| Year |
Citation |
Score |
| 2024 |
Larson EC, Ellis-Connell AL, Rodgers MA, Gubernat AK, Gleim JL, Moriarty RV, Balgeman AJ, Ameel CL, Jauro S, Tomko JA, Kracinovsky KB, Maiello P, Borish HJ, White AG, Klein E, ... ... Flynn JL, et al. Author Correction: Intravenous Bacille Calmette-Guérin vaccination protects simian immunodeficiency virus-infected macaques from tuberculosis. Nature Microbiology. PMID 38355766 DOI: 10.1038/s41564-024-01631-y |
0.676 |
|
| 2023 |
Ganchua SK, Maiello P, Chao M, Hopkins F, Mugahid D, Lin PL, Fortune SM, Flynn JL. Antibiotic treatment does not abrogate protection against Mycobacterium tuberculosis reinfection in Macaques. Biorxiv : the Preprint Server For Biology. PMID 38187678 DOI: 10.1101/2023.12.19.570845 |
0.421 |
|
| 2023 |
Bromley JD, Ganchua SKC, Nyquist SK, Maiello P, Chao M, Borish HJ, Rodgers M, Tomko J, Kracinovsky K, Mugahid D, Nguyen S, Wang D, Rosenberg JM, Klein EC, Gideon HP, ... ... Flynn JL, et al. CD4 T cells are homeostatic regulators during reinfection. Biorxiv : the Preprint Server For Biology. PMID 38187598 DOI: 10.1101/2023.12.20.572669 |
0.707 |
|
| 2023 |
Smith AA, Su H, Wallach J, Liu Y, Maiello P, Borish HJ, Winchell C, Simonson AW, Lin PL, Rodgers M, Fillmore D, Sakal J, Lin K, Schnappinger D, Ehrt S, ... Flynn JL, et al. A "suicide" BCG strain provides enhanced immunogenicity and robust protection against in macaques. Biorxiv : the Preprint Server For Biology. PMID 38045242 DOI: 10.1101/2023.11.22.568105 |
0.304 |
|
| 2023 |
Looney MM, Hatherill M, Musvosvi M, Flynn J, Kagina BM, Frick M, Kafuko Z, Schmidt A, Southern J, Wilder-Smith A, Tippoo P, Paradkar V, Popadić D, Scriba TJ, Hanekom W, et al. Conference report: WHO meeting report on mRNA-based tuberculosis vaccine development. Vaccine. PMID 37872013 DOI: 10.1016/j.vaccine.2023.10.026 |
0.304 |
|
| 2023 |
Winchell CG, Nyquist SK, Chao MC, Maiello P, Myers AJ, Hopkins F, Chase M, Gideon HP, Patel KV, Bromley JD, Simonson AW, Floyd-O'Sullivan R, Wadsworth M, Rosenberg JM, Uddin R, ... ... Flynn JL, et al. CD8+ lymphocytes are critical for early control of tuberculosis in macaques. The Journal of Experimental Medicine. 220. PMID 37843832 DOI: 10.1084/jem.20230707 |
0.707 |
|
| 2023 |
Larson EC, Ellis-Connell AL, Rodgers MA, Gubernat AK, Gleim JL, Moriarty RV, Balgeman AJ, Ameel CL, Jauro S, Tomko JA, Kracinovsky KB, Maiello P, Borish HJ, White AG, Klein E, ... ... Flynn JL, et al. Intravenous Bacille Calmette-Guérin vaccination protects simian immunodeficiency virus-infected macaques from tuberculosis. Nature Microbiology. PMID 37814073 DOI: 10.1038/s41564-023-01503-x |
0.715 |
|
| 2023 |
Peters JM, Irvine EB, Rosenberg JM, Wadsworth MH, Hughes TK, Sutton M, Nyquist SK, Bromley JD, Mondal R, Roederer M, Seder RA, Darrah PA, Alter G, Flynn JL, Shalek AK, et al. Protective intravenous BCG vaccination induces enhanced immune signaling in the airways. Biorxiv : the Preprint Server For Biology. PMID 37502895 DOI: 10.1101/2023.07.16.549208 |
0.304 |
|
| 2023 |
Esmail H, Coussens AK, Thienemann F, Sossen B, Mukasa SL, Warwick J, Goliath RT, Davies NO, Douglass E, Jackson A, Lakay F, Streicher E, Munro JE, Barrios MH, Heinsohn T, ... ... Flynn JL, et al. High resolution imaging and five-year tuberculosis contact outcomes. Medrxiv : the Preprint Server For Health Sciences. PMID 37461515 DOI: 10.1101/2023.07.03.23292111 |
0.322 |
|
| 2023 |
Liu YE, Darrah PA, Zeppa JJ, Kamath M, Laboune F, Douek DC, Maiello P, Roederer M, Flynn JL, Seder RA, Khatri P. Blood transcriptional correlates of BCG-induced protection against tuberculosis in rhesus macaques. Cell Reports. Medicine. 101096. PMID 37390827 DOI: 10.1016/j.xcrm.2023.101096 |
0.33 |
|
| 2023 |
Khan RMN, Ahn YM, Marriner GA, Via LE, D'Hooge F, Lee SS, Yang N, Basuli F, White AG, Tomko JA, Frye LJ, Scanga CA, Weiner DM, Sutphen ML, Schimel DM, ... ... Flynn JL, et al. Distributable, Metabolic PET Reporting of Tuberculosis. Biorxiv : the Preprint Server For Biology. PMID 37333343 DOI: 10.1101/2023.04.03.535218 |
0.611 |
|
| 2023 |
Budak M, Cicchese JM, Maiello P, Borish HJ, White AG, Chishti HB, Tomko J, Frye LJ, Fillmore D, Kracinovsky K, Sakal J, Scanga CA, Lin PL, Dartois V, Linderman JJ, ... Flynn JL, et al. Optimizing tuberculosis treatment efficacy: Comparing the standard regimen with Moxifloxacin-containing regimens. Plos Computational Biology. 19: e1010823. PMID 37319311 DOI: 10.1371/journal.pcbi.1010823 |
0.647 |
|
| 2023 |
Darrah PA, Zeppa JJ, Wang C, Irvine EB, Bucsan AN, Rodgers MA, Pokkali S, Hackney JA, Kamath M, White AG, Borish HJ, Frye LJ, Tomko J, Kracinovsky K, Lin PL, ... ... Flynn JL, et al. Airway T cells are a correlate of i.v. Bacille Calmette-Guerin-mediated protection against tuberculosis in rhesus macaques. Cell Host & Microbe. PMID 37267955 DOI: 10.1016/j.chom.2023.05.006 |
0.7 |
|
| 2023 |
Larson E, Ellis-Connell A, Rodgers M, Gubernat A, Gleim J, Moriarty R, Balgeman A, Ameel C, Jauro S, Tomko J, Kracinovsky K, Maiello P, Borish H, White A, Klein E, ... ... Flynn J, et al. Vaccination with intravenous BCG protects macaques with pre-existing SIV infection from tuberculosis. Research Square. PMID 37090620 DOI: 10.21203/rs.3.rs-2802306/v1 |
0.721 |
|
| 2023 |
Grant NL, Kelly K, Maiello P, Abbott H, O'Connor S, Lin PL, Scanga CA, Flynn JL. Mycobacterium tuberculosis-Specific CD4 T Cells Expressing Transcription Factors T-Bet or RORγT Associate with Bacterial Control in Granulomas. Mbio. e0047723. PMID 37039646 DOI: 10.1128/mbio.00477-23 |
0.753 |
|
| 2023 |
Medrano JM, Maiello P, Rutledge T, Tomko J, Rodgers MA, Fillmore D, Frye LJ, Janssen C, Klein E, Flynn JL, Lin PL. Characterizing the Spectrum of Latent Mycobacterium tuberculosis in the Cynomolgus Macaque Model: Clinical, Immunologic, and Imaging Features of Evolution. The Journal of Infectious Diseases. 227: 592-601. PMID 36611221 DOI: 10.1093/infdis/jiac504 |
0.43 |
|
| 2022 |
Flynn JL, Chan J. Immune cell interactions in tuberculosis. Cell. 185: 4682-4702. PMID 36493751 DOI: 10.1016/j.cell.2022.10.025 |
0.365 |
|
| 2022 |
Joslyn LR, Flynn JL, Kirschner DE, Linderman JJ. Concomitant immunity to M. tuberculosis infection. Scientific Reports. 12: 20731. PMID 36456599 DOI: 10.1038/s41598-022-24516-8 |
0.428 |
|
| 2022 |
Yoon SH, Goo JM, Yim JJ, Yoshiyama T, Flynn JL. CT and F-FDG PET abnormalities in contacts with recent tuberculosis infections but negative chest X-ray. Insights Into Imaging. 13: 112. PMID 35796839 DOI: 10.1186/s13244-022-01255-y |
0.41 |
|
| 2022 |
Grant NL, Maiello P, Klein E, Lin PL, Borish HJ, Tomko J, Frye LJ, White AG, Kirschner DE, Mattila JT, Flynn JL. T cell transcription factor expression evolves over time in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques. Cell Reports. 39: 110826. PMID 35584684 DOI: 10.1016/j.celrep.2022.110826 |
0.429 |
|
| 2022 |
Gideon HP, Hughes TK, Tzouanas CN, Wadsworth MH, Tu AA, Gierahn TM, Peters JM, Hopkins FF, Wei JR, Kummerlowe C, Grant NL, Nargan K, Phuah JY, Borish HJ, Maiello P, ... ... Flynn JL, et al. Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control. Immunity. PMID 35483355 DOI: 10.1016/j.immuni.2022.04.004 |
