| Year |
Citation |
Score |
| 2023 |
Nepal B, Das S, Reith ME, Kortagere S. Overview of the structure and function of the dopamine transporter and its protein interactions. Frontiers in Physiology. 14: 1150355. PMID 36935752 DOI: 10.3389/fphys.2023.1150355 |
0.395 |
|
| 2022 |
Dinda B, Das B, Biswas S, Sharma H, Armstrong C, Yedlapudi D, Antonio T, Reith M, Dutta AK. Bivalent dopamine agonists with co-operative binding and functional activities at dopamine D2 receptors, modulate aggregation and toxicity of alpha synuclein protein. Bioorganic & Medicinal Chemistry. 78: 117131. PMID 36571976 DOI: 10.1016/j.bmc.2022.117131 |
0.361 |
|
| 2022 |
Reid KM, Spaull R, Salian S, Barwick K, Meyer E, Zhen J, Hirata H, Sheipouri D, Benkerroum H, Gorman KM, Papandreou A, Simpson MA, Hirano Y, Farabella I, Topf M, ... ... Reith ME, et al. MED27, SLC6A7, and MPPE1 Variants in a Complex Neurodevelopmental Disorder with Severe Dystonia. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 35876425 DOI: 10.1002/mds.29147 |
0.421 |
|
| 2020 |
Jayaraman K, Das AK, Luethi D, Szöllősi D, Schütz GJ, Reith ME, Sitte HH, Stockner T. SLC6 transporter oligomerization. Journal of Neurochemistry. PMID 32767560 DOI: 10.1111/Jnc.15145 |
0.417 |
|
| 2017 |
Jones KT, Woods C, Zhen J, Antonio T, Carr KD, Reith ME. Effects of diet and insulin on dopamine transporter activity and expression in rat caudate-putamen, nucleus accumbens, and midbrain. Journal of Neurochemistry. 140: 728-740. PMID 27973691 DOI: 10.1111/Jnc.13930 |
0.622 |
|
| 2017 |
Xu W, Wang X, Tocker AM, Huang P, Reith ME, Liu-Chen LY, Smith AB, Kortagere S. Functional Characterization of a Novel Series of Biased Signaling Dopamine D3 Receptor Agonists. Acs Chemical Neuroscience. 8: 486-500. PMID 27801563 DOI: 10.1021/Acschemneuro.6B00221 |
0.452 |
|
| 2016 |
Madapa S, Gadhiya S, Kurtzman T, Alberts IL, Ramsey S, Reith M, Harding WW. Synthesis and evaluation of C9 alkoxy analogues of (-)-stepholidine as dopamine receptor ligands. European Journal of Medicinal Chemistry. 125: 255-268. PMID 27688181 DOI: 10.1016/J.Ejmech.2016.09.036 |
0.403 |
|
| 2016 |
Zhen J, Reith ME. Impact of disruption of secondary binding site S2 on dopamine transporter function. Journal of Neurochemistry. 138: 694-9. PMID 27315582 DOI: 10.1111/Jnc.13704 |
0.668 |
|
| 2015 |
Das B, Vedachalam S, Luo D, Antonio T, Reith ME, Dutta AK. Development of a Highly Potent D2/D3 Agonist and a Partial Agonist from Structure-Activity Relationship Study of N(6)-(2-(4-(1H-Indol-5-yl)piperazin-1-yl)ethyl)-N(6)-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine Analogues: Implication in the Treatment of Parkinson's Disease. Journal of Medicinal Chemistry. 58: 9179-95. PMID 26555041 DOI: 10.1021/Acs.Jmedchem.5B01031 |
0.364 |
|
| 2015 |
Stödberg T, McTague A, Ruiz AJ, Hirata H, Zhen J, Long P, Farabella I, Meyer E, Kawahara A, Vassallo G, Stivaros SM, Bjursell MK, Stranneheim H, Tigerschiöld S, Persson B, ... ... Reith ME, et al. Mutations in SLC12A5 in epilepsy of infancy with migrating focal seizures. Nature Communications. 6: 8038. PMID 26333769 DOI: 10.1038/Ncomms9038 |
0.508 |
|
| 2015 |
Zhen J, Antonio T, Ali S, Neve KA, Dutta AK, Reith ME. Use of radiolabeled antagonist assays for assessing agonism at D2 and D3 dopamine receptors: comparison with functional GTPγS assays. Journal of Neuroscience Methods. 248: 7-15. PMID 25840364 DOI: 10.1016/J.Jneumeth.2015.03.028 |
0.594 |
|
| 2015 |
Santra S, Sharma H, Vedachalam S, Antonio T, Reith M, Dutta A. Development of potent dopamine-norepinephrine uptake inhibitors (DNRIs) based on a (2S,4R,5R)-2-benzhydryl-5-((4-methoxybenzyl)amino)tetrahydro-2H-pyran-4-ol molecular template. Bioorganic & Medicinal Chemistry. 23: 821-8. PMID 25593099 DOI: 10.1016/J.Bmc.2014.12.040 |
0.43 |
|
| 2015 |
Zhen J, Antonio T, Cheng SY, Ali S, Jones KT, Reith ME. Dopamine transporter oligomerization: impact of combining protomers with differential cocaine analog binding affinities. Journal of Neurochemistry. 133: 167-73. PMID 25580950 DOI: 10.1111/Jnc.13025 |
0.674 |
|
| 2015 |
Reith ME, Blough BE, Hong WC, Jones KT, Schmitt KC, Baumann MH, Partilla JS, Rothman RB, Katz JL. Behavioral, biological, and chemical perspectives on atypical agents targeting the dopamine transporter. Drug and Alcohol Dependence. 147: 1-19. PMID 25548026 DOI: 10.1016/J.Drugalcdep.2014.12.005 |
0.451 |
|
| 2014 |
Dutta AK, Santra S, Sharma H, Voshavar C, Xu L, Mabrouk O, Antonio T, Reith ME. Pharmacological and behavioral characterization of D-473, an orally active triple reuptake inhibitor targeting dopamine, serotonin and norepinephrine transporters. Plos One. 9: e113420. PMID 25427177 DOI: 10.1371/Journal.Pone.0113420 |
