| Year |
Citation |
Score |
| 2020 |
Kuroda E, Nishimura K, Kawanishi S, Sueyoshi M, Ueno F, Toji Y, Abo N, Konishi T, Harada K, Satake S, Shima C, Toda Y, Kitamura Y, Shimohama S, Ashihara E, et al. Mouse Bone Marrow-derived Microglia-like Cells Secrete Transforming Growth Factor-β1 and Promote Microglial Aβ Phagocytosis and Reduction of Brain Aβ. Neuroscience. 438: 217-228. PMID 32522344 DOI: 10.1016/J.Neuroscience.2020.05.004 |
0.324 |
|
| 2019 |
Yokokawa K, Iwahara N, Hisahara S, Emoto MC, Saito T, Suzuki H, Manabe T, Matsumura A, Matsushita T, Suzuki S, Kawamata J, Sato-Akaba H, Fujii HG, Shimohama S. Transplantation of Mesenchymal Stem Cells Improves Amyloid-β Pathology by Modifying Microglial Function and Suppressing Oxidative Stress. Journal of Alzheimer's Disease : Jad. PMID 31640102 DOI: 10.3233/Jad-190817 |
0.336 |
|
| 2019 |
Saito T, Hisahara S, Iwahara N, Emoto MC, Yokokawa K, Suzuki H, Manabe T, Matsumura A, Suzuki S, Matsushita T, Kawamata J, Sato-Akaba H, Fujii HG, Shimohama S. Early administration of galantamine from preplaque phase suppresses oxidative stress and improves cognitive behavior in APPswe/PS1dE9 mouse model of Alzheimer's disease. Free Radical Biology & Medicine. 145: 20-32. PMID 31536772 DOI: 10.1016/J.Freeradbiomed.2019.09.014 |
0.373 |
|
| 2019 |
Manabe T, Matsumura A, Yokokawa K, Saito T, Fujikura M, Iwahara N, Matsushita T, Suzuki S, Hisahara S, Kawamata J, Suzuki H, Emoto MC, Fujii HG, Shimohama S. Evaluation of Mitochondrial Oxidative Stress in the Brain of a Transgenic Mouse Model of Alzheimer's Disease by in vitro Electron Paramagnetic Resonance Spectroscopy. Journal of Alzheimer's Disease : Jad. PMID 30714961 DOI: 10.3233/Jad-180985 |
0.364 |
|
| 2017 |
Takata K, Amamiya T, Mizoguchi H, Kawanishi S, Kuroda E, Kitamura R, Ito A, Saito Y, Tawa M, Nagasawa T, Okamoto H, Sugino Y, Takegami S, Kitade T, Toda Y, ... ... Shimohama S, et al. Alpha7 nicotinic acetylcholine receptor-specific agonist DMXBA (GTS-21) attenuates Aβ accumulation through suppression of neuronal γ-secretase activity and promotion of microglial amyloid-β phagocytosis and ameliorates cognitive impairment in a mouse model of Alzheimer's disease. Neurobiology of Aging. 62: 197-209. PMID 29175709 DOI: 10.1016/J.Neurobiolaging.2017.10.021 |
0.382 |
|
| 2016 |
Kitamura Y, Inden M, Kimoto Y, Takata K, Yanagisawa D, Hijioka M, Ashihara E, Tooyama I, Shimohama S, Ariga H. Effects of a DJ-1-Binding Compound on Spatial Learning and Memory Impairment in a Mouse Model of Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 27662308 DOI: 10.3233/Jad-160574 |
0.315 |
|
| 2015 |
Watanabe K, Uemura K, Asada M, Maesako M, Akiyama H, Shimohama S, Takahashi R, Kinoshita A. The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer's disease. Molecular Brain. 8: 82. PMID 26637371 DOI: 10.1186/S13041-015-0174-2 |
0.38 |
|
| 2015 |
Maesako M, Uemura M, Tashiro Y, Sasaki K, Watanabe K, Noda Y, Ueda K, Asada-Utsugi M, Kubota M, Okawa K, Ihara M, Shimohama S, Uemura K, Kinoshita A. High Fat Diet Enhances β-Site Cleavage of Amyloid Precursor Protein (APP) via Promoting β-Site APP Cleaving Enzyme 1/Adaptor Protein 2/Clathrin Complex Formation. Plos One. 10: e0131199. PMID 26414661 DOI: 10.1371/Journal.Pone.0131199 |
0.31 |
|
| 2015 |
Matsumura A, Emoto MC, Suzuki S, Iwahara N, Hisahara S, Kawamata J, Suzuki H, Yamauchi A, Sato-Akaba H, Fujii HG, Shimohama S. Evaluation of oxidative stress in the brain of a transgenic mouse model of Alzheimer disease by in vivo electron paramagnetic resonance imaging. Free Radical Biology & Medicine. 85: 165-73. PMID 25912481 DOI: 10.1016/J.Freeradbiomed.2015.04.013 |
0.358 |
|
| 2015 |
Shimohama S. [Current concepts regarding cortical dementia]. Brain and Nerve = Shinkei Kenkyū No Shinpo. 67: 389-402. PMID 25846588 DOI: 10.11477/Mf.1416200155 |
0.309 |
|
| 2015 |
Kato T, Konishi Y, Shimohama S, Beach TG, Akatsu H, Tooyama I. Alpha1-chimaerin, a Rac1 GTPase-activating protein, is expressed at reduced mRNA levels in the brain of Alzheimer's disease patients. Neuroscience Letters. 591: 19-24. PMID 25676811 DOI: 10.1016/J.Neulet.2015.02.013 |
0.36 |
|
| 2015 |
Jingami N, Asada-Utsugi M, Uemura K, Noto R, Takahashi M, Ozaki A, Kihara T, Kageyama T, Takahashi R, Shimohama S, Kinoshita A. Idiopathic normal pressure hydrocephalus has a different cerebrospinal fluid biomarker profile from Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 45: 109-15. PMID 25428256 DOI: 10.3233/Jad-142622 |
0.34 |
|
| 2015 |
Matsumura A, Suzuki S, Iwahara N, Hisahara S, Kawamata J, Suzuki H, Yamauchi A, Takata K, Kitamura Y, Shimohama S. Temporal changes of CD68 and α7 nicotinic acetylcholine receptor expression in microglia in Alzheimer's disease-like mouse models. Journal of Alzheimer's Disease : Jad. 44: 409-23. PMID 25352454 DOI: 10.3233/Jad-141572 |
0.35 |
|
| 2013 |
Shimohama S. [Development of therapies for Alzheimer's disease based on cholinergic hypothesis-status quo and future directions]. Rinshå Shinkeigaku = Clinical Neurology. 53: 1036-8. PMID 24291871 DOI: 10.5692/Clinicalneurol.53.1036 |
0.357 |
|
| 2013 |
Noda Y, Asada M, Kubota M, Maesako M, Watanabe K, Uemura M, Kihara T, Shimohama S, Takahashi R, Kinoshita A, Uemura K. Copper enhances APP dimerization and promotes Aβ production. Neuroscience Letters. 547: 10-5. PMID 23669644 DOI: 10.1016/J.Neulet.2013.04.057 |
0.326 |
|
| 2013 |
Suzuki S, Kawamata J, Matsushita T, Matsumura A, Hisahara S, Takata K, Kitamura Y, Kem W, Shimohama S. 3-[(2,4-Dimethoxy)benzylidene]-anabaseine dihydrochloride protects against 6-hydroxydopamine-induced parkinsonian neurodegeneration through α7 nicotinic acetylcholine receptor stimulation in rats. Journal of Neuroscience Research. 91: 462-71. PMID 23239187 DOI: 10.1002/Jnr.23160 |
0.358 |
|
| 2013 |
Watanabe K, Uemura K, Asada M, Kubota M, Shimohama S, Takahashi R, Kinoshita A. The relationship between IGFBP released from astrocyte and Alzheimer's disease Alzheimers & Dementia. 9: 180. DOI: 10.1016/J.Jalz.2013.05.296 |
0.307 |
|
| 2012 |
Takata K, Takada T, Ito A, Asai M, Tawa M, Saito Y, Ashihara E, Tomimoto H, Kitamura Y, Shimohama S. Microglial Amyloid-β1-40 Phagocytosis Dysfunction Is Caused by High-Mobility Group Box Protein-1: Implications for the Pathological Progression of Alzheimer's Disease. International Journal of Alzheimer's Disease. 2012: 685739. PMID 22645697 DOI: 10.1155/2012/685739 |
0.399 |
|
| 2012 |
Maesako M, Uemura K, Kuzuya A, Sasaki K, Asada M, Watanabe K, Ando K, Kubota M, Akiyama H, Takahashi R, Kihara T, Shimohama S, Kinoshita A. Gain of function by phosphorylation in Presenilin 1-mediated regulation of insulin signaling. Journal of Neurochemistry. 121: 964-73. PMID 22443192 DOI: 10.1111/J.1471-4159.2012.07741.X |
0.302 |
|
| 2012 |
