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Bruce McClane - Publications

Affiliations: 
University of Pittsburgh, Pittsburgh, PA, United States 
Area:
Microbiology Biology
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39 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Shrestha A, Navarro MA, Beingesser J, Armien AG, Uzal FA, McClane BA. Characterizing the Contributions of Various Clostridium perfringens Enterotoxin Properties to and Permeability Effects. Msphere. e0027622. PMID 36069435 DOI: 10.1128/msphere.00276-22  0.342
2019 Mehdizadeh Gohari I, Li J, Navarro M, Uzal F, McClane B. Effects of Claudin-1 on the Action of Enterotoxin in Caco-2 Cells. Toxins. 11. PMID 31601044 DOI: 10.3390/Toxins11100582  0.386
2019 Navarro MA, Shrestha A, Freedman JC, Beingesser J, McClane BA, Uzal FA. Exploring the Potential Therapeutic Effects of Mepacrine against Enterotoxin in a Mouse Enterotoxemia Model. Infection and Immunity. PMID 30642896 DOI: 10.1128/IAI.00670-18  0.303
2017 Freedman JC, Hendricks MR, McClane BA. The Potential Therapeutic Agent Mepacrine Protects Caco-2 Cells against Clostridium perfringens Enterotoxin Action. Msphere. 2. PMID 28875177 DOI: 10.1128/mSphere.00352-17  0.383
2016 Shrestha A, Uzal FA, McClane BA. The interaction of Clostridium perfringens enterotoxin with receptor claudins. Anaerobe. PMID 27090847 DOI: 10.1016/j.anaerobe.2016.04.011  0.339
2016 Freedman JC, Shrestha A, McClane BA. Clostridium perfringens Enterotoxin: Action, Genetics, and Translational Applications. Toxins. 8. PMID 26999202 DOI: 10.3390/toxins8030073  0.368
2014 Yelland TS, Naylor CE, Bagoban T, Savva CG, Moss DS, McClane BA, Blasig IE, Popoff M, Basak AK. Structure of a C. perfringens enterotoxin mutant in complex with a modified Claudin-2 extracellular loop 2. Journal of Molecular Biology. 426: 3134-47. PMID 25020226 DOI: 10.1016/j.jmb.2014.07.001  0.365
2014 Uzal FA, Freedman JC, Shrestha A, Theoret JR, Garcia J, Awad MM, Adams V, Moore RJ, Rood JI, McClane BA. Towards an understanding of the role of Clostridium perfringens toxins in human and animal disease. Future Microbiology. 9: 361-77. PMID 24762309 DOI: 10.2217/fmb.13.168  0.302
2014 Garcia JP, Li J, Shrestha A, Freedman JC, Beingesser J, McClane BA, Uzal FA. Clostridium perfringens type A enterotoxin damages the rabbit colon. Infection and Immunity. 82: 2211-8. PMID 24643537 DOI: 10.1128/IAI.01659-14  0.333
2013 Shrestha A, McClane BA. Human claudin-8 and -14 are receptors capable of conveying the cytotoxic effects of Clostridium perfringens enterotoxin. Mbio. 4. PMID 23322640 DOI: 10.1128/mBio.00594-12  0.301
2012 Chen J, Theoret JR, Shrestha A, Smedley JG, McClane BA. Cysteine-scanning mutagenesis supports the importance of Clostridium perfringens enterotoxin amino acids 80 to 106 for membrane insertion and pore formation. Infection and Immunity. 80: 4078-88. PMID 22966051 DOI: 10.1128/Iai.00069-12  0.728
2012 Gao Z, McClane BA. Use of Clostridium perfringens Enterotoxin and the Enterotoxin Receptor-Binding Domain (C-CPE) for Cancer Treatment: Opportunities and Challenges. Journal of Toxicology. 2012: 981626. PMID 21941545 DOI: 10.1155/2012/981626  0.365
2011 Briggs DC, Naylor CE, Smedley JG, Lukoyanova N, Robertson S, Moss DS, McClane BA, Basak AK. Structure of the food-poisoning Clostridium perfringens enterotoxin reveals similarity to the aerolysin-like pore-forming toxins. Journal of Molecular Biology. 413: 138-49. PMID 21839091 DOI: 10.1016/J.Jmb.2011.07.066  0.759
