Herbert Y. Meltzer, M.D. - Publications

Affiliations: 
Northwestern University Feinberg School of Medicine, Chicago, IL, United States 

248 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Taylor DL, Tiwari AK, Lieberman JA, Potkin SG, Meltzer HY, Knight J, Remington G, Müller DJ, Kennedy JL. Genetic association analysis of N-methyl-d-aspartate receptor subunit gene GRIN2B and clinical response to clozapine. Human Psychopharmacology. PMID 26876050 DOI: 10.1002/hup.2519  0.56
2016 Huang E, Zai CC, Lisoway A, Maciukiewicz M, Felsky D, Tiwari AK, Bishop JR, Ikeda M, Molero P, Ortuno F, Porcelli S, Samochowiec J, Mierzejewski P, Gao S, Crespo-Facorro B, ... ... Meltzer HY, et al. Catechol-O-methyltransferase Val158Met polymorphism and clinical response to antipsychotic treatment in schizophrenia and schizo-affective disorder patients: a meta-analysis. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). PMID 26745992 DOI: 10.1093/ijnp/pyv132  0.56
2016 Huang E, Maciukiewicz M, Zai CC, Tiwari AK, Li J, Potkin SG, Lieberman JA, Meltzer HY, Müller DJ, Kennedy JL. Preliminary evidence for association of genome-wide significant DRD2 schizophrenia risk variant with clozapine response. Pharmacogenomics. 17: 103-9. PMID 26666695 DOI: 10.2217/pgs.15.155  0.56
2016 Nomura T, Oyamada Y, Fernandes HB, Remmers CL, Xu J, Meltzer HY, Contractor A. Subchronic phencyclidine treatment in adult mice increases GABAergic transmission and LTP threshold in the hippocampus Neuropharmacology. 100: 90-97. DOI: 10.1016/j.neuropharm.2015.04.012  0.56
2015 Rajagopal L, Burgdorf JS, Moskal JR, Meltzer HY. GLYX-13 (rapastinel) ameliorates subchronic phencyclidine- and ketamine-induced declarative memory deficits in mice. Behavioural Brain Research. PMID 26632337 DOI: 10.1016/j.bbr.2015.10.060  0.56
2015 Miyauchi M, Neugebauer NM, Oyamada Y, Meltzer HY. Nicotinic receptors and lurasidone-mediated reversal of phencyclidine-induced deficit in novel object recognition. Behavioural Brain Research. PMID 26519556 DOI: 10.1016/j.bbr.2015.10.044  0.56
2015 Tiwari AK, Brandl EJ, Zai CC, Goncalves VF, Chowdhury NI, Freeman N, Lieberman JA, Meltzer HY, Kennedy JL, Müller DJ. Association of orexin receptor polymorphisms with antipsychotic-induced weight gain. The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry. 1-9. PMID 26447462 DOI: 10.3109/15622975.2015.1076173  0.56
2015 Huang M, Kwon S, Oyamada Y, Rajagopal L, Miyauchi M, Meltzer HY. Dopamine D3 receptor antagonism contributes to blonanserin-induced cortical dopamine and acetylcholine efflux and cognitive improvement. Pharmacology, Biochemistry, and Behavior. 138: 49-57. PMID 26383990 DOI: 10.1016/j.pbb.2015.09.011  0.56
2015 Horiguchi M, Miyauchi M, Neugebauer NM, Oyamada Y, Meltzer HY. Prolonged reversal of the phencyclidine-induced impairment in novel object recognition by a serotonin (5-HT)1A-dependent mechanism. Behavioural Brain Research. PMID 26342283 DOI: 10.1016/j.bbr.2015.08.040  0.56
2015 Brandl EJ, Tiwari AK, Zai CC, Nurmi EL, Chowdhury NI, Arenovich T, Sanches M, Goncalves VF, Shen JJ, Lieberman JA, Meltzer HY, Kennedy JL, Müller DJ. Genome-wide association study on antipsychotic-induced weight gain in the CATIE sample. The Pharmacogenomics Journal. PMID 26323598 DOI: 10.1038/tpj.2015.59  0.56
2015 Meltzer HY, Risinger R, Nasrallah HA, Du Y, Zummo J, Corey L, Bose A, Stankovic S, Silverman BL, Ehrich EW. A randomized, double-blind, placebo-controlled trial of aripiprazole lauroxil in acute exacerbation of schizophrenia. The Journal of Clinical Psychiatry. 76: 1085-1090. PMID 26114240 DOI: 10.4088/JCP.14m09741  0.56
2015 Meltzer HY. Attention Must Be Paid: The Association of Plasma Clozapine/NDMC Ratio With Working Memory. The American Journal of Psychiatry. 172: 502-4. PMID 26029799 DOI: 10.1176/appi.ajp.2015.15030338  0.56
2015 Younai A, Zeng BS, Meltzer HY, Scheidt KA. Enantioselective Syntheses of Heteroyohimbine Natural Products: A Unified Approach through Cooperative Catalysis. Angewandte Chemie (International Ed. in English). 54: 6900-4. PMID 25914164 DOI: 10.1002/anie.201502011  0.56
2015 Bonaccorso S, Sodhi M, Li J, Bobo WV, Chen Y, Tumuklu M, Theleritis C, Jayathilake K, Meltzer HY. The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is associated with increased body mass index and insulin resistance measures in bipolar disorder and schizophrenia. Bipolar Disorders. PMID 25874530 DOI: 10.1111/bdi.12294  0.56
2015 Malchenko S, Sredni ST, Hashimoto H, Kasai A, Nagayasu K, Xie J, Margaryan NV, Seiriki K, Lulla RR, Seftor RE, Pachman LM, Meltzer HY, Hendrix MJ, Soares MB. A mouse model of human primitive neuroectodermal tumors resulting from microenvironmentally-driven malignant transformation of orthotopically transplanted radial glial cells. Plos One. 10: e0121707. PMID 25826270 DOI: 10.1371/journal.pone.0121707  0.56
2015 Lee MA, Jayathilake K, Sim MY, Meltzer HY. Decreased serotonin2C receptor responses in male patients with schizophrenia. Psychiatry Research. 226: 308-15. PMID 25650049 DOI: 10.1016/j.psychres.2015.01.007  0.56
2015 Pouget JG, Gonçalves VF, Nurmi EL, P Laughlin C, Mallya KS, McCracken JT, Aman MG, McDougle CJ, Scahill L, Misener VL, Tiwari AK, Zai CC, Brandl EJ, Felsky D, Leung AQ, ... ... Meltzer HY, et al. Investigation of TSPO variants in schizophrenia and antipsychotic treatment outcomes. Pharmacogenomics. 16: 5-22. PMID 25560467 DOI: 10.2217/pgs.14.158  0.56
2015 Fonseka TM, Tiwari AK, Gonçalves VF, Lieberman JA, Meltzer HY, Goldstein BI, Kennedy JL, Kennedy SH, Müller DJ. The role of genetic variation across IL-1β, IL-2, IL-6, and BDNF in antipsychotic-induced weight gain. The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry. 16: 45-56. PMID 25560300 DOI: 10.3109/15622975.2014.984631  0.56
2015 Zai CC, Tiwari AK, Chowdhury NI, Brandl EJ, Shaikh SA, Freeman N, Lieberman JA, Meltzer HY, Müller DJ, Kennedy JL. Association study of GABAA α2 receptor subunit gene variants in antipsychotic-associated weight gain. Journal of Clinical Psychopharmacology. 35: 7-12. PMID 25514066 DOI: 10.1097/JCP.0000000000000261  0.56
2015 Oyamada Y, Horiguchi M, Rajagopal L, Miyauchi M, Meltzer HY. Combined serotonin (5-HT)1A agonism, 5-HT(2A) and dopamine D₂ receptor antagonism reproduces atypical antipsychotic drug effects on phencyclidine-impaired novel object recognition in rats. Behavioural Brain Research. 285: 165-75. PMID 25448429 DOI: 10.1016/j.bbr.2014.09.040  0.56
2015 Yamasaki A, Kasai A, Toi A, Kurita M, Kimoto S, Hayata-Takano A, Nakazawa T, Nagayasu K, Shintani N, Hashimoto R, Ito A, Meltzer HY, Ago Y, Waschek JA, Onaka Y, et al. Identification of the role of bone morphogenetic protein (BMP) and transforming growth factor-β (TGF-β) signaling in the trajectory of serotonergic differentiation in a rapid assay in mouse embryonic stem cells in vitro. Journal of Neurochemistry. 132: 418-28. PMID 25421849 DOI: 10.1111/jnc.12999  0.56
2015 Hagino Y, Kasai S, Fujita M, Setogawa S, Yamaura H, Yanagihara D, Hashimoto M, Kobayashi K, Meltzer HY, Ikeda K. Involvement of cholinergic system in hyperactivity in dopamine-deficient mice. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 1141-50. PMID 25367503 DOI: 10.1038/npp.2014.295  0.56
2015 Brandl EJ, Chowdhury NI, Tiwari AK, Lett TA, Meltzer HY, Kennedy JL, Müller DJ. Genetic variation in CYP3A43 is associated with response to antipsychotic medication. Journal of Neural Transmission (Vienna, Austria : 1996). 122: 29-34. PMID 25150845 DOI: 10.1007/s00702-014-1298-8  0.56
2015 Meltzer HY. Pharmacotherapy of cognition in schizophrenia Current Opinion in Behavioral Sciences. 4: 115-121. DOI: 10.1016/j.cobeha.2015.04.009  0.56
2014 Li J, Meltzer HY. A genetic locus in 7p12.2 associated with treatment resistant schizophrenia. Schizophrenia Research. 159: 333-9. PMID 25223841 DOI: 10.1016/j.schres.2014.08.018  0.56
2014 Brandl EJ, Tiwari AK, Zai CC, Chowdhury NI, Lieberman JA, Meltzer HY, Kennedy JL, Müller DJ. No evidence for a role of the peroxisome proliferator-activated receptor gamma (PPARG) and adiponectin (ADIPOQ) genes in antipsychotic-induced weight gain. Psychiatry Research. 219: 255-60. PMID 24953421 DOI: 10.1016/j.psychres.2014.05.031  0.56
2014 Dong H, Wang S, Zeng Z, Li F, Montalvo-Ortiz J, Tucker C, Akhtar S, Shi J, Meltzer HY, Rice KC, Csernansky JG. Effects of corticotrophin-releasing factor receptor 1 antagonists on amyloid-β and behavior in Tg2576 mice. Psychopharmacology. 231: 4711-22. PMID 24862368 DOI: 10.1007/s00213-014-3629-8  0.56
2014 Huang M, Felix AR, Flood DG, Bhuvaneswaran C, Hilt D, Koenig G, Meltzer HY. The novel α7 nicotinic acetylcholine receptor agonist EVP-6124 enhances dopamine, acetylcholine, and glutamate efflux in rat cortex and nucleus accumbens. Psychopharmacology. 231: 4541-51. PMID 24810107 DOI: 10.1007/s00213-014-3596-0  0.56
2014 Gagliano SA, Tiwari AK, Freeman N, Lieberman JA, Meltzer HY, Kennedy JL, Knight J, Müller DJ. Protein kinase cAMP-dependent regulatory type II beta (PRKAR2B) gene variants in antipsychotic-induced weight gain. Human Psychopharmacology. 29: 330-5. PMID 24737441 DOI: 10.1002/hup.2407  0.56
