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Shun Shimohama, MD, PhD - Publications

Affiliations: 
Neurology Sapporo Medical University, Sapporo-shi, Hokkaidō, Japan 
Website:
http://www.biomedexperts.com/Profile.bme/1298098/Shun_Shimohama

79 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Kuroda E, Nishimura K, Kawanishi S, Sueyoshi M, Ueno F, Toji Y, Abo N, Konishi T, Harada K, Satake S, Shima C, Toda Y, Kitamura Y, Shimohama S, Ashihara E, et al. Mouse Bone Marrow-derived Microglia-like Cells Secrete Transforming Growth Factor-β1 and Promote Microglial Aβ Phagocytosis and Reduction of Brain Aβ. Neuroscience. 438: 217-228. PMID 32522344 DOI: 10.1016/J.Neuroscience.2020.05.004  0.304
2017 Takata K, Amamiya T, Mizoguchi H, Kawanishi S, Kuroda E, Kitamura R, Ito A, Saito Y, Tawa M, Nagasawa T, Okamoto H, Sugino Y, Takegami S, Kitade T, Toda Y, ... ... Shimohama S, et al. Alpha7 nicotinic acetylcholine receptor-specific agonist DMXBA (GTS-21) attenuates Aβ accumulation through suppression of neuronal γ-secretase activity and promotion of microglial amyloid-β phagocytosis and ameliorates cognitive impairment in a mouse model of Alzheimer's disease. Neurobiology of Aging. 62: 197-209. PMID 29175709 DOI: 10.1016/J.Neurobiolaging.2017.10.021  0.341
2015 Watanabe K, Uemura K, Asada M, Maesako M, Akiyama H, Shimohama S, Takahashi R, Kinoshita A. The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer's disease. Molecular Brain. 8: 82. PMID 26637371 DOI: 10.1186/S13041-015-0174-2  0.345
2015 Kato T, Konishi Y, Shimohama S, Beach TG, Akatsu H, Tooyama I. Alpha1-chimaerin, a Rac1 GTPase-activating protein, is expressed at reduced mRNA levels in the brain of Alzheimer's disease patients. Neuroscience Letters. 591: 19-24. PMID 25676811 DOI: 10.1016/J.Neulet.2015.02.013  0.33
2015 Jingami N, Asada-Utsugi M, Uemura K, Noto R, Takahashi M, Ozaki A, Kihara T, Kageyama T, Takahashi R, Shimohama S, Kinoshita A. Idiopathic normal pressure hydrocephalus has a different cerebrospinal fluid biomarker profile from Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 45: 109-15. PMID 25428256 DOI: 10.3233/Jad-142622  0.322
2015 Matsumura A, Suzuki S, Iwahara N, Hisahara S, Kawamata J, Suzuki H, Yamauchi A, Takata K, Kitamura Y, Shimohama S. Temporal changes of CD68 and α7 nicotinic acetylcholine receptor expression in microglia in Alzheimer's disease-like mouse models. Journal of Alzheimer's Disease : Jad. 44: 409-23. PMID 25352454 DOI: 10.3233/Jad-141572  0.324
2013 Noda Y, Asada M, Kubota M, Maesako M, Watanabe K, Uemura M, Kihara T, Shimohama S, Takahashi R, Kinoshita A, Uemura K. Copper enhances APP dimerization and promotes Aβ production. Neuroscience Letters. 547: 10-5. PMID 23669644 DOI: 10.1016/J.Neulet.2013.04.057  0.311
2013 Suzuki S, Kawamata J, Matsushita T, Matsumura A, Hisahara S, Takata K, Kitamura Y, Kem W, Shimohama S. 3-[(2,4-Dimethoxy)benzylidene]-anabaseine dihydrochloride protects against 6-hydroxydopamine-induced parkinsonian neurodegeneration through α7 nicotinic acetylcholine receptor stimulation in rats. Journal of Neuroscience Research. 91: 462-71. PMID 23239187 DOI: 10.1002/Jnr.23160  0.321
2012 Takata K, Takada T, Ito A, Asai M, Tawa M, Saito Y, Ashihara E, Tomimoto H, Kitamura Y, Shimohama S. Microglial Amyloid-β1-40 Phagocytosis Dysfunction Is Caused by High-Mobility Group Box Protein-1: Implications for the Pathological Progression of Alzheimer's Disease. International Journal of Alzheimer's Disease. 2012: 685739. PMID 22645697 DOI: 10.1155/2012/685739  0.356
