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Mark E. Obrenovich, PhD - Publications

Affiliations: 
Pathology Case Western Reserve University, Cleveland Heights, OH, United States 
Website:
http://www.biomedexperts.com/Profile.bme/1036677/Mark_E_Obrenovich
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54 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Obrenovich M, Singh SK, Li Y, Perry G, Siddiqui B, Haq W, Reddy VP. Natural Product Co-Metabolism and the Microbiota-Gut-Brain Axis in Age-Related Diseases. Life (Basel, Switzerland). 13. PMID 36675988 DOI: 10.3390/life13010041  0.588
2020 Obrenovich M, Jaworski H, Tadimalla T, Mistry A, Sykes L, Perry G, Bonomo RA. The Role of the Microbiota-Gut-Brain Axis and Antibiotics in ALS and Neurodegenerative Diseases. Microorganisms. 8. PMID 32456229 DOI: 10.3390/microorganisms8050784  0.541
2020 Obrenovich M, Tabrez S, Siddiqui B, McCloskey B, Perry G. The Microbiota-Gut-Brain Axis-Heart Shunt Part II: Prosaic Foods and the Brain-Heart Connection in Alzheimer Disease. Microorganisms. 8. PMID 32244373 DOI: 10.3390/microorganisms8040493  0.542
2020 Reddy VP, Aryal P, Robinson S, Rafiu R, Obrenovich M, Perry G. Polyphenols in Alzheimer's Disease and in the Gut-Brain Axis. Microorganisms. 8. PMID 32023969 DOI: 10.3390/microorganisms8020199  0.597
2019 Jaskiw GE, Obrenovich ME, Donskey CJ. The phenolic interactome and gut microbiota: opportunities and challenges in developing applications for schizophrenia and autism. Psychopharmacology. PMID 31197432 DOI: 10.1007/S00213-019-05267-3  0.308
2019 Jones L, Kumar J, Mistry A, Sankar Chittoor Mana T, Perry G, Reddy VP, Obrenovich M. The Transformative Possibilities of the Microbiota and Mycobiota for Health, Disease, Aging, and Technological Innovation. Biomedicines. 7. PMID 30925795 DOI: 10.3390/Biomedicines7020024  0.579
2016 Obrenovich M, Flückiger R, Sykes L, Donskey C. The Co-Metabolism within the Gut-Brain Metabolic Interaction: Potential Targets for Drug Treatment and Design. Cns & Neurological Disorders Drug Targets. 15: 127-34. PMID 26831263 DOI: 10.2174/1871527315666160202123107  0.321
2013 Aliev G, Obrenovich ME, Tabrez S, Jabir NR, Reddy VP, Li Y, Burnstock G, Cacabelos R, Kamal MA. Link between cancer and Alzheimer disease via oxidative stress induced by nitric oxide-dependent mitochondrial DNA overproliferation and deletion. Oxidative Medicine and Cellular Longevity. 2013: 962984. PMID 23691268 DOI: 10.1155/2013/962984  0.406
2012 Aliev G, Obrenovich M, Bragin V. P2-128: Mitochondrion-dependent oxidative stress in the context of neurodegeneration and cancer: Recent advance Alzheimer's & Dementia. 8: P305-P305. DOI: 10.1016/j.jalz.2012.05.833  0.33
2012 Aliev G, Li Y, Palacios HH, Obrenovich ME, Bragin V, Bragin I, Shevtsova E, Klochkov SG, Kosenko EA, Kaminsky YG, Bachurin SO, Cacabelos R. Atherosclerotic lesions and mitochondrial dna deletions as a primary hallmark of the brain microcirculation - Implication in the pathogenesis of Alzheimer's disease Systems Biology of Free Radicals and Antioxidants. 2127-2145. DOI: 10.1007/978-3-642-30018-9_203  0.361
