Frank Porreca - Publications

Affiliations: 
University of Arizona, Tucson, AZ 
Area:
pain, opioids, pharmacology

493 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Phelps CE, Navratilova E, Porreca F. Cognition in the Chronic Pain Experience: Preclinical Insights. Trends in Cognitive Sciences. PMID 33509733 DOI: 10.1016/j.tics.2021.01.001  0.76
2021 Bannister K, Kucharczyk MW, Graven-Nielsen T, Porreca F. Introducing descending control of nociception: a measure of diffuse noxious inhibitory controls in conscious animals. Pain. PMID 33470750 DOI: 10.1097/j.pain.0000000000002203  0.36
2021 Hein M, Ji G, Tidwell D, D'Souza P, Kiritoshi T, Yakhnitsa V, Navratilova E, Porreca F, Neugebauer V. Kappa opioid receptor activation in the amygdala disinhibits CRF neurons to generate pain-like behaviors. Neuropharmacology. 185: 108456. PMID 33444637 DOI: 10.1016/j.neuropharm.2021.108456  0.76
2020 Martin L, Porreca F, Mata EI, Salloum M, Goel V, Gunnala P, Killgore WDS, Jain S, Jones-MacFarland FN, Khanna R, Patwardhan A, Ibrahim MM. Green Light Exposure Improves Pain and Quality of Life in Fibromyalgia Patients: A Preliminary One-Way Crossover Clinical Trial. Pain Medicine (Malden, Mass.). PMID 33155057 DOI: 10.1093/pm/pnaa329  0.68
2020 Kopruszinski CM, Thornton P, Arnold J, Newton P, Lowne D, Navratilova E, Swiokla J, Dodick DW, Dobson C, Gurrell I, Chessell IP, Porreca F. Characterization and preclinical evaluation of a protease activated receptor 2 (PAR2) monoclonal antibody as a preventive therapy for migraine. Cephalalgia : An International Journal of Headache. 333102420966581. PMID 33131305 DOI: 10.1177/0333102420966581  0.76
2020 Raghuraman S, Xie JY, Giacobassi MJ, Tun JO, Chase K, Lu D, Teichert RW, Porreca F, Olivera BM. Chronicling changes in the somatosensory neurons after peripheral nerve injury. Proceedings of the National Academy of Sciences of the United States of America. PMID 33020310 DOI: 10.1073/pnas.1922618117  0.72
2020 Martin LF, Patwardhan AM, Jain SV, Salloum MM, Freeman J, Khanna R, Gannala P, Goel V, Jones-MacFarland FN, Killgore WD, Porreca F, Ibrahim MM. Evaluation of green light exposure on headache frequency and quality of life in migraine patients: A preliminary one-way cross-over clinical trial. Cephalalgia : An International Journal of Headache. 333102420956711. PMID 32903062 DOI: 10.1177/0333102420956711  0.68
2020 Chen Y, Navratilova E, Dodick DW, Porreca F. An Emerging Role for Prolactin in Female-Selective Pain. Trends in Neurosciences. PMID 32620290 DOI: 10.1016/j.tins.2020.06.003  0.76
2020 Navratilova E, Behravesh S, Oyarzo J, Dodick DW, Banerjee P, Porreca F. Ubrogepant does not induce latent sensitization in a preclinical model of medication overuse headache. Cephalalgia : An International Journal of Headache. 333102420938652. PMID 32615788 DOI: 10.1177/0333102420938652  0.76
2020 Rau JC, Navratilova E, Oyarzo J, Johnson KW, Aurora SK, Schwedt TJ, Dodick DW, Porreca F. Evaluation of LY573144 (lasmiditan) in a preclinical model of medication overuse headache. Cephalalgia : An International Journal of Headache. 333102420920006. PMID 32580575 DOI: 10.1177/0333102420920006  0.76
2020 Gee TA, Weintraub NC, Lu D, Phelps CE, Navratilova E, Heien ML, Porreca F. A pain-induced tonic hypodopaminergic state augments phasic dopamine release in the nucleus accumbens. Pain. PMID 32453137 DOI: 10.1097/j.pain.0000000000001925  0.76
2020 Neugebauer V, Mazzitelli M, Cragg B, Ji G, Navratilova E, Porreca F. Amygdala, neuropeptides, and chronic pain-related affective behaviors. Neuropharmacology. 108052. PMID 32188569 DOI: 10.1016/j.neuropharm.2020.108052  0.76
2020 Kopruszinski CM, Swiokla J, Lee YS, Navratilova E, VanderVeen L, Yang M, Liu Y, Miyazaki T, Schmidt WK, Zalevsky J, Porreca F. Preclinical Assessment of the Analgesic Pharmacology of NKTR-181 in Rodents. Cellular and Molecular Neurobiology. PMID 32107752 DOI: 10.1007/s10571-020-00816-3  0.76
2020 Chen Y, Moutal A, Navratilova E, Kopruszinski C, Yue X, Ikegami M, Chow M, Kanazawa I, Bellampalli SS, Xie J, Patwardhan A, Rice K, Fields H, Akopian A, Neugebauer V, ... ... Porreca F, et al. The prolactin receptor long isoform regulates nociceptor sensitization and opioid-induced hyperalgesia selectively in females. Science Translational Medicine. 12. PMID 32024801 DOI: 10.1126/scitranslmed.aay7550  0.76
2020 Dickenson AH, Navratilova E, Patel R, Porreca F, Bannister K. Supraspinal Opioid Circuits Differentially Modulate Spinal Neuronal Responses in Neuropathic Rats. Anesthesiology. PMID 31977518 DOI: 10.1097/ALN.0000000000003120  0.76
2019 Christensen SL, Hansen RB, Storm MA, Olesen J, Hansen TF, Ossipov M, Izarzugaza JMG, Porreca F, Kristensen DM. Von Frey testing revisited - provision of an online algorithm for improved accuracy of 50% thresholds. European Journal of Pain (London, England). PMID 31889375 DOI: 10.1002/ejp.1528  0.36
2019 Khanna R, Patwardhan A, Yang X, Li W, Cai S, Ji Y, Chew LA, Dorame A, Bellampalli SS, Schmoll RW, Gordon J, Moutal A, Vanderah TW, Porreca F, Ibrahim MM. Erratum to ‛Development and Characterization of An Injury-free Model of Functional Pain in Rats by Exposure to Red Light': The Journal of Pain 20 (2019) 1293-1306. The Journal of Pain : Official Journal of the American Pain Society. 20: 1509. PMID 31818395 DOI: 10.1016/j.jpain.2019.11.012  1
2019 Navratilova E, Nation K, Remeniuk B, Neugebauer V, Bannister K, Dickenson AH, Porreca F. Selective modulation of tonic aversive qualities of neuropathic pain by morphine in the central nucleus of the amygdala requires endogenous opioid signaling in the anterior cingulate cortex. Pain. PMID 31725062 DOI: 10.1097/j.pain.0000000000001748  0.76
2019 Navratilova E, Rau J, Oyarzo J, Tien J, Mackenzie K, Stratton J, Remeniuk B, Schwedt T, Anderson T, Dodick D, Porreca F. CGRP-dependent and independent mechanisms of acute and persistent post-traumatic headache following mild traumatic brain injury in mice. Cephalalgia : An International Journal of Headache. 333102419877662. PMID 31550910 DOI: 10.1177/0333102419877662  0.76
2019 Ashina H, Porreca F, Anderson T, Mohammad Amin F, Ashina M, Winther Schytz H, Dodick DW. Post-traumatic headache: epidemiology and pathophysiological insights. Nature Reviews. Neurology. PMID 31527806 DOI: 10.1038/s41582-019-0243-8  0.68
2019 Xie JY, Qu C, Munro G, Petersen KA, Porreca F. Antihyperalgesic effects of Meteorin in the rat chronic constriction injury model: a replication study. Pain. 160: 1847-1855. PMID 31335652 DOI: 10.1097/j.pain.0000000000001569  0.72
2019 Kopruszinski CM, Navratilova E, Vagnerova B, Swiokla J, Patwardhan A, Dodick D, Porreca F. Cannabinoids induce latent sensitization in a preclinical model of medication overuse headache. Cephalalgia : An International Journal of Headache. 333102419865252. PMID 31311288 DOI: 10.1177/0333102419865252  0.76
2019 Diener HC, Dodick D, Evers S, Holle D, Jensen RH, Lipton RB, Porreca F, Silberstein S, Schwedt T. Pathophysiology, prevention, and treatment of medication overuse headache. The Lancet. Neurology. PMID 31174999 DOI: 10.1016/S1474-4422(19)30146-2  0.4
2019 Khanna R, Patwardhan A, Yang X, Li W, Cai S, Ji Y, Chew LA, Dorame A, Bellampalli SS, Schmoll RW, Gordon J, Moutal A, Vanderah TW, Porreca F, Ibrahim MM. Development and Characterization of An Injury-free Model of Functional Pain in Rats by Exposure to Red Light. The Journal of Pain : Official Journal of the American Pain Society. PMID 31054915 DOI: 10.1016/j.jpain.2019.04.008  1
2019 Navratilova E, Patwardhan A, Porreca F. Opioid analgesics pass the acid test. Lancet (London, England). 393: 1579-1581. PMID 31007186 DOI: 10.1016/S0140-6736(19)30421-0  0.76
2019 Xie JY, Qu C, Munro G, Petersen KA, Porreca F. Antihyperalgesic effects of Meteorin in the rat chronic constriction injury (CCI) model: a replication study. Pain. PMID 30908357 DOI: 10.1097/j.pain.0000000000001569  0.72
2019 Phelps CE, Navratilova E, Dickenson AH, Porreca F, Bannister K. Kappa Opioid Signaling in the Right Central Amygdala Causes Hindpaw Specific Loss of Diffuse Noxious Inhibitory Controls (DNIC) in Experimental Neuropathic Pain. Pain. PMID 30870321 DOI: 10.1097/j.pain.0000000000001553  0.76
2019 Navratilova E, Porreca F. Substance P and Inflammatory Pain: Getting It Wrong and Right Simultaneously. Neuron. 101: 353-355. PMID 30731054 DOI: 10.1016/j.neuron.2019.01.034  0.76
2018 Navratilova E, Ji G, Phelps C, Qu C, Hein M, Yakhnitsa V, Neugebauer V, Porreca F. Kappa opioid signaling in the central nucleus of the amygdala promotes disinhibition and aversiveness of chronic neuropathic pain. Pain. PMID 30681985 DOI: 10.1097/j.pain.0000000000001458  0.76
2018 Nation KM, Dodick DW, Navratilova E, Porreca F. Sustained exposure to acute migraine medications combined with repeated noxious stimulation dysregulates descending pain modulatory circuits: Relevance to medication overuse headache. Cephalalgia : An International Journal of Headache. 333102418804157. PMID 30286616 DOI: 10.1177/0333102418804157  0.76
2018 Snyder LM, Chiang MC, Loeza-Alcocer E, Omori Y, Hachisuka J, Sheahan TD, Gale JR, Adelman PC, Sypek EI, Fulton SA, Friedman RL, Wright MC, Duque MG, Lee YS, Hu Z, ... ... Porreca F, et al. Kappa Opioid Receptor Distribution and Function in Primary Afferents. Neuron. 99: 1274-1288.e6. PMID 30236284 DOI: 10.1016/j.neuron.2018.08.044  0.64
2018 Johnstone TBC, Xie JY, Qu C, Wasiak DJ, Hogenkamp DJ, Porreca F, Gee KW. Positive Allosteric Modulators of Non-Benzodiazepine γ-Aminobutyric acida Receptor Subtypes for the Treatment of Chronic Pain. Pain. PMID 30204648 DOI: 10.1097/j.pain.0000000000001392  0.72
2018 Flores AJ, Bartlett MJ, Root BK, Parent KL, Heien ML, Porreca F, Polt R, Sherman SJ, Falk T. The combination of the opioid glycopeptide MMP-2200 and a NMDA receptor antagonist reduced l-DOPA-induced dyskinesia and MMP-2200 by itself reduced dopamine receptor 2-like agonist-induced dyskinesia. Neuropharmacology. 141: 260-271. PMID 30201210 DOI: 10.1016/j.neuropharm.2018.09.005  0.4
2018 Schiene K, Schröder W, Linz K, Frosch S, Tzschentke TM, Christoph T, Xie JY, Porreca F. Inhibition of experimental visceral pain in rodents by cebranopadol. Behavioural Pharmacology. PMID 30161034 DOI: 10.1097/FBP.0000000000000420  0.72
2018 Gomtsian L, Bannister K, Eyde N, Robles D, Dickenson AH, Porreca F, Navratilova E. Morphine effects within the rodent anterior cingulate cortex and rostral ventromedial medulla reveal separable modulation of affective and sensory qualities of acute or chronic pain. Pain. PMID 30086115 DOI: 10.1097/j.pain.0000000000001355  0.76
2018 Garami A, Ibrahim M, Gilbraith K, Khanna R, Pakai E, Miko A, Pinter E, Romanovsky AA, Porreca F, Patwardhan AM. In Reply. Anesthesiology. 129: 378-379. PMID 30020181 DOI: 10.1097/ALN.0000000000002294  0.72
2018 Patel R, Qu C, Xie JY, Porreca F, Dickenson AH. Selective deficiencies in descending inhibitory modulation in neuropathic rats: implications for enhancing noradrenergic tone. Pain. PMID 29863529 DOI: 10.1097/j.pain.0000000000001300  0.72
2018 Remesic M, Macedonio G, Mollica A, Porreca F, Hruby V, Lee YS. Cyclic biphalin analogues with a novel linker lead to potent agonist activities at mu, delta, and kappa opioid receptors. Bioorganic & Medicinal Chemistry. PMID 29858157 DOI: 10.1016/j.bmc.2018.05.045  0.64
2018 Patwardhan A, Porreca F, Schmidt WK, Romanovsky AA. The opioid crisis and … reconsidering the use of drugs that affect body temperature. Temperature (Austin, Tex.). 5: 1-3. PMID 29687038 DOI: 10.1080/23328940.2018.1437312  0.36
2018 Cowen SL, Phelps CE, Navratilova E, McKinzie DL, Okun A, Husain O, Gleason SD, Witkin JM, Porreca F. Chronic pain impairs cognitive flexibility and engages novel learning strategies in rats. Pain. PMID 29578947 DOI: 10.1097/j.pain.0000000000001226  0.76
2018 Nation KM, DeFelice M, Hernandez PI, Dodick DW, Neugebauer V, Navratilova E, Porreca F. Lateralized Kappa Opioid Receptor Signaling from the Amygdala Central Nucleus Promotes Stress-Induced Functional Pain. Pain. PMID 29369967 DOI: 10.1097/j.pain.0000000000001167  0.76
2018 Watanabe M, Narita M, Hamada Y, Yamashita A, Tamura H, Ikegami D, Kondo T, Shinzato T, Shimizu T, Fukuchi Y, Muto A, Okano H, Yamanaka A, Tawfik V, Kuzumaki N, ... ... Porreca F, et al. [EXPRESS] Activation of ventral tegmental area dopaminergic neurons reverses pathological allodynia resulting from nerve injury or bone cancer. Molecular Pain. 1744806918756406. PMID 29357732 DOI: 10.1177/1744806918756406  0.76
2018 Watanabe M, Sugiura Y, Sugiyama E, Narita M, Navratilova E, Kondo T, Uchiyama N, Yamanaka A, Kuzumaki N, Porreca F, Narita M. [EXPRESS] Extracellular N-acetylaspartylglutamate released in the nucleus accumbens modulates the pain sensation: analysis using a microdialysis/mass spectrometry integrated system. Molecular Pain. 1744806918754934. PMID 29310499 DOI: 10.1177/1744806918754934  0.76
2017 Remeniuk B, King T, Suktankhar D, Nippert A, Li N, Li F, Cheng K, Rice KC, Porreca F. Disease modifying actions of IL-6 blockade in a rat model of bone cancer pain. Pain. PMID 29300279 DOI: 10.1097/j.pain.0000000000001139  0.72
2017 Godfrey L, Iannitelli A, Garrett NL, Moger J, Imbert I, King T, Porreca F, Soundararajan R, Lalatsa A, Schätzlein AG, Uchegbu IF. Nanoparticulate peptide delivery exclusively to the brain produces tolerance free analgesia. Journal of Controlled Release : Official Journal of the Controlled Release Society. 270: 135-144. PMID 29191784 DOI: 10.1016/j.jconrel.2017.11.041  0.72
2017 Bannister K, Qu C, Navratilova E, Oyarzo J, Xie JY, King T, Dickenson AH, Porreca F. Multiple sites and actions of gabapentin-induced relief of ongoing experimental neuropathic pain. Pain. PMID 28832395 DOI: 10.1097/j.pain.0000000000001040  0.76
2017 Vardanyan RS, Cain JP, Haghighi SM, Kumirov VK, McIntosh MI, Sandweiss AJ, Porreca F, Hruby VJ. Synthesis and Investigation of Mixed μ-Opioid and δ-Opioid Agonists as Possible Bivalent Ligands for Treatment of Pain. Journal of Heterocyclic Chemistry. 54: 1228-1235. PMID 28819330 DOI: 10.1002/jhet.2696  0.92
2017 Moutal A, Yang X, Li W, Gilbraith KB, Luo S, Cai S, François-Moutal L, Chew LA, Yeon SK, Bellampalli SS, Qu C, Xie JY, Ibrahim MM, Khanna M, Park KD, ... Porreca F, et al. CRISPR/Cas9 editing of Nf1 gene identifies CRMP2 as a therapeutic target in neurofibromatosis type 1-related pain that is reversed by (S)-Lacosamide. Pain. PMID 28809766 DOI: 10.1097/j.pain.0000000000001002  0.72
2017 Garami A, Ibrahim M, Gilbraith K, Khanna R, Pakai E, Miko A, Pinter E, Romanovsky AA, Porreca F, Patwardhan AM. Transient Receptor Potential Vanilloid 1 Antagonists Prevent Anesthesia-induced Hypothermia and Decrease Postincisional Opioid Dose Requirements in Rodents. Anesthesiology. PMID 28806222 DOI: 10.1097/ALN.0000000000001812  0.72
2017 Chichorro JG, Porreca F, Sessle B. Mechanisms of craniofacial pain. Cephalalgia : An International Journal of Headache. 333102417704187. PMID 28440673 DOI: 10.1177/0333102417704187  0.4
2017 Havelin J, Imbert I, Sukhtankar D, Remeniuk B, Pelletier I, Gentry J, Okun A, Tiutan T, Porreca F, King T. Mediation of movement-induced breakthrough cancer pain by IB4 binding nociceptors in rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28438966 DOI: 10.1523/JNEUROSCI.1212-16.2017  0.72
2017 Xie JY, De Felice M, Kopruszinski CM, Eyde N, LaVigne J, Remeniuk B, Hernandez P, Yue X, Goshima N, Ossipov M, King T, Streicher JM, Navratilova E, Dodick D, Rosen H, ... ... Porreca F, et al. Kappa opioid receptor antagonists: A possible new class of therapeutics for migraine prevention. Cephalalgia : An International Journal of Headache. 333102417702120. PMID 28376659 DOI: 10.1177/0333102417702120  0.76
2017 Remesic MV, Hruby VJ, Porreca F, Lee YS. Recent Advances in the Realm of Allosteric Modulators for the Opioid Receptors for Future Therapeutics. Acs Chemical Neuroscience. PMID 28368571 DOI: 10.1021/acschemneuro.7b00090  0.92
2017 Porreca F, Navratilova E. Reward, motivation and emotion of pain and its relief. Pain. PMID 28106670 DOI: 10.1097/j.pain.0000000000000798  0.76
2017 Ibrahim MM, Patwardhan A, Gilbraith KB, Moutal A, Yang X, Chew LA, Largent-Milnes T, Malan TP, Vanderah TW, Porreca F, Khanna R. Long-lasting antinociceptive effects of green light in acute and chronic pain in rats. Pain. 158: 347-360. PMID 28092651 DOI: 10.1097/j.pain.0000000000000767  1
