Frank Porreca - Publications

Affiliations: 
University of Arizona, Tucson, AZ 
Area:
pain, opioids, pharmacology

214 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Diener HC, Dodick D, Evers S, Holle D, Jensen RH, Lipton RB, Porreca F, Silberstein S, Schwedt T. Pathophysiology, prevention, and treatment of medication overuse headache. The Lancet. Neurology. PMID 31174999 DOI: 10.1016/S1474-4422(19)30146-2  0.4
2019 Khanna R, Patwardhan A, Yang X, Li W, Cai S, Ji Y, Chew LA, Dorame A, Bellampalli SS, Schmoll RW, Gordon J, Moutal A, Vanderah TW, Porreca F, Ibrahim MM. Development and Characterization of An Injury-free Model of Functional Pain in Rats by Exposure to Red Light. The Journal of Pain : Official Journal of the American Pain Society. PMID 31054915 DOI: 10.1016/j.jpain.2019.04.008  1
2019 Navratilova E, Patwardhan A, Porreca F. Opioid analgesics pass the acid test. Lancet (London, England). 393: 1579-1581. PMID 31007186 DOI: 10.1016/S0140-6736(19)30421-0  0.76
2019 Xie JY, Qu C, Munro G, Petersen KA, Porreca F. Antihyperalgesic effects of Meteorin in the rat chronic constriction injury (CCI) model: a replication study. Pain. PMID 30908357 DOI: 10.1097/j.pain.0000000000001569  0.72
2019 Phelps CE, Navratilova E, Dickenson AH, Porreca F, Bannister K. Kappa Opioid Signaling in the Right Central Amygdala Causes Hindpaw Specific Loss of Diffuse Noxious Inhibitory Controls (DNIC) in Experimental Neuropathic Pain. Pain. PMID 30870321 DOI: 10.1097/j.pain.0000000000001553  0.76
2019 Navratilova E, Porreca F. Substance P and Inflammatory Pain: Getting It Wrong and Right Simultaneously. Neuron. 101: 353-355. PMID 30731054 DOI: 10.1016/j.neuron.2019.01.034  0.76
2018 Navratilova E, Ji G, Phelps C, Qu C, Hein M, Yakhnitsa V, Neugebauer V, Porreca F. Kappa opioid signaling in the central nucleus of the amygdala promotes disinhibition and aversiveness of chronic neuropathic pain. Pain. PMID 30681985 DOI: 10.1097/j.pain.0000000000001458  0.76
2018 Nation KM, Dodick DW, Navratilova E, Porreca F. Sustained exposure to acute migraine medications combined with repeated noxious stimulation dysregulates descending pain modulatory circuits: Relevance to medication overuse headache. Cephalalgia : An International Journal of Headache. 333102418804157. PMID 30286616 DOI: 10.1177/0333102418804157  0.76
2018 Snyder LM, Chiang MC, Loeza-Alcocer E, Omori Y, Hachisuka J, Sheahan TD, Gale JR, Adelman PC, Sypek EI, Fulton SA, Friedman RL, Wright MC, Duque MG, Lee YS, Hu Z, ... ... Porreca F, et al. Kappa Opioid Receptor Distribution and Function in Primary Afferents. Neuron. 99: 1274-1288.e6. PMID 30236284 DOI: 10.1016/j.neuron.2018.08.044  0.64
2018 Johnstone TBC, Xie JY, Qu C, Wasiak DJ, Hogenkamp DJ, Porreca F, Gee KW. Positive Allosteric Modulators of Non-Benzodiazepine γ-Aminobutyric acida Receptor Subtypes for the Treatment of Chronic Pain. Pain. PMID 30204648 DOI: 10.1097/j.pain.0000000000001392  0.72
2018 Schiene K, Schröder W, Linz K, Frosch S, Tzschentke TM, Christoph T, Xie JY, Porreca F. Inhibition of experimental visceral pain in rodents by cebranopadol. Behavioural Pharmacology. PMID 30161034 DOI: 10.1097/FBP.0000000000000420  0.72
2018 Gomtsian L, Bannister K, Eyde N, Robles D, Dickenson AH, Porreca F, Navratilova E. Morphine effects within the rodent anterior cingulate cortex and rostral ventromedial medulla reveal separable modulation of affective and sensory qualities of acute or chronic pain. Pain. PMID 30086115 DOI: 10.1097/j.pain.0000000000001355  0.76
2018 Garami A, Ibrahim M, Gilbraith K, Khanna R, Pakai E, Miko A, Pinter E, Romanovsky AA, Porreca F, Patwardhan AM. In Reply. Anesthesiology. 129: 378-379. PMID 30020181 DOI: 10.1097/ALN.0000000000002294  0.6
2018 Patel R, Qu C, Xie JY, Porreca F, Dickenson AH. Selective deficiencies in descending inhibitory modulation in neuropathic rats: implications for enhancing noradrenergic tone. Pain. PMID 29863529 DOI: 10.1097/j.pain.0000000000001300  0.72
2018 Remesic M, Macedonio G, Mollica A, Porreca F, Hruby V, Lee YS. Cyclic biphalin analogues with a novel linker lead to potent agonist activities at mu, delta, and kappa opioid receptors. Bioorganic & Medicinal Chemistry. PMID 29858157 DOI: 10.1016/j.bmc.2018.05.045  0.64
2018 Patwardhan A, Porreca F, Schmidt WK, Romanovsky AA. The opioid crisis and … reconsidering the use of drugs that affect body temperature. Temperature (Austin, Tex.). 5: 1-3. PMID 29687038 DOI: 10.1080/23328940.2018.1437312  0.36
2018 Cowen SL, Phelps CE, Navratilova E, McKinzie DL, Okun A, Husain O, Gleason SD, Witkin JM, Porreca F. Chronic pain impairs cognitive flexibility and engages novel learning strategies in rats. Pain. PMID 29578947 DOI: 10.1097/j.pain.0000000000001226  0.76
2018 Nation KM, DeFelice M, Hernandez PI, Dodick DW, Neugebauer V, Navratilova E, Porreca F. Lateralized Kappa Opioid Receptor Signaling from the Amygdala Central Nucleus Promotes Stress-Induced Functional Pain. Pain. PMID 29369967 DOI: 10.1097/j.pain.0000000000001167  0.76
2018 Watanabe M, Narita M, Hamada Y, Yamashita A, Tamura H, Ikegami D, Kondo T, Shinzato T, Shimizu T, Fukuchi Y, Muto A, Okano H, Yamanaka A, Tawfik V, Kuzumaki N, ... ... Porreca F, et al. [EXPRESS] Activation of ventral tegmental area dopaminergic neurons reverses pathological allodynia resulting from nerve injury or bone cancer. Molecular Pain. 1744806918756406. PMID 29357732 DOI: 10.1177/1744806918756406  0.76
2018 Watanabe M, Sugiura Y, Sugiyama E, Narita M, Navratilova E, Kondo T, Uchiyama N, Yamanaka A, Kuzumaki N, Porreca F, Narita M. [EXPRESS] Extracellular N-acetylaspartylglutamate released in the nucleus accumbens modulates the pain sensation: analysis using a microdialysis/mass spectrometry integrated system. Molecular Pain. 1744806918754934. PMID 29310499 DOI: 10.1177/1744806918754934  0.76
2017 Remeniuk B, King T, Suktankhar D, Nippert A, Li N, Li F, Cheng K, Rice KC, Porreca F. Disease modifying actions of IL-6 blockade in a rat model of bone cancer pain. Pain. PMID 29300279 DOI: 10.1097/j.pain.0000000000001139  0.72
2017 Godfrey L, Iannitelli A, Garrett NL, Moger J, Imbert I, King T, Porreca F, Soundararajan R, Lalatsa A, Schätzlein AG, Uchegbu IF. Nanoparticulate peptide delivery exclusively to the brain produces tolerance free analgesia. Journal of Controlled Release : Official Journal of the Controlled Release Society. 270: 135-144. PMID 29191784 DOI: 10.1016/j.jconrel.2017.11.041  0.72
2017 Bannister K, Qu C, Navratilova E, Oyarzo J, Xie JY, King T, Dickenson AH, Porreca F. Multiple sites and actions of gabapentin-induced relief of ongoing experimental neuropathic pain. Pain. PMID 28832395 DOI: 10.1097/j.pain.0000000000001040  0.76
2017 Vardanyan RS, Cain JP, Haghighi SM, Kumirov VK, McIntosh MI, Sandweiss AJ, Porreca F, Hruby VJ. Synthesis and Investigation of Mixed μ-Opioid and δ-Opioid Agonists as Possible Bivalent Ligands for Treatment of Pain. Journal of Heterocyclic Chemistry. 54: 1228-1235. PMID 28819330 DOI: 10.1002/jhet.2696  0.88
2017 Moutal A, Yang X, Li W, Gilbraith KB, Luo S, Cai S, François-Moutal L, Chew LA, Yeon SK, Bellampalli SS, Qu C, Xie JY, Ibrahim MM, Khanna M, Park KD, ... Porreca F, et al. CRISPR/Cas9 editing of Nf1 gene identifies CRMP2 as a therapeutic target in neurofibromatosis type 1-related pain that is reversed by (S)-Lacosamide. Pain. PMID 28809766 DOI: 10.1097/j.pain.0000000000001002  0.72
2017 Garami A, Ibrahim M, Gilbraith K, Khanna R, Pakai E, Miko A, Pinter E, Romanovsky AA, Porreca F, Patwardhan AM. Transient Receptor Potential Vanilloid 1 Antagonists Prevent Anesthesia-induced Hypothermia and Decrease Postincisional Opioid Dose Requirements in Rodents. Anesthesiology. PMID 28806222 DOI: 10.1097/ALN.0000000000001812  0.6
2017 Chichorro JG, Porreca F, Sessle B. Mechanisms of craniofacial pain. Cephalalgia : An International Journal of Headache. 333102417704187. PMID 28440673 DOI: 10.1177/0333102417704187  0.4