2011 Aliev G, Li Y, Palacios HH, Obrenovich ME. Oxidative stress induced mitochondrial DNA deletion as a hallmark for the drug development in the context of the cerebrovascular diseases. Recent Patents On Cardiovascular Drug Discovery. 6: 222-41. PMID 21906026 DOI: 10.2174/157489011797376942  0.5
2011 Obrenovich ME, Shamberger RJ, Lonsdale D. Altered heavy metals and transketolase found in autistic spectrum disorder. Biological Trace Element Research. 144: 475-86. PMID 21755304 DOI: 10.1007/S12011-011-9146-2  0.329
2011 Horecký J, Gvozdjáková A, Kucharská J, Obrenovich ME, Palacios HH, Li Y, Vančová O, Aliev G. Effects of coenzyme Q and creatine supplementation on brain energy metabolism in rats exposed to chronic cerebral hypoperfusion. Current Alzheimer Research. 8: 868-75. PMID 21592049 DOI: 10.2174/156720511798192727  0.363
2011 Sieradzki A, Yendluri BB, Palacios HH, Parvathaneni K, Reddy VP, Obrenovich ME, GÄ…siorowski K, Leszek J, Aliev G. Implication of oncogenic signaling pathways as a treatment strategy for neurodegenerative disorders - contemporary approaches. Cns & Neurological Disorders Drug Targets. 10: 175-83. PMID 21222633 DOI: 10.2174/187152711794480410  0.404
2011 Palacios HH, Yendluri BB, Parvathaneni K, Shadlinski VB, Obrenovich ME, Leszek J, Gokhman D, GÄ…siorowski K, Bragin V, Aliev G. Mitochondrion-specific antioxidants as drug treatments for Alzheimer disease. Cns & Neurological Disorders Drug Targets. 10: 149-62. PMID 21222631 DOI: 10.2174/187152711794480474  0.402
2011 Obrenovich ME, Gasiorowski K, Palacios HH, Gokhman D, Shadlinski VB, Bragin V, Leszek J, Aliev G. Selective loss of GRK2 regulation and its consequences: Cerebrovascular complications and alzheimer disease | Wybiórczy ubytek w zakresie regulacji GRK2 i jego konsekwencje: Powikłania naczyniowo-mózgowe i choroba alzheimera Psychogeriatria Polska. 8: 81-98.  0.327
2011 Aliev G, Palacios HH, Obrenovich ME, Gokhman D, Gasiorowski K, Bragin V, Herrera AS. Oxidative stress induced vascular hypoperfusion, mitochondrial failure are missing links for the development of Alzheimer disease Vascular Dementia: Risk Factors, Diagnosis and Treatment. 49-78.  0.349
2011 Aliev G, Palacios HH, Herrera AS, Obrenovich ME. GRK2 Overexpression is a primary hallmark of vascular hypoperfusion and mitochondrial lesions during early Alzheimer disease: New target for drug treatment? Vascular Dementia: Risk Factors, Diagnosis and Treatment. 79-103.  0.308
2010 Aliev G, Palacios HH, Gasimov E, Obrenovich ME, Morales L, Leszek J, Bragin V, Solís Herrera A, Gokhman D. Oxidative Stress Induced Mitochondrial Failure and Vascular Hypoperfusion as a Key Initiator for the Development of Alzheimer Disease. Pharmaceuticals (Basel, Switzerland). 3: 158-187. PMID 27713247 DOI: 10.3390/Ph3010158  0.511
2010 Obrenovich ME, Nair NG, Beyaz A, Aliev G, Reddy VP. The role of polyphenolic antioxidants in health, disease, and aging. Rejuvenation Research. 13: 631-43. PMID 20818981 DOI: 10.1089/Rej.2010.1043  0.383
2010 Aliev G, Palacios HH, Gasimov E, Obrenovich ME, Morales L, Leszek J, Bragin V, Herrera AS, Gokhman D. Oxidative stress induced mitochondrial failure and vascular hypoperfusion as a key initiator for the development of alzheimer disease Pharmaceuticals. 3: 158-187. DOI: 10.3390/ph3010158  0.352