Kawamata J, Suzuki S, Shimohama S. α7 nicotinic acetylcholine receptor mediated neuroprotection in Parkinson's disease. Current Drug Targets. 13: 623-30. PMID 22300030 DOI: 10.2174/138945012800399026 |
0.304 |
|
| 2012 |
Maesako M, Uemura K, Kubota M, Kuzuya A, Sasaki K, Asada M, Watanabe K, Hayashida N, Ihara M, Ito H, Shimohama S, Kihara T, Kinoshita A. Environmental enrichment ameliorated high-fat diet-induced Aβ deposition and memory deficit in APP transgenic mice. Neurobiology of Aging. 33: 1011.e11-23. PMID 22197104 DOI: 10.1016/J.Neurobiolaging.2011.10.028 |
0.322 |
|
| 2011 |
Kawamata J, Suzuki S, Shimohama S. Enhancement of nicotinic receptors alleviates cytotoxicity in neurological disease models. Therapeutic Advances in Chronic Disease. 2: 197-208. PMID 23251750 DOI: 10.1177/2040622310397691 |
0.358 |
|
| 2011 |
Kawamata J, Shimohama S. Stimulating nicotinic receptors trigger multiple pathways attenuating cytotoxicity in models of Alzheimer's and Parkinson's diseases. Journal of Alzheimer's Disease : Jad. 24: 95-109. PMID 21403387 DOI: 10.3233/Jad-2011-110173 |
0.346 |
|
| 2011 |
Ando K, Uemura K, Kuzuya A, Maesako M, Asada-Utsugi M, Kubota M, Aoyagi N, Yoshioka K, Okawa K, Inoue H, Kawamata J, Shimohama S, Arai T, Takahashi R, Kinoshita A. N-cadherin regulates p38 MAPK signaling via association with JNK-associated leucine zipper protein: implications for neurodegeneration in Alzheimer disease. The Journal of Biological Chemistry. 286: 7619-28. PMID 21177868 DOI: 10.1074/Jbc.M110.158477 |
0.344 |
|
| 2011 |
Takata K, Takada T, Tatsuda H, Tsuruno T, Nishimura K, Shimohama S, Kitamura Y. Preparation and Characterization of Microglia-Like Cells Derived from Rat, Mouse, and Human Bone Marrow Cells for Therapeutic Strategy of Alzheimer's Disease Journal of Addiction Research and Therapy. 2013: 2-10. DOI: 10.4172/2155-6105.S5-001 |
0.324 |
|
| 2010 |
Takata K, Kitamura Y, Saeki M, Terada M, Kagitani S, Kitamura R, Fujikawa Y, Maelicke A, Tomimoto H, Taniguchi T, Shimohama S. Galantamine-induced amyloid-{beta} clearance mediated via stimulation of microglial nicotinic acetylcholine receptors. The Journal of Biological Chemistry. 285: 40180-91. PMID 20947502 DOI: 10.1074/Jbc.M110.142356 |
0.352 |
|
| 2010 |
Shen H, Kihara T, Hongo H, Wu X, Kem WR, Shimohama S, Akaike A, Niidome T, Sugimoto H. Neuroprotection by donepezil against glutamate excitotoxicity involves stimulation of alpha7 nicotinic receptors and internalization of NMDA receptors. British Journal of Pharmacology. 161: 127-39. PMID 20718745 DOI: 10.1111/J.1476-5381.2010.00894.X |
0.318 |
|
| 2010 |
Nunomura A, Tamaoki T, Tanaka K, Motohashi N, Nakamura M, Hayashi T, Yamaguchi H, Shimohama S, Lee HG, Zhu X, Smith MA, Perry G. Intraneuronal amyloid beta accumulation and oxidative damage to nucleic acids in Alzheimer disease. Neurobiology of Disease. 37: 731-7. PMID 20034567 DOI: 10.1016/J.Nbd.2009.12.012 |
0.564 |
|
| 2010 |
Aoyagi N, Uemura K, Kuzuya A, Kihara T, Kawamata J, Shimohama S, Kinoshita A, Takahashi R. PI3K inhibition causes the accumulation of ubiquitinated presenilin 1 without affecting the proteasome activity. Biochemical and Biophysical Research Communications. 391: 1240-5. PMID 20006583 DOI: 10.1016/J.Bbrc.2009.12.051 |
0.34 |
|
| 2010 |
Takata K, Kitamura Y, Shimohama S, Taniguchi T. Amyloid-β-dependent tangle maturation in Alzheimer's disease Neuroscience Research. 68: e303. DOI: 10.1016/J.Neures.2010.07.1346 |
0.326 |
|
| 2010 |
Takata K, Kitamura Y, Matsuoka Y, Shimohama S, Taniguchi T. O4-06-03: Aβ/APP-dependent tangle modification via WAVE accumulation in Alzheimer's disease Alzheimer's & Dementia. 6: S160-S160. DOI: 10.1016/J.Jalz.2010.05.498 |
0.318 |
|
| 2009 |
Takata K, Kitamura Y, Nakata Y, Matsuoka Y, Tomimoto H, Taniguchi T, Shimohama S. Involvement of WAVE accumulation in Abeta/APP pathology-dependent tangle modification in Alzheimer's disease. The American Journal of Pathology. 175: 17-24. PMID 19497998 DOI: 10.2353/Ajpath.2009.080908 |
0.353 |
|
| 2009 |
Shimohama S. Nicotinic receptor-mediated neuroprotection in neurodegenerative disease models. Biological & Pharmaceutical Bulletin. 32: 332-6. PMID 19252273 DOI: 10.1248/Bpb.32.332 |
0.372 |
|
| 2009 |
Takeuchi H, Yanagida T, Inden M, Takata K, Kitamura Y, Yamakawa K, Sawada H, Izumi Y, Yamamoto N, Kihara T, Uemura K, Inoue H, Taniguchi T, Akaike A, Takahashi R, ... Shimohama S, et al. Nicotinic receptor stimulation protects nigral dopaminergic neurons in rotenone-induced Parkinson's disease models. Journal of Neuroscience Research. 87: 576-85. PMID 18803299 DOI: 10.1002/Jnr.21869 |
0.331 |
|
| 2008 |
Yanagida T, Takeuchi H, Kitamura Y, Takata K, Minamino H, Shibaike T, Tsushima J, Kishimoto K, Yasui H, Taniguchi T, Shimohama S. Synergistic effect of galantamine on nicotine-induced neuroprotection in hemiparkinsonian rat model. Neuroscience Research. 62: 254-61. PMID 18845194 DOI: 10.1016/J.Neures.2008.09.003 |
0.309 |
|
| 2008 |
Hisahara S, Chiba S, Matsumoto H, Tanno M, Yagi H, Shimohama S, Sato M, Horio Y. Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation. Proceedings of the National Academy of Sciences of the United States of America. 105: 15599-604. PMID 18829436 DOI: 10.1073/Pnas.0800612105 |
0.307 |
|
| 2008 |
Shimohama S. [Treatment of Alzheimer's disease: status quo and future considerations]. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica. 131: 351-6. PMID 18480565 DOI: 10.1254/Fpj.131.351 |
0.309 |
|
| 2008 |
Zhu X, Wang Y, Ogawa O, Lee HG, Raina AK, Fujioka H, Shimohama S, Atwood CS, Petersen RB, Perry G, Smith MA. Oral Presentations OP01: Neurodegenerative Diseases Journal of Neurochemistry. 81: 76-76. DOI: 10.1046/J.1471-4159.81.S1.44_1.X |
0.582 |
|
| 2008 |
Konishi Y, Kato T, Shimohama S, Tsuji T, Akatsu H, Tooyama I. P1-481: Alpha 1-chimaerin protein can interact with beta-amyloid peptides and is expressed at reduced levels in Alzheimer's brain Alzheimer's & Dementia. 4: T360-T360. DOI: 10.1016/J.Jalz.2008.05.1064 |
0.336 |
|
| 2007 |
Inden M, Kitamura Y, Takeuchi H, Yanagida T, Takata K, Kobayashi Y, Taniguchi T, Yoshimoto K, Kaneko M, Okuma Y, Taira T, Ariga H, Shimohama S. Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone. Journal of Neurochemistry. 101: 1491-1504. PMID 17459145 DOI: 10.1111/J.1471-4159.2006.04440.X |
0.321 |
|
| 2007 |
Uemura K, Kuzuya A, Shimozono Y, Aoyagi N, Ando K, Shimohama S, Kinoshita A. GSK3beta activity modifies the localization and function of presenilin 1. The Journal of Biological Chemistry. 282: 15823-32. PMID 17389597 DOI: 10.1074/Jbc.M610708200 |
0.319 |
|
| 2007 |
Uemura K, Kuzuya A, Aoyagi N, Ando K, Shimozono Y, Ninomiya H, Shimohama S, Kinoshita A. Amyloid beta inhibits ectodomain shedding of N-cadherin via down-regulation of cell-surface NMDA receptor. Neuroscience. 145: 5-10. PMID 17257767 DOI: 10.1016/J.Neuroscience.2006.12.022 |