2017 Havelin J, Imbert I, Sukhtankar D, Remeniuk B, Pelletier I, Gentry J, Okun A, Tiutan T, Porreca F, King T. Mediation of movement-induced breakthrough cancer pain by IB4 binding nociceptors in rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28438966 DOI: 10.1523/JNEUROSCI.1212-16.2017  0.72
2017 Xie JY, De Felice M, Kopruszinski CM, Eyde N, LaVigne J, Remeniuk B, Hernandez P, Yue X, Goshima N, Ossipov M, King T, Streicher JM, Navratilova E, Dodick D, Rosen H, ... ... Porreca F, et al. Kappa opioid receptor antagonists: A possible new class of therapeutics for migraine prevention. Cephalalgia : An International Journal of Headache. 333102417702120. PMID 28376659 DOI: 10.1177/0333102417702120  0.76
2017 Remesic MV, Hruby VJ, Porreca F, Lee YS. Recent Advances in the Realm of Allosteric Modulators for the Opioid Receptors for Future Therapeutics. Acs Chemical Neuroscience. PMID 28368571 DOI: 10.1021/acschemneuro.7b00090  0.88
2017 Porreca F, Navratilova E. Reward, motivation and emotion of pain and its relief. Pain. PMID 28106670 DOI: 10.1097/j.pain.0000000000000798  0.76
2017 Ibrahim MM, Patwardhan A, Gilbraith KB, Moutal A, Yang X, Chew LA, Largent-Milnes T, Malan TP, Vanderah TW, Porreca F, Khanna R. Long-lasting antinociceptive effects of green light in acute and chronic pain in rats. Pain. 158: 347-360. PMID 28092651 DOI: 10.1097/j.pain.0000000000000767  1
2016 Moutal A, Eyde N, Telemi E, Park KD, Xie JY, Dodick DW, Porreca F, Khanna R. Efficacy of (S)-Lacosamide in preclinical models of cephalic pain. Pain Reports (Baltimore, Md.). 1. PMID 27917413 DOI: 10.1097/PR9.0000000000000565  0.72
2016 Rice FL, Xie JY, Albrecht PJ, Acker E, Bourgeois J, Navratilova E, Dodick DW, Porreca F. Anatomy and immunochemical characterization of the non-arterial peptidergic diffuse dural innervation of the rat and Rhesus monkey: Implications for functional regulation and treatment in migraine. Cephalalgia : An International Journal of Headache. PMID 27852962 DOI: 10.1177/0333102416677051  0.76
2016 Ramos-Colon CN, Lee YS, Remesic MV, Hall SM, LaVigne J, Davis P, Sandweiss AJ, McIntosh MI, Hanson J, Largent-Milnes TM, Vanderah TW, Streicher JM, Porreca F, Hruby VJ. Structure Activity Relationships of [des-Arg(7)]- Dynorphin A Analogues at the Kappa Opioid Receptor. Journal of Medicinal Chemistry. PMID 27797517 DOI: 10.1021/acs.jmedchem.6b01411  1
2016 Lee YS, Remesic M, Ramos-Colon C, Hall SM, Kuzmin A, Rankin D, Porreca F, Lai J, Hruby VJ. Cyclic non-opioid dynorphin A analogues for the bradykinin receptors. Bioorganic & Medicinal Chemistry Letters. PMID 27756562 DOI: 10.1016/j.bmcl.2016.10.010  0.88
2016 Hall SM, LeBaron L, Ramos-Colon CN, Qu C, Xie JY, Porreca F, Lai J, Lee YS, Hruby VJ. Discovery of Stable Non-opioid Dynorphin A Analogues Interacting at the Bradykinin Receptors for the Treatment of Neuropathic Pain. Acs Chemical Neuroscience. PMID 27619237 DOI: 10.1021/acschemneuro.6b00258  0.88
2016 Okun A, McKinzie DL, Witkin JM, Remeniuk B, Husein O, Gleason SD, Oyarzo J, Navratilova E, McElroy B, Cowen S, Kennedy JD, Porreca F. Hedonic and motivational responses to food reward are unchanged in rats with neuropathic pain. Pain. PMID 27548047 DOI: 10.1097/j.pain.0000000000000695  0.76
2016 Xie JY, Chew LA, Yang X, Wang Y, Qu C, Wang Y, Federici LM, Fitz SD, Ripsch MS, Due MR, Moutal A, Khanna M, White FA, Vanderah TW, Johnson PL, ... Porreca F, et al. Sustained relief of ongoing experimental neuropathic pain by a CRMP2 peptide aptamer with low abuse potential. Pain. 157: 2124-2140. PMID 27537210 DOI: 10.1097/j.pain.0000000000000628  1
2016 Kopruszinski CM, Xie JY, Eyde NM, Remeniuk B, Walter S, Stratton J, Bigal M, Chichorro JG, Dodick D, Porreca F. Prevention of stress- or nitric oxide donor-induced medication overuse headache by a calcitonin gene-related peptide antibody in rodents. Cephalalgia : An International Journal of Headache. PMID 27206958 DOI: 10.1177/0333102416650702  0.72
2016 Lee YS, Kupp R, Remesic M, Ramos-Colon C, Hall SM, Chan C, Rankin D, Lai J, Porreca F, Hruby VJ. Various modifications of the amphipathic dynorphin A phamacophore for rat brain bradykinin receptors. Chemical Biology & Drug Design. PMID 27203574 DOI: 10.1111/cbdd.12789  1
2016 Moutal A, Chew LA, Yang X, Wang Y, Yeon SK, Telemi E, Meroueh S, Park KD, Shrinivasan R, Gilbraith KB, Qu C, Xie JY, Patwardhan A, Vanderah TW, Khanna M, ... Porreca F, et al. (S)-Lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology. Pain. PMID 26967696 DOI: 10.1097/j.pain.0000000000000555  1
2016 Navratilova E, Morimura K, Xie JY, Atcherley CW, Ossipov MH, Porreca F. Positive emotions and brain reward circuits in chronic pain. The Journal of Comparative Neurology. PMID 26788716 DOI: 10.1002/cne.23968  1
2015 Havelin J, Imbert I, Cormier J, Allen J, Porreca F, King T. Central sensitization and neuropathic features of ongoing pain in a rat model of advanced osteoarthritis. The Journal of Pain : Official Journal of the American Pain Society. PMID 26694132 DOI: 10.1016/j.jpain.2015.12.001  1
2015 Andrews NA, Latrémolière A, Basbaum AI, Mogil JS, Porreca F, Rice AS, Woolf CJ, Currie GL, Dworkin RH, Eisenach JC, Evans S, Gewandter JS, Gover TD, Handwerker H, Huang W, et al. Ensuring transparency and minimization of methodologic bias in preclinical pain research: Pprecise considerations. Pain. PMID 26683237 DOI: 10.1097/j.pain.0000000000000458  1
2015 Navratilova E, Atcherley CW, Porreca F. Brain Circuits Encoding Reward from Pain Relief. Trends in Neurosciences. PMID 26603560 DOI: 10.1016/j.tins.2015.09.003  1
2015 Giri AK, Apostol CR, Wang Y, Forte BL, Largent-Milnes TM, Davis P, Rankin D, Molnar G, Olson KM, Porreca F, Vanderah TW, Hruby VJ. Discovery of Novel Multifunctional Ligands with μ/δ Opioid Agonist/Neurokinin-1 (NK1) Antagonist Activities for the Treatment of Pain. Journal of Medicinal Chemistry. PMID 26465170 DOI: 10.1021/acs.jmedchem.5b01170  1
2015 Harasawa I, Johansen JP, Fields HL, Porreca F, Meng ID. Alterations in the rostral ventromedial medulla after the selective ablation of mu-opioid receptor expressing neurons. Pain. PMID 26335909 DOI: 10.1097/j.pain.0000000000000344  0.44
2015 Deekonda S, Wugalter L, Rankin D, Largent-Milnes TM, Davis P, Wang Y, Bassirirad NM, Lai J, Kulkarni V, Vanderah TW, Porreca F, Hruby VJ. Design and synthesis of novel bivalent ligands (MOR and DOR) by conjugation of enkephalin analogues with 4-anilidopiperidine derivatives. Bioorganic & Medicinal Chemistry Letters. PMID 26323872 DOI: 10.1016/j.bmcl.2015.07.064  1
2015 Deekonda S, Rankin D, Davis P, Lai J, Porreca F, Hruby VJ. Design, synthesis and biological evaluation of multifunctional ligands targeting opioid and bradykinin 2 receptors. Bioorganic & Medicinal Chemistry Letters. 25: 4148-52. PMID 26316468 DOI: 10.1016/j.bmcl.2015.08.014  0.88
2015 Deekonda S, Wugalter L, Kulkarni V, Rankin D, Largent-Milnes TM, Davis P, Bassirirad NM, Lai J, Vanderah TW, Porreca F, Hruby VJ. Discovery of 5-substituted tetrahydronaphthalen-2yl-methyl with N-phenyl-N-(piperidin-4-yl)propionamide derivatives as potent opioid receptor ligands. Bioorganic & Medicinal Chemistry. 23: 6185-94. PMID 26299827 DOI: 10.1016/j.bmc.2015.07.071  1
2015 Lee YS, Hall SM, Ramos-Colon C, Remesic M, Rankin D, Vanderah TW, Porreca F, Lai J, Hruby VJ. Blockade of non-opioid excitatory effects of spinal dynorphin A at bradykinin receptors. Receptors & Clinical Investigation. 2. PMID 26221618 DOI: 10.14800/rci.517  1
2015 Nair P, Yamamoto T, Cowell S, Kulkarni V, Moye S, Navratilova E, Davis P, Ma SW, Vanderah TW, Lai J, Porreca F, Hruby VJ. Discovery of tripeptide-derived multifunctional ligands possessing delta/mu opioid receptor agonist and neurokinin 1 receptor antagonist activities. Bioorganic & Medicinal Chemistry Letters. 25: 3716-20. PMID 26212775 DOI: 10.1016/j.bmcl.2015.06.030  1