2010 Aliev G, Palacios HH, Gasimov E, Gokhman D, Leszek J, Morales L, Obrenovich ME, Bragin V, Herrera AS. P3-440: Oxidative stress-induced mitochondrial failure and brain hypometabolism underlay the pathophysiology of Alzheimer's disease and offer target for treatment: Astonishing effect of melanin and mitochondrial antioxidants Alzheimer's & Dementia. 6: S582-S582. DOI: 10.1016/J.Jalz.2010.05.1982  0.453
2010 Aliev G, Palacios HH, Gasimov E, Gokhman D, Leszek J, Obrenovich ME, Bragin V, Herrera AS. P3-430: Targeting oxidative stress-induced brain hypometabolism and brain mitochondrial failure as new and effective strategies for the prevention and treatment of cognitive decline in elderly demented/depressed patients and those with Alzheimer's disease Alzheimer's & Dementia. 6: S579-S579. DOI: 10.1016/J.Jalz.2010.05.1973  0.444
2009 Obrenovich ME, Palacios HH, Gasimov E, Leszek J, Aliev G. The GRK2 Overexpression Is a Primary Hallmark of Mitochondrial Lesions during Early Alzheimer Disease. Cardiovascular Psychiatry and Neurology. 2009: 327360. PMID 20204079 DOI: 10.1155/2009/327360  0.52
2009 Aliev G, Palacios HH, Walrafen B, Lipsitt AE, Obrenovich ME, Morales L. Brain mitochondria as a primary target in the development of treatment strategies for Alzheimer disease. The International Journal of Biochemistry & Cell Biology. 41: 1989-2004. PMID 19703659 DOI: 10.1016/J.Biocel.2009.03.015  0.548
2009 Aliev G, Palacios HH, Lipsitt AE, Fischbach K, Lamb BT, Obrenovich ME, Morales L, Gasimov E, Bragin V. Nitric oxide as an initiator of brain lesions during the development of Alzheimer disease. Neurotoxicity Research. 16: 293-305. PMID 19526276 DOI: 10.1007/S12640-009-9066-5  0.503
2009 Shenk JC, Liu J, Fischbach K, Xu K, Puchowicz M, Obrenovich ME, Gasimov E, Alvarez LM, Ames BN, Lamanna JC, Aliev G. The effect of acetyl-L-carnitine and R-alpha-lipoic acid treatment in ApoE4 mouse as a model of human Alzheimer's disease. Journal of the Neurological Sciences. 283: 199-206. PMID 19342064 DOI: 10.1016/J.Jns.2009.03.002  0.416
2009 Obrenovich ME, Morales LA, Cobb CJ, Shenk JC, Méndez GM, Fischbach K, Smith MA, Qasimov EK, Perry G, Aliev G. Insights into cerebrovascular complications and Alzheimer disease through the selective loss of GRK2 regulation. Journal of Cellular and Molecular Medicine. 13: 853-65. PMID 19292735 DOI: 10.1111/J.1582-4934.2008.00512.X  0.689
2009 Aliev G, Liu J, Shenk JC, Fischbach K, Pacheco GJ, Chen SG, Obrenovich ME, Ward WF, Richardson AG, Smith MA, Gasimov E, Perry G, Ames BN. Neuronal mitochondrial amelioration by feeding acetyl-L-carnitine and lipoic acid to aged rats. Journal of Cellular and Molecular Medicine. 13: 320-33. PMID 18373733 DOI: 10.1111/J.1582-4934.2008.00324.X  0.595
2009 Aliev G, Shenk J, Liu J, Puchowicz M, Xu K, Smith M, Siedlak S, Obrenovich M, Ames B, de la Torre J, Koistinaho J, LaManna J, Perry G. Preventative effect of mitochondrial antioxidants in apoe deficiency mouse model of brain hypoperfusion Journal of the Neurological Sciences. 283: 272. DOI: 10.1016/J.Jns.2009.02.126  0.615
2009 Aliev G, Liu J, Lipsitt A, Fischbach K, Obrenovich ME, Ames BN, Qasimov E, LaManna JC, Morales L, Bragin V. O4-02-03: Preventing cognitive decline in elderly demented/depressed patients and in ApoE4 mouse as a model of human Alzheimer's disease by feeding acetyl-l-carnitine and lipoic acid Alzheimer's & Dementia. 5: P152-P152. DOI: 10.1016/J.Jalz.2009.05.524  0.343