0.321 |
|
| 2007 |
Takata K, Kitamura Y, Yanagisawa D, Morikawa S, Morita M, Inubushi T, Tsuchiya D, Chishiro S, Saeki M, Taniguchi T, Shimohama S, Tooyama I. Microglial transplantation increases amyloid-beta clearance in Alzheimer model rats. Febs Letters. 581: 475-8. PMID 17240371 DOI: 10.1016/J.Febslet.2007.01.009 |
0.335 |
|
| 2007 |
Yamamoto N, Sawada H, Izumi Y, Kume T, Katsuki H, Shimohama S, Akaike A. Proteasome inhibition induces glutathione synthesis and protects cells from oxidative stress: relevance to Parkinson disease. The Journal of Biological Chemistry. 282: 4364-72. PMID 17158454 DOI: 10.1074/Jbc.M603712200 |
0.33 |
|
| 2007 |
Kuzuya A, Uemura K, Kitagawa N, Aoyagi N, Kihara T, Ninomiya H, Ishiura S, Takahashi R, Shimohama S. Presenilin 1 is involved in the maturation of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1). Journal of Neuroscience Research. 85: 153-65. PMID 17075903 DOI: 10.1002/Jnr.21104 |
0.339 |
|
| 2006 |
Tsuchiya D, Kitamura Y, Takata K, Taniguchi T, Uemura K, Miki H, Takenawa T, Shimohama S. Morphological change by overexpression of D385A dominant negative presenilin 1 in human neuroblastoma SH-SY5Y cells. Journal of Pharmacological Sciences. 102: 354-8. PMID 17099291 DOI: 10.1254/Jphs.Sc0060118 |
0.343 |
|
| 2006 |
Akatsu H, Yamagata HD, Kawamata J, Kamino K, Takeda M, Yamamoto T, Miki T, Tooyama I, Shimohama S, Kosaka K. Variations in the BDNF gene in autopsy-confirmed Alzheimer's disease and dementia with Lewy bodies in Japan. Dementia and Geriatric Cognitive Disorders. 22: 216-22. PMID 16899999 DOI: 10.1159/000094933 |
0.318 |
|
| 2006 |
Inden M, Taira T, Kitamura Y, Yanagida T, Tsuchiya D, Takata K, Yanagisawa D, Nishimura K, Taniguchi T, Kiso Y, Yoshimoto K, Agatsuma T, Koide-Yoshida S, Iguchi-Ariga SM, Shimohama S, et al. PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson's disease rat model. Neurobiology of Disease. 24: 144-58. PMID 16860563 DOI: 10.1016/J.Nbd.2006.06.004 |
0.307 |
|
| 2006 |
Uemura K, Kihara T, Kuzuya A, Okawa K, Nishimoto T, Bito H, Ninomiya H, Sugimoto H, Kinoshita A, Shimohama S. Activity-dependent regulation of beta-catenin via epsilon-cleavage of N-cadherin. Biochemical and Biophysical Research Communications. 345: 951-8. PMID 16707106 DOI: 10.1016/J.Bbrc.2006.04.157 |
0.306 |
|
| 2006 |
Kihara T, Sugimoto H, Shimohama S. P4-266: Protective effects of nicotinic receptor stimulation with nicotine or acetylcholinesterase inhibitors against beta amyloid- or glutamate-induced neuronal death Alzheimer's & Dementia. 2: S594-S595. DOI: 10.1016/J.Jalz.2006.05.2005 |
0.327 |
|
| 2006 |
Tsuji T, Kawamata J, Uemura K, Okawa K, Hirayoshi I, Shimohama S. P3-091: Neuroproteomics in Alzheimer's disease: Expression profiling of the brain proteomes and their relation to proteomes of body fluids Alzheimer's & Dementia. 2: S400-S400. DOI: 10.1016/J.Jalz.2006.05.1358 |
0.315 |
|
| 2005 |
Nakamizo T, Kawamata J, Yamashita H, Kanki R, Kihara T, Sawada H, Akaike A, Shimohama S. Stimulation of nicotinic acetylcholine receptors protects motor neurons. Biochemical and Biophysical Research Communications. 330: 1285-9. PMID 15823582 DOI: 10.1016/J.Bbrc.2005.03.115 |
0.305 |
|
| 2005 |
Honda K, Smith MA, Zhu X, Baus D, Merrick WC, Tartakoff AM, Hattier T, Harris PL, Siedlak SL, Fujioka H, Liu Q, Moreira PI, Miller FP, Nunomura A, Shimohama S, et al. Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron. The Journal of Biological Chemistry. 280: 20978-86. PMID 15767256 DOI: 10.1074/Jbc.M500526200 |
0.506 |
|
| 2005 |
Liu Q, Smith MA, Avilá J, DeBernardis J, Kansal M, Takeda A, Zhu X, Nunomura A, Honda K, Moreira PI, Oliveira CR, Santos MS, Shimohama S, Aliev G, de la Torre J, et al. Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations. Free Radical Biology & Medicine. 38: 746-54. PMID 15721985 DOI: 10.1016/J.Freeradbiomed.2004.11.005 |
0.538 |
|
| 2005 |
Izumi Y, Sawada H, Sakka N, Yamamoto N, Kume T, Katsuki H, Shimohama S, Akaike A. p-Quinone mediates 6-hydroxydopamine-induced dopaminergic neuronal death and ferrous iron accelerates the conversion of p-quinone into melanin extracellularly. Journal of Neuroscience Research. 79: 849-60. PMID 15712215 DOI: 10.1002/Jnr.20382 |
0.317 |
|
| 2005 |
Inden M, Kondo J, Kitamura Y, Takata K, Nishimura K, Taniguchi T, Sawada H, Shimohama S. Proteasome inhibitors protect against degeneration of nigral dopaminergic neurons in hemiparkinsonian rats. Journal of Pharmacological Sciences. 97: 203-11. PMID 15684568 DOI: 10.1254/Jphs.Fp0040525 |
0.334 |
|
| 2005 |
Kitamura Y, Yanagisawa D, Inden M, Takata K, Tsuchiya D, Kawasaki T, Taniguchi T, Shimohama S. Recovery of focal brain ischemia-induced behavioral dysfunction by intracerebroventricular injection of microglia. Journal of Pharmacological Sciences. 97: 289-93. PMID 15684564 DOI: 10.1254/Jphs.Sc0040129 |
0.308 |
|
| 2004 |
Uemura K, Kuzuya A, Shimohama S. Protein trafficking and Alzheimer's disease. Current Alzheimer Research. 1: 1-10. PMID 15975080 DOI: 10.2174/1567205043480528 |
0.373 |
|
| 2004 |
Kihara T, Sawada H, Nakamizo T, Kanki R, Yamashita H, Maelicke A, Shimohama S. Galantamine modulates nicotinic receptor and blocks Abeta-enhanced glutamate toxicity. Biochemical and Biophysical Research Communications. 325: 976-82. PMID 15541385 DOI: 10.1016/J.Bbrc.2004.10.132 |
0.336 |
|
| 2004 |
Takata K, Kitamura Y, Tsuchiya D, Kawasaki T, Taniguchi T, Shimohama S. High mobility group box protein-1 inhibits microglial Abeta clearance and enhances Abeta neurotoxicity. Journal of Neuroscience Research. 78: 880-91. PMID 15499593 DOI: 10.1002/Jnr.20340 |
0.37 |
|
| 2004 |
Nagasawa K, Nishida K, Nagai K, Shimohama S, Fujimoto S. Differential expression profiles of PLC-beta1 and -delta1 in primary cultured rat cortical neurons treated with N-methyl-D-aspartate and peroxynitrite. Neuroscience Letters. 367: 246-9. PMID 15331163 DOI: 10.1016/J.Neulet.2004.06.015 |
0.355 |
|
| 2004 |
Nagasawa K, Aoki H, Yasuda E, Nagai K, Shimohama S, Fujimoto S. Possible involvement of group I mGluRs in neuroprotective effect of theanine. Biochemical and Biophysical Research Communications. 320: 116-22. PMID 15207710 DOI: 10.1016/J.Bbrc.2004.05.143 |
0.317 |
|
| 2004 |
Shiozaki A, Tsuji T, Kohno R, Kawamata J, Uemura K, Teraoka H, Shimohama S. Proteome analysis of brain proteins in Alzheimer's disease: subproteomics following sequentially extracted protein preparation. Journal of Alzheimer's Disease : Jad. 6: 257-68. PMID 15201480 DOI: 10.3233/Jad-2004-6306 |
0.335 |
|
| 2004 |
Zhu X, Wang Y, Ogawa O, Lee HG, Raina AK, Siedlak SL, Harris PL, Fujioka H, Shimohama S, Tabaton M, Atwood CS, Petersen RB, Perry G, Smith MA. Neuroprotective properties of Bcl-w in Alzheimer disease. Journal of Neurochemistry. 89: 1233-40. PMID 15147516 DOI: 10.1111/J.1471-4159.2004.02416.X |
