978 DOI: 10.1038/Nprot.2007.194  0.813
2007 Hanson SR, Hsu TL, Weerapana E, Kishikawa K, Simon GM, Cravatt BF, Wong CH. Tailored glycoproteomics and glycan site mapping using saccharide-selective bioorthogonal probes. Journal of the American Chemical Society. 129: 7266-7. PMID 17506567 DOI: 10.1021/Ja0724083  0.744
2007 Bátkai S, Rajesh M, Mukhopadhyay P, Haskó G, Liaudet L, Cravatt BF, Csiszár A, Ungvári Z, Pacher P. Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase. American Journal of Physiology. Heart and Circulatory Physiology. 293: H909-18. PMID 17434980 DOI: 10.1152/Ajpheart.00373.2007  0.327
2007 Carlson EE, Cravatt BF. Chemoselective probes for metabolite enrichment and profiling. Nature Methods. 4: 429-35. PMID 17417646 DOI: 10.1038/Nmeth1038  0.611
2007 Romero FA, Du W, Hwang I, Rayl TJ, Kimball FS, Leung D, Hoover HS, Apodaca RL, Breitenbucher JG, Cravatt BF, Boger DL. Potent and selective alpha-ketoheterocycle-based inhibitors of the anandamide and oleamide catabolizing enzyme, fatty acid amide hydrolase. Journal of Medicinal Chemistry. 50: 1058-68. PMID 17279740 DOI: 10.1021/Jm0611509  0.511
2007 Naidu PS, Varvel SA, Ahn K, Cravatt BF, Martin BR, Lichtman AH. Evaluation of fatty acid amide hydrolase inhibition in murine models of emotionality. Psychopharmacology. 192: 61-70. PMID 17279376 DOI: 10.1007/S00213-006-0689-4  0.659
2007 Macpherson LJ, Dubin AE, Evans MJ, Marr F, Schultz PG, Cravatt BF, Patapoutian A. Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. Nature. 445: 541-5. PMID 17237762 DOI: 10.1038/Nature05544  0.322
2007 Salisbury CM, Cravatt BF. Activity-based probes for proteomic profiling of histone deacetylase complexes. Proceedings of the National Academy of Sciences of the United States of America. 104: 1171-6. PMID 17227860 DOI: 10.1073/Pnas.0608659104  0.778
2007 Wise LE, Shelton CC, Cravatt BF, Martin BR, Lichtman AH. Assessment of anandamide's pharmacological effects in mice deficient of both fatty acid amide hydrolase and cannabinoid CB1 receptors. European Journal of Pharmacology. 557: 44-8. PMID 17217945 DOI: 10.1016/J.Ejphar.2006.11.002  0.652
2007 Mei G, Di Venere A, Gasperi V, Nicolai E, Masuda KR, Finazzi-Agrò A, Cravatt BF, Maccarrone M. Closing the gate to the active site: effect of the inhibitor methoxyarachidonyl fluorophosphonate on the conformation and membrane binding of fatty acid amide hydrolase. The Journal of Biological Chemistry. 282: 3829-36. PMID 17158103 DOI: 10.1074/Jbc.M605653200  0.372
2007 Fu J, Astarita G, Gaetani S, Kim J, Cravatt BF, Mackie K, Piomelli D. Food intake regulates oleoylethanolamide formation and degradation in the proximal small intestine. The Journal of Biological Chemistry. 282: 1518-28. PMID 17121838 DOI: 10.1074/Jbc.M607809200  0.335
2007 Varvel SA, Wise LE, Niyuhire F, Cravatt BF, Lichtman AH. Inhibition of fatty-acid amide hydrolase accelerates acquisition and extinction rates in a spatial memory task. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 32: 1032-41. PMID 17047668 DOI: 10.1038/Sj.Npp.1301224  0.549
2007 Salisbury CM, Cravatt BF. Click chemistry-led advances in high content functional proteomics Qsar and Combinatorial Science. 26: 1229-1238. DOI: 10.1002/Qsar.200740090  0.776
2006 Chiang KP, Niessen S, Saghatelian A, Cravatt BF. An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling. Chemistry & Biology. 13: 1041-50. PMID 17052608 DOI: 10.1016/J.Chembiol.2006.08.008  0.634
2006 Barglow KT, Cravatt BF. Substrate mimicry in an activity-based probe that targets the nitrilase family of enzymes. Angewandte Chemie (International Ed. in English). 45: 7408-11. PMID 17036295 DOI: 10.1002/Anie.200603187  0.8
2006 Wei BQ, Mikkelsen TS, McKinney MK, Lander ES, Cravatt BF. A second fatty acid amide hydrolase with variable distribution among placental mammals. The Journal of Biological Chemistry. 281: 36569-78. PMID 17015445 DOI: 10.1074/Jbc.M606646200  0.794