0.699 |
|
| 2021 |
Stammes MA, Lee JH, Meijer L, Naninck T, Doyle-Meyers LA, White AG, Borish HJ, Hartman AL, Alvarez X, Ganatra S, Kaushal D, Bohm RP, le Grand R, Scanga CA, Langermans JAM, ... ... Flynn JL, et al. Medical imaging of pulmonary disease in SARS-CoV-2-exposed non-human primates. Trends in Molecular Medicine. PMID 34955425 DOI: 10.1016/j.molmed.2021.12.001 |
0.598 |
|
| 2021 |
Irvine EB, O'Neil A, Darrah PA, Shin S, Choudhary A, Li W, Honnen W, Mehra S, Kaushal D, Gideon HP, Flynn JL, Roederer M, Seder RA, Pinter A, Fortune S, et al. Robust IgM responses following intravenous vaccination with Bacille Calmette-Guérin associate with prevention of Mycobacterium tuberculosis infection in macaques. Nature Immunology. 22: 1515-1523. PMID 34811542 DOI: 10.1038/s41590-021-01066-1 |
0.337 |
|
| 2021 |
Mattila JT, Beaino W, White AG, Nyiranshuti L, Maiello P, Tomko J, Frye LJ, Fillmore D, Scanga CA, Lin PL, Flynn JL, Anderson CJ. Retention of Cu-FLFLF, a Formyl Peptide Receptor 1-Specific PET Probe, Correlates with Macrophage and Neutrophil Abundance in Lung Granulomas from Cynomolgus Macaques. Acs Infectious Diseases. PMID 34255474 DOI: 10.1021/acsinfecdis.0c00826 |
0.658 |
|
| 2021 |
Sher A, Flynn JL. Sterilizing immunity: New opportunities for rational TB vaccine design. The Journal of Experimental Medicine. 218. PMID 34037668 DOI: 10.1084/jem.20210454 |
0.301 |
|
| 2020 |
Millar JA, Butler JR, Evans S, Mattila JT, Linderman JJ, Flynn JL, Kirschner DE. Spatial Organization and Recruitment of Non-Specific T Cells May Limit T Cell-Macrophage Interactions Within Granulomas. Frontiers in Immunology. 11: 613638. PMID 33552077 DOI: 10.3389/fimmu.2020.613638 |
0.442 |
|
| 2020 |
Hartman AL, Nambulli S, McMillen CM, White AG, Tilston-Lunel NL, Albe JR, Cottle E, Dunn MD, Frye LJ, Gilliland TH, Olsen EL, O'Malley KJ, Schwarz MM, Tomko JA, Walker RC, ... ... Flynn JL, et al. SARS-CoV-2 infection of African green monkeys results in mild respiratory disease discernible by PET/CT imaging and shedding of infectious virus from both respiratory and gastrointestinal tracts. Plos Pathogens. 16: e1008903. PMID 32946524 DOI: 10.1371/Journal.Ppat.1008903 |
0.665 |
|
| 2020 |
Diedrich CR, Rutledge T, Maiello P, Baranowski TM, White AG, Borish HJ, Karell P, Hopkins F, Brown J, Fortune SM, Flynn JL, Ambrose Z, Lin PL. SIV and Mycobacterium tuberculosis synergy within the granuloma accelerates the reactivation pattern of latent tuberculosis. Plos Pathogens. 16: e1008413. PMID 32730321 DOI: 10.1371/Journal.Ppat.1008413 |
0.833 |
|
| 2020 |
Kim S, Scanga CA, Miranda Silva C, Zimmerman M, Causgrove C, Stein B, Dartois V, Peloquin CA, Graham E, Louie A, Flynn JL, Schmidt S, Drusano GL. Pharmacokinetics of tedizolid, sutezolid, and sutezolid-M1 in non-human primates. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 105421. PMID 32531349 DOI: 10.1016/J.Ejps.2020.105421 |
0.671 |
|
| 2020 |
Winchell CG, Mishra BB, Phuah JY, Saqib M, Nelson SJ, Maiello P, Causgrove CM, Ameel CL, Stein B, Borish HJ, White AG, Klein EC, Zimmerman MD, Dartois V, Lin PL, ... ... Flynn JL, et al. Evaluation of IL-1 Blockade as an Adjunct to Linezolid Therapy for Tuberculosis in Mice and Macaques. Frontiers in Immunology. 11: 891. PMID 32477361 DOI: 10.3389/Fimmu.2020.00891 |
0.417 |
|
| 2020 |
Wessler T, Joslyn LR, Borish HJ, Gideon HP, Flynn JL, Kirschner DE, Linderman JJ. A computational model tracks whole-lung Mycobacterium tuberculosis infection and predicts factors that inhibit dissemination. Plos Computational Biology. 16: e1007280. PMID 32433646 DOI: 10.1371/Journal.Pcbi.1007280 |
0.528 |
|
| 2020 |
Ziegler CGK, Allon SJ, Nyquist SK, Mbano IM, Miao VN, Tzouanas CN, Cao Y, Yousif AS, Bals J, Hauser BM, Feldman J, Muus C, Wadsworth MH, Kazer SW, Hughes TK, ... ... Flynn JL, et al. SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues. Cell. PMID 32413319 DOI: 10.1016/J.Cell.2020.04.035 |
0.361 |
|
| 2020 |
Darrah PA, Zeppa JJ, Maiello P, Hackney JA, Wadsworth MH, Hughes TK, Pokkali S, Swanson PA, Grant NL, Rodgers MA, Kamath M, Causgrove CM, Laddy DJ, Bonavia A, Casimiro D, ... ... Flynn JL, et al. Prevention of tuberculosis in macaques after intravenous BCG immunization. Nature. 577: 95-102. PMID 31894150 DOI: 10.1038/S41586-019-1817-8 |
0.748 |
|
| 2019 |
Wong EA, Evans S, Kraus CR, Engelman KD, Maiello P, Flores WJ, Cadena AM, Klein E, Thomas K, White AG, Causgrove C, Stein B, Tomko J, Mattila JT, Gideon H, ... ... Flynn JL, et al. IL-10 Impairs Local Immune Response in Lung Granulomas and Lymph Nodes during Early Infection. Journal of Immunology (Baltimore, Md. : 1950). PMID 31862711 DOI: 10.4049/Jimmunol.1901211 |
0.41 |
|
| 2019 |
Darrah PA, DiFazio RM, Maiello P, Gideon HP, Myers AJ, Rodgers MA, Hackney JA, Lindenstrom T, Evans T, Scanga CA, Prikhodko V, Andersen P, Lin PL, Laddy D, Roederer M, ... ... Flynn JL, et al. Boosting BCG with proteins or rAd5 does not enhance protection against tuberculosis in rhesus macaques. Npj Vaccines. 4: 21. PMID 31149352 DOI: 10.1038/s41541-019-0113-9 |
0.726 |
|
| 2018 |
Ganchua SKC, Cadena AM, Maiello P, Gideon HP, Myers AJ, Junecko BF, Klein EC, Lin PL, Mattila JT, Flynn JL. Lymph nodes are sites of prolonged bacterial persistence during Mycobacterium tuberculosis infection in macaques. Plos Pathogens. 14: e1007337. PMID 30383808 DOI: 10.1371/journal.ppat.1007337 |
0.406 |
|
| 2018 |
Lin PL, Flynn JL. The End of the Binary Era: Revisiting the Spectrum of Tuberculosis. Journal of Immunology (Baltimore, Md. : 1950). 201: 2541-2548. PMID 30348659 DOI: 10.4049/jimmunol.1800993 |
0.418 |
|
| 2018 |
Cadena AM, Hopkins FF, Maiello P, Carey AF, Wong EA, Martin CJ, Gideon HP, DiFazio RM, Andersen P, Lin PL, Fortune SM, Flynn JL. Concurrent infection with Mycobacterium tuberculosis confers robust protection against secondary infection in macaques. Plos Pathogens. 14: e1007305. PMID 30312351 DOI: 10.1371/Journal.Ppat.1007305 |
0.428 |
|
| 2018 |
Cadena AM, Ma Y, Ding T, Bryant M, Maiello P, Geber A, Lin PL, Flynn JL, Ghedin E. Profiling the airway in the macaque model of tuberculosis reveals variable microbial dysbiosis and alteration of community structure. Microbiome. 6: 180. PMID 30301469 DOI: 10.1186/s40168-018-0560-y |
0.399 |
|
| 2018 |
Joslyn LR, Pienaar E, DiFazio RM, Suliman S, Kagina BM, Flynn JL, Scriba TJ, Linderman JJ, Kirschner DE. Integrating Non-human Primate, Human, and Mathematical Studies to Determine the Influence of BCG Timing on H56 Vaccine Outcomes. Frontiers in Microbiology. 9: 1734. PMID 30177914 DOI: 10.3389/Fmicb.2018.01734 |
0.37 |
|
| 2018 |
Mellors TR, Nasir M, Franchina FA, Smolinska A, Blanchet L, Flynn J, Tomko JA, O'Malley MJ, Scanga CA, Lin PL, Wagner J, Hill JE. Identification of Mycobacterium tuberculosis using volatile biomarkers in culture and exhaled breath. Journal of Breath Research. PMID 29910196 DOI: 10.1088/1752-7163/Aacd18 |
0.725 |
|
| 2018 |