2012 Maesako M, Uemura K, Kubota M, Kuzuya A, Sasaki K, Asada M, Watanabe K, Hayashida N, Ihara M, Ito H, Shimohama S, Kihara T, Kinoshita A. Environmental enrichment ameliorated high-fat diet-induced Aβ deposition and memory deficit in APP transgenic mice. Neurobiology of Aging. 33: 1011.e11-23. PMID 22197104 DOI: 10.1016/J.Neurobiolaging.2011.10.028  0.309
2010 Takata K, Kitamura Y, Saeki M, Terada M, Kagitani S, Kitamura R, Fujikawa Y, Maelicke A, Tomimoto H, Taniguchi T, Shimohama S. Galantamine-induced amyloid-{beta} clearance mediated via stimulation of microglial nicotinic acetylcholine receptors. The Journal of Biological Chemistry. 285: 40180-91. PMID 20947502 DOI: 10.1074/Jbc.M110.142356  0.32
2010 Nunomura A, Tamaoki T, Tanaka K, Motohashi N, Nakamura M, Hayashi T, Yamaguchi H, Shimohama S, Lee HG, Zhu X, Smith MA, Perry G. Intraneuronal amyloid beta accumulation and oxidative damage to nucleic acids in Alzheimer disease. Neurobiology of Disease. 37: 731-7. PMID 20034567 DOI: 10.1016/J.Nbd.2009.12.012  0.547
2009 Takata K, Kitamura Y, Nakata Y, Matsuoka Y, Tomimoto H, Taniguchi T, Shimohama S. Involvement of WAVE accumulation in Abeta/APP pathology-dependent tangle modification in Alzheimer's disease. The American Journal of Pathology. 175: 17-24. PMID 19497998 DOI: 10.2353/Ajpath.2009.080908  0.327
2008 Zhu X, Wang Y, Ogawa O, Lee HG, Raina AK, Fujioka H, Shimohama S, Atwood CS, Petersen RB, Perry G, Smith MA. Oral Presentations OP01: Neurodegenerative Diseases Journal of Neurochemistry. 81: 76-76. DOI: 10.1046/J.1471-4159.81.S1.44_1.X  0.556
2006 Tsuchiya D, Kitamura Y, Takata K, Taniguchi T, Uemura K, Miki H, Takenawa T, Shimohama S. Morphological change by overexpression of D385A dominant negative presenilin 1 in human neuroblastoma SH-SY5Y cells. Journal of Pharmacological Sciences. 102: 354-8. PMID 17099291 DOI: 10.1254/Jphs.Sc0060118  0.317
2006 Akatsu H, Yamagata HD, Kawamata J, Kamino K, Takeda M, Yamamoto T, Miki T, Tooyama I, Shimohama S, Kosaka K. Variations in the BDNF gene in autopsy-confirmed Alzheimer's disease and dementia with Lewy bodies in Japan. Dementia and Geriatric Cognitive Disorders. 22: 216-22. PMID 16899999 DOI: 10.1159/000094933  0.304
2005 Honda K, Smith MA, Zhu X, Baus D, Merrick WC, Tartakoff AM, Hattier T, Harris PL, Siedlak SL, Fujioka H, Liu Q, Moreira PI, Miller FP, Nunomura A, Shimohama S, et al. Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron. The Journal of Biological Chemistry. 280: 20978-86. PMID 15767256 DOI: 10.1074/Jbc.M500526200  0.509
2005 Liu Q, Smith MA, Avilá J, DeBernardis J, Kansal M, Takeda A, Zhu X, Nunomura A, Honda K, Moreira PI, Oliveira CR, Santos MS, Shimohama S, Aliev G, de la Torre J, et al. Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations. Free Radical Biology & Medicine. 38: 746-54. PMID 15721985 DOI: 10.1016/J.Freeradbiomed.2004.11.005  0.531
2005 Inden M, Kondo J, Kitamura Y, Takata K, Nishimura K, Taniguchi T, Sawada H, Shimohama S. Proteasome inhibitors protect against degeneration of nigral dopaminergic neurons in hemiparkinsonian rats. Journal of Pharmacological Sciences. 97: 203-11. PMID 15684568 DOI: 10.1254/Jphs.Fp0040525  0.311
