Todd W. Vanderah - Publications

Affiliations: 
University of Arizona, Tucson, AZ 
Area:
Pain, opioids, pharmacology

173 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Liktor-Busa E, Blawn KT, Kellohen KL, Wiese BM, Verkhovsky V, Wahl J, Vivek A, Palomino SM, Davis TP, Vanderah TW, Largent-Milnes TM. Functional NHE1 expression is critical to blood brain barrier integrity and sumatriptan blood to brain uptake. Plos One. 15: e0227463. PMID 32469979 DOI: 10.1371/journal.pone.0227463  0.96
2020 Doyle TM, Largent-Milnes TM, Chen Z, Staikopoulos V, Esposito E, Delgarno R, Fan C, Tosh DK, Cuzzocrea S, Jacobson KA, Trang T, Hutchinson MR, Bennett GJ, Vanderah TW, Salvemini D. The Journal of Pharmacology and Experimental Therapeutics. PMID 32434943 DOI: 10.1124/jpet.120.000004  0.96
2020 Lucarini E, Coppi E, Micheli L, Parisio C, Vona A, Cherchi F, Pugliese AM, Pedata F, Failli P, Palomino S, Wahl J, Largent-Milnes TM, Vanderah TW, Tosh DK, Jacobson KA, et al. Acute visceral pain relief mediated by A3AR agonists in rats: involvement of N-type voltage-gated calcium channels. Pain. PMID 32379223 DOI: 10.1097/j.pain.0000000000001905  0.96
2020 Doyle TM, Janes K, Chen Z, Grace PM, Esposito E, Cuzzocrea S, Largent-Milnes TM, Neumann WL, Watkins LR, Spiegel S, Vanderah TW, Salvemini D. Activation of sphingosine-1-phosphate receptor subtype 1 in the central nervous system contributes to morphine-induced hyperalgesia and antinociceptive tolerance in rodents. Pain. PMID 32301840 DOI: 10.1097/j.pain.0000000000001888  0.96
2020 Thompson AL, Grenald S, Ciccone H, BassiriRad N, Niphakis M, Cravatt B, Largent-Milnes TM, Vanderah TW. The Endocannabinoid System Alleviates Pain in a Murine Model of Cancer-Induced Bone Pain. The Journal of Pharmacology and Experimental Therapeutics. PMID 32054717 DOI: 10.1124/jpet.119.262337  0.96
2019 Khanna R, Patwardhan A, Yang X, Li W, Cai S, Ji Y, Chew LA, Dorame A, Bellampalli SS, Schmoll RW, Gordon J, Moutal A, Vanderah TW, Porreca F, Ibrahim MM. Erratum to ‛Development and Characterization of An Injury-free Model of Functional Pain in Rats by Exposure to Red Light': The Journal of Pain 20 (2019) 1293-1306. The Journal of Pain : Official Journal of the American Pain Society. 20: 1509. PMID 31818395 DOI: 10.1016/j.jpain.2019.11.012  1
2019 Zhang H, Largent-Milnes TM, Vanderah TW. Glial Neuroimmune Signaling in Opioid Reward. Brain Research Bulletin. PMID 31790721 DOI: 10.1016/j.brainresbull.2019.11.012  0.96
2019 Johnston CB, Vanderah T. Lost in the Haze: The Physician's Role in Cannabinoid Prescribing and Advising. The American Journal of Medicine. PMID 31251905 DOI: 10.1016/j.amjmed.2019.05.049  0.4
2019 Moutal A, Luo S, Largent-Milnes TM, Vanderah TW, Khanna R. Cdk5-mediated CRMP2 phosphorylation is necessary and sufficient for peripheral neuropathic pain. Neurobiology of Pain (Cambridge, Mass.). 5. PMID 31080913 DOI: 10.1016/j.ynpai.2018.07.003  0.96
2019 Chen Z, Doyle TM, Luongo L, Largent-Milnes TM, Giancotti LA, Kolar G, Squillace S, Boccella S, Walker JK, Pendleton A, Spiegel S, Neumann WL, Vanderah TW, Salvemini D. Sphingosine-1-phosphate receptor 1 activation in astrocytes contributes to neuropathic pain. Proceedings of the National Academy of Sciences of the United States of America. PMID 31068460 DOI: 10.1073/pnas.1820466116  0.96
2019 Khanna R, Patwardhan A, Yang X, Li W, Cai S, Ji Y, Chew LA, Dorame A, Bellampalli SS, Schmoll RW, Gordon J, Moutal A, Vanderah TW, Porreca F, Ibrahim MM. Development and Characterization of An Injury-free Model of Functional Pain in Rats by Exposure to Red Light. The Journal of Pain : Official Journal of the American Pain Society. PMID 31054915 DOI: 10.1016/j.jpain.2019.04.008  1
2019 Thompson AL, Largent-Milnes TM, Vanderah TW. Animal Models for the Study of Bone-Derived Pain. Methods in Molecular Biology (Clifton, N.J.). 1914: 391-407. PMID 30729479 DOI: 10.1007/978-1-4939-8997-3_23  0.96
2019 Hay M, Polt R, Heien ML, Vanderah TW, Largen-Milnes TM, Rodgers KE, Falk T, Bartlett MJ, Doyle K, Konhilas J. A Novel Angiotensin-(1-7)-glycosylated Mas Receptor Agonist for Treating Vascular Cognitive Impairment and Inflammation Related Memory Dysfunction. The Journal of Pharmacology and Experimental Therapeutics. PMID 30709867 DOI: 10.1124/jpet.118.254854  0.64
2018 Cottier KE, Galloway EA, Calabrese EC, Tome ME, Liktor-Busa E, Kim J, Davis TP, Vanderah TW, Largent-Milnes TM. Loss of Blood-Brain Barrier Integrity in a KCl-Induced Model of Episodic Headache Enhances CNS Drug Delivery. Eneuro. 5. PMID 30073201 DOI: 10.1523/ENEURO.0116-18.2018  0.96
2018 Zhang H, Lund DM, Ciccone HA, Staatz WD, Ibrahim MM, Largent-Milnes TM, Seltzman HH, Spigelman I, Vanderah TW. A peripherally restricted cannabinoid 1 receptor agonist as a novel analgesic in cancer-induced bone pain. Pain. PMID 29781960 DOI: 10.1097/j.pain.0000000000001278  0.96
2018 Pandit V, Khan M, Zakaria ER, Largent-Milnes TM, Hamidi M, O'Keeffe T, Vanderah TW, Joseph B. Continuous Remote Ischemic Conditioning Attenuates Cognitive and Motor Deficits From Moderate Traumatic Brain Injury. The Journal of Trauma and Acute Care Surgery. PMID 29443855 DOI: 10.1097/TA.0000000000001835  0.96
2018 Edwards KA, Havelin JJ, Mcintosh MI, Ciccone HA, Pangilinan K, Imbert I, Largent-Milnes TM, King T, Vanderah TW, Streicher JM. A Kappa Opioid Receptor Agonist Blocks Bone Cancer Pain Without Altering Bone Loss, Tumor Size, or Cancer Cell Proliferation in a Mouse Model of Cancer-Induced Bone Pain. The Journal of Pain : Official Journal of the American Pain Society. PMID 29371114 DOI: 10.1016/j.jpain.2018.01.002  0.96
2017 Sandweiss AJ, Cottier KE, McIntosh MI, Dussor G, Davis TP, Vanderah TW, Largent-Milnes TM. 17-β-Estradiol induces spreading depression and pain behavior in alert female rats. Oncotarget. 8: 114109-114122. PMID 29371973 DOI: 10.18632/oncotarget.23141  1
2017 Malekzadeh P, Hu J, Sandweiss AJ, Ameli N, Bierny P, Largent-Milnes TM, Vanderah TW, Shirazi F. Effect of Centruroides antivenom on reversal of methamphetamine-induced hyperkinesis and hyperthermia in rats. Journal of Pharmaceutics & Pharmacology. 5. PMID 29354652 DOI: 10.13188/2327-204X.1000020  1
2017 Moutal A, Wang Y, Yang X, Ji Y, Luo S, Dorame A, Bellampalli SS, Chew LA, Cai S, Dustrude ET, Keener JE, Marty MT, Vanderah TW, Khanna R. Dissecting the role of the CRMP2-Neurofibromin complex on pain behaviors. Pain. PMID 28767512 DOI: 10.1097/j.pain.0000000000001026  0.68