Wong EA, Joslyn L, Grant NL, Klein E, Lin PL, Kirschner DE, Flynn JL. Low levels of T cell exhaustion in tuberculous lung granulomas. Infection and Immunity. PMID 29891540 DOI: 10.1128/Iai.00426-18 |
0.479 |
|
| 2018 |
Thompson EG, Shankar S, Gideon HP, Braun J, Valvo J, Skinner J, Aderem A, Flynn JL, Lin PL, Zak DE. Blood RNA signatures prospectively discriminate controllers from progressors early after low-dose M. tuberculosis infection of cynomolgus macaques. The Journal of Infectious Diseases. PMID 29325117 DOI: 10.1093/Infdis/Jiy006 |
0.397 |
|
| 2018 |
Gregg RW, Maiello P, Borish HJ, Coleman MT, Reed DS, White AG, Flynn JL, Lin PL. Spatial and temporal evolution of lung granulomas in a cynomolgus macaque model of Mycobacterium tuberculosis infection Radiology of Infectious Diseases. 5: 110-117. DOI: 10.1016/J.JRID.2018.08.001 |
0.339 |
|
| 2017 |
Maiello P, DiFazio RM, Cadena AM, Rodgers MA, Lin PL, Scanga CA, Flynn JL. Rhesus macaques are more susceptible to progressive tuberculosis than cynomolgus macaques: A quantitative comparison. Infection and Immunity. PMID 28947646 DOI: 10.1128/Iai.00505-17 |
0.736 |
|
| 2017 |
White AG, Maiello P, Coleman MT, Tomko JA, Frye LJ, Scanga CA, Lin PL, Flynn JL. Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates. Journal of Visualized Experiments : Jove. PMID 28930979 DOI: 10.3791/56375 |
0.698 |
|
| 2017 |
Cadena AM, Fortune SM, Flynn JL. Heterogeneity in tuberculosis. Nature Reviews. Immunology. PMID 28736436 DOI: 10.1038/Nri.2017.69 |
0.523 |
|
| 2017 |
Warsinske HC, DiFazio RM, Linderman JJ, Flynn JL, Kirschner DE. Identifying mechanisms driving formation of granuloma-associated fibrosis during Mycobacterium tuberculosis infection. Journal of Theoretical Biology. PMID 28642013 DOI: 10.1016/J.Jtbi.2017.06.017 |
0.395 |
|
| 2017 |
Mattila JT, Beaino W, Maiello P, Coleman MT, White AG, Scanga CA, Flynn JL, Anderson CJ. Positron Emission Tomography Imaging of Macaques with Tuberculosis Identifies Temporal Changes in Granuloma Glucose Metabolism and Integrin α4β1-Expressing Immune Cells. Journal of Immunology (Baltimore, Md. : 1950). PMID 28592427 DOI: 10.4049/Jimmunol.1700231 |
0.686 |
|
| 2017 |
Rockwood N, Costa DL, Amaral EP, Du Bruyn E, Kubler A, Gil-Santana L, Fukutani KF, Scanga CA, Flynn JL, Jackson SH, Wilkinson KA, Bishai WR, Sher A, Wilkinson RJ, Andrade BB. Mycobacterium tuberculosis Induction of Heme Oxygenase-1 Expression Is Dependent on Oxidative Stress and Reflects Treatment Outcomes. Frontiers in Immunology. 8: 542. PMID 28553288 DOI: 10.3389/Fimmu.2017.00542 |
0.68 |
|
| 2017 |
Martin CJ, Cadena AM, Leung VW, Lin PL, Maiello P, Hicks N, Chase MR, Flynn JL, Fortune SM. Digitally Barcoding Mycobacterium tuberculosis Reveals In Vivo Infection Dynamics in the Macaque Model of Tuberculosis. Mbio. 8. PMID 28487426 DOI: 10.1128/Mbio.00312-17 |
0.535 |
|
| 2017 |
Wonderlich ER, Swan ZD, Bissel SJ, Hartman AL, Carney JP, O'Malley KJ, Obadan AO, Santos J, Walker R, Sturgeon TJ, Frye LJ, Maiello P, Scanga CA, Bowling JD, Bouwer AL, ... ... Flynn JL, et al. Widespread Virus Replication in Alveoli Drives Acute Respiratory Distress Syndrome in Aerosolized H5N1 Influenza Infection of Macaques. Journal of Immunology (Baltimore, Md. : 1950). PMID 28062701 DOI: 10.4049/Jimmunol.1601770 |
0.64 |
|
| 2017 |
Mellors TR, Blanchet L, Flynn JL, Tomko J, O'Malley M, Scanga CA, Lin PL, Hill JE. A new method to evaluate macaque health using exhaled breath: A case study of M. tuberculosis in a BSL-3 setting. Journal of Applied Physiology (Bethesda, Md. : 1985). jap.00888.2016. PMID 28057819 DOI: 10.1152/Japplphysiol.00888.2016 |
0.707 |
|
| 2016 |
Gideon HP, Skinner JA, Baldwin N, Flynn JL, Lin PL. Early Whole Blood Transcriptional Signatures Are Associated with Severity of Lung Inflammation in Cynomolgus Macaques with Mycobacterium tuberculosis Infection. Journal of Immunology (Baltimore, Md. : 1950). PMID 27837110 DOI: 10.4049/Jimmunol.1601138 |
0.427 |
|
| 2016 |
Cadena AM, Klein EC, White AG, Tomko JA, Chedrick CL, Reed DS, Via LE, Lin PL, Flynn JL. Very Low Doses of Mycobacterium tuberculosis Yield Diverse Host Outcomes in Common Marmosets (Callithrix jacchus). Comparative Medicine. 66: 412-419. PMID 27780009 |
0.347 |
|
| 2016 |
Esmail H, Lai RP, Lesosky M, Wilkinson KA, Graham CM, Coussens AK, Oni T, Warwick JM, Said-Hartley Q, Koegelenberg CF, Walzl G, Flynn JL, Young DB, Barry Iii CE, O'Garra A, et al. Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[(18)F]fluoro-D-glucose positron emission and computed tomography. Nature Medicine. PMID 27595321 DOI: 10.1038/Nm.4161 |
0.411 |
|
| 2016 |
Silver RF, Myers AJ, Jarvela J, Flynn J, Rutledge T, Bonfield T, Lin PL. Diversity of Human and Macaque Airway Immune Cells at Baseline and During Tuberculosis Infection. American Journal of Respiratory Cell and Molecular Biology. PMID 27509488 DOI: 10.1165/Rcmb.2016-0122Oc |
0.546 |
|
| 2016 |
Lin PL, Maiello P, Gideon HP, Coleman MT, Cadena AM, Rodgers MA, Gregg R, O'Malley M, Tomko J, Fillmore D, Frye LJ, Rutledge T, DiFazio RM, Janssen C, Klein E, ... ... Flynn JL, et al. PET CT Identifies Reactivation Risk in Cynomolgus Macaques with Latent M. tuberculosis. Plos Pathogens. 12: e1005739. PMID 27379816 DOI: 10.1371/Journal.Ppat.1005739 |
0.473 |
|
| 2016 |
DiFazio RM, Mattila JT, Klein EC, Cirrincione LR, Howard M, Wong EA, Flynn JL. Active transforming growth factor-β is associated with phenotypic changes in granulomas after drug treatment in pulmonary tuberculosis. Fibrogenesis & Tissue Repair. 9: 6. PMID 27148404 DOI: 10.1186/S13069-016-0043-3 |
0.407 |
|
| 2016 |
Marino S, Gideon HP, Gong C, Mankad S, McCrone JT, Lin PL, Linderman JJ, Flynn JL, Kirschner DE. Computational and Empirical Studies Predict Mycobacterium tuberculosis-Specific T Cells as a Biomarker for Infection Outcome. Plos Computational Biology. 12: e1004804. PMID 27065304 DOI: 10.1371/Journal.Pcbi.1004804 |
0.415 |
|
| 2016 |
Cadena AM, Flynn JL, Fortune SM. The Importance of First Impressions: Early Events in Mycobacterium tuberculosis Infection Influence Outcome. Mbio. 7. PMID 27048801 DOI: 10.1128/Mbio.00342-16 |
0.515 |
|
| 2016 |
Banada PP, Naidoo U, Deshpande S, Karim F, Flynn JL, O'Malley M, Jones M, Nanassy O, Jeena P, Alland D. A Novel Sample Processing Method for Rapid Detection of Tuberculosis in the Stool of Pediatric Patients Using the Xpert MTB/RIF Assay. Plos One. 11: e0151980. PMID 27007974 DOI: 10.1371/Journal.Pone.0151980 |
0.378 |
|
| 2016 |
Phuah J, Wong EA, Gideon HP, Maiello P, Coleman MT, Hendricks MR, Ruden R, Cirrincione LR, Chan J, Lin PL, Flynn JL. The Effects of B cell Depletion on early Mycobacterium tuberculosis infection in Cynomolgus Macaques. Infection and Immunity. PMID 26883591 DOI: 10.1128/IAI.00083-16 |
0.445 |
|
| 2015 |
Mothé BR, Lindestam Arlehamn CS, Dow C, Dillon MB, Wiseman RW, Bohn P, Karl J, Golden NA, Gilpin T, Foreman TW, Rodgers MA, Mehra S, Scriba TJ, Flynn JL, Kaushal D, et al. The TB-specific CD4(+) T cell immune repertoire in both cynomolgus and rhesus macaques largely overlap with humans. Tuberculosis (Edinburgh, Scotland). PMID 26526557 DOI: 10.1016/J.Tube.2015.07.005 |