2014 Kao AC, Rojnic Kuzman M, Tiwari AK, Zivkovic MV, Chowdhury NI, Medved V, Kekin I, Zai CC, Lieberman JA, Meltzer HY, Bozina T, Bozina N, Kennedy JL, Sertic J, Müller DJ. Methylenetetrahydrofolate reductase gene variants and antipsychotic-induced weight gain and metabolic disturbances. Journal of Psychiatric Research. 54: 36-42. PMID 24725652 DOI: 10.1016/j.jpsychires.2014.03.012  0.56
2014 Meltzer HY, Lindenmayer JP, Kwentus J, Share DB, Johnson R, Jayathilake K. A six month randomized controlled trial of long acting injectable risperidone 50 and 100mg in treatment resistant schizophrenia. Schizophrenia Research. 154: 14-22. PMID 24630262 DOI: 10.1016/j.schres.2014.02.015  0.56
2014 Brandl EJ, Tiwari AK, Chowdhury NI, Zai CC, Lieberman JA, Meltzer HY, Kennedy JL, Müller DJ. Genetic variation in the GCG and in the GLP1R genes and antipsychotic-induced weight gain. Pharmacogenomics. 15: 423-31. PMID 24624910 DOI: 10.2217/pgs.13.247  0.56
2014 Chowdhury NI, Souza RP, Tiwari AK, Brandl EJ, Sicard M, Meltzer HY, Lieberman JA, Kennedy JL, Müller DJ. Investigation of melanocortin system gene variants in antipsychotic-induced weight gain. The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry. 15: 251-8. PMID 24564533 DOI: 10.3109/15622975.2013.858827  0.56
2014 Schmid CL, Streicher JM, Meltzer HY, Bohn LM. Clozapine acts as an agonist at serotonin 2A receptors to counter MK-801-induced behaviors through a βarrestin2-independent activation of Akt. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 1902-13. PMID 24531562 DOI: 10.1038/npp.2014.38  0.56
2014 Shing EC, Tiwari AK, Brandl EJ, Zai CC, Lieberman JA, Meltzer HY, Kennedy JL, Müller DJ. Fat mass- and obesity-associated (FTO) gene and antipsychotic-induced weight gain: an association study. Neuropsychobiology. 69: 59-63. PMID 24481458 DOI: 10.1159/000356231  0.56
2014 Sumiyoshi C, Ertugrul A, Anil YaÄŸcıoÄŸlu AE, Roy A, Jayathilake K, Milby A, Meltzer HY, Sumiyoshi T. Language-dependent performance on the letter fluency task in patients with schizophrenia. Schizophrenia Research. 152: 421-9. PMID 24444749 DOI: 10.1016/j.schres.2013.12.009  0.56
2014 Rajagopal L, Massey BW, Huang M, Oyamada Y, Meltzer HY. The novel object recognition test in rodents in relation to cognitive impairment in schizophrenia. Current Pharmaceutical Design. 20: 5104-14. PMID 24345269 DOI: 10.2174/1381612819666131216114240  0.56
2014 Huang M, Felix AR, Kwon S, Lowe D, Wallace T, Santarelli L, Meltzer HY. The alpha-7 nicotinic receptor partial agonist/5-HT3 antagonist RG3487 enhances cortical and hippocampal dopamine and acetylcholine release. Psychopharmacology. 231: 2199-210. PMID 24317442 DOI: 10.1007/s00213-013-3373-5  0.56
2014 Kishi T, Meltzer HY, Matsuda Y, Iwata N. Azapirone 5-HT1A receptor partial agonist treatment for major depressive disorder: systematic review and meta-analysis. Psychological Medicine. 44: 2255-69. PMID 24262766 DOI: 10.1017/S0033291713002857  0.56
2014 Gonçalves VF, Zai CC, Tiwari AK, Brandl EJ, Derkach A, Meltzer HY, Lieberman JA, Müller DJ, Sun L, Kennedy JL. A hypothesis-driven association study of 28 nuclear-encoded mitochondrial genes with antipsychotic-induced weight gain in schizophrenia. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 1347-54. PMID 24196945 DOI: 10.1038/npp.2013.312  0.56
2014 Huang M, Panos JJ, Kwon S, Oyamada Y, Rajagopal L, Meltzer HY. Comparative effect of lurasidone and blonanserin on cortical glutamate, dopamine, and acetylcholine efflux: role of relative serotonin (5-HT)2A and DA D2 antagonism and 5-HT1A partial agonism. Journal of Neurochemistry. 128: 938-49. PMID 24164459 DOI: 10.1111/jnc.12512  0.56
2014 Tiwari AK, Need AC, Lohoff FW, Zai CC, Chowdhury NI, Müller DJ, Putkonen A, Repo-Tiihonen E, Hallikainen T, YaÄŸcıoÄŸlu AE, Tiihonen J, Kennedy JL, Meltzer HY. Exome sequence analysis of Finnish patients with clozapine-induced agranulocytosis. Molecular Psychiatry. 19: 403-5. PMID 23752246 DOI: 10.1038/mp.2013.74  0.56
2014 Massey BW, Li J, Meltzer HY. Pharmacogenetics in the treatment of schizophrenia Schizophrenia: Recent Advances in Diagnosis and Treatment. 161-173. DOI: 10.1007/978-1-4939-0656-7_9  0.56
2013 Meltzer HY, Roth BL. Lorcaserin and pimavanserin: emerging selectivity of serotonin receptor subtype-targeted drugs. The Journal of Clinical Investigation. 123: 4986-91. PMID 24292660 DOI: 10.1172/JCI70678  0.56
2013 Meltzer HY, Rajagopal L, Huang M, Oyamada Y, Kwon S, Horiguchi M. Translating the N-methyl-D-aspartate receptor antagonist model of schizophrenia to treatments for cognitive impairment in schizophrenia. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 16: 2181-94. PMID 24099265 DOI: 10.1017/S1461145713000928  0.56
2013 Zai CC, Tiwari AK, Mazzoco M, de Luca V, Müller DJ, Shaikh SA, Lohoff FW, Freeman N, Voineskos AN, Potkin SG, Lieberman JA, Meltzer HY, Remington G, Kennedy JL. Association study of the vesicular monoamine transporter gene SLC18A2 with tardive dyskinesia. Journal of Psychiatric Research. 47: 1760-5. PMID 24018103 DOI: 10.1016/j.jpsychires.2013.07.025  0.56
2013 Chan LF, Zai C, Monda M, Potkin S, Kennedy JL, Remington G, Lieberman J, Meltzer HY, De Luca V. Role of ethnicity in antipsychotic-induced weight gain and tardive dyskinesia: genes or environment? Pharmacogenomics. 14: 1273-81. PMID 23930674 DOI: 10.2217/pgs.13.127  0.56
2013 Kishi T, Meltzer HY, Iwata N. Augmentation of antipsychotic drug action by azapirone 5-HT1A receptor partial agonists: a meta-analysis. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 16: 1259-66. PMID 23551924 DOI: 10.1017/S1461145713000151  0.56
2013 Horiguchi M, Meltzer HY. Blonanserin reverses the phencyclidine (PCP)-induced impairment in novel object recognition (NOR) in rats: role of indirect 5-HT(1A) partial agonism. Behavioural Brain Research. 247: 158-64. PMID 23538066 DOI: 10.1016/j.bbr.2013.03.027  0.56
2013 Lett TA, Chakravarty MM, Chakavarty MM, Felsky D, Brandl EJ, Tiwari AK, Gonçalves VF, Rajji TK, Daskalakis ZJ, Meltzer HY, Lieberman JA, Lerch JP, Mulsant BH, Kennedy JL, Voineskos AN. The genome-wide supported microRNA-137 variant predicts phenotypic heterogeneity within schizophrenia. Molecular Psychiatry. 18: 443-50. PMID 23459466 DOI: 10.1038/mp.2013.17  0.56
2013 Brandl EJ, Tiwari AK, Lett TA, Shaikh SA, Lieberman JA, Meltzer HY, Kennedy JL, Müller DJ. Exploratory study on association of genetic variation in TBC1D1 with antipsychotic-induced weight gain. Human Psychopharmacology. 28: 183-7. PMID 23364847 DOI: 10.1002/hup.2288  0.56
2013 Tiwari AK, Brandl EJ, Weber C, Likhodi O, Zai CC, Hahn MK, Lieberman JA, Meltzer HY, Kennedy JL, Müller DJ. Association of a functional polymorphism in neuropeptide Y with antipsychotic-induced weight gain in schizophrenia patients. Journal of Clinical Psychopharmacology. 33: 11-7. PMID 23277265 DOI: 10.1097/JCP.0b013e31827d145a  0.56
2013 Meltzer HY. Update on typical and atypical antipsychotic drugs. Annual Review of Medicine. 64: 393-406. PMID 23020880 DOI: 10.1146/annurev-med-050911-161504  0.56
2013 Horiguchi M, Hannaway KE, Adelekun AE, Huang M, Jayathilake K, Meltzer HY. D(1) receptor agonists reverse the subchronic phencyclidine (PCP)-induced novel object recognition (NOR) deficit in female rats. Behavioural Brain Research. 238: 36-43. PMID 23018127 DOI: 10.1016/j.bbr.2012.09.030  0.56
2013 Nowrouzi B, Souza RP, Zai C, Shinkai T, Monda M, Lieberman J, Volvaka J, Meltzer HY, Kennedy JL, De Luca V. Finite mixture regression model analysis on antipsychotics induced weight gain: investigation of the role of the serotonergic genes. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 23: 224-8. PMID 22840963 DOI: 10.1016/j.euroneuro.2012.05.008  0.56
2013 Chowdhury NI, Tiwari AK, Souza RP, Zai CC, Shaikh SA, Chen S, Liu F, Lieberman JA, Meltzer HY, Malhotra AK, Kennedy JL, Müller DJ. Genetic association study between antipsychotic-induced weight gain and the melanocortin-4 receptor gene. The Pharmacogenomics Journal. 13: 272-9. PMID 22310352 DOI: 10.1038/tpj.2011.66  0.56
2012 Basu A, Meltzer HY. Tying comparative effectiveness information to decision-making and the future of comparative effectiveness research designs: the case for antipsychotic drugs. Journal of Comparative Effectiveness Research. 1: 171-80. PMID 24237376 DOI: 10.2217/cer.12.8  0.56
2012 Meltzer HY. Serotonergic mechanisms as targets for existing and novel antipsychotics. Handbook of Experimental Pharmacology. 87-124. PMID 23129329 DOI: 10.1007/978-3-642-25761-2_4  0.56
2012 Liu Q, Ramsey TL, Meltzer HY, Massey BW, Padmanabhan S, Brennan MD. Sulfotransferase 4A1 Haplotype 1 (SULT4A1-1) Is Associated With Decreased Hospitalization Events in Antipsychotic-Treated Patients With Schizophrenia. The Primary Care Companion For Cns Disorders. 14. PMID 23106027 DOI: 10.4088/PCC.11m01293  0.56
2012 Meltzer HY. Clozapine: balancing safety with superior antipsychotic efficacy. Clinical Schizophrenia & Related Psychoses. 6: 134-44. PMID 23006238 DOI: 10.3371/CSRP.6.3.5  0.56
2012 Meltzer HY, Elkis H, Vanover K, Weiner DM, van Kammen DP, Peters P, Hacksell U. Pimavanserin, a selective serotonin (5-HT)2A-inverse agonist, enhances the efficacy and safety of risperidone, 2mg/day, but does not enhance efficacy of haloperidol, 2mg/day: comparison with reference dose risperidone, 6mg/day. Schizophrenia Research. 141: 144-52. PMID 22954754 DOI: 10.1016/j.schres.2012.07.029  0.56