0.586 |
|
| 2004 |
Sawada H, Kohno R, Kihara T, Izumi Y, Sakka N, Ibi M, Nakanishi M, Nakamizo T, Yamakawa K, Shibasaki H, Yamamoto N, Akaike A, Inden M, Kitamura Y, Taniguchi T, ... Shimohama S, et al. Proteasome mediates dopaminergic neuronal degeneration, and its inhibition causes alpha-synuclein inclusions. The Journal of Biological Chemistry. 279: 10710-9. PMID 14672949 DOI: 10.1074/Jbc.M308434200 |
0.343 |
|
| 2003 |
Raina AK, Zhu X, Shimohama S, Perry G, Smith MA. Tipping the apoptotic balance in Alzheimer's disease: the abortosis concept. Cell Biochemistry and Biophysics. 39: 249-55. PMID 14716079 DOI: 10.1385/Cbb:39:3:249 |
0.549 |
|
| 2003 |
Sakka N, Sawada H, Izumi Y, Kume T, Katsuki H, Kaneko S, Shimohama S, Akaike A. Dopamine is involved in selectivity of dopaminergic neuronal death by rotenone. Neuroreport. 14: 2425-8. PMID 14663204 DOI: 10.1097/00001756-200312190-00027 |
0.321 |
|
| 2003 |
Kitamura Y, Tsuchiya D, Takata K, Shibagaki K, Taniguchi T, Smith MA, Perry G, Miki H, Takenawa T, Shimohama S. Possible involvement of Wiskott-Aldrich syndrome protein family in aberrant neuronal sprouting in Alzheimer's disease. Neuroscience Letters. 346: 149-52. PMID 12853106 DOI: 10.1016/S0304-3940(03)00506-8 |
0.572 |
|
| 2003 |
Uemura K, Kitagawa N, Kohno R, Kuzuya A, Kageyama T, Shibasaki H, Shimohama S. Presenilin 1 mediates retinoic acid-induced differentiation of SH-SY5Y cells through facilitation of Wnt signaling. Journal of Neuroscience Research. 73: 166-75. PMID 12836159 DOI: 10.1002/Jnr.10641 |
0.314 |
|
| 2003 |
Kitamura Y, Shibagaki K, Takata K, Tsuchiya D, Taniguchi T, Gebicke-Haerter PJ, Miki H, Takenawa T, Shimohama S. Involvement of Wiskott-Aldrich syndrome protein family verprolin-homologous protein (WAVE) and Rac1 in the phagocytosis of amyloid-beta(1-42) in rat microglia. Journal of Pharmacological Sciences. 92: 115-23. PMID 12832839 DOI: 10.1254/Jphs.92.115 |
0.309 |
|
| 2003 |
Takata K, Kitamura Y, Umeki M, Tsuchiya D, Kakimura J, Taniguchi T, Gebicke-Haerter PJ, Shimohama S. Possible involvement of small oligomers of amyloid-beta peptides in 15-deoxy-delta 12,14 prostaglandin J2-sensitive microglial activation. Journal of Pharmacological Sciences. 91: 330-3. PMID 12719662 DOI: 10.1254/Jphs.91.330 |
0.302 |
|
| 2003 |
Raina AK, Hochman A, Ickes H, Zhu X, Ogawa O, Cash AD, Shimohama S, Perry G, Smith MA. Apoptotic promoters and inhibitors in Alzheimer's disease: Who wins out? Progress in Neuro-Psychopharmacology & Biological Psychiatry. 27: 251-4. PMID 12657364 DOI: 10.1016/S0278-5846(03)00020-4 |
0.578 |
|
| 2003 |
Takata K, Kitamura Y, Kakimura J, Shibagaki K, Tsuchiya D, Taniguchi T, Smith MA, Perry G, Shimohama S. Role of high mobility group protein-1 (HMG1) in amyloid-beta homeostasis. Biochemical and Biophysical Research Communications. 301: 699-703. PMID 12565837 DOI: 10.1016/S0006-291X(03)00024-X |
0.544 |
|
| 2003 |
Kitagawa N, Shimohama S, Oeda T, Uemura K, Kohno R, Kuzuya A, Shibasaki H, Ishii N. The role of the presenilin-1 homologue gene sel-12 of Caenorhabditis elegans in apoptotic activities. The Journal of Biological Chemistry. 278: 12130-4. PMID 12556527 DOI: 10.1074/Jbc.M212058200 |
0.323 |
|
| 2003 |
Kitamura Y, Ishida Y, Takata K, Mizutani H, Kakimura J, Inden M, Nakata J, Taniguchi T, Tsukahara T, Akaike A, Shimohama S. Hyperbilirubinemia protects against focal ischemia in rats. Journal of Neuroscience Research. 71: 544-50. PMID 12548710 DOI: 10.1002/Jnr.10514 |
0.303 |
|
| 2003 |
Nakamizo T, Kawamata J, Yoshida K, Kawai Y, Kanki R, Sawada H, Kihara T, Yamashita H, Shibasaki H, Akaike A, Shimohama S. Phosphodiesterase inhibitors are neuroprotective to cultured spinal motor neurons. Journal of Neuroscience Research. 71: 485-95. PMID 12548704 DOI: 10.1002/Jnr.10483 |
0.306 |
|
| 2002 |
Kakimura JI, Kitamura Y, Takata K, Umeki M, Suzuki S, Shibagaki K, Taniguchi T, Nomura Y, Gebicke-Haerter PJ, Smith MA, Perry G, Shimohama S. Microglial activation and amyloid-β clearance induced by exogenous heat-shock proteins. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 16: 601-603. PMID 29470936 DOI: 10.1096/fj.01-0530fje |
0.363 |
|
| 2002 |
Takata K, Kitamura Y, Kakimura J, Shibagaki K, Taniguchi T, Gebicke-Haerter PJ, Smith MA, Perry G, Shimohama S. Possible protective mechanisms of heme oxygenase-1 in the brain. Annals of the New York Academy of Sciences. 977: 501-6. PMID 12480792 DOI: 10.1111/J.1749-6632.2002.Tb04857.X |
0.493 |
|
| 2002 |
Kakimura J, Kitamura Y, Takata K, Tsuchiya D, Taniguchi T, Gebicke-Haerter PJ, Smith MA, Perry G, Shimohama S. Possible involvement of ER chaperone Grp78 on reduced formation of amyloid-beta deposits. Annals of the New York Academy of Sciences. 977: 327-32. PMID 12480769 DOI: 10.1111/J.1749-6632.2002.Tb04834.X |
0.505 |
|
| 2002 |
Tsuji T, Shiozaki A, Kohno R, Yoshizato K, Shimohama S. Proteomic profiling and neurodegeneration in Alzheimer's disease. Neurochemical Research. 27: 1245-53. PMID 12462422 DOI: 10.1023/A:1020941929414 |
0.306 |
|
| 2002 |
Perry G, Taddeo MA, Nunomura A, Zhu X, Zenteno-Savin T, Drew KL, Shimohama S, Avila J, Castellani RJ, Smith MA. Comparative biology and pathology of oxidative stress in Alzheimer and other neurodegenerative diseases: beyond damage and response. Comparative Biochemistry and Physiology. Toxicology & Pharmacology : Cbp. 133: 507-13. PMID 12458179 DOI: 10.1016/S1532-0456(02)00119-9 |
0.53 |
|
| 2002 |
Perry G, Nunomura A, Cash AD, Taddeo MA, Hirai K, Aliev G, Avila J, Wataya T, Shimohama S, Atwood CS, Smith MA. Reactive oxygen: its sources and significance in Alzheimer disease. Journal of Neural Transmission. Supplementum. 69-75. PMID 12456052 DOI: 10.1007/978-3-7091-6139-5_7 |
0.523 |
|
| 2002 |
Kitamura Y, Inden M, Miyamura A, Kakimura J, Taniguchi T, Shimohama S. Possible involvement of both mitochondria- and endoplasmic reticulum-dependent caspase pathways in rotenone-induced apoptosis in human neuroblastoma SH-SY5Y cells. Neuroscience Letters. 333: 25-8. PMID 12401552 DOI: 10.1016/S0304-3940(02)00964-3 |
0.31 |
|
| 2002 |
Kihara T, Shimohama S, Sawada H, Honda K, Nakamizo T, Kanki R, Yamashita H, Akaike A. Protective effect of dopamine D2 agonists in cortical neurons via the phosphatidylinositol 3 kinase cascade. Journal of Neuroscience Research. 70: 274-82. PMID 12391586 DOI: 10.1002/Jnr.10426 |
0.363 |
|
| 2002 |
Kawamata J, Shimohama S. Association of novel and established polymorphisms in neuronal nicotinic acetylcholine receptors with sporadic Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 4: 71-6. PMID 12214130 DOI: 10.3233/Jad-2002-4201 |
0.361 |
|
| 2002 |