2017 Sandweiss AJ, Azim A, Ibraheem K, Largent-Milnes TM, Rhee P, Vanderah TW, Joseph B. Remote Ischemic Conditioning Preserves Cognition and Motor Coordination in a Mouse Model of Traumatic Brain Injury. The Journal of Trauma and Acute Care Surgery. PMID 28609381 DOI: 10.1097/TA.0000000000001626  1
2017 Grenald SA, Doyle TM, Zhang H, Slosky LM, Chen Z, Largent-Milnes TM, Spiegel S, Vanderah TW, Salvemini D. Targeting the S1P/S1PR1 axis mitigates cancer-induced bone pain and neuroinflammation. Pain. PMID 28570482 DOI: 10.1097/j.pain.0000000000000965  0.96
2017 Moutal A, Li W, Wang Y, Ju W, Luo S, Cai S, François-Moutal L, Perez-Miller S, Hu J, Dustrude ET, Vanderah TW, Gokhale V, Khanna M, Khanna R. Homology-guided mutational analysis reveals the functional requirements for antinociceptive specificity of CRMP2-derived peptides. British Journal of Pharmacology. PMID 28161890 DOI: 10.1111/bph.13737  0.68
2017 Ibrahim MM, Patwardhan A, Gilbraith KB, Moutal A, Yang X, Chew LA, Largent-Milnes T, Malan TP, Vanderah TW, Porreca F, Khanna R. Long-lasting antinociceptive effects of green light in acute and chronic pain in rats. Pain. 158: 347-360. PMID 28092651 DOI: 10.1097/j.pain.0000000000000767  1
2017 Hay M, Vanderah TW, Samareh-Jahani F, Constantopoulos E, Uprety AR, Barnes CA, Konhilas J. Cognitive Impairment in Heart Failure: A Protective Role for Angiotensin-(1-7). Behavioral Neuroscience. PMID 28054808 DOI: 10.1037/bne0000182  0.64
2016 Grenald SA, Young MA, Wang Y, Ossipov MH, Ibrahim MM, Largent-Milnes TM, Vanderah TW. Synergistic attenuation of chronic pain using mu opioid and cannabinoid receptor 2 agonists. Neuropharmacology. PMID 28007501 DOI: 10.1016/j.neuropharm.2016.12.008  0.96
2016 Ramos-Colon CN, Lee YS, Remesic MV, Hall SM, LaVigne J, Davis P, Sandweiss AJ, McIntosh MI, Hanson J, Largent-Milnes TM, Vanderah TW, Streicher JM, Porreca F, Hruby VJ. Structure Activity Relationships of [des-Arg(7)]- Dynorphin A Analogues at the Kappa Opioid Receptor. Journal of Medicinal Chemistry. PMID 27797517 DOI: 10.1021/acs.jmedchem.6b01411  1
2016 Forte BL, Slosky LM, Zhang H, Arnold M, Staatz WD, Hay M, Largent-Milnes TM, Vanderah TW. Angiotensin-(1-7)/Mas Receptor as an Antinociceptive Agent in Cancer-Induced Bone Pain. Pain. PMID 27541850 DOI: 10.1097/j.pain.0000000000000690  0.96
2016 Xie JY, Chew LA, Yang X, Wang Y, Qu C, Wang Y, Federici LM, Fitz SD, Ripsch MS, Due MR, Moutal A, Khanna M, White FA, Vanderah TW, Johnson PL, et al. Sustained relief of ongoing experimental neuropathic pain by a CRMP2 peptide aptamer with low abuse potential. Pain. 157: 2124-2140. PMID 27537210 DOI: 10.1097/j.pain.0000000000000628  0.52
2016 Slosky LM, BassiriRad NM, Symons AM, Thompson M, Doyle T, Forte BL, Staatz WD, Bui L, Neumann WL, Mantyh PW, Salvemini D, Largent-Milnes TM, Vanderah TW. The Cystine/Glutamate Antiporter System xc- Drives Breast Tumor Cell Glutamate Release and Cancer-Induced Bone Pain. Pain. PMID 27482630 DOI: 10.1097/j.pain.0000000000000681  0.96
2016 Hanlon KE, Lozano-Ondoua AN, Umaretiya PJ, Symons-Liguori AM, Chandramouli A, Moy JK, Kwass WK, Mantyh PW, Nelson MA, Vanderah TW. Modulation of breast cancer cell viability by a cannabinoid receptor 2 agonist, JWH-015, is calcium dependent. Breast Cancer (Dove Medical Press). 8: 59-71. PMID 27186076 DOI: 10.2147/BCTT.S100393  0.52
2016 Moutal A, Chew LA, Yang X, Wang Y, Yeon SK, Telemi E, Meroueh S, Park KD, Shrinivasan R, Gilbraith KB, Qu C, Xie JY, Patwardhan A, Vanderah TW, Khanna M, et al. (S)-Lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology. Pain. PMID 26967696 DOI: 10.1097/j.pain.0000000000000555  0.52
2015 Deekonda S, Rankin D, Davis P, Lai J, Vanderah TW, Porecca F, Hruby VJ. Design synthesis and structure-activity relationship of 5-substituted (tetrahydronaphthalen-2yl)methyl with N-phenyl-N-(piperidin-2-yl)propionamide derivatives as opioid ligands. Bioorganic & Medicinal Chemistry. PMID 26712115 DOI: 10.1016/j.bmc.2015.11.030  0.68
2015 Deekonda S, Cole J, Sunna S, Rankin D, Largent-Milnes TM, Davis P, BassiriRad NM, Lai J, Vanderah TW, Porecca F, Hruby VJ. Enkephalin analogues with N-phenyl-N-(piperidin-2-ylmethyl)propionamide derivatives: Synthesis and biological evaluations. Bioorganic & Medicinal Chemistry Letters. PMID 26611918 DOI: 10.1016/j.bmcl.2015.10.081  1
2015 Giri AK, Apostol CR, Wang Y, Forte BL, Largent-Milnes TM, Davis P, Rankin D, Molnar G, Olson KM, Porreca F, Vanderah TW, Hruby VJ. Discovery of Novel Multifunctional Ligands with μ/δ Opioid Agonist/Neurokinin-1 (NK1) Antagonist Activities for the Treatment of Pain. Journal of Medicinal Chemistry. PMID 26465170 DOI: 10.1021/acs.jmedchem.5b01170  1
2015 Sandweiss AJ, Vanderah TW. The pharmacology of neurokinin receptors in addiction: prospects for therapy. Substance Abuse and Rehabilitation. 6: 93-102. PMID 26379454 DOI: 10.2147/SAR.S70350  1
2015 Slosky LM, Largent-Milnes TM, Vanderah TW. Use of Animal Models in Understanding Cancer-induced Bone Pain. Cancer Growth and Metastasis. 8: 47-62. PMID 26339191 DOI: 10.4137/CGM.S21215  0.96
2015 Deekonda S, Wugalter L, Rankin D, Largent-Milnes TM, Davis P, Wang Y, Bassirirad NM, Lai J, Kulkarni V, Vanderah TW, Porreca F, Hruby VJ. Design and synthesis of novel bivalent ligands (MOR and DOR) by conjugation of enkephalin analogues with 4-anilidopiperidine derivatives. Bioorganic & Medicinal Chemistry Letters. PMID 26323872 DOI: 10.1016/j.bmcl.2015.07.064  1
2015 Deekonda S, Wugalter L, Kulkarni V, Rankin D, Largent-Milnes TM, Davis P, Bassirirad NM, Lai J, Vanderah TW, Porreca F, Hruby VJ. Discovery of 5-substituted tetrahydronaphthalen-2yl-methyl with N-phenyl-N-(piperidin-4-yl)propionamide derivatives as potent opioid receptor ligands. Bioorganic & Medicinal Chemistry. 23: 6185-94. PMID 26299827 DOI: 10.1016/j.bmc.2015.07.071  1
2015 Lee YS, Hall SM, Ramos-Colon C, Remesic M, Rankin D, Vanderah TW, Porreca F, Lai J, Hruby VJ. Blockade of non-opioid excitatory effects of spinal dynorphin A at bradykinin receptors. Receptors & Clinical Investigation. 2. PMID 26221618 DOI: 10.14800/rci.517  1
2015 Nair P, Yamamoto T, Cowell S, Kulkarni V, Moye S, Navratilova E, Davis P, Ma SW, Vanderah TW, Lai J, Porreca F, Hruby VJ. Discovery of tripeptide-derived multifunctional ligands possessing delta/mu opioid receptor agonist and neurokinin 1 receptor antagonist activities. Bioorganic & Medicinal Chemistry Letters. 25: 3716-20. PMID 26212775 DOI: 10.1016/j.bmcl.2015.06.030  1