2006 Mulder AM, Cravatt BF. Endocannabinoid metabolism in the absence of fatty acid amide hydrolase (FAAH): discovery of phosphorylcholine derivatives of N-acyl ethanolamines. Biochemistry. 45: 11267-77. PMID 16981687 DOI: 10.1021/Bi061122S  0.375
2006 Nomura DK, Durkin KA, Chiang KP, Quistad GB, Cravatt BF, Casida JE. Serine hydrolase KIAA1363: toxicological and structural features with emphasis on organophosphate interactions. Chemical Research in Toxicology. 19: 1142-50. PMID 16978018 DOI: 10.1021/Tx060117M  0.688
2006 Evans MJ, Cravatt BF. Mechanism-based profiling of enzyme families. Chemical Reviews. 106: 3279-301. PMID 16895328 DOI: 10.1021/Cr050288G  0.314
2006 Alexander JP, Cravatt BF. The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases. Journal of the American Chemical Society. 128: 9699-704. PMID 16866524 DOI: 10.1021/Ja062999H  0.475
2006 McKinney MK, Cravatt BF. Structure-based design of a FAAH variant that discriminates between the N-acyl ethanolamine and taurine families of signaling lipids. Biochemistry. 45: 9016-22. PMID 16866346 DOI: 10.1021/Bi0608010  0.791
2006 Saghatelian A, McKinney MK, Bandell M, Patapoutian A, Cravatt BF. A FAAH-regulated class of N-acyl taurines that activates TRP ion channels. Biochemistry. 45: 9007-15. PMID 16866345 DOI: 10.1021/Bi0608008  0.809
2006 Simon GM, Cravatt BF. Endocannabinoid biosynthesis proceeding through glycerophospho-N-acyl ethanolamine and a role for alpha/beta-hydrolase 4 in this pathway. The Journal of Biological Chemistry. 281: 26465-72. PMID 16818490 DOI: 10.1074/Jbc.M604660200  0.663
2006 Sieber SA, Cravatt BF. Analytical platforms for activity-based protein profiling--exploiting the versatility of chemistry for functional proteomics. Chemical Communications (Cambridge, England). 2311-9. PMID 16733565 DOI: 10.1039/B600653C  0.636
2006 Madsen MA, Deryugina EI, Niessen S, Cravatt BF, Quigley JP. Activity-based protein profiling implicates urokinase activation as a key step in human fibrosarcoma intravasation. The Journal of Biological Chemistry. 281: 15997-6005. PMID 16611636 DOI: 10.1074/Jbc.M601223200  0.311
2006 Leung D, Saghatelian A, Simon GM, Cravatt BF. Inactivation of N-acyl phosphatidylethanolamine phospholipase D reveals multiple mechanisms for the biosynthesis of endocannabinoids. Biochemistry. 45: 4720-6. PMID 16605240 DOI: 10.1021/Bi060163L  0.749
2006 Sieber SA, Niessen S, Hoover HS, Cravatt BF. Proteomic profiling of metalloprotease activities with cocktails of active-site probes. Nature Chemical Biology. 2: 274-81. PMID 16565715 DOI: 10.1038/Nchembio781  0.646
2006 Balakrishnan A, Patel B, Sieber SA, Chen D, Pachikara N, Zhong G, Cravatt BF, Fan H. Metalloprotease inhibitors GM6001 and TAPI-0 inhibit the obligate intracellular human pathogen Chlamydia trachomatis by targeting peptide deformylase of the bacterium. The Journal of Biological Chemistry. 281: 16691-9. PMID 16565079 DOI: 10.1074/Jbc.M513648200  0.626
2006 Aguado T, Palazuelos J, Monory K, Stella N, Cravatt B, Lutz B, Marsicano G, Kokaia Z, Guzmán M, Galve-Roperh I. The endocannabinoid system promotes astroglial differentiation by acting on neural progenitor cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 1551-61. PMID 16452678 DOI: 10.1523/Jneurosci.3101-05.2006  0.317
2006 Varvel SA, Cravatt BF, Engram AE, Lichtman AH. Fatty acid amide hydrolase (-/-) mice exhibit an increased sensitivity to the disruptive effects of anandamide or oleamide in a working memory water maze task. The Journal of Pharmacology and Experimental Therapeutics. 317: 251-7. PMID 16352706 DOI: 10.1124/Jpet.105.095059  0.508
2005 Saghatelian A, Cravatt BF. Assignment of protein function in the postgenomic era. Nature Chemical Biology. 1: 130-42. PMID 16408016 DOI: 10.1038/Nchembio0805-130  0.592
2005 Alexander JP, Cravatt BF. Mechanism of carbamate inactivation of FAAH: implications for the design of covalent inhibitors and in vivo functional probes for enzymes. Chemistry & Biology. 12: 1179-87. PMID 16298297 DOI: 10.1016/J.Chembiol.2005.08.011  0.459
2005 Evans MJ, Saghatelian A, Sorensen EJ, Cravatt BF. Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling. Nature Biotechnology. 23: 1303-7. PMID 16200062 DOI: 10.1038/Nbt1149  0.637