2016 Dearborn M, Pelletier I, Gentry J, Havelin J, Imbert I, Sukhtankar D, Remeniuk B, Porreca F, King T. (306) Pain and pain relief: using motivation to explore mechanisms underlying cancer-induced pain in rats. The Journal of Pain : Official Journal of the American Pain Society. 17: S52. PMID 28162544 DOI: 10.1016/j.jpain.2016.01.213  0.72
2016 Moutal A, Eyde N, Telemi E, Park KD, Xie JY, Dodick DW, Porreca F, Khanna R. Efficacy of (S)-Lacosamide in preclinical models of cephalic pain. Pain Reports (Baltimore, Md.). 1. PMID 27917413 DOI: 10.1097/PR9.0000000000000565  0.72
2016 Rice FL, Xie JY, Albrecht PJ, Acker E, Bourgeois J, Navratilova E, Dodick DW, Porreca F. Anatomy and immunochemical characterization of the non-arterial peptidergic diffuse dural innervation of the rat and Rhesus monkey: Implications for functional regulation and treatment in migraine. Cephalalgia : An International Journal of Headache. PMID 27852962 DOI: 10.1177/0333102416677051  0.76
2016 Ramos-Colon CN, Lee YS, Remesic MV, Hall SM, LaVigne J, Davis P, Sandweiss AJ, McIntosh MI, Hanson J, Largent-Milnes TM, Vanderah TW, Streicher JM, Porreca F, Hruby VJ. Structure Activity Relationships of [des-Arg(7)]- Dynorphin A Analogues at the Kappa Opioid Receptor. Journal of Medicinal Chemistry. PMID 27797517 DOI: 10.1021/acs.jmedchem.6b01411  1
2016 Lee YS, Remesic M, Ramos-Colon C, Hall SM, Kuzmin A, Rankin D, Porreca F, Lai J, Hruby VJ. Cyclic non-opioid dynorphin A analogues for the bradykinin receptors. Bioorganic & Medicinal Chemistry Letters. PMID 27756562 DOI: 10.1016/j.bmcl.2016.10.010  1
2016 Hall SM, LeBaron L, Ramos-Colon CN, Qu C, Xie JY, Porreca F, Lai J, Lee YS, Hruby VJ. Discovery of Stable Non-opioid Dynorphin A Analogues Interacting at the Bradykinin Receptors for the Treatment of Neuropathic Pain. Acs Chemical Neuroscience. PMID 27619237 DOI: 10.1021/acschemneuro.6b00258  1
2016 Okun A, McKinzie DL, Witkin JM, Remeniuk B, Husein O, Gleason SD, Oyarzo J, Navratilova E, McElroy B, Cowen S, Kennedy JD, Porreca F. Hedonic and motivational responses to food reward are unchanged in rats with neuropathic pain. Pain. PMID 27548047 DOI: 10.1097/j.pain.0000000000000695  0.76
2016 Xie JY, Chew LA, Yang X, Wang Y, Qu C, Wang Y, Federici LM, Fitz SD, Ripsch MS, Due MR, Moutal A, Khanna M, White FA, Vanderah TW, Johnson PL, ... Porreca F, et al. Sustained relief of ongoing experimental neuropathic pain by a CRMP2 peptide aptamer with low abuse potential. Pain. 157: 2124-2140. PMID 27537210 DOI: 10.1097/j.pain.0000000000000628  1
2016 Kopruszinski CM, Xie JY, Eyde NM, Remeniuk B, Walter S, Stratton J, Bigal M, Chichorro JG, Dodick D, Porreca F. Prevention of stress- or nitric oxide donor-induced medication overuse headache by a calcitonin gene-related peptide antibody in rodents. Cephalalgia : An International Journal of Headache. PMID 27206958 DOI: 10.1177/0333102416650702  0.72
2016 Lee YS, Kupp R, Remesic M, Ramos-Colon C, Hall SM, Chan C, Rankin D, Lai J, Porreca F, Hruby VJ. Various modifications of the amphipathic dynorphin A phamacophore for rat brain bradykinin receptors. Chemical Biology & Drug Design. PMID 27203574 DOI: 10.1111/cbdd.12789  1
2016 Moutal A, Chew LA, Yang X, Wang Y, Yeon SK, Telemi E, Meroueh S, Park KD, Shrinivasan R, Gilbraith KB, Qu C, Xie JY, Patwardhan A, Vanderah TW, Khanna M, ... Porreca F, et al. (S)-Lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology. Pain. PMID 26967696 DOI: 10.1097/j.pain.0000000000000555  1
2016 Navratilova E, Morimura K, Xie JY, Atcherley CW, Ossipov MH, Porreca F. Positive emotions and brain reward circuits in chronic pain. The Journal of Comparative Neurology. PMID 26788716 DOI: 10.1002/cne.23968  1
2016 Vardanyan RS, Cain JP, Haghighi SM, Kumirov VK, Mcintosh MI, Sandweiss AJ, Porreca F, Hruby VJ. Synthesis and Investigation of Mixed μ-Opioid and δ-Opioid Agonists as Possible Bivalent Ligands for Treatment of Pain Journal of Heterocyclic Chemistry. DOI: 10.1002/jhet.2696  1
2015 Havelin J, Imbert I, Cormier J, Allen J, Porreca F, King T. Central sensitization and neuropathic features of ongoing pain in a rat model of advanced osteoarthritis. The Journal of Pain : Official Journal of the American Pain Society. PMID 26694132 DOI: 10.1016/j.jpain.2015.12.001  1
2015 Andrews NA, Latrémolière A, Basbaum AI, Mogil JS, Porreca F, Rice AS, Woolf CJ, Currie GL, Dworkin RH, Eisenach JC, Evans S, Gewandter JS, Gover TD, Handwerker H, Huang W, et al. Ensuring transparency and minimization of methodologic bias in preclinical pain research: Pprecise considerations. Pain. PMID 26683237 DOI: 10.1097/j.pain.0000000000000458  1
2015 Navratilova E, Atcherley CW, Porreca F. Brain Circuits Encoding Reward from Pain Relief. Trends in Neurosciences. PMID 26603560 DOI: 10.1016/j.tins.2015.09.003  1
2015 Becerra L, Bishop J, Barmettler G, Xie JY, Navratilova E, Porreca F, Borsook D. Triptans Disrupt Brain Networks and Promote Stress-induced CSD-like Responses in Cortical and Subcortical Areas. Journal of Neurophysiology. jn.00632.2015. PMID 26490291 DOI: 10.1152/jn.00632.2015  1
2015 Giri AK, Apostol CR, Wang Y, Forte BL, Largent-Milnes TM, Davis P, Rankin D, Molnar G, Olson KM, Porreca F, Vanderah TW, Hruby VJ. Discovery of Novel Multifunctional Ligands with μ/δ Opioid Agonist/Neurokinin-1 (NK1) Antagonist Activities for the Treatment of Pain. Journal of Medicinal Chemistry. PMID 26465170 DOI: 10.1021/acs.jmedchem.5b01170  1
2015 Harasawa I, Johansen JP, Fields HL, Porreca F, Meng ID. Alterations in the rostral ventromedial medulla after the selective ablation of mu-opioid receptor expressing neurons. Pain. PMID 26335909 DOI: 10.1097/j.pain.0000000000000344  0.44
2015 Deekonda S, Wugalter L, Rankin D, Largent-Milnes TM, Davis P, Wang Y, Bassirirad NM, Lai J, Kulkarni V, Vanderah TW, Porreca F, Hruby VJ. Design and synthesis of novel bivalent ligands (MOR and DOR) by conjugation of enkephalin analogues with 4-anilidopiperidine derivatives. Bioorganic & Medicinal Chemistry Letters. PMID 26323872 DOI: 10.1016/j.bmcl.2015.07.064  1
2015 Deekonda S, Rankin D, Davis P, Lai J, Porreca F, Hruby VJ. Design, synthesis and biological evaluation of multifunctional ligands targeting opioid and bradykinin 2 receptors. Bioorganic & Medicinal Chemistry Letters. 25: 4148-52. PMID 26316468 DOI: 10.1016/j.bmcl.2015.08.014  1
2015 Deekonda S, Wugalter L, Kulkarni V, Rankin D, Largent-Milnes TM, Davis P, Bassirirad NM, Lai J, Vanderah TW, Porreca F, Hruby VJ. Discovery of 5-substituted tetrahydronaphthalen-2yl-methyl with N-phenyl-N-(piperidin-4-yl)propionamide derivatives as potent opioid receptor ligands. Bioorganic & Medicinal Chemistry. 23: 6185-94. PMID 26299827 DOI: 10.1016/j.bmc.2015.07.071  1
2015 Lee YS, Hall SM, Ramos-Colon C, Remesic M, Rankin D, Vanderah TW, Porreca F, Lai J, Hruby VJ. Blockade of non-opioid excitatory effects of spinal dynorphin A at bradykinin receptors. Receptors & Clinical Investigation. 2. PMID 26221618 DOI: 10.14800/rci.517  1
2015 Nair P, Yamamoto T, Cowell S, Kulkarni V, Moye S, Navratilova E, Davis P, Ma SW, Vanderah TW, Lai J, Porreca F, Hruby VJ. Discovery of tripeptide-derived multifunctional ligands possessing delta/mu opioid receptor agonist and neurokinin 1 receptor antagonist activities. Bioorganic & Medicinal Chemistry Letters. 25: 3716-20. PMID 26212775 DOI: 10.1016/j.bmcl.2015.06.030  1
2015 Remeniuk B, Sukhtankar D, Okun A, Navratilova E, Xie JY, King T, Porreca F. Behavioral and Neurochemical Analysis of Ongoing Bone Cancer Pain in Rats. Pain. PMID 25955964 DOI: 10.1097/j.pain.0000000000000218  1
2015 Navratilova E, Xie JY, Meske D, Qu C, Morimura K, Okun A, Arakawa N, Ossipov M, Fields HL, Porreca F. Endogenous opioid activity in the anterior cingulate cortex is required for relief of pain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 7264-71. PMID 25948274 DOI: 10.1523/JNEUROSCI.3862-14.2015  1
2015 Vreeland RF, Atcherley CW, Russell WS, Xie JY, Lu D, Laude ND, Porreca F, Heien ML. Biocompatible PEDOT:Nafion composite electrode coatings for selective detection of neurotransmitters in vivo. Analytical Chemistry. 87: 2600-7. PMID 25692657 DOI: 10.1021/ac502165f  1
2015 Guillemyn K, Kleczkowska P, Lesniak A, Dyniewicz J, Van der Poorten O, Van den Eynde I, Keresztes A, Varga E, Lai J, Porreca F, Chung NN, Lemieux C, Mika J, Rojewska E, Makuch W, et al. Synthesis and biological evaluation of compact, conformationally constrained bifunctional opioid agonist - neurokinin-1 antagonist peptidomimetics. European Journal of Medicinal Chemistry. 92: 64-77. PMID 25544687 DOI: 10.1016/j.ejmech.2014.12.033  1
2015 Lee YS, Hall SM, Ramos-Colon C, Remesic M, LeBaron L, Nguyen A, Rankin D, Porreca F, Lai J, Hruby VJ. Modification of amphipathic non-opioid dynorphin A analogues for rat brain bradykinin receptors. Bioorganic & Medicinal Chemistry Letters. 25: 30-3. PMID 25434001 DOI: 10.1016/j.bmcl.2014.11.026  1
2015 Little JW, Ford A, Symons-Liguori AM, Chen Z, Janes K, Doyle T, Xie J, Luongo L, Tosh DK, Maione S, Bannister K, Dickenson AH, Vanderah TW, Porreca F, Jacobson KA, et al. Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states. Brain : a Journal of Neurology. 138: 28-35. PMID 25414036 DOI: 10.1093/brain/awu330  1
2015 Deekonda S, Rankin D, Davis P, Lai J, Porreca F, Hruby VJ. Design, synthesis and biological evaluation of multifunctional ligands targeting opioid and bradykinin 2 receptors Bioorganic and Medicinal Chemistry Letters. DOI: 10.1016/j.bmcl.2015.08.014  1
2015 Deekonda S, Wugalter L, Kulkarni V, Rankin D, Largent-Milnes TM, Davis P, Bassirirad NM, Lai J, Vanderah TW, Porreca F, Hruby VJ. Discovery of 5-substituted tetrahydronaphthalen-2yl-methyl with N-phenyl-N-(piperidin-4-yl)propionamide derivatives as potent opioid receptor ligands Bioorganic and Medicinal Chemistry. 23: 6185-6194. DOI: 10.1016/j.bmc.2015.07.071  1
2014 Lee YS, Rankin D, Hall SM, Ramos-Colon C, Ortiz JJ, Kupp R, Porreca F, Lai J, Hruby VJ. Structure-activity relationships of non-opioid [des-Arg(7)]-dynorphin A analogues for bradykinin receptors. Bioorganic & Medicinal Chemistry Letters. 24: 4976-9. PMID 25282551 DOI: 10.1016/j.bmcl.2014.09.033  1
2014 Navratilova E, Porreca F. Reward and motivation in pain and pain relief. Nature Neuroscience. 17: 1304-12. PMID 25254980 DOI: 10.1038/nn.3811  1
2014 Mollica A, Carotenuto A, Novellino E, Limatola A, Costante R, Pinnen F, Stefanucci A, Pieretti S, Borsodi A, Samavati R, Zador F, Benyhe S, Davis P, Porreca F, Hruby VJ. Novel cyclic biphalin analogue with improved antinociceptive properties. Acs Medicinal Chemistry Letters. 5: 1032-6. PMID 25221662 DOI: 10.1021/ml500241n  1
2014 Dussor G, Yan J, Xie JY, Ossipov MH, Dodick DW, Porreca F. Targeting TRP channels for novel migraine therapeutics. Acs Chemical Neuroscience. 5: 1085-96. PMID 25138211 DOI: 10.1021/cn500083e  1
2014 Borsook D, Hargreaves R, Bountra C, Porreca F. Lost but making progress--Where will new analgesic drugs come from? Science Translational Medicine. 6: 249sr3. PMID 25122640 DOI: 10.1126/scitranslmed.3008320  1
2014 King T, Porreca F. Preclinical assessment of pain: improving models in discovery research. Current Topics in Behavioral Neurosciences. 20: 101-20. PMID 25012511 DOI: 10.1007/7854_2014_330  1
2014 Bannister K, Lee YS, Goncalves L, Porreca F, Lai J, Dickenson AH. Neuropathic plasticity in the opioid and non-opioid actions of dynorphin A fragments and their interactions with bradykinin B2 receptors on neuronal activity in the rat spinal cord. Neuropharmacology. 85: 375-83. PMID 24937046 DOI: 10.1016/j.neuropharm.2014.06.005  1
2014 Xie JY, Qu C, Patwardhan A, Ossipov MH, Navratilova E, Becerra L, Borsook D, Porreca F. Activation of mesocorticolimbic reward circuits for assessment of relief of ongoing pain: a potential biomarker of efficacy. Pain. 155: 1659-66. PMID 24861580 DOI: 10.1016/j.pain.2014.05.018  1
2014 Ossipov MH, Morimura K, Porreca F. Descending pain modulation and chronification of pain. Current Opinion in Supportive and Palliative Care. 8: 143-51. PMID 24752199 DOI: 10.1097/SPC.0000000000000055  1
2014 Lee YS, Muthu D, Hall SM, Ramos-Colon C, Rankin D, Hu J, Sandweiss AJ, De Felice M, Xie JY, Vanderah TW, Porreca F, Lai J, Hruby VJ. Discovery of amphipathic dynorphin A analogues to inhibit the neuroexcitatory effects of dynorphin A through bradykinin receptors in the spinal cord. Journal of the American Chemical Society. 136: 6608-16. PMID 24742335 DOI: 10.1021/ja501677q  1
2014 Wang R, Rossomando A, Sah DW, Ossipov MH, King T, Porreca F. Artemin induced functional recovery and reinnervation after partial nerve injury. Pain. 155: 476-84. PMID 24269493 DOI: 10.1016/j.pain.2013.11.007  1
2014 Mamet J, Klukinov M, Yaksh TL, Malkmus SA, Williams S, Harris S, Manning DC, Taylor BK, Donahue RR, Porreca F, Xie JY, Oyarzo J, Brennan TJ, Subieta A, Schmidt WK, et al. Single intrathecal administration of the transcription factor decoy AYX1 prevents acute and chronic pain after incisional, inflammatory, or neuropathic injury. Pain. 155: 322-33. PMID 24145208 DOI: 10.1016/j.pain.2013.10.015  1
2014 Yoshimura RF, Tran MB, Hogenkamp DJ, Johnstone TB, Xie JY, Porreca F, Gee KW. Limited central side effects of a β-subunit subtype-selective GABAA receptor allosteric modulator. Journal of Psychopharmacology (Oxford, England). 28: 472-8. PMID 24108410 DOI: 10.1177/0269881113507643  1
2014 Meske DS, Xie JY, Oyarzo J, Badghisi H, Ossipov MH, Porreca F. Opioid and noradrenergic contributions of tapentadol in experimental neuropathic pain. Neuroscience Letters. 562: 91-6. PMID 23969300 DOI: 10.1016/j.neulet.2013.08.017  1
2013 Lee YS, Qu HC, Davis P, Ma SW, Vardanyan R, Lai J, Porreca F, Hruby VJ. Chiral Effect of a Phe Residue in Position 3 of the Dmt(1)-L(or D)-Tic(2) Analogues on Opioid Functional Activities. Acs Medicinal Chemistry Letters. 4: 656-659. PMID 24648867 DOI: 10.1021/ml400115n  1
2013 Green AL, Gu P, De Felice M, Dodick D, Ossipov MH, Porreca F. Increased susceptibility to cortical spreading depression in an animal model of medication-overuse headache. Cephalalgia : An International Journal of Headache. 34: 594-604. PMID 24335852 DOI: 10.1177/0333102413515344  1
2013 Nair P, Yamamoto T, Largent-Milnes TM, Cowell S, Kulkarni V, Moye S, Navratilova E, Davis P, Ma SW, Vanderah TW, Lai J, Porreca F, Hruby VJ. Truncation of the peptide sequence in bifunctional ligands with mu and delta opioid receptor agonist and neurokinin 1 receptor antagonist activities. Bioorganic & Medicinal Chemistry Letters. 23: 4975-8. PMID 23899615 DOI: 10.1016/j.bmcl.2013.06.065  1
2013 Largent-Milnes TM, Brookshire SW, Skinner DP, Hanlon KE, Giuvelis D, Yamamoto T, Davis P, Campos CR, Nair P, Deekonda S, Bilsky EJ, Porreca F, Hruby VJ, Vanderah TW. Building a better analgesic: multifunctional compounds that address injury-induced pathology to enhance analgesic efficacy while eliminating unwanted side effects. The Journal of Pharmacology and Experimental Therapeutics. 347: 7-19. PMID 23860305 DOI: 10.1124/jpet.113.205245  1
2013 Becerra L, Navratilova E, Porreca F, Borsook D. Analogous responses in the nucleus accumbens and cingulate cortex to pain onset (aversion) and offset (relief) in rats and humans. Journal of Neurophysiology. 110: 1221-6. PMID 23785130 DOI: 10.1152/jn.00284.2013  1
2013 De Felice M, Eyde N, Dodick D, Dussor GO, Ossipov MH, Fields HL, Porreca F. Capturing the aversive state of cephalic pain preclinically. Annals of Neurology. 74: 257-65. PMID 23686557 DOI: 10.1002/ana.23922  1
2013 Stahl SM, Porreca F, Taylor CP, Cheung R, Thorpe AJ, Clair A. The diverse therapeutic actions of pregabalin: is a single mechanism responsible for several pharmacological activities? Trends in Pharmacological Sciences. 34: 332-9. PMID 23642658 DOI: 10.1016/j.tips.2013.04.001  1
2013 Petrov RR, Lee YS, Vardanyan RS, Liu L, Ma SW, Davis P, Lai J, Porreca F, Vanderah TW, Hruby VJ. Effect of anchoring 4-anilidopiperidines to opioid peptides. Bioorganic & Medicinal Chemistry Letters. 23: 3434-7. PMID 23623418 DOI: 10.1016/j.bmcl.2013.03.065  1