2015 Remeniuk B, Sukhtankar D, Okun A, Navratilova E, Xie JY, King T, Porreca F. Behavioral and Neurochemical Analysis of Ongoing Bone Cancer Pain in Rats. Pain. PMID 25955964 DOI: 10.1097/j.pain.0000000000000218  1
2015 Navratilova E, Xie JY, Meske D, Qu C, Morimura K, Okun A, Arakawa N, Ossipov M, Fields HL, Porreca F. Endogenous opioid activity in the anterior cingulate cortex is required for relief of pain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 7264-71. PMID 25948274 DOI: 10.1523/JNEUROSCI.3862-14.2015  1
2015 Vreeland RF, Atcherley CW, Russell WS, Xie JY, Lu D, Laude ND, Porreca F, Heien ML. Biocompatible PEDOT:Nafion composite electrode coatings for selective detection of neurotransmitters in vivo. Analytical Chemistry. 87: 2600-7. PMID 25692657 DOI: 10.1021/ac502165f  1
2015 Guillemyn K, Kleczkowska P, Lesniak A, Dyniewicz J, Van der Poorten O, Van den Eynde I, Keresztes A, Varga E, Lai J, Porreca F, Chung NN, Lemieux C, Mika J, Rojewska E, Makuch W, et al. Synthesis and biological evaluation of compact, conformationally constrained bifunctional opioid agonist - neurokinin-1 antagonist peptidomimetics. European Journal of Medicinal Chemistry. 92: 64-77. PMID 25544687 DOI: 10.1016/j.ejmech.2014.12.033  1
2015 Lee YS, Hall SM, Ramos-Colon C, Remesic M, LeBaron L, Nguyen A, Rankin D, Porreca F, Lai J, Hruby VJ. Modification of amphipathic non-opioid dynorphin A analogues for rat brain bradykinin receptors. Bioorganic & Medicinal Chemistry Letters. 25: 30-3. PMID 25434001 DOI: 10.1016/j.bmcl.2014.11.026  1
2015 Little JW, Ford A, Symons-Liguori AM, Chen Z, Janes K, Doyle T, Xie J, Luongo L, Tosh DK, Maione S, Bannister K, Dickenson AH, Vanderah TW, Porreca F, Jacobson KA, et al. Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states. Brain : a Journal of Neurology. 138: 28-35. PMID 25414036 DOI: 10.1093/brain/awu330  1
2014 Lee YS, Rankin D, Hall SM, Ramos-Colon C, Ortiz JJ, Kupp R, Porreca F, Lai J, Hruby VJ. Structure-activity relationships of non-opioid [des-Arg(7)]-dynorphin A analogues for bradykinin receptors. Bioorganic & Medicinal Chemistry Letters. 24: 4976-9. PMID 25282551 DOI: 10.1016/j.bmcl.2014.09.033  1
2014 Navratilova E, Porreca F. Reward and motivation in pain and pain relief. Nature Neuroscience. 17: 1304-12. PMID 25254980 DOI: 10.1038/nn.3811  1
2014 Mollica A, Carotenuto A, Novellino E, Limatola A, Costante R, Pinnen F, Stefanucci A, Pieretti S, Borsodi A, Samavati R, Zador F, Benyhe S, Davis P, Porreca F, Hruby VJ. Novel cyclic biphalin analogue with improved antinociceptive properties. Acs Medicinal Chemistry Letters. 5: 1032-6. PMID 25221662 DOI: 10.1021/ml500241n  1
2014 Dussor G, Yan J, Xie JY, Ossipov MH, Dodick DW, Porreca F. Targeting TRP channels for novel migraine therapeutics. Acs Chemical Neuroscience. 5: 1085-96. PMID 25138211 DOI: 10.1021/cn500083e  1
2014 Borsook D, Hargreaves R, Bountra C, Porreca F. Lost but making progress--Where will new analgesic drugs come from? Science Translational Medicine. 6: 249sr3. PMID 25122640 DOI: 10.1126/scitranslmed.3008320  1
2014 King T, Porreca F. Preclinical assessment of pain: improving models in discovery research. Current Topics in Behavioral Neurosciences. 20: 101-20. PMID 25012511 DOI: 10.1007/7854_2014_330  1
2014 Bannister K, Lee YS, Goncalves L, Porreca F, Lai J, Dickenson AH. Neuropathic plasticity in the opioid and non-opioid actions of dynorphin A fragments and their interactions with bradykinin B2 receptors on neuronal activity in the rat spinal cord. Neuropharmacology. 85: 375-83. PMID 24937046 DOI: 10.1016/j.neuropharm.2014.06.005  1
2014 Xie JY, Qu C, Patwardhan A, Ossipov MH, Navratilova E, Becerra L, Borsook D, Porreca F. Activation of mesocorticolimbic reward circuits for assessment of relief of ongoing pain: a potential biomarker of efficacy. Pain. 155: 1659-66. PMID 24861580 DOI: 10.1016/j.pain.2014.05.018  1
2014 Ossipov MH, Morimura K, Porreca F. Descending pain modulation and chronification of pain. Current Opinion in Supportive and Palliative Care. 8: 143-51. PMID 24752199 DOI: 10.1097/SPC.0000000000000055  1
2014 Lee YS, Muthu D, Hall SM, Ramos-Colon C, Rankin D, Hu J, Sandweiss AJ, De Felice M, Xie JY, Vanderah TW, Porreca F, Lai J, Hruby VJ. Discovery of amphipathic dynorphin A analogues to inhibit the neuroexcitatory effects of dynorphin A through bradykinin receptors in the spinal cord. Journal of the American Chemical Society. 136: 6608-16. PMID 24742335 DOI: 10.1021/ja501677q  1
2014 Wang R, Rossomando A, Sah DW, Ossipov MH, King T, Porreca F. Artemin induced functional recovery and reinnervation after partial nerve injury. Pain. 155: 476-84. PMID 24269493 DOI: 10.1016/j.pain.2013.11.007  1
2014 Mamet J, Klukinov M, Yaksh TL, Malkmus SA, Williams S, Harris S, Manning DC, Taylor BK, Donahue RR, Porreca F, Xie JY, Oyarzo J, Brennan TJ, Subieta A, Schmidt WK, et al. Single intrathecal administration of the transcription factor decoy AYX1 prevents acute and chronic pain after incisional, inflammatory, or neuropathic injury. Pain. 155: 322-33. PMID 24145208 DOI: 10.1016/j.pain.2013.10.015  1
2014 Yoshimura RF, Tran MB, Hogenkamp DJ, Johnstone TB, Xie JY, Porreca F, Gee KW. Limited central side effects of a β-subunit subtype-selective GABAA receptor allosteric modulator. Journal of Psychopharmacology (Oxford, England). 28: 472-8. PMID 24108410 DOI: 10.1177/0269881113507643  1
2014 Meske DS, Xie JY, Oyarzo J, Badghisi H, Ossipov MH, Porreca F. Opioid and noradrenergic contributions of tapentadol in experimental neuropathic pain. Neuroscience Letters. 562: 91-6. PMID 23969300 DOI: 10.1016/j.neulet.2013.08.017  1
2013 Lee YS, Qu HC, Davis P, Ma SW, Vardanyan R, Lai J, Porreca F, Hruby VJ. Chiral Effect of a Phe Residue in Position 3 of the Dmt(1)-L(or D)-Tic(2) Analogues on Opioid Functional Activities. Acs Medicinal Chemistry Letters. 4: 656-659. PMID 24648867 DOI: 10.1021/ml400115n  1
2013 Green AL, Gu P, De Felice M, Dodick D, Ossipov MH, Porreca F. Increased susceptibility to cortical spreading depression in an animal model of medication-overuse headache. Cephalalgia : An International Journal of Headache. 34: 594-604. PMID 24335852 DOI: 10.1177/0333102413515344  1
2013 Nair P, Yamamoto T, Largent-Milnes TM, Cowell S, Kulkarni V, Moye S, Navratilova E, Davis P, Ma SW, Vanderah TW, Lai J, Porreca F, Hruby VJ. Truncation of the peptide sequence in bifunctional ligands with mu and delta opioid receptor agonist and neurokinin 1 receptor antagonist activities. Bioorganic & Medicinal Chemistry Letters. 23: 4975-8. PMID 23899615 DOI: 10.1016/j.bmcl.2013.06.065  1
2013 De Felice M, Eyde N, Dodick D, Dussor GO, Ossipov MH, Fields HL, Porreca F. Capturing the aversive state of cephalic pain preclinically. Annals of Neurology. 74: 257-65. PMID 23686557 DOI: 10.1002/ana.23922  1
2013 Stahl SM, Porreca F, Taylor CP, Cheung R, Thorpe AJ, Clair A. The diverse therapeutic actions of pregabalin: is a single mechanism responsible for several pharmacological activities? Trends in Pharmacological Sciences. 34: 332-9. PMID 23642658 DOI: 10.1016/j.tips.2013.04.001  1
2013 Petrov RR, Lee YS, Vardanyan RS, Liu L, Ma SW, Davis P, Lai J, Porreca F, Vanderah TW, Hruby VJ. Effect of anchoring 4-anilidopiperidines to opioid peptides. Bioorganic & Medicinal Chemistry Letters. 23: 3434-7. PMID 23623418 DOI: 10.1016/j.bmcl.2013.03.065  1
2013 Wang R, King T, De Felice M, Guo W, Ossipov MH, Porreca F. Descending facilitation maintains long-term spontaneous neuropathic pain. The Journal of Pain : Official Journal of the American Pain Society. 14: 845-53. PMID 23602267 DOI: 10.1016/j.jpain.2013.02.011  1
2013 Mollica A, Pinnen F, Costante R, Locatelli M, Stefanucci A, Pieretti S, Davis P, Lai J, Rankin D, Porreca F, Hruby VJ. Biological active analogues of the opioid peptide biphalin: mixed α/β(3)-peptides. Journal of Medicinal Chemistry. 56: 3419-23. PMID 23547584 DOI: 10.1021/jm301456c  1