Sawada H, Ibi M, Kihara T, Honda K, Nakamizo T, Kanki R, Nakanishi M, Sakka N, Akaike A, Shimohama S. Estradiol protects dopaminergic neurons in a MPP+Parkinson's disease model. Neuropharmacology. 42: 1056-64. PMID 12128007 DOI: 10.1016/S0028-3908(02)00049-7 |
0.358 |
|
| 2002 |
Kakimura J, Kitamura Y, Takata K, Umeki M, Suzuki S, Shibagaki K, Taniguchi T, Nomura Y, Gebicke-Haerter PJ, Smith MA, Perry G, Shimohama S. Microglial activation and amyloid-beta clearance induced by exogenous heat-shock proteins. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 16: 601-3. PMID 11919167 DOI: 10.1096/Fj.01-0530Fje |
0.547 |
|
| 2002 |
Kume T, Asai N, Nishikawa H, Mano N, Terauchi T, Taguchi R, Shirakawa H, Osakada F, Mori H, Asakawa N, Yonaga M, Nishizawa Y, Sugimoto H, Shimohama S, Katsuki H, et al. Isolation of a diterpenoid substance with potent neuroprotective activity from fetal calf serum. Proceedings of the National Academy of Sciences of the United States of America. 99: 3288-93. PMID 11867740 DOI: 10.1073/Pnas.052693999 |
0.311 |
|
| 2002 |
Castellani RJ, Perry G, Siedlak SL, Nunomura A, Shimohama S, Zhang J, Montine T, Sayre LM, Smith MA. Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans. Neuroscience Letters. 319: 25-8. PMID 11814645 DOI: 10.1016/S0304-3940(01)02514-9 |
0.498 |
|
| 2002 |
Wataya T, Nunomura A, Smith MA, Siedlak SL, Harris PL, Shimohama S, Szweda LI, Kaminski MA, Avila J, Price DL, Cleveland DW, Sayre LM, Perry G. High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal. The Journal of Biological Chemistry. 277: 4644-8. PMID 11733539 DOI: 10.1074/Jbc.M110913200 |
0.511 |
|
| 2001 |
Tanino H, Kusuda T, Nagasawa K, Shimohama S, Fujimoto S. Alterations of phospholipase C isozymes in rat cerebral cortex through hyperoxia. Biological & Pharmaceutical Bulletin. 24: 1241-5. PMID 11725956 DOI: 10.1248/Bpb.24.1241 |
0.302 |
|
| 2001 |
Shimohama S, Tanino H, Fujimoto S. Differential subcellular localization of caspase family proteins in the adult rat brain. Neuroscience Letters. 315: 125-8. PMID 11716979 DOI: 10.1016/S0304-3940(01)02336-9 |
0.304 |
|
| 2001 |
Zhu X, Rottkamp CA, Hartzler A, Sun Z, Takeda A, Boux H, Shimohama S, Perry G, Smith MA. Activation of MKK6, an upstream activator of p38, in Alzheimer's disease. Journal of Neurochemistry. 79: 311-8. PMID 11677259 DOI: 10.1046/J.1471-4159.2001.00597.X |
0.488 |
|
| 2001 |
Urushitani M, Shimohama S. The role of nitric oxide in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group On Motor Neuron Diseases. 2: 71-81. PMID 11675875 DOI: 10.1080/146608201316949415 |
0.328 |
|
| 2001 |
Nunomura A, Perry G, Aliev G, Hirai K, Takeda A, Balraj EK, Jones PK, Ghanbari H, Wataya T, Shimohama S, Chiba S, Atwood CS, Petersen RB, Smith MA. Oxidative damage is the earliest event in Alzheimer disease. Journal of Neuropathology and Experimental Neurology. 60: 759-67. PMID 11487050 DOI: 10.1093/Jnen/60.8.759 |
0.572 |
|
| 2001 |
Honda K, Shimohama S, Sawada H, Kihara T, Nakamizo T, Shibasaki H, Akaike A. Nongenomic antiapoptotic signal transduction by estrogen in cultured cortical neurons. Journal of Neuroscience Research. 64: 466-75. PMID 11391701 DOI: 10.1002/Jnr.1098 |
0.333 |
|
| 2001 |
Hirai K, Aliev G, Nunomura A, Fujioka H, Russell RL, Atwood CS, Johnson AB, Kress Y, Vinters HV, Tabaton M, Shimohama S, Cash AD, Siedlak SL, Harris PL, Jones PK, et al. Mitochondrial abnormalities in Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 3017-23. PMID 11312286 |
0.383 |
|
| 2001 |
Kitamura Y, Ishida Y, Takata K, Kakimura J, Mizutani H, Shimohama S, Akaike A, Taniguchi T. Alpha-synuclein protein is not scavenged in neuronal loss induced by kainic acid or focal ischemia. Brain Research. 898: 181-5. PMID 11292464 DOI: 10.1016/S0006-8993(01)02159-X |
0.325 |
|
| 2001 |
Kihara T, Shimohama S, Sawada H, Honda K, Nakamizo T, Shibasaki H, Kume T, Akaike A. alpha 7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A beta-amyloid-induced neurotoxicity. The Journal of Biological Chemistry. 276: 13541-6. PMID 11278378 DOI: 10.1074/Jbc.M008035200 |
0.311 |
|
| 2001 |
Shimohama S, Kihara T. Nicotinic receptor-mediated protection against beta-amyloid neurotoxicity. Biological Psychiatry. 49: 233-9. PMID 11230874 DOI: 10.1016/S0006-3223(00)01100-8 |
0.352 |
|
| 2001 |
Kakimura J, Kitamura Y, Taniguchi T, Shimohama S, Gebicke-Haerter PJ. Bip/GRP78-induced production of cytokines and uptake of amyloid-beta(1-42) peptide in microglia. Biochemical and Biophysical Research Communications. 281: 6-10. PMID 11178952 DOI: 10.1006/Bbrc.2001.4299 |
0.351 |
|
| 2001 |
Hirai K, Aliev G, Nunomura A, Fujioka H, Russell RL, Atwood CS, Johnson AB, Kress Y, Vinters HV, Tabaton M, Shimohama S, Cash AD, Siedlak SL, Harris PLR, Jones PK, et al. Mitochondrial Abnormalities in Alzheimer's Disease The Journal of Neuroscience. 21: 3017-3023. DOI: 10.1523/Jneurosci.21-09-03017.2001 |
0.465 |
|
| 2000 |
Kim HT, Russell RL, Raina AK, Harris PL, Siedlak SL, Zhu X, Petersen RB, Shimohama S, Smith MA, Perry G. Protein disulfide isomerase in Alzheimer disease. Antioxidants & Redox Signaling. 2: 485-9. PMID 11229362 DOI: 10.1089/15230860050192260 |
0.578 |
|
| 2000 |
Shimohama S. Apoptosis in Alzheimer's disease--an update. Apoptosis : An International Journal On Programmed Cell Death. 5: 9-16. PMID 11227497 DOI: 10.1023/A:1009625323388 |
0.402 |
|
| 2000 |
Kitamura Y, Shimohama S, Akaike A, Taniguchi T. The parkinsonian models: invertebrates to mammals. Japanese Journal of Pharmacology. 84: 237-43. PMID 11138723 DOI: 10.1254/Jjp.84.237 |
0.308 |
|
| 2000 |
Nakamizo T, Urushitani M, Inoue R, Shinohara A, Sawada H, Honda K, Kihara T, Akaike A, Shimohama S. Protection of cultured spinal motor neurons by estradiol. Neuroreport. 11: 3493-7. PMID 11095506 DOI: 10.1097/00001756-200011090-00019 |
0.301 |
|
| 2000 |
Imura T, Shimohama S. Opposing effects of adenosine on the survival of glial cells exposed to chemical ischemia. Journal of Neuroscience Research. 62: 539-46. PMID 11070497 DOI: 10.1002/1097-4547(20001115)62:4<539::Aid-Jnr8>3.0.Co;2-E |
0.307 |
|
| 2000 |
Urushitani M, Inoue R, Nakamizo T, Sawada H, Shibasaki H, Shimohama S. Neuroprotective effect of cyclic GMP against radical-induced toxicity in cultured spinal motor neurons. Journal of Neuroscience Research. 61: 443-8. PMID 10931531 DOI: 10.1002/1097-4547(20000815)61:4<443::Aid-Jnr11>3.0.Co;2-W |
0.31 |
|
| 2000 |
Shimohama S, Tanino H, Kawakami N, Okamura N, Kodama H, Yamaguchi T, Hayakawa T, Nunomura A, Chiba S, Perry G, Smith MA, Fujimoto S. Activation of NADPH oxidase in Alzheimer's disease brains. Biochemical and Biophysical Research Communications. 273: 5-9. PMID 10873554 DOI: 10.1006/Bbrc.2000.2897 |
0.579 |
|
| 2000 |