2013 Wang R, King T, De Felice M, Guo W, Ossipov MH, Porreca F. Descending facilitation maintains long-term spontaneous neuropathic pain. The Journal of Pain : Official Journal of the American Pain Society. 14: 845-53. PMID 23602267 DOI: 10.1016/j.jpain.2013.02.011  1
2013 Mollica A, Pinnen F, Costante R, Locatelli M, Stefanucci A, Pieretti S, Davis P, Lai J, Rankin D, Porreca F, Hruby VJ. Biological active analogues of the opioid peptide biphalin: mixed α/β(3)-peptides. Journal of Medicinal Chemistry. 56: 3419-23. PMID 23547584 DOI: 10.1021/jm301456c  1
2013 Sui P, Watanabe H, Ossipov MH, Porreca F, Bakalkin G, Bergquist J, Artemenko K. Dimethyl-labeling-based protein quantification and pathway search: a novel method of spinal cord analysis applicable for neurological studies. Journal of Proteome Research. 12: 2245-52. PMID 23520997 DOI: 10.1021/pr4001064  1
2013 Navratilova E, Xie JY, King T, Porreca F. Evaluation of reward from pain relief. Annals of the New York Academy of Sciences. 1282: 1-11. PMID 23496247 DOI: 10.1111/nyas.12095  1
2013 Taylor R, Pergolizzi JV, Porreca F, Raffa RB. Opioid antagonists for pain. Expert Opinion On Investigational Drugs. 22: 517-25. PMID 23484859 DOI: 10.1517/13543784.2013.778973  1
2013 Lozano-Ondoua AN, Hanlon KE, Symons-Liguori AM, Largent-Milnes TM, Havelin JJ, Ferland HL, Chandramouli A, Owusu-Ankomah M, Nikolich-Zugich T, Bloom AP, Jimenez-Andrade JM, King T, Porreca F, Nelson MA, Mantyh PW, et al. Disease modification of breast cancer-induced bone remodeling by cannabinoid 2 receptor agonists. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 28: 92-107. PMID 22903605 DOI: 10.1002/jbmr.1732  1
2012 Navratilova E, Xie JY, Okun A, Qu C, Eyde N, Ci S, Ossipov MH, King T, Fields HL, Porreca F. Pain relief produces negative reinforcement through activation of mesolimbic reward-valuation circuitry. Proceedings of the National Academy of Sciences of the United States of America. 109: 20709-13. PMID 23184995 DOI: 10.1073/pnas.1214605109  1
2012 Porreca F. Holiday message from Life Sciences. Life Sciences. 91: 1139. PMID 23063667 DOI: 10.1016/j.lfs.2012.10.001  1
2012 Mollica A, Pinnen F, Stefanucci A, Mannina L, Sobolev AP, Lucente G, Davis P, Lai J, Ma SW, Porreca F, Hruby VJ. cis-4-amino-L-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues: part 2. Journal of Medicinal Chemistry. 55: 8477-82. PMID 22966938 DOI: 10.1021/jm300947s  1
2012 Little JW, Chen Z, Doyle T, Porreca F, Ghaffari M, Bryant L, Neumann WL, Salvemini D. Supraspinal peroxynitrite modulates pain signaling by suppressing the endogenous opioid pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 10797-808. PMID 22875915 DOI: 10.1523/JNEUROSCI.6345-11.2012  1
2012 Annedi SC, Maddaford SP, Ramnauth J, Renton P, Rybak T, Silverman S, Rakhit S, Mladenova G, Dove P, Andrews JS, Zhang D, Porreca F. Discovery of a potent, orally bioavailable and highly selective human neuronal nitric oxide synthase (nNOS) inhibitor, N-(1-(piperidin-4-yl)indolin-5-yl)thiophene-2-carboximidamide as a pre-clinical development candidate for the treatment of migraine. European Journal of Medicinal Chemistry. 55: 94-107. PMID 22840695 DOI: 10.1016/j.ejmech.2012.07.006  1
2012 Edelmayer RM, Le LN, Yan J, Wei X, Nassini R, Materazzi S, Preti D, Appendino G, Geppetti P, Dodick DW, Vanderah TW, Porreca F, Dussor G. Activation of TRPA1 on dural afferents: a potential mechanism of headache pain. Pain. 153: 1949-58. PMID 22809691 DOI: 10.1016/j.pain.2012.06.012  1
2012 De Felice M, Melchiorri P, Ossipov MH, Vanderah TW, Porreca F, Negri L. Mechanisms of Bv8-induced biphasic hyperalgesia: increased excitatory transmitter release and expression. Neuroscience Letters. 521: 40-5. PMID 22641053 DOI: 10.1016/j.neulet.2012.05.055  1
2012 He Y, Tian X, Hu X, Porreca F, Wang ZJ. Negative reinforcement reveals non-evoked ongoing pain in mice with tissue or nerve injury. The Journal of Pain : Official Journal of the American Pain Society. 13: 598-607. PMID 22609247 DOI: 10.1016/j.jpain.2012.03.011  1
2012 Pajouhesh H, Feng ZP, Zhang L, Pajouhesh H, Jiang X, Hendricson A, Dong H, Tringham E, Ding Y, Vanderah TW, Porreca F, Belardetti F, Zamponi GW, Mitscher LA, Snutch TP. Structure-activity relationships of trimethoxybenzyl piperazine N-type calcium channel inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 4153-8. PMID 22579422 DOI: 10.1016/j.bmcl.2012.04.054  1
2012 Hughes JP, Chessell I, Malamut R, Perkins M, Bačkonja M, Baron R, Farrar JT, Field MJ, Gereau RW, Gilron I, McMahon SB, Porreca F, Rappaport BA, Rice F, Richman LK, et al. Understanding chronic inflammatory and neuropathic pain. Annals of the New York Academy of Sciences. 1255: 30-44. PMID 22564068 DOI: 10.1111/j.1749-6632.2012.06561.x  1
2012 King T, Qu C, Okun A, Melemedjian OK, Mandell EK, Maskaykina IY, Navratilova E, Dussor GO, Ghosh S, Price TJ, Porreca F. Contribution of PKMζ-dependent and independent amplification to components of experimental neuropathic pain. Pain. 153: 1263-73. PMID 22482911 DOI: 10.1016/j.pain.2012.03.006  1
2012 Mladenova G, Annedi SC, Ramnauth J, Maddaford SP, Rakhit S, Andrews JS, Zhang D, Porreca F. First-in-class, dual-action, 3,5-disubstituted indole derivatives having human nitric oxide synthase (nNOS) and norepinephrine reuptake inhibitory (NERI) activity for the treatment of neuropathic pain. Journal of Medicinal Chemistry. 55: 3488-501. PMID 22420844 DOI: 10.1021/jm300138g  1
2012 Mollica A, Pinnen F, Stefanucci A, Feliciani F, Campestre C, Mannina L, Sobolev AP, Lucente G, Davis P, Lai J, Ma SW, Porreca F, Hruby VJ. The cis-4-amino-L-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues. Journal of Medicinal Chemistry. 55: 3027-35. PMID 22394120 DOI: 10.1021/jm201402v  1
2012 Okun A, Liu P, Davis P, Ren J, Remeniuk B, Brion T, Ossipov MH, Xie J, Dussor GO, King T, Porreca F. Afferent drive elicits ongoing pain in a model of advanced osteoarthritis. Pain. 153: 924-33. PMID 22387095 DOI: 10.1016/j.pain.2012.01.022  1
2012 Annedi SC, Ramnauth J, Cossette M, Maddaford SP, Dove P, Rakhit S, Andrews JS, Porreca F. Novel, druglike 1,7-disubstituted 2,3,4,5-tetrahydro-1H-benzo[b]azepine-based selective inhibitors of human neuronal nitric oxide synthase (nNOS). Bioorganic & Medicinal Chemistry Letters. 22: 2510-3. PMID 22370270 DOI: 10.1016/j.bmcl.2012.02.004  1
2012 Edelmayer RM, Ossipov MH, Porreca F. An experimental model of headache-related pain. Methods in Molecular Biology (Clifton, N.J.). 851: 109-20. PMID 22351085 DOI: 10.1007/978-1-61779-561-9_7  1
2012 Ramnauth J, Renton P, Dove P, Annedi SC, Speed J, Silverman S, Mladenova G, Maddaford SP, Zinghini S, Rakhit S, Andrews J, Lee DK, Zhang D, Porreca F. 1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors: lead optimization studies resulting in the identification of N-(1-(2-(methylamino)ethyl)-1,2,3,4-tetrahydroquinolin-6-yl)thiophene-2-carboximidamide as a preclinical development candidate. Journal of Medicinal Chemistry. 55: 2882-93. PMID 22335555 DOI: 10.1021/jm3000449  1
2012 Annedi SC, Maddaford SP, Ramnauth J, Renton P, Speed J, Rakhit S, Andrews JS, Porreca F. 3,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase (nNOS) inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 1980-4. PMID 22318159 DOI: 10.1016/j.bmcl.2012.01.031  1
2012 Amrutkar DV, Ploug KB, Hay-Schmidt A, Porreca F, Olesen J, Jansen-Olesen I. mRNA expression of 5-hydroxytryptamine 1B, 1D, and 1F receptors and their role in controlling the release of calcitonin gene-related peptide in the rat trigeminovascular system. Pain. 153: 830-8. PMID 22305629 DOI: 10.1016/j.pain.2012.01.005  1
2012 Annedi SC, Ramnauth J, Maddaford SP, Renton P, Rakhit S, Mladenova G, Dove P, Silverman S, Andrews JS, Felice MD, Porreca F. Discovery of cis-N-(1-(4-(methylamino)cyclohexyl)indolin-6-yl)thiophene-2-carboximidamide: a 1,6-disubstituted indoline derivative as a highly selective inhibitor of human neuronal nitric oxide synthase (nNOS) without any cardiovascular liabilities. Journal of Medicinal Chemistry. 55: 943-55. PMID 22175766 DOI: 10.1021/jm201564u  1
2012 Lattanzi R, Sacerdote P, Franchi S, Canestrelli M, Miele R, Barra D, Visentin S, DeNuccio C, Porreca F, De Felice M, Guida F, Luongo L, de Novellis V, Maione S, Negri L. Pharmacological activity of a Bv8 analogue modified in position 24. British Journal of Pharmacology. 166: 950-63. PMID 22122547 DOI: 10.1111/j.1476-5381.2011.01797.x  1
2012 Nassini R, Materazzi S, Vriens J, Prenen J, Benemei S, De Siena G, la Marca G, Andrè E, Preti D, Avonto C, Sadofsky L, Di Marzo V, De Petrocellis L, Dussor G, Porreca F, et al. The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system. Brain : a Journal of Neurology. 135: 376-90. PMID 22036959 DOI: 10.1093/brain/awr272  1
2012 Marshall TM, Herman DS, Largent-Milnes TM, Badghisi H, Zuber K, Holt SC, Lai J, Porreca F, Vanderah TW. Activation of descending pain-facilitatory pathways from the rostral ventromedial medulla by cholecystokinin elicits release of prostaglandin-Eâ‚‚ in the spinal cord. Pain. 153: 86-94. PMID 22030324 DOI: 10.1016/j.pain.2011.09.021  1
2012 King T, Porreca F. Foreword: Analgesics for cancer pain Analgesics For Cancer Pain. 3-4. DOI: 10.2217/EBO.11.387  1
2011 Sukhtankar D, Okun A, Chandramouli A, Nelson MA, Vanderah TW, Cress AE, Porreca F, King T. Inhibition of p38-MAPK signaling pathway attenuates breast cancer induced bone pain and disease progression in a murine model of cancer-induced bone pain. Molecular Pain. 7: 81. PMID 22014040 DOI: 10.1186/1744-8069-7-81  1
2011 De Caterina R, Griffioen AW, Porreca F. Fraud in biomedical research--the role of journal editors. Life Sciences. 89: 755-6. PMID 21983417 DOI: 10.1016/j.lfs.2011.09.016  1
2011 De Caterina R, Griffioen AW, Porreca F. Fraud in biomedical research - the role of journal Editors. Vascular Pharmacology. 55: 119-20. PMID 21983415 DOI: 10.1016/j.vph.2011.09.004  1
2011 Vardanyan R, Kumirov VK, Nichol GS, Davis P, Liktor-Busa E, Rankin D, Varga E, Vanderah T, Porreca F, Lai J, Hruby VJ. Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligands. Bioorganic & Medicinal Chemistry. 19: 6135-42. PMID 21925887 DOI: 10.1016/j.bmc.2011.08.027  1
2011 Annedi SC, Maddaford SP, Mladenova G, Ramnauth J, Rakhit S, Andrews JS, Lee DK, Zhang D, Porreca F, Bunton D, Christie L. Discovery of N-(3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-6-yl) thiophene-2-carboximidamide as a selective inhibitor of human neuronal nitric oxide synthase (nNOS) for the treatment of pain. Journal of Medicinal Chemistry. 54: 7408-16. PMID 21923116 DOI: 10.1021/jm201063u  1
2011 Yue X, Falk T, Zuniga LA, Szabò L, Porreca F, Polt R, Sherman SJ. Effects of the novel glycopeptide opioid agonist MMP-2200 in preclinical models of Parkinson's disease. Brain Research. 1413: 72-83. PMID 21840512 DOI: 10.1016/j.brainres.2011.07.038  1
2011 Maddaford S, Renton P, Speed J, Annedi SC, Ramnauth J, Rakhit S, Andrews J, Mladenova G, Majuta L, Porreca F. 1,6-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors. Bioorganic & Medicinal Chemistry Letters. 21: 5234-8. PMID 21824773 DOI: 10.1016/j.bmcl.2011.07.042  1
2011 De Felice M, Sanoja R, Wang R, Vera-Portocarrero L, Oyarzo J, King T, Ossipov MH, Vanderah TW, Lai J, Dussor GO, Fields HL, Price TJ, Porreca F. Engagement of descending inhibition from the rostral ventromedial medulla protects against chronic neuropathic pain. Pain. 152: 2701-9. PMID 21745713 DOI: 10.1016/j.pain.2011.06.008  1
2011 Fioravanti B, Kasasbeh A, Edelmayer R, Skinner DP, Hartings JA, Burklund RD, De Felice M, French ED, Dussor GO, Dodick DW, Porreca F, Vanderah TW. Evaluation of cutaneous allodynia following induction of cortical spreading depression in freely moving rats. Cephalalgia : An International Journal of Headache. 31: 1090-100. PMID 21700643 DOI: 10.1177/0333102411410609  1
2011 Ramnauth J, Speed J, Maddaford SP, Dove P, Annedi SC, Renton P, Rakhit S, Andrews J, Silverman S, Mladenova G, Zinghini S, Nair S, Catalano C, Lee DK, De Felice M, ... Porreca F, et al. Design, synthesis, and biological evaluation of 3,4-dihydroquinolin-2(1H)-one and 1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors. Journal of Medicinal Chemistry. 54: 5562-75. PMID 21699209 DOI: 10.1021/jm200648s  1
2011 King T, Qu C, Okun A, Mercado R, Ren J, Brion T, Lai J, Porreca F. Contribution of afferent pathways to nerve injury-induced spontaneous pain and evoked hypersensitivity. Pain. 152: 1997-2005. PMID 21620567 DOI: 10.1016/j.pain.2011.04.020  1
2011 Bannister K, Sikandar S, Bauer CS, Dolphin AC, Porreca F, Dickenson AH. Pregabalin suppresses spinal neuronal hyperexcitability and visceral hypersensitivity in the absence of peripheral pathophysiology. Anesthesiology. 115: 144-52. PMID 21602662 DOI: 10.1097/ALN.0b013e31821f6545  1
2011 Hanlon KE, Herman DS, Agnes RS, Largent-Milnes TM, Kumarasinghe IR, Ma SW, Guo W, Lee YS, Ossipov MH, Hruby VJ, Lai J, Porreca F, Vanderah TW. Novel peptide ligands with dual acting pharmacophores designed for the pathophysiology of neuropathic pain. Brain Research. 1395: 1-11. PMID 21550594 DOI: 10.1016/j.brainres.2011.04.024  1
2011 Asiedu MN, Tillu DV, Melemedjian OK, Shy A, Sanoja R, Bodell B, Ghosh S, Porreca F, Price TJ. Spinal protein kinase M ζ underlies the maintenance mechanism of persistent nociceptive sensitization. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 6646-53. PMID 21543593 DOI: 10.1523/JNEUROSCI.6286-10.2011  1
2011 Qu C, King T, Okun A, Lai J, Fields HL, Porreca F. Lesion of the rostral anterior cingulate cortex eliminates the aversiveness of spontaneous neuropathic pain following partial or complete axotomy. Pain. 152: 1641-8. PMID 21474245 DOI: 10.1016/j.pain.2011.03.002  1
2011 De Felice M, Ossipov MH, Porreca F. Persistent medication-induced neural adaptations, descending facilitation, and medication overuse headache. Current Opinion in Neurology. 24: 193-6. PMID 21467931 DOI: 10.1097/WCO.0b013e328346af25  1
2011 Meng ID, Dodick D, Ossipov MH, Porreca F. Pathophysiology of medication overuse headache: insights and hypotheses from preclinical studies. Cephalalgia : An International Journal of Headache. 31: 851-60. PMID 21444643 DOI: 10.1177/0333102411402367  1
2011 Ballet S, Feytens D, Buysse K, Chung NN, Lemieux C, Tumati S, Keresztes A, Van Duppen J, Lai J, Varga E, Porreca F, Schiller PW, Vanden Broeck J, Tourwé D. Design of novel neurokinin 1 receptor antagonists based on conformationally constrained aromatic amino acids and discovery of a potent chimeric opioid agonist-neurokinin 1 receptor antagonist. Journal of Medicinal Chemistry. 54: 2467-76. PMID 21413804 DOI: 10.1021/jm1016285  1
2011 Stagg NJ, Mata HP, Ibrahim MM, Henriksen EJ, Porreca F, Vanderah TW, Philip Malan T. Regular exercise reverses sensory hypersensitivity in a rat neuropathic pain model: role of endogenous opioids. Anesthesiology. 114: 940-8. PMID 21386701 DOI: 10.1097/ALN.0b013e318210f880  1
2011 Yamamoto T, Nair P, Largent-Milnes TM, Jacobsen NE, Davis P, Ma SW, Yamamura HI, Vanderah TW, Porreca F, Lai J, Hruby VJ. Discovery of a potent and efficacious peptide derivative for δ/μ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies. Journal of Medicinal Chemistry. 54: 2029-38. PMID 21366266 DOI: 10.1021/jm101023r  1
2011 Vera-Portocarrero LP, Ossipov MH, Lai J, King T, Porreca F. Descending facilitatory pathways from the rostroventromedial medulla mediate naloxone-precipitated withdrawal in morphine-dependent rats. The Journal of Pain : Official Journal of the American Pain Society. 12: 667-76. PMID 21354865 DOI: 10.1016/j.jpain.2010.12.007  1
2011 Hildebrand ME, Smith PL, Bladen C, Eduljee C, Xie JY, Chen L, Fee-Maki M, Doering CJ, Mezeyova J, Zhu Y, Belardetti F, Pajouhesh H, Parker D, Arneric SP, Parmar M, ... Porreca F, et al. A novel slow-inactivation-specific ion channel modulator attenuates neuropathic pain. Pain. 152: 833-43. PMID 21349638 DOI: 10.1016/j.pain.2010.12.035  1
2011 Liu P, Okun A, Ren J, Guo RC, Ossipov MH, Xie J, King T, Porreca F. Ongoing pain in the MIA model of osteoarthritis. Neuroscience Letters. 493: 72-5. PMID 21241772 DOI: 10.1016/j.neulet.2011.01.027  1
2011 Okun A, DeFelice M, Eyde N, Ren J, Mercado R, King T, Porreca F. Transient inflammation-induced ongoing pain is driven by TRPV1 sensitive afferents. Molecular Pain. 7: 4. PMID 21219650 DOI: 10.1186/1744-8069-7-4  1