2009 Aliev G, Daza J, Lipsitt A, Martínez-Agüero M, Palacios HH, Fischbach K, Obrenovich ME, LaManna JC, Bragin V, Morales L. P2-217: Silver nanoparticles as alternate strategies for drug delivery to Alzheimer brain Alzheimer's & Dementia. 5: P324-P324. DOI: 10.1016/J.Jalz.2009.04.530  0.311
2009 Aliev G, Palacios HH, Pacheco GJ, Gasimov E, Morales L, Gokhman D, Obrenovich ME, Bragin V, Soils A, Leszek J. Oxidative stress induced mitochondrial failure and cellular hypoperfusion: Implication in the pathogenesis of Alzheimer disease Psychogeriatria Polska. 6: 155-179.  0.354
2008 Aliev G, Obrenovich ME, Reddy VP, Shenk JC, Moreira PI, Nunomura A, Zhu X, Smith MA, Perry G. Antioxidant therapy in Alzheimer's disease: theory and practice. Mini Reviews in Medicinal Chemistry. 8: 1395-406. PMID 18991755 DOI: 10.2174/138955708786369582  0.753
2008 Aliev G, Gasimov E, Obrenovich ME, Fischbach K, Shenk JC, Smith MA, Perry G. Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels: implication in the pathogenesis of Alzheimer's disease. Vascular Health and Risk Management. 4: 721-30. PMID 18827923 DOI: 10.2147/Vhrm.S2608  0.694
2008 Aliev G, Liu J, Puchowicz M, Xu K, Siedlak S, Obrenovich M, Shenk J, Smith M, Gasimov E, LaManna J, Ames B, Perry G. DOES THE OXIDATIVE STRESS AND CEREBRAL ATHEROSCLEROSIS INITIATE BRAIN HYPOPERFUSION AND THE DEVELOPMENT OF ALZHEIMER DISEASE? Atherosclerosis Supplements. 9: 154. DOI: 10.1016/S1567-5688(08)70622-6  0.586
2007 Aliev G, Perry G, Shenk J, Puchowicz M, Xu K, Siedlak S, Obrenovich M, Smith M, Friedland R, Chen S, Ames B, Liu J, DeLaTore J, LaManna J, Koistinaho J. PO13-357 THE PRIMARY PATHOGENETIC ROLE OF VASCULAR HYPOPERFUSION, AND OXIDATIVE STRESS IN ALZHEIMER DISEASE Atherosclerosis Supplements. 8: 105. DOI: 10.1016/S1567-5688(07)71367-3  0.621
2006 Obrenovich ME, Smith MA, Siedlak SL, Chen SG, de la Torre JC, Perry G, Aliev G. Overexpression of GRK2 in Alzheimer disease and in a chronic hypoperfusion rat model is an early marker of brain mitochondrial lesions. Neurotoxicity Research. 10: 43-56. PMID 17000469 DOI: 10.1007/Bf03033333  0.673
2006 Webber KM, Casadesus G, Zhu X, Obrenovich ME, Atwood CS, Perry G, Bowen RL, Smith MA. The cell cycle and hormonal fluxes in Alzheimer disease: a novel therapeutic target. Current Pharmaceutical Design. 12: 691-7. PMID 16472159 DOI: 10.2174/138161206775474305  0.784
2006 Raina AK, Garrett MR, Previll LA, Obrenovich ME, Hartzler AW, Webber KM, Casadesus G, Lee HG, Perry G, Zhu X, Smith MA. Oncogenic parallels in Alzheimer disease International Journal of Neuroprotection and Neuroregeneration. 2: 80-85.  0.734
2004 Seyidova D, Aliyev A, Rzayev N, Obrenovich M, Lamb BT, Smith MA, de la Torre JC, Perry G, Aliev G. The role of nitric oxide in the pathogenesis of brain lesions during the development of Alzheimer's disease. In Vivo (Athens, Greece). 18: 325-33. PMID 15341188  0.646
2004 Aliyev A, Seyidova D, Rzayev N, Obrenovich ME, Lamb BT, Chen SG, Smith MA, Perry G, de la Torre JC, Aliev G. Is nitric oxide a key target in the pathogenesis of brain lesions during the development of Alzheimer's disease? Neurological Research. 26: 547-53. PMID 15265272 DOI: 10.1179/01610425017613  0.679