2015 Ford A, Castonguay A, Cottet M, Little JW, Chen Z, Symons-Liguori AM, Doyle T, Egan TM, Vanderah TW, De Konnick Y, Tosh DK, Jacobson KA, Salvemini D. Engagement of the GABA to KCC2 signaling pathway contributes to the analgesic effects of A3AR agonists in neuropathic pain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 6057-67. PMID 25878279 DOI: 10.1523/JNEUROSCI.4495-14.2015  1
2015 François-Moutal L, Wang Y, Moutal A, Cottier KE, Melemedjian OK, Yang X, Wang Y, Ju W, Largent-Milnes TM, Khanna M, Vanderah TW, Khanna R. A membrane-delimited N-myristoylated CRMP2 peptide aptamer inhibits CaV2.2 trafficking and reverses inflammatory and postoperative pain behaviors. Pain. 156: 1247-64. PMID 25782368 DOI: 10.1097/j.pain.0000000000000147  1
2015 Slosky LM, Vanderah TW. Therapeutic potential of peroxynitrite decomposition catalysts: a patent review. Expert Opinion On Therapeutic Patents. 25: 443-66. PMID 25576197 DOI: 10.1517/13543776.2014.1000862  1
2015 Dzierlenga AL, Clarke JD, Hargraves TL, Ainslie GR, Vanderah TW, Paine MF, Cherrington NJ. Mechanistic basis of altered morphine disposition in nonalcoholic steatohepatitis. The Journal of Pharmacology and Experimental Therapeutics. 352: 462-70. PMID 25512370 DOI: 10.1124/jpet.114.220764  1
2015 Little JW, Ford A, Symons-Liguori AM, Chen Z, Janes K, Doyle T, Xie J, Luongo L, Tosh DK, Maione S, Bannister K, Dickenson AH, Vanderah TW, Porreca F, Jacobson KA, et al. Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states. Brain : a Journal of Neurology. 138: 28-35. PMID 25414036 DOI: 10.1093/brain/awu330  1
2015 Deekonda S, Wugalter L, Kulkarni V, Rankin D, Largent-Milnes TM, Davis P, Bassirirad NM, Lai J, Vanderah TW, Porreca F, Hruby VJ. Discovery of 5-substituted tetrahydronaphthalen-2yl-methyl with N-phenyl-N-(piperidin-4-yl)propionamide derivatives as potent opioid receptor ligands Bioorganic and Medicinal Chemistry. 23: 6185-6194. DOI: 10.1016/j.bmc.2015.07.071  1
2015 King T, Porreca F, Vanderah TW. Opioid-induced hyperalgesia and cancer pain: Effects on tumor growth and disease progression Cancer Pain: From Molecules to Suffering 0.52
2014 Grenald SA, Largent-Milnes TM, Vanderah TW. Animal models for opioid addiction drug discovery. Expert Opinion On Drug Discovery. 9: 1345-54. PMID 25307021 DOI: 10.1517/17460441.2014.966076  1
2014 Lee YS, Muthu D, Hall SM, Ramos-Colon C, Rankin D, Hu J, Sandweiss AJ, De Felice M, Xie JY, Vanderah TW, Porreca F, Lai J, Hruby VJ. Discovery of amphipathic dynorphin A analogues to inhibit the neuroexcitatory effects of dynorphin A through bradykinin receptors in the spinal cord. Journal of the American Chemical Society. 136: 6608-16. PMID 24742335 DOI: 10.1021/ja501677q  1
2013 Podolsky AT, Sandweiss A, Hu J, Bilsky EJ, Cain JP, Kumirov VK, Lee YS, Hruby VJ, Vardanyan RS, Vanderah TW. Novel fentanyl-based dual μ/δ-opioid agonists for the treatment of acute and chronic pain. Life Sciences. 93: 1010-6. PMID 24084045 DOI: 10.1016/j.lfs.2013.09.016  1
2013 Lozano-Ondoua AN, Symons-Liguori AM, Vanderah TW. Cancer-induced bone pain: Mechanisms and models. Neuroscience Letters. 557: 52-9. PMID 24076008 DOI: 10.1016/j.neulet.2013.08.003  1
2013 Slosky LM, Thompson BJ, Sanchez-Covarrubias L, Zhang Y, Laracuente ML, Vanderah TW, Ronaldson PT, Davis TP. Acetaminophen modulates P-glycoprotein functional expression at the blood-brain barrier by a constitutive androstane receptor-dependent mechanism. Molecular Pharmacology. 84: 774-86. PMID 24019224 DOI: 10.1124/mol.113.086298  1
2013 Nair P, Yamamoto T, Largent-Milnes TM, Cowell S, Kulkarni V, Moye S, Navratilova E, Davis P, Ma SW, Vanderah TW, Lai J, Porreca F, Hruby VJ. Truncation of the peptide sequence in bifunctional ligands with mu and delta opioid receptor agonist and neurokinin 1 receptor antagonist activities. Bioorganic & Medicinal Chemistry Letters. 23: 4975-8. PMID 23899615 DOI: 10.1016/j.bmcl.2013.06.065  1
2013 Largent-Milnes TM, Brookshire SW, Skinner DP, Hanlon KE, Giuvelis D, Yamamoto T, Davis P, Campos CR, Nair P, Deekonda S, Bilsky EJ, Porreca F, Hruby VJ, Vanderah TW. Building a better analgesic: multifunctional compounds that address injury-induced pathology to enhance analgesic efficacy while eliminating unwanted side effects. The Journal of Pharmacology and Experimental Therapeutics. 347: 7-19. PMID 23860305 DOI: 10.1124/jpet.113.205245  1
2013 Petrov RR, Lee YS, Vardanyan RS, Liu L, Ma SW, Davis P, Lai J, Porreca F, Vanderah TW, Hruby VJ. Effect of anchoring 4-anilidopiperidines to opioid peptides. Bioorganic & Medicinal Chemistry Letters. 23: 3434-7. PMID 23623418 DOI: 10.1016/j.bmcl.2013.03.065  1
2013 Lozano-Ondoua AN, Hanlon KE, Symons-Liguori AM, Largent-Milnes TM, Havelin JJ, Ferland HL, Chandramouli A, Owusu-Ankomah M, Nikolich-Zugich T, Bloom AP, Jimenez-Andrade JM, King T, Porreca F, Nelson MA, Mantyh PW, ... Vanderah TW, et al. Disease modification of breast cancer-induced bone remodeling by cannabinoid 2 receptor agonists. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 28: 92-107. PMID 22903605 DOI: 10.1002/jbmr.1732  1
2013 Symons-Liguori AM, Vanderah TW. The delta opioid receptor Acs Symposium Series. 1131: 223-244. DOI: 10.1021/bk-2013-1131.ch012  1
2012 Edelmayer RM, Le LN, Yan J, Wei X, Nassini R, Materazzi S, Preti D, Appendino G, Geppetti P, Dodick DW, Vanderah TW, Porreca F, Dussor G. Activation of TRPA1 on dural afferents: a potential mechanism of headache pain. Pain. 153: 1949-58. PMID 22809691 DOI: 10.1016/j.pain.2012.06.012  1
2012 Tumati S, Largent-Milnes TM, Keresztes AI, Yamamoto T, Vanderah TW, Roeske WR, Hruby VJ, Varga EV. Tachykinin NK₁ receptor antagonist co-administration attenuates opioid withdrawal-mediated spinal microglia and astrocyte activation. European Journal of Pharmacology. 684: 64-70. PMID 22724132 DOI: 10.1016/j.ejphar.2012.03.025  1
2012 De Felice M, Melchiorri P, Ossipov MH, Vanderah TW, Porreca F, Negri L. Mechanisms of Bv8-induced biphasic hyperalgesia: increased excitatory transmitter release and expression. Neuroscience Letters. 521: 40-5. PMID 22641053 DOI: 10.1016/j.neulet.2012.05.055  1
2012 Pajouhesh H, Feng ZP, Zhang L, Pajouhesh H, Jiang X, Hendricson A, Dong H, Tringham E, Ding Y, Vanderah TW, Porreca F, Belardetti F, Zamponi GW, Mitscher LA, Snutch TP. Structure-activity relationships of trimethoxybenzyl piperazine N-type calcium channel inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 4153-8. PMID 22579422 DOI: 10.1016/j.bmcl.2012.04.054  1