2012 Need AC, McEvoy JP, Gennarelli M, Heinzen EL, Ge D, Maia JM, Shianna KV, He M, Cirulli ET, Gumbs CE, Zhao Q, Campbell CR, Hong L, Rosenquist P, Putkonen A, ... ... Meltzer HY, et al. Exome sequencing followed by large-scale genotyping suggests a limited role for moderately rare risk factors of strong effect in schizophrenia. American Journal of Human Genetics. 91: 303-12. PMID 22863191 DOI: 10.1016/j.ajhg.2012.06.018  0.56
2012 Horiguchi M, Hannaway KE, Adelekun AE, Jayathilake K, Meltzer HY. Prevention of the phencyclidine-induced impairment in novel object recognition in female rats by co-administration of lurasidone or tandospirone, a 5-HT(1A) partial agonist. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 2175-83. PMID 22739469 DOI: 10.1038/npp.2012.64  0.56
2012 Hirata Y, Zai CC, Souza RP, Lieberman JA, Meltzer HY, Kennedy JL. Association study of GRIK1 gene polymorphisms in schizophrenia: case-control and family-based studies. Human Psychopharmacology. 27: 345-51. PMID 22730074 DOI: 10.1002/hup.2233  0.56
2012 Zai GC, Zai CC, Chowdhury NI, Tiwari AK, Souza RP, Lieberman JA, Meltzer HY, Potkin SG, Müller DJ, Kennedy JL. The role of brain-derived neurotrophic factor (BDNF) gene variants in antipsychotic response and antipsychotic-induced weight gain. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 39: 96-101. PMID 22642961 DOI: 10.1016/j.pnpbp.2012.05.014  0.56
2012 Malhotra AK, Correll CU, Chowdhury NI, Müller DJ, Gregersen PK, Lee AT, Tiwari AK, Kane JM, Fleischhacker WW, Kahn RS, Ophoff RA, Meltzer HY, Lencz T, Kennedy JL. Association between common variants near the melanocortin 4 receptor gene and severe antipsychotic drug-induced weight gain. Archives of General Psychiatry. 69: 904-12. PMID 22566560 DOI: 10.1001/archgenpsychiatry.2012.191  0.56
2012 Wiebelhaus JM, Vunck SA, Meltzer HY, Porter JH. Discriminative stimulus properties of N-desmethylclozapine, the major active metabolite of the atypical antipsychotic clozapine, in C57BL/6 mice. Behavioural Pharmacology. 23: 262-70. PMID 22547022 DOI: 10.1097/FBP.0b013e3283534332  0.56
2012 Brandl EJ, Frydrychowicz C, Tiwari AK, Lett TA, Kitzrow W, Büttner S, Ehrlich S, Meltzer HY, Lieberman JA, Kennedy JL, Müller DJ, Puls I. Association study of polymorphisms in leptin and leptin receptor genes with antipsychotic-induced body weight gain. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 38: 134-41. PMID 22426215 DOI: 10.1016/j.pnpbp.2012.03.001  0.56
2012 Huang M, Horiguchi M, Felix AR, Meltzer HY. 5-HT1A and 5-HT7 receptors contribute to lurasidone-induced dopamine efflux. Neuroreport. 23: 436-40. PMID 22415605 DOI: 10.1097/WNR.0b013e328352de40  0.56
2012 Sun J, Jayathilake K, Zhao Z, Meltzer HY. Investigating association of four gene regions (GABRB3, MAOB, PAH, and SLC6A4) with five symptoms in schizophrenia. Psychiatry Research. 198: 202-6. PMID 22414661 DOI: 10.1016/j.psychres.2011.12.035  0.56
2012 Souza RP, Tiwari AK, Chowdhury NI, Ceddia RB, Lieberman JA, Meltzer HY, Kennedy JL, Müller DJ. Association study between variants of AMP-activated protein kinase catalytic and regulatory subunit genes with antipsychotic-induced weight gain. Journal of Psychiatric Research. 46: 462-8. PMID 22305490 DOI: 10.1016/j.jpsychires.2012.01.010  0.56
2012 Meltzer HY, Massey BW, Horiguchi M. Serotonin receptors as targets for drugs useful to treat psychosis and cognitive impairment in schizophrenia. Current Pharmaceutical Biotechnology. 13: 1572-86. PMID 22283753 DOI: 10.2174/138920112800784880  0.56
2012 Chen Y, Bobo WV, Watts K, Jayathilake K, Tang T, Meltzer HY. Comparative effectiveness of switching antipsychotic drug treatment to aripiprazole or ziprasidone for improving metabolic profile and atherogenic dyslipidemia: a 12-month, prospective, open-label study. Journal of Psychopharmacology (Oxford, England). 26: 1201-10. PMID 22234928 DOI: 10.1177/0269881111430748  0.56
2012 Horiguchi M, Meltzer HY. The role of 5-HT1A receptors in phencyclidine (PCP)-induced novel object recognition (NOR) deficit in rats. Psychopharmacology. 221: 205-15. PMID 22227609 DOI: 10.1007/s00213-011-2561-4  0.56
2012 Hwang R, Tiwari AK, Zai CC, Felsky D, Remington E, Wallace T, Tong RP, Souza RP, Oh G, Potkin SG, Lieberman JA, Meltzer HY, Kennedy JL. Dopamine D4 and D5 receptor gene variant effects on clozapine response in schizophrenia: replication and exploration. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 37: 62-75. PMID 22203087 DOI: 10.1016/j.pnpbp.2011.11.018  0.56
2012 Yuen EY, Li X, Wei J, Horiguchi M, Meltzer HY, Yan Z. The novel antipsychotic drug lurasidone enhances N-methyl-D-aspartate receptor-mediated synaptic responses. Molecular Pharmacology. 81: 113-9. PMID 22072817 DOI: 10.1124/mol.111.076141  0.56
2012 Tiwari AK, Zai CC, Likhodi O, Voineskos AN, Meltzer HY, Lieberman JA, Potkin SG, Remington G, Müller DJ, Kennedy JL. Association study of cannabinoid receptor 1 (CNR1) gene in tardive dyskinesia. The Pharmacogenomics Journal. 12: 260-6. PMID 21266946 DOI: 10.1038/tpj.2010.93  0.56
2012 Müller DJ, Zai CC, Sicard M, Remington E, Souza RP, Tiwari AK, Hwang R, Likhodi O, Shaikh S, Freeman N, Arenovich T, Heinz A, Meltzer HY, Lieberman JA, Kennedy JL. Systematic analysis of dopamine receptor genes (DRD1-DRD5) in antipsychotic-induced weight gain. The Pharmacogenomics Journal. 12: 156-64. PMID 20714340 DOI: 10.1038/tpj.2010.65  0.56
2012 Meltzer HY. Atypical antipsychotic drugs: The 5-HT2/DA2 ratio 5-Hydroxytryptamine in Psychiatry: a Spectrum of Ideas. DOI: 10.1093/acprof:oso/9780192620118.003.0024  0.56
2012 Meltzer HY, Arora RC. Platelet serotonin studies in affective disorders: Evidence for a serotonergic abnormality? 5-Hydroxytryptamine in Psychiatry: a Spectrum of Ideas. DOI: 10.1093/acprof:oso/9780192620118.003.0006  0.56
2011 Lett TA, Tiwari AK, Meltzer HY, Lieberman JA, Potkin SG, Voineskos AN, Kennedy JL, Müller DJ. The putative functional rs1045881 marker of neurexin-1 in schizophrenia and clozapine response. Schizophrenia Research. 132: 121-4. PMID 21890328 DOI: 10.1016/j.schres.2011.08.007  0.56
2011 De Luca V, Souza RP, Viggiano E, Sickert L, Teo C, Zai C, Tiwari AK, Müller DJ, Lieberman JA, Volavka J, Meltzer HY, Kennedy JL. Genetic interactions in the adrenergic system genes: analysis of antipsychotic-induced weight gain. Human Psychopharmacology. 26: 386-91. PMID 21823169 DOI: 10.1002/hup.1219  0.56
2011 Meltzer HY, Bonaccorso S, Bobo WV, Chen Y, Jayathilake K. A 12-month randomized, open-label study of the metabolic effects of olanzapine and risperidone in psychotic patients: influence of valproic acid augmentation. The Journal of Clinical Psychiatry. 72: 1602-10. PMID 21813074 DOI: 10.4088/JCP.10m05997  0.56
2011 Bobo WV, Bonaccorso S, Jayathilake K, Meltzer HY. Prediction of long-term metabolic effects of olanzapine and risperidone treatment from baseline body mass index in schizophrenia and bipolar disorder. Psychiatry Research. 189: 200-7. PMID 21802150 DOI: 10.1016/j.psychres.2011.07.008  0.56
2011 Wiebelhaus JM, Webster KA, Meltzer HY, Porter JH. The metabolites N-desmethylclozapine and N-desmethylolanzapine produce cross-tolerance to the discriminative stimulus of the atypical antipsychotic clozapine in C57BL/6 mice. Behavioural Pharmacology. 22: 458-67. PMID 21712711 DOI: 10.1097/FBP.0b013e328348ec4f  0.56
2011 Meltzer HY, Cucchiaro J, Silva R, Ogasa M, Phillips D, Xu J, Kalali AH, Schweizer E, Pikalov A, Loebel A. Lurasidone in the treatment of schizophrenia: a randomized, double-blind, placebo- and olanzapine-controlled study. The American Journal of Psychiatry. 168: 957-67. PMID 21676992 DOI: 10.1176/appi.ajp.2011.10060907  0.56
2011 Bobo WV, Woodward ND, Sim MY, Jayathilake K, Meltzer HY. The effect of adjunctive armodafinil on cognitive performance and psychopathology in antipsychotic-treated patients with schizophrenia/schizoaffective disorder: a randomized, double-blind, placebo-controlled trial. Schizophrenia Research. 130: 106-13. PMID 21641776 DOI: 10.1016/j.schres.2011.05.015  0.56
2011 Horiguchi M, Huang M, Meltzer HY. The role of 5-hydroxytryptamine 7 receptors in the phencyclidine-induced novel object recognition deficit in rats. The Journal of Pharmacology and Experimental Therapeutics. 338: 605-14. PMID 21558435 DOI: 10.1124/jpet.111.180638  0.56
2011 Jia P, Jayathilake K, Zhao Z, Meltzer HY. Association of FAS, a TNF-α receptor gene, with treatment resistant schizophrenia. Schizophrenia Research. 129: 211-2. PMID 21549565 DOI: 10.1016/j.schres.2011.04.013  0.56
2011 Miguel-Hidalgo JJ, Overholser JC, Jurjus GJ, Meltzer HY, Dieter L, Konick L, Stockmeier CA, Rajkowska G. Vascular and extravascular immunoreactivity for intercellular adhesion molecule 1 in the orbitofrontal cortex of subjects with major depression: age-dependent changes. Journal of Affective Disorders. 132: 422-31. PMID 21536333 DOI: 10.1016/j.jad.2011.03.052  0.56
