| Year |
Citation |
Score |
| 2016 |
Denis D, Rouleau C, Schaffhausen BS. A Transformation-Defective Polyomavirus Middle T Antigen with a Novel Defect in PI3 Kinase Signaling. Journal of Virology. PMID 27852846 DOI: 10.1128/JVI.01774-16 |
0.395 |
|
| 2016 |
Rouleau C, Pores Fernando AT, Hwang JH, Faure N, Jiang T, White EA, Roberts TM, Schaffhausen BS. Transformation by Polyomavirus Middle T Antigen Involves A Unique Bimodal Interaction with the Hippo Effector YAP. Journal of Virology. PMID 27194756 DOI: 10.1128/Jvi.00417-16 |
0.325 |
|
| 2014 |
Hwang JH, Pores Fernando AT, Faure N, Andrabi S, Hahn WC, Schaffhausen BS, Roberts TM. Polyomavirus small T antigen interacts with yes-associated protein to regulate cell survival and differentiation. Journal of Virology. 88: 12055-64. PMID 25122798 DOI: 10.1128/Jvi.01399-14 |
0.404 |
|
| 2013 |
Harrison C, Jiang T, Banerjee P, Meinke G, D'Abramo CM, Schaffhausen B, Bohm A. Polyomavirus large T antigen binds symmetrical repeats at the viral origin in an asymmetrical manner. Journal of Virology. 87: 13751-9. PMID 24109229 DOI: 10.1128/Jvi.01740-13 |
0.348 |
|
| 2013 |
Hwang JH, Jiang T, Kulkarni S, Faure N, Schaffhausen BS. Protein phosphatase 2A isoforms utilizing Aβ scaffolds regulate differentiation through control of Akt protein. The Journal of Biological Chemistry. 288: 32064-73. PMID 24052256 DOI: 10.1074/Jbc.M113.497644 |
0.352 |
|
| 2012 |
Miao B, Skidan I, Yang J, You Z, Fu X, Famulok M, Schaffhausen B, Torchilin V, Yuan J, Degterev A. Inhibition of cell migration by PITENINs: The role of ARF6 Oncogene. 31: 4317-4332. PMID 22179837 DOI: 10.1038/Onc.2011.593 |
0.369 |
|
| 2011 |
Andrabi S, Hwang JH, Choe JK, Roberts TM, Schaffhausen BS. Comparisons between murine polyomavirus and Simian virus 40 show significant differences in small T antigen function. Journal of Virology. 85: 10649-58. PMID 21835797 DOI: 10.1128/Jvi.05034-11 |
0.373 |
|
| 2011 |
Lee SH, Jia S, Zhu Y, Utermark T, Signoretti S, Loda M, Schaffhausen B, Roberts TM. Transgenic expression of polyomavirus middle T antigen in the mouse prostate gives rise to carcinoma. Journal of Virology. 85: 5581-92. PMID 21411524 DOI: 10.1128/Jvi.02609-10 |
0.544 |
|
| 2010 |
Miao B, Skidan I, Yang J, Lugovskoy A, Reibarkh M, Long K, Brazell T, Durugkar KA, Maki J, Ramana CV, Schaffhausen B, Wagner G, Torchilin V, Yuan J, Degterev A. Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains. Proceedings of the National Academy of Sciences of the United States of America. 107: 20126-31. PMID 21041639 DOI: 10.1073/Pnas.1004522107 |
0.383 |
|
| 2009 |
Knoblich K, Whittaker S, Ludwig C, Michiels P, Jiang T, Schaffhausen B, Günther U. Backbone assignment of the N-terminal polyomavirus large T antigen. Biomolecular Nmr Assignments. 3: 119-23. PMID 19636961 DOI: 10.1007/S12104-009-9155-7 |
0.425 |
|
| 2009 |
Cheng J, DeCaprio JA, Fluck MM, Schaffhausen BS. Cellular transformation by Simian Virus 40 and Murine Polyoma Virus T antigens. Seminars in Cancer Biology. 19: 218-28. PMID 19505649 DOI: 10.1016/J.Semcancer.2009.03.002 |
0.381 |
|
| 2009 |
Schaffhausen BS, Roberts TM. Lessons from polyoma middle T antigen on signaling and transformation: A DNA tumor virus contribution to the war on cancer. Virology. 384: 304-16. PMID 19022468 DOI: 10.1016/J.Virol.2008.09.042 |
0.373 |
|
| 2008 |
Siwko SK, Bu W, Gutierrez C, Lewis B, Jechlinger M, Schaffhausen B, Li Y. Lentivirus-mediated oncogene introduction into mammary cells in vivo induces tumors. Neoplasia (New York, N.Y.). 10: 653-62, 1 p followin. PMID 18592025 DOI: 10.1593/Neo.08266 |