2012 Tumati S, Largent-Milnes TM, Keresztes A, Ren J, Roeske WR, Vanderah TW, Varga EV. Repeated morphine treatment-mediated hyperalgesia, allodynia and spinal glial activation are blocked by co-administration of a selective cannabinoid receptor type-2 agonist. Journal of Neuroimmunology. 244: 23-31. PMID 22285397 DOI: 10.1016/j.jneuroim.2011.12.021  1
2012 Marshall TM, Herman DS, Largent-Milnes TM, Badghisi H, Zuber K, Holt SC, Lai J, Porreca F, Vanderah TW. Activation of descending pain-facilitatory pathways from the rostral ventromedial medulla by cholecystokinin elicits release of prostaglandin-Eâ‚‚ in the spinal cord. Pain. 153: 86-94. PMID 22030324 DOI: 10.1016/j.pain.2011.09.021  1
2012 Lozano-Ondoua AN, Vanderah TW. Emerging analgesics and future directions: Targeting neuroplasticity Analgesics For Cancer Pain. 95-101. DOI: 10.2217/EBO.11.377  0.68
2011 Sukhtankar D, Okun A, Chandramouli A, Nelson MA, Vanderah TW, Cress AE, Porreca F, King T. Inhibition of p38-MAPK signaling pathway attenuates breast cancer induced bone pain and disease progression in a murine model of cancer-induced bone pain. Molecular Pain. 7: 81. PMID 22014040 DOI: 10.1186/1744-8069-7-81  1
2011 Vardanyan R, Kumirov VK, Nichol GS, Davis P, Liktor-Busa E, Rankin D, Varga E, Vanderah T, Porreca F, Lai J, Hruby VJ. Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligands. Bioorganic & Medicinal Chemistry. 19: 6135-42. PMID 21925887 DOI: 10.1016/j.bmc.2011.08.027  1
2011 De Felice M, Sanoja R, Wang R, Vera-Portocarrero L, Oyarzo J, King T, Ossipov MH, Vanderah TW, Lai J, Dussor GO, Fields HL, Price TJ, Porreca F. Engagement of descending inhibition from the rostral ventromedial medulla protects against chronic neuropathic pain. Pain. 152: 2701-9. PMID 21745713 DOI: 10.1016/j.pain.2011.06.008  1
2011 Fioravanti B, Kasasbeh A, Edelmayer R, Skinner DP, Hartings JA, Burklund RD, De Felice M, French ED, Dussor GO, Dodick DW, Porreca F, Vanderah TW. Evaluation of cutaneous allodynia following induction of cortical spreading depression in freely moving rats. Cephalalgia : An International Journal of Headache. 31: 1090-100. PMID 21700643 DOI: 10.1177/0333102411410609  1
2011 Tumati S, Roeske WR, Largent-Milnes TM, Vanderah TW, Varga EV. Intrathecal PKA-selective siRNA treatment blocks sustained morphine-mediated pain sensitization and antinociceptive tolerance in rats. Journal of Neuroscience Methods. 199: 62-8. PMID 21571003 DOI: 10.1016/j.jneumeth.2011.04.036  1
2011 Hanlon KE, Herman DS, Agnes RS, Largent-Milnes TM, Kumarasinghe IR, Ma SW, Guo W, Lee YS, Ossipov MH, Hruby VJ, Lai J, Porreca F, Vanderah TW. Novel peptide ligands with dual acting pharmacophores designed for the pathophysiology of neuropathic pain. Brain Research. 1395: 1-11. PMID 21550594 DOI: 10.1016/j.brainres.2011.04.024  1
2011 Stagg NJ, Mata HP, Ibrahim MM, Henriksen EJ, Porreca F, Vanderah TW, Philip Malan T. Regular exercise reverses sensory hypersensitivity in a rat neuropathic pain model: role of endogenous opioids. Anesthesiology. 114: 940-8. PMID 21386701 DOI: 10.1097/ALN.0b013e318210f880  1
2011 Yamamoto T, Nair P, Largent-Milnes TM, Jacobsen NE, Davis P, Ma SW, Yamamura HI, Vanderah TW, Porreca F, Lai J, Hruby VJ. Discovery of a potent and efficacious peptide derivative for δ/μ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies. Journal of Medicinal Chemistry. 54: 2029-38. PMID 21366266 DOI: 10.1021/jm101023r  1
2011 Lee YS, Kulkarani V, Cowell SM, Ma SW, Davis P, Hanlon KE, Vanderah TW, Lai J, Porreca F, Vardanyan R, Hruby VJ. Development of potent μ and δ opioid agonists with high lipophilicity. Journal of Medicinal Chemistry. 54: 382-6. PMID 21128594 DOI: 10.1021/jm100982d  1
2010 Hanlon KE, Vanderah TW. Constitutive activity at the cannabinoid CB(1) receptor and behavioral responses. Methods in Enzymology. 484: 3-30. PMID 21036224 DOI: 10.1016/B978-0-12-381298-8.00001-0  1
2010 Largent-Milnes TM, Yamamoto T, Nair P, Moulton JW, Hruby VJ, Lai J, Porreca F, Vanderah TW. Spinal or systemic TY005, a peptidic opioid agonist/neurokinin 1 antagonist, attenuates pain with reduced tolerance. British Journal of Pharmacology. 161: 986-1001. PMID 20977451 DOI: 10.1111/j.1476-5381.2010.00824.x  1
2010 Tumati S, Roeske WR, Vanderah TW, Varga EV. Sustained morphine treatment augments prostaglandin E2-evoked calcitonin gene-related peptide release from primary sensory neurons in a PKA-dependent manner. European Journal of Pharmacology. 648: 95-101. PMID 20826131 DOI: 10.1016/j.ejphar.2010.08.042  1
2010 Tumati S, Roeske WR, Largent-Milnes T, Wang R, Vanderah TW, Varga EV. Sustained morphine-mediated pain sensitization and antinociceptive tolerance are blocked by intrathecal treatment with Raf-1-selective siRNA. British Journal of Pharmacology. 161: 51-64. PMID 20718739 DOI: 10.1111/j.1476-5381.2010.00869.x  1
2010 Yamamoto T, Nair P, Jacobsen NE, Kulkarni V, Davis P, Ma SW, Navratilova E, Yamamura HI, Vanderah TW, Porreca F, Lai J, Hruby VJ. Biological and conformational evaluation of bifunctional compounds for opioid receptor agonists and neurokinin 1 receptor antagonists possessing two penicillamines. Journal of Medicinal Chemistry. 53: 5491-501. PMID 20617791 DOI: 10.1021/jm100157m  1
2010 De Felice M, Ossipov MH, Wang R, Lai J, Chichorro J, Meng I, Dodick DW, Vanderah TW, Dussor G, Porreca F. Triptan-induced latent sensitization: a possible basis for medication overuse headache. Annals of Neurology. 67: 325-37. PMID 20373344 DOI: 10.1002/ana.21897  1
2010 Largent-Milnes TM, Vanderah TW. Recently patented and promising ORL-1 ligands: where have we been and where are we going? Expert Opinion On Therapeutic Patents. 20: 291-305. PMID 20180617 DOI: 10.1517/13543771003602004  1
2010 Lozano-Ondoua AN, Wright C, Vardanyan A, King T, Largent-Milnes TM, Nelson M, Jimenez-Andrade JM, Mantyh PW, Vanderah TW. A cannabinoid 2 receptor agonist attenuates bone cancer-induced pain and bone loss. Life Sciences. 86: 646-53. PMID 20176037 DOI: 10.1016/j.lfs.2010.02.014  1
2010 Pajouhesh H, Feng ZP, Ding Y, Zhang L, Pajouhesh H, Morrison JL, Belardetti F, Tringham E, Simonson E, Vanderah TW, Porreca F, Zamponi GW, Mitscher LA, Snutch TP. Structure-activity relationships of diphenylpiperazine N-type calcium channel inhibitors. Bioorganic & Medicinal Chemistry Letters. 20: 1378-83. PMID 20117000 DOI: 10.1016/j.bmcl.2010.01.008  1