0.493 |
|
| 2015 |
Via LE, England K, Weiner DM, Schimel D, Zimmerman MD, Dayao E, Chen RY, Dodd LE, Richardson M, Robbins KK, Cai Y, Hammoud D, Herscovitch P, Dartois V, Flynn JL, et al. A Sterilizing Tuberculosis Treatment Regimen Is Associated with Faster Clearance of Bacteria in Cavitary Lesions in Marmosets. Antimicrobial Agents and Chemotherapy. 59: 4181-9. PMID 25941223 DOI: 10.1128/Aac.00115-15 |
0.374 |
|
| 2015 |
Lin PL, Flynn JL. CD8 T cells and Mycobacterium tuberculosis infection. Seminars in Immunopathology. 37: 239-49. PMID 25917388 DOI: 10.1007/S00281-015-0490-8 |
0.571 |
|
| 2015 |
Flynn JL, Gideon HP, Mattila JT, Lin PL. Immunology studies in non-human primate models of tuberculosis. Immunological Reviews. 264: 60-73. PMID 25703552 DOI: 10.1111/Imr.12258 |
0.505 |
|
| 2015 |
Wolf TM, Mugisha L, Shoyama FM, O'Malley MJ, Flynn JL, Asiimwe B, Travis DA, Singer RS, Sreevatsan S. Noninvasive test for tuberculosis detection among primates. Emerging Infectious Diseases. 21: 468-70. PMID 25695329 DOI: 10.3201/Eid2103.140052 |
0.432 |
|
| 2015 |
Mattila JT, Maiello P, Sun T, Via LE, Flynn JL. Granzyme B-expressing neutrophils correlate with bacterial load in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques. Cellular Microbiology. PMID 25653138 DOI: 10.1111/Cmi.12428 |
0.498 |
|
| 2015 |
Gideon HP, Phuah J, Myers AJ, Bryson BD, Rodgers MA, Coleman MT, Maiello P, Rutledge T, Marino S, Fortune SM, Kirschner DE, Lin PL, Flynn JL. Variability in tuberculosis granuloma T cell responses exists, but a balance of pro- and anti-inflammatory cytokines is associated with sterilization. Plos Pathogens. 11: e1004603. PMID 25611466 DOI: 10.1371/Journal.Ppat.1004603 |
0.372 |
|
| 2015 |
Pienaar E, Cilfone NA, Lin PL, Dartois V, Mattila JT, Butler JR, Flynn JL, Kirschner DE, Linderman JJ. A computational tool integrating host immunity with antibiotic dynamics to study tuberculosis treatment. Journal of Theoretical Biology. 367: 166-79. PMID 25497475 DOI: 10.1016/J.Jtbi.2014.11.021 |
0.349 |
|
| 2015 |
Marino S, Cilfone NA, Mattila JT, Linderman JJ, Flynn JL, Kirschner DE. Macrophage polarization drives granuloma outcome during Mycobacterium tuberculosis infection. Infection and Immunity. 83: 324-38. PMID 25368116 DOI: 10.1128/Iai.02494-14 |
0.455 |
|
| 2015 |
Behr M, Ellis R, Ernst J, Evans T, Flynn J, Hatherill M, Hoft D, Lalvani A, McShane H, Nardell E, Ordway D, Ramanathan R, Ruhwald M, Schlesinger L, Self S, et al. Developing vaccines to prevent sustained infection with Mycobacterium tuberculosis: Conference proceedings. National Institute of Allergy and Infectious Diseases, Rockville, Maryland USA, November 7, 2014. Vaccine. 33: 3056-3064. DOI: 10.1016/J.Vaccine.2015.03.061 |
0.453 |
|
| 2014 |
Coleman MT, Chen RY, Lee M, Lin PL, Dodd LE, Maiello P, Via LE, Kim Y, Marriner G, Dartois V, Scanga C, Janssen C, Wang J, Klein E, Cho SN, ... ... Flynn JL, et al. PET/CT imaging reveals a therapeutic response to oxazolidinones in macaques and humans with tuberculosis. Science Translational Medicine. 6: 265ra167. PMID 25473035 DOI: 10.1126/Scitranslmed.3009500 |
0.689 |
|
| 2014 |
Chan J, Mehta S, Bharrhan S, Chen Y, Achkar JM, Casadevall A, Flynn J. The role of B cells and humoral immunity in Mycobacterium tuberculosis infection. Seminars in Immunology. 26: 588-600. PMID 25458990 DOI: 10.1016/j.smim.2014.10.005 |
0.327 |
|
| 2014 |
Scanga CA, Flynn JL. Modeling tuberculosis in nonhuman primates. Cold Spring Harbor Perspectives in Medicine. 4: a018564. PMID 25213189 DOI: 10.1101/Cshperspect.A018564 |
0.737 |
|
| 2014 |
Kling HM, Nau GJ, Ross TM, Evans TG, Chakraborty K, Empey KM, Flynn JL. Challenges and future in vaccines, drug development, and immunomodulatory therapy. Annals of the American Thoracic Society. 11: S201-10. PMID 25148426 DOI: 10.1513/Annalsats.201401-036Pl |
0.365 |
|
| 2014 |
Scanga CA, Lopresti BJ, Tomko J, Frye LJ, Coleman TM, Fillmore D, Carney JP, Lin PL, Flynn JL, Gardner CL, Sun C, Klimstra WB, Ryman KD, Reed DS, Fisher DJ, et al. In vivo imaging in an ABSL-3 regional biocontainment laboratory. Pathogens and Disease. 71: 207-12. PMID 24838691 DOI: 10.1111/2049-632X.12186 |
0.628 |
|
| 2014 |
Ravindran R, Krishnan VV, Dhawan R, Wunderlich ML, Lerche NW, Flynn JL, Luciw PA, Khan IH. Plasma antibody profiles in non-human primate tuberculosis. Journal of Medical Primatology. 43: 59-71. PMID 24446897 DOI: 10.1111/Jmp.12097 |
0.479 |
|
| 2014 |
Lin PL, Ford CB, Coleman MT, Myers AJ, Gawande R, Ioerger T, Sacchettini J, Fortune SM, Flynn JL. Sterilization of granulomas is common in active and latent tuberculosis despite within-host variability in bacterial killing. Nature Medicine. 20: 75-9. PMID 24336248 DOI: 10.1038/Nm.3412 |
0.46 |
|
| 2013 |
Kozakiewicz L, Chen Y, Xu J, Wang Y, Dunussi-Joannopoulos K, Ou Q, Flynn JL, Porcelli SA, Jacobs WR, Chan J. B cells regulate neutrophilia during Mycobacterium tuberculosis infection and BCG vaccination by modulating the interleukin-17 response. Plos Pathogens. 9: e1003472. PMID 23853593 DOI: 10.1371/Journal.Ppat.1003472 |
0.515 |
|
| 2013 |
Lin PL, Coleman T, Carney JP, Lopresti BJ, Tomko J, Fillmore D, Dartois V, Scanga C, Frye LJ, Janssen C, Klein E, Barry CE, Flynn JL. Radiologic responses in cynomolgous macaques for assessing tuberculosis chemotherapy regimens. Antimicrobial Agents and Chemotherapy. PMID 23796926 DOI: 10.1128/Aac.00277-13 |
0.694 |
|
| 2013 |
Via LE, Weiner DM, Schimel D, Lin PL, Dayao E, Tankersley SL, Cai Y, Coleman MT, Tomko J, Paripati P, Orandle M, Kastenmayer RJ, Tartakovsky M, Rosenthal A, Portevin D, ... ... Flynn JL, et al. Differential virulence and disease progression following Mycobacterium tuberculosis complex infection of the common marmoset (Callithrix jacchus). Infection and Immunity. 81: 2909-19. PMID 23716617 DOI: 10.1128/Iai.00632-13 |
0.445 |
|
| 2013 |
Diedrich CR, Mattila JT, Flynn JL. Monocyte-derived IL-5 reduces TNF production by Mycobacterium tuberculosis-specific CD4 T cells during SIV/M. tuberculosis coinfection. Journal of Immunology (Baltimore, Md. : 1950). 190: 6320-8. PMID 23690470 DOI: 10.4049/Jimmunol.1202043 |
0.845 |
|
| 2013 |
Myers AJ, Marino S, Kirschner DE, Flynn JL. Inoculation dose of Mycobacterium tuberculosis does not influence priming of T cell responses in lymph nodes. Journal of Immunology (Baltimore, Md. : 1950). 190: 4707-16. PMID 23547119 DOI: 10.4049/Jimmunol.1203465 |
0.426 |
|
| 2013 |
Ragheb MN, Ford CB, Chase MR, Lin PL, Flynn JL, Fortune SM. The mutation rate of mycobacterial repetitive unit loci in strains of M. tuberculosis from cynomolgus macaque infection. Bmc Genomics. 14: 145. PMID 23496945 DOI: 10.1186/1471-2164-14-145 |
0.426 |
|
| 2013 |
Kozakiewicz L, Phuah J, Flynn J, Chan J. The role of B cells and humoral immunity in Mycobacterium tuberculosis infection. Advances in Experimental Medicine and Biology. 783: 225-50. PMID 23468112 DOI: 10.1007/978-1-4614-6111-1_12 |
0.457 |
|
| 2013 |