2004 Kihara T, Sawada H, Nakamizo T, Kanki R, Yamashita H, Maelicke A, Shimohama S. Galantamine modulates nicotinic receptor and blocks Abeta-enhanced glutamate toxicity. Biochemical and Biophysical Research Communications. 325: 976-82. PMID 15541385 DOI: 10.1016/J.Bbrc.2004.10.132  0.309
2004 Zhu X, Wang Y, Ogawa O, Lee HG, Raina AK, Siedlak SL, Harris PL, Fujioka H, Shimohama S, Tabaton M, Atwood CS, Petersen RB, Perry G, Smith MA. Neuroprotective properties of Bcl-w in Alzheimer disease. Journal of Neurochemistry. 89: 1233-40. PMID 15147516 DOI: 10.1111/J.1471-4159.2004.02416.X  0.559
2003 Raina AK, Zhu X, Shimohama S, Perry G, Smith MA. Tipping the apoptotic balance in Alzheimer's disease: the abortosis concept. Cell Biochemistry and Biophysics. 39: 249-55. PMID 14716079 DOI: 10.1385/Cbb:39:3:249  0.534
2003 Kitamura Y, Tsuchiya D, Takata K, Shibagaki K, Taniguchi T, Smith MA, Perry G, Miki H, Takenawa T, Shimohama S. Possible involvement of Wiskott-Aldrich syndrome protein family in aberrant neuronal sprouting in Alzheimer's disease. Neuroscience Letters. 346: 149-52. PMID 12853106 DOI: 10.1016/S0304-3940(03)00506-8  0.551
2003 Raina AK, Hochman A, Ickes H, Zhu X, Ogawa O, Cash AD, Shimohama S, Perry G, Smith MA. Apoptotic promoters and inhibitors in Alzheimer's disease: Who wins out? Progress in Neuro-Psychopharmacology & Biological Psychiatry. 27: 251-4. PMID 12657364 DOI: 10.1016/S0278-5846(03)00020-4  0.554
2003 Takata K, Kitamura Y, Kakimura J, Shibagaki K, Tsuchiya D, Taniguchi T, Smith MA, Perry G, Shimohama S. Role of high mobility group protein-1 (HMG1) in amyloid-beta homeostasis. Biochemical and Biophysical Research Communications. 301: 699-703. PMID 12565837 DOI: 10.1016/S0006-291X(03)00024-X  0.531
2002 Kakimura JI, Kitamura Y, Takata K, Umeki M, Suzuki S, Shibagaki K, Taniguchi T, Nomura Y, Gebicke-Haerter PJ, Smith MA, Perry G, Shimohama S. Microglial activation and amyloid-β clearance induced by exogenous heat-shock proteins. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 16: 601-603. PMID 29470936 DOI: 10.1096/fj.01-0530fje  0.35
2002 Takata K, Kitamura Y, Kakimura J, Shibagaki K, Taniguchi T, Gebicke-Haerter PJ, Smith MA, Perry G, Shimohama S. Possible protective mechanisms of heme oxygenase-1 in the brain. Annals of the New York Academy of Sciences. 977: 501-6. PMID 12480792 DOI: 10.1111/J.1749-6632.2002.Tb04857.X  0.496
2002 Kakimura J, Kitamura Y, Takata K, Tsuchiya D, Taniguchi T, Gebicke-Haerter PJ, Smith MA, Perry G, Shimohama S. Possible involvement of ER chaperone Grp78 on reduced formation of amyloid-beta deposits. Annals of the New York Academy of Sciences. 977: 327-32. PMID 12480769 DOI: 10.1111/J.1749-6632.2002.Tb04834.X  0.505
2002 Perry G, Taddeo MA, Nunomura A, Zhu X, Zenteno-Savin T, Drew KL, Shimohama S, Avila J, Castellani RJ, Smith MA. Comparative biology and pathology of oxidative stress in Alzheimer and other neurodegenerative diseases: beyond damage and response. Comparative Biochemistry and Physiology. Toxicology & Pharmacology : Cbp. 133: 507-13. PMID 12458179 DOI: 10.1016/S1532-0456(02)00119-9  0.523
2002 Perry G, Nunomura A, Cash AD, Taddeo MA, Hirai K, Aliev G, Avila J, Wataya T, Shimohama S, Atwood CS, Smith MA. Reactive oxygen: its sources and significance in Alzheimer disease. Journal of Neural Transmission. Supplementum. 69-75. PMID 12456052 DOI: 10.1007/978-3-7091-6139-5_7  0.52