2013 Sui P, Watanabe H, Ossipov MH, Porreca F, Bakalkin G, Bergquist J, Artemenko K. Dimethyl-labeling-based protein quantification and pathway search: a novel method of spinal cord analysis applicable for neurological studies. Journal of Proteome Research. 12: 2245-52. PMID 23520997 DOI: 10.1021/pr4001064  1
2013 Navratilova E, Xie JY, King T, Porreca F. Evaluation of reward from pain relief. Annals of the New York Academy of Sciences. 1282: 1-11. PMID 23496247 DOI: 10.1111/nyas.12095  1
2013 Taylor R, Pergolizzi JV, Porreca F, Raffa RB. Opioid antagonists for pain. Expert Opinion On Investigational Drugs. 22: 517-25. PMID 23484859 DOI: 10.1517/13543784.2013.778973  1
2013 Lozano-Ondoua AN, Hanlon KE, Symons-Liguori AM, Largent-Milnes TM, Havelin JJ, Ferland HL, Chandramouli A, Owusu-Ankomah M, Nikolich-Zugich T, Bloom AP, Jimenez-Andrade JM, King T, Porreca F, Nelson MA, Mantyh PW, et al. Disease modification of breast cancer-induced bone remodeling by cannabinoid 2 receptor agonists. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 28: 92-107. PMID 22903605 DOI: 10.1002/jbmr.1732  1
2012 Navratilova E, Xie JY, Okun A, Qu C, Eyde N, Ci S, Ossipov MH, King T, Fields HL, Porreca F. Pain relief produces negative reinforcement through activation of mesolimbic reward-valuation circuitry. Proceedings of the National Academy of Sciences of the United States of America. 109: 20709-13. PMID 23184995 DOI: 10.1073/pnas.1214605109  1
2012 Porreca F. Holiday message from Life Sciences. Life Sciences. 91: 1139. PMID 23063667 DOI: 10.1016/j.lfs.2012.10.001  1
2012 Mollica A, Pinnen F, Stefanucci A, Mannina L, Sobolev AP, Lucente G, Davis P, Lai J, Ma SW, Porreca F, Hruby VJ. cis-4-amino-L-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues: part 2. Journal of Medicinal Chemistry. 55: 8477-82. PMID 22966938 DOI: 10.1021/jm300947s  1
2012 Little JW, Chen Z, Doyle T, Porreca F, Ghaffari M, Bryant L, Neumann WL, Salvemini D. Supraspinal peroxynitrite modulates pain signaling by suppressing the endogenous opioid pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 10797-808. PMID 22875915 DOI: 10.1523/JNEUROSCI.6345-11.2012  1
2012 Annedi SC, Maddaford SP, Ramnauth J, Renton P, Rybak T, Silverman S, Rakhit S, Mladenova G, Dove P, Andrews JS, Zhang D, Porreca F. Discovery of a potent, orally bioavailable and highly selective human neuronal nitric oxide synthase (nNOS) inhibitor, N-(1-(piperidin-4-yl)indolin-5-yl)thiophene-2-carboximidamide as a pre-clinical development candidate for the treatment of migraine. European Journal of Medicinal Chemistry. 55: 94-107. PMID 22840695 DOI: 10.1016/j.ejmech.2012.07.006  1
2012 Edelmayer RM, Le LN, Yan J, Wei X, Nassini R, Materazzi S, Preti D, Appendino G, Geppetti P, Dodick DW, Vanderah TW, Porreca F, Dussor G. Activation of TRPA1 on dural afferents: a potential mechanism of headache pain. Pain. 153: 1949-58. PMID 22809691 DOI: 10.1016/j.pain.2012.06.012  1
2012 De Felice M, Melchiorri P, Ossipov MH, Vanderah TW, Porreca F, Negri L. Mechanisms of Bv8-induced biphasic hyperalgesia: increased excitatory transmitter release and expression. Neuroscience Letters. 521: 40-5. PMID 22641053 DOI: 10.1016/j.neulet.2012.05.055  1
2012 He Y, Tian X, Hu X, Porreca F, Wang ZJ. Negative reinforcement reveals non-evoked ongoing pain in mice with tissue or nerve injury. The Journal of Pain : Official Journal of the American Pain Society. 13: 598-607. PMID 22609247 DOI: 10.1016/j.jpain.2012.03.011  1
2012 Pajouhesh H, Feng ZP, Zhang L, Pajouhesh H, Jiang X, Hendricson A, Dong H, Tringham E, Ding Y, Vanderah TW, Porreca F, Belardetti F, Zamponi GW, Mitscher LA, Snutch TP. Structure-activity relationships of trimethoxybenzyl piperazine N-type calcium channel inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 4153-8. PMID 22579422 DOI: 10.1016/j.bmcl.2012.04.054  1
2012 Hughes JP, Chessell I, Malamut R, Perkins M, Bačkonja M, Baron R, Farrar JT, Field MJ, Gereau RW, Gilron I, McMahon SB, Porreca F, Rappaport BA, Rice F, Richman LK, et al. Understanding chronic inflammatory and neuropathic pain. Annals of the New York Academy of Sciences. 1255: 30-44. PMID 22564068 DOI: 10.1111/j.1749-6632.2012.06561.x  1
2012 King T, Qu C, Okun A, Melemedjian OK, Mandell EK, Maskaykina IY, Navratilova E, Dussor GO, Ghosh S, Price TJ, Porreca F. Contribution of PKMζ-dependent and independent amplification to components of experimental neuropathic pain. Pain. 153: 1263-73. PMID 22482911 DOI: 10.1016/j.pain.2012.03.006  1
2012 Mladenova G, Annedi SC, Ramnauth J, Maddaford SP, Rakhit S, Andrews JS, Zhang D, Porreca F. First-in-class, dual-action, 3,5-disubstituted indole derivatives having human nitric oxide synthase (nNOS) and norepinephrine reuptake inhibitory (NERI) activity for the treatment of neuropathic pain. Journal of Medicinal Chemistry. 55: 3488-501. PMID 22420844 DOI: 10.1021/jm300138g  1
2012 Mollica A, Pinnen F, Stefanucci A, Feliciani F, Campestre C, Mannina L, Sobolev AP, Lucente G, Davis P, Lai J, Ma SW, Porreca F, Hruby VJ. The cis-4-amino-L-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues. Journal of Medicinal Chemistry. 55: 3027-35. PMID 22394120 DOI: 10.1021/jm201402v  1
2012 Okun A, Liu P, Davis P, Ren J, Remeniuk B, Brion T, Ossipov MH, Xie J, Dussor GO, King T, Porreca F. Afferent drive elicits ongoing pain in a model of advanced osteoarthritis. Pain. 153: 924-33. PMID 22387095 DOI: 10.1016/j.pain.2012.01.022  1
2012 Annedi SC, Ramnauth J, Cossette M, Maddaford SP, Dove P, Rakhit S, Andrews JS, Porreca F. Novel, druglike 1,7-disubstituted 2,3,4,5-tetrahydro-1H-benzo[b]azepine-based selective inhibitors of human neuronal nitric oxide synthase (nNOS). Bioorganic & Medicinal Chemistry Letters. 22: 2510-3. PMID 22370270 DOI: 10.1016/j.bmcl.2012.02.004  1
2012 Edelmayer RM, Ossipov MH, Porreca F. An experimental model of headache-related pain. Methods in Molecular Biology (Clifton, N.J.). 851: 109-20. PMID 22351085 DOI: 10.1007/978-1-61779-561-9_7  1
2012 Ramnauth J, Renton P, Dove P, Annedi SC, Speed J, Silverman S, Mladenova G, Maddaford SP, Zinghini S, Rakhit S, Andrews J, Lee DK, Zhang D, Porreca F. 1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors: lead optimization studies resulting in the identification of N-(1-(2-(methylamino)ethyl)-1,2,3,4-tetrahydroquinolin-6-yl)thiophene-2-carboximidamide as a preclinical development candidate. Journal of Medicinal Chemistry. 55: 2882-93. PMID 22335555 DOI: 10.1021/jm3000449  1
2012 Annedi SC, Maddaford SP, Ramnauth J, Renton P, Speed J, Rakhit S, Andrews JS, Porreca F. 3,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase (nNOS) inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 1980-4. PMID 22318159 DOI: 10.1016/j.bmcl.2012.01.031  1
2012 Amrutkar DV, Ploug KB, Hay-Schmidt A, Porreca F, Olesen J, Jansen-Olesen I. mRNA expression of 5-hydroxytryptamine 1B, 1D, and 1F receptors and their role in controlling the release of calcitonin gene-related peptide in the rat trigeminovascular system. Pain. 153: 830-8. PMID 22305629 DOI: 10.1016/j.pain.2012.01.005  1
2012 Annedi SC, Ramnauth J, Maddaford SP, Renton P, Rakhit S, Mladenova G, Dove P, Silverman S, Andrews JS, Felice MD, Porreca F. Discovery of cis-N-(1-(4-(methylamino)cyclohexyl)indolin-6-yl)thiophene-2-carboximidamide: a 1,6-disubstituted indoline derivative as a highly selective inhibitor of human neuronal nitric oxide synthase (nNOS) without any cardiovascular liabilities. Journal of Medicinal Chemistry. 55: 943-55. PMID 22175766 DOI: 10.1021/jm201564u  1
2012 Nassini R, Materazzi S, Vriens J, Prenen J, Benemei S, De Siena G, la Marca G, Andrè E, Preti D, Avonto C, Sadofsky L, Di Marzo V, De Petrocellis L, Dussor G, Porreca F, et al. The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system. Brain : a Journal of Neurology. 135: 376-90. PMID 22036959 DOI: 10.1093/brain/awr272  1