0.318 |
|
| 2008 |
Whalen KA, Weber GF, Benjamin TL, Schaffhausen BS. Polyomavirus middle T antigen induces the transcription of osteopontin, a gene important for the migration of transformed cells. Journal of Virology. 82: 4946-54. PMID 18337582 DOI: 10.1128/Jvi.02650-07 |
0.326 |
|
| 2007 |
Andrabi S, Gjoerup OV, Kean JA, Roberts TM, Schaffhausen B. Protein phosphatase 2A regulates life and death decisions via Akt in a context-dependent manner. Proceedings of the National Academy of Sciences of the United States of America. 104: 19011-6. PMID 18006659 DOI: 10.1073/Pnas.0706696104 |
0.455 |
|
| 2007 |
Gjoerup OV, Wu J, Chandler-Militello D, Williams GL, Zhao J, Schaffhausen B, Jat PS, Roberts TM. Surveillance mechanism linking Bub1 loss to the p53 pathway. Proceedings of the National Academy of Sciences of the United States of America. 104: 8334-9. PMID 17488820 DOI: 10.1073/Pnas.0703164104 |
0.341 |
|
| 2007 |
Utermark T, Schaffhausen BS, Roberts TM, Zhao JJ. The p110alpha isoform of phosphatidylinositol 3-kinase is essential for polyomavirus middle T antigen-mediated transformation. Journal of Virology. 81: 7069-76. PMID 17442716 DOI: 10.1128/Jvi.00115-07 |
0.346 |
|
| 2007 |
Primo L, di Blasio L, Roca C, Droetto S, Piva R, Schaffhausen B, Bussolino F. Essential role of PDK1 in regulating endothelial cell migration. The Journal of Cell Biology. 176: 1035-47. PMID 17371830 DOI: 10.1083/Jcb.200607053 |
0.372 |
|
| 2006 |
Mittag T, Franzoni L, Cavazzini D, Schaffhausen B, Rossi GL, Günther UL. Retinol modulates site-specific mobility of apo-cellular retinol-binding protein to promote ligand binding. Journal of the American Chemical Society. 128: 9844-8. PMID 16866541 DOI: 10.1021/Ja0616128 |
0.339 |
|
| 2005 |
Love TM, de Jesus R, Kean JA, Sheng Q, Leger A, Schaffhausen B. Activation of CREB/ATF sites by polyomavirus large T antigen. Journal of Virology. 79: 4180-90. PMID 15767419 DOI: 10.1128/Jvi.79.7.4180-4190.2005 |
0.46 |
|
| 2004 |
Mittag T, Schaffhausen B, Günther UL. Tracing kinetic intermediates during ligand binding. Journal of the American Chemical Society. 126: 9017-23. PMID 15264834 DOI: 10.1021/Ja0392519 |
0.3 |
|
| 2003 |
Mittag T, Schaffhausen B, Günther UL. Direct observation of protein-ligand interaction kinetics. Biochemistry. 42: 11128-36. PMID 14503863 DOI: 10.1021/Bi0347499 |
0.353 |
|
| 2003 |
Günther UL, Weyrauch B, Zhang X, Schaffhausen B. Nuclear magnetic resonance structure of the P395S mutant of the N-SH2 domain of the p85 subunit of PI3 kinase: an SH2 domain with altered specificity. Biochemistry. 42: 11120-7. PMID 14503862 DOI: 10.1021/Bi034353X |
0.416 |
|
| 2003 |
Hong YK, Mikami A, Schaffhausen B, Jun T, Roberts TM. A new class of mutations reveals a novel function for the original phosphatidylinositol 3-kinase binding site. Proceedings of the National Academy of Sciences of the United States of America. 100: 9434-9. PMID 12881485 DOI: 10.1073/Pnas.1432964100 |
0.435 |
|
| 2002 |
Günther U, Mittag T, Schaffhausen B. Probing Src homology 2 domain ligand interactions by differential line broadening. Biochemistry. 41: 11658-69. PMID 12269808 DOI: 10.1021/Bi0202528 |
0.37 |
|
| 2002 |
Günther UL, Schaffhausen B. NMRKIN: simulating line shapes from two-dimensional spectra of proteins upon ligand binding. Journal of Biomolecular Nmr. 22: 201-9. PMID 11991351 DOI: 10.1023/A:1014985726029 |
0.352 |
|
| 2002 |