2002 Kihara T, Shimohama S, Sawada H, Honda K, Nakamizo T, Kanki R, Yamashita H, Akaike A. Protective effect of dopamine D2 agonists in cortical neurons via the phosphatidylinositol 3 kinase cascade. Journal of Neuroscience Research. 70: 274-82. PMID 12391586 DOI: 10.1002/Jnr.10426  0.327
2002 Sawada H, Ibi M, Kihara T, Honda K, Nakamizo T, Kanki R, Nakanishi M, Sakka N, Akaike A, Shimohama S. Estradiol protects dopaminergic neurons in a MPP+Parkinson's disease model. Neuropharmacology. 42: 1056-64. PMID 12128007 DOI: 10.1016/S0028-3908(02)00049-7  0.321
2002 Kakimura J, Kitamura Y, Takata K, Umeki M, Suzuki S, Shibagaki K, Taniguchi T, Nomura Y, Gebicke-Haerter PJ, Smith MA, Perry G, Shimohama S. Microglial activation and amyloid-beta clearance induced by exogenous heat-shock proteins. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 16: 601-3. PMID 11919167 DOI: 10.1096/Fj.01-0530Fje  0.533
2002 Kume T, Asai N, Nishikawa H, Mano N, Terauchi T, Taguchi R, Shirakawa H, Osakada F, Mori H, Asakawa N, Yonaga M, Nishizawa Y, Sugimoto H, Shimohama S, Katsuki H, et al. Isolation of a diterpenoid substance with potent neuroprotective activity from fetal calf serum. Proceedings of the National Academy of Sciences of the United States of America. 99: 3288-93. PMID 11867740 DOI: 10.1073/Pnas.052693999  0.301
2002 Castellani RJ, Perry G, Siedlak SL, Nunomura A, Shimohama S, Zhang J, Montine T, Sayre LM, Smith MA. Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans. Neuroscience Letters. 319: 25-8. PMID 11814645 DOI: 10.1016/S0304-3940(01)02514-9  0.5
2002 Wataya T, Nunomura A, Smith MA, Siedlak SL, Harris PL, Shimohama S, Szweda LI, Kaminski MA, Avila J, Price DL, Cleveland DW, Sayre LM, Perry G. High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal. The Journal of Biological Chemistry. 277: 4644-8. PMID 11733539 DOI: 10.1074/Jbc.M110913200  0.51
2001 Zhu X, Rottkamp CA, Hartzler A, Sun Z, Takeda A, Boux H, Shimohama S, Perry G, Smith MA. Activation of MKK6, an upstream activator of p38, in Alzheimer's disease. Journal of Neurochemistry. 79: 311-8. PMID 11677259 DOI: 10.1046/J.1471-4159.2001.00597.X  0.463
2001 Nunomura A, Perry G, Aliev G, Hirai K, Takeda A, Balraj EK, Jones PK, Ghanbari H, Wataya T, Shimohama S, Chiba S, Atwood CS, Petersen RB, Smith MA. Oxidative damage is the earliest event in Alzheimer disease. Journal of Neuropathology and Experimental Neurology. 60: 759-67. PMID 11487050 DOI: 10.1093/Jnen/60.8.759  0.553
2001 Honda K, Shimohama S, Sawada H, Kihara T, Nakamizo T, Shibasaki H, Akaike A. Nongenomic antiapoptotic signal transduction by estrogen in cultured cortical neurons. Journal of Neuroscience Research. 64: 466-75. PMID 11391701 DOI: 10.1002/Jnr.1098  0.308
2001 Hirai K, Aliev G, Nunomura A, Fujioka H, Russell RL, Atwood CS, Johnson AB, Kress Y, Vinters HV, Tabaton M, Shimohama S, Cash AD, Siedlak SL, Harris PL, Jones PK, et al. Mitochondrial abnormalities in Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 3017-23. PMID 11312286  0.366
2001 Kitamura Y, Ishida Y, Takata K, Kakimura J, Mizutani H, Shimohama S, Akaike A, Taniguchi T. Alpha-synuclein protein is not scavenged in neuronal loss induced by kainic acid or focal ischemia. Brain Research. 898: 181-5. PMID 11292464 DOI: 10.1016/S0006-8993(01)02159-X  0.304