2005 Cravatt BF. Live chemical reports from the cell surface. Chemistry & Biology. 12: 954-6; discussion 99. PMID 16183017 DOI: 10.1016/J.Chembiol.2005.09.001  0.314
2005 Drahl C, Cravatt BF, Sorensen EJ. Protein-reactive natural products. Angewandte Chemie (International Ed. in English). 44: 5788-809. PMID 16149114 DOI: 10.1002/Anie.200500900  0.392
2005 Osei-Hyiaman D, Depetrillo M, Harvey-White J, Bannon AW, Cravatt BF, Kuhar MJ, Mackie K, Palkovits M, Kunos G. Cocaine- and amphetamine-related transcript is involved in the orexigenic effect of endogenous anandamide. Neuroendocrinology. 81: 273-82. PMID 16131814 DOI: 10.1159/000087925  0.303
2005 Jessani N, Niessen S, Wei BQ, Nicolau M, Humphrey M, Ji Y, Han W, Noh DY, Yates JR, Jeffrey SS, Cravatt BF. A streamlined platform for high-content functional proteomics of primary human specimens. Nature Methods. 2: 691-7. PMID 16118640 DOI: 10.1038/Nmeth778  0.759
2005 Speers AE, Cravatt BF. A tandem orthogonal proteolysis strategy for high-content chemical proteomics. Journal of the American Chemical Society. 127: 10018-9. PMID 16011363 DOI: 10.1021/Ja0532842  0.77
2005 Högestätt ED, Jönsson BA, Ermund A, Andersson DA, Björk H, Alexander JP, Cravatt BF, Basbaum AI, Zygmunt PM. Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system. The Journal of Biological Chemistry. 280: 31405-12. PMID 15987694 DOI: 10.1074/Jbc.M501489200  0.367
2005 Saghatelian A, Cravatt BF. Discovery metabolite profiling--forging functional connections between the proteome and metabolome. Life Sciences. 77: 1759-66. PMID 15964030 DOI: 10.1016/J.Lfs.2005.05.019  0.655
2005 McKinney MK, Cravatt BF. Structure and function of fatty acid amide hydrolase. Annual Review of Biochemistry. 74: 411-32. PMID 15952893 DOI: 10.1146/Annurev.Biochem.74.082803.133450  0.787
2005 Cravatt BF. Kinase chemical genomics--a new rule for the exceptions. Nature Methods. 2: 411-2. PMID 15908917 DOI: 10.1038/Nmeth0605-411  0.323
2005 Lichtman AH, Cravatt BF. Food for thought: endocannabinoid modulation of lipogenesis. The Journal of Clinical Investigation. 115: 1130-3. PMID 15864340 DOI: 10.1172/Jci25076  0.54
2005 Nomura DK, Leung D, Chiang KP, Quistad GB, Cravatt BF, Casida JE. A brain detoxifying enzyme for organophosphorus nerve poisons. Proceedings of the National Academy of Sciences of the United States of America. 102: 6195-200. PMID 15840715 DOI: 10.1073/Pnas.0501915102  0.681
2005 Pacher P, Bátkai S, Osei-Hyiaman D, Offertáler L, Liu J, Harvey-White J, Brassai A, Járai Z, Cravatt BF, Kunos G. Hemodynamic profile, responsiveness to anandamide, and baroreflex sensitivity of mice lacking fatty acid amide hydrolase. American Journal of Physiology. Heart and Circulatory Physiology. 289: H533-41. PMID 15821037 DOI: 10.1152/Ajpheart.00107.2005  0.334
2005 Boger DL, Miyauchi H, Du W, Hardouin C, Fecik RA, Cheng H, Hwang I, Hedrick MP, Leung D, Acevedo O, Guimarães CR, Jorgensen WL, Cravatt BF. Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics. Journal of Medicinal Chemistry. 48: 1849-56. PMID 15771430 DOI: 10.1021/Jm049614V  0.538
2005 Jessani N, Young JA, Diaz SL, Patricelli MP, Varki A, Cravatt BF. Class assignment of sequence-unrelated members of enzyme superfamilies by activity-based protein profiling. Angewandte Chemie (International Ed. in English). 44: 2400-3. PMID 15765498 DOI: 10.1002/Anie.200463098  0.81
2005 Go EP, Apon JV, Luo G, Saghatelian A, Daniels RH, Sahi V, Dubrow R, Cravatt BF, Vertes A, Siuzdak G. Desorption/ionization on silicon nanowires. Analytical Chemistry. 77: 1641-6. PMID 15762567 DOI: 10.1021/Ac048460O  0.53
2005 Leung D, Du W, Hardouin C, Cheng H, Hwang I, Cravatt BF, Boger DL. Discovery of an exceptionally potent and selective class of fatty acid amide hydrolase inhibitors enlisting proteome-wide selectivity screening: concurrent optimization of enzyme inhibitor potency and selectivity. Bioorganic & Medicinal Chemistry Letters. 15: 1423-8. PMID 15713400 DOI: 10.1016/J.Bmcl.2004.12.085  0.542