0.487 |
|
| 2014 |
Ananthan S, Saini SK, Zhou G, Hobrath JV, Padmalayam I, Zhai L, Bostwick JR, Antonio T, Reith ME, McDowell S, Cho E, McAleer L, Taylor M, Luedtke RR. Design, synthesis, and structure-activity relationship studies of a series of [4-(4-carboxamidobutyl)]-1-arylpiperazines: insights into structural features contributing to dopamine D3 versus D2 receptor subtype selectivity. Journal of Medicinal Chemistry. 57: 7042-60. PMID 25126833 DOI: 10.1021/Jm500801R |
0.429 |
|
| 2014 |
Modi G, Voshavar C, Gogoi S, Shah M, Antonio T, Reith ME, Dutta AK. Multifunctional D2/D3 agonist D-520 with high in vivo efficacy: modulator of toxicity of alpha-synuclein aggregates. Acs Chemical Neuroscience. 5: 700-17. PMID 24960209 DOI: 10.1021/Cn500084X |
0.344 |
|
| 2014 |
Ng J, Zhen J, Meyer E, Erreger K, Li Y, Kakar N, Ahmad J, Thiele H, Kubisch C, Rider NL, Morton DH, Strauss KA, Puffenberger EG, D'Agnano D, Anikster Y, ... ... Reith ME, et al. Dopamine transporter deficiency syndrome: phenotypic spectrum from infancy to adulthood. Brain : a Journal of Neurology. 137: 1107-19. PMID 24613933 DOI: 10.1093/Brain/Awu022 |
0.654 |
|
| 2014 |
Modi G, Antonio T, Reith M, Dutta A. Structural modifications of neuroprotective anti-Parkinsonian (-)-N6-(2-(4-(biphenyl-4-yl)piperazin-1-yl)-ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine (D-264): an effort toward the improvement of in vivo efficacy of the parent molecule. Journal of Medicinal Chemistry. 57: 1557-72. PMID 24471976 DOI: 10.1021/Jm401883V |
0.388 |
|
| 2014 |
Sharma H, Santra S, Debnath J, Antonio T, Reith M, Dutta A. Flexible and biomimetic analogs of triple uptake inhibitor 4-((((3S,6S)-6-benzhydryltetrahydro-2H-pyran-3-yl)amino)methyl)phenol: Synthesis, biological characterization, and development of a pharmacophore model. Bioorganic & Medicinal Chemistry. 22: 311-24. PMID 24315194 DOI: 10.1016/J.Bmc.2013.11.017 |
0.468 |
|
| 2013 |
Gopishetty B, Zhang S, Kharkar PS, Antonio T, Reith M, Dutta AK. Modification of agonist binding moiety in hybrid derivative 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-1-ol/-2-amino versions: impact on functional activity and selectivity for dopamine D2/D3 receptors. Bioorganic & Medicinal Chemistry. 21: 3164-74. PMID 23623679 DOI: 10.1016/J.Bmc.2013.03.059 |
0.444 |
|
| 2013 |
Schmitt KC, Rothman RB, Reith ME. Nonclassical pharmacology of the dopamine transporter: atypical inhibitors, allosteric modulators, and partial substrates. The Journal of Pharmacology and Experimental Therapeutics. 346: 2-10. PMID 23568856 DOI: 10.1124/Jpet.111.191056 |
0.514 |
|
| 2013 |
Reith ME. Novel structure--function information on biogenic amine transporters revealed by site-directed mutagenesis and alkylation. Neurochemical Research. 38: 1301-2. PMID 23532308 DOI: 10.1007/S11064-013-1025-0 |
0.371 |
|
| 2012 |
Gogoi S, Biswas S, Modi G, Antonio T, Reith ME, Dutta AK. Novel bivalent ligands for D2/D3 dopamine receptors: Significant co-operative gain in D2 affinity and potency. Acs Medicinal Chemistry Letters. 3: 991-996. PMID 23275802 DOI: 10.1021/Ml3002117 |
0.38 |
|
| 2012 |
Santra S, Gogoi S, Gopishetty B, Antonio T, Zhen J, Reith ME, Dutta AK. Structural exploration of (3S,6S)-6-benzhydryl-N-benzyltetrahydro-2H-pyran-3-amine analogues: identification of potent triple monoamine reuptake inhibitors as potential antidepressants. Chemmedchem. 7: 2093-100. PMID 23060293 DOI: 10.1002/Cmdc.201200352 |
0.659 |
|
| 2012 |
Jones KT, Zhen J, Reith ME. Importance of cholesterol in dopamine transporter function. Journal of Neurochemistry. 123: 700-15. PMID 22957537 DOI: 10.1111/Jnc.12007 |
0.592 |
|
| 2012 |
Reith ME, Ali S, Hashim A, Sheikh IS, Theddu N, Gaddiraju NV, Mehrotra S, Schmitt KC, Murray TF, Sershen H, Unterwald EM, Davis FA. Novel C-1 substituted cocaine analogs unlike cocaine or benztropine. The Journal of Pharmacology and Experimental Therapeutics. 343: 413-25. PMID 22895898 DOI: 10.1124/Jpet.112.193771 |
0.402 |
|
| 2012 |
Johnson M, Antonio T, Reith ME, Dutta AK. Structure-activity relationship study of N⁶-(2-(4-(1H-Indol-5-yl)piperazin-1-yl)ethyl)-N⁶-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine analogues: development of highly selective D3 dopamine receptor agonists along with a highly potent D2/D3 agonist and their pharmacological characterization. Journal of Medicinal Chemistry. 55: 5826-40. PMID 22642365 DOI: 10.1021/Jm300268S |
0.389 |
|
| 2012 |