2011 Ramsey TL, Meltzer HY, Brock GN, Mehrotra B, Jayathilake K, Bobo WV, Brennan MD. Evidence for a SULT4A1 haplotype correlating with baseline psychopathology and atypical antipsychotic response. Pharmacogenomics. 12: 471-80. PMID 21521020 DOI: 10.2217/pgs.10.205  0.56
2011 Horiguchi M, Huang M, Meltzer HY. Interaction of mGlu2/3 agonism with clozapine and lurasidone to restore novel object recognition in subchronic phencyclidine-treated rats. Psychopharmacology. 217: 13-24. PMID 21432027 DOI: 10.1007/s00213-011-2251-2  0.56
2011 Meltzer HY, Massey BW. The role of serotonin receptors in the action of atypical antipsychotic drugs. Current Opinion in Pharmacology. 11: 59-67. PMID 21420906 DOI: 10.1016/j.coph.2011.02.007  0.56
2011 Hwang R, Souza RP, Tiwari AK, Zai CC, Müller DJ, Potkin SG, Lieberman JA, Meltze HY, Kennedy JL. Gene-gene interaction analyses between NMDA receptor subunit and dopamine receptor gene variants and clozapine response. Pharmacogenomics. 12: 277-91. PMID 21332319 DOI: 10.2217/pgs.10.182  0.56
2011 Souza RP, Meltzer HY, Lieberman JA, Voineskos AN, Remington G, Kennedy JL. Prolactin as a biomarker for treatment response and tardive dyskinesia in schizophrenia subjects: old thoughts revisited from a genetic perspective. Human Psychopharmacology. 26: 21-7. PMID 21305610 DOI: 10.1002/hup.1161  0.56
2011 Meltzer HY, Horiguchi M, Massey BW. The role of serotonin in the NMDA receptor antagonist models of psychosis and cognitive impairment. Psychopharmacology. 213: 289-305. PMID 21212939 DOI: 10.1007/s00213-010-2137-8  0.56
2011 Jia P, Wang L, Meltzer HY, Zhao Z. Pathway-based analysis of GWAS datasets: effective but caution required. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 14: 567-72. PMID 21208483 DOI: 10.1017/S1461145710001446  0.56
2011 ErtuÄŸrul A, Ozdemir H, Vural A, Dalkara T, Meltzer HY, Saka E. The influence of N-desmethylclozapine and clozapine on recognition memory and BDNF expression in hippocampus. Brain Research Bulletin. 84: 144-50. PMID 21134422 DOI: 10.1016/j.brainresbull.2010.11.014  0.56
2011 Huang M, Dai J, Meltzer HY. 5-HT(2A) and 5-HT(2C) receptor stimulation are differentially involved in the cortical dopamine efflux-Studied in 5-HT(2A) and 5-HT(2C) genetic mutant mice. European Journal of Pharmacology. 652: 40-5. PMID 21118683 DOI: 10.1016/j.ejphar.2010.10.094  0.56
2011 Lee M, Jayathilake K, Dai J, Meltzer HY. Decreased plasma tryptophan and tryptophan/large neutral amino acid ratio in patients with neuroleptic-resistant schizophrenia: relationship to plasma cortisol concentration. Psychiatry Research. 185: 328-33. PMID 20699195 DOI: 10.1016/j.psychres.2010.07.013  0.56
2011 Souza RP, Rosa DV, Romano-Silva MA, Zhen M, Meltzer HY, Lieberman JA, Remington G, Kennedy JL, Wong AH. Lack of association of NALCN genetic variants with schizophrenia. Psychiatry Research. 185: 450-2. PMID 20674038 DOI: 10.1016/j.psychres.2010.07.009  0.56
2010 Sicard MN, Zai CC, Tiwari AK, Souza RP, Meltzer HY, Lieberman JA, Kennedy JL, Müller DJ. Polymorphisms of the HTR2C gene and antipsychotic-induced weight gain: an update and meta-analysis. Pharmacogenomics. 11: 1561-71. PMID 21121776 DOI: 10.2217/pgs.10.123  0.56
2010 Souza RP, Meltzer HY, Lieberman JA, Le Foll B, Kennedy JL. Influence of neurexin 1 (NRXN1) polymorphisms in clozapine response. Human Psychopharmacology. 25: 582-5. PMID 20860064 DOI: 10.1002/hup.1146  0.56
2010 Meyer RE, Salzman C, Youngstrom EA, Clayton PJ, Goodwin FK, Mann JJ, Alphs LD, Broich K, Goodman WK, Greden JF, Meltzer HY, Normand SL, Posner K, Shaffer D, Oquendo MA, et al. Suicidality and risk of suicide--definition, drug safety concerns, and a necessary target for drug development: a consensus statement. The Journal of Clinical Psychiatry. 71: e1-e21. PMID 20797373 DOI: 10.4088/JCP.10cs06070blu  0.56
2010 Tiwari AK, Rodgers JB, Sicard M, Zai CC, Likhodi O, Freeman N, Meltzer HY, Lieberman JA, Kennedy JL, Müller DJ. Association study of polymorphisms in cholecystokinin gene and its receptors with antipsychotic induced weight gain in schizophrenia patients. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 34: 1484-90. PMID 20732371 DOI: 10.1016/j.pnpbp.2010.08.009  0.56
2010 Meyer RE, Salzman C, Youngstrom EA, Clayton PJ, Goodwin FK, Mann JJ, Alphs LD, Broich K, Goodman WK, Greden JF, Meltzer HY, Normand SL, Posner K, Shaffer D, Oquendo MA, et al. Suicidality and risk of suicide--definition, drug safety concerns, and a necessary target for drug development: a brief report. The Journal of Clinical Psychiatry. 71: 1040-6. PMID 20673551 DOI: 10.4088/JCP.10cs06070ablu  0.56
2010 Zai CC, Manchia M, De Luca V, Tiwari AK, Squassina A, Zai GC, Strauss J, Shaikh SA, Freeman N, Meltzer HY, Lieberman J, Le Foll B, Kennedy JL. Association study of BDNF and DRD3 genes in schizophrenia diagnosis using matched case-control and family based study designs. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 34: 1412-8. PMID 20667458 DOI: 10.1016/j.pnpbp.2010.07.019  0.56
2010 Jia P, Wang L, Meltzer HY, Zhao Z. Common variants conferring risk of schizophrenia: a pathway analysis of GWAS data. Schizophrenia Research. 122: 38-42. PMID 20659789 DOI: 10.1016/j.schres.2010.07.001  0.56
2010 Souza RP, Remington G, Chowdhury NI, Lau MK, Voineskos AN, Lieberman JA, Meltzer HY, Kennedy JL. Association study of the GSK-3B gene with tardive dyskinesia in European Caucasians. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 20: 688-94. PMID 20605420 DOI: 10.1016/j.euroneuro.2010.05.002  0.56
2010 Zai CC, Tiwari AK, Müller DJ, De Luca V, Shinkai T, Shaikh S, Ni X, Sibony D, Voineskos AN, Meltzer HY, Lieberman JA, Potkin SG, Remington G, Kennedy JL. The catechol-O-methyl-transferase gene in tardive dyskinesia. The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry. 11: 803-12. PMID 20586531 DOI: 10.3109/15622975.2010.486043  0.56
2010 Souza RP, Ismail P, Meltzer HY, Kennedy JL. Variants in the oxytocin gene and risk for schizophrenia. Schizophrenia Research. 121: 279-80. PMID 20547038 DOI: 10.1016/j.schres.2010.04.019  0.56
2010 Souza RP, Remington G, Meltzer HY, Lieberman JA, Kennedy JL, Wong AH. Phosphodiesterase 4B genetic variants are not associated with antipsychotic-induced tardive dyskinesia. International Clinical Psychopharmacology. 25: 264-9. PMID 20436352 DOI: 10.1097/YIC.0b013e32833a5ff9  0.56
2010 Meltzer HY, Bobo WV, Lee MA, Cola P, Jayathilake K. A randomized trial comparing clozapine and typical neuroleptic drugs in non-treatment-resistant schizophrenia. Psychiatry Research. 177: 286-93. PMID 20378185 DOI: 10.1016/j.psychres.2010.02.018  0.56
2010 Tiwari AK, Zai CC, Meltzer HY, Lieberman JA, Müller DJ, Kennedy JL. Association study of polymorphisms in insulin induced gene 2 (INSIG2) with antipsychotic-induced weight gain in European and African-American schizophrenia patients. Human Psychopharmacology. 25: 253-9. PMID 20373477 DOI: 10.1002/hup.1111  0.56
2010 Souza RP, de Luca V, Remington G, Lieberman JA, Meltzer HY, Kennedy JL, Wong AH. Glial cell line-derived neurotrophic factor receptor alpha 2 (GFRA2) gene is associated with tardive dyskinesia. Psychopharmacology. 210: 347-54. PMID 20369355 DOI: 10.1007/s00213-010-1829-4  0.56
2010 Bobo WV, Jayathilake K, Lee MA, Meltzer HY. Changes in weight and body mass index during treatment with melperone, clozapine and typical neuroleptics. Psychiatry Research. 176: 114-9. PMID 20199813 DOI: 10.1016/j.psychres.2009.03.026  0.56
2010 Souza RP, de Luca V, Meltzer HY, Lieberman JA, Kennedy JL. Schizophrenia severity and clozapine treatment outcome association with oxytocinergic genes. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 13: 793-8. PMID 20196918 DOI: 10.1017/S1461145710000167  0.56
2010 Souza RP, de Luca V, Meltzer HY, Lieberman JA, Kennedy JL. Influence of serotonin 3A and 3B receptor genes on clozapine treatment response in schizophrenia. Pharmacogenetics and Genomics. 20: 274-6. PMID 20168265 DOI: 10.1097/FPC.0b013e328337ce3e  0.56
2010 Souza RP, Romano-Silva MA, Lieberman JA, Meltzer HY, MacNeil LT, Culotti JG, Kennedy JL, Wong AH. Genetic association of the GDNF alpha-receptor genes with schizophrenia and clozapine response. Journal of Psychiatric Research. 44: 700-6. PMID 20116071 DOI: 10.1016/j.jpsychires.2010.01.002  0.56
2010 Tiwari AK, Zai CC, Likhodi O, Lisker A, Singh D, Souza RP, Batra P, Zaidi SH, Chen S, Liu F, Puls I, Meltzer HY, Lieberman JA, Kennedy JL, Müller DJ. A common polymorphism in the cannabinoid receptor 1 (CNR1) gene is associated with antipsychotic-induced weight gain in Schizophrenia. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 35: 1315-24. PMID 20107430 DOI: 10.1038/npp.2009.235  0.56
2010 Girard TD, Pandharipande PP, Carson SS, Schmidt GA, Wright PE, Canonico AE, Pun BT, Thompson JL, Shintani AK, Meltzer HY, Bernard GR, Dittus RS, Ely EW. Feasibility, efficacy, and safety of antipsychotics for intensive care unit delirium: the MIND randomized, placebo-controlled trial. Critical Care Medicine. 38: 428-37. PMID 20095068 DOI: 10.1097/CCM.0b013e3181c58715  0.56
2010 Hwang R, Zai C, Tiwari A, Müller DJ, Arranz MJ, Morris AG, McKenna PJ, Munro J, Potkin SG, Lieberman JA, Meltzer HY, Kennedy JL. Effect of dopamine D3 receptor gene polymorphisms and clozapine treatment response: exploratory analysis of nine polymorphisms and meta-analysis of the Ser9Gly variant. The Pharmacogenomics Journal. 10: 200-18. PMID 20029384 DOI: 10.1038/tpj.2009.65  0.56