2011 Lee YS, Kulkarani V, Cowell SM, Ma SW, Davis P, Hanlon KE, Vanderah TW, Lai J, Porreca F, Vardanyan R, Hruby VJ. Development of potent μ and δ opioid agonists with high lipophilicity. Journal of Medicinal Chemistry. 54: 382-6. PMID 21128594 DOI: 10.1021/jm100982d  1
2011 De Felice M, Ossipov MH, Porreca F. Update on medication-overuse headache. Current Pain and Headache Reports. 15: 79-83. PMID 21058047 DOI: 10.1007/s11916-010-0155-1  1
2011 Yan J, Edelmayer RM, Wei X, De Felice M, Porreca F, Dussor G. Dural afferents express acid-sensing ion channels: a role for decreased meningeal pH in migraine headache. Pain. 152: 106-13. PMID 20971560 DOI: 10.1016/j.pain.2010.09.036  1
2011 Mollica A, Pinnen F, Feliciani F, Stefanucci A, Lucente G, Davis P, Porreca F, Ma SW, Lai J, Hruby VJ. New potent biphalin analogues containing p-fluoro-L-phenylalanine at the 4,4' positions and non-hydrazine linkers. Amino Acids. 40: 1503-11. PMID 20924622 DOI: 10.1007/s00726-010-0760-7  1
2010 Ossipov MH, Dussor GO, Porreca F. Central modulation of pain. The Journal of Clinical Investigation. 120: 3779-87. PMID 21041960 DOI: 10.1172/JCI43766  1
2010 Largent-Milnes TM, Yamamoto T, Nair P, Moulton JW, Hruby VJ, Lai J, Porreca F, Vanderah TW. Spinal or systemic TY005, a peptidic opioid agonist/neurokinin 1 antagonist, attenuates pain with reduced tolerance. British Journal of Pharmacology. 161: 986-1001. PMID 20977451 DOI: 10.1111/j.1476-5381.2010.00824.x  1
2010 Weinreb PH, Wen D, Qian F, Wildes CP, Garber EA, Walus L, Jung MY, Wang J, Relton JK, Amatucci J, Wang R, Porreca F, Silvian L, Meier W, Pepinsky RB, et al. Resolution of disulfide heterogeneity in Nogo receptor I fusion proteins by molecular engineering. Biotechnology and Applied Biochemistry. 57: 31-45. PMID 20815818 DOI: 10.1042/BA20100061  1
2010 Lian B, Vera-Portocarrero L, King T, Ossipov MH, Porreca F. Opioid-induced latent sensitization in a model of non-inflammatory viscerosomatic hypersensitivity. Brain Research. 1358: 64-70. PMID 20727859 DOI: 10.1016/j.brainres.2010.08.032  1
2010 Giordano C, Sansone A, Masi A, Lucente G, Punzi P, Mollica A, Pinnen F, Feliciani F, Cacciatore I, Davis P, Lai J, Ma SW, Porreca F, Hruby V. Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2. European Journal of Medicinal Chemistry. 45: 4594-600. PMID 20692738 DOI: 10.1016/j.ejmech.2010.07.022  1
2010 De Felice M, Ossipov MH, Wang R, Dussor G, Lai J, Meng ID, Chichorro J, Andrews JS, Rakhit S, Maddaford S, Dodick D, Porreca F. Triptan-induced enhancement of neuronal nitric oxide synthase in trigeminal ganglion dural afferents underlies increased responsiveness to potential migraine triggers. Brain : a Journal of Neurology. 133: 2475-88. PMID 20627971 DOI: 10.1093/brain/awq159  1
2010 Yamamoto T, Nair P, Jacobsen NE, Kulkarni V, Davis P, Ma SW, Navratilova E, Yamamura HI, Vanderah TW, Porreca F, Lai J, Hruby VJ. Biological and conformational evaluation of bifunctional compounds for opioid receptor agonists and neurokinin 1 receptor antagonists possessing two penicillamines. Journal of Medicinal Chemistry. 53: 5491-501. PMID 20617791 DOI: 10.1021/jm100157m  1
2010 Vardanyan M, Melemedjian OK, Price TJ, Ossipov MH, Lai J, Roberts E, Boos TL, Deschamps JR, Jacobson AE, Rice KC, Porreca F. Reversal of pancreatitis-induced pain by an orally available, small molecule interleukin-6 receptor antagonist. Pain. 151: 257-65. PMID 20599324 DOI: 10.1016/j.pain.2010.05.022  1
2010 Lee YS, Fernandes S, Kulkarani V, Mayorov A, Davis P, Ma SW, Brown K, Gillies RJ, Lai J, Porreca F, Hruby VJ. Design and synthesis of trivalent ligands targeting opioid, cholecystokinin, and melanocortin receptors for the treatment of pain. Bioorganic & Medicinal Chemistry Letters. 20: 4080-4. PMID 20547453 DOI: 10.1016/j.bmcl.2010.05.078  1
2010 Chen Q, Vera-Portocarrero LP, Ossipov MH, Vardanyan M, Lai J, Porreca F. Attenuation of persistent experimental pancreatitis pain by a bradykinin b2 receptor antagonist. Pancreas. 39: 1220-5. PMID 20531238 DOI: 10.1097/MPA.0b013e3181df1c90  1
2010 Torino D, Mollica A, Pinnen F, Feliciani F, Lucente G, Fabrizi G, Portalone G, Davis P, Lai J, Ma SW, Porreca F, Hruby VJ. Synthesis and evaluation of new endomorphin-2 analogues containing (Z)-alpha,beta-didehydrophenylalanine (Delta(Z)Phe) residues. Journal of Medicinal Chemistry. 53: 4550-4. PMID 20476738 DOI: 10.1021/jm1001343  1
2010 De Felice M, Ossipov MH, Wang R, Lai J, Chichorro J, Meng I, Dodick DW, Vanderah TW, Dussor G, Porreca F. Triptan-induced latent sensitization: a possible basis for medication overuse headache. Annals of Neurology. 67: 325-37. PMID 20373344 DOI: 10.1002/ana.21897  1
2010 Pajouhesh H, Feng ZP, Ding Y, Zhang L, Pajouhesh H, Morrison JL, Belardetti F, Tringham E, Simonson E, Vanderah TW, Porreca F, Zamponi GW, Mitscher LA, Snutch TP. Structure-activity relationships of diphenylpiperazine N-type calcium channel inhibitors. Bioorganic & Medicinal Chemistry Letters. 20: 1378-83. PMID 20117000 DOI: 10.1016/j.bmcl.2010.01.008  1
2010 Ossipov MH, Porreca F. Neuropathic Pain: Basic Mechanisms (Animal) The Senses: a Comprehensive Reference. 5: 833-855. DOI: 10.1016/B978-012370880-9.00200-0  1
2009 Sroka IC, Pond GD, Nagle RB, Porreca F, King T, Pestano G, Futscher BW, Gard JM, Riley J, Cress AE. Human Cell Surface Receptors as Molecular Imaging Candidates for Metastatic Prostate Cancer. The Open Prostate Cancer Journal. 2: 59-66. PMID 22081777 DOI: 10.2174/1876822900902010059  0.72
2009 Yamamoto T, Nair P, Jacobsen NE, Vagner J, Kulkarni V, Davis P, Ma SW, Navratilova E, Yamamura HI, Vanderah TW, Porreca F, Lai J, Hruby VJ. Improving metabolic stability by glycosylation: bifunctional peptide derivatives that are opioid receptor agonists and neurokinin 1 receptor antagonists. Journal of Medicinal Chemistry. 52: 5164-75. PMID 20560643 DOI: 10.1021/jm900473p  1
2009 Okada-Ogawa A, Porreca F, Meng ID. Sustained morphine-induced sensitization and loss of diffuse noxious inhibitory controls in dura-sensitive medullary dorsal horn neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 15828-35. PMID 20016098 DOI: 10.1523/JNEUROSCI.3623-09.2009  1
2009 King T, Vera-Portocarrero L, Gutierrez T, Vanderah TW, Dussor G, Lai J, Fields HL, Porreca F. Unmasking the tonic-aversive state in neuropathic pain. Nature Neuroscience. 12: 1364-6. PMID 19783992 DOI: 10.1038/nn.2407  1
2009 Yamamoto T, Nair P, Ma SW, Davis P, Yamamura HI, Vanderah TW, Porreca F, Lai J, Hruby VJ. The biological activity and metabolic stability of peptidic bifunctional compounds that are opioid receptor agonists and neurokinin-1 receptor antagonists with a cystine moiety. Bioorganic & Medicinal Chemistry. 17: 7337-43. PMID 19762245 DOI: 10.1016/j.bmc.2009.08.035  1
2009 Roberts J, Ossipov MH, Porreca F. Glial activation in the rostroventromedial medulla promotes descending facilitation to mediate inflammatory hypersensitivity. The European Journal of Neuroscience. 30: 229-41. PMID 19614984 DOI: 10.1111/j.1460-9568.2009.06813.x  1
2009 Torino D, Mollica A, Pinnen F, Lucente G, Feliciani F, Davis P, Lai J, Ma SW, Porreca F, Hruby VJ. Synthesis and evaluation of new endomorphin analogues modified at the Pro(2) residue. Bioorganic & Medicinal Chemistry Letters. 19: 4115-8. PMID 19560919 DOI: 10.1016/j.bmcl.2009.06.008  1
2009 Vardanyan R, Vijay G, Nichol GS, Liu L, Kumarasinghe I, Davis P, Vanderah T, Porreca F, Lai J, Hruby VJ. Synthesis and investigations of double-pharmacophore ligands for treatment of chronic and neuropathic pain. Bioorganic & Medicinal Chemistry. 17: 5044-53. PMID 19540763 DOI: 10.1016/j.bmc.2009.05.065  1
2009 De Felice M, Porreca F. Opiate-induced persistent pronociceptive trigeminal neural adaptations: potential relevance to opiate-induced medication overuse headache. Cephalalgia : An International Journal of Headache. 29: 1277-84. PMID 19438917 DOI: 10.1111/j.1468-2982.2009.01873.x  1
2009 Dogrul A, Ossipov MH, Porreca F. Differential mediation of descending pain facilitation and inhibition by spinal 5HT-3 and 5HT-7 receptors. Brain Research. 1280: 52-9. PMID 19427839 DOI: 10.1016/j.brainres.2009.05.001  1
2009 Nair P, Yamamoto T, Kulkarni V, Moye S, Navratilova E, Davis P, Largent T, Ma SW, Yamamura HI, Vanderah T, Lai J, Porreca F, Hruby VJ. Novel bifunctional peptides as opioid agonists and NK-1 antagonists. Advances in Experimental Medicine and Biology. 611: 537-8. PMID 19400302 DOI: 10.1007/978-0-387-73657-0_235  1
2009 Lee Y, Petrov R, Kulkarni V, Min BJ, Ma SW, Davis P, Oyarzo J, Vanderah T, Lai J, Porreca F, Vardanyan R, Hruby VJ. Development of mu/delta opioid ligands: enkephalin analogues containing 4-anilidopiperidine moiety. Advances in Experimental Medicine and Biology. 611: 517-8. PMID 19400292 DOI: 10.1007/978-0-387-73657-0_225  1
2009 Kulkarni VV, Lee YS, Salibay C, Davis P, Ma SW, Porreca F, Hruby VJ. Novel analogues of bifunctional ligands for opioid and melanocortin 4 receptor. Advances in Experimental Medicine and Biology. 611: 195-6. PMID 19400157 DOI: 10.1007/978-0-387-73657-0_90  1
2009 Porreca F, Ossipov MH. Nausea and vomiting side effects with opioid analgesics during treatment of chronic pain: mechanisms, implications, and management options. Pain Medicine (Malden, Mass.). 10: 654-62. PMID 19302436 DOI: 10.1111/j.1526-4637.2009.00583.x  1
2009 Edelmayer RM, Vanderah TW, Majuta L, Zhang ET, Fioravanti B, De Felice M, Chichorro JG, Ossipov MH, King T, Lai J, Kori SH, Nelsen AC, Cannon KE, Heinricher MM, Porreca F. Medullary pain facilitating neurons mediate allodynia in headache-related pain. Annals of Neurology. 65: 184-93. PMID 19259966 DOI: 10.1002/ana.21537  1
2009 Rivat C, Vera-Portocarrero LP, Ibrahim MM, Mata HP, Stagg NJ, De Felice M, Porreca F, Malan TP. Spinal NK-1 receptor-expressing neurons and descending pathways support fentanyl-induced pain hypersensitivity in a rat model of postoperative pain. The European Journal of Neuroscience. 29: 727-37. PMID 19200067 DOI: 10.1111/j.1460-9568.2009.06616.x  1
2009 Porreca F, Vanderah TW. Spring pain research conference 2008. Brain Research Reviews. 60: 1. PMID 19150467 DOI: 10.1016/j.brainresrev.2008.12.022  1
2009 Zhang W, Gardell S, Zhang D, Xie JY, Agnes RS, Badghisi H, Hruby VJ, Rance N, Ossipov MH, Vanderah TW, Porreca F, Lai J. Neuropathic pain is maintained by brainstem neurons co-expressing opioid and cholecystokinin receptors. Brain : a Journal of Neurology. 132: 778-87. PMID 19050032 DOI: 10.1093/brain/awn330  1
2009 Vardanyan A, Wang R, Vanderah TW, Ossipov MH, Lai J, Porreca F, King T. TRPV1 receptor in expression of opioid-induced hyperalgesia. The Journal of Pain : Official Journal of the American Pain Society. 10: 243-52. PMID 18774343 DOI: 10.1016/j.jpain.2008.07.004  1
2009 Basbaum AI, Braz J, Ossipov MH, Porreca F. The Endogenous Neuromodulation System Neuromodulation. 1: 303-312. DOI: 10.1016/B978-0-12-374248-3.00023-9  1
2009 Lai J, Wang R, Porreca F. Spinal dynorphin and neuropathic pain Synaptic Plasticity in Pain. 353-366. DOI: 10.1007/978-1-4419-0226-9_16  1
2008 Fioravanti B, De Felice M, Stucky CL, Medler KA, Luo MC, Gardell LR, Ibrahim M, Malan TP, Yamamura HI, Ossipov MH, King T, Lai J, Porreca F, Vanderah TW. Constitutive activity at the cannabinoid CB1 receptor is required for behavioral response to noxious chemical stimulation of TRPV1: antinociceptive actions of CB1 inverse agonists. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 11593-602. PMID 18987195 DOI: 10.1523/JNEUROSCI.3322-08.2008  1
2008 Luo MC, Chen Q, Ossipov MH, Rankin DR, Porreca F, Lai J. Spinal dynorphin and bradykinin receptors maintain inflammatory hyperalgesia. The Journal of Pain : Official Journal of the American Pain Society. 9: 1096-105. PMID 18976961 DOI: 10.1016/j.jpain.2008.06.005  1
2008 King TE, Pawar SC, Majuta L, Sroka IC, Wynn D, Demetriou MC, Nagle RB, Porreca F, Cress AE. The role of alpha 6 integrin in prostate cancer migration and bone pain in a novel xenograft model. Plos One. 3: e3535. PMID 18958175 DOI: 10.1371/journal.pone.0003535  1
2008 Yamamoto T, Nair P, Jacobsen NE, Davis P, Ma SW, Navratilova E, Moye S, Lai J, Yamamura HI, Vanderah TW, Porreca F, Hruby VJ. The importance of micelle-bound states for the bioactivities of bifunctional peptide derivatives for delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists. Journal of Medicinal Chemistry. 51: 6334-47. PMID 18821747 DOI: 10.1021/jm800389v  1
2008 Vera-Portocarrero LP, Ossipov MH, King T, Porreca F. Reversal of inflammatory and noninflammatory visceral pain by central or peripheral actions of sumatriptan. Gastroenterology. 135: 1369-78. PMID 18694754 DOI: 10.1053/j.gastro.2008.06.085  1
2008 Agnes RS, Ying J, Kövér KE, Lee YS, Davis P, Ma SW, Badghisi H, Porreca F, Lai J, Hruby VJ. Structure-activity relationships of bifunctional cyclic disulfide peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. Peptides. 29: 1413-23. PMID 18502541 DOI: 10.1016/j.peptides.2008.03.022  1
2008 Lai J, Luo MC, Chen Q, Porreca F. Pronociceptive actions of dynorphin via bradykinin receptors. Neuroscience Letters. 437: 175-9. PMID 18450375 DOI: 10.1016/j.neulet.2008.03.088  1
2008 Wang R, King T, Ossipov MH, Rossomando AJ, Vanderah TW, Harvey P, Cariani P, Frank E, Sah DW, Porreca F. Persistent restoration of sensory function by immediate or delayed systemic artemin after dorsal root injury. Nature Neuroscience. 11: 488-96. PMID 18344995 DOI: 10.1038/nn2069  1
2008 Vanderah TW, Largent-Milnes T, Lai J, Porreca F, Houghten RA, Menzaghi F, Wisniewski K, Stalewski J, Sueiras-Diaz J, Galyean R, Schteingart C, Junien JL, Trojnar J, Rivière PJ. Novel D-amino acid tetrapeptides produce potent antinociception by selectively acting at peripheral kappa-opioid receptors. European Journal of Pharmacology. 583: 62-72. PMID 18282565 DOI: 10.1016/j.ejphar.2008.01.011  1
2008 Yamamoto T, Nair P, Vagner J, Largent-Milnes T, Davis P, Ma SW, Navratilova E, Moye S, Tumati S, Lai J, Yamamura HI, Vanderah TW, Porreca F, Hruby VJ. A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists. Journal of Medicinal Chemistry. 51: 1369-76. PMID 18266313 DOI: 10.1021/jm070332f  1
2008 Salvadori S, Fiorini S, Trapella C, Porreca F, Davis P, Sasaki Y, Ambo A, Marczak ED, Lazarus LH, Balboni G. Role of benzimidazole (Bid) in the delta-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH(2)-Bid (UFP-502). Bioorganic & Medicinal Chemistry. 16: 3032-8. PMID 18178091 DOI: 10.1016/j.bmc.2007.12.032  1
2008 Lee YS, Agnes RS, Cain JP, Kulkarni V, Cai M, Salibay C, Ciano K, Petrov R, Mayorov A, Vagner J, Trivedi D, Davis P, Ma SW, Lai J, Porreca F, et al. Opioid and melanocortin receptors: do they have overlapping pharmacophores? Biopolymers. 90: 433-8. PMID 17657709 DOI: 10.1002/bip.20814  1
2007 Khanolkar AD, Lu D, Ibrahim M, Duclos RI, Thakur GA, Malan TP, Porreca F, Veerappan V, Tian X, George C, Parrish DA, Papahatjis DP, Makriyannis A. Cannabilactones: a novel class of CB2 selective agonists with peripheral analgesic activity. Journal of Medicinal Chemistry. 50: 6493-500. PMID 18038967 DOI: 10.1021/jm070441u  1
2007 Muscoli C, Cuzzocrea S, Ndengele MM, Mollace V, Porreca F, Fabrizi F, Esposito E, Masini E, Matuschak GM, Salvemini D. Therapeutic manipulation of peroxynitrite attenuates the development of opiate-induced antinociceptive tolerance in mice. The Journal of Clinical Investigation. 117: 3530-9. PMID 17975673 DOI: 10.1172/JCI32420  1
2007 Lee YS, Petrov R, Park CK, Ma SW, Davis P, Lai J, Porreca F, Vardanyan R, Hruby VJ. Development of novel enkephalin analogues that have enhanced opioid activities at both mu and delta opioid receptors. Journal of Medicinal Chemistry. 50: 5528-32. PMID 17927164 DOI: 10.1021/jm061465o  1
2007 King T, Vardanyan A, Majuta L, Melemedjian O, Nagle R, Cress AE, Vanderah TW, Lai J, Porreca F. Morphine treatment accelerates sarcoma-induced bone pain, bone loss, and spontaneous fracture in a murine model of bone cancer. Pain. 132: 154-68. PMID 17706870 DOI: 10.1016/j.pain.2007.06.026  1
2007 Ossipov MH, Bazov I, Gardell LR, Kowal J, Yakovleva T, Usynin I, Ekström TJ, Porreca F, Bakalkin G. Control of chronic pain by the ubiquitin proteasome system in the spinal cord. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 8226-37. PMID 17670969 DOI: 10.1523/JNEUROSCI.5126-06.2007  1
