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Shun Shimohama, MD, PhD - Related publications

Affiliations: 
Neurology Sapporo Medical University, Sapporo-shi, Hokkaidō, Japan 
Website:
http://www.biomedexperts.com/Profile.bme/1298098/Shun_Shimohama
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50 most relevant papers in past 60 days:
Year Citation  Score
2020 Yang WD, Dong WG. [Mechanisms of electroacupuncture for improving Alzheimer's disease from reducing β amyloid protein level]. Zhen Ci Yan Jiu = Acupuncture Research. 45: 426-31. PMID 32447861 DOI: 10.13702/j.1000-0607.180885   
2020 Deng L, Haynes PA, Wu Y, Amirkhani A, Kamath KS, Wu JX, Pushpitha K, Gupta V, Graham S, Gupta VK, Mirzaei M. Amyloid-beta peptide neurotoxicity in human neuronal cells is associated with modulation of insulin-like growth factor transport, lysosomal machinery and extracellular matrix receptor interactions. Neural Regeneration Research. 15: 2131-2142. PMID 32394972 DOI: 10.4103/1673-5374.282261   
2020 Li X, Li K, Chu F, Huang J, Yang Z. Graphene oxide enhances β-amyloid clearance by inducing autophagy of microglia and neurons. Chemico-Biological Interactions. 325: 109126. PMID 32430275 DOI: 10.1016/j.cbi.2020.109126   
2020 Debasmita T, Alice M, Federica C, Alessandro R, Pamela G, Federica F, Lucia B, Diego A, Juárez-Hernández Leon J, Carlo M, Laura C, Mario S, Wilhelmus Micha MM, Benjamin D, Maria P, et al. Increased transcription of transglutaminase 1 mediates neuronal death in in vitro models of neuronal stress and Aβ1-42-mediated toxicity. Neurobiology of Disease. 104849. PMID 32222473 DOI: 10.1016/j.nbd.2020.104849   
2020 Deng X, Zhao S, Liu X, Han L, Wang R, Hao H, Jiao Y, Han S, Bai C. : a source for anti-Alzheimer's disease drugs. Pharmaceutical Biology. 58: 410-416. PMID 32429787 DOI: 10.1080/13880209.2020.1758732   
2020 Hanafy DM, Prenzler PD, Burrows GE, Gurusinghe S, Thejer BM, Obied HK, Hill RA. Neuroprotective Activity of Species on Hydrogen Peroxide-Induced Apoptosis in SH-SY5Y Cells. Nutrients. 12. PMID 32397683 DOI: 10.3390/nu12051366   
2020 Elsherbini A, Kirov AS, Dinkins MB, Wang G, Qin H, Zhu Z, Tripathi P, Crivelli SM, Bieberich E. Association of Aβ with ceramide-enriched astrosomes mediates Aβ neurotoxicity. Acta Neuropathologica Communications. 8: 60. PMID 32345374 DOI: 10.1186/s40478-020-00931-8   
2020 Lim KH, Joo JY. Predictive Potential of Circulating Ube2h mRNA as an E2 Ubiquitin-Conjugating Enzyme for Diagnosis or Treatment of Alzheimer's Disease. International Journal of Molecular Sciences. 21. PMID 32403399 DOI: 10.3390/ijms21093398   
2020 Kumar D, Ambasta RK, Kumar P. Ubiquitin biology in neurodegenerative disorders: From impairment to therapeutic strategies. Ageing Research Reviews. 101078. PMID 32407951 DOI: 10.1016/j.arr.2020.101078   
2020 Angelopoulou E, Paudel YN, Shaikh MF, Piperi C. Flotillin: A Promising Biomarker for Alzheimer's Disease. Journal of Personalized Medicine. 10. PMID 32225073 DOI: 10.3390/jpm10020020   
2020 Harris LD, Jasem S, Licchesi JDF. The Ubiquitin System in Alzheimer's Disease. Advances in Experimental Medicine and Biology. 1233: 195-221. PMID 32274758 DOI: 10.1007/978-3-030-38266-7_8   
2020 Gee MS, Son SH, Jeon SH, Do J, Kim N, Ju YJ, Lee SJ, Chung EK, Inn KS, Kim NJ, Lee JK. A selective p38α/β MAPK inhibitor alleviates neuropathology and cognitive impairment, and modulates microglia function in 5XFAD mouse. Alzheimer's Research & Therapy. 12: 45. PMID 32317025 DOI: 10.1186/s13195-020-00617-2   