Kozakiewicz L, Phuah J, Flynn J, Chan J. The role of B cells and humoral immunity in Mycobacterium tuberculosis infection. Advances in Experimental Medicine and Biology. 783: 225-50. PMID 23468112 DOI: 10.1007/978-1-4614-6111-1_12 |
0.457 |
|
| 2013 |
Green AM, Difazio R, Flynn JL. IFN-γ from CD4 T cells is essential for host survival and enhances CD8 T cell function during Mycobacterium tuberculosis infection. Journal of Immunology (Baltimore, Md. : 1950). 190: 270-7. PMID 23233724 DOI: 10.4049/Jimmunol.1200061 |
0.528 |
|
| 2012 |
Lin PL, Dartois V, Johnston PJ, Janssen C, Via L, Goodwin MB, Klein E, Barry CE, Flynn JL. Metronidazole prevents reactivation of latent Mycobacterium tuberculosis infection in macaques. Proceedings of the National Academy of Sciences of the United States of America. 109: 14188-93. PMID 22826237 DOI: 10.1073/Pnas.1121497109 |
0.523 |
|
| 2012 |
Robertson BD, Altmann D, Barry C, Bishai B, Cole S, Dick T, Duncan K, Dye C, Ehrt S, Esmail H, Flynn J, Hafner R, Handley G, Hanekom W, van Helden P, et al. Detection and treatment of subclinical tuberculosis. Tuberculosis (Edinburgh, Scotland). 92: 447-52. PMID 22819716 DOI: 10.1016/J.Tube.2012.06.004 |
0.412 |
|
| 2012 |
Kunnath-Velayudhan S, Davidow AL, Wang HY, Molina DM, Huynh VT, Salamon H, Pine R, Michel G, Perkins MD, Xiaowu L, Felgner PL, Flynn JL, Catanzaro A, Gennaro ML. Proteome-scale antibody responses and outcome of Mycobacterium tuberculosis infection in nonhuman primates and in tuberculosis patients. The Journal of Infectious Diseases. 206: 697-705. PMID 22732925 DOI: 10.1093/Infdis/Jis421 |
0.486 |
|
| 2012 |
Phuah JY, Mattila JT, Lin PL, Flynn JL. Activated B cells in the granulomas of nonhuman primates infected with Mycobacterium tuberculosis. The American Journal of Pathology. 181: 508-14. PMID 22721647 DOI: 10.1016/J.Ajpath.2012.05.009 |
0.541 |
|
| 2012 |
Via LE, Schimel D, Weiner DM, Dartois V, Dayao E, Cai Y, Yoon YS, Dreher MR, Kastenmayer RJ, Laymon CM, Carny JE, Flynn JL, Herscovitch P, Barry CE. Infection dynamics and response to chemotherapy in a rabbit model of tuberculosis using [¹⁸F]2-fluoro-deoxy-D-glucose positron emission tomography and computed tomography. Antimicrobial Agents and Chemotherapy. 56: 4391-402. PMID 22687508 DOI: 10.1128/Aac.00531-12 |
0.352 |
|
| 2012 |
Lin PL, Rutledge T, Green AM, Bigbee M, Fuhrman C, Klein E, Flynn JL. CD4 T cell depletion exacerbates acute Mycobacterium tuberculosis while reactivation of latent infection is dependent on severity of tissue depletion in cynomolgus macaques. Aids Research and Human Retroviruses. 28: 1693-702. PMID 22480184 DOI: 10.1089/Aid.2012.0028 |
0.485 |
|
| 2012 |
Fallahi-Sichani M, Flynn JL, Linderman JJ, Kirschner DE. Differential risk of tuberculosis reactivation among anti-TNF therapies is due to drug binding kinetics and permeability. Journal of Immunology (Baltimore, Md. : 1950). 188: 3169-78. PMID 22379032 DOI: 10.4049/Jimmunol.1103298 |
0.337 |
|
| 2012 |
Lin PL, Dietrich J, Tan E, Abalos RM, Burgos J, Bigbee C, Bigbee M, Milk L, Gideon HP, Rodgers M, Cochran C, Guinn KM, Sherman DR, Klein E, Janssen C, ... Flynn JL, et al. The multistage vaccine H56 boosts the effects of BCG to protect cynomolgus macaques against active tuberculosis and reactivation of latent Mycobacterium tuberculosis infection. The Journal of Clinical Investigation. 122: 303-14. PMID 22133873 DOI: 10.1172/Jci46252 |
0.499 |
|
| 2011 |
Zinman G, Brower-Sinning R, Emeche CH, Ernst J, Huang GT, Mahony S, Myers AJ, O'Dee DM, Flynn JL, Nau GJ, Ross TM, Salter RD, Benos PV, Bar Joseph Z, Morel PA. Large scale comparison of innate responses to viral and bacterial pathogens in mouse and macaque. Plos One. 6: e22401. PMID 21789257 DOI: 10.1371/Journal.Pone.0022401 |
0.399 |
|
| 2011 |
Gideon HP, Flynn JL. Latent tuberculosis: what the host "sees"? Immunologic Research. 50: 202-12. PMID 21717066 DOI: 10.1007/S12026-011-8229-7 |
0.557 |
|
| 2011 |
Ford CB, Lin PL, Chase MR, Shah RR, Iartchouk O, Galagan J, Mohaideen N, Ioerger TR, Sacchettini JC, Lipsitch M, Flynn JL, Fortune SM. Use of whole genome sequencing to estimate the mutation rate of Mycobacterium tuberculosis during latent infection. Nature Genetics. 43: 482-6. PMID 21516081 DOI: 10.1038/Ng.811 |
0.358 |
|
| 2011 |
Flynn JL, Chan J, Lin PL. Macrophages and control of granulomatous inflammation in tuberculosis Mucosal Immunology. 4: 271-278. PMID 21430653 DOI: 10.1038/Mi.2011.14 |
0.463 |
|
| 2011 |
Mattila JT, Diedrich CR, Lin PL, Phuah J, Flynn JL. Simian immunodeficiency virus-induced changes in T cell cytokine responses in cynomolgus macaques with latent Mycobacterium tuberculosis infection are associated with timing of reactivation. Journal of Immunology (Baltimore, Md. : 1950). 186: 3527-37. PMID 21317393 DOI: 10.4049/Jimmunol.1003773 |
0.835 |
|
| 2011 |
Diedrich CR, Flynn JL. HIV-1/mycobacterium tuberculosis coinfection immunology: how does HIV-1 exacerbate tuberculosis? Infection and Immunity. 79: 1407-17. PMID 21245275 DOI: 10.1128/Iai.01126-10 |
0.794 |
|
| 2010 |
Kirschner DE, Young D, Flynn JL. Tuberculosis: global approaches to a global disease. Current Opinion in Biotechnology. 21: 524-31. PMID 20637596 DOI: 10.1016/J.Copbio.2010.06.002 |
0.393 |
|
| 2010 |
Green AM, Mattila JT, Bigbee CL, Bongers KS, Lin PL, Flynn JL. CD4(+) regulatory T cells in a cynomolgus macaque model of Mycobacterium tuberculosis infection. The Journal of Infectious Diseases. 202: 533-41. PMID 20617900 DOI: 10.1086/654896 |
0.551 |
|
| 2010 |
Lin PL, Flynn JL. Understanding latent tuberculosis: a moving target. Journal of Immunology (Baltimore, Md. : 1950). 185: 15-22. PMID 20562268 DOI: 10.4049/Jimmunol.0903856 |
0.532 |
|
| 2010 |
Marino S, Myers A, Flynn JL, Kirschner DE. TNF and IL-10 are major factors in modulation of the phagocytic cell environment in lung and lymph node in tuberculosis: a next-generation two-compartmental model. Journal of Theoretical Biology. 265: 586-98. PMID 20510249 DOI: 10.1016/J.Jtbi.2010.05.012 |
0.455 |
|
| 2010 |
Russell DG, Barry CE, Flynn JL. Tuberculosis: what we don't know can, and does, hurt us. Science (New York, N.Y.). 328: 852-6. PMID 20466922 DOI: 10.1126/Science.1184784 |
0.466 |
|
| 2010 |
Scanga CA, Flynn JL. Mycobacterial infections and the inflammatory seesaw. Cell Host & Microbe. 7: 177-9. PMID 20227659 DOI: 10.1016/J.Chom.2010.03.003 |
0.647 |
|
| 2010 |
Diedrich CR, Mattila JT, Klein E, Janssen C, Phuah J, Sturgeon TJ, Montelaro RC, Lin PL, Flynn JL. Reactivation of latent tuberculosis in cynomolgus macaques infected with SIV is associated with early peripheral T cell depletion and not virus load. Plos One. 5: e9611. PMID 20224771 DOI: 10.1371/Journal.Pone.0009611 |
0.835 |
|
| 2010 |
Lin PL, Myers A, Smith L, Bigbee C, Bigbee M, Fuhrman C, Grieser H, Chiosea I, Voitenek NN, Capuano SV, Klein E, Flynn JL. Tumor necrosis factor neutralization results in disseminated disease in acute and latent Mycobacterium tuberculosis infection with normal granuloma structure in a cynomolgus macaque model. Arthritis and Rheumatism. 62: 340-50. PMID 20112395 DOI: 10.1002/Art.27271 |