2007 Mollica A, Guardiani G, Davis P, Ma SW, Porreca F, Lai J, Mannina L, Sobolev AP, Hruby VJ. Synthesis of stable and potent delta/mu opioid peptides: analogues of H-Tyr-c[D-Cys-Gly-Phe-D-Cys]-OH by ring-closing metathesis. Journal of Medicinal Chemistry. 50: 3138-42. PMID 17539621 DOI: 10.1021/jm061048b  1
2007 Yamamoto T, Nair P, Davis P, Ma SW, Navratilova E, Moye S, Tumati S, Lai J, Vanderah TW, Yamamura HI, Porreca F, Hruby VJ. Design, synthesis, and biological evaluation of novel bifunctional C-terminal-modified peptides for delta/mu opioid receptor agonists and neurokinin-1 receptor antagonists. Journal of Medicinal Chemistry. 50: 2779-86. PMID 17516639 DOI: 10.1021/jm061369n  1
2007 Dogrul A, Gülmez SE, Deveci MS, Gul H, Ossipov MH, Porreca F, Tulunay FC. The local antinociceptive actions of nonsteroidal antiinflammatory drugs in the mouse radiant heat tail-flick test. Anesthesia and Analgesia. 104: 927-35. PMID 17377109 DOI: 10.1213/01.ane.0000258773.46897.34  1
2007 Lee YS, Nyberg J, Moye S, Agnes RS, Davis P, Ma SW, Lai J, Porreca F, Vardanyan R, Hruby VJ. Understanding the structural requirements of 4-anilidopiperidine analogues for biological activities at mu and delta opioid receptors. Bioorganic & Medicinal Chemistry Letters. 17: 2161-5. PMID 17329100 DOI: 10.1016/j.bmcl.2007.01.114  1
2007 Lowery JJ, Yeomans L, Keyari CM, Davis P, Porreca F, Knapp BI, Bidlack JM, Bilsky EJ, Polt R. Glycosylation improves the central effects of DAMGO. Chemical Biology & Drug Design. 69: 41-7. PMID 17313456 DOI: 10.1111/j.1747-0285.2007.00462.x  1
2007 Martin TJ, Kim SA, Buechler NL, Porreca F, Eisenach JC. Opioid self-administration in the nerve-injured rat: relevance of antiallodynic effects to drug consumption and effects of intrathecal analgesics. Anesthesiology. 106: 312-22. PMID 17264726 DOI: 10.1097/00000542-200702000-00020  1
2007 Lee YS, Agnes RS, Davis P, Ma SW, Badghisi H, Lai J, Porreca F, Hruby VJ. Partial retro-inverso, retro, and inverso modifications of hydrazide linked bifunctional peptides for opioid and cholecystokinin (CCK) receptors. Journal of Medicinal Chemistry. 50: 165-8. PMID 17201419 DOI: 10.1021/jm061268p  1
2007 Zhang ET, Ossipov MH, Zhang DQ, Lai J, Porreca F. Nerve injury-induced tactile allodynia is present in the absence of FOS labeling in retrogradely labeled post-synaptic dorsal column neurons. Pain. 129: 143-54. PMID 17156921 DOI: 10.1016/j.pain.2006.10.009  1
2007 Vera-Portocarrero LP, Zhang ET, King T, Ossipov MH, Vanderah TW, Lai J, Porreca F. Spinal NK-1 receptor expressing neurons mediate opioid-induced hyperalgesia and antinociceptive tolerance via activation of descending pathways. Pain. 129: 35-45. PMID 17123731 DOI: 10.1016/j.pain.2006.09.033  1
2007 Shinoda K, Hruby VJ, Porreca F. Antihyperalgesic effects of loperamide in a model of rat neuropathic pain are mediated by peripheral delta-opioid receptors. Neuroscience Letters. 411: 143-6. PMID 17110034 DOI: 10.1016/j.neulet.2006.10.027  1
2006 Ossipov MH, Porreca F. Chapter 14 Descending excitatory systems. Handbook of Clinical Neurology. 81: 193-210. PMID 18808836 DOI: 10.1016/S0072-9752(06)80018-7  1
2006 Ndungu JM, Cain JP, Davis P, Ma SW, Vanderah TW, Lai J, Porreca F, Hruby VJ. Synthesis of constrained analogues of cholecystokinin/opioid chimeric peptides. Tetrahedron Letters. 47: 2233-2236. PMID 17203138 DOI: 10.1016/j.tetlet.2006.01.096  1
2006 Lai J, Luo MC, Chen Q, Ma S, Gardell LR, Ossipov MH, Porreca F. Dynorphin A activates bradykinin receptors to maintain neuropathic pain. Nature Neuroscience. 9: 1534-40. PMID 17115041 DOI: 10.1038/nn1804  1
2006 Hruby VJ, Porreca F, Yamamura HI, Tollin G, Agnes RS, Lee YS, Cai M, Alves I, Cowell S, Varga E, Davis P, Salamon Z, Roeske W, Vanderah T, Lai J. New paradigms and tools in drug design for pain and addiction. The Aaps Journal. 8: E450-60. PMID 17025262 DOI: 10.1208/aapsj080353  1
2006 Suzuki R, Porreca F, Dickenson AH. Evidence for spinal dorsal horn hyperexcitability in rats following sustained morphine exposure. Neuroscience Letters. 407: 156-61. PMID 16959420 DOI: 10.1016/j.neulet.2006.08.027  1
2006 Petrov RR, Vardanyan RS, Lee YS, Ma SW, Davis P, Begay LJ, Lai JY, Porreca F, Hruby VJ. Synthesis and evaluation of 3-aminopropionyl substituted fentanyl analogues for opioid activity. Bioorganic & Medicinal Chemistry Letters. 16: 4946-50. PMID 16828552 DOI: 10.1016/j.bmcl.2006.06.040  1
2006 King T, Rao S, Vanderah T, Chen Q, Vardanyan A, Porreca F. Differential blockade of nerve injury-induced shift in weight bearing and thermal and tactile hypersensitivity by milnacipran. The Journal of Pain : Official Journal of the American Pain Society. 7: 513-20. PMID 16814690 DOI: 10.1016/j.jpain.2006.02.001  1
2006 Negri L, Lattanzi R, Giannini E, Colucci M, Margheriti F, Melchiorri P, Vellani V, Tian H, De Felice M, Porreca F. Impaired nociception and inflammatory pain sensation in mice lacking the prokineticin receptor PKR1: focus on interaction between PKR1 and the capsaicin receptor TRPV1 in pain behavior. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 6716-27. PMID 16793879 DOI: 10.1523/JNEUROSCI.5403-05.2006  1
2006 Vera-Portocarrero LP, Xie JY, Yie JX, Kowal J, Ossipov MH, King T, Porreca F. Descending facilitation from the rostral ventromedial medulla maintains visceral pain in rats with experimental pancreatitis. Gastroenterology. 130: 2155-64. PMID 16762636 DOI: 10.1053/j.gastro.2006.03.025  1
2006 Agnes RS, Lee YS, Davis P, Ma SW, Badghisi H, Porreca F, Lai J, Hruby VJ. Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. Journal of Medicinal Chemistry. 49: 2868-75. PMID 16686530 DOI: 10.1021/jm050921q  1
2006 Vera-Portocarrero LP, Zhang ET, Ossipov MH, Xie JY, King T, Lai J, Porreca F. Descending facilitation from the rostral ventromedial medulla maintains nerve injury-induced central sensitization. Neuroscience. 140: 1311-20. PMID 16650614 DOI: 10.1016/j.neuroscience.2006.03.016  1
2006 Amir R, Argoff CE, Bennett GJ, Cummins TR, Durieux ME, Gerner P, Gold MS, Porreca F, Strichartz GR. The role of sodium channels in chronic inflammatory and neuropathic pain. The Journal of Pain : Official Journal of the American Pain Society. 7: S1-29. PMID 16632328 DOI: 10.1016/j.jpain.2006.01.444  1
2006 Porreca F, Vanderah TW, Guo W, Barth M, Dodey P, Peyrou V, Luccarini JM, Junien JL, Pruneau D. Antinociceptive pharmacology of N-[[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]methyl]-2-[2-[[(4-methoxy-2,6-dimethylphenyl) sulfonyl]methylamino]ethoxy]-N-methylacetamide, fumarate (LF22-0542), a novel nonpeptidic bradykinin B1 receptor antagonist. The Journal of Pharmacology and Experimental Therapeutics. 318: 195-205. PMID 16565167 DOI: 10.1124/jpet.105.098368  1
2006 Lee YS, Agnes RS, Badghisi H, Davis P, Ma SW, Lai J, Porreca F, Hruby VJ. Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists. Journal of Medicinal Chemistry. 49: 1773-80. PMID 16509592 DOI: 10.1021/jm050851n  1
2006 Gardell LR, King T, Ossipov MH, Rice KC, Lai J, Vanderah TW, Porreca F. Opioid receptor-mediated hyperalgesia and antinociceptive tolerance induced by sustained opiate delivery. Neuroscience Letters. 396: 44-9. PMID 16343768 DOI: 10.1016/j.neulet.2005.11.009  1
2006 Mollica A, Davis P, Ma SW, Porreca F, Lai J, Hruby VJ. Synthesis and biological activity of the first cyclic biphalin analogues. Bioorganic & Medicinal Chemistry Letters. 16: 367-72. PMID 16275086 DOI: 10.1016/j.bmcl.2005.09.080  1
2006 Ossipov MH, Porreca F. Chronic pain: multiple manifestations, multiple mechanisms Drug Discovery Today: Disease Mechanisms. 3: 301-303. DOI: 10.1016/j.ddmec.2006.09.008  1
2006 Sah DYW, Porreca F, Ossipov MH. Modulation of neurotrophic growth factors as a therapeutic strategy for neuropathic pain Drug Development Research. 67: 389-403. DOI: 10.1002/ddr.20102  1
2005 Ossipov MH, Porreca F. Challenges in the development of novel treatment strategies for neuropathic pain. Neurorx : the Journal of the American Society For Experimental Neurotherapeutics. 2: 650-61. PMID 16489372 DOI: 10.1602/neurorx.2.4.650  1
2005 Dogrul A, Bilsky EJ, Ossipov MH, Lai J, Porreca F. Spinal L-type calcium channel blockade abolishes opioid-induced sensory hypersensitivity and antinociceptive tolerance. Anesthesia and Analgesia. 101: 1730-5. PMID 16301251 DOI: 10.1213/01.ANE.0000184253.49849.B0  1
2005 King T, Ossipov MH, Vanderah TW, Porreca F, Lai J. Is paradoxical pain induced by sustained opioid exposure an underlying mechanism of opioid antinociceptive tolerance? Neuro-Signals. 14: 194-205. PMID 16215302 DOI: 10.1159/000087658  1
2005 Luo MC, Zhang DQ, Ma SW, Huang YY, Shuster SJ, Porreca F, Lai J. An efficient intrathecal delivery of small interfering RNA to the spinal cord and peripheral neurons. Molecular Pain. 1: 29. PMID 16191203 DOI: 10.1186/1744-8069-1-29  1
2005 Malan TP, Porreca F. Lipid mediators regulating pain sensitivity. Prostaglandins & Other Lipid Mediators. 77: 123-30. PMID 16099397 DOI: 10.1016/j.prostaglandins.2004.09.008  1
2005 Sah DW, Ossipov MH, Rossomando A, Silvian L, Porreca F. New approaches for the treatment of pain: the GDNF family of neurotrophic growth factors. Current Topics in Medicinal Chemistry. 5: 577-83. PMID 16022680 DOI: 10.2174/1568026054367593  1
2005 King T, Gardell LR, Wang R, Vardanyan A, Ossipov MH, Malan TP, Vanderah TW, Hunt SP, Hruby VJ, Lai J, Porreca F. Role of NK-1 neurotransmission in opioid-induced hyperalgesia. Pain. 116: 276-88. PMID 15964684 DOI: 10.1016/j.pain.2005.04.014  1
2005 Mollica A, Davis P, Ma SW, Lai J, Porreca F, Hruby VJ. Synthesis and biological evaluation of new biphalin analogues with non-hydrazine linkers. Bioorganic & Medicinal Chemistry Letters. 15: 2471-5. PMID 15863299 DOI: 10.1016/j.bmcl.2005.03.067  1
2005 Dhanasekaran M, Palian MM, Alves I, Yeomans L, Keyari CM, Davis P, Bilsky EJ, Egleton RD, Yamamura HI, Jacobsen NE, Tollin G, Hruby VJ, Porreca F, Polt R. Glycopeptides related to beta-endorphin adopt helical amphipathic conformations in the presence of lipid bilayers. Journal of the American Chemical Society. 127: 5435-48. PMID 15826181 DOI: 10.1021/ja0432158  1
2005 Ossipov MH, Lai J, King T, Vanderah TW, Porreca F. Underlying mechanisms of pronociceptive consequences of prolonged morphine exposure. Biopolymers. 80: 319-24. PMID 15795927 DOI: 10.1002/bip.20254  1
2005 Ibrahim MM, Porreca F, Lai J, Albrecht PJ, Rice FL, Khodorova A, Davar G, Makriyannis A, Vanderah TW, Mata HP, Malan TP. CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids. Proceedings of the National Academy of Sciences of the United States of America. 102: 3093-8. PMID 15705714 DOI: 10.1073/pnas.0409888102  1
2005 Varga EV, Hosohata K, Borys D, Navratilova E, Nylen A, Vanderah TW, Porreca F, Roeske WR, Yamamura HI. Antinociception depends on the presence of G protein gamma2-subunits in brain. European Journal of Pharmacology. 508: 93-8. PMID 15680258 DOI: 10.1016/j.ejphar.2004.11.062  1
2005 Gu X, Ying J, Min B, Cain JP, Davis P, Willey P, Navratilova E, Yamamura HI, Porreca F, Hruby VJ. Parallel synthesis and biological evaluation of different sizes of bicyclo[2,3]-Leu-enkephalin analogues. Biopolymers. 80: 151-63. PMID 15660379 DOI: 10.1002/bip.20208  1
2005 Xie JY, Herman DS, Stiller CO, Gardell LR, Ossipov MH, Lai J, Porreca F, Vanderah TW. Cholecystokinin in the rostral ventromedial medulla mediates opioid-induced hyperalgesia and antinociceptive tolerance. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 409-16. PMID 15647484 DOI: 10.1523/JNEUROSCI.4054-04.2005  1
2005 Gavva NR, Tamir R, Qu Y, Klionsky L, Zhang TJ, Immke D, Wang J, Zhu D, Vanderah TW, Porreca F, Doherty EM, Norman MH, Wild KD, Bannon AW, Louis JC, et al. AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties. The Journal of Pharmacology and Experimental Therapeutics. 313: 474-84. PMID 15615864 DOI: 10.1124/jpet.104.079855  1
2005 Egleton RD, Bilsky EJ, Tollin G, Dhanasekaran M, Lowery J, Alves I, Davis P, Porreca F, Yamamura HI, Yeomans L, Keyari CM, Polt R. Biousian glycopeptides penetrate the blood-brain barrier Tetrahedron Asymmetry. 16: 65-75. DOI: 10.1016/j.tetasy.2004.11.038  1
2005 Fredholm B, Porreca F. Life Sciences: Editorial Life Sciences. 78: 1. DOI: 10.1016/j.lfs.2005.09.015  1
2004 Ossipov MH, Lai J, King T, Vanderah TW, Malan TP, Hruby VJ, Porreca F. Antinociceptive and nociceptive actions of opioids. Journal of Neurobiology. 61: 126-48. PMID 15362157 DOI: 10.1002/neu.20091  1
2004 Gu X, Ying J, Agnes RS, Navratilova E, Davis P, Stahl G, Porreca F, Yamamura HI, Hruby VJ. Novel design of bicyclic beta-turn dipeptides on solid-phase supports and synthesis of [3.3.0]-Bicyclo([2,3])-leu-enkephalin analogues. Organic Letters. 6: 3285-8. PMID 15355033 DOI: 10.1021/ol0488183  1
2004 Chen Q, King T, Vanderah TW, Ossipov MH, Malan TP, Lai J, Porreca F. Differential blockade of nerve injury-induced thermal and tactile hypersensitivity by systemically administered brain-penetrating and peripherally restricted local anesthetics. The Journal of Pain : Official Journal of the American Pain Society. 5: 281-9. PMID 15219260 DOI: 10.1016/j.jpain.2004.05.002  1
2004 Quartilho A, Mata HP, Ibrahim MM, Vanderah TW, Ossipov MH, Lai J, Porreca F, Malan TP. Production of paradoxical sensory hypersensitivity by alpha 2-adrenoreceptor agonists. Anesthesiology. 100: 1538-44. PMID 15166576 DOI: 10.1097/00000542-200406000-00029  1
2004 Elmagbari NO, Egleton RD, Palian MM, Lowery JJ, Schmid WR, Davis P, Navratilova E, Dhanasekaran M, Keyari CM, Yamamura HI, Porreca F, Hruby VJ, Polt R, Bilsky EJ. Antinociceptive structure-activity studies with enkephalin-based opioid glycopeptides. The Journal of Pharmacology and Experimental Therapeutics. 311: 290-7. PMID 15166257 DOI: 10.1124/jpet.104.069393  1
2004 Alves I, Cowell S, Lee YS, Tang X, Davis P, Porreca F, Hruby VJ. A novel 3-step enantioselective synthesis of pyrenylalanine with subsequent incorporation into opioid, CCK, and melanotropin ligands. Biochemical and Biophysical Research Communications. 318: 335-40. PMID 15120606 DOI: 10.1016/j.bbrc.2004.04.033  1
2004 Ananthan S, Khare NK, Saini SK, Seitz LE, Bartlett JL, Davis P, Dersch CM, Porreca F, Rothman RB, Bilsky EJ. Identification of opioid ligands possessing mixed micro agonist/delta antagonist activity among pyridomorphinans derived from naloxone, oxymorphone, and hydromorphone [correction of hydropmorphone]. Journal of Medicinal Chemistry. 47: 1400-12. PMID 14998329 DOI: 10.1021/jm030311v  1
2004 Gavva NR, Klionsky L, Qu Y, Shi L, Tamir R, Edenson S, Zhang TJ, Viswanadhan VN, Toth A, Pearce LV, Vanderah TW, Porreca F, Blumberg PM, Lile J, Sun Y, et al. Molecular determinants of vanilloid sensitivity in TRPV1. The Journal of Biological Chemistry. 279: 20283-95. PMID 14996838 DOI: 10.1074/jbc.M312577200  1
2004 Wang ZQ, Porreca F, Cuzzocrea S, Galen K, Lightfoot R, Masini E, Muscoli C, Mollace V, Ndengele M, Ischiropoulos H, Salvemini D. A newly identified role for superoxide in inflammatory pain. The Journal of Pharmacology and Experimental Therapeutics. 309: 869-78. PMID 14988418 DOI: 10.1124/jpet.103.064154  1
2004 Koetzner L, Hua XY, Lai J, Porreca F, Yaksh T. Nonopioid actions of intrathecal dynorphin evoke spinal excitatory amino acid and prostaglandin E2 release mediated by cyclooxygenase-1 and -2. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 1451-8. PMID 14960618 DOI: 10.1523/JNEUROSCI.1517-03.2004  1
2004 Lai J, Porreca F, Hunter JC, Gold MS. Voltage-gated sodium channels and hyperalgesia. Annual Review of Pharmacology and Toxicology. 44: 371-97. PMID 14744251 DOI: 10.1146/annurev.pharmtox.44.101802.121627  1
2003 Gardell LR, Wang R, Ehrenfels C, Ossipov MH, Rossomando AJ, Miller S, Buckley C, Cai AK, Tse A, Foley SF, Gong B, Walus L, Carmillo P, Worley D, Huang C, ... ... Porreca F, et al. Multiple actions of systemic artemin in experimental neuropathy. Nature Medicine. 9: 1383-9. PMID 14528299 DOI: 10.1038/nm944  1
2003 Quartilho A, Mata HP, Ibrahim MM, Vanderah TW, Porreca F, Makriyannis A, Malan TP. Inhibition of inflammatory hyperalgesia by activation of peripheral CB2 cannabinoid receptors. Anesthesiology. 99: 955-60. PMID 14508331 DOI: 10.1097/00000542-200310000-00031  1