2005 Saghatelian A, Cravatt BF. Global strategies to integrate the proteome and metabolome. Current Opinion in Chemical Biology. 9: 62-8. PMID 15701455 DOI: 10.1016/J.Cbpa.2004.12.004  0.635
2005 Jessani N, Niessen S, Mueller BM, Cravatt BF. Breast cancer cell lines grown in vivo: what goes in isn't always the same as what comes out. Cell Cycle (Georgetown, Tex.). 4: 253-5. PMID 15655359 DOI: 10.4161/Cc.4.2.1492  0.716
2005 Patel S, Carrier EJ, Ho WS, Rademacher DJ, Cunningham S, Reddy DS, Falck JR, Cravatt BF, Hillard CJ. The postmortal accumulation of brain N-arachidonylethanolamine (anandamide) is dependent upon fatty acid amide hydrolase activity. Journal of Lipid Research. 46: 342-9. PMID 15576840 DOI: 10.1194/Jlr.M400377-Jlr200  0.308
2005 Patel S, Cravatt BF, Hillard CJ. Synergistic interactions between cannabinoids and environmental stress in the activation of the central amygdala. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 30: 497-507. PMID 15280883 DOI: 10.1038/Sj.Npp.1300535  0.32
2005 Saghatelian A, Cravatt BF. Erratum: Corrigendum: Assignment of protein function in the postgenomic era Nature Chemical Biology. 1: 233-233. DOI: 10.1038/Nchembio0905-233  0.566
2005 Sieber SA, Mondala TS, Head SR, Cravatt BF. Microarray Platform for Profiling Enzyme Activities in Complex Proteomes [J. Am. Chem. Soc.2004,126, 15640−15641]. Journal of the American Chemical Society. 127: 4114-4114. DOI: 10.1021/Ja0506915  0.591
2004 Sieber SA, Mondala TS, Head SR, Cravatt BF. Microarray platform for profiling enzyme activities in complex proteomes Journal of the American Chemical Society. 126: 15640-15641. PMID 15571375 DOI: 10.1021/JA044286+  0.629
2004 Barglow KT, Cravatt BF. Discovering disease-associated enzymes by proteome reactivity profiling. Chemistry & Biology. 11: 1523-31. PMID 15556003 DOI: 10.1016/J.Chembiol.2004.08.023  0.821
2004 Saghatelian A, Trauger SA, Want EJ, Hawkins EG, Siuzdak G, Cravatt BF. Assignment of endogenous substrates to enzymes by global metabolite profiling. Biochemistry. 43: 14332-9. PMID 15533037 DOI: 10.1021/Bi0480335  0.648
2004 Azad SC, Monory K, Marsicano G, Cravatt BF, Lutz B, Zieglgänsberger W, Rammes G. Circuitry for associative plasticity in the amygdala involves endocannabinoid signaling. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 9953-61. PMID 15525780 DOI: 10.1523/Jneurosci.2134-04.2004  0.334
2004 Egertová M, Michael GJ, Cravatt BF, Elphick MR. Fatty acid amide hydrolase in brain ventricular epithelium: mutually exclusive patterns of expression in mouse and rat. Journal of Chemical Neuroanatomy. 28: 171-81. PMID 15482903 DOI: 10.1016/J.Jchemneu.2004.07.001  0.599
2004 Cravatt BF, Lichtman AH. The endogenous cannabinoid system and its role in nociceptive behavior. Journal of Neurobiology. 61: 149-60. PMID 15362158 DOI: 10.1002/Neu.20080  0.561
2004 Jessani N, Humphrey M, McDonald WH, Niessen S, Masuda K, Gangadharan B, Yates JR, Mueller BM, Cravatt BF. Carcinoma and stromal enzyme activity profiles associated with breast tumor growth in vivo. Proceedings of the National Academy of Sciences of the United States of America. 101: 13756-61. PMID 15356343 DOI: 10.1073/Pnas.0404727101  0.746
2004 Chiang KP, Gerber AL, Sipe JC, Cravatt BF. Reduced cellular expression and activity of the P129T mutant of human fatty acid amide hydrolase: evidence for a link between defects in the endocannabinoid system and problem drug use. Human Molecular Genetics. 13: 2113-9. PMID 15254019 DOI: 10.1093/Hmg/Ddh216  0.362
2004 Cravatt BF, Saghatelian A, Hawkins EG, Clement AB, Bracey MH, Lichtman AH. Functional disassociation of the central and peripheral fatty acid amide signaling systems. Proceedings of the National Academy of Sciences of the United States of America. 101: 10821-6. PMID 15247426 DOI: 10.1073/Pnas.0401292101  0.686
2004 Gulyas AI, Cravatt BF, Bracey MH, Dinh TP, Piomelli D, Boscia F, Freund TF. Segregation of two endocannabinoid-hydrolyzing enzymes into pre- and postsynaptic compartments in the rat hippocampus, cerebellum and amygdala. The European Journal of Neuroscience. 20: 441-58. PMID 15233753 DOI: 10.1111/J.1460-9568.2004.03428.X  0.307