0.456 |
|
| 2010 |
Perry S, de Jong BC, Solnick JV, de la Luz Sanchez M, Yang S, Lin PL, Hansen LM, Talat N, Hill PC, Hussain R, Adegbola RA, Flynn J, Canfield D, Parsonnet J. Infection with Helicobacter pylori is associated with protection against tuberculosis. Plos One. 5: e8804. PMID 20098711 DOI: 10.1371/Journal.Pone.0008804 |
0.49 |
|
| 2010 |
Barry CE, Boshoff HI, Dartois V, Dick T, Ehrt S, Flynn J, Schnappinger D, Wilkinson RJ, Young D. Spectrum of latent tuberculosis existing tests cannot resolve the underlying phenotypes: Author's reply Nature Reviews Microbiology. 8: 242. DOI: 10.1038/Nrmicro2236-C2 |
0.381 |
|
| 2009 |
Barry CE, Boshoff HI, Dartois V, Dick T, Ehrt S, Flynn J, Schnappinger D, Wilkinson RJ, Young D. The spectrum of latent tuberculosis: rethinking the biology and intervention strategies. Nature Reviews. Microbiology. 7: 845-55. PMID 19855401 DOI: 10.1038/Nrmicro2236 |
0.438 |
|
| 2009 |
Einarsdottir T, Lockhart E, Flynn JL. Cytotoxicity and secretion of gamma interferon are carried out by distinct CD8 T cells during Mycobacterium tuberculosis infection. Infection and Immunity. 77: 4621-30. PMID 19667047 DOI: 10.1128/Iai.00415-09 |
0.847 |
|
| 2009 |
Lin PL, Rodgers M, Smith L, Bigbee M, Myers A, Bigbee C, Chiosea I, Capuano SV, Fuhrman C, Klein E, Flynn JL. Quantitative comparison of active and latent tuberculosis in the cynomolgus macaque model. Infection and Immunity. 77: 4631-42. PMID 19620341 DOI: 10.1128/Iai.00592-09 |
0.517 |
|
| 2009 |
Windish HP, Lin PL, Mattila JT, Green AM, Onuoha EO, Kane LP, Flynn JL. Aberrant TGF-beta signaling reduces T regulatory cells in ICAM-1-deficient mice, increasing the inflammatory response to Mycobacterium tuberculosis. Journal of Leukocyte Biology. 86: 713-25. PMID 19454651 DOI: 10.1189/Jlb.1208740 |
0.404 |
|
| 2009 |
Ray JC, Flynn JL, Kirschner DE. Synergy between individual TNF-dependent functions determines granuloma performance for controlling Mycobacterium tuberculosis infection. Journal of Immunology (Baltimore, Md. : 1950). 182: 3706-17. PMID 19265149 DOI: 10.4049/Jimmunol.0802297 |
0.474 |
|
| 2008 |
Pawar SN, Mattila JT, Sturgeon TJ, Lin PL, Narayan O, Montelaro RC, Flynn JL. Comparison of the effects of pathogenic simian human immunodeficiency virus strains SHIV-89.6P and SHIV-KU2 in cynomolgus macaques. Aids Research and Human Retroviruses. 24: 643-54. PMID 18366326 DOI: 10.1089/Aid.2007.0238 |
0.482 |
|
| 2008 |
Via LE, Lin PL, Ray SM, Carrillo J, Allen SS, Eum SY, Taylor K, Klein E, Manjunatha U, Gonzales J, Lee EG, Park SK, Raleigh JA, Cho SN, McMurray DN, ... Flynn JL, et al. Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates. Infection and Immunity. 76: 2333-40. PMID 18347040 DOI: 10.1128/Iai.01515-07 |
0.405 |
|
| 2008 |
Lerche NW, Yee JL, Capuano SV, Flynn JL. New approaches to tuberculosis surveillance in nonhuman primates. Ilar Journal / National Research Council, Institute of Laboratory Animal Resources. 49: 170-8. PMID 18323579 DOI: 10.1093/Ilar.49.2.170 |
0.491 |
|
| 2008 |
Chakravarty SD, Zhu G, Tsai MC, Mohan VP, Marino S, Kirschner DE, Huang L, Flynn J, Chan J. Tumor necrosis factor blockade in chronic murine tuberculosis enhances granulomatous inflammation and disorganizes granulomas in the lungs. Infection and Immunity. 76: 916-26. PMID 18212087 DOI: 10.1128/Iai.01011-07 |
0.37 |
|
| 2008 |
Khan IH, Ravindran R, Yee J, Ziman M, Lewinsohn DM, Gennaro ML, Flynn JL, Goulding CW, DeRiemer K, Lerche NW, Luciw PA. Profiling antibodies to Mycobacterium tuberculosis by multiplex microbead suspension arrays for serodiagnosis of tuberculosis. Clinical and Vaccine Immunology : Cvi. 15: 433-8. PMID 18077619 DOI: 10.1128/Cvi.00354-07 |
0.43 |
|
| 2008 |
Riggs T, Walts A, Perry N, Bickle L, Lynch JN, Myers A, Flynn J, Linderman JJ, Miller MJ, Kirschner DE. A comparison of random vs. chemotaxis-driven contacts of T cells with dendritic cells during repertoire scanning. Journal of Theoretical Biology. 250: 732-51. PMID 18068193 DOI: 10.1016/J.Jtbi.2007.10.015 |
0.376 |
|
| 2008 |
Lin PL, Bigbee C, Matilla J, Samuels A, Casino S, Litvin D, Smith L, Kerr J, Tomko J, Reimann KA, Klein E, Flynn J. CD8 T cells are critical for control of acute M. tuberculosis infection in the non‐human primate The Faseb Journal. 22: 497-497. DOI: 10.1096/Fasebj.22.2_Supplement.497 |
0.543 |
|
| 2007 |
Marino S, Sud D, Plessner H, Lin PL, Chan J, Flynn JL, Kirschner DE. Differences in reactivation of tuberculosis induced from anti-TNF treatments are based on bioavailability in granulomatous tissue. Plos Computational Biology. 3: 1909-24. PMID 17953477 DOI: 10.1371/Journal.Pcbi.0030194 |
0.327 |
|
| 2007 |
Pegu A, Flynn JL, Reinhart TA. Afferent and efferent interfaces of lymph nodes are distinguished by expression of lymphatic endothelial markers and chemokines. Lymphatic Research and Biology. 5: 91-103. PMID 17935477 DOI: 10.1089/Lrb.2007.1006 |
0.416 |
|
| 2007 |
Bigbee CL, Gonchoroff DG, Vratsanos G, Nadler SG, Haggerty HG, Flynn JL. Abatacept treatment does not exacerbate chronic Mycobacterium tuberculosis infection in mice. Arthritis and Rheumatism. 56: 2557-65. PMID 17665452 DOI: 10.1002/Art.22750 |
0.505 |
|
| 2007 |
Dann FJ, Gottlieb AB, Deepe GS, Flynn JL, Wallis RS, Thompson EH, Louie JS. Structural-functional relationships of TNF-alpha antagonists: next steps. The Journal of Investigative Dermatology. Symposium Proceedings / the Society For Investigative Dermatology, Inc. [and] European Society For Dermatological Research. 12: 46-7. PMID 17502869 DOI: 10.1038/Sj.Jidsymp.5650028 |
0.326 |
|
| 2007 |
Lin PL, Plessner HL, Voitenok NN, Flynn JL. Tumor necrosis factor and tuberculosis. The Journal of Investigative Dermatology. Symposium Proceedings / the Society For Investigative Dermatology, Inc. [and] European Society For Dermatological Research. 12: 22-5. PMID 17502865 DOI: 10.1038/Sj.Jidsymp.5650027 |
0.49 |
|
| 2007 |
Plessner HL, Lin PL, Kohno T, Louie JS, Kirschner D, Chan J, Flynn JL. Neutralization of tumor necrosis factor (TNF) by antibody but not TNF receptor fusion molecule exacerbates chronic murine tuberculosis. The Journal of Infectious Diseases. 195: 1643-50. PMID 17471434 DOI: 10.1086/517519 |
0.385 |
|
| 2007 |
Chakravarty SD, Xu J, Lu B, Gerard C, Flynn J, Chan J. The chemokine receptor CXCR3 attenuates the control of chronic Mycobacterium tuberculosis infection in BALB/c mice Journal of Immunology. 178: 1723-1735. PMID 17237422 DOI: 10.4049/Jimmunol.178.3.1723 |
0.502 |
|
| 2006 |
Morel PA, Ta'asan S, Morel BF, Kirschner DE, Flynn JL. New insights into mathematical modeling of the immune system. Immunologic Research. 36: 157-65. PMID 17337776 DOI: 10.1385/Ir:36:1:157 |
0.312 |
|
| 2006 |
Lockhart E, Green AM, Flynn JL. IL-17 production is dominated by gammadelta T cells rather than CD4 T cells during Mycobacterium tuberculosis infection. Journal of Immunology (Baltimore, Md. : 1950). 177: 4662-9. PMID 16982905 DOI: 10.4049/Jimmunol.177.7.4662 |
0.439 |
|
| 2006 |