2003 Dogrul A, Gardell LR, Ossipov MH, Tulunay FC, Lai J, Porreca F. Reversal of experimental neuropathic pain by T-type calcium channel blockers. Pain. 105: 159-68. PMID 14499432 DOI: 10.1016/S0304-3959(03)00177-5  1
2003 Gardell LR, Vanderah TW, Gardell SE, Wang R, Ossipov MH, Lai J, Porreca F. Enhanced evoked excitatory transmitter release in experimental neuropathy requires descending facilitation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 8370-9. PMID 12967999  1
2003 Ananthan S, Khare NK, Saini SK, Davis P, Dersch CM, Porreca F, Rothman RB. Novel ligands for the opioid receptors: synthesis and structure-activity relationships among 5'-aryl and 5'-heteroaryl 17-cyclopropylmethyl-4,5 alpha-epoxypyrido[2',3':6,7]morphinans. Bioorganic & Medicinal Chemistry. 11: 4143-54. PMID 12927876 DOI: 10.1016/S0968-0896(03)00432-2  1
2003 Ibrahim MM, Deng H, Zvonok A, Cockayne DA, Kwan J, Mata HP, Vanderah TW, Lai J, Porreca F, Makriyannis A, Malan TP. Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS. Proceedings of the National Academy of Sciences of the United States of America. 100: 10529-33. PMID 12917492 DOI: 10.1073/pnas.1834309100  1
2003 Xiong C, Zhang J, Davis P, Wang W, Ying J, Porreca F, Hruby VJ. Stereoselective synthesis of individual isomers of Leu-enkephalin analogues containing substituted beta-turn bicyclic dipeptide mimetics. Chemical Communications (Cambridge, England). 1598-9. PMID 12868772 DOI: 10.1039/b302235h  0.92
2003 Lai J, Hunter JC, Porreca F. The role of voltage-gated sodium channels in neuropathic pain. Current Opinion in Neurobiology. 13: 291-7. PMID 12850213 DOI: 10.1016/S0959-4388(03)00074-6  1
2003 Ossipov MH, Lai J, Vanderah TW, Porreca F. Induction of pain facilitation by sustained opioid exposure: relationship to opioid antinociceptive tolerance. Life Sciences. 73: 783-800. PMID 12801599 DOI: 10.1016/S0024-3205(03)00410-7  1
2003 Hruby VJ, Agnes RS, Davis P, Ma SW, Lee YS, Vanderah TW, Lai J, Porreca F. Design of novel peptide ligands which have opioid agonist activity and CCK antagonist activity for the treatment of pain. Life Sciences. 73: 699-704. PMID 12801591 DOI: 10.1016/S0024-3205(03)00390-4  1
2003 Sah DW, Ossipo MH, Porreca F. Neurotrophic factors as novel therapeutics for neuropathic pain. Nature Reviews. Drug Discovery. 2: 460-72. PMID 12776221 DOI: 10.1038/nrd1107  1
2003 Ananthan S, Kezar HS, Saini SK, Khare NK, Davis P, Dersch CM, Porreca F, Rothman RB. Synthesis, opioid receptor binding, and functional activity of 5'-substituted 17-cyclopropylmethylpyrido[2',3':6,7]morphinans. Bioorganic & Medicinal Chemistry Letters. 13: 529-32. PMID 12565965 DOI: 10.1016/S0960-894X(02)00934-4  1
2003 Malan TP, Ibrahim MM, Lai J, Vanderah TW, Makriyannis A, Porreca F. CB2 cannabinoid receptor agonists: pain relief without psychoactive effects? Current Opinion in Pharmacology. 3: 62-7. PMID 12550743 DOI: 10.1016/S1471-4892(02)00004-8  1
2003 Hosohata K, Varga EV, Alfaro-Lopez J, Tang X, Vanderah TW, Porreca F, Hruby VJ, Roeske WR, Yamamura HI. (2S,3R) beta-methyl-2',6'-dimethyltyrosine-L-tetrahydroisoquinoline-3-carboxylic acid [(2S,3R)TMT-L-Tic-OH] is a potent, selective delta-opioid receptor antagonist in mouse brain. The Journal of Pharmacology and Experimental Therapeutics. 304: 683-8. PMID 12538822 DOI: 10.1124/jpet.102.042929  1
2003 Gold MS, Weinreich D, Kim CS, Wang R, Treanor J, Porreca F, Lai J. Redistribution of Na(V)1.8 in uninjured axons enables neuropathic pain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 158-66. PMID 12514212  1
2003 Rapaka RS, Porreca F. Life Sciences: Preface Life Sciences. 73: 641. DOI: 10.1016/S0024-3205(03)00385-0  1
2002 Malan TP, Ibrahim MM, Vanderah TW, Makriyannis A, Porreca F. Inhibition of pain responses by activation of CB(2) cannabinoid receptors. Chemistry and Physics of Lipids. 121: 191-200. PMID 12505700 DOI: 10.1016/S0009-3084(02)00155-X  1
2002 Gardell LR, Ossipov MH, Vanderah TW, Lai J, Porreca F. Dynorphin-independent spinal cannabinoid antinociception. Pain. 100: 243-8. PMID 12467995 DOI: 10.1016/S0304-3959(02)00173-2  1
2002 Dogrul A, Gardell LR, Ma S, Ossipov MH, Porreca F, Lai J. 'Knock-down' of spinal CB1 receptors produces abnormal pain and elevates spinal dynorphin content in mice. Pain. 100: 203-9. PMID 12435473 DOI: 10.1016/S0304-3959(02)00302-0  1
2002 Ossipov MH, Zhang ET, Carvajal C, Gardell L, Quirion R, Dumont Y, Lai J, Porreca F. Selective mediation of nerve injury-induced tactile hypersensitivity by neuropeptide Y. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 9858-67. PMID 12427842  1
2002 Gardell LR, Wang R, Burgess SE, Ossipov MH, Vanderah TW, Malan TP, Lai J, Porreca F. Sustained morphine exposure induces a spinal dynorphin-dependent enhancement of excitatory transmitter release from primary afferent fibers. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 6747-55. PMID 12151554  1
2002 Gardell LR, Burgess SE, Dogrul A, Ossipov MH, Malan TP, Lai J, Porreca F. Pronociceptive effects of spinal dynorphin promote cannabinoid-induced pain and antinociceptive tolerance. Pain. 98: 79-88. PMID 12098619 DOI: 10.1016/S0304-3959(01)00475-4  1
2002 Porreca F, Ossipov MH, Gebhart GF. Chronic pain and medullary descending facilitation. Trends in Neurosciences. 25: 319-25. PMID 12086751 DOI: 10.1016/S0166-2236(02)02157-4  1
2002 Burgess SE, Gardell LR, Ossipov MH, Malan TP, Vanderah TW, Lai J, Porreca F. Time-dependent descending facilitation from the rostral ventromedial medulla maintains, but does not initiate, neuropathic pain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 5129-36. PMID 12077208  1
2002 Malan TP, Mata HP, Porreca F. Spinal GABA(A) and GABA(B) receptor pharmacology in a rat model of neuropathic pain. Anesthesiology. 96: 1161-7. PMID 11981157 DOI: 10.1097/00000542-200205000-00020  1
2002 Lai J, Gold MS, Kim CS, Bian D, Ossipov MH, Hunter JC, Porreca F. Inhibition of neuropathic pain by decreased expression of the tetrodotoxin-resistant sodium channel, NaV1.8. Pain. 95: 143-52. PMID 11790477  1
2002 Burden JE, Davis P, Porreca F, Spatola AF. Synthesis and biological activities of YkFA analogues: effects of position 4 substitutions and altered ring size on in vitro opioid activity. Bioorganic & Medicinal Chemistry Letters. 12: 213-6. PMID 11755357 DOI: 10.1016/S0960-894X(01)00706-5  1
2001 Ibrahim MM, Mata HP, Chawla M, Lai J, Porreca F, Malan TP. Allodynia and hyperalgesia produced by specific inhibition of spinal c-fos expression: lack of correlation with dynorphin content. The Journal of Pain : Official Journal of the American Pain Society. 2: 241-9. PMID 14622822 DOI: 10.1054/jpai.2001.23135  1
2001 Rasband MN, Park EW, Vanderah TW, Lai J, Porreca F, Trimmer JS. Distinct potassium channels on pain-sensing neurons. Proceedings of the National Academy of Sciences of the United States of America. 98: 13373-8. PMID 11698689 DOI: 10.1073/pnas.231376298  1
2001 Porreca F, Burgess SE, Gardell LR, Vanderah TW, Malan TP, Ossipov MH, Lappi DA, Lai J. Inhibition of neuropathic pain by selective ablation of brainstem medullary cells expressing the mu-opioid receptor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 5281-8. PMID 11438603  1
2001 Simoneau II, Hamza MS, Mata HP, Siegel EM, Vanderah TW, Porreca F, Makriyannis A, Malan TP. The cannabinoid agonist WIN55,212-2 suppresses opioid-induced emesis in ferrets. Anesthesiology. 94: 882-7. PMID 11388542  1
2001 Liao S, Shenderovich M, Kövér KE, Zhang Z, Hosohata K, Davis P, Porreca F, Yamamura HI, Hurby VJ. Synthesis, biology, NMR and conformation studies of the topographically constrained delta-opioid selective peptide analogs of [beta-iPrPhe(3)]deltorphin I. The Journal of Peptide Research : Official Journal of the American Peptide Society. 57: 257-76. PMID 11328484 DOI: 10.1046/j.1397-002X.2000.00000.x  1
2001 Vanderah TW, Ossipov MH, Lai J, Malan TP, Porreca F. Mechanisms of opioid-induced pain and antinociceptive tolerance: descending facilitation and spinal dynorphin. Pain. 92: 5-9. PMID 11323121 DOI: 10.1016/S0304-3959(01)00311-6  1
2001 McLamore S, Ullrich T, Rothman RB, Xu H, Dersch C, Coop A, Davis P, Porreca F, Jacobson AE, Rice KC. Effect of N-alkyl and N-alkenyl substituents in noroxymorphindole, 17-substituted-6,7-dehydro-4,5alpha-epoxy-3,14-dihydroxy-6,7:2',3'-indolomorphinans, on opioid receptor affinity, selectivity, and efficacy. Journal of Medicinal Chemistry. 44: 1471-4. PMID 11311071 DOI: 10.1021/jm000511w  1
2001 Wang Z, Gardell LR, Ossipov MH, Vanderah TW, Brennan MB, Hochgeschwender U, Hruby VJ, Malan TP, Lai J, Porreca F. Pronociceptive actions of dynorphin maintain chronic neuropathic pain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 1779-86. PMID 11222667  1
2001 Lipkowski AW, Misicka A, Hosohata K, Davis P, Yamamura HI, Porreca F, Hruby VJ. Biological properties of Phe(o)-opioid peptide analogues. Life Sciences. 68: 969-72. PMID 11213367 DOI: 10.1016/S0024-3205(00)00993-0  1
2001 Sun H, Ren K, Zhong CM, Ossipov MH, Malan TP, Lai J, Porreca F. Nerve injury-induced tactile allodynia is mediated via ascending spinal dorsal column projections. Pain. 90: 105-11. PMID 11166976 DOI: 10.1016/S0304-3959(00)00392-4  1
2001 Vanderah TW, Suenaga NM, Ossipov MH, Malan TP, Lai J, Porreca F. Tonic descending facilitation from the rostral ventromedial medulla mediates opioid-induced abnormal pain and antinociceptive tolerance. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 279-86. PMID 11150345  1
2000 Tornøe CW, Davis P, Porreca F, Meldal M. Alpha-azido acids for direct use in solid-phase peptide synthesis. Journal of Peptide Science : An Official Publication of the European Peptide Society. 6: 594-602. PMID 11192239 DOI: 10.1002/1099-1387(200012)6:12<594::AID-PSC276>3.0.CO;2-X  0.88
2000 Dogrul A, Ossipov MH, Lai J, Malan TP, Porreca F. Peripheral and spinal antihyperalgesic activity of SIB-1757, a metabotropic glutamate receptor (mGLUR(5)) antagonist, in experimental neuropathic pain in rats. Neuroscience Letters. 292: 115-8. PMID 10998562 DOI: 10.1016/S0304-3940(00)01458-0  1
2000 Vanderah TW, Gardell LR, Burgess SE, Ibrahim M, Dogrul A, Zhong CM, Zhang ET, Malan TP, Ossipov MH, Lai J, Porreca F. Dynorphin promotes abnormal pain and spinal opioid antinociceptive tolerance. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 7074-9. PMID 10995854  1
2000 Kovelowski CJ, Ossipov MH, Sun H, Lai J, Malan TP, Porreca F. Supraspinal cholecystokinin may drive tonic descending facilitation mechanisms to maintain neuropathic pain in the rat. Pain. 87: 265-73. PMID 10963906 DOI: 10.1016/S0304-3959(00)00290-6  1
2000 Furness MS, Zhang X, Coop A, Jacobson AE, Rothman RB, Dersch CM, Xu H, Porreca F, Rice KC. Probes for narcotic receptor-mediated phenomena. 27. Synthesis and pharmacological evaluation of selective delta-opioid receptor agonists from 4-[(alphaR)-alpha-(2S,5R)-4-substituted-2, 5-dimethyl-1-piperazinyl-3-methoxybenzyl]-N,N-diethylbenzamides and their enantiomers. Journal of Medicinal Chemistry. 43: 3193-6. PMID 10956228 DOI: 10.1021/jm0001222  1
2000 Ossipov MH, Hong Sun T, Malan P, Lai J, Porreca F. Mediation of spinal nerve injury induced tactile allodynia by descending facilitatory pathways in the dorsolateral funiculus in rats. Neuroscience Letters. 290: 129-32. PMID 10936694 DOI: 10.1016/S0304-3940(00)01338-0  1
2000 Ossipov MH, Jerussi TP, Ren K, Sun H, Porreca F. Differential effects of spinal (R)-ketoprofen and (S)-ketoprofen against signs of neuropathic pain and tonic nociception: evidence for a novel mechanism of action of (R)-ketoprofen against tactile allodynia. Pain. 87: 193-9. PMID 10924812 DOI: 10.1016/S0304-3959(00)00280-3  0.88
2000 Ossipov MH, Lai J, Malan TP, Porreca F. Spinal and supraspinal mechanisms of neuropathic pain. Annals of the New York Academy of Sciences. 909: 12-24. PMID 10911921 DOI: 10.1111/j.1749-6632.2000.tb06673.x  1
2000 Bilsky EJ, Egleton RD, Mitchell SA, Palian MM, Davis P, Huber JD, Jones H, Yamamura HI, Janders J, Davis TP, Porreca F, Hruby VJ, Polt R. Enkephalin glycopeptide analogues produce analgesia with reduced dependence liability. Journal of Medicinal Chemistry. 43: 2586-90. PMID 10891118 DOI: 10.1021/jm000077y  1
2000 Wahlestedt C, Salmi P, Good L, Kela J, Johnsson T, Hökfelt T, Broberger C, Porreca F, Lai J, Ren K, Ossipov M, Koshkin A, Jakobsen N, Skouv J, Oerum H, et al. Potent and nontoxic antisense oligonucleotides containing locked nucleic acids. Proceedings of the National Academy of Sciences of the United States of America. 97: 5633-8. PMID 10805816 DOI: 10.1073/pnas.97.10.5633  1
2000 Tang Q, Lynch RM, Porreca F, Lai J. Dynorphin A elicits an increase in intracellular calcium in cultured neurons via a non-opioid, non-NMDA mechanism. Journal of Neurophysiology. 83: 2610-5. PMID 10805661  1
2000 Malan TP, Ossipov MH, Gardell LR, Ibrahim M, Bian D, Lai J, Porreca F. Extraterritorial neuropathic pain correlates with multisegmental elevation of spinal dynorphin in nerve-injured rats. Pain. 86: 185-94. PMID 10779675 DOI: 10.1016/S0304-3959(00)00243-8  1
2000 Hosohata K, Logan JK, Varga E, Burkey TH, Vanderah TW, Porreca F, Hruby VJ, Roeske WR, Yamamura HI. The role of the G protein gamma(2) subunit in opioid antinociception in mice. European Journal of Pharmacology. 392: R9-R11. PMID 10762674 DOI: 10.1016/S0014-2999(00)00132-1  1
2000 Bonner GG, Davis P, Stropova D, Edsall S, Yamamura HI, Porreca F, Hruby VJ. Opiate aromatic pharmacophore structure-activity relationships in CTAP analogues determined by topographical bias, two-dimensional NMR, and biological activity assays. Journal of Medicinal Chemistry. 43: 569-80. PMID 10691683 DOI: 10.1021/jm9900218  1
2000 Hosohata Y, Vanderah TW, Burkey TH, Ossipov MH, Kovelowski CJ, Sora I, Uhl GR, Zhang X, Rice KC, Roeske WR, Hruby VJ, Yamamura HI, Lai J, Porreca F. delta-Opioid receptor agonists produce antinociception and [35S]GTPgammaS binding in mu receptor knockout mice. European Journal of Pharmacology. 388: 241-8. PMID 10675732 DOI: 10.1016/S0014-2999(99)00897-3  1
2000 Lai J, Hunter JC, Ossipov MH, Porreca F. Blockade of neuropathic pain by antisense targeting of tetrodotoxin-resistant sodium channels in sensory neurons. Methods in Enzymology. 314: 201-13. PMID 10565014 DOI: 10.1016/S0076-6879(99)14104-1  1
1999 Zhang X, Rice KC, Calderon SN, Kayakiri H, Smith L, Coop A, Jacobson AE, Rothman RB, Davis P, Dersch CM, Porreca F. Probes for narcotic receptor mediated phenomena. 26. Synthesis and biological evaluation of diarylmethylpiperazines and diarylmethylpiperidines as novel, nonpeptidic delta opioid receptor ligands. Journal of Medicinal Chemistry. 42: 5455-63. PMID 10639287 DOI: 10.1021/jm9903895  1
1999 Alfaro-Lopez J, Okayama T, Hosohata K, Davis P, Porreca F, Yamamura HI, Hruby VJ. Exploring the structure-activity relationships of [1-(4-tert-butyl-3'-hydroxy)benzhydryl-4-benzylpiperazine] (SL-3111), a high-affinity and selective delta-opioid receptor nonpeptide agonist ligand. Journal of Medicinal Chemistry. 42: 5359-68. PMID 10639279 DOI: 10.1021/jm990337f  1
1999 Burden JE, Davis P, Porreca F, Spatola AF. Synthesis and biological activities of position one and three transposed analogs of the opioid peptide YKFA. Bioorganic & Medicinal Chemistry Letters. 9: 3441-6. PMID 10617088  1
1999 Kovelowski CJ, Ossipov MH, Hruby VJ, Porreca F. Lesions of the dorsolateral funiculus block supraspinal opioid delta receptor mediated antinociception in the rat. Pain. 83: 115-22. PMID 10534582 DOI: 10.1016/S0304-3959(99)00083-4  0.92
1999 Kovelowski CJ, Bian D, Hruby VJ, Lai J, Ossipov MH, Porreca F. Selective opioid delta agonists elicit antinociceptive supraspinal/spinal synergy in the rat. Brain Research. 843: 12-7. PMID 10528105 DOI: 10.1016/S0006-8993(99)01803-X  1
1999 Lipkowski AW, Misicka A, Davis P, Stropova D, Janders J, Lachwa M, Porreca F, Yamamura HI, Hruby VJ. Biological activity of fragments and analogues of the potent dimeric opioid peptide, biphalin. Bioorganic & Medicinal Chemistry Letters. 9: 2763-6. PMID 10509931 DOI: 10.1016/S0960-894X(99)00464-3  1
1999 Ananthan S, Kezar HS, Carter RL, Saini SK, Rice KC, Wells JL, Davis P, Xu H, Dersch CM, Bilsky EJ, Porreca F, Rothman RB. Synthesis, opioid receptor binding, and biological activities of naltrexone-derived pyrido- and pyrimidomorphinans. Journal of Medicinal Chemistry. 42: 3527-38. PMID 10479286 DOI: 10.1021/jm990039i  1