2010 Ou XM, Stockmeier CA, Meltzer HY, Overholser JC, Jurjus GJ, Dieter L, Chen K, Lu D, Johnson C, Youdim MB, Austin MC, Luo J, Sawa A, May W, Shih JC. A novel role for glyceraldehyde-3-phosphate dehydrogenase and monoamine oxidase B cascade in ethanol-induced cellular damage. Biological Psychiatry. 67: 855-63. PMID 20022592 DOI: 10.1016/j.biopsych.2009.10.032  0.56
2010 Novak G, Gallo A, Zai CC, Meltzer HY, Lieberman JA, Potkin SG, Voineskos AN, Remington G, Kennedy JL, Levesque D, Le Foll B. Association of the orphan nuclear receptor NR4A1 with tardive dyskinesia. Psychiatric Genetics. 20: 39-43. PMID 20010315 DOI: 10.1097/YPG.0b013e3283351221  0.56
2010 Meltzer HY, Mills R, Revell S, Williams H, Johnson A, Bahr D, Friedman JH. Pimavanserin, a serotonin(2A) receptor inverse agonist, for the treatment of parkinson's disease psychosis. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 35: 881-92. PMID 19907417 DOI: 10.1038/npp.2009.176  0.56
2010 Hirata Y, Souza RP, Lieberman JA, Meltzer HY, Kennedy JL. Lack of association between HTR4 gene polymorphisms and schizophrenia in case-control and family-based samples. Psychiatry Research. 175: 176-8. PMID 19892407 DOI: 10.1016/j.psychres.2009.08.005  0.56
2010 Snigdha S, Horiguchi M, Huang M, Li Z, Shahid M, Neill JC, Meltzer HY. Attenuation of phencyclidine-induced object recognition deficits by the combination of atypical antipsychotic drugs and pimavanserin (ACP 103), a 5-hydroxytryptamine(2A) receptor inverse agonist. The Journal of Pharmacology and Experimental Therapeutics. 332: 622-31. PMID 19864614 DOI: 10.1124/jpet.109.156349  0.56
2010 Zai CC, Tiwari AK, Basile V, de Luca V, Müller DJ, Voineskos AN, Remington G, Meltzer HY, Lieberman JA, Potkin SG, Kennedy JL. Oxidative stress in tardive dyskinesia: genetic association study and meta-analysis of NADPH quinine oxidoreductase 1 (NQO1) and Superoxide dismutase 2 (SOD2, MnSOD) genes. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 34: 50-6. PMID 19778569 DOI: 10.1016/j.pnpbp.2009.09.020  0.56
2010 Elkis H, Meltzer HY. Therapy-resistant schizophrenia Therapy-Resistant Schizophrenia. 26: 1-200. DOI: 10.1159/isbn.978–3–8055–9512–4  0.56
2010 Elkis H, Meltzer HY. Preface Advances in Biological Psychiatry. 26: vii-ix. DOI: 10.1159/000319817  0.56
2010 Meltzer HY. Role of clozapine in treatment-resistant schizophrenia Advances in Biological Psychiatry. 26: 114-128. DOI: 10.1159/000319812  0.56
2010 Bobo WV, Meltzer HY. Duration of untreated psychosis and premorbid functioning: Relationship with treatment response and treatment-resistant schizophrenia Advances in Biological Psychiatry. 26: 74-86. DOI: 10.1159/000319810  0.56
2010 De Luca V, Souza RP, Panariello F, Meltzer HY. Genetic studies in treatment-resistant schizophrenia Advances in Biological Psychiatry. 26: 52-62. DOI: 10.1159/000319808  0.56
2010 Woodward ND, Meltzer HY. Neuropsychology of treatment-resistant schizophrenia Advances in Biological Psychiatry. 26: 33-51. DOI: 10.1159/000319807  0.56
2010 Anderson AW, Hong X, Arlinghaus LR, Tumuklu M, Thornton-Wells, Hoffman RE, Park S, Meltzer HY. Magnetic resonance imaging of schizophrenia and Alzheimer's disease Ifmbe Proceedings. 27: 23-26. DOI: 10.1007/978-3-642-12020-6-6  0.56
2009 Souza RP, Tampakeras M, Basile V, Shinkai T, Rosa DV, Potkin S, Meltzer HY, Lieberman JA, Romano-Silva MA, Kennedy JL. Lack of association of GPX1 and MnSOD genes with symptom severity and response to clozapine treatment in schizophrenia subjects. Human Psychopharmacology. 24: 676-9. PMID 19946932 DOI: 10.1002/hup.1076  0.56
2009 Meltzer HY, Dritselis A, Yasothan U, Kirkpatrick P. Asenapine. Nature Reviews. Drug Discovery. 8: 843-4. PMID 19876039 DOI: 10.1038/nrd3027  0.56
2009 Zai CC, Tiwari AK, King N, De Luca V, Mueller DJ, Shaikh S, Wong GW, Meltzer HY, Lieberman JA, Kennedy JL. Association study of the gamma-aminobutyric acid type a receptor gamma2 subunit gene with schizophrenia. Schizophrenia Research. 114: 33-8. PMID 19682861 DOI: 10.1016/j.schres.2009.07.010  0.56
2009 Kaneda Y, Jayathilak K, Meltzer HY. Determinants of work outcome in schizophrenia and schizoaffective disorder: role of cognitive function. Psychiatry Research. 169: 178-9. PMID 19646764 DOI: 10.1016/j.psychres.2008.08.003  0.56
2009 Meltzer DO, Basu A, Meltzer HY. Comparative effectiveness research for antipsychotic medications: how much is enough? Health Affairs (Project Hope). 28: w794-808. PMID 19622539 DOI: 10.1377/hlthaff.28.5.w794  0.56
2009 Sickert L, Müller DJ, Tiwari AK, Shaikh S, Zai C, De Souza R, De Luca V, Meltzer HY, Lieberman JA, Kennedy JL. Association of the alpha 2A adrenergic receptor -1291C/G polymorphism and antipsychotic-induced weight gain in European-Americans. Pharmacogenomics. 10: 1169-76. PMID 19604092 DOI: 10.2217/pgs.09.43  0.56
2009 Bobo WV, Jayathilake K, Lee MA, Meltzer HY. Melperone, an aytpical antipsychotic drug with clozapine-like effect on plasma prolactin: contrast with typical neuroleptics. Human Psychopharmacology. 24: 415-22. PMID 19551763 DOI: 10.1002/hup.1036  0.56
2009 Li Z, Prus AJ, Dai J, Meltzer HY. Differential effects of M1 and 5-hydroxytryptamine1A receptors on atypical antipsychotic drug-induced dopamine efflux in the medial prefrontal cortex. The Journal of Pharmacology and Experimental Therapeutics. 330: 948-55. PMID 19491322 DOI: 10.1124/jpet.109.155663  0.56
2009 Abbas AI, Hedlund PB, Huang XP, Tran TB, Meltzer HY, Roth BL. Amisulpride is a potent 5-HT7 antagonist: relevance for antidepressant actions in vivo. Psychopharmacology. 205: 119-28. PMID 19337725 DOI: 10.1007/s00213-009-1521-8  0.56
2009 Meltzer HY. Atypical antipsychotic drugs have their merits. Lancet. 373: 1007; author reply 1. PMID 19304014 DOI: 10.1016/S0140-6736(09)60606-1  0.56
2009 De Luca V, Souza RP, Viggiano E, Zai CC, Shinkai T, Lieberman JA, Potkin SG, Meltzer HY, Remington G, Kennedy JL. MDR1 gene in tardive dyskinesia scale scores: comparison of strategies for quantitative trait haplotype analysis. Schizophrenia Research. 110: 200-1. PMID 19282152 DOI: 10.1016/j.schres.2009.01.021  0.56
2009 Kessler RM, Woodward ND, Riccardi P, Li R, Ansari MS, Anderson S, Dawant B, Zald D, Meltzer HY. Dopamine D2 receptor levels in striatum, thalamus, substantia nigra, limbic regions, and cortex in schizophrenic subjects. Biological Psychiatry. 65: 1024-31. PMID 19251247 DOI: 10.1016/j.biopsych.2008.12.029  0.56
2009 Zai CC, Tiwari AK, Basile V, De Luca V, Müller DJ, King N, Voineskos AN, Remington G, Meltzer HY, Lieberman JA, Potkin SG, Kennedy JL. Association study of tardive dyskinesia and five DRD4 polymorphisms in schizophrenia patients. The Pharmacogenomics Journal. 9: 168-74. PMID 19238168 DOI: 10.1038/tpj.2009.2  0.56
2009 Zai CC, Tiwari AK, De Luca V, Müller DJ, Bulgin N, Hwang R, Zai GC, King N, Voineskos AN, Meltzer HY, Lieberman JA, Potkin SG, Remington G, Kennedy JL. Genetic study of BDNF, DRD3, and their interaction in tardive dyskinesia. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 19: 317-28. PMID 19217756 DOI: 10.1016/j.euroneuro.2009.01.001  0.56
2009 Need AC, Ge D, Weale ME, Maia J, Feng S, Heinzen EL, Shianna KV, Yoon W, KasperaviciÅ«te D, Gennarelli M, Strittmatter WJ, Bonvicini C, Rossi G, Jayathilake K, Cola PA, ... ... Meltzer HY, et al. A genome-wide investigation of SNPs and CNVs in schizophrenia. Plos Genetics. 5: e1000373. PMID 19197363 DOI: 10.1371/journal.pgen.1000373  0.56
2009 Philibin SD, Walentiny DM, Vunck SA, Prus AJ, Meltzer HY, Porter JH. Further characterization of the discriminative stimulus properties of the atypical antipsychotic drug clozapine in C57BL/6 mice: role of 5-HT(2A) serotonergic and alpha (1) adrenergic antagonism. Psychopharmacology. 203: 303-15. PMID 18989659 DOI: 10.1007/s00213-008-1385-3  0.56
2009 Geffen Y, Nudelman A, Gil-Ad I, Rephaeli A, Huang M, Savitsky K, Klapper L, Winkler I, Meltzer HY, Weizman A. BL-1020: a novel antipsychotic drug with GABAergic activity and low catalepsy, is efficacious in a rat model of schizophrenia. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 19: 1-13. PMID 18757185 DOI: 10.1016/j.euroneuro.2008.07.002  0.56
2009 Szewczyk B, Albert PR, Burns AM, Czesak M, Overholser JC, Jurjus GJ, Meltzer HY, Konick LC, Dieter L, Herbst N, May W, Rajkowska G, Stockmeier CA, Austin MC. Gender-specific decrease in NUDR and 5-HT1A receptor proteins in the prefrontal cortex of subjects with major depressive disorder. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 12: 155-68. PMID 18561871 DOI: 10.1017/S1461145708009012  0.56
2008 Lieberman JA, Bymaster FP, Meltzer HY, Deutch AY, Duncan GE, Marx CE, Aprille JR, Dwyer DS, Li XM, Mahadik SP, Duman RS, Porter JH, Modica-Napolitano JS, Newton SS, Csernansky JG. Antipsychotic drugs: comparison in animal models of efficacy, neurotransmitter regulation, and neuroprotection. Pharmacological Reviews. 60: 358-403. PMID 18922967 DOI: 10.1124/pr.107.00107  0.56