2010 Vanderah TW. Delta and kappa opioid receptors as suitable drug targets for pain. The Clinical Journal of Pain. 26: S10-5. PMID 20026960 DOI: 10.1097/AJP.0b013e3181c49e3a  1
2010 Jimenez-Andrade JM, Mantyh WG, Bloom AP, Xu H, Ferng AS, Dussor G, Vanderah TW, Mantyh PW. A phenotypically restricted set of primary afferent nerve fibers innervate the bone versus skin: therapeutic opportunity for treating skeletal pain. Bone. 46: 306-13. PMID 19766746 DOI: 10.1016/j.bone.2009.09.013  1
2009 Yamamoto T, Nair P, Jacobsen NE, Vagner J, Kulkarni V, Davis P, Ma SW, Navratilova E, Yamamura HI, Vanderah TW, Porreca F, Lai J, Hruby VJ. Improving metabolic stability by glycosylation: bifunctional peptide derivatives that are opioid receptor agonists and neurokinin 1 receptor antagonists. Journal of Medicinal Chemistry. 52: 5164-75. PMID 20560643 DOI: 10.1021/jm900473p  1
2009 King T, Vera-Portocarrero L, Gutierrez T, Vanderah TW, Dussor G, Lai J, Fields HL, Porreca F. Unmasking the tonic-aversive state in neuropathic pain. Nature Neuroscience. 12: 1364-6. PMID 19783992 DOI: 10.1038/nn.2407  1
2009 Yamamoto T, Nair P, Ma SW, Davis P, Yamamura HI, Vanderah TW, Porreca F, Lai J, Hruby VJ. The biological activity and metabolic stability of peptidic bifunctional compounds that are opioid receptor agonists and neurokinin-1 receptor antagonists with a cystine moiety. Bioorganic & Medicinal Chemistry. 17: 7337-43. PMID 19762245 DOI: 10.1016/j.bmc.2009.08.035  1
2009 Vardanyan R, Vijay G, Nichol GS, Liu L, Kumarasinghe I, Davis P, Vanderah T, Porreca F, Lai J, Hruby VJ. Synthesis and investigations of double-pharmacophore ligands for treatment of chronic and neuropathic pain. Bioorganic & Medicinal Chemistry. 17: 5044-53. PMID 19540763 DOI: 10.1016/j.bmc.2009.05.065  1
2009 Tumati S, Yamamura HI, Vanderah TW, Roeske WR, Varga EV. Sustained morphine treatment augments capsaicin-evoked calcitonin gene-related peptide release from primary sensory neurons in a protein kinase A- and Raf-1-dependent manner. The Journal of Pharmacology and Experimental Therapeutics. 330: 810-7. PMID 19491327 DOI: 10.1124/jpet.109.151704  1
2009 Nair P, Yamamoto T, Kulkarni V, Moye S, Navratilova E, Davis P, Largent T, Ma SW, Yamamura HI, Vanderah T, Lai J, Porreca F, Hruby VJ. Novel bifunctional peptides as opioid agonists and NK-1 antagonists. Advances in Experimental Medicine and Biology. 611: 537-8. PMID 19400302 DOI: 10.1007/978-0-387-73657-0_235  1
2009 Lee Y, Petrov R, Kulkarni V, Min BJ, Ma SW, Davis P, Oyarzo J, Vanderah T, Lai J, Porreca F, Vardanyan R, Hruby VJ. Development of mu/delta opioid ligands: enkephalin analogues containing 4-anilidopiperidine moiety. Advances in Experimental Medicine and Biology. 611: 517-8. PMID 19400292 DOI: 10.1007/978-0-387-73657-0_225  1
2009 Tumati S, Yamamura HI, St John PA, Vanderah TW, Roeske WR, Varga EV. Sustained cannabinoid agonist treatment augments CGRP release in a PKA-dependent manner. Neuroreport. 20: 815-9. PMID 19387418 DOI: 10.1097/WNR.0b013e32832be50b  1
2009 Edelmayer RM, Vanderah TW, Majuta L, Zhang ET, Fioravanti B, De Felice M, Chichorro JG, Ossipov MH, King T, Lai J, Kori SH, Nelsen AC, Cannon KE, Heinricher MM, Porreca F. Medullary pain facilitating neurons mediate allodynia in headache-related pain. Annals of Neurology. 65: 184-93. PMID 19259966 DOI: 10.1002/ana.21537  1
2009 Porreca F, Vanderah TW. Spring pain research conference 2008. Brain Research Reviews. 60: 1. PMID 19150467 DOI: 10.1016/j.brainresrev.2008.12.022  1
2009 Stein C, Clark JD, Oh U, Vasko MR, Wilcox GL, Overland AC, Vanderah TW, Spencer RH. Peripheral mechanisms of pain and analgesia. Brain Research Reviews. 60: 90-113. PMID 19150465 DOI: 10.1016/j.brainresrev.2008.12.017  1
2009 Zhang W, Gardell S, Zhang D, Xie JY, Agnes RS, Badghisi H, Hruby VJ, Rance N, Ossipov MH, Vanderah TW, Porreca F, Lai J. Neuropathic pain is maintained by brainstem neurons co-expressing opioid and cholecystokinin receptors. Brain : a Journal of Neurology. 132: 778-87. PMID 19050032 DOI: 10.1093/brain/awn330  1
2009 Vardanyan A, Wang R, Vanderah TW, Ossipov MH, Lai J, Porreca F, King T. TRPV1 receptor in expression of opioid-induced hyperalgesia. The Journal of Pain : Official Journal of the American Pain Society. 10: 243-52. PMID 18774343 DOI: 10.1016/j.jpain.2008.07.004  1
2008 Fioravanti B, Vanderah TW. The ORL-1 receptor system: are there opportunities for antagonists in pain therapy? Current Topics in Medicinal Chemistry. 8: 1442-51. PMID 18991730 DOI: 10.2174/156802608786264227  1
2008 Fioravanti B, De Felice M, Stucky CL, Medler KA, Luo MC, Gardell LR, Ibrahim M, Malan TP, Yamamura HI, Ossipov MH, King T, Lai J, Porreca F, Vanderah TW. Constitutive activity at the cannabinoid CB1 receptor is required for behavioral response to noxious chemical stimulation of TRPV1: antinociceptive actions of CB1 inverse agonists. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 11593-602. PMID 18987195 DOI: 10.1523/JNEUROSCI.3322-08.2008  1
2008 Tumati S, Milnes TL, Yamamura HI, Vanderah TW, Roeske WR, Varga EV. Intrathecal Raf-1-selective siRNA attenuates sustained morphine-mediated thermal hyperalgesia. European Journal of Pharmacology. 601: 207-8. PMID 18976650 DOI: 10.1016/j.ejphar.2008.10.033  1
2008 Yamamoto T, Nair P, Jacobsen NE, Davis P, Ma SW, Navratilova E, Moye S, Lai J, Yamamura HI, Vanderah TW, Porreca F, Hruby VJ. The importance of micelle-bound states for the bioactivities of bifunctional peptide derivatives for delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists. Journal of Medicinal Chemistry. 51: 6334-47. PMID 18821747 DOI: 10.1021/jm800389v  1
2008 Largent-Milnes TM, Guo W, Wang HY, Burns LH, Vanderah TW. Oxycodone plus ultra-low-dose naltrexone attenuates neuropathic pain and associated mu-opioid receptor-Gs coupling. The Journal of Pain : Official Journal of the American Pain Society. 9: 700-13. PMID 18468954 DOI: 10.1016/j.jpain.2008.03.005  1
2008 Wang R, King T, Ossipov MH, Rossomando AJ, Vanderah TW, Harvey P, Cariani P, Frank E, Sah DW, Porreca F. Persistent restoration of sensory function by immediate or delayed systemic artemin after dorsal root injury. Nature Neuroscience. 11: 488-96. PMID 18344995 DOI: 10.1038/nn2069  1