2004 Lichtman AH, Leung D, Shelton CC, Saghatelian A, Hardouin C, Boger DL, Cravatt BF. Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity. The Journal of Pharmacology and Experimental Therapeutics. 311: 441-8. PMID 15229230 DOI: 10.1124/Jpet.104.069401  0.767
2004 Saghatelian A, Jessani N, Joseph A, Humphrey M, Cravatt BF. Activity-based probes for the proteomic profiling of metalloproteases. Proceedings of the National Academy of Sciences of the United States of America. 101: 10000-5. PMID 15220480 DOI: 10.1073/Pnas.0402784101  0.828
2004 Ortega-Gutiérrez S, Hawkins EG, Viso A, López-Rodríguez ML, Cravatt BF. Comparison of anandamide transport in FAAH wild-type and knockout neurons: evidence for contributions by both FAAH and the CB1 receptor to anandamide uptake. Biochemistry. 43: 8184-90. PMID 15209515 DOI: 10.1021/Bi049395F  0.336
2004 Bracey MH, Cravatt BF, Stevens RC. Structural commonalities among integral membrane enzymes. Febs Letters. 567: 159-65. PMID 15178315 DOI: 10.1016/J.Febslet.2004.04.084  0.326
2004 Lichtman AH, Shelton CC, Advani T, Cravatt BF. Mice lacking fatty acid amide hydrolase exhibit a cannabinoid receptor-mediated phenotypic hypoalgesia. Pain. 109: 319-27. PMID 15157693 DOI: 10.1016/J.Pain.2004.01.022  0.533
2004 Speers AE, Cravatt BF. Profiling enzyme activities in vivo using click chemistry methods. Chemistry & Biology. 11: 535-46. PMID 15123248 DOI: 10.1016/J.Chembiol.2004.03.012  0.773
2004 Massa F, Marsicano G, Hermann H, Cannich A, Monory K, Cravatt BF, Ferri GL, Sibaev A, Storr M, Lutz B. The endogenous cannabinoid system protects against colonic inflammation. The Journal of Clinical Investigation. 113: 1202-9. PMID 15085199 DOI: 10.1172/Jci19465  0.335
2004 Jessani N, Cravatt BF. The development and application of methods for activity-based protein profiling. Current Opinion in Chemical Biology. 8: 54-9. PMID 15036157 DOI: 10.1016/J.Cbpa.2003.11.004  0.754
2004 Adam GC, Burbaum J, Kozarich JW, Patricelli MP, Cravatt BF. Mapping enzyme active sites in complex proteomes. Journal of the American Chemical Society. 126: 1363-8. PMID 14759193 DOI: 10.1021/Ja038441G  0.819
2004 Speers AE, Cravatt BF. Chemical strategies for activity-based proteomics. Chembiochem : a European Journal of Chemical Biology. 5: 41-7. PMID 14695510 DOI: 10.1002/Cbic.200300721  0.772
2003 Kustedjo K, Deechongkit S, Kelly JW, Cravatt BF. Recombinant expression, purification, and comparative characterization of torsinA and its torsion dystonia-associated variant Delta E-torsinA. Biochemistry. 42: 15333-41. PMID 14690443 DOI: 10.1021/Bi0349569  0.796
2003 Adam GC, Vanderwal CD, Sorensen EJ, Cravatt BF. (-)-FR182877 is a potent and selective inhibitor of carboxylesterase-1. Angewandte Chemie (International Ed. in English). 42: 5480-4. PMID 14618582 DOI: 10.1002/Anie.200352576  0.721
2003 Cravatt BF, Lichtman AH. Fatty acid amide hydrolase: an emerging therapeutic target in the endocannabinoid system. Current Opinion in Chemical Biology. 7: 469-75. PMID 12941421 DOI: 10.1016/S1367-5931(03)00079-6  0.597
2003 Egertová M, Cravatt BF, Elphick MR. Comparative analysis of fatty acid amide hydrolase and cb(1) cannabinoid receptor expression in the mouse brain: evidence of a widespread role for fatty acid amide hydrolase in regulation of endocannabinoid signaling. Neuroscience. 119: 481-96. PMID 12770562 DOI: 10.1016/S0306-4522(03)00145-3  0.589
2003 Leung D, Hardouin C, Boger DL, Cravatt BF. Discovering potent and selective reversible inhibitors of enzymes in complex proteomes. Nature Biotechnology. 21: 687-91. PMID 12740587 DOI: 10.1038/Nbt826  0.591
2003 Clement AB, Hawkins EG, Lichtman AH, Cravatt BF. Increased seizure susceptibility and proconvulsant activity of anandamide in mice lacking fatty acid amide hydrolase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 3916-23. PMID 12736361 DOI: 10.1523/Jneurosci.23-09-03916.2003  0.54