2001 Hirai K, Aliev G, Nunomura A, Fujioka H, Russell RL, Atwood CS, Johnson AB, Kress Y, Vinters HV, Tabaton M, Shimohama S, Cash AD, Siedlak SL, Harris PLR, Jones PK, et al. Mitochondrial Abnormalities in Alzheimer's Disease The Journal of Neuroscience. 21: 3017-3023. DOI: 10.1523/Jneurosci.21-09-03017.2001  0.45
2000 Kim HT, Russell RL, Raina AK, Harris PL, Siedlak SL, Zhu X, Petersen RB, Shimohama S, Smith MA, Perry G. Protein disulfide isomerase in Alzheimer disease. Antioxidants & Redox Signaling. 2: 485-9. PMID 11229362 DOI: 10.1089/15230860050192260  0.556
2000 Shimohama S, Tanino H, Kawakami N, Okamura N, Kodama H, Yamaguchi T, Hayakawa T, Nunomura A, Chiba S, Perry G, Smith MA, Fujimoto S. Activation of NADPH oxidase in Alzheimer's disease brains. Biochemical and Biophysical Research Communications. 273: 5-9. PMID 10873554 DOI: 10.1006/Bbrc.2000.2897  0.554
2000 Honda K, Sawada H, Kihara T, Urushitani M, Nakamizo T, Akaike A, Shimohama S. Phosphatidylinositol 3-kinase mediates neuroprotection by estrogen in cultured cortical neurons. Journal of Neuroscience Research. 60: 321-7. PMID 10797534 DOI: 10.1002/(Sici)1097-4547(20000501)60:3<321::Aid-Jnr6>3.0.Co;2-T  0.308
1999 Imura T, Shimohama S, Sato M, Nishikawa H, Madono K, Akaike A, Kimura J. Differential Expression of Small Heat Shock Proteins in Reactive Astrocytes after Focal Ischemia: Possible Role of β-Adrenergic Receptor The Journal of Neuroscience. 19: 9768-9779. DOI: 10.1523/Jneurosci.19-22-09768.1999  0.301
1998 Hattori N, Kitagawa K, Higashida T, Yagyu K, Shimohama S, Wataya T, Perry G, Smith MA, Inagaki C. CI-ATPase and Na+/K(+)-ATPase activities in Alzheimer's disease brains. Neuroscience Letters. 254: 141-4. PMID 10214977 DOI: 10.1016/S0304-3940(98)00654-5  0.522
1998 Shimohama S, Kamiya S, Taniguchi T, Kimura J. Intracellular receptors for activated C-kinase in the postmortem human brain: no alteration in Alzheimer disease. Alzheimer Disease and Associated Disorders. 12: 384-6. PMID 9876970 DOI: 10.1097/00002093-199812000-00022  0.346
1998 Matsushima H, Shimohama S, Kawamata J, Fujimoto S, Takenawa T, Kimura J. Reduction of platelet phospholipase C-delta1 activity in Alzheimer's disease associated with a specific apolipoprotein E genotype (epsilon3/epsilon3). International Journal of Molecular Medicine. 1: 91-3. PMID 9852204 DOI: 10.3892/Ijmm.1.1.91  0.311
1998 Tsuji T, Shimohama S, Kimura J, Shimizu K. m-Calpain (calcium-activated neutral proteinase) in Alzheimer's disease brains. Neuroscience Letters. 248: 109-12. PMID 9654354 DOI: 10.1016/S0304-3940(98)00348-6  0.317
1998 Kitamura Y, Shimohama S, Kamoshima W, Ota T, Matsuoka Y, Nomura Y, Smith MA, Perry G, Whitehouse PJ, Taniguchi T. Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32, in Alzheimer's disease. Brain Research. 780: 260-9. PMID 9507158 DOI: 10.1016/S0006-8993(97)01202-X  0.538
1998 Shimohama S, Sasaki Y, Fujimoto S, Kamiya S, Taniguchi T, Takenawa T, Kimura J. Phospholipase C isozymes in the human brain and their changes in Alzheimer's disease. Neuroscience. 82: 999-1007. PMID 9466424 DOI: 10.1016/S0306-4522(97)00342-4  0.305
1997 Kaneko S, Maeda T, Kume T, Kochiyama H, Akaike A, Shimohama S, Kimura J. Nicotine protects cultured cortical neurons against glutamate-induced cytotoxicity via alpha7-neuronal receptors and neuronal CNS receptors. Brain Research. 765: 135-40. PMID 9310404 DOI: 10.1016/S0006-8993(97)00556-8  0.3