Zhen J, Ali S, Dutta AK, Reith ME. Characterization of [³H]CFT binding to the norepinephrine transporter suggests that binding of CFT and nisoxetine is not mutually exclusive. Journal of Neuroscience Methods. 203: 19-27. PMID 21933682 DOI: 10.1016/J.Jneumeth.2011.08.044 |
0.654 |
|
| 2011 |
Schmitt KC, Reith ME. The atypical stimulant and nootropic modafinil interacts with the dopamine transporter in a different manner than classical cocaine-like inhibitors. Plos One. 6: e25790. PMID 22043293 DOI: 10.1371/Journal.Pone.0025790 |
0.462 |
|
| 2011 |
Dutta AK, Gopishetty B, Gogoi S, Ali S, Zhen J, Reith M. The novel trisubstituted pyran derivative D-142 has triple monoamine reuptake inhibitory activity and exerts potent antidepressant-like activity in rodents. European Journal of Pharmacology. 671: 39-44. PMID 21963455 DOI: 10.1016/J.Ejphar.2011.09.162 |
0.626 |
|
| 2011 |
Stouffer MA, Ali S, Reith ME, Patel JC, Sarti F, Carr KD, Rice ME. SKF-83566, a D1-dopamine receptor antagonist, inhibits the dopamine transporter. Journal of Neurochemistry. 118: 714-20. PMID 21689106 DOI: 10.1111/J.1471-4159.2011.07357.X |
0.52 |
|
| 2011 |
Gopishetty B, Hazeldine S, Santra S, Johnson M, Modi G, Ali S, Zhen J, Reith M, Dutta A. Further structure-activity relationship studies on 4-((((3S,6S)-6-benzhydryltetrahydro-2H-pyran-3-yl)amino)methyl)phenol: identification of compounds with triple uptake inhibitory activity as potential antidepressant agents. Journal of Medicinal Chemistry. 54: 2924-32. PMID 21446715 DOI: 10.1021/Jm200020A |
0.657 |
|
| 2011 |
Kurian MA, Li Y, Zhen J, Meyer E, Hai N, Christen HJ, Hoffmann GF, Jardine P, von Moers A, Mordekar SR, O'Callaghan F, Wassmer E, Wraige E, Dietrich C, Lewis T, ... ... Reith ME, et al. Clinical and molecular characterisation of hereditary dopamine transporter deficiency syndrome: an observational cohort and experimental study. The Lancet. Neurology. 10: 54-62. PMID 21112253 DOI: 10.1016/S1474-4422(10)70269-6 |
0.632 |
|
| 2011 |
Kortagere S, Cheng SY, Antonio T, Zhen J, Reith ME, Dutta AK. Interaction of novel hybrid compounds with the D3 dopamine receptor: Site-directed mutagenesis and homology modeling studies. Biochemical Pharmacology. 81: 157-63. PMID 20833147 DOI: 10.1016/J.Bcp.2010.08.026 |
0.655 |
|
| 2010 |
Batman AM, Dutta AK, Reith ME, Beardsley PM. The selective dopamine uptake inhibitor, D-84, suppresses cocaine self-administration, but does not occasion cocaine-like levels of generalization. European Journal of Pharmacology. 648: 127-32. PMID 20840845 DOI: 10.1016/J.Ejphar.2010.08.051 |
0.371 |
|
| 2010 |
Nyola A, Karpowich NK, Zhen J, Marden J, Reith ME, Wang DN. Substrate and drug binding sites in LeuT. Current Opinion in Structural Biology. 20: 415-22. PMID 20739005 DOI: 10.1016/J.Sbi.2010.05.007 |
0.583 |
|
| 2010 |
Ghosh B, Antonio T, Gopishetty B, Reith M, Dutta A. Further delineation of hydrophobic binding sites in dopamine D(2)/D(3) receptors for N-4 substituents on the piperazine ring of the hybrid template 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol. Bioorganic & Medicinal Chemistry. 18: 5661-74. PMID 20605099 DOI: 10.1016/J.Bmc.2010.06.025 |
0.426 |
|
| 2010 |
Li Y, Cheng SY, Chen N, Reith ME. Interrelation of dopamine transporter oligomerization and surface presence as studied with mutant transporter proteins and amphetamine. Journal of Neurochemistry. 114: 873-85. PMID 20492355 DOI: 10.1111/J.1471-4159.2010.06818.X |
0.442 |
|
| 2010 |
Schmitt KC, Reith ME. Regulation of the dopamine transporter: aspects relevant to psychostimulant drugs of abuse. Annals of the New York Academy of Sciences. 1187: 316-40. PMID 20201860 DOI: 10.1111/J.1749-6632.2009.05148.X |
0.503 |
|
| 2010 |
Ghosh B, Antonio T, Reith ME, Dutta AK. Discovery of 4-(4-(2-((5-Hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)(propyl)amino)ethyl)piperazin-1-yl)quinolin-8-ol and its analogues as highly potent dopamine D2/D3 agonists and as iron chelator: in vivo activity indicates potential application in symptomatic and neuroprotective therapy for Parkinson's disease. Journal of Medicinal Chemistry. 53: 2114-25. PMID 20146482 DOI: 10.1021/Jm901618D |
0.433 |
|
| 2010 |
Zhen J, Antonio T, Dutta AK, Reith ME. Concentration of receptor and ligand revisited in a modified receptor binding protocol for high-affinity radioligands: [3H]Spiperone binding to D2 and D3 dopamine receptors. Journal of Neuroscience Methods. 188: 32-8. PMID 20122961 DOI: 10.1016/J.Jneumeth.2010.01.031 |
0.6 |
|
| 2010 |
Schmitt KC, Mamidyala S, Biswas S, Dutta AK, Reith ME. Bivalent phenethylamines as novel dopamine transporter inhibitors: evidence for multiple substrate-binding sites in a single transporter. Journal of Neurochemistry. 112: 1605-18. PMID 20067583 DOI: 10.1111/J.1471-4159.2010.06583.X |