2003 McKinney MK, Cravatt BF. Evidence for distinct roles in catalysis for residues of the serine-serine-lysine catalytic triad of fatty acid amide hydrolase. The Journal of Biological Chemistry. 278: 37393-9. PMID 12734197 DOI: 10.1074/Jbc.M303922200  0.789
2003 Speers AE, Adam GC, Cravatt BF. Activity-based protein profiling in vivo using a copper(i)-catalyzed azide-alkyne [3 + 2] cycloaddition. Journal of the American Chemical Society. 125: 4686-7. PMID 12696868 DOI: 10.1021/Ja034490H  0.82
2003 Aebersold R, Cravatt BF. Proteomics--advances, applications and the challenges that remain. Trends in Biotechnology. 20: S1-2. PMID 12570151 DOI: 10.1016/S1471-1931(02)00206-9  0.353
2002 Cravatt BF, Lichtman AH. The enzymatic inactivation of the fatty acid amide class of signaling lipids. Chemistry and Physics of Lipids. 121: 135-48. PMID 12505696 DOI: 10.1016/S0009-3084(02)00147-0  0.581
2002 Bracey MH, Hanson MA, Masuda KR, Stevens RC, Cravatt BF. Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling. Science (New York, N.Y.). 298: 1793-6. PMID 12459591 DOI: 10.1126/Science.1076535  0.381
2002 Adam GC, Sorensen EJ, Cravatt BF. Trifunctional chemical probes for the consolidated detection and identification of enzyme activities from complex proteomes. Molecular & Cellular Proteomics : McP. 1: 828-835. PMID 12438565 DOI: 10.1074/Mcp.T200007-Mcp200  0.758
2002 Adam GC, Sorensen EJ, Cravatt BF. Chemical strategies for functional proteomics. Molecular & Cellular Proteomics : McP. 1: 781-790. PMID 12438561 DOI: 10.1074/Mcp.R200006-Mcp200  0.736
2002 Jessani N, Liu Y, Humphrey M, Cravatt BF. Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness. Proceedings of the National Academy of Sciences of the United States of America. 99: 10335-40. PMID 12149457 DOI: 10.1073/Pnas.162187599  0.765
2002 Waleh NS, Cravatt BF, Apte-Deshpande A, Terao A, Kilduff TS. Transcriptional regulation of the mouse fatty acid amide hydrolase gene. Gene. 291: 203-10. PMID 12095693 DOI: 10.1016/S0378-1119(02)00598-X  0.337
2002 Adam GC, Sorensen EJ, Cravatt BF. Proteomic profiling of mechanistically distinct enzyme classes using a common chemotype Nature Biotechnology. 20: 805-809. PMID 12091914 DOI: 10.1038/Nbt714  0.768
2002 Lichtman AH, Hawkins EG, Griffin G, Cravatt BF. Pharmacological activity of fatty acid amides is regulated, but not mediated, by fatty acid amide hydrolase in vivo. The Journal of Pharmacology and Experimental Therapeutics. 302: 73-9. PMID 12065702 DOI: 10.1124/Jpet.302.1.73  0.581
2001 Larsen NA, Heine A, Crane L, Cravatt BF, Lerner RA, Wilson IA. Structural basis for a disfavored elimination reaction in catalytic antibody 1D4. Journal of Molecular Biology. 314: 93-102. PMID 11724535 DOI: 10.1006/Jmbi.2001.5112  0.461
2001 Cravatt BF, Demarest K, Patricelli MP, Bracey MH, Giang DK, Martin BR, Lichtman AH. Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase. Proceedings of the National Academy of Sciences of the United States of America. 98: 9371-6. PMID 11470906 DOI: 10.1073/Pnas.161191698  0.801
2001 Patricelli MP, Cravatt BF. Characterization and manipulation of the acyl chain selectivity of fatty acid amide hydrolase. Biochemistry. 40: 6107-15. PMID 11352748 DOI: 10.1021/Bi002578R  0.715
2001 Patricelli MP, Cravatt BF. Proteins regulating the biosynthesis and inactivation of neuromodulatory fatty acid amides. Vitamins and Hormones. 62: 95-131. PMID 11345902 DOI: 10.1016/S0083-6729(01)62002-8  0.706
2001 Kidd D, Liu Y, Cravatt BF. Profiling serine hydrolase activities in complex proteomes. Biochemistry. 40: 4005-15. PMID 11300781 DOI: 10.1021/Bi002579J  0.445
2001 Adam GC, Cravatt BF, Sorensen EJ. Profiling the specific reactivity of the proteome with non-directed activity-based probes Chemistry and Biology. 8: 81-95. PMID 11182321 DOI: 10.1016/S1074-5521(00)90060-7  0.759
2001 Cravatt B, Liu Y. Chemical strategies for the global analysis of protein function: Profiling hydrolytic enzymes in cancer Nature Genetics. 27: 49-49. DOI: 10.1038/87050  0.406