Sawada H, Ibi M, Kihara T, Urushitani M, Honda K, Nakanishi M, Akaike A, Shimohama S. Mechanisms of antiapoptotic effects of estrogens in nigral dopaminergic neurons. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 14: 1202-14. PMID 10834942 DOI: 10.1096/Fasebj.14.9.1202 |
0.316 |
|
| 2000 |
Tanino H, Shimohama S, Sasaki Y, Sumida Y, Fujimoto S. Increase in phospholipase C-delta1 protein levels in aluminum-treated rat brains. Biochemical and Biophysical Research Communications. 271: 620-5. PMID 10814511 DOI: 10.1006/Bbrc.2000.2679 |
0.339 |
|
| 2000 |
Honda K, Sawada H, Kihara T, Urushitani M, Nakamizo T, Akaike A, Shimohama S. Phosphatidylinositol 3-kinase mediates neuroprotection by estrogen in cultured cortical neurons. Journal of Neuroscience Research. 60: 321-7. PMID 10797534 DOI: 10.1002/(Sici)1097-4547(20000501)60:3<321::Aid-Jnr6>3.0.Co;2-T |
0.334 |
|
| 2000 |
Sawada H, Ibi M, Kihara T, Urushitani M, Nakanishi M, Akaike A, Shimohama S. Neuroprotective mechanism of glial cell line-derived neurotrophic factor in mesencephalic neurons. Journal of Neurochemistry. 74: 1175-84. PMID 10693950 DOI: 10.1046/J.1471-4159.2000.741175.X |
0.33 |
|
| 2000 |
Kume T, Nishikawa H, Tomioka H, Katsuki H, Akaike A, Kaneko S, Maeda T, Kihara T, Shimohama S. p75-mediated neuroprotection by NGF against glutamate cytotoxicity in cortical cultures. Brain Research. 852: 279-89. PMID 10678754 DOI: 10.1016/S0006-8993(99)02226-X |
0.315 |
|
| 1999 |
Sawada H, Shimohama S. MPP(+) and glutamate in the degeneration of nigral dopaminergic neurons. Parkinsonism & Related Disorders. 5: 209-15. PMID 18591142 DOI: 10.1016/S1353-8020(99)00039-5 |
0.321 |
|
| 1999 |
Ibi M, Sawada H, Kume T, Katsuki H, Kaneko S, Shimohama S, Akaike A. Depletion of intracellular glutathione increases susceptibility to nitric oxide in mesencephalic dopaminergic neurons. Journal of Neurochemistry. 73: 1696-703. PMID 10501217 DOI: 10.1046/J.1471-4159.1999.731696.X |
0.317 |
|
| 1999 |
Tsuji T, Shimohama S, Kamiya S, Sazuka T, Ohara O. Analysis of brain proteins in Alzheimer's disease using high-resolution two-dimensional gel electrophoresis. Journal of the Neurological Sciences. 166: 100-6. PMID 10475102 DOI: 10.1016/S0022-510X(99)00120-3 |
0.359 |
|
| 1999 |
Shimohama S, Kamiya S, Taniguchi T, Sumida Y, Fujimoto S. Differential involvement of small G proteins in Alzheimer's disease. International Journal of Molecular Medicine. 3: 597-600. PMID 10341289 DOI: 10.3892/Ijmm.3.6.597 |
0.361 |
|
| 1999 |
Kihara T, Shimohama S, Akaike A. Effects of nicotinic receptor agonists on beta-amyloid beta-sheet formation. Japanese Journal of Pharmacology. 79: 393-6. PMID 10230869 DOI: 10.1254/Jjp.79.393 |
0.302 |
|
| 1999 |
Kawasaki H, Fujii H, Gotoh Y, Morooka T, Shimohama S, Nishida E, Hirano T. Requirement for mitogen-activated protein kinase in cerebellar long term depression. The Journal of Biological Chemistry. 274: 13498-502. PMID 10224117 DOI: 10.1074/Jbc.274.19.13498 |
0.305 |
|
| 1999 |
Kitamura Y, Taniguchi T, Shimohama S. Apoptotic cell death in neurons and glial cells: implications for Alzheimer's disease. Japanese Journal of Pharmacology. 79: 1-5. PMID 10082311 DOI: 10.1254/Jjp.79.1 |
0.379 |
|
| 1999 |
Shimohama S, Tanino H, Fujimoto S. Changes in caspase expression in Alzheimer's disease: comparison with development and aging. Biochemical and Biophysical Research Communications. 256: 381-4. PMID 10079193 DOI: 10.1006/Bbrc.1999.0344 |
0.36 |
|
| 1999 |
Kitamura Y, Shimohama S, Koike H, Kakimura Ji, Matsuoka Y, Nomura Y, Gebicke-Haerter PJ, Taniguchi T. Increased expression of cyclooxygenases and peroxisome proliferator-activated receptor-gamma in Alzheimer's disease brains. Biochemical and Biophysical Research Communications. 254: 582-6. PMID 9920782 DOI: 10.1006/Bbrc.1998.9981 |
0.382 |
|
| 1999 |
Kitamura Y, Ota T, Matsuoka Y, Tooyama I, Kimura H, Shimohama S, Nomura Y, Gebicke-Haerter PJ, Taniguchi T. Hydrogen peroxide-induced apoptosis mediated by p53 protein in glial cells. Glia. 25: 154-64. PMID 9890630 DOI: 10.1002/(Sici)1098-1136(19990115)25:2<154::Aid-Glia6>3.0.Co;2-S |
0.318 |
|
| 1999 |
Imura T, Shimohama S, Sato M, Nishikawa H, Madono K, Akaike A, Kimura J. Differential Expression of Small Heat Shock Proteins in Reactive Astrocytes after Focal Ischemia: Possible Role of β-Adrenergic Receptor The Journal of Neuroscience. 19: 9768-9779. DOI: 10.1523/Jneurosci.19-22-09768.1999 |
0.322 |
|
| 1998 |
Hattori N, Kitagawa K, Higashida T, Yagyu K, Shimohama S, Wataya T, Perry G, Smith MA, Inagaki C. CI-ATPase and Na+/K(+)-ATPase activities in Alzheimer's disease brains. Neuroscience Letters. 254: 141-4. PMID 10214977 DOI: 10.1016/S0304-3940(98)00654-5 |
0.529 |
|
| 1998 |
Shimohama S, Kamiya S, Taniguchi T, Kimura J. Intracellular receptors for activated C-kinase in the postmortem human brain: no alteration in Alzheimer disease. Alzheimer Disease and Associated Disorders. 12: 384-6. PMID 9876970 DOI: 10.1097/00002093-199812000-00022 |
0.383 |
|
| 1998 |
Matsushima H, Shimohama S, Kawamata J, Fujimoto S, Takenawa T, Kimura J. Reduction of platelet phospholipase C-delta1 activity in Alzheimer's disease associated with a specific apolipoprotein E genotype (epsilon3/epsilon3). International Journal of Molecular Medicine. 1: 91-3. PMID 9852204 DOI: 10.3892/Ijmm.1.1.91 |
0.321 |
|
| 1998 |
Sawada H, Ibi M, Kihara T, Urushitani M, Akaike A, Shimohama S. Estradiol protects mesencephalic dopaminergic neurons from oxidative stress-induced neuronal death. Journal of Neuroscience Research. 54: 707-19. PMID 9843162 DOI: 10.1002/(Sici)1097-4547(19981201)54:5<707::Aid-Jnr16>3.0.Co;2-T |
0.374 |
|
| 1998 |
Kitamura Y, Ota T, Matsuoka Y, Okazaki M, Kakimura J, Tooyama I, Kimura H, Shimohama S, Gebicke-Haerter PJ, Nomura Y, Taniguchi T. Kainic acid-induced neuronal loss and glial changes in the hippocampal CA3 of p53-deficient mouse. Neuroscience Letters. 255: 57-60. PMID 9839726 DOI: 10.1016/S0304-3940(98)00714-9 |
0.304 |
|
| 1998 |
Urushitani M, Shimohama S, Kihara T, Sawada H, Akaike A, Ibi M, Inoue R, Kitamura Y, Taniguchi T, Kimura J. Mechanism of selective motor neuronal death after exposure of spinal cord to glutamate: involvement of glutamate-induced nitric oxide in motor neuron toxicity and nonmotor neuron protection. Annals of Neurology. 44: 796-807. PMID 9818936 DOI: 10.1002/Ana.410440514 |
0.309 |
|
| 1998 |
Shimohama S, Fujimoto S, Sumida Y, Tanino H. Differential expression of rat brain bcl-2 family proteins in development and aging. Biochemical and Biophysical Research Communications. 252: 92-6. PMID 9813151 DOI: 10.1006/Bbrc.1998.9577 |
0.328 |
|
| 1998 |
Shimohama S, Fujimoto S, Sumida Y, Akagawa K, Shirao T, Matsuoka Y, Taniguchi T. Differential expression of rat brain synaptic proteins in development and aging. Biochemical and Biophysical Research Communications. 251: 394-8. PMID 9790966 DOI: 10.1006/Bbrc.1998.9480 |
0.306 |
|
| 1998 |
