Lorraine Pillus - Publications

Affiliations: 
Biology University of California, San Diego, La Jolla, CA 
Area:
Molecular Biology, Genetics, Microbiology Biology

80 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Liu Q, Pillus L, Petty EL. Functional tug of war between kinases, phosphatases, and the Gcn5 acetyltransferase in chromatin and cell cycle checkpoint controls. G3 (Bethesda, Md.). PMID 36772957 DOI: 10.1093/g3journal/jkad021  0.432
2020 Petty EL, Pillus L. Cell cycle roles for GCN5 revealed through genetic suppression. Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms. 194625. PMID 32798737 DOI: 10.1016/J.Bbagrm.2020.194625  0.531
2020 Li Y, Jiang Y, Paxman J, O'Laughlin R, Klepin S, Zhu Y, Pillus L, Tsimring LS, Hasty J, Hao N. A programmable fate decision landscape underlies single-cell aging in yeast. Science (New York, N.Y.). 369: 325-329. PMID 32675375 DOI: 10.1126/Science.Aax9552  0.337
2019 Hao N, Li Y, Jiang Y, Paxman J, O’Laughlin R, Pillus L, Tsimring L, Hasty J. WADDINGTON’S LANDSCAPE OF CELL AGING Innovation in Aging. 3: S208-S208. DOI: 10.1093/Geroni/Igz038.755  0.328
2018 Petty EL, Evpak M, Pillus L. Connecting GCN5's centromeric SAGA to the mitotic tension-sensing checkpoint. Molecular Biology of the Cell. mbcE17120701. PMID 29995571 DOI: 10.1091/Mbc.E17-12-0701  0.426
2017 Li Y, Jin M, O'Laughlin R, Bittihn P, Tsimring LS, Pillus L, Hasty J, Hao N. Multigenerational silencing dynamics control cell aging. Proceedings of the National Academy of Sciences of the United States of America. 114: 11253-11258. PMID 29073021 DOI: 10.1073/Pnas.1703379114  0.346
2017 Searle NE, Pillus L. Critical genomic regulation mediated by Enhancer of Polycomb. Current Genetics. PMID 28884217 DOI: 10.1007/S00294-017-0742-3  0.502
2017 Marquez-Lona EM, Torres-Machorro AL, Gonzales FR, Pillus L, Patrick GN. Phosphorylation of the 19S regulatory particle ATPase subunit, Rpt6, modifies susceptibility to proteotoxic stress and protein aggregation. Plos One. 12: e0179893. PMID 28662109 DOI: 10.1371/Journal.Pone.0179893  0.38
2017 Mason AG, Garza RM, McCormick MA, Patel B, Kennedy BK, Pillus L, La Spada AR. The replicative lifespan-extending deletion of SGF73 results in altered ribosomal gene expression in yeast. Aging Cell. PMID 28568901 DOI: 10.1111/Acel.12611  0.506
2017 Searle NE, Torres-Machorro AL, Pillus L. Chromatin Regulation by the NuA4 Acetyltransferase Complex Is Mediated by Essential Interactions Between Enhancer of Polycomb (Epl1) and Esa1. Genetics. PMID 28108589 DOI: 10.1534/Genetics.116.197830  0.572
2016 Petty EL, Lafon A, Tomlinson SL, Mendelsohn BA, Pillus L. Promotion of Cell Viability and Histone Gene Expression by the Acetyltransferase Gcn5 and the Protein Phosphatase PP2A in Saccharomyces cerevisiae. Genetics. PMID 27317677 DOI: 10.1534/Genetics.116.189506  0.623
2016 Su XB, Pillus L. Functions for diverse metabolic activities in heterochromatin. Proceedings of the National Academy of Sciences of the United States of America. PMID 26936955 DOI: 10.1073/Pnas.1518707113  0.503
2015 Torres-Machorro AL, Clark LG, Chang CS, Pillus L. The Set3 Complex Antagonizes the MYST Acetyltransferase Esa1 in the DNA Damage Response. Molecular and Cellular Biology. 35: 3714-25. PMID 26303527 DOI: 10.1128/Mcb.00298-15  0.693
2015 Torres-Machorro AL, Aris JP, Pillus L. A moonlighting metabolic protein influences repair at DNA double-stranded breaks. Nucleic Acids Research. 43: 1646-58. PMID 25628362 DOI: 10.1093/Nar/Gku1405  0.501
2014 Basnet H, Su XB, Tan Y, Meisenhelder J, Merkurjev D, Ohgi KA, Hunter T, Pillus L, Rosenfeld MG. Tyrosine phosphorylation of histone H2A by CK2 regulates transcriptional elongation. Nature. 516: 267-71. PMID 25252977 DOI: 10.1038/Nature13736  0.572