2012 Marshall TM, Herman DS, Largent-Milnes TM, Badghisi H, Zuber K, Holt SC, Lai J, Porreca F, Vanderah TW. Activation of descending pain-facilitatory pathways from the rostral ventromedial medulla by cholecystokinin elicits release of prostaglandin-Eâ‚‚ in the spinal cord. Pain. 153: 86-94. PMID 22030324 DOI: 10.1016/j.pain.2011.09.021  1
2011 Sukhtankar D, Okun A, Chandramouli A, Nelson MA, Vanderah TW, Cress AE, Porreca F, King T. Inhibition of p38-MAPK signaling pathway attenuates breast cancer induced bone pain and disease progression in a murine model of cancer-induced bone pain. Molecular Pain. 7: 81. PMID 22014040 DOI: 10.1186/1744-8069-7-81  1
2011 De Caterina R, Griffioen AW, Porreca F. Fraud in biomedical research--the role of journal editors. Life Sciences. 89: 755-6. PMID 21983417 DOI: 10.1016/j.lfs.2011.09.016  1
2011 De Caterina R, Griffioen AW, Porreca F. Fraud in biomedical research - the role of journal Editors. Vascular Pharmacology. 55: 119-20. PMID 21983415 DOI: 10.1016/j.vph.2011.09.004  1
2011 Vardanyan R, Kumirov VK, Nichol GS, Davis P, Liktor-Busa E, Rankin D, Varga E, Vanderah T, Porreca F, Lai J, Hruby VJ. Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligands. Bioorganic & Medicinal Chemistry. 19: 6135-42. PMID 21925887 DOI: 10.1016/j.bmc.2011.08.027  1
2011 Annedi SC, Maddaford SP, Mladenova G, Ramnauth J, Rakhit S, Andrews JS, Lee DK, Zhang D, Porreca F, Bunton D, Christie L. Discovery of N-(3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-6-yl) thiophene-2-carboximidamide as a selective inhibitor of human neuronal nitric oxide synthase (nNOS) for the treatment of pain. Journal of Medicinal Chemistry. 54: 7408-16. PMID 21923116 DOI: 10.1021/jm201063u  1
2011 Yue X, Falk T, Zuniga LA, Szabò L, Porreca F, Polt R, Sherman SJ. Effects of the novel glycopeptide opioid agonist MMP-2200 in preclinical models of Parkinson's disease. Brain Research. 1413: 72-83. PMID 21840512 DOI: 10.1016/j.brainres.2011.07.038  1
2011 Maddaford S, Renton P, Speed J, Annedi SC, Ramnauth J, Rakhit S, Andrews J, Mladenova G, Majuta L, Porreca F. 1,6-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors. Bioorganic & Medicinal Chemistry Letters. 21: 5234-8. PMID 21824773 DOI: 10.1016/j.bmcl.2011.07.042  1
2011 De Felice M, Sanoja R, Wang R, Vera-Portocarrero L, Oyarzo J, King T, Ossipov MH, Vanderah TW, Lai J, Dussor GO, Fields HL, Price TJ, Porreca F. Engagement of descending inhibition from the rostral ventromedial medulla protects against chronic neuropathic pain. Pain. 152: 2701-9. PMID 21745713 DOI: 10.1016/j.pain.2011.06.008  1
2011 Fioravanti B, Kasasbeh A, Edelmayer R, Skinner DP, Hartings JA, Burklund RD, De Felice M, French ED, Dussor GO, Dodick DW, Porreca F, Vanderah TW. Evaluation of cutaneous allodynia following induction of cortical spreading depression in freely moving rats. Cephalalgia : An International Journal of Headache. 31: 1090-100. PMID 21700643 DOI: 10.1177/0333102411410609  1
2011 Ramnauth J, Speed J, Maddaford SP, Dove P, Annedi SC, Renton P, Rakhit S, Andrews J, Silverman S, Mladenova G, Zinghini S, Nair S, Catalano C, Lee DK, De Felice M, ... Porreca F, et al. Design, synthesis, and biological evaluation of 3,4-dihydroquinolin-2(1H)-one and 1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors. Journal of Medicinal Chemistry. 54: 5562-75. PMID 21699209 DOI: 10.1021/jm200648s  1
2011 King T, Qu C, Okun A, Mercado R, Ren J, Brion T, Lai J, Porreca F. Contribution of afferent pathways to nerve injury-induced spontaneous pain and evoked hypersensitivity. Pain. 152: 1997-2005. PMID 21620567 DOI: 10.1016/j.pain.2011.04.020  1
2011 Bannister K, Sikandar S, Bauer CS, Dolphin AC, Porreca F, Dickenson AH. Pregabalin suppresses spinal neuronal hyperexcitability and visceral hypersensitivity in the absence of peripheral pathophysiology. Anesthesiology. 115: 144-52. PMID 21602662 DOI: 10.1097/ALN.0b013e31821f6545  1
2011 Hanlon KE, Herman DS, Agnes RS, Largent-Milnes TM, Kumarasinghe IR, Ma SW, Guo W, Lee YS, Ossipov MH, Hruby VJ, Lai J, Porreca F, Vanderah TW. Novel peptide ligands with dual acting pharmacophores designed for the pathophysiology of neuropathic pain. Brain Research. 1395: 1-11. PMID 21550594 DOI: 10.1016/j.brainres.2011.04.024  1
2011 Asiedu MN, Tillu DV, Melemedjian OK, Shy A, Sanoja R, Bodell B, Ghosh S, Porreca F, Price TJ. Spinal protein kinase M ζ underlies the maintenance mechanism of persistent nociceptive sensitization. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 6646-53. PMID 21543593 DOI: 10.1523/JNEUROSCI.6286-10.2011  1
2011 Qu C, King T, Okun A, Lai J, Fields HL, Porreca F. Lesion of the rostral anterior cingulate cortex eliminates the aversiveness of spontaneous neuropathic pain following partial or complete axotomy. Pain. 152: 1641-8. PMID 21474245 DOI: 10.1016/j.pain.2011.03.002  1
2011 De Felice M, Ossipov MH, Porreca F. Persistent medication-induced neural adaptations, descending facilitation, and medication overuse headache. Current Opinion in Neurology. 24: 193-6. PMID 21467931 DOI: 10.1097/WCO.0b013e328346af25  1
2011 Meng ID, Dodick D, Ossipov MH, Porreca F. Pathophysiology of medication overuse headache: insights and hypotheses from preclinical studies. Cephalalgia : An International Journal of Headache. 31: 851-60. PMID 21444643 DOI: 10.1177/0333102411402367  1
2011 Ballet S, Feytens D, Buysse K, Chung NN, Lemieux C, Tumati S, Keresztes A, Van Duppen J, Lai J, Varga E, Porreca F, Schiller PW, Vanden Broeck J, Tourwé D. Design of novel neurokinin 1 receptor antagonists based on conformationally constrained aromatic amino acids and discovery of a potent chimeric opioid agonist-neurokinin 1 receptor antagonist. Journal of Medicinal Chemistry. 54: 2467-76. PMID 21413804 DOI: 10.1021/jm1016285  1
2011 Stagg NJ, Mata HP, Ibrahim MM, Henriksen EJ, Porreca F, Vanderah TW, Philip Malan T. Regular exercise reverses sensory hypersensitivity in a rat neuropathic pain model: role of endogenous opioids. Anesthesiology. 114: 940-8. PMID 21386701 DOI: 10.1097/ALN.0b013e318210f880  1
2011 Yamamoto T, Nair P, Largent-Milnes TM, Jacobsen NE, Davis P, Ma SW, Yamamura HI, Vanderah TW, Porreca F, Lai J, Hruby VJ. Discovery of a potent and efficacious peptide derivative for δ/μ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies. Journal of Medicinal Chemistry. 54: 2029-38. PMID 21366266 DOI: 10.1021/jm101023r  1
2011 Vera-Portocarrero LP, Ossipov MH, Lai J, King T, Porreca F. Descending facilitatory pathways from the rostroventromedial medulla mediate naloxone-precipitated withdrawal in morphine-dependent rats. The Journal of Pain : Official Journal of the American Pain Society. 12: 667-76. PMID 21354865 DOI: 10.1016/j.jpain.2010.12.007  1
2011 Hildebrand ME, Smith PL, Bladen C, Eduljee C, Xie JY, Chen L, Fee-Maki M, Doering CJ, Mezeyova J, Zhu Y, Belardetti F, Pajouhesh H, Parker D, Arneric SP, Parmar M, ... Porreca F, et al. A novel slow-inactivation-specific ion channel modulator attenuates neuropathic pain. Pain. 152: 833-43. PMID 21349638 DOI: 10.1016/j.pain.2010.12.035  1
2011 Liu P, Okun A, Ren J, Guo RC, Ossipov MH, Xie J, King T, Porreca F. Ongoing pain in the MIA model of osteoarthritis. Neuroscience Letters. 493: 72-5. PMID 21241772 DOI: 10.1016/j.neulet.2011.01.027  1
2011 Okun A, DeFelice M, Eyde N, Ren J, Mercado R, King T, Porreca F. Transient inflammation-induced ongoing pain is driven by TRPV1 sensitive afferents. Molecular Pain. 7: 4. PMID 21219650 DOI: 10.1186/1744-8069-7-4  1
2011 Lee YS, Kulkarani V, Cowell SM, Ma SW, Davis P, Hanlon KE, Vanderah TW, Lai J, Porreca F, Vardanyan R, Hruby VJ. Development of potent μ and δ opioid agonists with high lipophilicity. Journal of Medicinal Chemistry. 54: 382-6. PMID 21128594 DOI: 10.1021/jm100982d  1
2011 De Felice M, Ossipov MH, Porreca F. Update on medication-overuse headache. Current Pain and Headache Reports. 15: 79-83. PMID 21058047 DOI: 10.1007/s11916-010-0155-1  1