2020 Yang J, Wise L, Fukuchi KI. TLR4 Cross-Talk With NLRP3 Inflammasome and Complement Signaling Pathways in Alzheimer's Disease. Frontiers in Immunology. 11: 724. PMID 32391019 DOI: 10.3389/fimmu.2020.00724   
2020 Cho HJ, Sharma AK, Zhang Y, Gross ML, Mirica LM. A Multifunctional Chemical Agent as an Attenuator of Amyloid Burden and Neuroinflammation in Alzheimer's Disease. Acs Chemical Neuroscience. PMID 32310630 DOI: 10.1021/acschemneuro.0c00114   
2020 Yang Y, Zhou J, Li J. Regulation of exosome for Alzheimer's disease derived from mesenchymal stem cells. Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences. 45: 169-175. PMID 32386043 DOI: 10.11817/j.issn.1672-7347.2020.180779   
2020 Weidling IW, Swerdlow RH. Mitochondria in Alzheimer's disease and their potential role in Alzheimer's proteostasis. Experimental Neurology. 330: 113321. PMID 32339611 DOI: 10.1016/j.expneurol.2020.113321   
2020 Vyas Y, Montgomery JM, Cheyne JE. Hippocampal Deficits in Amyloid-β-Related Rodent Models of Alzheimer's Disease. Frontiers in Neuroscience. 14: 266. PMID 32317913 DOI: 10.3389/fnins.2020.00266   
2020 Uddin MS, Kabir MT, Mamun AA, Barreto GE, Rashid M, Perveen A, Ashraf GM. Pharmacological approaches to mitigate neuroinflammation in Alzheimer's disease. International Immunopharmacology. 84: 106479. PMID 32353686 DOI: 10.1016/j.intimp.2020.106479   
2020 Yuan C, Aierken A, Xie Z, Li N, Zhao J, Qing H. The age-related microglial transformation in Alzheimer's disease pathogenesis. Neurobiology of Aging. 92: 82-91. PMID 32408056 DOI: 10.1016/j.neurobiolaging.2020.03.024   
2020 Song YY, Xu WT, Zhang XC, Ni GX. Mechanisms of Electroacupuncture on Alzheimer's Disease: A Review of Animal Studies. Chinese Journal of Integrative Medicine. PMID 32318906 DOI: 10.1007/s11655-020-3092-9   
2020 Esteras N, Kundel F, Amodeo GF, Pavlov EV, Klenerman D, Abramov AY. Insoluble tau aggregates induce neuronal death through modification of membrane ion conductance, activation of voltage-gated calcium channels and NADPH oxidase. The Febs Journal. PMID 32338825 DOI: 10.1111/febs.15340   
2020 Husna Ibrahim N, Yahaya MF, Mohamed W, Teoh SL, Hui CK, Kumar J. Pharmacotherapy of Alzheimer's Disease: Seeking Clarity in a Time of Uncertainty. Frontiers in Pharmacology. 11: 261. PMID 32265696 DOI: 10.3389/fphar.2020.00261   
2020 Hassan SA, Kadry MO. Neurodegenerative and Hepatorenal Disorders Induced Via Aluminum Chloride in Murine System: Impact of β-Secretase, MAPK, and KIM. Biological Trace Element Research. PMID 32279189 DOI: 10.1007/s12011-020-02132-9   
2020 Mavroudis I, Petridis F, Chatzikonstantinou S, Kazis D. Alpha-synuclein Levels in the Differential Diagnosis of Lewy Bodies Dementia and Other Neurodegenerative Disorders: A Meta-analysis. Alzheimer Disease and Associated Disorders. PMID 32341240 DOI: 10.1097/WAD.0000000000000381   
2020 Sun J, Yuan B, Wu Y, Gong Y, Guo W, Fu S, Luan Y, Wang W. Sodium Butyrate Protects N2a Cells against A Toxicity In Vitro. Mediators of Inflammation. 2020: 7605160. PMID 32377164 DOI: 10.1155/2020/7605160   
2020 Dong YT, Cao K, Xiang J, Shan L, Guan ZZ. SIRT1 attenuates the neurotoxicity associated with Alzheimer's disease, via a mechanism which may involve regulation of peroxisome proliferator-activated receptor γ coactivator 1-α. The American Journal of Pathology. PMID 32289286 DOI: 10.1016/j.ajpath.2020.03.015   