2014 McCormick MA, Mason AG, Guyenet SJ, Dang W, Garza RM, Ting MK, Moller RM, Berger SL, Kaeberlein M, Pillus L, La Spada AR, Kennedy BK. The SAGA histone deubiquitinase module controls yeast replicative lifespan via Sir2 interaction. Cell Reports. 8: 477-86. PMID 25043177 DOI: 10.1016/J.Celrep.2014.06.037  0.506
2014 Torres-Machorro AL, Pillus L. Bypassing the requirement for an essential MYST acetyltransferase. Genetics. 197: 851-63. PMID 24831819 DOI: 10.1534/Genetics.114.165894  0.536
2014 Eustice M, Pillus L. Unexpected function of the glucanosyltransferase Gas1 in the DNA damage response linked to histone H3 acetyltransferases in Saccharomyces cerevisiae. Genetics. 196: 1029-39. PMID 24532730 DOI: 10.1534/Genetics.113.158824  0.531
2013 Petty E, Pillus L. Balancing chromatin remodeling and histone modifications in transcription. Trends in Genetics : Tig. 29: 621-9. PMID 23870137 DOI: 10.1016/J.Tig.2013.06.006  0.582
2013 Chen M, Licon K, Otsuka R, Pillus L, Ideker T. Decoupling epigenetic and genetic effects through systematic analysis of gene position. Cell Reports. 3: 128-37. PMID 23291096 DOI: 10.1016/J.Celrep.2012.12.003  0.517
2013 Garza R, Pillus L. STUbLs in chromatin and genome stability. Biopolymers. 99: 146-54. PMID 23175389 DOI: 10.1002/Bip.22125  0.532
2012 Lafon A, Petty E, Pillus L. Functional antagonism between Sas3 and Gcn5 acetyltransferases and ISWI chromatin remodelers. Plos Genetics. 8: e1002994. PMID 23055944 DOI: 10.1371/Journal.Pgen.1002994  0.565
2012 Chang CS, Clarke A, Pillus L. Suppression analysis of esa1 mutants in Saccharomyces cerevisiae links NAB3 to transcriptional silencing and nucleolar functions. G3 (Bethesda, Md.). 2: 1223-32. PMID 23050233 DOI: 10.1534/G3.112.003558  0.647
2010 Scott EM, Pillus L. Homocitrate synthase connects amino acid metabolism to chromatin functions through Esa1 and DNA damage. Genes & Development. 24: 1903-13. PMID 20810648 DOI: 10.1101/Gad.1935910  0.511
2010 Bulfer SL, Scott EM, Pillus L, Trievel RC. Structural basis for L-lysine feedback inhibition of homocitrate synthase. The Journal of Biological Chemistry. 285: 10446-53. PMID 20089861 DOI: 10.1074/Jbc.M109.094383  0.347
2010 Koch MR, Pillus L. Silent chromatin formation and regulation in the yeast saccharomyces cerevisiae Handbook of Cell Signaling, 2/E. 3: 2427-2436. DOI: 10.1016/B978-0-12-374145-5.00290-4  0.761
2009 Bulfer SL, Scott EM, Couture JF, Pillus L, Trievel RC. Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis. The Journal of Biological Chemistry. 284: 35769-80. PMID 19776021 DOI: 10.1016/J.Bpj.2009.12.2446  0.326
2009 Jacobson S, Pillus L. The SAGA subunit Ada2 functions in transcriptional silencing. Molecular and Cellular Biology. 29: 6033-45. PMID 19737915 DOI: 10.1128/Mcb.00542-09  0.596
2009 Chang CS, Pillus L. Collaboration between the essential Esa1 acetyltransferase and the Rpd3 deacetylase is mediated by H4K12 histone acetylation in Saccharomyces cerevisiae. Genetics. 183: 149-60. PMID 19596907 DOI: 10.1534/Genetics.109.103846  0.735
2009 Koch MR, Pillus L. The glucanosyltransferase Gas1 functions in transcriptional silencing. Proceedings of the National Academy of Sciences of the United States of America. 106: 11224-9. PMID 19541632 DOI: 10.1073/Pnas.0900809106  0.777
2009 Mak HC, Pillus L, Ideker T. Dynamic reprogramming of transcription factors to and from the subtelomere. Genome Research. 19: 1014-25. PMID 19372386 DOI: 10.1101/Gr.084178.108  0.479