2000 Boger DL, Fecik RA, Patterson JE, Miyauchi H, Patricelli MP, Cravatt BF. Fatty acid amide hydrolase substrate specificity. Bioorganic & Medicinal Chemistry Letters. 10: 2613-6. PMID 11128635 DOI: 10.1016/S0960-894X(00)00528-X  0.721
2000 Cravatt BF, Sorensen EJ. Chemical strategies for the global analysis of protein function Current Opinion in Chemical Biology. 4: 663-668. PMID 11102872 DOI: 10.1016/S1367-5931(00)00147-2  0.313
2000 Wang EW, Kessler BM, Borodovsky A, Cravatt BF, Bogyo M, Ploegh HL, Glas R. Integration of the ubiquitin-proteasome pathway with a cytosolic oligopeptidase activity. Proceedings of the National Academy of Sciences of the United States of America. 97: 9990-5. PMID 10954757 DOI: 10.1073/Pnas.180328897  0.379
2000 Kustedjo K, Bracey MH, Cravatt BF. Torsin A and its torsion dystonia-associated mutant forms are lumenal glycoproteins that exhibit distinct subcellular localizations. The Journal of Biological Chemistry. 275: 27933-9. PMID 10871631 DOI: 10.1074/Jbc.M910025199  0.797
2000 Boger DL, Sato H, Lerner AE, Hedrick MP, Fecik RA, Miyauchi H, Wilkie GD, Austin BJ, Patricelli MP, Cravatt BF. Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide. Proceedings of the National Academy of Sciences of the United States of America. 97: 5044-9. PMID 10805767 DOI: 10.1073/Pnas.97.10.5044  0.807
2000 Patricelli MP, Cravatt BF. Clarifying the catalytic roles of conserved residues in the amidase signature family. The Journal of Biological Chemistry. 275: 19177-84. PMID 10764768 DOI: 10.1074/Jbc.M001607200  0.72
2000 Egertová M, Cravatt BF, Elphick MR. Fatty acid amide hydrolase expression in rat choroid plexus: possible role in regulation of the sleep-inducing action of oleamide. Neuroscience Letters. 282: 13-6. PMID 10713385 DOI: 10.1016/S0304-3940(00)00841-7  0.586
1999 Liu Y, Patricelli MP, Cravatt BF. Activity-based protein profiling: the serine hydrolases. Proceedings of the National Academy of Sciences of the United States of America. 96: 14694-9. PMID 10611275 DOI: 10.1073/Pnas.96.26.14694  0.722
1999 Patricelli MP, Cravatt BF. Fatty acid amide hydrolase competitively degrades bioactive amides and esters through a nonconventional catalytic mechanism. Biochemistry. 38: 14125-30. PMID 10571985 DOI: 10.1021/Bi991876P  0.714
1999 Patricelli MP, Lovato MA, Cravatt BF. Chemical and mutagenic investigations of fatty acid amide hydrolase: evidence for a family of serine hydrolases with distinct catalytic properties. Biochemistry. 38: 9804-12. PMID 10433686 DOI: 10.1021/Bi990637Z  0.71
1999 Thomas EA, Cravatt BF, Sutcliffe JG. The endogenous lipid oleamide activates serotonin 5-HT7 neurons in mouse thalamus and hypothalamus. Journal of Neurochemistry. 72: 2370-8. PMID 10349846 DOI: 10.1046/J.1471-4159.1999.0722370.X  0.563
1999 Boger DL, Sato H, Lerner AE, Austin BJ, Patterson JE, Patricelli MP, Cravatt BF. Trifluoromethyl ketone inhibitors of fatty acid amide hydrolase: a probe of structural and conformational features contributing to inhibition. Bioorganic & Medicinal Chemistry Letters. 9: 265-70. PMID 10021942 DOI: 10.1016/S0960-894X(98)00734-3  0.739
1998 Boger DL, Henriksen SJ, Cravatt BF. Oleamide: an endogenous sleep-inducing lipid and prototypical member of a new class of biological signaling molecules. Current Pharmaceutical Design. 4: 303-14. PMID 10197045  0.426
1998 Wan M, Cravatt BF, Ring HZ, Zhang X, Francke U. Conserved chromosomal location and genomic structure of human and mouse fatty-acid amide hydrolase genes and evaluation of clasper as a candidate neurological mutation. Genomics. 54: 408-14. PMID 9878243 DOI: 10.1006/Geno.1998.5597  0.315
1998 Patricelli MP, Patterson JE, Boger DL, Cravatt BF. An endogenous sleep-inducing compound is a novel competitive inhibitor of fatty acid amide hydrolase. Bioorganic & Medicinal Chemistry Letters. 8: 613-8. PMID 9871570 DOI: 10.1016/S0960-894X(98)00073-0  0.727