Sawada H, Ibi M, Kihara T, Urushitani M, Akaike A, Kimura J, Shimohama S. Dopamine D2-type agonists protect mesencephalic neurons from glutamate neurotoxicity: mechanisms of neuroprotective treatment against oxidative stress. Annals of Neurology. 44: 110-9. PMID 9667598 DOI: 10.1002/Ana.410440117 |
0.316 |
|
| 1998 |
Tsuji T, Shimohama S, Kimura J, Shimizu K. m-Calpain (calcium-activated neutral proteinase) in Alzheimer's disease brains. Neuroscience Letters. 248: 109-12. PMID 9654354 DOI: 10.1016/S0304-3940(98)00348-6 |
0.339 |
|
| 1998 |
Shimohama S, Tanino H, Sumida Y, Tsuda J, Fujimoto S. Alteration of myo-inositol monophosphatase in Alzheimer's disease brains. Neuroscience Letters. 245: 159-62. PMID 9605480 DOI: 10.1016/S0304-3940(98)00209-2 |
0.369 |
|
| 1998 |
Kihara T, Shimohama S, Urushitani M, Sawada H, Kimura J, Kume T, Maeda T, Akaike A. Stimulation of alpha4beta2 nicotinic acetylcholine receptors inhibits beta-amyloid toxicity. Brain Research. 792: 331-4. PMID 9593977 DOI: 10.1016/S0006-8993(98)00138-3 |
0.319 |
|
| 1998 |
Tanaka S, Kawamata J, Shimohama S, Akaki H, Akiguchi I, Kimura J, Ueda K. Inferior temporal lobe atrophy and APOE genotypes in Alzheimer's disease. X-ray computed tomography, magnetic resonance imaging and Xe-133 SPECT studies. Dementia and Geriatric Cognitive Disorders. 9: 90-8. PMID 9524800 DOI: 10.1159/000017029 |
0.301 |
|
| 1998 |
Kitamura Y, Shimohama S, Kamoshima W, Ota T, Matsuoka Y, Nomura Y, Smith MA, Perry G, Whitehouse PJ, Taniguchi T. Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32, in Alzheimer's disease. Brain Research. 780: 260-9. PMID 9507158 DOI: 10.1016/S0006-8993(97)01202-X |
0.558 |
|
| 1998 |
Shimohama S, Sumida Y, Fujimoto S, Matsuoka Y, Taniguchi T, Takenawa T, Kimura J. Differential expression of rat brain phospholipase C isozymes in development and aging. Biochemical and Biophysical Research Communications. 243: 210-6. PMID 9473506 DOI: 10.1006/Bbrc.1998.8090 |
0.306 |
|
| 1998 |
Shimohama S, Sasaki Y, Fujimoto S, Kamiya S, Taniguchi T, Takenawa T, Kimura J. Phospholipase C isozymes in the human brain and their changes in Alzheimer's disease. Neuroscience. 82: 999-1007. PMID 9466424 DOI: 10.1016/S0306-4522(97)00342-4 |
0.321 |
|
| 1997 |
Kitamura Y, Shimohama S, Ota T, Matsuoka Y, Nomura Y, Taniguchi T. Alteration of transcription factors NF-kappaB and STAT1 in Alzheimer's disease brains. Neuroscience Letters. 237: 17-20. PMID 9406869 DOI: 10.1016/S0304-3940(97)00797-0 |
0.33 |
|
| 1997 |
Kaneko S, Maeda T, Kume T, Kochiyama H, Akaike A, Shimohama S, Kimura J. Nicotine protects cultured cortical neurons against glutamate-induced cytotoxicity via alpha7-neuronal receptors and neuronal CNS receptors. Brain Research. 765: 135-40. PMID 9310404 DOI: 10.1016/S0006-8993(97)00556-8 |
0.322 |
|
| 1997 |
Kihara T, Shimohama S, Sawada H, Kimura J, Kume T, Kochiyama H, Maeda T, Akaike A. Nicotinic receptor stimulation protects neurons against beta-amyloid toxicity. Annals of Neurology. 42: 159-63. PMID 9266724 DOI: 10.1002/Ana.410420205 |
0.342 |
|
| 1997 |
Shimohama S, Kamiya S, Taniguchi T, Akagawa K, Kimura J. Differential involvement of synaptic vesicle and presynaptic plasma membrane proteins in Alzheimer's disease. Biochemical and Biophysical Research Communications. 236: 239-42. PMID 9240416 DOI: 10.1006/Bbrc.1997.6940 |
0.32 |
|
| 1997 |
Kume T, Kouchiyama H, Kaneko S, Maeda T, Kaneko S, Akaike A, Shimohama S, Kihara T, Kimura J, Wada K, Koizumi S. BDNF prevents NO mediated glutamate cytotoxicity in cultured cortical neurons. Brain Research. 756: 200-4. PMID 9187333 DOI: 10.1016/S0006-8993(97)00195-9 |
0.315 |
|
| 1997 |
Matsuoka Y, Kitamura Y, Fukunaga R, Shimohama S, Nabeshima T, Tooyama I, Kimura H, Taniguchi T. In vivo hypoxia-induced neuronal damage in dentate gyrus of rat hippocampus: changes in NMDA receptors and the effect of MK-801. Neurochemistry International. 30: 533-42. PMID 9152994 DOI: 10.1016/S0197-0186(96)00125-8 |
0.325 |
|
| 1997 |
Kitamura Y, Shimohama S, Kamoshima W, Matsuoka Y, Nomura Y, Taniguchi T. Changes of p53 in the brains of patients with Alzheimer's disease. Biochemical and Biophysical Research Communications. 232: 418-21. PMID 9125193 DOI: 10.1006/Bbrc.1997.6301 |
0.383 |
|
| 1996 |
Sawada H, Shimohama S, Kawamura T, Akaike A, Kitamura Y, Taniguchi T, Kimura J. Mechanism of resistance to NO-induced neurotoxicity in cultured rat dopaminergic neurons. Journal of Neuroscience Research. 46: 509-18. PMID 8950711 DOI: 10.1002/(Sici)1097-4547(19961115)46:4<509::Aid-Jnr13>3.0.Co;2-T |
0.329 |
|
| 1996 |
Sawada H, Shimohama S, Tamura Y, Kawamura T, Akaike A, Kimura J. Methylphenylpyridium ion (MPP+) enhances glutamate-induced cytotoxicity against dopaminergic neurons in cultured rat mesencephalon. Journal of Neuroscience Research. 43: 55-62. PMID 8838574 DOI: 10.1002/Jnr.490430107 |
0.343 |
|
| 1996 |
Chachin M, Shimohama S, Kunugi YU, Taniguchi T. Assessment of protein kinase C mRNA levels in Alzheimer's disease brains. Japanese Journal of Pharmacology. 71: 175-7. PMID 8835644 DOI: 10.1254/Jjp.71.175 |
0.374 |
|
| 1996 |
Shimohama S, Chachin M, Taniguchi T, Hidaka H, Kimura J. Changes of neurocalcin, a calcium-binding protein, in the brain of patients with Alzheimer's disease. Brain Research. 716: 233-6. PMID 8738246 DOI: 10.1016/0006-8993(96)00070-4 |
0.364 |
|
| 1996 |
Sawada H, Kawamura T, Shimohama S, Akaike A, Kimura J. Different mechanisms of glutamate-induced neuronal death between dopaminergic and non-dopaminergic neurons in rat mesencephalic culture. Journal of Neuroscience Research. 43: 503-10. PMID 8699537 DOI: 10.1002/(Sici)1097-4547(19960215)43:4<503::Aid-Jnr12>3.0.Co;2-2 |
0.331 |
|
| 1996 |
Matsushima H, Shimohama S, Chachin M, Taniguchi T, Kimura J. Ca2+-dependent and Ca2+-independent protein kinase C changes in the brain of patients with Alzheimer's disease. Journal of Neurochemistry. 67: 317-23. PMID 8667008 DOI: 10.1046/J.1471-4159.1996.67010317.X |
0.303 |
|
| 1996 |
Shimohama S, Akaike A, Kimura J. Nicotine-induced protection against glutamate cytotoxicity. Nicotinic cholinergic receptor-mediated inhibition of nitric oxide formation. Annals of the New York Academy of Sciences. 777: 356-61. PMID 8624112 DOI: 10.1111/J.1749-6632.1996.Tb34445.X |
0.311 |
|
| 1995 |
Matsushima H, Shimohama S, Fujimoto S, Takenawa T, Kimura J. Changes in platelet phospholipase C protein level and activity in Alzheimer's disease. Neurobiology of Aging. 16: 895-900. PMID 8622779 DOI: 10.1016/0197-4580(95)02003-9 |
0.359 |
|
| 1995 |
Shimohama S, Fujimoto S, Chachin M, Taniguchi T, Perry G, Whitehouse PJ, Kimura J. Alterations of low molecular weight acid phosphatase protein level in Alzheimer's disease. Brain Research. 699: 125-9. PMID 8616601 DOI: 10.1016/0006-8993(95)00995-3 |