2009 Kennedy EJ, Yang J, Pillus L, Taylor SS, Ghosh G. Identifying critical non-catalytic residues that modulate protein kinase A activity. Plos One. 4: e4746. PMID 19270744 DOI: 10.1371/Journal.Pone.0004746  0.367
2008 Pillus L. MYSTs mark chromatin for chromosomal functions. Current Opinion in Cell Biology. 20: 326-33. PMID 18511253 DOI: 10.1016/J.Ceb.2008.04.009  0.497
2008 Darst RP, Garcia SN, Koch MR, Pillus L. Slx5 promotes transcriptional silencing and is required for robust growth in the absence of Sir2. Molecular and Cellular Biology. 28: 1361-72. PMID 18086879 DOI: 10.1128/Mcb.01291-07  0.772
2008 Kennedy EJ, Ghosh G, Pillus L. Identification of functionally distinct regions that mediate biological activity of the protein kinase a homolog Tpk2. The Journal of Biological Chemistry. 283: 1084-93. PMID 17971450 DOI: 10.1074/Jbc.M704028200  0.343
2008 Darst RP, Garcia SN, Koch MR, Pillus L. Slx5 promotes transcriptional silencing and is required for robust growth in the absence of Sir2 (Molecular and Cellular Biology (2008) 28, 4, (1361-1372)) Molecular and Cellular Biology. 28: 7532. DOI: 10.1128/MCB.01664-08  0.697
2007 Allis CD, Berger SL, Cote J, Dent S, Jenuwien T, Kouzarides T, Pillus L, Reinberg D, Shi Y, Shiekhattar R, Shilatifard A, Workman J, Zhang Y. New nomenclature for chromatin-modifying enzymes. Cell. 131: 633-6. PMID 18022353 DOI: 10.1016/J.Cell.2007.10.039  0.314
2007 Lafon A, Chang CS, Scott EM, Jacobson SJ, Pillus L. MYST opportunities for growth control: yeast genes illuminate human cancer gene functions. Oncogene. 26: 5373-84. PMID 17694079 DOI: 10.1038/Sj.Onc.1210606  0.698
2006 Wilson JM, Le VQ, Zimmerman C, Marmorstein R, Pillus L. Nuclear export modulates the cytoplasmic Sir2 homologue Hst2. Embo Reports. 7: 1247-51. PMID 17110954 DOI: 10.1038/Sj.Embor.7400829  0.659
2006 Ruault M, Pillus L. Chromatin-modifiying enzymes are essential when the Saccharomyces cerevisiae morphogenesis checkpoint is constitutively activated. Genetics. 174: 1135-49. PMID 16951088 DOI: 10.1534/Genetics.106.059873  0.486
2006 Clarke AS, Samal E, Pillus L. Distinct roles for the essential MYST family HAT Esa1p in transcriptional silencing. Molecular Biology of the Cell. 17: 1744-57. PMID 16436512 DOI: 10.1091/Mbc.E05-07-0613  0.561
2005 Kennedy EJ, Pillus L, Ghosh G. Pho5p and newly identified nucleotide pyrophosphatases/ phosphodiesterases regulate extracellular nucleotide phosphate metabolism in Saccharomyces cerevisiae. Eukaryotic Cell. 4: 1892-901. PMID 16278456 DOI: 10.1128/Ec.4.11.1892-1901.2005  0.351
2005 Pillus L, Rine J. SIR1 and the origin of epigenetic states in Saccharomyces cerevisiae. Cold Spring Harbor Symposia On Quantitative Biology. 69: 259-65. PMID 16117657 DOI: 10.1101/Sqb.2004.69.259  0.36
2005 Wirén M, Silverstein RA, Sinha I, Walfridsson J, Lee HM, Laurenson P, Pillus L, Robyr D, Grunstein M, Ekwall K. Genomewide analysis of nucleosome density histone acetylation and HDAC function in fission yeast. The Embo Journal. 24: 2906-18. PMID 16079916 DOI: 10.1038/Sj.Emboj.7600758  0.511
2005 Lo WS, Gamache ER, Henry KW, Yang D, Pillus L, Berger SL. Histone H3 phosphorylation can promote TBP recruitment through distinct promoter-specific mechanisms. The Embo Journal. 24: 997-1008. PMID 15719021 DOI: 10.1038/Sj.Emboj.7600577  0.58
2005 Freeman-Cook LL, Gómez EB, Spedale EJ, Marlett J, Forsburg SL, Pillus L, Laurenson P. Conserved locus-specific silencing functions of Schizosaccharomyces pombe sir2+. Genetics. 169: 1243-60. PMID 15545655 DOI: 10.1534/Genetics.104.032714  0.538
2004 Jacobson S, Pillus L. Molecular requirements for gene expression mediated by targeted histone acetyltransferases. Molecular and Cellular Biology. 24: 6029-39. PMID 15199156 DOI: 10.1128/Mcb.24.13.6029-6039.2004  0.535