2004 Obrenovich ME, Monnier VM. Glycation stimulates amyloid formation. Science of Aging Knowledge Environment : Sage Ke. 2004: pe3. PMID 14724325 DOI: 10.1126/Sageke.2004.2.Pe3  0.359
2003 Aliev G, Smith MA, Obrenovich ME, de la Torre JC, Perry G. Role of vascular hypoperfusion-induced oxidative stress and mitochondria failure in the pathogenesis of Azheimer disease. Neurotoxicity Research. 5: 491-504. PMID 14715433 DOI: 10.1007/Bf03033159  0.724
2003 Aliev G, Obrenovich ME, Seyidova D, Rzayev NM, Aliyev AS, Raina AK, Lamanna JC, Smith MA, Perry G. X-ray contrast media induce aortic endothelial damage, which can be prevented with prior heparin treatment. Journal of Submicroscopic Cytology and Pathology. 35: 253-66. PMID 14690173  0.487
2003 Aliev G, Seyidova D, Lamb BT, Obrenovich ME, Siedlak SL, Vinters HV, Friedland RP, LaManna JC, Smith MA, Perry G. Mitochondria and vascular lesions as a central target for the development of Alzheimer's disease and Alzheimer disease-like pathology in transgenic mice. Neurological Research. 25: 665-74. PMID 14503022 DOI: 10.1179/016164103101201977  0.701
2003 Atwood CS, Obrenovich ME, Liu T, Chan H, Perry G, Smith MA, Martins RN. Amyloid-beta: a chameleon walking in two worlds: a review of the trophic and toxic properties of amyloid-beta. Brain Research. Brain Research Reviews. 43: 1-16. PMID 14499458 DOI: 10.1016/S0165-0173(03)00174-7  0.635
2003 Aliev G, Obrenovich ME, Smith MA, Perry G. Hypoperfusion, Mitochondria Failure, Oxidative Stress, and Alzheimer Disease. Journal of Biomedicine & Biotechnology. 2003: 162-163. PMID 12975531 DOI: 10.1155/S1110724303305029  0.718
2003 Ogawa O, Zhu X, Lee HG, Raina A, Obrenovich ME, Bowser R, Ghanbari HA, Castellani RJ, Perry G, Smith MA. Ectopic localization of phosphorylated histone H3 in Alzheimer's disease: a mitotic catastrophe? Acta Neuropathologica. 105: 524-8. PMID 12677454 DOI: 10.1007/S00401-003-0684-3  0.753
2002 Monnier VM, Obrenovich ME. Wake up and smell the maillard reaction. Science of Aging Knowledge Environment : Sage Ke. 2002: pe21. PMID 14603025 DOI: 10.1126/Sageke.2002.50.Pe21  0.327
2002 Reddy VP, Obrenovich ME, Atwood CS, Perry G, Smith MA. Involvement of Maillard reactions in Alzheimer disease. Neurotoxicity Research. 4: 191-209. PMID 12829400 DOI: 10.1080/1029840290007321  0.686
2002 Obrenovich ME, Joseph JA, Atwood CS, Perry G, Smith MA. Amyloid-beta: a (life) preserver for the brain. Neurobiology of Aging. 23: 1097-9. PMID 12470809 DOI: 10.1016/S0197-4580(02)00038-6  0.583
2002 Castellani R, Hirai K, Aliev G, Drew KL, Nunomura A, Takeda A, Cash AD, Obrenovich ME, Perry G, Smith MA. Role of mitochondrial dysfunction in Alzheimer's disease. Journal of Neuroscience Research. 70: 357-60. PMID 12391597 DOI: 10.1002/Jnr.10389  0.764
1999 Saxena AK, Saxena P, Wu X, Obrenovich M, Weiss MF, Monnier VM. Protein aging by carboxymethylation of lysines generates sites for divalent metal and redox active copper binding: relevance to diseases of glycoxidative stress. Biochemical and Biophysical Research Communications. 260: 332-8. PMID 10403771 DOI: 10.1006/Bbrc.1999.0898  0.327
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