Lin PL, Pawar S, Myers A, Pegu A, Fuhrman C, Reinhart TA, Capuano SV, Klein E, Flynn JL. Early events in Mycobacterium tuberculosis infection in cynomolgus macaques. Infection and Immunity. 74: 3790-803. PMID 16790751 DOI: 10.1128/Iai.00064-06 |
0.576 |
|
| 2006 |
Sud D, Bigbee C, Flynn JL, Kirschner DE. Contribution of CD8+ T cells to control of Mycobacterium tuberculosis infection. Journal of Immunology (Baltimore, Md. : 1950). 176: 4296-314. PMID 16547267 DOI: 10.4049/Jimmunol.176.7.4296 |
0.514 |
|
| 2006 |
Flynn JL. Lessons from experimental Mycobacterium tuberculosis infections. Microbes and Infection / Institut Pasteur. 8: 1179-88. PMID 16513383 DOI: 10.1016/J.Micinf.2005.10.033 |
0.499 |
|
| 2006 |
Tsai MC, Chakravarty S, Zhu G, Xu J, Tanaka K, Koch C, Tufariello J, Flynn J, Chan J. Characterization of the tuberculous granuloma in murine and human lungs: cellular composition and relative tissue oxygen tension. Cellular Microbiology. 8: 218-32. PMID 16441433 DOI: 10.1111/J.1462-5822.2005.00612.X |
0.394 |
|
| 2006 |
Haggerty GH, Bahrt K, Bigbee C, Gonchoroff DG, Flynn JL. ABATACEPT TREATMENT DOES NOT IMPAIR HOST RESISTANCE TO CHRONIC MYCOBACTERIUM TUBERCULOSIS INFECTION IN MICE Jcr: Journal of Clinical Rheumatology. 12: S47-S48. DOI: 10.1097/01.rhu.0000226599.07908.6e |
0.331 |
|
| 2005 |
Lazarevic V, Nolt D, Flynn JL. Long-term control of Mycobacterium tuberculosis infection is mediated by dynamic immune responses. Journal of Immunology (Baltimore, Md. : 1950). 175: 1107-17. PMID 16002712 DOI: 10.4049/Jimmunol.175.2.1107 |
0.698 |
|
| 2005 |
Algood HM, Lin PL, Flynn JL. Tumor necrosis factor and chemokine interactions in the formation and maintenance of granulomas in tuberculosis. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 41: S189-93. PMID 15983898 DOI: 10.1086/429994 |
0.539 |
|
| 2005 |
Lazarevic V, Pawar S, Flynn J. Measuring T-cell function in animal models of tuberculosis by ELISPOT. Methods in Molecular Biology (Clifton, N.J.). 302: 179-90. PMID 15937352 DOI: 10.1385/1-59259-903-6:179 |
0.704 |
|
| 2005 |
Myers AJ, Eilertson B, Fulton SA, Flynn JL, Canaday DH. The purinergic P2X7 receptor is not required for control of pulmonary Mycobacterium tuberculosis infection. Infection and Immunity. 73: 3192-5. PMID 15845532 DOI: 10.1128/IAI.73.5.3192-3195.2005 |
0.373 |
|
| 2005 |
Lazarevic V, Yankura DJ, DiVito SJ, Flynn JL. Induction of Mycobacterium tuberculosis-specific primary and secondary T-cell responses in interleukin-15-deficient mice. Infection and Immunity. 73: 2910-22. PMID 15845497 DOI: 10.1128/Iai.73.5.2910-2922.2005 |
0.718 |
|
| 2005 |
Flynn JL, Chan J. What's good for the host is good for the bug. Trends in Microbiology. 13: 98-102. PMID 15737727 DOI: 10.1016/j.tim.2005.01.005 |
0.371 |
|
| 2005 |
Lin PL, Kirschner D, Flynn JL. Modeling pathogen and host: in vitro, in vivo and in silico models of latent Mycobacterium tuberculosis infection Drug Discovery Today: Disease Models. 2: 149-154. DOI: 10.1016/J.Ddmod.2005.05.019 |
0.474 |
|
| 2004 |
Algood HM, Flynn JL. CCR5-deficient mice control Mycobacterium tuberculosis infection despite increased pulmonary lymphocytic infiltration. Journal of Immunology (Baltimore, Md. : 1950). 173: 3287-96. PMID 15322191 DOI: 10.4049/Jimmunol.173.5.3287 |
0.497 |
|
| 2004 |
Marino S, Pawar S, Fuller CL, Reinhart TA, Flynn JL, Kirschner DE. Dendritic cell trafficking and antigen presentation in the human immune response to Mycobacterium tuberculosis. Journal of Immunology (Baltimore, Md. : 1950). 173: 494-506. PMID 15210810 DOI: 10.4049/Jimmunol.173.1.494 |
0.542 |
|
| 2004 |
Algood HM, Lin PL, Yankura D, Jones A, Chan J, Flynn JL. TNF influences chemokine expression of macrophages in vitro and that of CD11b+ cells in vivo during Mycobacterium tuberculosis infection. Journal of Immunology (Baltimore, Md. : 1950). 172: 6846-57. PMID 15153503 DOI: 10.4049/Jimmunol.172.11.6846 |
0.46 |
|
| 2004 |
Nolt D, Flynn JL. Interleukin-12 therapy reduces the number of immune cells and pathology in lungs of mice infected with Mycobacterium tuberculosis. Infection and Immunity. 72: 2976-88. PMID 15102810 |
0.413 |
|
| 2004 |
Chan J, Flynn J. The immunological aspects of latency in tuberculosis Clinical Immunology. 110: 2-12. PMID 14986673 DOI: 10.1016/S1521-6616(03)00210-9 |
0.428 |
|
| 2004 |
Flynn JL. Immunology of tuberculosis and implications in vaccine development. Tuberculosis (Edinburgh, Scotland). 84: 93-101. PMID 14670350 DOI: 10.1016/J.Tube.2003.08.010 |
0.537 |
|
| 2003 |
Lazarevic V, Myers AJ, Scanga CA, Flynn JL. CD40, but not CD40L, is required for the optimal priming of T cells and control of aerosol M. tuberculosis infection. Immunity. 19: 823-35. PMID 14670300 DOI: 10.1016/S1074-7613(03)00324-8 |
0.816 |
|
| 2003 |
Fuller CL, Flynn JL, Reinhart TA. In situ study of abundant expression of proinflammatory chemokines and cytokines in pulmonary granulomas that develop in cynomolgus macaques experimentally infected with Mycobacterium tuberculosis. Infection and Immunity. 71: 7023-34. PMID 14638792 DOI: 10.1128/Iai.71.12.7023-7034.2003 |
0.431 |
|
| 2003 |
Algood HM, Chan J, Flynn JL. Chemokines and tuberculosis. Cytokine & Growth Factor Reviews. 14: 467-77. PMID 14563349 DOI: 10.1016/S1359-6101(03)00054-6 |
0.437 |
|
| 2003 |
Capuano SV, Croix DA, Pawar S, Zinovik A, Myers A, Lin PL, Bissel S, Fuhrman C, Klein E, Flynn JL. Experimental Mycobacterium tuberculosis infection of cynomolgus macaques closely resembles the various manifestations of human M. tuberculosis infection Infection and Immunity. 71: 5831-5844. PMID 14500505 DOI: 10.1128/Iai.71.10.5831-5844.2003 |
0.531 |
|
| 2003 |
Tufariello JM, Chan J, Flynn JL. Latent tuberculosis: mechanisms of host and bacillus that contribute to persistent infection. The Lancet. Infectious Diseases. 3: 578-90. PMID 12954564 DOI: 10.1016/S1473-3099(03)00741-2 |
0.511 |
|
| 2003 |
Flynn JL, Chan J. Immune evasion by Mycobacterium tuberculosis: living with the enemy. Current Opinion in Immunology. 15: 450-5. PMID 12900278 DOI: 10.1016/S0952-7915(03)00075-X |
0.575 |
|
| 2003 |
Flynn JL, Capuano SV, Croix D, Pawar S, Myers A, Zinovik A, Klein E. Non-human primates: a model for tuberculosis research. Tuberculosis (Edinburgh, Scotland). 83: 116-8. PMID 12758200 DOI: 10.1016/S1472-9792(02)00059-8 |
0.515 |
|
| 2003 |
Board KF, Patil S, Lebedeva I, Capuano S, Trichel AM, Murphey-Corb M, Rajakumar PA, Flynn JL, Haidaris CG, Norris KA. Experimental Pneumocystis carinii pneumonia in simian immunodeficiency virus-infected rhesus macaques. The Journal of Infectious Diseases. 187: 576-88. PMID 12599074 DOI: 10.1086/373997 |
0.416 |
|
| 2002 |
Brennan PJ, Terwilliger T, Barry CE, Manca C, Su H, Reed M, Rutter K, Domenech P, Kaplan G, Li YJ, Wagner D, Bermudez LE, Bodnar K, Flynn J, Campos-Neto A, et al. The US-Japan Cooperative Medical Science Program Tuberculosis and Leprosy Panel's 36th annual research conference, New Orleans, Louisiana, USA, 15-17 July 2001 Tuberculosis. 82: 113-135. PMID 12408170 DOI: 10.1054/Tube.2002.0329 |
0.724 |
|
| 2002 |