1997 Kihara T, Shimohama S, Sawada H, Kimura J, Kume T, Kochiyama H, Maeda T, Akaike A. Nicotinic receptor stimulation protects neurons against beta-amyloid toxicity. Annals of Neurology. 42: 159-63. PMID 9266724 DOI: 10.1002/Ana.410420205  0.309
1997 Shimohama S, Kamiya S, Taniguchi T, Akagawa K, Kimura J. Differential involvement of synaptic vesicle and presynaptic plasma membrane proteins in Alzheimer's disease. Biochemical and Biophysical Research Communications. 236: 239-42. PMID 9240416 DOI: 10.1006/Bbrc.1997.6940  0.307
1997 Kume T, Kouchiyama H, Kaneko S, Maeda T, Kaneko S, Akaike A, Shimohama S, Kihara T, Kimura J, Wada K, Koizumi S. BDNF prevents NO mediated glutamate cytotoxicity in cultured cortical neurons. Brain Research. 756: 200-4. PMID 9187333 DOI: 10.1016/S0006-8993(97)00195-9  0.301
1997 Matsuoka Y, Kitamura Y, Fukunaga R, Shimohama S, Nabeshima T, Tooyama I, Kimura H, Taniguchi T. In vivo hypoxia-induced neuronal damage in dentate gyrus of rat hippocampus: changes in NMDA receptors and the effect of MK-801. Neurochemistry International. 30: 533-42. PMID 9152994 DOI: 10.1016/S0197-0186(96)00125-8  0.306
1996 Sawada H, Shimohama S, Kawamura T, Akaike A, Kitamura Y, Taniguchi T, Kimura J. Mechanism of resistance to NO-induced neurotoxicity in cultured rat dopaminergic neurons. Journal of Neuroscience Research. 46: 509-18. PMID 8950711 DOI: 10.1002/(Sici)1097-4547(19961115)46:4<509::Aid-Jnr13>3.0.Co;2-T  0.311
1996 Sawada H, Shimohama S, Tamura Y, Kawamura T, Akaike A, Kimura J. Methylphenylpyridium ion (MPP+) enhances glutamate-induced cytotoxicity against dopaminergic neurons in cultured rat mesencephalon. Journal of Neuroscience Research. 43: 55-62. PMID 8838574 DOI: 10.1002/Jnr.490430107  0.318
1996 Shimohama S, Chachin M, Taniguchi T, Hidaka H, Kimura J. Changes of neurocalcin, a calcium-binding protein, in the brain of patients with Alzheimer's disease. Brain Research. 716: 233-6. PMID 8738246 DOI: 10.1016/0006-8993(96)00070-4  0.334
1996 Sawada H, Kawamura T, Shimohama S, Akaike A, Kimura J. Different mechanisms of glutamate-induced neuronal death between dopaminergic and non-dopaminergic neurons in rat mesencephalic culture. Journal of Neuroscience Research. 43: 503-10. PMID 8699537 DOI: 10.1002/(Sici)1097-4547(19960215)43:4<503::Aid-Jnr12>3.0.Co;2-2  0.312
1995 Matsushima H, Shimohama S, Fujimoto S, Takenawa T, Kimura J. Changes in platelet phospholipase C protein level and activity in Alzheimer's disease. Neurobiology of Aging. 16: 895-900. PMID 8622779 DOI: 10.1016/0197-4580(95)02003-9  0.334
1995 Shimohama S, Fujimoto S, Chachin M, Taniguchi T, Perry G, Whitehouse PJ, Kimura J. Alterations of low molecular weight acid phosphatase protein level in Alzheimer's disease. Brain Research. 699: 125-9. PMID 8616601 DOI: 10.1016/0006-8993(95)00995-3  0.449
1995 Shimohama S, Fujimoto S, Matsushima H, Takenawa T, Taniguchi T, Perry G, Whitehouse PJ, Kimura J. Alteration of phospholipase C-delta protein level and specific activity in Alzheimer's disease. Journal of Neurochemistry. 64: 2629-34. PMID 7760043 DOI: 10.1046/J.1471-4159.1995.64062629.X  0.467
1995 Shimohama S, Perry G, Richey P, Praprotnik D, Takenawa T, Fukami K, Whitehouse PJ, Kimura J. Characterization of the association of phospholipase C-delta with Alzheimer neurofibrillary tangles. Brain Research. 669: 217-24. PMID 7712177 DOI: 10.1016/0006-8993(94)01239-E  0.451