2008 Zai CC, Romano-Silva MA, Hwang R, Zai GC, Deluca V, Müller DJ, King N, Voineskos AN, Meltzer HY, Lieberman JA, Potkin SG, Remington G, Kennedy JL. Genetic study of eight AKT1 gene polymorphisms and their interaction with DRD2 gene polymorphisms in tardive dyskinesia. Schizophrenia Research. 106: 248-52. PMID 18838251 DOI: 10.1016/j.schres.2008.08.036  0.56
2008 Meltzer HY, Brennan MD, Woodward ND, Jayathilake K. Association of Sult4A1 SNPs with psychopathology and cognition in patients with schizophrenia or schizoaffective disorder. Schizophrenia Research. 106: 258-64. PMID 18823757 DOI: 10.1016/j.schres.2008.08.029  0.56
2008 Meltzer HY. Oakley Ray, 1931-2007. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 2783-4. PMID 18787562 DOI: 10.1038/sj.npp.1301676  0.56
2008 Ayer DW, Jayathilake K, Meltzer HY. The InterSePT suicide scale for prediction of imminent suicidal behaviors. Psychiatry Research. 161: 87-96. PMID 18786729 DOI: 10.1016/j.psychres.2007.07.029  0.56
2008 Meltzer HY, Huang M. In vivo actions of atypical antipsychotic drug on serotonergic and dopaminergic systems. Progress in Brain Research. 172: 177-97. PMID 18772033 DOI: 10.1016/S0079-6123(08)00909-6  0.56
2008 Li Z, Snigdha S, Roseman AS, Dai J, Meltzer HY. Effect of muscarinic receptor agonists xanomeline and sabcomeline on acetylcholine and dopamine efflux in the rat brain; comparison with effects of 4-[3-(4-butylpiperidin-1-yl)-propyl]-7-fluoro-4H-benzo[1,4]oxazin-3-one (AC260584) and N-desmethylclozapine. European Journal of Pharmacology. 596: 89-97. PMID 18771666 DOI: 10.1016/j.ejphar.2008.08.009  0.56
2008 Meltzer HY, Sumiyoshi T. Does stimulation of 5-HT(1A) receptors improve cognition in schizophrenia? Behavioural Brain Research. 195: 98-102. PMID 18707769 DOI: 10.1016/j.bbr.2008.05.016  0.56
2008 Kinon BJ, Volavka J, Stauffer V, Edwards SE, Liu-Seifert H, Chen L, Adams DH, Lindenmayer JP, McEvoy JP, Buckley PF, Lieberman JA, Meltzer HY, Wilson DR, Citrome L. Standard and higher dose of olanzapine in patients with schizophrenia or schizoaffective disorder: a randomized, double-blind, fixed-dose study. Journal of Clinical Psychopharmacology. 28: 392-400. PMID 18626265 DOI: 10.1097/JCP.0b013e31817e63a5  0.56
2008 Souza RP, Romano-Silva MA, Lieberman JA, Meltzer HY, Wong AH, Kennedy JL. Association study of GSK3 gene polymorphisms with schizophrenia and clozapine response. Psychopharmacology. 200: 177-86. PMID 18500637 DOI: 10.1007/s00213-008-1193-9  0.56
2008 Meltzer HY, Bobo WV, Nuamah IF, Lane R, Hough D, Kramer M, Eerdekens M. Efficacy and tolerability of oral paliperidone extended-release tablets in the treatment of acute schizophrenia: pooled data from three 6-week, placebo-controlled studies. The Journal of Clinical Psychiatry. 69: 817-29. PMID 18466043  0.56
2008 Huang M, Li Z, Dai J, Shahid M, Wong EH, Meltzer HY. Asenapine increases dopamine, norepinephrine, and acetylcholine efflux in the rat medial prefrontal cortex and hippocampus. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 2934-45. PMID 18418367 DOI: 10.1038/npp.2008.20  0.56
2008 Krystal JH, Carter CS, Geschwind D, Manji HK, March JS, Nestler EJ, Zubieta JK, Charney DS, Goldman D, Gur RE, Lieberman JA, Roy-Byrne P, Rubinow DR, Anderson SA, Barondes S, ... ... Meltzer HY, et al. It is time to take a stand for medical research and against terrorism targeting medical scientists. Biological Psychiatry. 63: 725-7. PMID 18371494 DOI: 10.1016/j.biopsych.2008.03.005  0.56
2008 Meltzer HY, Bobo WV, Roy A, Jayathilake K, Chen Y, Ertugrul A, Anil YaÄŸcioÄŸlu AE, Small JG. A randomized, double-blind comparison of clozapine and high-dose olanzapine in treatment-resistant patients with schizophrenia. The Journal of Clinical Psychiatry. 69: 274-85. PMID 18232726  0.56
2008 Keefe RS, Malhotra AK, Meltzer HY, Kane JM, Buchanan RW, Murthy A, Sovel M, Li C, Goldman R. Efficacy and safety of donepezil in patients with schizophrenia or schizoaffective disorder: significant placebo/practice effects in a 12-week, randomized, double-blind, placebo-controlled trial. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 1217-28. PMID 17625502 DOI: 10.1038/sj.npp.1301499  0.56
2008 Bobo WV, Rapoport JL, Abi-Dargham A, Fatemi H, Meltzer HY, Kandel ER, Polan HJ. The Neurobiology of Schizophrenia Psychiatry: Third Edition. 1: 301-316. DOI: 10.1002/9780470515167.ch19  0.56
2008 Lieberman JA, Bymaster FP, Meltzer HY, Deutch AY, Duncan GE, Marx CE, Aprille JR, Dwyer DS, Li XM, Mahadik SP, Duman RS, Porter JH, Modica-Napolitano JS, Newton SS, Csernansky JG. Antipsychotic drugs: Comparison in animal models of efficacy, neurotransmitter regulation, and neuroprotection (Pharmacological Reviews (2002) 60, (358-403)) Pharmacological Reviews. 60: 582.  0.56
2008 Meltzer HY, Jayathilake K. Drs. Meltzer and Jayathilake reply Journal of Clinical Psychiatry. 69: 1660-1661.  0.56
2007 Elkis H, Meltzer HY. [Refractory schizophrenia]. Revista Brasileira De Psiquiatria (SãO Paulo, Brazil : 1999). 29: S41-7. PMID 18157433  0.56
2007 Kang HJ, Adams DH, Simen A, Simen BB, Rajkowska G, Stockmeier CA, Overholser JC, Meltzer HY, Jurjus GJ, Konick LC, Newton SS, Duman RS. Gene expression profiling in postmortem prefrontal cortex of major depressive disorder. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 13329-40. PMID 18045927 DOI: 10.1523/JNEUROSCI.4083-07.2007  0.56
2007 Renou J, De Luca V, Zai CC, Bulgin N, Remington G, Meltzer HY, Lieberman JA, Le Foll B, Kennedy JL. Multiple variants of the DRD3, but not BDNF gene, influence age-at-onset of schizophrenia. Molecular Psychiatry. 12: 1058-60. PMID 18043709 DOI: 10.1038/sj.mp.4002092  0.56
2007 Prus AJ, Huang M, Li Z, Dai J, Meltzer HY. The neurotensin analog NT69L enhances medial prefrontal cortical dopamine and acetylcholine efflux: potentiation of risperidone-, but not haloperidol-, induced dopamine efflux. Brain Research. 1184: 354-64. PMID 17988654 DOI: 10.1016/j.brainres.2007.09.092  0.56
2007 De Luca V, Müller DJ, Hwang R, Lieberman JA, Volavka J, Meltzer HY, Kennedy JL. HTR2C haplotypes and antipsychotics-induced weight gain: X-linked multimarker analysis. Human Psychopharmacology. 22: 463-7. PMID 17702092 DOI: 10.1002/hup.868  0.56
2007 Altamura AC, Bobo WV, Meltzer HY. Factors affecting outcome in schizophrenia and their relevance for psychopharmacological treatment. International Clinical Psychopharmacology. 22: 249-67. PMID 17690594 DOI: 10.1097/YIC.0b013e3280de2c7f  0.56
2007 Li Z, Bonhaus DW, Huang M, Prus AJ, Dai J, Meltzer HY. AC260584 (4-[3-(4-butylpiperidin-1-yl)-propyl]-7-fluoro-4H-benzo[1,4]oxazin-3-one), a selective muscarinic M1 receptor agonist, increases acetylcholine and dopamine release in rat medial prefrontal cortex and hippocampus. European Journal of Pharmacology. 572: 129-37. PMID 17628522 DOI: 10.1016/j.ejphar.2007.06.025  0.56
2007 Sumiyoshi T, Park S, Jayathilake K, Roy A, Ertugrul A, Meltzer HY. Effect of buspirone, a serotonin1A partial agonist, on cognitive function in schizophrenia: a randomized, double-blind, placebo-controlled study. Schizophrenia Research. 95: 158-68. PMID 17628435 DOI: 10.1016/j.schres.2007.06.008  0.56
2007 Keefe RS, Bilder RM, Davis SM, Harvey PD, Palmer BW, Gold JM, Meltzer HY, Green MF, Capuano G, Stroup TS, McEvoy JP, Swartz MS, Rosenheck RA, Perkins DO, Davis CE, et al. Neurocognitive effects of antipsychotic medications in patients with chronic schizophrenia in the CATIE Trial. Archives of General Psychiatry. 64: 633-47. PMID 17548746 DOI: 10.1001/archpsyc.64.6.633  0.56
2007 Sumiyoshi T, Higuchi Y, Matsui M, Arai H, Takamiya C, Meltzer HY, Kurachi M. Effective adjunctive use of tandospirone with perospirone for enhancing verbal memory and quality of life in schizophrenia. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 31: 965-7. PMID 17391821 DOI: 10.1016/j.pnpbp.2007.02.017  0.56
2007 Pompili M, Amador XF, Girardi P, Harkavy-Friedman J, Harrow M, Kaplan K, Krausz M, Lester D, Meltzer HY, Modestin J, Montross LP, Mortensen PB, Munk-Jørgensen P, Nielsen J, Nordentoft M, et al. Suicide risk in schizophrenia: learning from the past to change the future. Annals of General Psychiatry. 6: 10. PMID 17367524 DOI: 10.1186/1744-859X-6-10  0.56
2007 Kane JM, Meltzer HY, Carson WH, McQuade RD, Marcus RN, Sanchez R. Aripiprazole for treatment-resistant schizophrenia: results of a multicenter, randomized, double-blind, comparison study versus perphenazine. The Journal of Clinical Psychiatry. 68: 213-23. PMID 17335319  0.56
2007 Li Z, Huang M, Prus AJ, Dai J, Meltzer HY. 5-HT6 receptor antagonist SB-399885 potentiates haloperidol and risperidone-induced dopamine efflux in the medial prefrontal cortex or hippocampus. Brain Research. 1134: 70-8. PMID 17207474 DOI: 10.1016/j.brainres.2006.11.060  0.56
2007 Woodward ND, Jayathilake K, Meltzer HY. COMT val108/158met genotype, cognitive function, and cognitive improvement with clozapine in schizophrenia. Schizophrenia Research. 90: 86-96. PMID 17123785 DOI: 10.1016/j.schres.2006.10.002  0.56
2007 Altamura AC, Mundo E, Bassetti R, Green A, Lindenmayer JP, Alphs L, Meltzer HY. Transcultural differences in suicide attempters: analysis on a high-risk population of patients with schizophrenia or schizoaffective disorder. Schizophrenia Research. 89: 140-6. PMID 17097854 DOI: 10.1016/j.schres.2006.08.023  0.56