0.509 |
|
| 2010 |
Ghosh B, Antonio T, Zhen J, Kharkar P, Reith ME, Dutta AK. Development of (S)-N6-(2-(4-(isoquinolin-1-yl)piperazin-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]-thiazole-2,6-diamine and its analogue as a D3 receptor preferring agonist: potent in vivo activity in Parkinson's disease animal models. Journal of Medicinal Chemistry. 53: 1023-37. PMID 20038106 DOI: 10.1021/Jm901184N |
0.604 |
|
| 2009 |
Liang YJ, Zhen J, Chen N, Reith ME. Interaction of catechol and non-catechol substrates with externally or internally facing dopamine transporters. Journal of Neurochemistry. 109: 981-94. PMID 19519772 DOI: 10.1111/J.1471-4159.2009.06034.X |
0.667 |
|
| 2009 |
Kurian MA, Zhen J, Cheng SY, Li Y, Mordekar SR, Jardine P, Morgan NV, Meyer E, Tee L, Pasha S, Wassmer E, Heales SJ, Gissen P, Reith ME, Maher ER. Homozygous loss-of-function mutations in the gene encoding the dopamine transporter are associated with infantile parkinsonism-dystonia. The Journal of Clinical Investigation. 119: 1595-603. PMID 19478460 DOI: 10.1172/Jci39060 |
0.601 |
|
| 2009 |
Kharkar PS, Batman AM, Zhen J, Beardsley PM, Reith ME, Dutta AK. Synthesis and biological characterization of (3R,4R)-4-(2-(benzhydryloxy)ethyl)-1-((R)-2-hydroxy-2-phenylethyl)-piperidin-3-ol and its stereoisomers for activity toward monoamine transporters. Chemmedchem. 4: 1075-85. PMID 19449323 DOI: 10.1002/Cmdc.200900085 |
0.683 |
|
| 2009 |
Zhou Z, Zhen J, Karpowich NK, Law CJ, Reith ME, Wang DN. Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures. Nature Structural & Molecular Biology. 16: 652-7. PMID 19430461 DOI: 10.1038/Nsmb.1602 |
0.651 |
|
| 2009 |
Brown DA, Mishra M, Zhang S, Biswas S, Parrington I, Antonio T, Reith ME, Dutta AK. Investigation of various N-heterocyclic substituted piperazine versions of 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol: effect on affinity and selectivity for dopamine D3 receptor. Bioorganic & Medicinal Chemistry. 17: 3923-33. PMID 19427222 DOI: 10.1016/J.Bmc.2009.04.031 |
0.422 |
|
| 2008 |
Brown DA, Kharkar PS, Parrington I, Reith ME, Dutta AK. Structurally constrained hybrid derivatives containing octahydrobenzo[g or f]quinoline moieties for dopamine D2 and D3 receptors: binding characterization at D2/D3 receptors and elucidation of a pharmacophore model. Journal of Medicinal Chemistry. 51: 7806-19. PMID 19053758 DOI: 10.1021/Jm8008629 |
0.416 |
|
| 2008 |
Schmitt KC, Zhen J, Kharkar P, Mishra M, Chen N, Dutta AK, Reith ME. Interaction of cocaine-, benztropine-, and GBR12909-like compounds with wild-type and mutant human dopamine transporters: molecular features that differentially determine antagonist-binding properties. Journal of Neurochemistry. 107: 928-40. PMID 18786172 DOI: 10.1111/J.1471-4159.2008.05667.X |
0.654 |
|
| 2008 |
Dutta AK, Ghosh B, Biswas S, Reith ME. D-161, a novel pyran-based triple monoamine transporter blocker: behavioral pharmacological evidence for antidepressant-like action. European Journal of Pharmacology. 589: 73-9. PMID 18561912 DOI: 10.1016/J.Ejphar.2008.05.008 |
0.47 |
|
| 2008 |
Biswas S, Hazeldine S, Ghosh B, Parrington I, Kuzhikandathil E, Reith ME, Dutta AK. Bioisosteric heterocyclic versions of 7-{[2-(4-phenyl-piperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol: identification of highly potent and selective agonists for dopamine D3 receptor with potent in vivo activity. Journal of Medicinal Chemistry. 51: 3005-19. PMID 18410082 DOI: 10.1021/Jm701524H |
0.428 |
|
| 2008 |
Mishra M, Kolhatkar R, Zhen J, Parrington I, Reith ME, Dutta AK. Further structural optimization of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine and 1,4-diazabicyclo[3.3.1]nonane derivatives by introducing an exocyclic hydroxyl group: interaction with dopamine, serotonin, and norepinephrine transporters. Bioorganic & Medicinal Chemistry. 16: 2769-78. PMID 18249549 DOI: 10.1016/J.Bmc.2008.01.009 |
0.673 |
|
| 2008 |
Chen N, Reith ME. Substrates dissociate dopamine transporter oligomers. Journal of Neurochemistry. 105: 910-20. PMID 18088380 DOI: 10.1111/J.1471-4159.2007.05195.X |
0.474 |
|
| 2008 |
Biswas S, Zhang S, Fernandez F, Ghosh B, Zhen J, Kuzhikandathil E, Reith ME, Dutta AK. Further structure-activity relationships study of hybrid 7-{[2-(4-phenylpiperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol analogues: identification of a high-affinity D3-preferring agonist with potent in vivo activity with long duration of action. Journal of Medicinal Chemistry. 51: 101-17. PMID 18072730 DOI: 10.1021/Jm070860R |
0.618 |
|
| 2008 |