1998 Egertová M, Giang DK, Cravatt BF, Elphick MR. A new perspective on cannabinoid signalling: complementary localization of fatty acid amide hydrolase and the CB1 receptor in rat brain. Proceedings. Biological Sciences / the Royal Society. 265: 2081-5. PMID 9842734 DOI: 10.1098/Rspb.1998.0543  0.605
1998 Patricelli MP, Lashuel HA, Giang DK, Kelly JW, Cravatt BF. Comparative characterization of a wild type and transmembrane domain-deleted fatty acid amide hydrolase: identification of the transmembrane domain as a site for oligomerization. Biochemistry. 37: 15177-87. PMID 9790682 DOI: 10.1021/Bi981733N  0.702
1998 Boger DL, Patterson JE, Guan X, Cravatt BF, Lerner RA, Gilula NB. Chemical requirements for inhibition of gap junction communication by the biologically active lipid oleamide. Proceedings of the National Academy of Sciences of the United States of America. 95: 4810-5. PMID 9560184 DOI: 10.1073/Pnas.95.9.4810  0.617
1998 Giang DK, Cravatt BF. A second mammalian N-myristoyltransferase. The Journal of Biological Chemistry. 273: 6595-8. PMID 9506952 DOI: 10.1074/Jbc.273.12.6595  0.417
1997 Thomas EA, Cravatt BF, Danielson PE, Gilula NB, Sutcliffe JG. Fatty acid amide hydrolase, the degradative enzyme for anandamide and oleamide, has selective distribution in neurons within the rat central nervous system. Journal of Neuroscience Research. 50: 1047-52. PMID 9452020 DOI: 10.1002/(Sici)1097-4547(19971215)50:6<1047::Aid-Jnr16>3.0.Co;2-1  0.594
1997 Guan X, Cravatt BF, Ehring GR, Hall JE, Boger DL, Lerner RA, Gilula NB. The sleep-inducing lipid oleamide deconvolutes gap junction communication and calcium wave transmission in glial cells. The Journal of Cell Biology. 139: 1785-92. PMID 9412472 DOI: 10.1083/Jcb.139.7.1785  0.56
1997 Arreaza G, Devane WA, Omeir RL, Sajnani G, Kunz J, Cravatt BF, Deutsch DG. The cloned rat hydrolytic enzyme responsible for the breakdown of anandamide also catalyzes its formation via the condensation of arachidonic acid and ethanolamine. Neuroscience Letters. 234: 59-62. PMID 9347946 DOI: 10.1016/S0304-3940(97)00673-3  0.357
1997 Giang DK, Cravatt BF. Molecular characterization of human and mouse fatty acid amide hydrolases. Proceedings of the National Academy of Sciences of the United States of America. 94: 2238-42. PMID 9122178 DOI: 10.1073/Pnas.94.6.2238  0.366
1996 Cravatt BF, Giang DK, Mayfield SP, Boger DL, Lerner RA, Gilula NB. Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. Nature. 384: 83-7. PMID 8900284 DOI: 10.1038/384083A0  0.639
1996 Patterson JE, Ollmann IR, Cravatt BF, Boger DL, Wong CH, Lerner RA. Inhibition of oleamide hydrolase catalyzed hydrolysis of the endogenous sleep-inducing lipid cis-9-octadecenamide Journal of the American Chemical Society. 118: 5938-5945. DOI: 10.1021/Ja954064Z  0.606
1996 Cravatt BF, Lerner RA, Boger DL. Structure determination of an endogenous sleep-inducing lipid, cis-9-octadecenamide (oleamide): A synthetic approach to the chemical analysis of trace quantities of a natural product Journal of the American Chemical Society. 118: 580-590. DOI: 10.1021/Ja9532345  0.538
1995 Cravatt BF, Prospero-Garcia O, Siuzdak G, Gilula NB, Henriksen SJ, Boger DL, Lerner RA. Chemical characterization of a family of brain lipids that induce sleep. Science (New York, N.Y.). 268: 1506-9. PMID 7770779 DOI: 10.1126/Science.7770779  0.576
1994 Lerner RA, Siuzdak G, Prospero-Garcia O, Henriksen SJ, Boger DL, Cravatt BF. Cerebrodiene: a brain lipid isolated from sleep-deprived cats. Proceedings of the National Academy of Sciences of the United States of America. 91: 9505-8. PMID 7937797 DOI: 10.1073/Pnas.91.20.9505  0.554
1994 Boger DL, Lerner RA, Cravatt BF. Synthesis of a Functionalized Rigid Bicyclo[2.2.1]heptane: A Useful Hapten for Eliciting Catalytic Antibodies The Journal of Organic Chemistry. 59: 5078-5079. DOI: 10.1021/Jo00096A064  0.537
1994 Cravatt BF, Ashley JA, Janda KD, Boger DL, Lerner RA. Crossing Extreme Mechanistic Barriers by Antibody Catalysis: Syn Elimination to a Cis Olefin Journal of the American Chemical Society. 116: 6013-6014. DOI: 10.1021/Ja00092A080  0.512
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