2011 Yan J, Edelmayer RM, Wei X, De Felice M, Porreca F, Dussor G. Dural afferents express acid-sensing ion channels: a role for decreased meningeal pH in migraine headache. Pain. 152: 106-13. PMID 20971560 DOI: 10.1016/j.pain.2010.09.036  1
2011 Mollica A, Pinnen F, Feliciani F, Stefanucci A, Lucente G, Davis P, Porreca F, Ma SW, Lai J, Hruby VJ. New potent biphalin analogues containing p-fluoro-L-phenylalanine at the 4,4' positions and non-hydrazine linkers. Amino Acids. 40: 1503-11. PMID 20924622 DOI: 10.1007/s00726-010-0760-7  1
2010 Ossipov MH, Dussor GO, Porreca F. Central modulation of pain. The Journal of Clinical Investigation. 120: 3779-87. PMID 21041960 DOI: 10.1172/JCI43766  1
2010 Weinreb PH, Wen D, Qian F, Wildes CP, Garber EA, Walus L, Jung MY, Wang J, Relton JK, Amatucci J, Wang R, Porreca F, Silvian L, Meier W, Pepinsky RB, et al. Resolution of disulfide heterogeneity in Nogo receptor I fusion proteins by molecular engineering. Biotechnology and Applied Biochemistry. 57: 31-45. PMID 20815818 DOI: 10.1042/BA20100061  1
2010 Lian B, Vera-Portocarrero L, King T, Ossipov MH, Porreca F. Opioid-induced latent sensitization in a model of non-inflammatory viscerosomatic hypersensitivity. Brain Research. 1358: 64-70. PMID 20727859 DOI: 10.1016/j.brainres.2010.08.032  1
2010 Giordano C, Sansone A, Masi A, Lucente G, Punzi P, Mollica A, Pinnen F, Feliciani F, Cacciatore I, Davis P, Lai J, Ma SW, Porreca F, Hruby V. Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2. European Journal of Medicinal Chemistry. 45: 4594-600. PMID 20692738 DOI: 10.1016/j.ejmech.2010.07.022  1
2010 De Felice M, Ossipov MH, Wang R, Dussor G, Lai J, Meng ID, Chichorro J, Andrews JS, Rakhit S, Maddaford S, Dodick D, Porreca F. Triptan-induced enhancement of neuronal nitric oxide synthase in trigeminal ganglion dural afferents underlies increased responsiveness to potential migraine triggers. Brain : a Journal of Neurology. 133: 2475-88. PMID 20627971 DOI: 10.1093/brain/awq159  1
2010 Yamamoto T, Nair P, Jacobsen NE, Kulkarni V, Davis P, Ma SW, Navratilova E, Yamamura HI, Vanderah TW, Porreca F, Lai J, Hruby VJ. Biological and conformational evaluation of bifunctional compounds for opioid receptor agonists and neurokinin 1 receptor antagonists possessing two penicillamines. Journal of Medicinal Chemistry. 53: 5491-501. PMID 20617791 DOI: 10.1021/jm100157m  1
2010 Vardanyan M, Melemedjian OK, Price TJ, Ossipov MH, Lai J, Roberts E, Boos TL, Deschamps JR, Jacobson AE, Rice KC, Porreca F. Reversal of pancreatitis-induced pain by an orally available, small molecule interleukin-6 receptor antagonist. Pain. 151: 257-65. PMID 20599324 DOI: 10.1016/j.pain.2010.05.022  1
2010 Lee YS, Fernandes S, Kulkarani V, Mayorov A, Davis P, Ma SW, Brown K, Gillies RJ, Lai J, Porreca F, Hruby VJ. Design and synthesis of trivalent ligands targeting opioid, cholecystokinin, and melanocortin receptors for the treatment of pain. Bioorganic & Medicinal Chemistry Letters. 20: 4080-4. PMID 20547453 DOI: 10.1016/j.bmcl.2010.05.078  1
2010 Chen Q, Vera-Portocarrero LP, Ossipov MH, Vardanyan M, Lai J, Porreca F. Attenuation of persistent experimental pancreatitis pain by a bradykinin b2 receptor antagonist. Pancreas. 39: 1220-5. PMID 20531238 DOI: 10.1097/MPA.0b013e3181df1c90  1
2010 Torino D, Mollica A, Pinnen F, Feliciani F, Lucente G, Fabrizi G, Portalone G, Davis P, Lai J, Ma SW, Porreca F, Hruby VJ. Synthesis and evaluation of new endomorphin-2 analogues containing (Z)-alpha,beta-didehydrophenylalanine (Delta(Z)Phe) residues. Journal of Medicinal Chemistry. 53: 4550-4. PMID 20476738 DOI: 10.1021/jm1001343  1
2010 De Felice M, Ossipov MH, Wang R, Lai J, Chichorro J, Meng I, Dodick DW, Vanderah TW, Dussor G, Porreca F. Triptan-induced latent sensitization: a possible basis for medication overuse headache. Annals of Neurology. 67: 325-37. PMID 20373344 DOI: 10.1002/ana.21897  1
2010 Pajouhesh H, Feng ZP, Ding Y, Zhang L, Pajouhesh H, Morrison JL, Belardetti F, Tringham E, Simonson E, Vanderah TW, Porreca F, Zamponi GW, Mitscher LA, Snutch TP. Structure-activity relationships of diphenylpiperazine N-type calcium channel inhibitors. Bioorganic & Medicinal Chemistry Letters. 20: 1378-83. PMID 20117000 DOI: 10.1016/j.bmcl.2010.01.008  1
2009 Sroka IC, Pond GD, Nagle RB, Porreca F, King T, Pestano G, Futscher BW, Gard JM, Riley J, Cress AE. Human Cell Surface Receptors as Molecular Imaging Candidates for Metastatic Prostate Cancer. The Open Prostate Cancer Journal. 2: 59-66. PMID 22081777 DOI: 10.2174/1876822900902010059  0.72
2009 Yamamoto T, Nair P, Jacobsen NE, Vagner J, Kulkarni V, Davis P, Ma SW, Navratilova E, Yamamura HI, Vanderah TW, Porreca F, Lai J, Hruby VJ. Improving metabolic stability by glycosylation: bifunctional peptide derivatives that are opioid receptor agonists and neurokinin 1 receptor antagonists. Journal of Medicinal Chemistry. 52: 5164-75. PMID 20560643 DOI: 10.1021/jm900473p  1
2009 Okada-Ogawa A, Porreca F, Meng ID. Sustained morphine-induced sensitization and loss of diffuse noxious inhibitory controls in dura-sensitive medullary dorsal horn neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 15828-35. PMID 20016098 DOI: 10.1523/JNEUROSCI.3623-09.2009  1
2009 King T, Vera-Portocarrero L, Gutierrez T, Vanderah TW, Dussor G, Lai J, Fields HL, Porreca F. Unmasking the tonic-aversive state in neuropathic pain. Nature Neuroscience. 12: 1364-6. PMID 19783992 DOI: 10.1038/nn.2407  1
2009 Yamamoto T, Nair P, Ma SW, Davis P, Yamamura HI, Vanderah TW, Porreca F, Lai J, Hruby VJ. The biological activity and metabolic stability of peptidic bifunctional compounds that are opioid receptor agonists and neurokinin-1 receptor antagonists with a cystine moiety. Bioorganic & Medicinal Chemistry. 17: 7337-43. PMID 19762245 DOI: 10.1016/j.bmc.2009.08.035  1
2009 Roberts J, Ossipov MH, Porreca F. Glial activation in the rostroventromedial medulla promotes descending facilitation to mediate inflammatory hypersensitivity. The European Journal of Neuroscience. 30: 229-41. PMID 19614984 DOI: 10.1111/j.1460-9568.2009.06813.x  1
2009 Torino D, Mollica A, Pinnen F, Lucente G, Feliciani F, Davis P, Lai J, Ma SW, Porreca F, Hruby VJ. Synthesis and evaluation of new endomorphin analogues modified at the Pro(2) residue. Bioorganic & Medicinal Chemistry Letters. 19: 4115-8. PMID 19560919 DOI: 10.1016/j.bmcl.2009.06.008  1
2009 Vardanyan R, Vijay G, Nichol GS, Liu L, Kumarasinghe I, Davis P, Vanderah T, Porreca F, Lai J, Hruby VJ. Synthesis and investigations of double-pharmacophore ligands for treatment of chronic and neuropathic pain. Bioorganic & Medicinal Chemistry. 17: 5044-53. PMID 19540763 DOI: 10.1016/j.bmc.2009.05.065  1
2009 Dogrul A, Ossipov MH, Porreca F. Differential mediation of descending pain facilitation and inhibition by spinal 5HT-3 and 5HT-7 receptors. Brain Research. 1280: 52-9. PMID 19427839 DOI: 10.1016/j.brainres.2009.05.001  1
2009 Nair P, Yamamoto T, Kulkarni V, Moye S, Navratilova E, Davis P, Largent T, Ma SW, Yamamura HI, Vanderah T, Lai J, Porreca F, Hruby VJ. Novel bifunctional peptides as opioid agonists and NK-1 antagonists. Advances in Experimental Medicine and Biology. 611: 537-8. PMID 19400302 DOI: 10.1007/978-0-387-73657-0_235  1
2009 Lee Y, Petrov R, Kulkarni V, Min BJ, Ma SW, Davis P, Oyarzo J, Vanderah T, Lai J, Porreca F, Vardanyan R, Hruby VJ. Development of mu/delta opioid ligands: enkephalin analogues containing 4-anilidopiperidine moiety. Advances in Experimental Medicine and Biology. 611: 517-8. PMID 19400292 DOI: 10.1007/978-0-387-73657-0_225  1
2009 Kulkarni VV, Lee YS, Salibay C, Davis P, Ma SW, Porreca F, Hruby VJ. Novel analogues of bifunctional ligands for opioid and melanocortin 4 receptor. Advances in Experimental Medicine and Biology. 611: 195-6. PMID 19400157 DOI: 10.1007/978-0-387-73657-0_90  1
2009 Porreca F, Ossipov MH. Nausea and vomiting side effects with opioid analgesics during treatment of chronic pain: mechanisms, implications, and management options. Pain Medicine (Malden, Mass.). 10: 654-62. PMID 19302436 DOI: 10.1111/j.1526-4637.2009.00583.x  1