Kharkar PS, Reith ME, Dutta AK. Three-dimensional quantitative structure-activity relationship (3D QSAR) and pharmacophore elucidation of tetrahydropyran derivatives as serotonin and norepinephrine transporter inhibitors. Journal of Computer-Aided Molecular Design. 22: 1-17. PMID 18060532 DOI: 10.1007/S10822-007-9146-7 |
0.359 |
|
| 2007 |
Zhou Z, Zhen J, Karpowich NK, Goetz RM, Law CJ, Reith ME, Wang DN. LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake. Science (New York, N.Y.). 317: 1390-3. PMID 17690258 DOI: 10.1126/Science.1147614 |
0.658 |
|
| 2007 |
Chen N, Reith ME. Substrates and inhibitors display different sensitivity to expression level of the dopamine transporter in heterologously expressing cells. Journal of Neurochemistry. 101: 377-88. PMID 17250655 DOI: 10.1111/J.1471-4159.2006.04384.X |
0.497 |
|
| 2006 |
Zhang S, Fernandez F, Hazeldine S, Deschamps J, Zhen J, Reith ME, Dutta AK. Further structural exploration of trisubstituted asymmetric pyran derivatives (2S,4R,5R)-2-benzhydryl-5-benzylamino-tetrahydropyran-4-ol and their corresponding disubstituted (3S,6S) pyran derivatives: a proposed pharmacophore model for high-affinity interaction with the dopamine, serotonin, and norepinephrine transporters. Journal of Medicinal Chemistry. 49: 4239-47. PMID 16821783 DOI: 10.1021/Jm0601699 |
0.681 |
|
| 2006 |
Reith ME, Zhen J, Chen N. The importance of company: Na+ and Cl- influence substrate interaction with SLC6 transporters and other proteins. Handbook of Experimental Pharmacology. 75-93. PMID 16722231 DOI: 10.1007/3-540-29784-7_4 |
0.609 |
|
| 2006 |
Zhen J, Reith ME, Carr KD. Chronic food restriction and dopamine transporter function in rat striatum. Brain Research. 1082: 98-101. PMID 16516172 DOI: 10.1016/J.Brainres.2006.01.094 |
0.608 |
|
| 2006 |
Zhang S, Zhen J, Reith ME, Dutta AK. Design, synthesis, and preliminary SAR study of 3- and 6-side-chain-extended tetrahydro-pyran analogues of cis- and trans-(6-benzhydryl-tetrahydropyran-3-yl)-benzylamine. Bioorganic & Medicinal Chemistry. 14: 3953-66. PMID 16481172 DOI: 10.1016/J.Bmc.2006.01.051 |
0.655 |
|
| 2005 |
Krunic A, Mariappan SV, Reith ME, Dunn WJ. Synthesis and monoamine transporter affinity of 3-aryl substituted trop-2-enes. Bioorganic & Medicinal Chemistry Letters. 15: 5488-93. PMID 16202585 DOI: 10.1016/j.bmcl.2005.08.082 |
0.375 |
|
| 2005 |
Zhen J, Chen N, Reith ME. Differences in interactions with the dopamine transporter as revealed by diminishment of Na(+) gradient and membrane potential: dopamine versus other substrates. Neuropharmacology. 49: 769-79. PMID 16122767 DOI: 10.1016/J.Neuropharm.2005.07.002 |
0.66 |
|
| 2005 |
Zhang S, Zhen J, Reith ME, Dutta AK. Discovery of novel trisubstituted asymmetric derivatives of (2S,4R,5R)-2-benzhydryl-5-benzylaminotetrahydropyran-4-ol, exhibiting high affinity for serotonin and norepinephrine transporters in a stereospecific manner. Journal of Medicinal Chemistry. 48: 4962-71. PMID 16033275 DOI: 10.1021/Jm049021K |
0.67 |
|
| 2005 |
Reith ME, Wang LC, Dutta AK. Pharmacological profile of radioligand binding to the norepinephrine transporter: instances of poor indication of functional activity. Journal of Neuroscience Methods. 143: 87-94. PMID 15763140 DOI: 10.1016/J.Jneumeth.2004.09.015 |
0.499 |
|
| 2005 |
Reith ME. Studying monoamine transporters: beyond hypermonoaminaemia. Journal of Neuroscience Methods. 143: 1-2. PMID 15763131 DOI: 10.1016/J.Jneumeth.2004.09.010 |
0.395 |
|
| 2004 |
Zhen J, Maiti S, Chen N, Dutta AK, Reith ME. Interaction between a hydroxypiperidine analogue of 4-(2-benzhydryloxy-ethyl)-1-(4-fluorobenzyl)piperidine and Aspartate 68 in the human dopamine transporter. European Journal of Pharmacology. 506: 17-26. PMID 15588620 DOI: 10.1016/J.Ejphar.2004.10.028 |
0.621 |
|
| 2004 |
Zhang S, Zhen J, Reith ME, Dutta AK. Structural requirements for 2,4- and 3,6-disubstituted pyran biomimetics of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine compounds to interact with monoamine transporters. Bioorganic & Medicinal Chemistry. 12: 6301-15. PMID 15519172 DOI: 10.1016/J.Bmc.2004.07.069 |
0.667 |
|
| 2004 |
Kolhatkar R, Cook CD, Ghorai SK, Deschamps J, Beardsley PM, Reith ME, Dutta AK. Further structurally constrained analogues of cis-(6-benzhydrylpiperidin-3-yl)benzylamine with elucidation of bioactive conformation: discovery of 1,4-diazabicyclo[3.3.1]nonane derivatives and evaluation of their biological properties for the monoamine transporters. Journal of Medicinal Chemistry. 47: 5101-13. PMID 15456254 DOI: 10.1021/Jm049796T |
0.509 |
|
| 2004 |