2007 Hwang R, Shinkai T, De Luca V, Ni X, Potkin SG, Lieberman JA, Meltzer HY, Kennedy JL. Association study of four dopamine D1 receptor gene polymorphisms and clozapine treatment response. Journal of Psychopharmacology (Oxford, England). 21: 718-27. PMID 17092969 DOI: 10.1177/0269881106072341  0.56
2007 Woodward ND, Purdon SE, Meltzer HY, Zald DH. A meta-analysis of cognitive change with haloperidol in clinical trials of atypical antipsychotics: dose effects and comparison to practice effects. Schizophrenia Research. 89: 211-24. PMID 17059880 DOI: 10.1016/j.schres.2006.08.021  0.56
2007 Marquis KL, Sabb AL, Logue SF, Brennan JA, Piesla MJ, Comery TA, Grauer SM, Ashby CR, Nguyen HQ, Dawson LA, Barrett JE, Stack G, Meltzer HY, Harrison BL, Rosenzweig-Lipson S. WAY-163909 [(7bR,10aR)-1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta-[b][1,4]diazepino[6,7,1hi]indole]: A novel 5-hydroxytryptamine 2C receptor-selective agonist with preclinical antipsychotic-like activity. The Journal of Pharmacology and Experimental Therapeutics. 320: 486-96. PMID 17038512 DOI: 10.1124/jpet.106.106989  0.56
2007 Zai CC, Hwang RW, De Luca V, Müller DJ, King N, Zai GC, Remington G, Meltzer HY, Lieberman JA, Potkin SG, Kennedy JL. Association study of tardive dyskinesia and twelve DRD2 polymorphisms in schizophrenia patients. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 10: 639-51. PMID 16959057 DOI: 10.1017/S1461145706007152  0.56
2007 McCreary AC, Glennon JC, Ashby CR, Meltzer HY, Li Z, Reinders JH, Hesselink MB, Long SK, Herremans AH, van Stuivenberg H, Feenstra RW, Kruse CG. SLV313 (1-(2,3-dihydro-benzo[1,4]dioxin-5-yl)-4- [5-(4-fluoro-phenyl)-pyridin-3-ylmethyl]-piperazine monohydrochloride): a novel dopamine D2 receptor antagonist and 5-HT1A receptor agonist potential antipsychotic drug. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 32: 78-94. PMID 16710314 DOI: 10.1038/sj.npp.1301098  0.56
2007 Kane JM, Meltzer HY, Carson WH, McQuade RD, Marcus RN, Sanchez R. Dr. Kane and colleagues reply [4] Journal of Clinical Psychiatry. 68: 1813-1814.  0.56
2006 Miguel-Hidalgo JJ, Overholser JC, Meltzer HY, Stockmeier CA, Rajkowska G. Reduced glial and neuronal packing density in the orbitofrontal cortex in alcohol dependence and its relationship with suicide and duration of alcohol dependence. Alcoholism, Clinical and Experimental Research. 30: 1845-55. PMID 17067348 DOI: 10.1111/j.1530-0277.2006.00221.x  0.56
2006 Huang M, Li Z, Ichikawa J, Dai J, Meltzer HY. Effects of divalproex and atypical antipsychotic drugs on dopamine and acetylcholine efflux in rat hippocampus and prefrontal cortex. Brain Research. 1099: 44-55. PMID 16824491 DOI: 10.1016/j.brainres.2006.04.081  0.32
2006 Keefe RS, Bilder RM, Harvey PD, Davis SM, Palmer BW, Gold JM, Meltzer HY, Green MF, Miller DD, Canive JM, Adler LW, Manschreck TC, Swartz M, Rosenheck R, Perkins DO, et al. Baseline neurocognitive deficits in the CATIE schizophrenia trial. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 2033-46. PMID 16641947 DOI: 10.1038/sj.npp.1301072  0.56
2006 McEvoy JP, Lieberman JA, Stroup TS, Davis SM, Meltzer HY, Rosenheck RA, Swartz MS, Perkins DO, Keefe RS, Davis CE, Severe J, Hsiao JK. Effectiveness of clozapine versus olanzapine, quetiapine, and risperidone in patients with chronic schizophrenia who did not respond to prior atypical antipsychotic treatment. The American Journal of Psychiatry. 163: 600-10. PMID 16585434 DOI: 10.1176/appi.ajp.163.4.600  0.56
2006 Huang M, Ichiwaka J, Li Z, Dai J, Meltzer HY. Augmentation by citalopram of risperidone-induced monoamine release in rat prefrontal cortex. Psychopharmacology. 185: 274-81. PMID 16521036 DOI: 10.1007/s00213-005-0206-1  0.32
2006 Mann JJ, Emslie G, Baldessarini RJ, Beardslee W, Fawcett JA, Goodwin FK, Leon AC, Meltzer HY, Ryan ND, Shaffer D, Wagner KD. ACNP Task Force report on SSRIs and suicidal behavior in youth. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 473-92. PMID 16319919 DOI: 10.1038/sj.npp.1300958  0.56
2006 Basu A, Meltzer HY, Dukic V. Estimating transitions between symptom severity states over time in schizophrenia: a Bayesian meta-analytic approach. Statistics in Medicine. 25: 2886-910. PMID 16220519 DOI: 10.1002/sim.2317  0.56
2005 Li Z, Ichikawa J, Huang M, Prus AJ, Dai J, Meltzer HY. ACP-103, a 5-HT2A/2C inverse agonist, potentiates haloperidol-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens. Psychopharmacology. 183: 144-53. PMID 16220333 DOI: 10.1007/s00213-005-0170-9  0.56
2005 Ichikawa J, Chung YC, Dai J, Meltzer HY. Valproic acid potentiates both typical and atypical antipsychotic-induced prefrontal cortical dopamine release. Brain Research. 1052: 56-62. PMID 16061211 DOI: 10.1016/j.brainres.2005.06.009  0.32
2005 Ichikawa J, Dai J, Meltzer HY. Lithium differs from anticonvulsant mood stabilizers in prefrontal cortical and accumbal dopamine release: role of 5-HT(1A) receptor agonism. Brain Research. 1049: 182-90. PMID 15936730 DOI: 10.1016/j.brainres.2005.05.005  0.32
2005 Li Z, Huang M, Ichikawa J, Dai J, Meltzer HY. N-desmethylclozapine, a major metabolite of clozapine, increases cortical acetylcholine and dopamine release in vivo via stimulation of M1 muscarinic receptors. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 30: 1986-95. PMID 15900318 DOI: 10.1038/sj.npp.1300768  0.32
2005 Woodward ND, Purdon SE, Meltzer HY, Zald DH. A meta-analysis of neuropsychological change to clozapine, olanzapine, quetiapine, and risperidone in schizophrenia. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 8: 457-72. PMID 15784157 DOI: 10.1017/S146114570500516X  0.56
2004 Alphs L, Anand R, Islam MZ, Meltzer HY, Kane JM, Krishnan R, Green AI, Potkin S, Chouinard G, Lindenmayer JP, Kerwin R. The international suicide prevention trial (interSePT): rationale and design of a trial comparing the relative ability of clozapine and olanzapine to reduce suicidal behavior in schizophrenia and schizoaffective patients. Schizophrenia Bulletin. 30: 577-86. PMID 15631247  0.56
2004 Stockmeier CA, Mahajan GJ, Konick LC, Overholser JC, Jurjus GJ, Meltzer HY, Uylings HB, Friedman L, Rajkowska G. Cellular changes in the postmortem hippocampus in major depression. Biological Psychiatry. 56: 640-50. PMID 15522247 DOI: 10.1016/j.biopsych.2004.08.022  0.56
2004 Ertugrul A, Kennedy JL, Masellis M, Basile VS, Jayathilake K, Meltzer HY. No association of the T102C polymorphism of the serotonin 2A receptor gene (HTR2A) with suicidality in schizophrenia. Schizophrenia Research. 69: 301-5. PMID 15469201 DOI: 10.1016/S0920-9964(03)00126-9  0.56
2004 Chung YC, Li Z, Dai J, Meltzer HY, Ichikawa J. Clozapine increases both acetylcholine and dopamine release in rat ventral hippocampus: role of 5-HT1A receptor agonism. Brain Research. 1023: 54-63. PMID 15364019 DOI: 10.1016/j.brainres.2004.07.009  0.32
2004 Bourgeois M, Swendsen J, Young F, Amador X, Pini S, Cassano GB, Lindenmayer JP, Hsu C, Alphs L, Meltzer HY. Awareness of disorder and suicide risk in the treatment of schizophrenia: results of the international suicide prevention trial. The American Journal of Psychiatry. 161: 1494-6. PMID 15285981 DOI: 10.1176/appi.ajp.161.8.1494  0.56
2004 Weiner DM, Meltzer HY, Veinbergs I, Donohue EM, Spalding TA, Smith TT, Mohell N, Harvey SC, Lameh J, Nash N, Vanover KE, Olsson R, Jayathilake K, Lee M, Levey AI, et al. The role of M1 muscarinic receptor agonism of N-desmethylclozapine in the unique clinical effects of clozapine. Psychopharmacology. 177: 207-16. PMID 15258717 DOI: 10.1007/s00213-004-1940-5  0.56
2004 Li Z, Ichikawa J, Dai J, Meltzer HY. Aripiprazole, a novel antipsychotic drug, preferentially increases dopamine release in the prefrontal cortex and hippocampus in rat brain. European Journal of Pharmacology. 493: 75-83. PMID 15189766 DOI: 10.1016/j.ejphar.2004.04.028  0.32
2004 Jaskiw GE, Hussain G, Stephans SE, Yamamoto BK, Meltzer HY. Clozapine prolongs hypotonic immobility in rats with bilateral 6-hydroxydopamine lesions of the striatum. Neuroscience Letters. 362: 35-8. PMID 15147775 DOI: 10.1016/j.neulet.2004.01.079  0.56
2004 Prus AJ, Baker LE, Meltzer HY. Discriminative stimulus properties of 1.25 and 5.0 mg/kg doses of clozapine in rats: examination of the role of dopamine, serotonin, and muscarinic receptor mechanisms. Pharmacology, Biochemistry, and Behavior. 77: 199-208. PMID 14751446 DOI: 10.1016/j.pbb.2003.10.010  0.56
2003 Meltzer HY, Li Z, Kaneda Y, Ichikawa J. Serotonin receptors: their key role in drugs to treat schizophrenia. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 27: 1159-72. PMID 14642974 DOI: 10.1016/j.pnpbp.2003.09.010  0.32
2003 Weiner DM, Vanover KE, Brann MR, Meltzer HY, Davis RE. Psychosis of Parkinson's disease: serotonin 2A receptor inverse agonists as potential therapeutics. Current Opinion in Investigational Drugs (London, England : 2000). 4: 815-9. PMID 14619402  0.56
2003 Bonaccorso S, Maier SF, Meltzer HY, Maes M. Behavioral changes in rats after acute, chronic and repeated administration of interleukin-1beta: relevance for affective disorders. Journal of Affective Disorders. 77: 143-8. PMID 14607391 DOI: 10.1016/S0165-0327(02)00118-0  0.56