2008 Yue X, Tumati S, Navratilova E, Strop D, St John PA, Vanderah TW, Roeske WR, Yamamura HI, Varga EV. Sustained morphine treatment augments basal CGRP release from cultured primary sensory neurons in a Raf-1 dependent manner. European Journal of Pharmacology. 584: 272-7. PMID 18328477 DOI: 10.1016/j.ejphar.2008.02.013  1
2008 Vanderah TW, Largent-Milnes T, Lai J, Porreca F, Houghten RA, Menzaghi F, Wisniewski K, Stalewski J, Sueiras-Diaz J, Galyean R, Schteingart C, Junien JL, Trojnar J, Rivière PJ. Novel D-amino acid tetrapeptides produce potent antinociception by selectively acting at peripheral kappa-opioid receptors. European Journal of Pharmacology. 583: 62-72. PMID 18282565 DOI: 10.1016/j.ejphar.2008.01.011  1
2008 Yamamoto T, Nair P, Vagner J, Largent-Milnes T, Davis P, Ma SW, Navratilova E, Moye S, Tumati S, Lai J, Yamamura HI, Vanderah TW, Porreca F, Hruby VJ. A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists. Journal of Medicinal Chemistry. 51: 1369-76. PMID 18266313 DOI: 10.1021/jm070332f  1
2008 Hruby VJ, Porreca F, Yamamura HI, Tollin G, Agnes RS, Lee YS, Cai M, Alves I, Cowell S, Varga E, Davis P, Salamon Z, Roeske W, Vanderah T, Lai J. New paradigms and tools in drug design for pain and addiction Drug Addiction: From Basic Research to Therapy. 477-494. DOI: 10.1007/978-0-387-76678-2_28  1
2007 King T, Vardanyan A, Majuta L, Melemedjian O, Nagle R, Cress AE, Vanderah TW, Lai J, Porreca F. Morphine treatment accelerates sarcoma-induced bone pain, bone loss, and spontaneous fracture in a murine model of bone cancer. Pain. 132: 154-68. PMID 17706870 DOI: 10.1016/j.pain.2007.06.026  1
2007 King SH, Mayorov AV, Balse-Srinivasan P, Hruby VJ, Vanderah TW, Wessells H. Melanocortin receptors, melanotropic peptides and penile erection. Current Topics in Medicinal Chemistry. 7: 1098-1106. PMID 17584130  1
2007 Yamamoto T, Nair P, Davis P, Ma SW, Navratilova E, Moye S, Tumati S, Lai J, Vanderah TW, Yamamura HI, Porreca F, Hruby VJ. Design, synthesis, and biological evaluation of novel bifunctional C-terminal-modified peptides for delta/mu opioid receptor agonists and neurokinin-1 receptor antagonists. Journal of Medicinal Chemistry. 50: 2779-86. PMID 17516639 DOI: 10.1021/jm061369n  1
2007 Vanderah TW. Pathophysiology of pain. The Medical Clinics of North America. 91: 1-12. PMID 17164100 DOI: 10.1016/j.mcna.2006.10.006  1
2007 Vera-Portocarrero LP, Zhang ET, King T, Ossipov MH, Vanderah TW, Lai J, Porreca F. Spinal NK-1 receptor expressing neurons mediate opioid-induced hyperalgesia and antinociceptive tolerance via activation of descending pathways. Pain. 129: 35-45. PMID 17123731 DOI: 10.1016/j.pain.2006.09.033  1
2006 Ndungu JM, Cain JP, Davis P, Ma SW, Vanderah TW, Lai J, Porreca F, Hruby VJ. Synthesis of constrained analogues of cholecystokinin/opioid chimeric peptides. Tetrahedron Letters. 47: 2233-2236. PMID 17203138 DOI: 10.1016/j.tetlet.2006.01.096  1
2006 Hruby VJ, Porreca F, Yamamura HI, Tollin G, Agnes RS, Lee YS, Cai M, Alves I, Cowell S, Varga E, Davis P, Salamon Z, Roeske W, Vanderah T, Lai J. New paradigms and tools in drug design for pain and addiction. The Aaps Journal. 8: E450-60. PMID 17025262 DOI: 10.1208/aapsj080353  1
2006 King T, Rao S, Vanderah T, Chen Q, Vardanyan A, Porreca F. Differential blockade of nerve injury-induced shift in weight bearing and thermal and tactile hypersensitivity by milnacipran. The Journal of Pain : Official Journal of the American Pain Society. 7: 513-20. PMID 16814690 DOI: 10.1016/j.jpain.2006.02.001  1
2006 Negus SS, Vanderah TW, Brandt MR, Bilsky EJ, Becerra L, Borsook D. Preclinical assessment of candidate analgesic drugs: recent advances and future challenges. The Journal of Pharmacology and Experimental Therapeutics. 319: 507-14. PMID 16751251 DOI: 10.1124/jpet.106.106377  1
2006 Yue X, Varga EV, Stropova D, Vanderah TW, Yamamura HI, Roeske WR. Chronic morphine-mediated adenylyl cyclase superactivation is attenuated by the Raf-1 inhibitor, GW5074. European Journal of Pharmacology. 540: 57-9. PMID 16750187 DOI: 10.1016/j.ejphar.2006.04.033  1
2006 Porreca F, Vanderah TW, Guo W, Barth M, Dodey P, Peyrou V, Luccarini JM, Junien JL, Pruneau D. Antinociceptive pharmacology of N-[[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]methyl]-2-[2-[[(4-methoxy-2,6-dimethylphenyl) sulfonyl]methylamino]ethoxy]-N-methylacetamide, fumarate (LF22-0542), a novel nonpeptidic bradykinin B1 receptor antagonist. The Journal of Pharmacology and Experimental Therapeutics. 318: 195-205. PMID 16565167 DOI: 10.1124/jpet.105.098368  1
2006 Ibrahim MM, Rude ML, Stagg NJ, Mata HP, Lai J, Vanderah TW, Porreca F, Buckley NE, Makriyannis A, Malan TP. CB2 cannabinoid receptor mediation of antinociception. Pain. 122: 36-42. PMID 16563625 DOI: 10.1016/j.pain.2005.12.018  1
2006 Gardell LR, King T, Ossipov MH, Rice KC, Lai J, Vanderah TW, Porreca F. Opioid receptor-mediated hyperalgesia and antinociceptive tolerance induced by sustained opiate delivery. Neuroscience Letters. 396: 44-9. PMID 16343768 DOI: 10.1016/j.neulet.2005.11.009  1
2005 King T, Ossipov MH, Vanderah TW, Porreca F, Lai J. Is paradoxical pain induced by sustained opioid exposure an underlying mechanism of opioid antinociceptive tolerance? Neuro-Signals. 14: 194-205. PMID 16215302 DOI: 10.1159/000087658  1
2005 Navratilova E, Eaton MC, Stropova D, Varga EV, Vanderah TW, Roeske WR, Yamamura HI. Morphine promotes phosphorylation of the human delta-opioid receptor at serine 363. European Journal of Pharmacology. 519: 212-4. PMID 16135360 DOI: 10.1016/j.ejphar.2005.07.024  1
2005 Wessells H, Blevins JE, Vanderah TW. Melanocortinergic control of penile erection. Peptides. 26: 1972-7. PMID 15992962 DOI: 10.1016/j.peptides.2004.11.035  1
2005 King T, Gardell LR, Wang R, Vardanyan A, Ossipov MH, Malan TP, Vanderah TW, Hunt SP, Hruby VJ, Lai J, Porreca F. Role of NK-1 neurotransmission in opioid-induced hyperalgesia. Pain. 116: 276-88. PMID 15964684 DOI: 10.1016/j.pain.2005.04.014  1
2005 Ossipov MH, Lai J, King T, Vanderah TW, Porreca F. Underlying mechanisms of pronociceptive consequences of prolonged morphine exposure. Biopolymers. 80: 319-24. PMID 15795927 DOI: 10.1002/bip.20254  1
2005 Ibrahim MM, Porreca F, Lai J, Albrecht PJ, Rice FL, Khodorova A, Davar G, Makriyannis A, Vanderah TW, Mata HP, Malan TP. CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids. Proceedings of the National Academy of Sciences of the United States of America. 102: 3093-8. PMID 15705714 DOI: 10.1073/pnas.0409888102  1