2009 Edelmayer RM, Vanderah TW, Majuta L, Zhang ET, Fioravanti B, De Felice M, Chichorro JG, Ossipov MH, King T, Lai J, Kori SH, Nelsen AC, Cannon KE, Heinricher MM, Porreca F. Medullary pain facilitating neurons mediate allodynia in headache-related pain. Annals of Neurology. 65: 184-93. PMID 19259966 DOI: 10.1002/ana.21537  1
2009 Rivat C, Vera-Portocarrero LP, Ibrahim MM, Mata HP, Stagg NJ, De Felice M, Porreca F, Malan TP. Spinal NK-1 receptor-expressing neurons and descending pathways support fentanyl-induced pain hypersensitivity in a rat model of postoperative pain. The European Journal of Neuroscience. 29: 727-37. PMID 19200067 DOI: 10.1111/j.1460-9568.2009.06616.x  1
2009 Porreca F, Vanderah TW. Spring pain research conference 2008. Brain Research Reviews. 60: 1. PMID 19150467 DOI: 10.1016/j.brainresrev.2008.12.022  1
2009 Zhang W, Gardell S, Zhang D, Xie JY, Agnes RS, Badghisi H, Hruby VJ, Rance N, Ossipov MH, Vanderah TW, Porreca F, Lai J. Neuropathic pain is maintained by brainstem neurons co-expressing opioid and cholecystokinin receptors. Brain : a Journal of Neurology. 132: 778-87. PMID 19050032 DOI: 10.1093/brain/awn330  1
2009 Vardanyan A, Wang R, Vanderah TW, Ossipov MH, Lai J, Porreca F, King T. TRPV1 receptor in expression of opioid-induced hyperalgesia. The Journal of Pain : Official Journal of the American Pain Society. 10: 243-52. PMID 18774343 DOI: 10.1016/j.jpain.2008.07.004  1
2008 Fioravanti B, De Felice M, Stucky CL, Medler KA, Luo MC, Gardell LR, Ibrahim M, Malan TP, Yamamura HI, Ossipov MH, King T, Lai J, Porreca F, Vanderah TW. Constitutive activity at the cannabinoid CB1 receptor is required for behavioral response to noxious chemical stimulation of TRPV1: antinociceptive actions of CB1 inverse agonists. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 11593-602. PMID 18987195 DOI: 10.1523/JNEUROSCI.3322-08.2008  1
2008 Luo MC, Chen Q, Ossipov MH, Rankin DR, Porreca F, Lai J. Spinal dynorphin and bradykinin receptors maintain inflammatory hyperalgesia. The Journal of Pain : Official Journal of the American Pain Society. 9: 1096-105. PMID 18976961 DOI: 10.1016/j.jpain.2008.06.005  1
2008 King TE, Pawar SC, Majuta L, Sroka IC, Wynn D, Demetriou MC, Nagle RB, Porreca F, Cress AE. The role of alpha 6 integrin in prostate cancer migration and bone pain in a novel xenograft model. Plos One. 3: e3535. PMID 18958175 DOI: 10.1371/journal.pone.0003535  1
2008 Yamamoto T, Nair P, Jacobsen NE, Davis P, Ma SW, Navratilova E, Moye S, Lai J, Yamamura HI, Vanderah TW, Porreca F, Hruby VJ. The importance of micelle-bound states for the bioactivities of bifunctional peptide derivatives for delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists. Journal of Medicinal Chemistry. 51: 6334-47. PMID 18821747 DOI: 10.1021/jm800389v  1
2008 Vera-Portocarrero LP, Ossipov MH, King T, Porreca F. Reversal of inflammatory and noninflammatory visceral pain by central or peripheral actions of sumatriptan. Gastroenterology. 135: 1369-78. PMID 18694754 DOI: 10.1053/j.gastro.2008.06.085  1
2008 Agnes RS, Ying J, Kövér KE, Lee YS, Davis P, Ma SW, Badghisi H, Porreca F, Lai J, Hruby VJ. Structure-activity relationships of bifunctional cyclic disulfide peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. Peptides. 29: 1413-23. PMID 18502541 DOI: 10.1016/j.peptides.2008.03.022  1
2008 Lai J, Luo MC, Chen Q, Porreca F. Pronociceptive actions of dynorphin via bradykinin receptors. Neuroscience Letters. 437: 175-9. PMID 18450375 DOI: 10.1016/j.neulet.2008.03.088  1
2008 Wang R, King T, Ossipov MH, Rossomando AJ, Vanderah TW, Harvey P, Cariani P, Frank E, Sah DW, Porreca F. Persistent restoration of sensory function by immediate or delayed systemic artemin after dorsal root injury. Nature Neuroscience. 11: 488-96. PMID 18344995 DOI: 10.1038/nn2069  1
2008 Vanderah TW, Largent-Milnes T, Lai J, Porreca F, Houghten RA, Menzaghi F, Wisniewski K, Stalewski J, Sueiras-Diaz J, Galyean R, Schteingart C, Junien JL, Trojnar J, Rivière PJ. Novel D-amino acid tetrapeptides produce potent antinociception by selectively acting at peripheral kappa-opioid receptors. European Journal of Pharmacology. 583: 62-72. PMID 18282565 DOI: 10.1016/j.ejphar.2008.01.011  1
2008 Yamamoto T, Nair P, Vagner J, Largent-Milnes T, Davis P, Ma SW, Navratilova E, Moye S, Tumati S, Lai J, Yamamura HI, Vanderah TW, Porreca F, Hruby VJ. A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists. Journal of Medicinal Chemistry. 51: 1369-76. PMID 18266313 DOI: 10.1021/jm070332f  1
2008 Salvadori S, Fiorini S, Trapella C, Porreca F, Davis P, Sasaki Y, Ambo A, Marczak ED, Lazarus LH, Balboni G. Role of benzimidazole (Bid) in the delta-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH(2)-Bid (UFP-502). Bioorganic & Medicinal Chemistry. 16: 3032-8. PMID 18178091 DOI: 10.1016/j.bmc.2007.12.032  1
2008 Lee YS, Agnes RS, Cain JP, Kulkarni V, Cai M, Salibay C, Ciano K, Petrov R, Mayorov A, Vagner J, Trivedi D, Davis P, Ma SW, Lai J, Porreca F, et al. Opioid and melanocortin receptors: do they have overlapping pharmacophores? Biopolymers. 90: 433-8. PMID 17657709 DOI: 10.1002/bip.20814  1
2007 Khanolkar AD, Lu D, Ibrahim M, Duclos RI, Thakur GA, Malan TP, Porreca F, Veerappan V, Tian X, George C, Parrish DA, Papahatjis DP, Makriyannis A. Cannabilactones: a novel class of CB2 selective agonists with peripheral analgesic activity. Journal of Medicinal Chemistry. 50: 6493-500. PMID 18038967 DOI: 10.1021/jm070441u  1
2007 Muscoli C, Cuzzocrea S, Ndengele MM, Mollace V, Porreca F, Fabrizi F, Esposito E, Masini E, Matuschak GM, Salvemini D. Therapeutic manipulation of peroxynitrite attenuates the development of opiate-induced antinociceptive tolerance in mice. The Journal of Clinical Investigation. 117: 3530-9. PMID 17975673 DOI: 10.1172/JCI32420  1
2007 Lee YS, Petrov R, Park CK, Ma SW, Davis P, Lai J, Porreca F, Vardanyan R, Hruby VJ. Development of novel enkephalin analogues that have enhanced opioid activities at both mu and delta opioid receptors. Journal of Medicinal Chemistry. 50: 5528-32. PMID 17927164 DOI: 10.1021/jm061465o  1
2007 King T, Vardanyan A, Majuta L, Melemedjian O, Nagle R, Cress AE, Vanderah TW, Lai J, Porreca F. Morphine treatment accelerates sarcoma-induced bone pain, bone loss, and spontaneous fracture in a murine model of bone cancer. Pain. 132: 154-68. PMID 17706870 DOI: 10.1016/j.pain.2007.06.026  1
2007 Ossipov MH, Bazov I, Gardell LR, Kowal J, Yakovleva T, Usynin I, Ekström TJ, Porreca F, Bakalkin G. Control of chronic pain by the ubiquitin proteasome system in the spinal cord. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 8226-37. PMID 17670969 DOI: 10.1523/JNEUROSCI.5126-06.2007  1
2007 Mollica A, Guardiani G, Davis P, Ma SW, Porreca F, Lai J, Mannina L, Sobolev AP, Hruby VJ. Synthesis of stable and potent delta/mu opioid peptides: analogues of H-Tyr-c[D-Cys-Gly-Phe-D-Cys]-OH by ring-closing metathesis. Journal of Medicinal Chemistry. 50: 3138-42. PMID 17539621 DOI: 10.1021/jm061048b  1
2007 Yamamoto T, Nair P, Davis P, Ma SW, Navratilova E, Moye S, Tumati S, Lai J, Vanderah TW, Yamamura HI, Porreca F, Hruby VJ. Design, synthesis, and biological evaluation of novel bifunctional C-terminal-modified peptides for delta/mu opioid receptor agonists and neurokinin-1 receptor antagonists. Journal of Medicinal Chemistry. 50: 2779-86. PMID 17516639 DOI: 10.1021/jm061369n  1
2007 Dogrul A, Gülmez SE, Deveci MS, Gul H, Ossipov MH, Porreca F, Tulunay FC. The local antinociceptive actions of nonsteroidal antiinflammatory drugs in the mouse radiant heat tail-flick test. Anesthesia and Analgesia. 104: 927-35. PMID 17377109 DOI: 10.1213/01.ane.0000258773.46897.34  1