1999 Lashbrook JM, Ossipov MH, Hunter JC, Raffa RB, Tallarida RJ, Porreca F. Synergistic antiallodynic effects of spinal morphine with ketorolac and selective COX1- and COX2-inhibitors in nerve-injured rats. Pain. 82: 65-72. PMID 10422661 DOI: 10.1016/S0304-3959(99)00031-7  0.88
1999 Bian D, Ossipov MH, Ibrahim M, Raffa RB, Tallarida RJ, Malan TP, Lai J, Porreca F. Loss of antiallodynic and antinociceptive spinal/supraspinal morphine synergy in nerve-injured rats: restoration by MK-801 or dynorphin antiserum. Brain Research. 831: 55-63. PMID 10411983 DOI: 10.1016/S0006-8993(99)01393-1  1
1999 Porreca F, Lai J, Bian D, Wegert S, Ossipov MH, Eglen RM, Kassotakis L, Novakovic S, Rabert DK, Sangameswaran L, Hunter JC. A comparison of the potential role of the tetrodotoxin-insensitive sodium channels, PN3/SNS and NaN/SNS2, in rat models of chronic pain. Proceedings of the National Academy of Sciences of the United States of America. 96: 7640-4. PMID 10393873 DOI: 10.1073/pnas.96.14.7640  1
1999 Wang Z, Bilsky EJ, Wang D, Porreca F, Sadée W. 3-Isobutyl-1-methylxanthine inhibits basal mu-opioid receptor phosphorylation and reverses acute morphine tolerance and dependence in mice. European Journal of Pharmacology. 371: 1-9. PMID 10355588 DOI: 10.1016/S0014-2999(99)00131-4  0.84
1999 Bartosz-Bechowski H, Davis P, Slaninova J, Malatynska E, Stropova D, Porreca F, Yamamura HI, Hruby VJ. Cyclic enkephalin analogs that are hybrids of DPDPE-related peptides and metenkephalin-Arg-Gly-Leu: prohormone analogs that retain good potency and selectivity for delta opioid receptors. The Journal of Peptide Research : Official Journal of the American Peptide Society. 53: 329-36. PMID 10231722 DOI: 10.1034/j.1399-3011.1999.00033.x  1
1999 Coop A, Rothman RB, Dersch C, Partilla J, Porreca F, Davis P, Jacobson AE, Rice KC. delta Opioid affinity and selectivity of 4-hydroxy-3-methoxyindolomorphinan analogues related to naltrindole. Journal of Medicinal Chemistry. 42: 1673-9. PMID 10229636 DOI: 10.1021/jm9807003  1
1999 Ossipov MH, Bian D, Malan TP, Lai J, Porreca F. Lack of involvement of capsaicin-sensitive primary afferents in nerve-ligation injury induced tactile allodynia in rats. Pain. 79: 127-33. PMID 10068158 DOI: 10.1016/S0304-3959(98)00187-0  1
1998 Kovelowski CJ, Raffa RB, Porreca F. Tramadol and its enantiomers differentially suppress c-fos-like immunoreactivity in rat brain and spinal cord following acute noxious stimulus. European Journal of Pain (London, England). 2: 211-9. PMID 15102381 DOI: 10.1016/S1090-3801(98)90017-9  1
1998 Li G, Haq W, Xiang L, Lou BS, Hughes R, De Leon IA, Davis P, Gillespie TJ, Romanowski M, Zhu X, Misicka A, Lipkowski AW, Porreca F, Davis TP, Yamamura HI, et al. Modifications of the 4,4'-residues and SAR studies of Biphalin, a highly potent opioid receptor active peptide. Bioorganic & Medicinal Chemistry Letters. 8: 555-60. PMID 9871617 DOI: 10.1016/S0960-894X(98)00065-1  1
1998 Porreca F, Lai J, Malan TP. Can inflammation relieve pain? Nature Medicine. 4: 1359-60. PMID 9846566 DOI: 10.1038/3942  1
1998 Liao S, Alfaro-Lopez J, Shenderovich MD, Hosohata K, Lin J, Li X, Stropova D, Davis P, Jernigan KA, Porreca F, Yamamura HI, Hruby VJ. De novo design, synthesis, and biological activities of high-affinity and selective non-peptide agonists of the delta-opioid receptor. Journal of Medicinal Chemistry. 41: 4767-76. PMID 9822547 DOI: 10.1021/jm980374r  1
1998 Martin TJ, Hairston CT, Lutz PO, Harris LS, Porreca F. Anti-allodynic actions of intravenous opioids in the nerve injured rat: potential utility of heroin and dihydroetorphine against neuropathic pain. European Journal of Pharmacology. 357: 25-32. PMID 9788770 DOI: 10.1016/S0014-2999(98)00531-7  1
1998 Ananthan S, Johnson CA, Carter RL, Clayton SD, Rice KC, Xu H, Davis P, Porreca F, Rothman RB. Synthesis, opioid receptor binding, and bioassay of naltrindole analogues substituted in the indolic benzene moiety. Journal of Medicinal Chemistry. 41: 2872-81. PMID 9667975 DOI: 10.1021/jm980083i  1
1998 Porreca F, Tang QB, Bian D, Riedl M, Elde R, Lai J. Spinal opioid mu receptor expression in lumbar spinal cord of rats following nerve injury. Brain Research. 795: 197-203. PMID 9622629 DOI: 10.1016/S0006-8993(98)00292-3  1
1998 Burkey TH, Ehlert FJ, Hosohata Y, Quock RM, Cowell S, Hosohata K, Varga E, Stropova D, Li X, Slate C, Nagase H, Porreca F, Hruby VJ, Roeske WR, Yamamura HI. The efficacy of delta-opioid receptor-selective drugs. Life Sciences. 62: 1531-6. PMID 9585131 DOI: 10.1016/S0024-3205(98)00102-7  1
1998 Bian D, Ossipov MH, Zhong C, Malan TP, Porreca F. Tactile allodynia, but not thermal hyperalgesia, of the hindlimbs is blocked by spinal transection in rats with nerve injury. Neuroscience Letters. 241: 79-82. PMID 9507925 DOI: 10.1016/S0304-3940(98)00051-2  1
1998 Lu YF, Xu H, Liu-Chen LY, Chen C, Partilla JS, Brine GA, Carroll FI, Rice KC, Lai J, Porreca F, Sadee W, Rothman RB. Opioid peptide receptor studies. 7. The methylfentanyl congener RTI-4614-4 and its four enantiomers bind to different domains of the rat mu opioid receptor. Synapse (New York, N.Y.). 28: 117-24. PMID 9450512 DOI: 10.1002/(SICI)1098-2396(199802)28:2<117::AID-SYN2>3.0.CO;2-E  1
1998 Vanderah TW, Raffa RB, Lashbrook J, Burritt A, Hruby V, Porreca F. Orphanin-fq/nociceptin: Lack of antinociceptive, hyperalgesic or allodynic effects in acute thermal or mechanical tests following intracerebroventricular or intrathecal administration to mice or rats European Journal of Pain. 2: 267-280. DOI: 10.1016/S1090-3801(98)90023-4  1
1997 Hruby VJ, Bartosz-Bechowski H, Davis P, Slaninova J, Zalewska T, Stropova D, Porreca F, Yamamura HI. Cyclic enkephalin analogues with exceptional potency and selectivity for delta-opioid receptors. Journal of Medicinal Chemistry. 40: 3957-62. PMID 9397176 DOI: 10.1021/jm9704762  1
1997 Rao RK, Thomas DW, Pepperl S, Porreca F. Salivary epidermal growth factor plays a role in protection of ileal mucosal integrity. Digestive Diseases and Sciences. 42: 2175-81. PMID 9365155 DOI: 10.1023/A:1018855525989  0.52
1997 Haaseth RC, Zalewska T, Davis P, Yamamura HI, Porreca F, Hruby VJ. Para-substituted phenylalanine-4 analogues of [L-Ala3]DPDPE: highly selective delta opioid receptor ligands. The Journal of Peptide Research : Official Journal of the American Peptide Society. 50: 171-7. PMID 9309580 DOI: 10.1111/J.1399-3011.1997.TB01182.X  1
1997 Katsura Y, Zhang X, Homma K, Rice KC, Calderon SN, Rothman RB, Yamamura HI, Davis P, Flippen-Anderson JL, Xu H, Becketts K, Foltz EJ, Porreca F. Probes for narcotic receptor-mediated phenomena. 25. Synthesis and evaluation of N-alkyl-substituted (alpha-piperazinylbenzyl)benzamides as novel, highly selective delta opioid receptor agonists. Journal of Medicinal Chemistry. 40: 2936-47. PMID 9288176 DOI: 10.1021/jm970106d  1
1997 Misicka A, Cavagnero S, Horvath R, Davis P, Porreca F, Yamamura HI, Hruby VJ. Synthesis and biological properties of beta-MePhe3 analogues of deltorphin I and dermenkephalin: influence of biased chi 1 Phe3 residues on peptide recognition for delta-opioid receptors. The Journal of Peptide Research : Official Journal of the American Peptide Society. 50: 48-54. PMID 9273887 DOI: 10.1111/J.1399-3011.1997.TB00619.X  1
1997 Kramer TH, Bartosz-Bechowski H, Davis P, Hruby VJ, Porreca F. Extraordinary potency of a novel delta opioid receptor agonist is due in part to increased efficacy. Life Sciences. 61: 129-35. PMID 9217271 DOI: 10.1016/S0024-3205(97)00367-6  0.92
1997 Wegert S, Ossipov MH, Nichols ML, Bian D, Vanderah TW, Malan TP, Porreca F. Differential activities of intrathecal MK-801 or morphine to alter responses to thermal and mechanical stimuli in normal or nerve-injured rats. Pain. 71: 57-64. PMID 9200174 DOI: 10.1016/S0304-3959(97)03337-X  1
1997 Quock RM, Hosohata Y, Knapp RJ, Burkey TH, Hosohata K, Zhang X, Rice KC, Nagase H, Hruby VJ, Porreca F, Roeske WR, Yamamura HI. Relative efficacies of delta-opioid receptor agonists at the cloned human delta-opioid receptor. European Journal of Pharmacology. 326: 101-4. PMID 9178661 DOI: 10.1016/S0014-2999(97)83488-7  1
1997 Patel D, McKinley BD, Davis TP, Porreca F, Yamamura HI, Hruby VJ. Peptide targeting and delivery across the blood-brain barrier utilizing synthetic triglyceride esters: design, synthesis, and bioactivity. Bioconjugate Chemistry. 8: 434-41. PMID 9177851 DOI: 10.1021/bc970027g  1
1997 Misicka A, Lipkowski AW, Horvath R, Davis P, Porreca F, Yamamura HI, Hruby VJ. Structure-activity relationship of biphalin. The synthesis and biological activities of new analogues with modifications in positions 3 and 4. Life Sciences. 60: 1263-9. PMID 9096243 DOI: 10.1016/S0024-3205(97)00069-6  1
1997 Nichols ML, Lopez Y, Ossipov MH, Bian D, Porreca F. Enhancement of the antiallodynic and antinociceptive efficacy of spinal morphine by antisera to dynorphin A (1-13) or MK-801 in a nerve-ligation model of peripheral neuropathy. Pain. 69: 317-22. PMID 9085307 DOI: 10.1016/S0304-3959(96)03282-4  1
1997 Calderon SN, Rice KC, Rothman RB, Porreca F, Flippen-Anderson JL, Kayakiri H, Xu H, Becketts K, Smith LE, Bilsky EJ, Davis P, Horvath R. Probes for narcotic receptor mediated phenomena. 23. Synthesis, opioid receptor binding, and bioassay of the highly selective delta agonist (+)-4-[(alpha R)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]- N,N-diethylbenzamide (SNC 80) and related novel nonpeptide delta opioid receptor ligands. Journal of Medicinal Chemistry. 40: 695-704. PMID 9057856 DOI: 10.1021/jm960319n  0.88
1997 Ossipov MH, Lopez Y, Bian D, Nichols ML, Porreca F. Synergistic antinociceptive interactions of morphine and clonidine in rats with nerve-ligation injury. Anesthesiology. 86: 196-204. PMID 9009955 DOI: 10.1097/00000542-199701000-00024  1
1996 Mayfield KP, Kozak W, Malvin GM, Porreca F. Hypoxia decreases opioid delta receptor expression in mouse brain Neuroscience. 72: 785-789. PMID 9157323 DOI: 10.1016/0306-4522(95)00585-4  1
1996 Vanderah TW, Laughlin T, Lashbrook JM, Nichols ML, Wilcox GL, Ossipov MH, Malan TP, Porreca F. Single intrathecal injections of dynorphin A or des-Tyr-dynorphins produce long-lasting allodynia in rats: blockade by MK-801 but not naloxone. Pain. 68: 275-81. PMID 9121815 DOI: 10.1016/S0304-3959(96)03225-3  1
1996 Bilsky EJ, Inturrisi CE, Sadée W, Hruby VJ, Porreca F. Competitive and non-competitive NMDA antagonists block the development of antinociceptive tolerance to morphine, but not to selective μ or δ opioid agonists in mice Pain. 68: 229-237. PMID 9121809 DOI: 10.1016/S0304-3959(96)03185-5  1
1996 Bilsky EJ, Wang T, Lai J, Porreca F. Selective blockade of peripheral delta opioid agonist induced antinociception by intrathecal administration of delta receptor antisense oligodeoxynucleotide. Neuroscience Letters. 220: 155-8. PMID 8994216 DOI: 10.1016/S0304-3940(96)13262-6  1
1996 Lai J, Ma SW, Porreca F, Raffa RB. Tramadol, M1 metabolite and enantiomer affinities for cloned human opioid receptors expressed in transfected HN9.10 neuroblastoma cells. European Journal of Pharmacology. 316: 369-72. PMID 8982709 DOI: 10.1016/S0014-2999(96)00770-4  1
1996 Nichols ML, Bian D, Ossipov MH, Malan TP, Porreca F. Antiallodynic effects of a CCKB antagonist in rats with nerve ligation injury: role of endogenous enkephalins. Neuroscience Letters. 215: 161-4. PMID 8899738 DOI: 10.1016/0304-3940(96)12964-5  1
1996 Lai J, Riedl M, Stone LS, Arvidsson U, Bilsky EJ, Wilcox GL, Elde R, Porreca F. Immunofluorescence analysis of antisense oligodeoxynucleotide-mediated 'knock-down' of the mouse delta opioid receptor in vitro and in vivo. Neuroscience Letters. 213: 205-8. PMID 8873150 DOI: 10.1016/0304-3940(96)12883-4  1
1996 Rao R, Porreca F. Epidermal growth factor protects mouse ileal mucosa from Triton X-100-induced injury European Journal of Pharmacology. 303: 209-212. PMID 8813570 DOI: 10.1016/0014-2999(96)00186-0  1
1996 Zaki PA, Bilsky EJ, Vanderah TW, Lai J, Evans CJ, Porreca F. Opioid receptor types and subtypes: the delta receptor as a model. Annual Review of Pharmacology and Toxicology. 36: 379-401. PMID 8725395 DOI: 10.1146/annurev.pa.36.040196.002115  1
1996 Lung FD, Meyer JP, Lou BS, Xiang L, Li G, Davis P, DeLeon IA, Yamamura HI, Porreca F, Hruby VJ. Effects of modifications of residues in position 3 of dynorphin A(1-11)-NH2 on kappa receptor selectivity and potency. Journal of Medicinal Chemistry. 39: 2456-60. PMID 8691442 DOI: 10.1021/jm950655o  1
1996 Lung FD, Collins N, Stropova D, Davis P, Yamamura HI, Porreca F, Hruby VJ. Design, synthesis, and biological activities of cyclic lactam peptide analogues of dynorphine A(1-11)-NH2. Journal of Medicinal Chemistry. 39: 1136-41. PMID 8676350 DOI: 10.1021/jm950369c  1
1996 Ossipov MH, Kovelowski CJ, Nichols ML, Hruby VJ, Porreca F. Characterization of supraspinal antinociceptive actions of opioid delta agonists in the rat. Pain. 62: 287-93. PMID 8657428 DOI: 10.1016/0304-3959(94)00231-3  0.36
1996 Bertha CM, Ellis M, Flippen-Anderson JL, Porreca F, Rothman RB, Davis P, Xu H, Becketts K, Rice KC. Probes for narcotic receptor-mediated phenomena. 21. Novel derivatives of 3-(1,2,3,4,5,11-hexahydro-3-methyl-2,6-methano-6H-azocino[4,5-b]indol- 6-yl)-phenols with improved delta opioid receptor selectivity. Journal of Medicinal Chemistry. 39: 2081-6. PMID 8642567 DOI: 10.1021/jm950695s  0.88
1996 Qian X, Shenderovich MD, Kover KE, Davis P, Horvath R, Zalewska T, Yamamura HI, Porreca F, Hruby VJ. Probing the stereochemical requirements for receptor recognition of δ opioid agonists through topographic modifications in position 1 Journal of the American Chemical Society. 118: 7280-7290. DOI: 10.1021/ja954241w  1
1995 Lai J, Bilsky EJ, Porreca F. Treatment with antisense oligodeoxynucleotide to a conserved sequence of opioid receptors inhibits antinociceptive effects of delta subtype selective ligands Journal of Receptors and Signal Transduction. 15: 643-650. PMID 8903970 DOI: 10.3109/10799899509045246  1
1995 Rao RK, Lopez Y, Lai J, Riviere PJ, Junien JL, Porreca F. Attenuation of gastrin-induced gastric acid secretion by antisense oligonucleotide to the CCKB/gastrin receptor. Neuroreport. 6: 2373-7. PMID 8747156 DOI: 10.1097/00001756-199511270-00023  1
1995 Ossipov MH, Lopez Y, Nichols ML, Bian D, Porreca F. The loss of antinociceptive efficacy of spinal morphine in rats with nerve ligation injury is prevented by reducing spinal afferent drive. Neuroscience Letters. 199: 87-90. PMID 8584250 DOI: 10.1016/0304-3940(95)12022-V  1
1995 Ossipov MH, Lopez Y, Nichols ML, Bian D, Porreca F. Inhibition by spinal morphine of the tail-flick response is attenuated in rats with nerve ligation injury. Neuroscience Letters. 199: 83-6. PMID 8584249 DOI: 10.1016/0304-3940(95)12026-Z  1
1995 Bian D, Nichols ML, Ossipov MH, Lai J, Porreca F. Characterization of the antiallodynic efficacy of morphine in a model of neuropathic pain in rats. Neuroreport. 6: 1981-4. PMID 8580422 DOI: 10.1097/00001756-199510010-00007  1
1995 Lung FD, Meyer JP, Li G, Lou BS, Stropova D, Davis P, Yamamura HI, Porreca F, Hruby VJ. Highly kappa receptor-selective dynorphin A analogues with modifications in position 3 of dynorphin A(1-11)-NH2. Journal of Medicinal Chemistry. 38: 585-6. PMID 7861405 DOI: 10.1021/JM00004A002  1
1995 Beutler AS, Banck MS, Bach FW, Gage FH, Porreca F, Bilsky EJ, Yaksh TL. Retrovirus-mediated expression of an artificial beta-endorphin precursor in primary fibroblasts. Journal of Neurochemistry. 64: 475-81. PMID 7830038 DOI: 10.1046/J.1471-4159.1995.64020475.X  0.64
1995 Cha XY, Xu H, Rice KC, Porreca F, Lai J, Ananthan S, Rothman RB. Opioid peptide receptor studies. 1. Identification of a novel delta-opioid receptor binding site in rat brain membranes. Peptides. 16: 191-8. PMID 7784248 DOI: 10.1016/0196-9781(94)00182-0  1
1995 Bertha CM, Flippen-Anderson JL, Rothman RB, Porreca F, Davis P, Xu H, Becketts K, Cha XY, Rice KC. Probes for narcotic receptor-mediated phenomena. 20. Alteration of opioid receptor subtype selectivity of the 5-(3-hydroxyphenyl)morphans by application of the message-address concept: preparation of delta-opioid receptor ligands. Journal of Medicinal Chemistry. 38: 1523-37. PMID 7739011 DOI: 10.1021/JM00009A013  0.88