2004 Jacobson SJ, Laurenson PM, Pillus L. Functional analyses of chromatin modifications in yeast. Methods in Enzymology. 377: 3-55. PMID 14979016 DOI: 10.1016/S0076-6879(03)77001-3  0.511
2003 Murphy GA, Spedale EJ, Powell ST, Pillus L, Schultz SC, Chen L. The Sir4 C-terminal coiled coil is required for telomeric and mating type silencing in Saccharomyces cerevisiae. Journal of Molecular Biology. 334: 769-80. PMID 14636601 DOI: 10.1016/J.Jmb.2003.09.066  0.365
2003 Henry KW, Wyce A, Lo WS, Duggan LJ, Emre NC, Kao CF, Pillus L, Shilatifard A, Osley MA, Berger SL. Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8. Genes & Development. 17: 2648-63. PMID 14563679 DOI: 10.1101/Gad.1144003  0.582
2003 Clements A, Poux AN, Lo WS, Pillus L, Berger SL, Marmorstein R. Structural basis for histone and phosphohistone binding by the GCN5 histone acetyltransferase. Molecular Cell. 12: 461-73. PMID 14536085 DOI: 10.1016/S1097-2765(03)00288-0  0.54
2003 Parsons XH, Garcia SN, Pillus L, Kadonaga JT. Histone deacetylation by Sir2 generates a transcriptionally repressed nucleoprotein complex. Proceedings of the National Academy of Sciences of the United States of America. 100: 1609-14. PMID 12571358 DOI: 10.1073/Pnas.0434064100  0.563
2002 Garcia SN, Pillus L. A unique class of conditional sir2 mutants displays distinct silencing defects in Saccharomyces cerevisiae. Genetics. 162: 721-36. PMID 12399383  0.45
2001 Howe L, Auston D, Grant P, John S, Cook RG, Workman JL, Pillus L. Histone H3 specific acetyltransferases are essential for cell cycle progression. Genes & Development. 15: 3144-54. PMID 11731478 DOI: 10.1101/Gad.931401  0.441
2001 Dutnall RN, Pillus L. Deciphering NAD-dependent deacetylases. Cell. 105: 161-4. PMID 11336664 DOI: 10.1016/S0092-8674(01)00305-1  0.379
2000 Landry J, Sutton A, Tafrov ST, Heller RC, Stebbins J, Pillus L, Sternglanz R. The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases Proceedings of the National Academy of Sciences of the United States of America. 97: 5807-5811. PMID 10811920 DOI: 10.1073/Pnas.110148297  0.581
2000 Stone EM, Heun P, Laroche T, Pillus L, Gasser SM. MAP kinase signaling induces nuclear reorganization in budding yeast. Current Biology : Cb. 10: 373-82. PMID 10753745 DOI: 10.1016/S0960-9822(00)00413-9  0.387
2000 Nislow C, Ray E, Pillus L. SET1, a yeast member of the trithorax family, functions in transcriptional silencing and diverse cellular processes. Molecular Biology of the Cell. 8: 2421-36. PMID 9398665 DOI: 10.1091/Mbc.8.12.2421  0.462
1999 Freeman-Cook LL, Sherman JM, Brachmann CB, Allshire RC, Boeke JD, Pillus L. The Schizosaccharomyces pombe hst4(+) gene is a SIR2 homologue with silencing and centromeric functions. Molecular Biology of the Cell. 10: 3171-86. PMID 10512858 DOI: 10.1091/Mbc.10.10.3171  0.534
1999 Allard S, Utley RT, Savard J, Clarke A, Grant P, Brandl CJ, Pillus L, Workman JL, Côté J. NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p. The Embo Journal. 18: 5108-19. PMID 10487762 DOI: 10.1093/Emboj/18.18.5108  0.586
1999 Sherman JM, Stone EM, Freeman-Cook LL, Brachmann CB, Boeke JD, Pillus L. The conserved core of a human SIR2 homologue functions in yeast silencing. Molecular Biology of the Cell. 10: 3045-59. PMID 10473645 DOI: 10.1091/Mbc.10.9.3045  0.518
1999 Garcia SN, Pillus L. Net results of nucleolar dynamics. Cell. 97: 825-8. PMID 10399910 DOI: 10.1016/S0092-8674(00)80794-1  0.395
1999 Jacobson S, Pillus L. Modifying chromatin and concepts of cancer. Current Opinion in Genetics & Development. 9: 175-84. PMID 10322138 DOI: 10.1016/S0959-437X(99)80027-6  0.512