2020 Walsh DM, Selkoe DJ. Amyloid β-protein and beyond: the path forward in Alzheimer's disease. Current Opinion in Neurobiology. 61: 116-124. PMID 32197217 DOI: 10.1016/j.conb.2020.02.003   
2020 Ren P, Chen J, Li B, Zhang M, Yang B, Guo X, Chen Z, Cheng H, Wang P, Wang S, Wang N, Zhang G, Wu X, Ma D, Guan D, et al. Nrf2 Ablation Promotes Alzheimer's Disease-Like Pathology in APP/PS1 Transgenic Mice: The Role of Neuroinflammation and Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2020: 3050971. PMID 32454936 DOI: 10.1155/2020/3050971   
2020 Park H, Kam TI, Dawson TM, Dawson VL. Poly (ADP-ribose) (PAR)-dependent cell death in neurodegenerative diseases. International Review of Cell and Molecular Biology. 353: 1-29. PMID 32381174 DOI: 10.1016/bs.ircmb.2019.12.009   
2020 Topçu G, Akdemir A, Kolak U, Öztürk M, Boğa M, Bahadori F, Çakmar SDH. Anticholinesterase and Antioxidant Activities of Natural Abietane Diterpenoids with Molecular Docking Studies. Current Alzheimer Research. PMID 32329687 DOI: 10.2174/1567205017666200424133534   
2020 Klementieva O, Sandt C, Martinsson I, Kansiz M, Gouras GK, Borondics F. Super-Resolution Infrared Imaging of Polymorphic Amyloid Aggregates Directly in Neurons. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). 7: 1903004. PMID 32195099 DOI: 10.1002/advs.201903004   
2020 Arora S, Sharma D, Singh J. GLUT-1 an effective target to deliver BDNF gene across blood brain barrier. Acs Chemical Neuroscience. PMID 32352752 DOI: 10.1021/acschemneuro.0c00076   
2020 Iba M, Kim C, Florio J, Mante M, Adame A, Rockenstein E, Kwon S, Rissman R, Masliah E. Role of Alterations in Protein Kinase p38γ in the Pathogenesis of the Synaptic Pathology in Dementia With Lewy Bodies and α-Synuclein Transgenic Models. Frontiers in Neuroscience. 14: 286. PMID 32296304 DOI: 10.3389/fnins.2020.00286   
2020 Xu XD, Teng Y, Zou JY, Ye Y, Song H, Wang ZY. Effects of lycopene on vascular remodeling through the LXR-PI3K-AKT signaling pathway in APP/PS1 mice. Biochemical and Biophysical Research Communications. PMID 32253029 DOI: 10.1016/j.bbrc.2020.02.063   
2020 Chen Y, Bian Y, Wang JW, Gong TT, Ying YM, Ma LF, Shan WG, Xie XQ, Zhan ZJ. Effects of α-Mangostin Derivatives on the Alzheimer's Disease Model of Rats and Their Mechanism: A Combination of Experimental Study and Computational Systems Pharmacology Analysis. Acs Omega. 5: 9846-9863. PMID 32391472 DOI: 10.1021/acsomega.0c00057   
2020 Wang X, Zhang R, Lin Y, Shi P. Inhibition of NF-κB might enhance the protective role of roflupram on SH-SY5Y cells under amyloid β stimulation via PI3K/AKT/mTOR signaling pathway. The International Journal of Neuroscience. 1-13. PMID 32314929 DOI: 10.1080/00207454.2020.1759588   
2020 Ferreiro E, Lanzillo M, Canhoto D, Carvalho da Silva AM, Mota SI, Dias IS, Ferreira IL, Fontes AR, Mastrella G, Pinheiro P, Valero J, Rego AC. Chronic hyperglycemia impairs hippocampal neurogenesis and memory in an Alzheimer's disease mouse model. Neurobiology of Aging. 92: 98-113. PMID 32417750 DOI: 10.1016/j.neurobiolaging.2020.04.003   
2020 Wu L, Zheng Q, Guo YY, Zhang KN, Luo J, Xiao S, Li WJ, Yang M. Effect of Zhenxin Xingshui Yizhi Fang on Aβ induced expression of related transporters in HBMEC cell model. Journal of Ethnopharmacology. 112783. PMID 32240783 DOI: 10.1016/j.jep.2020.112783   