1995 Shimohama S, Akaike A, Tamura Y, Matsushima H, Kume T, Fujimoto S, Takenawa T, Kimura J. Glutamate-induced antigenic changes of phospholipase C-delta in cultured cortical neurons. Journal of Neuroscience Research. 41: 418-26. PMID 7563235 DOI: 10.1002/Jnr.490410315  0.335
1995 Matsushima H, Shimohama S, Fujimoto S, Takenawa T, Kimura J. Reduction of platelet phospholipase C activity in patients with Alzheimer disease. Alzheimer Disease & Associated Disorders. 9: 213-217. DOI: 10.1097/00002093-199500940-00007  0.343
1994 Kawamata J, Tanaka S, Shimohama S, Ueda K, Kimura J. Apolipoprotein E polymorphism in Japanese patients with Alzheimer's disease or vascular dementia. Journal of Neurology, Neurosurgery, and Psychiatry. 57: 1414-6. PMID 7964823 DOI: 10.1136/Jnnp.57.11.1414  0.312
1994 Matsushima H, Shimohama S, Tanaka S, Taniguchi T, Hagiwara M, Hidaka H, Kimura J. Platelet protein kinase C levels in Alzheimer's disease. Neurobiology of Aging. 15: 671-4. PMID 7891820 DOI: 10.1016/0197-4580(94)90047-7  0.331
1993 Shimohama S, Narita M, Matsushima H, Kimura J, Kameyama M, Hagiwara M, Hidaka H, Taniguchi T. Assessment of protein kinase C isozymes by two-site enzyme immunoassay in human brains and changes in Alzheimer's disease. Neurology. 43: 1407-13. PMID 8327146 DOI: 10.1212/Wnl.43.7.1407  0.323
1993 Shimohama S, Fujimoto S, Tresser N, Richey P, Perry G, Whitehouse PJ, Homma Y, Takenawa T, Taniguchi T, Suenaga T. Aberrant phosphoinositide metabolism in Alzheimer's disease. Annals of the New York Academy of Sciences. 695: 46-9. PMID 8239311 DOI: 10.1111/J.1749-6632.1993.Tb23025.X  0.48
1993 Shimohama S, Perry G, Richey P, Takenawa T, Whitehouse PJ, Miyoshi K, Suenaga T, Matsumoto S, Nishimura M, Kimura J. Abnormal accumulation of phospholipase C-delta in filamentous inclusions of human neurodegenerative diseases. Neuroscience Letters. 162: 183-6. PMID 8121625 DOI: 10.1016/0304-3940(93)90591-8  0.461
1993 Shimohama S, Tamura Y, Akaike A, Tsukahara T, Ohara O, Watanabe S, Kimura J. Brain-derived neurotrophic factor pretreatment exerts a partially protective effect against glutamate-induced neurotoxicity in cultured rat cortical neurons. Neuroscience Letters. 164: 55-8. PMID 7908729 DOI: 10.1016/0304-3940(93)90856-G  0.302
1992 Shimohama S, Fujimoto S, Taniguchi T, Kimura J. Phosphatidylinositol-specific phospholipase C activity in the postmortem human brain: no alteration in Alzheimer's disease. Brain Research. 579: 347-9. PMID 1628221 DOI: 10.1016/0006-8993(92)90073-I  0.326
1991 Araki W, Kitaguchi N, Tokushima Y, Ishii K, Aratake H, Shimohama S, Nakamura S, Kimura J. Trophic effect of beta-amyloid precursor protein on cerebral cortical neurons in culture. Biochemical and Biophysical Research Communications. 181: 265-71. PMID 1958195 DOI: 10.1016/S0006-291X(05)81412-3  0.335
1991 Shimohama S, Suenaga T, Araki W, Yamaoaka Y, Shimizu K, Kimura J. Presence of calpain II immunoreactivity in senile plaques in Alzheimer's disease. Brain Research. 558: 105-8. PMID 1718565 DOI: 10.1016/0006-8993(91)90722-8  0.336
1991 Shimohama S, Uehara-Kunugi Y, Terai K, Taniguchi T, Kimura J, Saitoh T. Expression of protein kinase C isozymes in primary neuronal cultures of the rat cerebellum. Journal of Neuroscience Research. 29: 261-70. PMID 1716324 DOI: 10.1002/Jnr.490290217  0.311
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