Dutta AK, Venkataraman SK, Fei XS, Kolhatkar R, Zhang S, Reith ME. Synthesis and biological characterization of novel hybrid 7-[[2-(4-phenyl-piperazin-1-yl)-ethyl]-propyl-amino]-5,6,7,8-tetrahydro-naphthalen-2-ol and their heterocyclic bioisosteric analogues for dopamine D2 and D3 receptors. Bioorganic & Medicinal Chemistry. 12: 4361-73. PMID 15265488 DOI: 10.1016/J.Bmc.2004.06.019 |
0.441 |
|
| 2004 |
Chen N, Zhen J, Reith ME. Mutation of Trp84 and Asp313 of the dopamine transporter reveals similar mode of binding interaction for GBR12909 and benztropine as opposed to cocaine. Journal of Neurochemistry. 89: 853-64. PMID 15140185 DOI: 10.1111/J.1471-4159.2004.02386.X |
0.655 |
|
| 2004 |
Chen N, Reith ME. Interaction between dopamine and its transporter: role of intracellular sodium ions and membrane potential. Journal of Neurochemistry. 89: 750-65. PMID 15086531 DOI: 10.1111/J.1471-4159.2004.02409.X |
0.443 |
|
| 2004 |
Li LB, Chen N, Ramamoorthy S, Chi L, Cui XN, Wang LC, Reith ME. The role of N-glycosylation in function and surface trafficking of the human dopamine transporter. The Journal of Biological Chemistry. 279: 21012-20. PMID 15024013 DOI: 10.1074/Jbc.M311972200 |
0.63 |
|
| 2004 |
Appell M, Berfield JL, Wang LC, Dunn WJ, Chen N, Reith ME. Structure-activity relationships for substrate recognition by the human dopamine transporter. Biochemical Pharmacology. 67: 293-302. PMID 14698042 |
0.441 |
|
| 2004 |
Chen N, Rickey J, Berfield JL, Reith ME. Aspartate 345 of the dopamine transporter is critical for conformational changes in substrate translocation and cocaine binding. The Journal of Biological Chemistry. 279: 5508-19. PMID 14660644 DOI: 10.1074/jbc.M306294200 |
0.445 |
|
| 2003 |
Wang LC, Cui XN, Chen N, Reith ME. Binding of cocaine-like radioligands to the dopamine transporter at 37 degrees C: effect of Na+ and substrates. Journal of Neuroscience Methods. 131: 27-33. PMID 14659820 DOI: 10.1016/S0165-0270(03)00230-9 |
0.416 |
|
| 2003 |
Chen N, Reith ME. Na+ and the substrate permeation pathway in dopamine transporters. European Journal of Pharmacology. 479: 213-21. PMID 14612151 DOI: 10.1016/J.EJPHAR.2003.08.070 |
0.432 |
|
| 2003 |
Dutta AK, Zhang S, Kolhatkar R, Reith ME. Dopamine transporter as target for drug development of cocaine dependence medications. European Journal of Pharmacology. 479: 93-106. PMID 14612141 |
0.412 |
|
| 2003 |
Chi L, Reith ME. Substrate-induced trafficking of the dopamine transporter in heterologously expressing cells and in rat striatal synaptosomal preparations. The Journal of Pharmacology and Experimental Therapeutics. 307: 729-36. PMID 12975490 DOI: 10.1124/Jpet.103.055095 |
0.476 |
|
| 2003 |
Chen N, Rickey J, Reith ME. Na+ stimulates binding of dopamine to the dopamine transporter in cells but not in cell-free preparations. Journal of Neurochemistry. 86: 678-86. PMID 12859681 DOI: 10.1046/j.1471-4159.2003.01889.x |
0.4 |
|
| 2003 |
Kolhatkar RB, Ghorai SK, George C, Reith ME, Dutta AK. Interaction of cis-(6-benzhydrylpiperidin-3-yl)benzylamine analogues with monoamine transporters: structure-activity relationship study of structurally constrained 3,6-disubstituted piperidine analogues of (2,2-diphenylethyl)-[1-(4-fluorobenzyl)piperidin-4-ylmethyl]amine. Journal of Medicinal Chemistry. 46: 2205-15. PMID 12747792 DOI: 10.1021/Jm020561W |
0.484 |
|
| 2003 |
Ghorai SK, Cook C, Davis M, Venkataraman SK, George C, Beardsley PM, Reith ME, Dutta AK. High affinity hydroxypiperidine analogues of 4-(2-benzhydryloxyethyl)-1-(4-fluorobenzyl)piperidine for the dopamine transporter: stereospecific interactions in vitro and in vivo. Journal of Medicinal Chemistry. 46: 1220-8. PMID 12646032 DOI: 10.1021/Jm020275K |
0.535 |
|
| 2002 |
Cao BJ, Reith ME. Nitric oxide inhibits uptake of dopamine and N-methyl-4-phenylpyridinium (MPP+) but not release of MPP+ in rat C6 glioma cells expressing human dopamine transporter. British Journal of Pharmacology. 137: 1155-62. PMID 12466224 DOI: 10.1038/sj.bjp.0704974 |
0.356 |
|
| 2002 |
Chen N, Sun L, Reith ME. Cationic interactions at the human dopamine transporter reveal binding conformations for dopamine distinguishable from those for the cocaine analog 2 alpha-carbomethoxy-3 alpha-(4-fluorophenyl)tropane. Journal of Neurochemistry. 81: 1383-93. PMID 12068085 DOI: 10.1046/j.1471-4159.2002.00941.x |
0.422 |
|
| 2002 |
Appell M, Dunn WJ, Reith ME, Miller L, Flippen-Anderson JL. An analysis of the binding of cocaine analogues to the monoamine transporters using tensor decomposition 3-d QSAR. Bioorganic & Medicinal Chemistry. 10: 1197-206. PMID 11886784 |
0.367 |
|
| 2002 |