2005 Varga EV, Hosohata K, Borys D, Navratilova E, Nylen A, Vanderah TW, Porreca F, Roeske WR, Yamamura HI. Antinociception depends on the presence of G protein gamma2-subunits in brain. European Journal of Pharmacology. 508: 93-8. PMID 15680258 DOI: 10.1016/j.ejphar.2004.11.062  1
2005 Xie JY, Herman DS, Stiller CO, Gardell LR, Ossipov MH, Lai J, Porreca F, Vanderah TW. Cholecystokinin in the rostral ventromedial medulla mediates opioid-induced hyperalgesia and antinociceptive tolerance. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 409-16. PMID 15647484 DOI: 10.1523/JNEUROSCI.4054-04.2005  1
2005 Gavva NR, Tamir R, Qu Y, Klionsky L, Zhang TJ, Immke D, Wang J, Zhu D, Vanderah TW, Porreca F, Doherty EM, Norman MH, Wild KD, Bannon AW, Louis JC, et al. AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties. The Journal of Pharmacology and Experimental Therapeutics. 313: 474-84. PMID 15615864 DOI: 10.1124/jpet.104.079855  1
2004 Ossipov MH, Lai J, King T, Vanderah TW, Malan TP, Hruby VJ, Porreca F. Antinociceptive and nociceptive actions of opioids. Journal of Neurobiology. 61: 126-48. PMID 15362157 DOI: 10.1002/neu.20091  1
2004 Yezierski RP, Radson E, Vanderah TW. Understanding chronic pain. Nursing. 34: 22-3. PMID 15247653 DOI: 10.1097/00152193-200404000-00021  1
2004 Chen Q, King T, Vanderah TW, Ossipov MH, Malan TP, Lai J, Porreca F. Differential blockade of nerve injury-induced thermal and tactile hypersensitivity by systemically administered brain-penetrating and peripherally restricted local anesthetics. The Journal of Pain : Official Journal of the American Pain Society. 5: 281-9. PMID 15219260 DOI: 10.1016/j.jpain.2004.05.002  1
2004 Quartilho A, Mata HP, Ibrahim MM, Vanderah TW, Ossipov MH, Lai J, Porreca F, Malan TP. Production of paradoxical sensory hypersensitivity by alpha 2-adrenoreceptor agonists. Anesthesiology. 100: 1538-44. PMID 15166576 DOI: 10.1097/00000542-200406000-00029  1
2004 Gavva NR, Klionsky L, Qu Y, Shi L, Tamir R, Edenson S, Zhang TJ, Viswanadhan VN, Toth A, Pearce LV, Vanderah TW, Porreca F, Blumberg PM, Lile J, Sun Y, et al. Molecular determinants of vanilloid sensitivity in TRPV1. The Journal of Biological Chemistry. 279: 20283-95. PMID 14996838 DOI: 10.1074/jbc.M312577200  1
2004 Vanderah TW, Schteingart CD, Trojnar J, Junien JL, Lai J, Riviere PJ. FE200041 (D-Phe-D-Phe-D-Nle-D-Arg-NH2): A peripheral efficacious kappa opioid agonist with unprecedented selectivity. The Journal of Pharmacology and Experimental Therapeutics. 310: 326-33. PMID 14993260 DOI: 10.1124/jpet.104.065391  1
2003 Wang R, Guo W, Ossipov MH, Vanderah TW, Porreca F, Lai J. Glial cell line-derived neurotrophic factor normalizes neurochemical changes in injured dorsal root ganglion neurons and prevents the expression of experimental neuropathic pain. Neuroscience. 121: 815-24. PMID 14568039 DOI: 10.1016/j.neuroscience.2004.03.032  1
2003 Gardell LR, Wang R, Ehrenfels C, Ossipov MH, Rossomando AJ, Miller S, Buckley C, Cai AK, Tse A, Foley SF, Gong B, Walus L, Carmillo P, Worley D, Huang C, ... ... Vanderah TW, et al. Multiple actions of systemic artemin in experimental neuropathy. Nature Medicine. 9: 1383-9. PMID 14528299 DOI: 10.1038/nm944  1
2003 Quartilho A, Mata HP, Ibrahim MM, Vanderah TW, Porreca F, Makriyannis A, Malan TP. Inhibition of inflammatory hyperalgesia by activation of peripheral CB2 cannabinoid receptors. Anesthesiology. 99: 955-60. PMID 14508331 DOI: 10.1097/00000542-200310000-00031  1
2003 Gardell LR, Vanderah TW, Gardell SE, Wang R, Ossipov MH, Lai J, Porreca F. Enhanced evoked excitatory transmitter release in experimental neuropathy requires descending facilitation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 8370-9. PMID 12967999  1
2003 Ibrahim MM, Deng H, Zvonok A, Cockayne DA, Kwan J, Mata HP, Vanderah TW, Lai J, Porreca F, Makriyannis A, Malan TP. Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS. Proceedings of the National Academy of Sciences of the United States of America. 100: 10529-33. PMID 12917492 DOI: 10.1073/pnas.1834309100  1
2003 Wessells H, Hruby VJ, Hackett J, Han G, Balse-Srinivasan P, Vanderah TW. MT-II induces penile erection via brain and spinal mechanisms. Annals of the New York Academy of Sciences. 994: 90-5. PMID 12851302  1
2003 Ossipov MH, Lai J, Vanderah TW, Porreca F. Induction of pain facilitation by sustained opioid exposure: relationship to opioid antinociceptive tolerance. Life Sciences. 73: 783-800. PMID 12801599 DOI: 10.1016/S0024-3205(03)00410-7  1
2003 Hruby VJ, Agnes RS, Davis P, Ma SW, Lee YS, Vanderah TW, Lai J, Porreca F. Design of novel peptide ligands which have opioid agonist activity and CCK antagonist activity for the treatment of pain. Life Sciences. 73: 699-704. PMID 12801591 DOI: 10.1016/S0024-3205(03)00390-4  1
2003 Wessells H, Hruby VJ, Hackett J, Han G, Balse-Srinivasan P, Vanderah TW. Ac-Nle-c[Asp-His-DPhe-Arg-Trp-Lys]-NH2 induces penile erection via brain and spinal melanocortin receptors. Neuroscience. 118: 755-62. PMID 12710982 DOI: 10.1016/S0306-4522(02)00866-7  1
2003 Malan TP, Ibrahim MM, Lai J, Vanderah TW, Makriyannis A, Porreca F. CB2 cannabinoid receptor agonists: pain relief without psychoactive effects? Current Opinion in Pharmacology. 3: 62-7. PMID 12550743 DOI: 10.1016/S1471-4892(02)00004-8  1
2003 Hosohata K, Varga EV, Alfaro-Lopez J, Tang X, Vanderah TW, Porreca F, Hruby VJ, Roeske WR, Yamamura HI. (2S,3R) beta-methyl-2',6'-dimethyltyrosine-L-tetrahydroisoquinoline-3-carboxylic acid [(2S,3R)TMT-L-Tic-OH] is a potent, selective delta-opioid receptor antagonist in mouse brain. The Journal of Pharmacology and Experimental Therapeutics. 304: 683-8. PMID 12538822 DOI: 10.1124/jpet.102.042929  1
2002 Malan TP, Ibrahim MM, Vanderah TW, Makriyannis A, Porreca F. Inhibition of pain responses by activation of CB(2) cannabinoid receptors. Chemistry and Physics of Lipids. 121: 191-200. PMID 12505700 DOI: 10.1016/S0009-3084(02)00155-X  1
2002 Gardell LR, Ossipov MH, Vanderah TW, Lai J, Porreca F. Dynorphin-independent spinal cannabinoid antinociception. Pain. 100: 243-8. PMID 12467995 DOI: 10.1016/S0304-3959(02)00173-2  1
2002 Gardell LR, Wang R, Burgess SE, Ossipov MH, Vanderah TW, Malan TP, Lai J, Porreca F. Sustained morphine exposure induces a spinal dynorphin-dependent enhancement of excitatory transmitter release from primary afferent fibers. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 6747-55. PMID 12151554  1