Tian X, Rusanescu G, Hou W, Schaffhausen B, Feig LA. PDK1 mediates growth factor-induced Ral-GEF activation by a kinase-independent mechanism. The Embo Journal. 21: 1327-38. PMID 11889038 DOI: 10.1093/Emboj/21.6.1327 |
0.422 |
|
| 2000 |
Weber T, Schaffhausen B, Liu Y, Günther UL. NMR structure of the N-SH2 of the p85 subunit of phosphoinositide 3-kinase complexed to a doubly phosphorylated peptide reveals a second phosphotyrosine binding site. Biochemistry. 39: 15860-15869. PMID 11123912 DOI: 10.1021/Bi001474D |
0.406 |
|
| 2000 |
Sheng Q, Love TM, Schaffhausen B. J domain-independent regulation of the Rb family by polyomavirus large T antigen. Journal of Virology. 74: 5280-90. PMID 10799605 DOI: 10.1128/Jvi.74.11.5280-5290.2000 |
0.429 |
|
| 1999 |
Yen A, Cherington V, Schaffhausen B, Marks K, Varvayanis S. Transformation-defective polyoma middle T antigen mutants defective in PLCgamma, PI-3, or src kinase activation enhance ERK2 activation and promote retinoic acid-induced, cell differentiation like wild-type middle T. Experimental Cell Research. 248: 538-51. PMID 10222145 DOI: 10.1006/Excr.1999.4423 |
0.461 |
|
| 1998 |
Mullane KP, Ratnofsky M, Culleré X, Schaffhausen B. Signaling from polyomavirus middle T and small T defines different roles for protein phosphatase 2A. Molecular and Cellular Biology. 18: 7556-64. PMID 9819441 DOI: 10.1128/Mcb.18.12.7556 |
0.496 |
|
| 1997 |
Sheng Q, Denis D, Ratnofsky M, Roberts TM, Decaprio JA, Schaffhausen B. The DnaJ domain of polyomavirus large T antigen is required to regulate Rb family tumor suppressor function Journal of Virology. 71: 9410-9416. PMID 9371601 DOI: 10.1128/Jvi.71.12.9410-9416.1997 |
0.43 |
|
| 1996 |
Günther UL, Liu Y, Sanford D, Bachovchin WW, Schaffhausen B. NMR analysis of interactions of a phosphatidylinositol 3'-kinase SH2 domain with phosphotyrosine peptides reveals interdependence of major binding sites. Biochemistry. 35: 15570-81. PMID 8952511 DOI: 10.1021/Bi961783X |
0.389 |
|
| 1995 |
Shin EK, Shin A, Paulding C, Schaffhausen B, Yee AS. Multiple change in E2F function and regulation occur upon muscle differentiation. Molecular and Cellular Biology. 15: 2252-62. PMID 7891719 DOI: 10.1128/Mcb.15.4.2252 |
0.36 |
|
| 1995 |
Schaffhausen B. SH2 domain structure and function Biochimica Et Biophysica Acta. 1242: 61-75. PMID 7542925 DOI: 10.1016/0304-419X(95)00004-Y |
0.432 |
|
| 1994 |
Yoakim M, Hou W, Songyang Z, Liu Y, Cantley L, Schaffhausen B. Genetic analysis of a phosphatidylinositol 3-kinase SH2 domain reveals determinants of specificity. Molecular and Cellular Biology. 14: 5929-5938. PMID 8065326 DOI: 10.1128/Mcb.14.9.5929 |
0.49 |
|
| 1993 |
Carpenter CL, Auger KR, Duckworth BC, Hou WM, Schaffhausen B, Cantley LC. A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity. Molecular and Cellular Biology. 13: 1657-65. PMID 8382773 DOI: 10.1128/Mcb.13.3.1657 |
0.439 |
|
| 1993 |
Soltoff SP, Carpenter CL, Auger KR, Kapeller R, Schaffhausen B, Cantley LC. Phosphatidylinositol-3 kinase and growth regulation. Cold Spring Harbor Symposia On Quantitative Biology. 57: 75-80. PMID 1339706 DOI: 10.1101/Sqb.1992.057.01.010 |
0.361 |
|
| 1992 |
Myers MG, Backer JM, Sun XJ, Shoelson S, Hu P, Schlessinger J, Yoakim M, Schaffhausen B, White MF. IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85. Proceedings of the National Academy of Sciences of the United States of America. 89: 10350-4. PMID 1332046 DOI: 10.1073/Pnas.89.21.10350 |
0.441 |
|
| 1991 |
Marsilio E, Cheng SH, Schaffhausen B, Paucha E, Livingston DM. The T/t common region of simian virus 40 large T antigen contains a distinct transformation-governing sequence Journal of Virology. 65: 5647-5652. PMID 1654462 DOI: 10.1128/Jvi.65.10.5647-5652.1991 |