1999 Clarke AS, Lowell JE, Jacobson SJ, Pillus L. Esa1p is an essential histone acetyltransferase required for cell cycle progression Molecular and Cellular Biology. 19: 2515-2526. PMID 10082517 DOI: 10.1128/Mcb.19.4.2515  0.611
1999 Allard S, Utley RT, Savard J, Clarke A, Grant P, Brandl CJ, Pillus L, Workman JL, Côté J. The NuA4 transcription activation/histone H4 acetyltransferase complex contains the essential Esa1 protein as the catalytic subunit and the essential ATM-related cofactor Tra1p Biochemistry and Cell Biology. 77: 383. DOI: 10.1139/O99-903  0.456
1998 Stone EM, Pillus L. Silent chromatin in yeast: an orchestrated medley featuring Sir3p [corrected]. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 20: 30-40. PMID 9504045 DOI: 10.1002/(Sici)1521-1878(199801)20:1<30::Aid-Bies6>3.0.Co;2-W  0.59
1998 Lowell JE, Pillus L. Telomere tales: chromatin, telomerase and telomere function in Saccharomyces cerevisiae. Cellular and Molecular Life Sciences : Cmls. 54: 32-49. PMID 9487385 DOI: 10.1007/S000180050123  0.531
1997 Sherman JM, Pillus L. An uncertain silence. Trends in Genetics : Tig. 13: 308-13. PMID 9260516 DOI: 10.1016/S0168-9525(97)01198-0  0.558
1997 Laible G, Wolf A, Dorn R, Reuter G, Nislow C, Lebersorger A, Popkin D, Pillus L, Jenuwein T. Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S. cerevisiae telomeres. The Embo Journal. 16: 3219-32. PMID 9214638 DOI: 10.1093/Emboj/16.11.3219  0.467
1996 Stone EM, Pillus L. Activation of an MAP kinase cascade leads to Sir3p hyperphosphorylation and strengthens transcriptional silencing. The Journal of Cell Biology. 135: 571-83. PMID 8909534 DOI: 10.1083/Jcb.135.3.571  0.493
1996 Reifsnyder C, Lowell J, Clarke A, Pillus L. Yeast SAS silencing genes and human genes associated with AML and HIV-1 Tat interactions are homologous with acetyltransferases. Nature Genetics. 14: 42-9. PMID 8782818 DOI: 10.1038/Ng0996-42  0.493
1995 Brachmann CB, Sherman JM, Devine SE, Cameron EE, Pillus L, Boeke JD. The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability. Genes & Development. 9: 2888-902. PMID 7498786 DOI: 10.1101/Gad.9.23.2888  0.509
1994 Rivier DH, Pillus L. Silencing speaks up. Cell. 76: 963-6. PMID 8137430 DOI: 10.1016/0092-8674(94)90373-5  0.503
1993 Palladino F, Laroche T, Gilson E, Axelrod A, Pillus L, Gasser SM. SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres Cell. 75: 543-555. PMID 8221893 DOI: 10.1016/0092-8674(93)90388-7  0.454
1993 Palladino F, Laroche T, Gilson E, Pillus L, Gasser SM. The positioning of yeast telomeres depends on SIR3, SIR4, and the integrity of the nuclear membrane Cold Spring Harbor Symposia On Quantitative Biology. 58: 733-746. PMID 7956091 DOI: 10.1101/Sqb.1993.058.01.081  0.37
1992 Pillus L. An acquired state: epigenetic mechanisms in transcription. Current Opinion in Cell Biology. 4: 453-8. PMID 1497916 DOI: 10.1016/0955-0674(92)90011-Z  0.493
1991 Pillus L. Any which way but loose - determining a transcription state in yeast Bioessays. 13: 303-304. DOI: 10.1002/Bies.950130608  0.389
1990 Pillus L, Rine J. Epigenetic inheritance of transcriptional states in S. cerevisiae. Cell. 59: 637-47. PMID 2684414 DOI: 10.1016/0092-8674(89)90009-3  0.393
1986 Pillus L, Solomon F. Components of microtubular structures in Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America. 83: 2468-72. PMID 3517870 DOI: 10.1073/Pnas.83.8.2468  0.341
1986 Schatz PJ, Pillus L, Grisafi P, Solomon F, Botstein D. Two functional alpha-tubulin genes of the yeast Saccharomyces cerevisiae encode divergent proteins. Molecular and Cellular Biology. 6: 3711-21. PMID 3025610 DOI: 10.1128/Mcb.6.11.3711  0.345
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