2007 Lee YS, Nyberg J, Moye S, Agnes RS, Davis P, Ma SW, Lai J, Porreca F, Vardanyan R, Hruby VJ. Understanding the structural requirements of 4-anilidopiperidine analogues for biological activities at mu and delta opioid receptors. Bioorganic & Medicinal Chemistry Letters. 17: 2161-5. PMID 17329100 DOI: 10.1016/j.bmcl.2007.01.114  1
2007 Lowery JJ, Yeomans L, Keyari CM, Davis P, Porreca F, Knapp BI, Bidlack JM, Bilsky EJ, Polt R. Glycosylation improves the central effects of DAMGO. Chemical Biology & Drug Design. 69: 41-7. PMID 17313456 DOI: 10.1111/j.1747-0285.2007.00462.x  1
2007 Martin TJ, Kim SA, Buechler NL, Porreca F, Eisenach JC. Opioid self-administration in the nerve-injured rat: relevance of antiallodynic effects to drug consumption and effects of intrathecal analgesics. Anesthesiology. 106: 312-22. PMID 17264726 DOI: 10.1097/00000542-200702000-00020  1
2007 Lee YS, Agnes RS, Davis P, Ma SW, Badghisi H, Lai J, Porreca F, Hruby VJ. Partial retro-inverso, retro, and inverso modifications of hydrazide linked bifunctional peptides for opioid and cholecystokinin (CCK) receptors. Journal of Medicinal Chemistry. 50: 165-8. PMID 17201419 DOI: 10.1021/jm061268p  1
2007 Zhang ET, Ossipov MH, Zhang DQ, Lai J, Porreca F. Nerve injury-induced tactile allodynia is present in the absence of FOS labeling in retrogradely labeled post-synaptic dorsal column neurons. Pain. 129: 143-54. PMID 17156921 DOI: 10.1016/j.pain.2006.10.009  1
2007 Vera-Portocarrero LP, Zhang ET, King T, Ossipov MH, Vanderah TW, Lai J, Porreca F. Spinal NK-1 receptor expressing neurons mediate opioid-induced hyperalgesia and antinociceptive tolerance via activation of descending pathways. Pain. 129: 35-45. PMID 17123731 DOI: 10.1016/j.pain.2006.09.033  1
2007 Shinoda K, Hruby VJ, Porreca F. Antihyperalgesic effects of loperamide in a model of rat neuropathic pain are mediated by peripheral delta-opioid receptors. Neuroscience Letters. 411: 143-6. PMID 17110034 DOI: 10.1016/j.neulet.2006.10.027  1
2006 Ossipov MH, Porreca F. Chapter 14 Descending excitatory systems. Handbook of Clinical Neurology. 81: 193-210. PMID 18808836 DOI: 10.1016/S0072-9752(06)80018-7  1
2006 Ndungu JM, Cain JP, Davis P, Ma SW, Vanderah TW, Lai J, Porreca F, Hruby VJ. Synthesis of constrained analogues of cholecystokinin/opioid chimeric peptides. Tetrahedron Letters. 47: 2233-2236. PMID 17203138 DOI: 10.1016/j.tetlet.2006.01.096  1
2006 Lai J, Luo MC, Chen Q, Ma S, Gardell LR, Ossipov MH, Porreca F. Dynorphin A activates bradykinin receptors to maintain neuropathic pain. Nature Neuroscience. 9: 1534-40. PMID 17115041 DOI: 10.1038/nn1804  1
2006 Hruby VJ, Porreca F, Yamamura HI, Tollin G, Agnes RS, Lee YS, Cai M, Alves I, Cowell S, Varga E, Davis P, Salamon Z, Roeske W, Vanderah T, Lai J. New paradigms and tools in drug design for pain and addiction. The Aaps Journal. 8: E450-60. PMID 17025262 DOI: 10.1208/aapsj080353  1
2006 Suzuki R, Porreca F, Dickenson AH. Evidence for spinal dorsal horn hyperexcitability in rats following sustained morphine exposure. Neuroscience Letters. 407: 156-61. PMID 16959420 DOI: 10.1016/j.neulet.2006.08.027  1
2006 Petrov RR, Vardanyan RS, Lee YS, Ma SW, Davis P, Begay LJ, Lai JY, Porreca F, Hruby VJ. Synthesis and evaluation of 3-aminopropionyl substituted fentanyl analogues for opioid activity. Bioorganic & Medicinal Chemistry Letters. 16: 4946-50. PMID 16828552 DOI: 10.1016/j.bmcl.2006.06.040  1
2006 King T, Rao S, Vanderah T, Chen Q, Vardanyan A, Porreca F. Differential blockade of nerve injury-induced shift in weight bearing and thermal and tactile hypersensitivity by milnacipran. The Journal of Pain : Official Journal of the American Pain Society. 7: 513-20. PMID 16814690 DOI: 10.1016/j.jpain.2006.02.001  1
2006 Negri L, Lattanzi R, Giannini E, Colucci M, Margheriti F, Melchiorri P, Vellani V, Tian H, De Felice M, Porreca F. Impaired nociception and inflammatory pain sensation in mice lacking the prokineticin receptor PKR1: focus on interaction between PKR1 and the capsaicin receptor TRPV1 in pain behavior. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 6716-27. PMID 16793879 DOI: 10.1523/JNEUROSCI.5403-05.2006  1
2006 Vera-Portocarrero LP, Xie JY, Yie JX, Kowal J, Ossipov MH, King T, Porreca F. Descending facilitation from the rostral ventromedial medulla maintains visceral pain in rats with experimental pancreatitis. Gastroenterology. 130: 2155-64. PMID 16762636 DOI: 10.1053/j.gastro.2006.03.025  1
2006 Agnes RS, Lee YS, Davis P, Ma SW, Badghisi H, Porreca F, Lai J, Hruby VJ. Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. Journal of Medicinal Chemistry. 49: 2868-75. PMID 16686530 DOI: 10.1021/jm050921q  1
2006 Amir R, Argoff CE, Bennett GJ, Cummins TR, Durieux ME, Gerner P, Gold MS, Porreca F, Strichartz GR. The role of sodium channels in chronic inflammatory and neuropathic pain. The Journal of Pain : Official Journal of the American Pain Society. 7: S1-29. PMID 16632328 DOI: 10.1016/j.jpain.2006.01.444  1
2006 Gardell LR, King T, Ossipov MH, Rice KC, Lai J, Vanderah TW, Porreca F. Opioid receptor-mediated hyperalgesia and antinociceptive tolerance induced by sustained opiate delivery. Neuroscience Letters. 396: 44-9. PMID 16343768 DOI: 10.1016/j.neulet.2005.11.009  1
2005 King T, Gardell LR, Wang R, Vardanyan A, Ossipov MH, Malan TP, Vanderah TW, Hunt SP, Hruby VJ, Lai J, Porreca F. Role of NK-1 neurotransmission in opioid-induced hyperalgesia. Pain. 116: 276-88. PMID 15964684 DOI: 10.1016/j.pain.2005.04.014  1
2005 Xie JY, Herman DS, Stiller CO, Gardell LR, Ossipov MH, Lai J, Porreca F, Vanderah TW. Cholecystokinin in the rostral ventromedial medulla mediates opioid-induced hyperalgesia and antinociceptive tolerance. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 409-16. PMID 15647484 DOI: 10.1523/JNEUROSCI.4054-04.2005  1
2004 Chen Q, King T, Vanderah TW, Ossipov MH, Malan TP, Lai J, Porreca F. Differential blockade of nerve injury-induced thermal and tactile hypersensitivity by systemically administered brain-penetrating and peripherally restricted local anesthetics. The Journal of Pain : Official Journal of the American Pain Society. 5: 281-9. PMID 15219260 DOI: 10.1016/j.jpain.2004.05.002  1
2003 Gardell LR, Wang R, Ehrenfels C, Ossipov MH, Rossomando AJ, Miller S, Buckley C, Cai AK, Tse A, Foley SF, Gong B, Walus L, Carmillo P, Worley D, Huang C, ... ... Porreca F, et al. Multiple actions of systemic artemin in experimental neuropathy. Nature Medicine. 9: 1383-9. PMID 14528299 DOI: 10.1038/nm944  1
2003 Dogrul A, Gardell LR, Ossipov MH, Tulunay FC, Lai J, Porreca F. Reversal of experimental neuropathic pain by T-type calcium channel blockers. Pain. 105: 159-68. PMID 14499432 DOI: 10.1016/S0304-3959(03)00177-5  1
2003 Gold MS, Weinreich D, Kim CS, Wang R, Treanor J, Porreca F, Lai J. Redistribution of Na(V)1.8 in uninjured axons enables neuropathic pain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 158-66. PMID 12514212  1
2002 Dogrul A, Gardell LR, Ma S, Ossipov MH, Porreca F, Lai J. 'Knock-down' of spinal CB1 receptors produces abnormal pain and elevates spinal dynorphin content in mice. Pain. 100: 203-9. PMID 12435473 DOI: 10.1016/S0304-3959(02)00302-0  1
2002 Gardell LR, Wang R, Burgess SE, Ossipov MH, Vanderah TW, Malan TP, Lai J, Porreca F. Sustained morphine exposure induces a spinal dynorphin-dependent enhancement of excitatory transmitter release from primary afferent fibers. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 6747-55. PMID 12151554  1
2002 Burgess SE, Gardell LR, Ossipov MH, Malan TP, Vanderah TW, Lai J, Porreca F. Time-dependent descending facilitation from the rostral ventromedial medulla maintains, but does not initiate, neuropathic pain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 5129-36. PMID 12077208  1
2002 Lai J, Gold MS, Kim CS, Bian D, Ossipov MH, Hunter JC, Porreca F. Inhibition of neuropathic pain by decreased expression of the tetrodotoxin-resistant sodium channel, NaV1.8. Pain. 95: 143-52. PMID 11790477  0.88
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