2011 Caserta JA, Robertson SL, Saputo J, Shrestha A, McClane BA, Uzal FA. Development and application of a mouse intestinal loop model to study the in vivo action of Clostridium perfringens enterotoxin. Infection and Immunity. 79: 3020-7. PMID 21628512 DOI: 10.1128/Iai.01342-10  0.739
2011 Gao Z, Xu X, McClane B, Zeng Q, Litkouhi B, Welch WR, Berkowitz RS, Mok SC, Garner EI. C terminus of Clostridium perfringens enterotoxin downregulates CLDN4 and sensitizes ovarian cancer cells to Taxol and Carboplatin. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 1065-74. PMID 21123456 DOI: 10.1158/1078-0432.Ccr-10-1644  0.396
2010 Briggs DC, Smedley JG, McClane BA, Basak AK. Crystallization and preliminary crystallographic analysis of the Clostridium perfringens enterotoxin. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 794-7. PMID 20606275 DOI: 10.1107/S1744309110016507  0.703
2010 Robertson SL, Smedley JG, McClane BA. Identification of a claudin-4 residue important for mediating the host cell binding and action of Clostridium perfringens enterotoxin. Infection and Immunity. 78: 505-17. PMID 19884339 DOI: 10.1128/Iai.00778-09  0.739
2008 Caserta JA, Hale ML, Popoff MR, Stiles BG, McClane BA. Evidence that membrane rafts are not required for the action of Clostridium perfringens enterotoxin. Infection and Immunity. 76: 5677-85. PMID 18809663 DOI: 10.1128/Iai.00854-08  0.744
2008 Smedley JG, Saputo J, Parker JC, Fernandez-Miyakawa ME, Robertson SL, McClane BA, Uzal FA. Noncytotoxic Clostridium perfringens enterotoxin (CPE) variants localize CPE intestinal binding and demonstrate a relationship between CPE-induced cytotoxicity and enterotoxicity. Infection and Immunity. 76: 3793-800. PMID 18505809 DOI: 10.1128/Iai.00460-08  0.738
2008 Van Itallie CM, Betts L, Smedley JG, McClane BA, Anderson JM. Structure of the claudin-binding domain of Clostridium perfringens enterotoxin. The Journal of Biological Chemistry. 283: 268-74. PMID 17977833 DOI: 10.1074/Jbc.M708066200  0.741
2007 Kominsky SL, Tyler B, Sosnowski J, Brady K, Doucet M, Nell D, Smedley JG, McClane B, Brem H, Sukumar S. Clostridium perfringens enterotoxin as a novel-targeted therapeutic for brain metastasis. Cancer Research. 67: 7977-82. PMID 17804705 DOI: 10.1158/0008-5472.Can-07-1314  0.7
2007 Robertson SL, Smedley JG, Singh U, Chakrabarti G, Van Itallie CM, Anderson JM, McClane BA. Compositional and stoichiometric analysis of Clostridium perfringens enterotoxin complexes in Caco-2 cells and claudin 4 fibroblast transfectants. Cellular Microbiology. 9: 2734-55. PMID 17587331 DOI: 10.1111/J.1462-5822.2007.00994.X  0.744
2007 Chen Y, Caruso L, McClane B, Fisher D, Gupta P. Disruption of a toxin gene by introduction of a foreign gene into the chromosome of Clostridium perfringens using targetron-induced mutagenesis. Plasmid. 58: 182-9. PMID 17553563 DOI: 10.1016/J.Plasmid.2007.04.002  0.31
2007 Litkouhi B, Kwong J, Lo CM, Smedley JG, McClane BA, Aponte M, Gao Z, Sarno JL, Hinners J, Welch WR, Berkowitz RS, Mok SC, Garner EI. Claudin-4 overexpression in epithelial ovarian cancer is associated with hypomethylation and is a potential target for modulation of tight junction barrier function using a C-terminal fragment of Clostridium perfringens enterotoxin. Neoplasia (New York, N.Y.). 9: 304-14. PMID 17460774 DOI: 10.1593/Neo.07118  0.709
2007 Smedley JG, Uzal FA, McClane BA. Identification of a prepore large-complex stage in the mechanism of action of Clostridium perfringens enterotoxin. Infection and Immunity. 75: 2381-90. PMID 17307943 DOI: 10.1128/Iai.01737-06  0.76