2002 Burgess SE, Gardell LR, Ossipov MH, Malan TP, Vanderah TW, Lai J, Porreca F. Time-dependent descending facilitation from the rostral ventromedial medulla maintains, but does not initiate, neuropathic pain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 5129-36. PMID 12077208  1
2001 Lai J, Ossipov MH, Vanderah TW, Malan TP, Porreca F. Neuropathic pain: the paradox of dynorphin. Molecular Interventions. 1: 160-7. PMID 14993349  1
2001 Rasband MN, Park EW, Vanderah TW, Lai J, Porreca F, Trimmer JS. Distinct potassium channels on pain-sensing neurons. Proceedings of the National Academy of Sciences of the United States of America. 98: 13373-8. PMID 11698689 DOI: 10.1073/pnas.231376298  1
2001 Porreca F, Burgess SE, Gardell LR, Vanderah TW, Malan TP, Ossipov MH, Lappi DA, Lai J. Inhibition of neuropathic pain by selective ablation of brainstem medullary cells expressing the mu-opioid receptor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 5281-8. PMID 11438603  1
2001 Simoneau II, Hamza MS, Mata HP, Siegel EM, Vanderah TW, Porreca F, Makriyannis A, Malan TP. The cannabinoid agonist WIN55,212-2 suppresses opioid-induced emesis in ferrets. Anesthesiology. 94: 882-7. PMID 11388542  1
2001 Vanderah TW, Ossipov MH, Lai J, Malan TP, Porreca F. Mechanisms of opioid-induced pain and antinociceptive tolerance: descending facilitation and spinal dynorphin. Pain. 92: 5-9. PMID 11323121 DOI: 10.1016/S0304-3959(01)00311-6  1
2001 Wang Z, Gardell LR, Ossipov MH, Vanderah TW, Brennan MB, Hochgeschwender U, Hruby VJ, Malan TP, Lai J, Porreca F. Pronociceptive actions of dynorphin maintain chronic neuropathic pain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 1779-86. PMID 11222667  1
2001 Vanderah TW, Suenaga NM, Ossipov MH, Malan TP, Lai J, Porreca F. Tonic descending facilitation from the rostral ventromedial medulla mediates opioid-induced abnormal pain and antinociceptive tolerance. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 279-86. PMID 11150345  1
2000 Vanderah TW, Gardell LR, Burgess SE, Ibrahim M, Dogrul A, Zhong CM, Zhang ET, Malan TP, Ossipov MH, Lai J, Porreca F. Dynorphin promotes abnormal pain and spinal opioid antinociceptive tolerance. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 7074-9. PMID 10995854  1
2000 Hosohata K, Logan JK, Varga E, Burkey TH, Vanderah TW, Porreca F, Hruby VJ, Roeske WR, Yamamura HI. The role of the G protein gamma(2) subunit in opioid antinociception in mice. European Journal of Pharmacology. 392: R9-R11. PMID 10762674 DOI: 10.1016/S0014-2999(00)00132-1  1
2000 Hosohata Y, Vanderah TW, Burkey TH, Ossipov MH, Kovelowski CJ, Sora I, Uhl GR, Zhang X, Rice KC, Roeske WR, Hruby VJ, Yamamura HI, Lai J, Porreca F. delta-Opioid receptor agonists produce antinociception and [35S]GTPgammaS binding in mu receptor knockout mice. European Journal of Pharmacology. 388: 241-8. PMID 10675732 DOI: 10.1016/S0014-2999(99)00897-3  1
1998 Vanderah TW, Raffa RB, Lashbrook J, Burritt A, Hruby V, Porreca F. Orphanin-FQ/nociceptin: lack of anti nociceptive, hyperalgesic or allodynic effects in acute thermal or mechanical tests following intracerebroventricular or intrathecal administration to mice or rats. European Journal of Pain (London, England). 2: 267-78. PMID 15102387  1
1998 Vanderah TW, Raffa RB, Lashbrook J, Burritt A, Hruby V, Porreca F. Orphanin-fq/nociceptin: Lack of antinociceptive, hyperalgesic or allodynic effects in acute thermal or mechanical tests following intracerebroventricular or intrathecal administration to mice or rats European Journal of Pain. 2: 267-280. DOI: 10.1016/S1090-3801(98)90023-4  1
1997 Minami K, Vanderah TW, Minami M, Harris RA. Inhibitory effects of anesthetics and ethanol on muscarinic receptors expressed in Xenopus oocytes. European Journal of Pharmacology. 339: 237-44. PMID 9473141 DOI: 10.1016/S0014-2999(97)01354-X  1
1997 Laughlin TM, Vanderah TW, Lashbrook J, Nichols ML, Ossipov M, Porreca F, Wilcox GL. Spinally administered dynorphin A produces long-lasting allodynia: involvement of NMDA but not opioid receptors. Pain. 72: 253-60. PMID 9272810 DOI: 10.1016/S0304-3959(97)00046-8  1
1997 Wegert S, Ossipov MH, Nichols ML, Bian D, Vanderah TW, Malan TP, Porreca F. Differential activities of intrathecal MK-801 or morphine to alter responses to thermal and mechanical stimuli in normal or nerve-injured rats. Pain. 71: 57-64. PMID 9200174 DOI: 10.1016/S0304-3959(97)03337-X  1
1996 Vanderah TW, Laughlin T, Lashbrook JM, Nichols ML, Wilcox GL, Ossipov MH, Malan TP, Porreca F. Single intrathecal injections of dynorphin A or des-Tyr-dynorphins produce long-lasting allodynia in rats: blockade by MK-801 but not naloxone. Pain. 68: 275-81. PMID 9121815 DOI: 10.1016/S0304-3959(96)03225-3  1
1996 Vanderah TW, Bernstein RN, Yamamura HI, Hruby VJ, Porreca F. Enhancement of morphine antinociception by a CCKB antagonist in mice is mediated via opioid delta receptors. The Journal of Pharmacology and Experimental Therapeutics. 278: 212-9. PMID 8764354  1
1996 Edsall SA, Knapp RJ, Vanderah TW, Roeske WR, Consroe P, Yamamura HI. Antisense oligodeoxynucleotide treatment to the brain cannabinoid receptor inhibits antinociception. Neuroreport. 7: 593-6. PMID 8730837  1
1996 Zaki PA, Bilsky EJ, Vanderah TW, Lai J, Evans CJ, Porreca F. Opioid receptor types and subtypes: the delta receptor as a model. Annual Review of Pharmacology and Toxicology. 36: 379-401. PMID 8725395 DOI: 10.1146/annurev.pa.36.040196.002115  1
1994 Vanderah TW, Lai J, Yamamura HI, Porreca F. Antisense oligodeoxynucleotide to the CCKB receptor produces naltrindole- and [Leu5]enkephalin antiserum-sensitive enhancement of morphine antinociception. Neuroreport. 5: 2601-5. PMID 7696612  1
1993 Vanderah TW, Wild KD, Takemori AE, Sultana M, Portoghese PS, Bowen WD, Hruby VJ, Mosberg HI, Porreca F. Modulation of morphine antinociception by swim-stress in the mouse: involvement of supraspinal opioid delta-2 receptors. The Journal of Pharmacology and Experimental Therapeutics. 267: 449-55. PMID 8229774  1
1992 Vanderah TW, Wild KD, Takemori AE, Sultana M, Portoghese PS, Bowen WD, Mosberg HI, Porreca F. Mediation of swim-stress antinociception by the opioid delta 2 receptor in the mouse. The Journal of Pharmacology and Experimental Therapeutics. 262: 190-7. PMID 1320682  1
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