Scott HM, Flynn JL. Mycobacterium tuberculosis in chemokine receptor 2-deficient mice: influence of dose on disease progression. Infection and Immunity. 70: 5946-54. PMID 12379669 DOI: 10.1128/Iai.70.11.5946-5954.2002 |
0.66 |
|
| 2002 |
Lazarevic V, Flynn J. CD8+ T cells in tuberculosis. American Journal of Respiratory and Critical Care Medicine. 166: 1116-21. PMID 12379557 DOI: 10.1164/Rccm.2204027 |
0.727 |
|
| 2002 |
Croix DA, Board K, Capuano S, Murphey-Corb M, Haidaris CG, Flynn JL, Reinhart T, Norris KA. Alterations in T lymphocyte profiles of bronchoalveolar lavage fluid from SIV- and Pneumocystis carinii-coinfected rhesus macaques. Aids Research and Human Retroviruses. 18: 391-401. PMID 11897041 DOI: 10.1089/088922202753519179 |
0.448 |
|
| 2001 |
Serbina NV, Lazarevic V, Flynn JL. CD4(+) T cells are required for the development of cytotoxic CD8(+) T cells during Mycobacterium tuberculosis infection. Journal of Immunology (Baltimore, Md. : 1950). 167: 6991-7000. PMID 11739519 DOI: 10.4049/Jimmunol.167.12.6991 |
0.816 |
|
| 2001 |
Scanga CA, Mohan VP, Tanaka K, Alland D, Flynn JL, Chan J. The inducible nitric oxide synthase locus confers protection against aerogenic challenge of both clinical and laboratory strains of Mycobacterium tuberculosis in mice. Infection and Immunity. 69: 7711-7. PMID 11705952 DOI: 10.1128/Iai.69.12.7711-7717.2001 |
0.732 |
|
| 2001 |
Peters W, Scott HM, Chambers HF, Flynn JL, Charo IF, Ernst JD. Chemokine receptor 2 serves an early and essential role in resistance to Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America. 98: 7958-63. PMID 11438742 DOI: 10.1073/Pnas.131207398 |
0.698 |
|
| 2001 |
Serbina NV, Flynn JL. CD8(+) T cells participate in the memory immune response to Mycobacterium tuberculosis. Infection and Immunity. 69: 4320-8. PMID 11401969 DOI: 10.1128/Iai.69.7.4320-4328.2001 |
0.778 |
|
| 2001 |
Chun T, Serbina NV, Nolt D, Wang B, Chiu NM, Flynn JL, Wang CR. Induction of M3-restricted cytotoxic T lymphocyte responses by N-formylated peptides derived from Mycobacterium tuberculosis. The Journal of Experimental Medicine. 193: 1213-20. PMID 11369792 DOI: 10.1084/Jem.193.10.1213 |
0.746 |
|
| 2001 |
Coler RN, Campos-Neto A, Ovendale P, Day FH, Fling SP, Zhu L, Serbina N, Flynn JL, Reed SG, Alderson MR. Vaccination with the T cell antigen Mtb 8.4 Protects against challenge with Mycobacterium tuberculosis Journal of Immunology. 166: 6227-6235. PMID 11342645 DOI: 10.4049/Jimmunol.166.10.6227 |
0.801 |
|
| 2001 |
Flynn JL, Chan J. Immunology of tuberculosis Annual Review of Immunology. 19: 93-129. PMID 11244032 DOI: 10.1146/Annurev.Immunol.19.1.93 |
0.563 |
|
| 2001 |
Mohan VP, Scanga CA, Yu K, Scott HM, Tanaka KE, Tsang E, Tsai MM, Flynn JL, Chan J. Effects of tumor necrosis factor alpha on host immune response in chronic persistent tuberculosis: possible role for limiting pathology. Infection and Immunity. 69: 1847-55. PMID 11179363 DOI: 10.1128/Iai.69.3.1847-1855.2001 |
0.748 |
|
| 2001 |
Bodnar KA, Serbina NV, Flynn JL. Fate of Mycobacterium tuberculosis within murine dendritic cells. Infection and Immunity. 69: 800-9. PMID 11159971 DOI: 10.1128/Iai.69.2.800-809.2001 |
0.776 |
|
| 2000 |
Croix DA, Capuano S, Simpson L, Fallert BA, Fuller CL, Klein EC, Reinhart TA, Murphey-Corb M, Flynn JL. Effect of mycobacterial infection on virus loads and disease progression in simian immunodeficiency virus-infected rhesus monkeys. Aids Research and Human Retroviruses. 16: 1895-908. PMID 11118075 DOI: 10.1089/08892220050195856 |
0.416 |
|
| 2000 |
Cho S, Mehra V, Thoma-Uszynski S, Stenger S, Serbina N, Mazzaccaro RJ, Flynn JL, Barnes PF, Southwood S, Celis E, Bloom BR, Modlin RL, Sette A. Antimicrobial activity of MHC class I-restricted CD8+ T cells in human tuberculosis. Proceedings of the National Academy of Sciences of the United States of America. 97: 12210-5. PMID 11035787 DOI: 10.1073/Pnas.210391497 |
0.78 |
|
| 2000 |
Scanga CA, Mohan VP, Yu K, Joseph H, Tanaka K, Chan J, Flynn JL. Depletion of CD4(+) T cells causes reactivation of murine persistent tuberculosis despite continued expression of interferon gamma and nitric oxide synthase 2. The Journal of Experimental Medicine. 192: 347-58. PMID 10934223 DOI: 10.1084/Jem.192.3.347 |
0.746 |
|
| 2000 |
Flynn JL, Ernst JD. Immune responses in tuberculosis Current Opinion in Immunology. 12: 432-436. PMID 10899019 DOI: 10.1016/S0952-7915(00)00116-3 |
0.536 |
|
| 2000 |
Serbina NV, Liu CC, Scanga CA, Flynn JL. CD8+ CTL from lungs of Mycobacterium tuberculosis-infected mice express perforin in vivo and lyse infected macrophages. Journal of Immunology (Baltimore, Md. : 1950). 165: 353-63. PMID 10861072 DOI: 10.4049/Jimmunol.165.1.353 |
0.856 |
|
| 1999 |
Flynn JL. Why is IFN-γ insufficient to control tuberculosis? [1] Trends in Microbiology. 7: 477-478. PMID 10603481 DOI: 10.1016/S0966-842X(99)01611-X |
0.435 |
|
| 1999 |
Scanga CA, Mohan VP, Joseph H, Yu K, Chan J, Flynn JL. Reactivation of latent tuberculosis: variations on the Cornell murine model. Infection and Immunity. 67: 4531-8. PMID 10456896 DOI: 10.1128/Iai.67.9.4531-4538.1999 |
0.751 |
|
| 1999 |
Serbina NV, Flynn JL. Early emergence of CD8(+) T cells primed for production of type 1 cytokines in the lungs of Mycobacterium tuberculosis-infected mice. Infection and Immunity. 67: 3980-8. PMID 10417164 DOI: 10.1128/Iai.67.8.3980-3988.1999 |
0.776 |
|
| 1998 |
Flynn JL, Scanga CA, Tanaka KE, Chan J. Effects of aminoguanidine on latent murine tuberculosis. Journal of Immunology (Baltimore, Md. : 1950). 160: 1796-803. PMID 9469439 |
0.72 |
|
| 1997 |
Flynn JL, Bloom BR. Role of T1 and T2 cytokines in the response to Mycobacterium tuberculosis. Annals of the New York Academy of Sciences. 795: 137-46. PMID 8958924 DOI: 10.1111/J.1749-6632.1996.Tb52662.X |
0.435 |
|
| 1995 |
Fennelly GJ, Flynn JL, ter Meulen V, Liebert UG, Bloom BR. Recombinant bacille Calmette-Guérin priming against measles. The Journal of Infectious Diseases. 172: 698-705. PMID 7658061 DOI: 10.1093/Infdis/172.3.698 |
0.308 |
|
| 1995 |
Flynn JL, Goldstein MM, Chan J, Triebold KJ, Pfeffer K, Lowenstein CJ, Schrelber R, Mak TW, Bloom BR. Tumor necrosis factor-α is required in the protective immune response against mycobacterium tuberculosis in mice Immunity. 2: 561-572. PMID 7540941 DOI: 10.1016/1074-7613(95)90001-2 |
0.355 |
|
| 1995 |
Cooper AM, Flynn JL. The protective immune response to Mycobacterium tuberculosis Current Opinion in Immunology. 7: 512-516. PMID 7495515 DOI: 10.1016/0952-7915(95)80096-4 |
0.478 |
|
| 1993 |
Flynn JL, Chan J, Triebold KJ, Dalton DK, Stewart TA, Bloom BR. An essential role for interferon γ in resistance to Mycobacterium tuberculosis infection Journal of Experimental Medicine. 178: 2249-2254. PMID 7504064 DOI: 10.1084/jem.178.6.2249 |
0.396 |
|
| 1993 |
Flynn JL, Goldstein MM, Triebold KJ, Koller B, Bloom BR. Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection. Proceedings of the National Academy of Sciences of the United States of America. 89: 12013-7. PMID 1465432 DOI: 10.1073/Pnas.89.24.12013 |
0.404 |
|
| Show low-probability matches. |