2005 Bos J, Smithee L, McClane B, Distefano RF, Uzal F, Songer JG, Mallonee S, Crutcher JM. Fatal necrotizing colitis following a foodborne outbreak of enterotoxigenic Clostridium perfringens type A infection. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 40: e78-83. PMID 15844055 DOI: 10.1086/429829  0.348
2004 McClane BA, Chakrabarti G. New insights into the cytotoxic mechanisms of Clostridium perfringens enterotoxin. Anaerobe. 10: 107-14. PMID 16701507 DOI: 10.1016/j.anaerobe.2003.11.004  0.38
2004 Smedley JG, McClane BA. Fine mapping of the N-terminal cytotoxicity region of Clostridium perfringens enterotoxin by site-directed mutagenesis. Infection and Immunity. 72: 6914-23. PMID 15557612 DOI: 10.1128/Iai.72.12.6914-6923.2004  0.754
2004 Smedley JG, Fisher DJ, Sayeed S, Chakrabarti G, McClane BA. The enteric toxins of Clostridium perfringens. Reviews of Physiology, Biochemistry and Pharmacology. 152: 183-204. PMID 15517462 DOI: 10.1007/S10254-004-0036-2  0.743
2001 McClane BA. The complex interactions between Clostridium perfringens enterotoxin and epithelial tight junctions. Toxicon : Official Journal of the International Society On Toxinology. 39: 1781-91. PMID 11595640 DOI: 10.1016/S0041-0101(01)00164-7  0.398
2001 Michl P, Buchholz M, Rolke M, Kunsch S, Löhr M, McClane B, Tsukita S, Leder G, Adler G, Gress TM. Claudin-4: a new target for pancreatic cancer treatment using Clostridium perfringens enterotoxin. Gastroenterology. 121: 678-84. PMID 11522752 DOI: 10.1053/Gast.2001.27124  0.3
2000 Singh U, Van Itallie CM, Mitic LL, Anderson JM, McClane BA. CaCo-2 cells treated with Clostridium perfringens enterotoxin form multiple large complex species, one of which contains the tight junction protein occludin. The Journal of Biological Chemistry. 275: 18407-17. PMID 10749869 DOI: 10.1074/jbc.M001530200  0.348
1999 Kokai-Kun JF, Benton K, Wieckowski EU, McClane BA. Identification of a Clostridium perfringens enterotoxin region required for large complex formation and cytotoxicity by random mutagenesis. Infection and Immunity. 67: 5634-41. PMID 10531210 DOI: 10.1128/iai.67.11.5634-5641.1999  0.398
1998 Wieckowski EU, Kokai-Kun JF, McClane BA. Characterization of membrane-associated Clostridium perfringens enterotoxin following pronase treatment. Infection and Immunity. 66: 5897-905. PMID 9826371 DOI: 10.1128/iai.66.12.5897-5905.1998  0.329
1997 Kokai-Kun JF, McClane BA. Deletion analysis of the Clostridium perfringens enterotoxin. Infection and Immunity. 65: 1014-22. PMID 9038311 DOI: 10.1128/iai.65.3.1014-1022.1997  0.329
1997 McClane BA. An overview of Clostridium perfringens enterotoxin. Toxicon : Official Journal of the International Society On Toxinology. 34: 1335-43. PMID 9027990 DOI: 10.1016/S0041-0101(96)00101-8  0.404
1990 McClane BA, Wnek AP. Studies of Clostridium perfringens enterotoxin action at different temperatures demonstrate a correlation between complex formation and cytotoxicity. Infection and Immunity. 58: 3109-15. PMID 2117579 DOI: 10.1128/iai.58.9.3109-3115.1990  0.339
1989 Hanna PC, Wnek AP, McClane BA. Molecular cloning of the 3' half of the Clostridium perfringens enterotoxin gene and demonstration that this region encodes receptor-binding activity Journal of Bacteriology. 171: 6815-6820. PMID 2556374 DOI: 10.1128/Jb.171.12.6815-6820.1989  0.336
1989 Wnek AP, McClane BA. Preliminary evidence that Clostridium perfringens type A enterotoxin is present in a 160,000-Mr complex in mammalian membranes. Infection and Immunity. 57: 574-81. PMID 2536357 DOI: 10.1128/iai.57.2.574-581.1989  0.313
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