2020 Quintana DD, Garcia JA, Anantula Y, Rellick SL, Engler-Chiurazzi EB, Sarkar SN, Brown CM, Simpkins JW. Amyloid-β Causes Mitochondrial Dysfunction via a Ca2+-Driven Upregulation of Oxidative Phosphorylation and Superoxide Production in Cerebrovascular Endothelial Cells. Journal of Alzheimer's Disease : Jad. PMID 32250296 DOI: 10.3233/JAD-190964   
2020 Gupta SP, Patil VM. Recent Studies on Design and Development of Drugs Against Alzheimer's Disease (AD) Based on Inhibition of BACE-1 and Other AD-causative Agents. Current Topics in Medicinal Chemistry. PMID 32297584 DOI: 10.2174/1568026620666200416091623   
2020 Amponsah AE, Feng B, Guo R, Zhang W, He J, Kong D, Dong T, Ma J, Cui H. Fragmentation of brain apolipoprotein E (ApoE) and its relevance in Alzheimer's disease. Reviews in the Neurosciences. PMID 32364519 DOI: 10.1515/revneuro-2019-0115   
2020 Singh T, Yadav S. Role of microRNAs in neurodegeneration induced by environmental neurotoxicants and aging. Ageing Research Reviews. 101068. PMID 32283224 DOI: 10.1016/j.arr.2020.101068   
2020 Moss DE. Improving Anti-Neurodegenerative Benefits of Acetylcholinesterase Inhibitors in Alzheimer's Disease: Are Irreversible Inhibitors the Future? International Journal of Molecular Sciences. 21. PMID 32414155 DOI: 10.3390/ijms21103438   
2020 Novak G, Streffer JR, Timmers M, Henley D, Brashear HR, Bogert J, Russu A, Janssens L, Tesseur I, Tritsmans L, Van Nueten L, Engelborghs S. Long-term safety and tolerability of atabecestat (JNJ-54861911), an oral BACE1 inhibitor, in early Alzheimer's disease spectrum patients: a randomized, double-blind, placebo-controlled study and a two-period extension study. Alzheimer's Research & Therapy. 12: 58. PMID 32410694 DOI: 10.1186/s13195-020-00614-5   
2020 Guo M, Wang J, Zhao Y, Feng Y, Han S, Dong Q, Cui M, Tieu K. Microglial exosomes facilitate α-synuclein transmission in Parkinson's disease. Brain : a Journal of Neurology. PMID 32355963 DOI: 10.1093/brain/awaa090   
2020 Flores-Muñoz C, Gómez B, Mery E, Mujica P, Gajardo I, Córdova C, Lopez-Espíndola D, Durán-Aniotz C, Hetz C, Muñoz P, Gonzalez-Jamett AM, Ardiles ÁO. Acute Pannexin 1 Blockade Mitigates Early Synaptic Plasticity Defects in a Mouse Model of Alzheimer's Disease. Frontiers in Cellular Neuroscience. 14: 46. PMID 32265655 DOI: 10.3389/fncel.2020.00046   
2020 Wang F, Wang F, Chen T. Secondary metabolites of from ameliorate cognitive deficits and brain oxidative stress in D-galactose induced Alzheimer's disease mouse model. Natural Product Research. 1-6. PMID 32292060 DOI: 10.1080/14786419.2020.1753738   
2020 Uddin MS, Tewari D, Sharma G, Kabir MT, Barreto GE, Bin-Jumah MN, Perveen A, Abdel-Daim MM, Ashraf GM. Molecular Mechanisms of ER Stress and UPR in the Pathogenesis of Alzheimer's Disease. Molecular Neurobiology. PMID 32430843 DOI: 10.1007/s12035-020-01929-y   
2020 Kou X, Chen D, Chen N. The Regulation of microRNAs in Alzheimer's Disease. Frontiers in Neurology. 11: 288. PMID 32362867 DOI: 10.3389/fneur.2020.00288   
2020 Oikari LE, Pandit R, Stewart R, Cuní-López C, Quek H, Sutharsan R, Rantanen LM, Oksanen M, Lehtonen S, de Boer CM, Polo JM, Götz J, Koistinaho J, White AR. Altered Brain Endothelial Cell Phenotype from a Familial Alzheimer Mutation and Its Potential Implications for Amyloid Clearance and Drug Delivery. Stem Cell Reports. PMID 32275861 DOI: 10.1016/j.stemcr.2020.03.011