0.468 |
|
| 1995 |
Shimohama S, Matsushima H, Fujimoto S, Takenawa T, Taniguchi T, Kameyama M, Kimura J. Differential involvement of phospholipase C isozymes in Alzheimer's disease. Gerontology. 41: 13-9. PMID 8537014 DOI: 10.1159/000213716 |
0.379 |
|
| 1995 |
Shimohama S, Matsushima H. Signal transduction mechanisms in Alzheimer disease. Alzheimer Disease and Associated Disorders. 9: 15-22. PMID 8534418 DOI: 10.1097/00002093-199501002-00004 |
0.415 |
|
| 1995 |
Shimohama S, Fujimoto S, Matsushima H, Takenawa T, Taniguchi T, Perry G, Whitehouse PJ, Kimura J. Alteration of phospholipase C-delta protein level and specific activity in Alzheimer's disease. Journal of Neurochemistry. 64: 2629-34. PMID 7760043 DOI: 10.1046/J.1471-4159.1995.64062629.X |
0.494 |
|
| 1995 |
Shimohama S, Perry G, Richey P, Praprotnik D, Takenawa T, Fukami K, Whitehouse PJ, Kimura J. Characterization of the association of phospholipase C-delta with Alzheimer neurofibrillary tangles. Brain Research. 669: 217-24. PMID 7712177 DOI: 10.1016/0006-8993(94)01239-E |
0.462 |
|
| 1995 |
Shimohama S, Akaike A, Tamura Y, Matsushima H, Kume T, Fujimoto S, Takenawa T, Kimura J. Glutamate-induced antigenic changes of phospholipase C-delta in cultured cortical neurons. Journal of Neuroscience Research. 41: 418-26. PMID 7563235 DOI: 10.1002/Jnr.490410315 |
0.363 |
|
| 1995 |
Chachin M, Shimohama S, Fujimoto S, Taniguchi T. Changes in low molecular weight acid phosphatase, a phosphotyrosine protein phosphatase, in Alzheimer brains Folia Pharmacologica Japonica. 106: 231-235. DOI: 10.1254/Fpj.106.Supplement_231 |
0.327 |
|
| 1995 |
Matsushima H, Shimohama S, Fujimoto S, Takenawa T, Kimura J. Reduction of platelet phospholipase C activity in patients with Alzheimer disease. Alzheimer Disease & Associated Disorders. 9: 213-217. DOI: 10.1097/00002093-199500940-00007 |
0.371 |
|
| 1994 |
Kawamata J, Tanaka S, Shimohama S, Ueda K, Kimura J. Apolipoprotein E polymorphism in Japanese patients with Alzheimer's disease or vascular dementia. Journal of Neurology, Neurosurgery, and Psychiatry. 57: 1414-6. PMID 7964823 DOI: 10.1136/Jnnp.57.11.1414 |
0.326 |
|
| 1994 |
Matsushima H, Shimohama S, Tanaka S, Taniguchi T, Hagiwara M, Hidaka H, Kimura J. Platelet protein kinase C levels in Alzheimer's disease. Neurobiology of Aging. 15: 671-4. PMID 7891820 DOI: 10.1016/0197-4580(94)90047-7 |
0.353 |
|
| 1993 |
Shimohama S, Fujimoto S, Taniguchi T, Kameyama M, Kimura J. Reduction of low-molecular-weight acid phosphatase activity in Alzheimer brains. Annals of Neurology. 33: 616-21. PMID 8498842 DOI: 10.1002/Ana.410330610 |
0.314 |
|
| 1993 |
Yamaoka Y, Shimohama S, Kimura J, Fukunaga R, Taniguchi T. Changes in protein kinase C isozymes in the rat hippocampus following transient hypoxia. Neuroscience Letters. 154: 20-2. PMID 8361641 DOI: 10.1016/0304-3940(93)90161-D |
0.301 |
|
| 1993 |
Shimohama S, Narita M, Matsushima H, Kimura J, Kameyama M, Hagiwara M, Hidaka H, Taniguchi T. Assessment of protein kinase C isozymes by two-site enzyme immunoassay in human brains and changes in Alzheimer's disease. Neurology. 43: 1407-13. PMID 8327146 DOI: 10.1212/Wnl.43.7.1407 |
0.357 |
|
| 1993 |
Shimohama S, Fujimoto S, Tresser N, Richey P, Perry G, Whitehouse PJ, Homma Y, Takenawa T, Taniguchi T, Suenaga T. Aberrant phosphoinositide metabolism in Alzheimer's disease. Annals of the New York Academy of Sciences. 695: 46-9. PMID 8239311 DOI: 10.1111/J.1749-6632.1993.Tb23025.X |
0.51 |
|
| 1993 |
Shimohama S, Perry G, Richey P, Takenawa T, Whitehouse PJ, Miyoshi K, Suenaga T, Matsumoto S, Nishimura M, Kimura J. Abnormal accumulation of phospholipase C-delta in filamentous inclusions of human neurodegenerative diseases. Neuroscience Letters. 162: 183-6. PMID 8121625 DOI: 10.1016/0304-3940(93)90591-8 |
0.482 |
|
| 1993 |
Shimohama S, Tamura Y, Akaike A, Tsukahara T, Ohara O, Watanabe S, Kimura J. Brain-derived neurotrophic factor pretreatment exerts a partially protective effect against glutamate-induced neurotoxicity in cultured rat cortical neurons. Neuroscience Letters. 164: 55-8. PMID 7908729 DOI: 10.1016/0304-3940(93)90856-G |
0.318 |
|
| 1993 |
Shimohama S, Ogawa N, Tamura Y, Akaike A, Tsukahara T, Iwata H, Kimura J. Protective effect of nerve growth factor against glutamate-induced neurotoxicity in cultured cortical neurons. Brain Research. 632: 296-302. PMID 7908599 DOI: 10.1016/0006-8993(93)91164-N |
0.31 |
|
| 1992 |
Shimohama S, Fujimoto S, Taniguchi T, Kimura J. Phosphatidylinositol-specific phospholipase C activity in the postmortem human brain: no alteration in Alzheimer's disease. Brain Research. 579: 347-9. PMID 1628221 DOI: 10.1016/0006-8993(92)90073-I |
0.355 |
|
| 1991 |
Araki W, Kitaguchi N, Tokushima Y, Ishii K, Aratake H, Shimohama S, Nakamura S, Kimura J. Trophic effect of beta-amyloid precursor protein on cerebral cortical neurons in culture. Biochemical and Biophysical Research Communications. 181: 265-71. PMID 1958195 DOI: 10.1016/S0006-291X(05)81412-3 |
0.368 |
|
| 1991 |
Shimohama S, Suenaga T, Araki W, Yamaoaka Y, Shimizu K, Kimura J. Presence of calpain II immunoreactivity in senile plaques in Alzheimer's disease. Brain Research. 558: 105-8. PMID 1718565 DOI: 10.1016/0006-8993(91)90722-8 |
0.362 |
|
| 1991 |
Shimohama S, Uehara-Kunugi Y, Terai K, Taniguchi T, Kimura J, Saitoh T. Expression of protein kinase C isozymes in primary neuronal cultures of the rat cerebellum. Journal of Neuroscience Research. 29: 261-70. PMID 1716324 DOI: 10.1002/Jnr.490290217 |
0.332 |
|
| 1990 |
Shimohama S, Ninomiya H, Saitoh T, Terry RD, Fukunaga R, Taniguchi T, Fujiwara M, Kimura J, Kameyama M. Changes in signal transduction in Alzheimer's disease. Journal of Neural Transmission. Supplementum. 30: 69-78. PMID 2391515 DOI: 10.1007/978-3-7091-3345-3_7 |
0.389 |
|
| 1990 |
Masliah E, Cole G, Shimohama S, Hansen L, DeTeresa R, Terry RD, Saitoh T. Differential involvement of protein kinase C isozymes in Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 10: 2113-24. PMID 2376771 DOI: 10.1523/Jneurosci.10-07-02113.1990 |
0.386 |
|
| 1988 |
Shimohama S, Taniguchi T, Fujiwara M, Kameyama M. Changes in benzodiazepine receptors in Alzheimer-type dementia. Annals of Neurology. 23: 404-6. PMID 2837978 DOI: 10.1002/Ana.410230419 |
0.326 |
|
| 1987 |
Shimohama S, Taniguchi T, Fujiwara M, Kameyama M. Changes in beta-adrenergic receptor subtypes in Alzheimer-type dementia. Journal of Neurochemistry. 48: 1215-21. PMID 3029330 DOI: 10.1111/J.1471-4159.1987.Tb05649.X |
0.311 |
|
| 1987 |
Shimohama S, Taniguchi T, Fujiwara M, Kameyama M. Beta adrenergic receptor subtypes in senile dementia of the alzheimer-type Neuroscience Research Supplements. 5: S3. DOI: 10.1016/0921-8696(87)90027-2 |
0.304 |
|
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