2003 Keefe RS, Mohs RC, Bilder RM, Harvey PD, Green MF, Meltzer HY, Gold JM, Sano M. Neurocognitive assessment in the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) project schizophrenia trial: development, methodology, and rationale. Schizophrenia Bulletin. 29: 45-55. PMID 12908660  0.56
2003 Li Z, Kim CH, Ichikawa J, Meltzer HY. Effect of repeated administration of phencyclidine on spatial performance in an eight-arm radial maze with delay in rats and mice. Pharmacology, Biochemistry, and Behavior. 75: 335-40. PMID 12873624  0.32
2003 Jaskiw GE, Blumer TE, Gutierrez-Esteinou R, Meltzer HY, Steele V, Strauss ME. Comparison of inpatients with major mental illness who do and do not consent to low-risk research. Psychiatry Research. 119: 183-8. PMID 12860374 DOI: 10.1016/S0165-1781(03)00115-X  0.56
2003 Li Z, Ichikawa J, Meltzer HY. A comparison of the effects of loxapine with ziprasidone and thioridazine on the release of dopamine and acetylcholine in the prefrontal cortex and nucleus accumbens. Psychopharmacology. 167: 315-23. PMID 12664192 DOI: 10.1007/s00213-003-1418-x  0.32
2002 Ichikawa J, Chung YC, Li Z, Dai J, Meltzer HY. Cholinergic modulation of basal and amphetamine-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens. Brain Research. 958: 176-84. PMID 12468043  0.32
2002 Ichikawa J, Li Z, Dai J, Meltzer HY. Atypical antipsychotic drugs, quetiapine, iloperidone, and melperone, preferentially increase dopamine and acetylcholine release in rat medial prefrontal cortex: role of 5-HT1A receptor agonism. Brain Research. 956: 349-57. PMID 12445705  0.32
2002 Bonaccorso S, Meltzer HY, Li Z, Dai J, Alboszta AR, Ichikawa J. SR46349-B, a 5-HT(2A/2C) receptor antagonist, potentiates haloperidol-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 27: 430-41. PMID 12225700 DOI: 10.1016/S0893-133X(02)00311-1  0.32
2002 Stockmeier CA, Shi X, Konick L, Overholser JC, Jurjus G, Meltzer HY, Friedman L, Blier P, Rajkowska G. Neurokinin-1 receptors are decreased in major depressive disorder. Neuroreport. 13: 1223-7. PMID 12151774  0.56
2002 Lerer B, Segman RH, Fangerau H, Daly AK, Basile VS, Cavallaro R, Aschauer HN, McCreadie RG, Ohlraun S, Ferrier N, Masellis M, Verga M, Scharfetter J, Rietschel M, Lovlie R, ... ... Meltzer HY, et al. Pharmacogenetics of tardive dyskinesia: combined analysis of 780 patients supports association with dopamine D3 receptor gene Ser9Gly polymorphism. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 27: 105-19. PMID 12062911 DOI: 10.1016/S0893-133X(02)00293-2  0.56
2002 Ichikawa J, Dai J, Meltzer HY. 5-HT(1A) and 5-HT(2A) receptors minimally contribute to clozapine-induced acetylcholine release in rat medial prefrontal cortex. Brain Research. 939: 34-42. PMID 12020849  0.32
2002 Ichikawa J, Dai J, O'Laughlin IA, Fowler WL, Meltzer HY. Atypical, but not typical, antipsychotic drugs increase cortical acetylcholine release without an effect in the nucleus accumbens or striatum. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 26: 325-39. PMID 11850147 DOI: 10.1016/S0893-133X(01)00312-8  0.32
2001 Lee MA, Meltzer HY. 5-HT(1A) receptor dysfunction in female patients with schizophrenia. Biological Psychiatry. 50: 758-66. PMID 11720694 DOI: 10.1016/S0006-3223(01)01202-1  0.56
2001 Basile VS, Masellis M, McIntyre RS, Meltzer HY, Lieberman JA, Kennedy JL. Genetic dissection of atypical antipsychotic-induced weight gain: novel preliminary data on the pharmacogenetic puzzle. The Journal of Clinical Psychiatry. 62: 45-66. PMID 11603885  0.56
2001 Klimek V, Zhu MY, Dilley G, Konick L, Overholser JC, Meltzer HY, May WL, Stockmeier CA, Ordway GA. Effects of long-term cigarette smoking on the human locus coeruleus. Archives of General Psychiatry. 58: 821-7. PMID 11545664  0.56
2001 Ichikawa J, Dai J, Meltzer HY. DOI, a 5-HT2A/2C receptor agonist, attenuates clozapine-induced cortical dopamine release. Brain Research. 907: 151-5. PMID 11430898  0.32
2001 Basile VS, Ozdemir V, Masellis M, Meltzer HY, Lieberman JA, Potkin SG, Macciardi FM, Petronis A, Kennedy JL. Lack of association between serotonin-2A receptor gene (HTR2A) polymorphisms and tardive dyskinesia in schizophrenia. Molecular Psychiatry. 6: 230-4. PMID 11317228 DOI: 10.1038/sj.mp.4000847  0.56
2001 Niswender CM, Herrick-Davis K, Dilley GE, Meltzer HY, Overholser JC, Stockmeier CA, Emeson RB, Sanders-Bush E. RNA editing of the human serotonin 5-HT2C receptor. alterations in suicide and implications for serotonergic pharmacotherapy. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 24: 478-91. PMID 11282248 DOI: 10.1016/S0893-133X(00)00223-2  0.56
2001 Masellis M, Basile VS, Meltzer HY, Lieberman JA, Sevy S, Goldman DA, Hamblin MW, Macciardi FM, Kennedy JL. Lack of association between the T-->C 267 serotonin 5-HT6 receptor gene (HTR6) polymorphism and prediction of response to clozapine in schizophrenia. Schizophrenia Research. 47: 49-58. PMID 11163544 DOI: 10.1016/S0920-9964(00)00016-5  0.56
2001 Shelton RC, Tollefson GD, Tohen M, Stahl S, Gannon KS, Jacobs TG, Buras WR, Bymaster FP, Zhang W, Spencer KA, Feldman PD, Meltzer HY. A novel augmentation strategy for treating resistant major depression. The American Journal of Psychiatry. 158: 131-4. PMID 11136647 DOI: 10.1176/appi.ajp.158.1.131  0.56
2000 Miguel-Hidalgo JJ, Baucom C, Dilley G, Overholser JC, Meltzer HY, Stockmeier CA, Rajkowska G. Glial fibrillary acidic protein immunoreactivity in the prefrontal cortex distinguishes younger from older adults in major depressive disorder. Biological Psychiatry. 48: 861-73. PMID 11063981 DOI: 10.1016/S0006-3223(00)00999-9  0.56
2000 Kuroki T, Dai J, Meltzer HY, Ichikawa J. R(+)-8-OH-DPAT, a selective 5-HT(1A) receptor agonist, attenuated amphetamine-induced dopamine synthesis in rat striatum, but not nucleus accumbens or medial prefrontal cortex. Brain Research. 872: 204-7. PMID 10924694  0.32
2000 Basile VS, Ozdemir V, Masellis M, Walker ML, Meltzer HY, Lieberman JA, Potkin SG, Alva G, Kalow W, Macciardi FM, Kennedy JL. A functional polymorphism of the cytochrome P450 1A2 (CYP1A2) gene: association with tardive dyskinesia in schizophrenia. Molecular Psychiatry. 5: 410-7. PMID 10889552  0.56
2000 Vincent JB, Neves-Pereira ML, Paterson AD, Yamamoto E, Parikh SV, Macciardi F, Gurling HM, Potkin SG, Pato CN, Macedo A, Kovacs M, Davies M, Lieberman JA, Meltzer HY, Petronis A, et al. An unstable trinucleotide-repeat region on chromosome 13 implicated in spinocerebellar ataxia: a common expansion locus. American Journal of Human Genetics. 66: 819-29. PMID 10712198 DOI: 10.1086/302803  0.56
2000 Masellis M, Basile VS, Ozdemir V, Meltzer HY, Macciardi FM, Kennedy JL. Pharmacogenetics of antipsychotic treatment: lessons learned from clozapine. Biological Psychiatry. 47: 252-66. PMID 10682223 DOI: 10.1016/S0006-3223(99)00298-X  0.56
2000 Park S, Knopick C, McGurk S, Meltzer HY. Nicotine impairs spatial working memory while leaving spatial attention intact. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 22: 200-9. PMID 10649832 DOI: 10.1016/S0893-133X(99)00098-6  0.56
1999 Ordway GA, Farley JT, Dilley GE, Overholser JC, Meltzer HY, Balraj EK, Stockmeier CA, Klimek V. Quantitative distribution of monoamine oxidase A in brainstem monoamine nuclei is normal in major depression. Brain Research. 847: 71-9. PMID 10564737 DOI: 10.1016/S0006-8993(99)02043-0  0.56
1999 Zhu MY, Klimek V, Dilley GE, Haycock JW, Stockmeier C, Overholser JC, Meltzer HY, Ordway GA. Elevated levels of tyrosine hydroxylase in the locus coeruleus in major depression. Biological Psychiatry. 46: 1275-86. PMID 10560033 DOI: 10.1016/S0006-3223(99)00135-3  0.56
1999 Young CD, Bubser M, Meltzer HY, Deutch AY. Clozapine pretreatment modifies haloperidol-elicited forebrain Fos induction: a regionally-specific double dissociation. Psychopharmacology. 144: 255-63. PMID 10435392 DOI: 10.1007/s002130051001  0.56
1999 Meltzer HY. Dopamine2 receptor occupancy and the action of clozapine: does it make a difference to add a neuroleptic? Biological Psychiatry. 46: 144-9. PMID 10394487 DOI: 10.1016/S0006-3223(99)00050-5  0.56
1999 Klimek V, Rajkowska G, Luker SN, Dilley G, Meltzer HY, Overholser JC, Stockmeier CA, Ordway GA. Brain noradrenergic receptors in major depression and schizophrenia. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 21: 69-81. PMID 10379521 DOI: 10.1016/S0893-133X(98)00134-1  0.56
1999 Basile VS, Masellis M, Badri F, Paterson AD, Meltzer HY, Lieberman JA, Potkin SG, Macciardi F, Kennedy JL. Association of the MscI polymorphism of the dopamine D3 receptor gene with tardive dyskinesia in schizophrenia. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 21: 17-27. PMID 10379516 DOI: 10.1016/S0893-133X(98)00114-6  0.56
1999 Rietschel M, Kennedy JL, Macciardi F, Meltzer HY. Application of pharmacogenetics to psychotic disorders: the first consensus conference. The Consensus Group for Outcome Measures in Psychoses for Pharmacological Studies. Schizophrenia Research. 37: 191-6. PMID 10374654 DOI: 10.1016/S0920-9964(98)00153-4  0.56
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