0.424 |
|
| 1989 |
Gelinas C, Schaffhausen B, Bockus B, Ratiarson A, Bastin M. Mutations in polyomavirus middle T antigen affecting tumorigenesis Virology. 170: 193-200. PMID 2470192 DOI: 10.1016/0042-6822(89)90366-8 |
0.438 |
|
| 1989 |
Kaplan DR, Pallas DC, Morgan W, Schaffhausen B, Roberts TM. Mechanisms of transformation by polyoma virus middle T antigen Bba - Reviews On Cancer. 948: 345-364. PMID 2465782 DOI: 10.1016/0304-419X(89)90006-1 |
0.436 |
|
| 1988 |
Roberts TM, Kaplan D, Morgan W, Keller T, Mamon H, Piwnica-Worms H, Druker B, Cohen B, Schaffhausen B, Whitman M, Cantley L, Rapp U, Morrison D. Tyrosine phosphorylation in signal transduction Cold Spring Harbor Symposia On Quantitative Biology. 53: 161-171. PMID 2855480 DOI: 10.1101/Sqb.1988.053.01.022 |
0.354 |
|
| 1988 |
Pallas DC, Cherington V, Morgan W, DeAnda J, Kaplan D, Schaffhausen B, Roberts TM. Cellular proteins that associate with the middle and small T antigens of polyomavirus Journal of Virology. 62: 3934-3940. PMID 2845116 DOI: 10.1128/Jvi.62.11.3934-3940.1988 |
0.344 |
|
| 1987 |
Bockus BJ, Schaffhausen B. Localization of the phosphorylations of polyomavirus large T antigen. Journal of Virology. 61: 1155-1163. PMID 3029410 DOI: 10.1128/Jvi.61.4.1155-1163.1987 |
0.448 |
|
| 1987 |
Bockus BJ, Schaffhausen B. Phosphorylation of polyomavirus large T antigen: effects of viral mutations and cell growth state. Journal of Virology. 61: 1147-1154. PMID 3029409 DOI: 10.1128/Jvi.61.4.1147-1154.1987 |
0.441 |
|
| 1987 |
Kaplan DR, Whitman M, Schaffhausen B, Pallas DC, White M, Cantley L, Roberts TM. Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity Cell. 50: 1021-1029. PMID 2441878 DOI: 10.1016/0092-8674(87)90168-1 |
0.466 |
|
| 1986 |
Kaplan DR, Whitman M, Schaffhausen B, Raptis L, Garcea RL, Pallas D, Roberts TM, Cantley L. Phosphatidylinositol metabolism and polyoma-mediated transformation. Proceedings of the National Academy of Sciences of the United States of America. 83: 3624-8. PMID 2424008 DOI: 10.1073/Pnas.83.11.3624 |
0.428 |
|
| 1985 |
Schaffhausen B, Benjamin TL, Lodge J, Kaplan D, Roberts TM. Expression of polyoma early gene products in E. coli. Nucleic Acids Research. 13: 501-19. PMID 2987799 DOI: 10.1093/Nar/13.2.501 |
0.424 |
|
| 1985 |
Whitman M, Kaplan DR, Schaffhausen B, Cantley L, Roberts TM. Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation. Nature. 315: 239-42. PMID 2987699 DOI: 10.1038/315239A0 |
0.466 |
|
| 1984 |
Zhu ZY, Veldman GM, Cowie A, Carr A, Schaffhausen B, Kamen R. Construction and functional characterization of polyomavirus genomes that separately encode the three early proteins. Journal of Virology. 51: 170-180. PMID 6328036 DOI: 10.1128/Jvi.51.1.170-180.1984 |
0.401 |
|
| 1984 |
Mes-Masson AM, Schaffhausen B, Hassell JA. The major site of tyrosine phosphorylation in polyomavirus middle T antigen is not required for transformation. Journal of Virology. 52: 457-64. PMID 6092671 DOI: 10.1128/Jvi.52.2.457-464.1984 |
0.42 |
|
| 1981 |
Schaffhausen B, Benjamin TL. Comparison of phosphorylation of two polyoma virus middle T antigens in vivo and in vitro. Journal of Virology. 40: 184-96. PMID 6169848 DOI: 10.1128/Jvi.40.1.184-196.1981 |
0.439 |
|
| 1979 |
Silver J, Schaffhausen B, Benjamin T. Tumor antigens induced by nontransforming mutants of polyoma virus. Cell. 15: 485-96. PMID 214241 DOI: 10.1016/0092-8674(78)90018-1 |
0.387 |
|
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