Dutta AK, Davis MC, Fei XS, Beardsley PM, Cook CD, Reith ME. Expansion of structure-activity studies of piperidine analogues of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (GBR 12935) compounds by altering substitutions in the N-benzyl moiety and behavioral pharmacology of selected molecules. Journal of Medicinal Chemistry. 45: 654-62. PMID 11806716 DOI: 10.1021/Jm010316X |
0.494 |
|
| 2001 |
Wu Q, Reith ME, Kuhar MJ, Carroll FI, Garris PA. Preferential increases in nucleus accumbens dopamine after systemic cocaine administration are caused by unique characteristics of dopamine neurotransmission. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 6338-47. PMID 11487657 DOI: 10.1523/Jneurosci.21-16-06338.2001 |
0.343 |
|
| 2001 |
Reith ME, Berfield JL, Wang LC, Ferrer JV, Javitch JA. The uptake inhibitors cocaine and benztropine differentially alter the conformation of the human dopamine transporter. The Journal of Biological Chemistry. 276: 29012-8. PMID 11395483 DOI: 10.1074/Jbc.M011785200 |
0.371 |
|
| 2001 |
Chen N, Vaughan RA, Reith ME. The role of conserved tryptophan and acidic residues in the human dopamine transporter as characterized by site-directed mutagenesis. Journal of Neurochemistry. 77: 1116-27. PMID 11359877 DOI: 10.1046/J.1471-4159.2001.00312.X |
0.408 |
|
| 2001 |
Dutta AK, Fei XS, Beardsley PM, Newman JL, Reith ME. Structure-activity relationship studies of 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine derivatives and their N-analogues: evaluation of O-and N-analogues and their binding to monoamine transporters. Journal of Medicinal Chemistry. 44: 937-48. PMID 11300876 DOI: 10.1021/Jm000311K |
0.478 |
|
| 2000 |
Wang LC, Berfield JL, Kuhar MJ, Carroll FI, Reith ME. RTI-76, an isothiocyanate derivative of a phenyltropane cocaine analog, as a tool for irreversibly inactivating dopamine transporter function in vitro. Naunyn-Schmiedeberg's Archives of Pharmacology. 362: 238-47. PMID 10997726 DOI: 10.1007/s002100000289 |
0.407 |
|
| 2000 |
Li LB, Reith ME. Interaction of Na+, K+, and Cl- with the binding of amphetamine, octopamine, and tyramine to the human dopamine transporter. Journal of Neurochemistry. 74: 1538-52. PMID 10737611 DOI: 10.1046/J.1471-4159.2000.0741538.X |
0.639 |
|
| 1999 |
Li LB, Reith ME. Modeling of the interaction of Na+ and K+ with the binding of dopamine and [3H]WIN 35,428 to the human dopamine transporter. Journal of Neurochemistry. 72: 1095-109. PMID 10037481 DOI: 10.1046/J.1471-4159.1999.0721095.X |
0.663 |
|
| 1999 |
Berfield JL, Wang LC, Reith ME. Which form of dopamine is the substrate for the human dopamine transporter: the cationic or the uncharged species? The Journal of Biological Chemistry. 274: 4876-82. PMID 9988729 |
0.37 |
|
| 1998 |
Reith ME, Xu C, Carroll FI, Chen NH. Inhibition of [3H]dopamine translocation and [3H]cocaine analog binding: a potential screening device for cocaine antagonists. Methods in Enzymology. 296: 248-59. PMID 9779453 |
0.324 |
|
| 1998 |
Dutta AK, Xu C, Reith ME. Tolerance in the replacement of the benzhydrylic O atom in 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine derivatives by an N atom: development of new-generation potent and selective N-analogue molecules for the dopamine transporter. Journal of Medicinal Chemistry. 41: 3293-7. PMID 9703474 DOI: 10.1021/Jm980066T |
0.425 |
|
| 1997 |
Reith ME, Xu C, Chen NH. Pharmacology and regulation of the neuronal dopamine transporter. European Journal of Pharmacology. 324: 1-10. PMID 9137907 |
0.419 |
|
| 1996 |
Dutta AK, Xu C, Reith ME. Structure-activity relationship studies of novel 4-[2-[bis(4-fluorophenyl)methoxy]ethyl]-1-(3-phenylpropyl)piperidine analogs: synthesis and biological evaluation at the dopamine and serotonin transporter sites. Journal of Medicinal Chemistry. 39: 749-56. PMID 8576918 DOI: 10.1021/Jm9506581 |
0.515 |
|
| 1992 |
Reith ME, de Costa B, Rice KC, Jacobson AE. Evidence for mutually exclusive binding of cocaine, BTCP, GBR 12935, and dopamine to the dopamine transporter. European Journal of Pharmacology. 227: 417-25. PMID 1446712 DOI: 10.1016/0922-4106(92)90160-W |
0.439 |
|
| 1991 |
Debler EA, Sershen H, Hashim A, Lajtha A, Reith ME. Carrier-mediated efflux of [3H]dopamine and [3H]1-methyl-4-phenylpyridine: effect of ascorbic acid. Synapse (New York, N.Y.). 7: 99-105. PMID 2011830 DOI: 10.1002/Syn.890070203 |
0.454 |
|
| 1990 |
Reith ME, Kramer HK, Sershen H, Lajtha A. D-tartrate alters uptake of [3H]dopamine into brain synaptic vesicles. Journal of Neuroscience Methods. 31: 133-6. PMID 2319813 DOI: 10.1016/0165-0270(90)90157-B |
0.407 |
|
| 1990 |
Berger P, Elsworth JD, Reith ME, Tanen D, Roth RH. Complex interaction of cocaine with the dopamine uptake carrier. European Journal of Pharmacology. 176: 251-2. PMID 2311671 DOI: 10.1016/0014-2999(90)90540-M |
0.374 |
|
| 1989 |
Benuck M, Reith ME, Sershen H, Wiener HL, Lajtha A. Oxidative metabolism of cocaine: comparison of brain and liver. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 190: 7-13. PMID 2911610 DOI: 10.3181/00379727-190-42822 |
0.319 |
|
| 1989 |
Kramer HK, Sershen H, Lajtha A, Reith ME. The effect of nicotine on catecholaminergic storage vesicles. Brain Research. 503: 296-8. PMID 2605521 DOI: 10.1016/0006-8993(89)91677-6 |
0.382 |
|
| 1988 |
Sershen H, Berger P, Jacobson AE, Rice KC, Reith ME. Metaphit prevents locomotor activation induced by various psychostimulants and interferes with the dopaminergic system in mice. Neuropharmacology. 27: 23-30. PMID 3352864 DOI: 10.1016/0028-3908(88)90196-7 |
0.482 |
|
| 1986 |
Reith ME, Meisler BE, Sershen H, Lajtha A. Structural requirements for cocaine congeners to interact with dopamine and serotonin uptake sites in mouse brain and to induce stereotyped behavior. Biochemical Pharmacology. 35: 1123-9. PMID 3964292 DOI: 10.1016/0006-2952(86)90148-6 |
0.448 |
|
| 1986 |
Sershen H, Mason MF, Reith ME, Hashim A, Lajtha A. Effect of nicotine and amphetamine on the neurotoxicity of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mice. Neuropharmacology. 25: 1231-4. PMID 3491964 DOI: 10.1016/0028-3908(86)90140-1 |
0.446 |
|
| 1986 |
Sershen H, Mason MF, Reith ME, Hashim A, Lajtha A. Effect of amphetamine on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in mice. Neuropharmacology. 25: 927-30. PMID 3490630 DOI: 10.1016/0028-3908(86)90022-5 |
0.421 |
|
| 1985 |
Reith ME, Meisler BE, Sershen H, Lajtha A. Sodium-independent binding of [3H]cocaine in mouse striatum is serotonin related. Brain Research. 342: 145-8. PMID 4041805 DOI: 10.1016/0006-8993(85)91363-0 |
0.476 |
|
| 1985 |
Sershen H, Reith ME, Hashim A, Lajtha A. Protection against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity by the antioxidant ascorbic acid. Neuropharmacology. 24: 1257-9. PMID 3879338 DOI: 10.1016/0028-3908(85)90163-7 |
0.327 |
|
| 1984 |
Reith ME, Allen DL, Sershen H, Lajtha A. Similarities and differences between high-affinity binding sites for cocaine and imipramine in mouse cerebral cortex. Journal of Neurochemistry. 43: 249-55. PMID 6726250 |
0.302 |
|
| 1984 |
Reith ME, Meisler BE, Sershen H, Lajtha A. [3H]cocaine binding in brain is inhibited by Tris (hydroxymethyl) aminomethane. Journal of Neuroscience Methods. 12: 151-4. PMID 6527554 DOI: 10.1016/0165-0270(84)90014-1 |
0.432 |
|
| 1984 |
Sershen H, Reith ME, Hashim A, Lajtha A. Reduction of dopamine uptake and cocaine binding in mouse striatum by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. European Journal of Pharmacology. 102: 175-8. PMID 6332738 DOI: 10.1016/0014-2999(84)90354-6 |
0.497 |
|
| 1981 |
Reith ME, Sershen H, Vadasz C, Lajtha A. Strain differences in opiate receptors in mouse brain. European Journal of Pharmacology. 74: 377-80. PMID 6271560 DOI: 10.1016/0014-2999(81)90059-5 |
0.332 |
|
| 1978 |
Reith ME, Schotman P, Gispen WH. Measurements of in vivo rates of protein synthesis in brain, spinal cord, heart and liver of young versus adult rats, intact versus hypophysectomized rats. Journal of Neurochemistry. 30: 587-94. PMID 681932 DOI: 10.1111/j.1471-4159.1978.tb07812.x |
0.342 |
|
| 1977 |
Schotman P, Reith ME, Gispen WH. Effects of stressful procedures as ether anesthesia and intracranial injections on amino acid incorporation into brain protein. Brain Research Bulletin. 2: 83-7. PMID 880489 DOI: 10.1016/0361-9230(77)90002-8 |
0.367 |
|
| 1977 |
Gispen WH, Reith ME, Schotman P, Wiegant VM, Zwiers H, de Wied D. CNS and ACTH-like peptides: neurochemical response and interaction with opiates. Advances in Biochemical Psychopharmacology. 17: 61-80. PMID 200081 |
0.49 |
|
| 1975 |
Reith ME, Schotman P, Gispen WH. The neurotropic action of ACTH: effects of ACTH-like peptides on the incorporation of leucine into protein of brain stem slices from hypophysectomized rats. Neuroscience Letters. 1: 55-9. PMID 19604752 DOI: 10.1016/0304-3940(75)90012-9 |
0.355 |
|
| 1975 |
Reith ME, Schotman P, Gispen WH. Effects of behaviorally active ACTH analogs on brain protein metabolism. Progress in Brain Research. 42: 195-200. PMID 172963 DOI: 10.1016/S0079-6123(08)63660-2 |
0.357 |
|
| 1974 |
Reith ME, Schotman P, Gispen WH. Hypophysectomy, ACTH1-10 and in vitro protein synthesis in rat brain stem slices. Brain Research. 81: 571-5. PMID 4373137 DOI: 10.1016/0006-8993(74)90855-5 |
0.358 |
|
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