1995 Ossipov MH, Kovelowski CJ, Porreca F. The increase in morphine antinociceptive potency produced by carrageenan-induced hindpaw inflammation is blocked by naltrindole, a selective δ-opioid antagonist Neuroscience Letters. 184: 173-176. PMID 7715840 DOI: 10.1016/0304-3940(94)11199-S  1
1995 Craft RM, Cohen SM, Porreca F. Long-lasting desensitization of bladder afferents following intravesical resiniferatoxin and capsaicin in the rat. Pain. 61: 317-23. PMID 7659443 DOI: 10.1016/0304-3959(94)00193-I  1
1995 Meyer JP, Davis P, Lee KB, Porreca F, Yamamura HI, Hruby VJ. Synthesis using a Fmoc-based strategy and biological activities of some reduced peptide bond pseudopeptide analogues of dynorphin A1. Journal of Medicinal Chemistry. 38: 3462-8. PMID 7658433 DOI: 10.1021/JM00018A006  1
1995 Mayfield KP, Horvath R, Lai J, Porreca F. Increased expression of opioid delta receptors by deoxy conformation heme proteins in NG108-15 cells Brain Research. 676: 358-362. PMID 7614006 DOI: 10.1016/0006-8993(95)00089-9  1
1995 Hruby VJ, Yamamura HI, Porreca F. Molecular organization of receptors. Efficacy, agonists, and antagonists. Annals of the New York Academy of Sciences. 757: 7-22. PMID 7611710 DOI: 10.1111/j.1749-6632.1995.tb17461.x  1
1995 Rao RK, Pepperl S, Porreca F. Tonic suppression of gastric acid secretion by endogenous peptides in neonatal rats American Journal of Physiology - Gastrointestinal and Liver Physiology. 269. PMID 7491964 DOI: 10.1152/AJPGI.1995.269.5.G721  1
1995 Reid LD, Glick SD, Menkens KA, French ED, Bilsky EJ, Porreca F. Cocaine self-administration and naltrindole, a delta-selective opioid antagonist Neuroreport. 6: 1409-1412. PMID 7488736  1
1995 Nath C, Patnaik GK, Haq W, Mathur KB, Srimal RC, Dhawan BN, Porreca F. Novel met-enkephalin analogue: a potent systemic mu agonist antinociceptive agent. Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 31: 269-73. PMID 7479523 DOI: 10.1016/1043-6618(95)80031-X  1
1995 Misicka A, Lipkowski AW, Slaninova J, Davis P, Yamamura HI, Porreca F, Hruby VJ. The synthesis and opioid receptor binding affinities of analogues of dermorphin and its N-terminal tetrapeptide fragment with dibasic acids in position 2. Life Sciences. 57: 1633-40. PMID 7475903 DOI: 10.1016/0024-3205(95)02142-6  1
1995 Misicka A, Lipkowski AW, Stropova D, Davis P, Porreca F, Yamamura HI, Hruby VJ. Amino acids with amphiphilic side chains: Deltorphin analogues with Phe3 replaced by all β-hydroxyphenylalanine diastereoisomers Letters in Peptide Science. 2: 203-205. DOI: 10.1007/BF00119153  1
1995 Lipkowski AW, Misicka A, Porreca F, Davis P, Yamamura HI, Stropova D, Hruby VJ. Benzomorphan alkaloids: Natural peptidomimetics of opioid peptide pharmacophores Letters in Peptide Science. 2: 177-181. DOI: 10.1007/BF00119147  1
1994 Bartosz-Bechowski H, Davis P, Zalewska T, Slaninova J, Porreca F, Yamamura HI, Hruby VJ. Cyclic enkephalin analogs with exceptional potency at peripheral delta opioid receptors. Journal of Medicinal Chemistry. 37: 146-50. PMID 8289188 DOI: 10.1021/JM00027A018  1
1994 Misicka A, Lipkowski AW, Horvath R, Davis P, Yamamura HI, Porreca F, Hruby VJ. Design of cyclic deltorphins and dermenkephalins with a disulfide bridge leads to analogues with high selectivity for delta-opioid receptors. Journal of Medicinal Chemistry. 37: 141-5. PMID 8289187 DOI: 10.1021/JM00027A017  1
1994 Haaseth RC, Horan PJ, Bilsky EJ, Davis P, Zalewska T, Slaninova J, Yamamura HI, Weber SJ, Davis TP, Porreca F. [L-Ala3]DPDPE: a new enkephalin analog with a unique opioid receptor activity profile. Further evidence of delta-opioid receptor multiplicity. Journal of Medicinal Chemistry. 37: 1572-7. PMID 8201592 DOI: 10.1021/JM00037A007  1
1994 Vanderah T, Takemori AE, Sultana M, Portoghese PS, Mosberg HI, Hruby VJ, Haaseth RC, Matsunaga TO, Porreca F. Interaction of [D-Pen2,D-Pen5]enkephalin and [D-Ala2,Glu4]deltorphin with delta-opioid receptor subtypes in vivo. European Journal of Pharmacology. 252: 133-7. PMID 8157053 DOI: 10.1016/0014-2999(94)90588-6  1
1994 Lai J, Bilsky EJ, Rothman RB, Porreca F. Treatment with antisense oligodeoxynucleotide to the opioid δ receptor selectively inhibits δ<inf>2</inf>-agonist antinociception Neuroreport. 5: 1049-1052. PMID 8080957 DOI: 10.1097/00001756-199405000-00008  1
1994 Polt R, Porreca F, Szabò LZ, Bilsky EJ, Davis P, Abbruscato TJ, Davis TP, Harvath R, Yamamura HI, Hruby VJ. Glycopeptide enkephalin analogues produce analgesia in mice: evidence for penetration of the blood-brain barrier. Proceedings of the National Academy of Sciences of the United States of America. 91: 7114-8. PMID 8041755 DOI: 10.1073/pnas.91.15.7114  1
1994 Calderon SN, Rothman RB, Porreca F, Flippen-Anderson JL, McNutt RW, Xu H, Smith LE, Bilsky EJ, Davis P, Rice KC. Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4-[(alpha R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3- methoxybenzyl]-N,N-diethylbenzamide (SNC 80): a highly selective, nonpeptide delta opioid receptor agonist. Journal of Medicinal Chemistry. 37: 2125-8. PMID 8035418 DOI: 10.1021/JM00040A002  0.88
1994 Qian X, Kövér KE, Shenderovich MD, Lou BS, Misicka A, Zalewska T, Horváth R, Davis P, Bilsky EJ, Porreca F, Yamamura HI, Hruby VJ. Newly discovered stereochemical requirements in the side-chain conformation of δ opioid agonists for recognizing opioid δ receptors Journal of Medicinal Chemistry. 37: 1746-1757. PMID 8021915 DOI: 10.1021/JM00038A004  1
1994 Bilsky EJ, Bernstein RN, Pasternak GW, Hruby VJ, Patel D, Porreca F, Lai J. Selective inhibition of [D-ALA2, GLU4]deltrophin antinociception by supraspinal, but not spinal, administration of an antisense oligodeoxynucleotide to an opioid delta receptor Life Sciences. 55: PL37-PL43. PMID 8015351 DOI: 10.1016/0024-3205(94)90110-4  1
1994 Mosberg HI, Lomize AL, Wang C, Kroona H, Heyl DL, Sobczyk-Kojiro K, Ma W, Mousigian C, Porreca F. Development of a model for the delta opioid receptor pharmacophore. 1. Conformationally restricted Tyr1 replacements in the cyclic delta receptor selective tetrapeptide Tyr-c[D-Cys-Phe-D-Pen]OH (JOM-13). Journal of Medicinal Chemistry. 37: 4371-83. PMID 7996549 DOI: 10.1021/jm00051a015  1
1994 Wild KD, Porreca F, Yamamura HI, Raffa RB. Differentiation of receptor subtypes by thermodynamic analysis: application to opioid delta receptors. Proceedings of the National Academy of Sciences of the United States of America. 91: 12018-21. PMID 7991576 DOI: 10.1073/pnas.91.25.12018  1
1994 Craft RM, Porreca F. Temporal parameters of desensitization to intravesical resiniferatoxin in the rat. Physiology & Behavior. 56: 479-85. PMID 7972397 DOI: 10.1016/0031-9384(94)90290-9  1
1994 Meyer JP, Collins N, Lung FD, Davis P, Zalewska T, Porreca F, Yamamura HI, Hruby VJ. Design, synthesis, and biological properties of highly potent cyclic dynorphin A analogues. Analogues cyclized between positions 5 and 11. Journal of Medicinal Chemistry. 37: 3910-7. PMID 7966152 DOI: 10.1021/JM00049A010  1
1994 Craft RM, Porreca F. Tetracaine attenuates irritancy without attenuating desensitization produced by intravesical resiniferatoxin in the rat. Pain. 57: 351-9. PMID 7936713 DOI: 10.1016/0304-3959(94)90011-6  1
1994 Connelly CD, Martinez RP, Schupsky JJ, Porreca F, Raffa RB. Etonitazene-induced antinociception in μ1 opioid receptor deficient CXBK mice: Evidence for a role for μ2 receptors in supraspinal antinociception Life Sciences. 54. PMID 7910928 DOI: 10.1016/0024-3205(94)90037-X  1
1994 Ossipov MH, Kovelowski CJ, Vanderah T, Porreca F. Naltrindole, an opioid δ antagonist, blocks the enhancement of morphine-antinociception induced by a CCKB antagonist in the rat Neuroscience Letters. 181: 9-12. PMID 7898778 DOI: 10.1016/0304-3940(94)90548-7  1
1994 Lai J, Rothman RB, Lentes KU, Ma SW, Doble A, Zhu RH, Porreca F. Pharmacological characterization of the cloned kappa opioid receptor as a kappa<inf>1b</inf> subtype Neuroreport. 5: 2161-2164. PMID 7865767 DOI: 10.1097/00001756-199410270-00043  1
1994 Misicka A, Lipkowski AW, Horvath R, Davis P, Porreca F, Yamamura HI, Hruby VJ. Delta opioid receptor selective ligands; DPLPE-deltorphin chimeric peptide analogues. International Journal of Peptide and Protein Research. 44: 80-4. PMID 7718035 DOI: 10.1111/J.1399-3011.1994.TB00407.X  1
1994 Vanderah TW, Lai J, Yamamura HI, Porreca F. Antisense oligodeoxynucleotide to the CCKB receptor produces naltrindole- and [Leu5]enkephalin antiserum-sensitive enhancement of morphine antinociception. Neuroreport. 5: 2601-5. PMID 7696612  1
1994 Rao RK, Levenson S, Fang SN, Hruby VJ, Yamamura HI, Porreca F. Role of substance P in the regulation of ion transport by CCKA and CCKB receptors in mouse ileum. Annals of the New York Academy of Sciences. 713: 420-1. PMID 7514373 DOI: 10.1111/j.1749-6632.1994.tb44113.x  1
1994 Mayfield KP, Lai J, Porreca F. Selective upregulation of opioid delta receptors in NG 108-15 cells by treatment with cobalt: Possible hypoxic regulation Regulatory Peptides. 54: 183-184. DOI: 10.1016/0167-0115(94)90451-0  1
1994 Lai J, Bilsky EJ, Bernstein RN, Rothman RB, Pasternak GW, Porreca F. Antisense oligodeoxynucleotide to the cloned delta opioid receptor selectively inhibits supraspinal, but not spinal, antinociceptive effects of [D-Ala2, Glu4]deltorphin Regulatory Peptides. 54: 159-160. DOI: 10.1016/0167-0115(94)90439-1  1
1994 Hubbell C, Amendola C, Menkens K, Porreca F. Delta opioidergic processes and rats' reactivity to addicting stimulants Regulatory Peptides. 54: 125-126. DOI: 10.1016/0167-0115(94)90421-9  1
1994 Hruby VJ, Collins N, Lung FD, Meyer JP, Davis TP, Yamamura HI, Porreca F. Design of peptides and peptidomimetics for delta and kappa opioid receptor subtypes Regulatory Peptides. 54: 123-124. DOI: 10.1016/0167-0115(94)90420-0  1
1994 Wang Z, Bilsky EJ, Porreca F, Sadée W. Accelerated communciation: Constitutive μ opioid receptor activation as a regulatory mechanism underlying narcotic tolerance and dependence Life Sciences. 54. DOI: 10.1016/0024-3205(94)90022-1  1
1993 Raffa RB, Wild KD, Mosberg HI, Porreca F. Thermodynamic parameters for [D-Pen2,5]enkephalin at δ-opioid receptors in the mouse isolated vas deferens European Journal of Pharmacology: Molecular Pharmacology. 244: 231-238. PMID 8384567 DOI: 10.1016/0922-4106(93)90148-3  1
1993 Reid LD, Hubbell CL, Glaccum MB, Bilsky EJ, Portoghese PS, Porreca F. Naltrindole, an opioid delta receptor antagonist, blocks cocaine-induced facilitation of responding for rewarding brain stimulation Life Sciences. 52: PL67-PL71. PMID 8382329 DOI: 10.1016/0024-3205(93)90084-G  1
1993 Mosberg HI, Porreca F. A model for the structural basis of delta 2-opioid receptor selectivity Nida Research Monograph. 134: 268-280. PMID 8289883  1
1993 Wild KD, Fang L, McNutt RW, Chang KJ, Toth G, Borsodi A, Yamamura HI, Porreca F. Binding of BW 373U86, a non-peptidic delta opioid receptor agonist, is not regulated by guanine nucleotides and sodium. European Journal of Pharmacology. 246: 289-92. PMID 8223952 DOI: 10.1016/0922-4106(93)90044-A  1
1993 Horan PJ, Porreca F. Lack of cross-tolerance between U69,593 and bremazocine suggest κ-opioid receptor multiplicity in mice European Journal of Pharmacology. 239: 93-98. PMID 8223918 DOI: 10.1016/0014-2999(93)90980-V  1
1993 Kawasaki AM, Knapp RJ, Kramer TH, Walton A, Wire WS, Hashimoto S, Yamamura HI, Porreca F, Burks TF, Hruby VJ. Design and synthesis of highly potent and selective cyclic dynorphin A analogs. 2. New analogs. Journal of Medicinal Chemistry. 36: 750-7. PMID 8096246 DOI: 10.1021/JM00058A012  1
1993 Kawasaki AM, Knapp RJ, Walton A, Wire WS, Zalewska T, Yamamura HI, Porreca F, Burks TF, Hruby VJ. Syntheses, opioid binding affinities, and potencies of dynorphin A analogues substituted in positions, 1, 6, 7, 8 and 10. International Journal of Peptide and Protein Research. 42: 411-9. PMID 7906258 DOI: 10.1111/J.1399-3011.1993.TB00148.X  1
1993 Craft RM, Carlisi VJ, Mattia A, Herman RM, Porreca F. Behavioral characterization of the excitatory and desensitizing effects of intravesical capsaicin and resiniferatoxin in the rat. Pain. 55: 205-15. PMID 7508591 DOI: 10.1016/0304-3959(93)90149-J  1
1993 Hristova-Kazmierski MK, Horan P, Davis P, Yamamura HI, Kramer T, Horvath R, Kazmierski WM, Porreca F, Hruby VJ. A new approach to enhance bioavailability of biologically active peptides: conjugation of a δ opioid agonist to β-cyclodextrin Bioorganic and Medicinal Chemistry Letters. 3: 831-834. DOI: 10.1016/S0960-894X(00)80675-7  1
1992 Craft RM, Porreca F. Treatment parameters of desensitization to capsaicin. Life Sciences. 51: 1767-75. PMID 1435085 DOI: 10.1016/0024-3205(92)90046-R  1
1992 Menkens K, Bilsky EJ, Wild KD, Portoghese PS, Reid LD, Porreca F. Cocaine place preference is blocked by the δ-opioid receptor antagonist, naltrindole European Journal of Pharmacology. 219: 345-346. PMID 1425962 DOI: 10.1016/0014-2999(92)90319-Y  1
1992 Raffa RB, Martinez RP, Porreca F. Lack of antinociceptive efficacy of intracerebroventricular [D-Ala2,Glu4]deltorphin, but not [D-Pen2,D-Pen5]enkephalin, in the μ-opioid receptor deficient CXBX mouse European Journal of Pharmacology. 216: 453-456. PMID 1330585 DOI: 10.1016/0014-2999(92)90446-B  1
1992 Yamamura MS, Horvath R, Toth G, Otvos F, Malatynska E, Knapp RJ, Porreca F, Hruby VJ, Yamamura HI. Characterization of [3H]naltrindole binding to delta opioid receptors in rat brain. Life Sciences. 50: PL119-24. PMID 1313133 DOI: 10.1016/0024-3205(92)90464-Z  1
1991 Rapaka RS, Porreca F. Development of delta opioid peptides as nonaddicting analgesics. Pharmaceutical Research. 8: 1-8. PMID 1849640 DOI: 10.1023/A:1015809702296  1
1991 Rothman RB, Bykov V, Mahboubi A, Long JB, Jiang Q, Porreca F, de Costa BR, Jacobson AE, Rice KC, Holaday JW. Interaction of beta-funaltrexamine with [3H]cycloFOXY binding in rat brain: further evidence that beta-FNA alkylates the opioid receptor complex. Synapse (New York, N.Y.). 8: 86-99. PMID 1652797 DOI: 10.1002/syn.890080203  1
1991 Mattia A, Vanderah T, Mosberg HI, Omnaas JR, Bowen WD, Porreca F. Pharmacological characterization of [D-Ala2,Leu5,Ser6]enkephalin (DALES): antinociceptive actions at the δnon-complexed-opioid receptor European Journal of Pharmacology. 192: 371-375. PMID 1647317 DOI: 10.1016/0014-2999(91)90227-H  1
1991 Wild KD, Vanderah T, Mosberg HI, Porreca F. Opioid δ receptor subtypes are associated with different potassium channels European Journal of Pharmacology. 193: 135-136. PMID 1646729 DOI: 10.1016/0014-2999(91)90215-C  1
1990 Porreca F, Qi Jiang, Tallarida RJ. Modulation of morphine antinociception by peripheral [Leu5]enkephalin: a synergistic interaction European Journal of Pharmacology. 179: 463-468. PMID 2364995 DOI: 10.1016/0014-2999(90)90190-H  1
1990 Sheldon RJ, Qi JA, Porreca F, Fisher LA. Gastrointestinal motor effects of corticotropin-releasing factor in mice. Regulatory Peptides. 28: 137-51. PMID 2343161 DOI: 10.1016/0167-0115(90)90013-M  1
1990 Wheeler-Aceto H, Porreca F, Cowan A. The rat paw formalin test: comparison of noxious agents Pain. 40: 229-238. PMID 2308768 DOI: 10.1016/0304-3959(90)90073-M  1
1990 Qi J, Mosberg HI, Porreca F. Selective modulation of morphine antinociception, but not development of tolerance, by δ receptor agonists European Journal of Pharmacology. 186: 137-141. PMID 2178093 DOI: 10.1016/0014-2999(90)94071-5  1
1990 Jiang Q, Mosberg HI, Porreca F. Antinociceptive effects of [D-Ala2]deltorphin II, a highly selective δ agonist in vivo Life Sciences. 47. PMID 2170791 DOI: 10.1016/0024-3205(90)90545-3  1
1990 Porreca F, LoPresti D, Ward SJ. Opioid agonist affinity in the guinea-pig ileum and mouse vas deferens. European Journal of Pharmacology. 179: 129-39. PMID 2163849 DOI: 10.1016/0014-2999(90)90410-8  1
1989 Porreca F, Burks TF, Sheldon RJ. Central and peripheral visceral effects of bombesin Annals of the New York Academy of Sciences. 547: 194-203. PMID 3239887 DOI: 10.1111/j.1749-6632.1988.tb23887.x  1
1989 Tallarida RJ, Porreca F, Cowan A. Statistical analysis of drug-drug and site-site interactions with isobolograms Life Sciences. 45: 947-961. PMID 2677570 DOI: 10.1016/0024-3205(89)90148-3  1
1989 Raffa RB, Vaught JL, Porreca F. Can equal pA2 values be compatible with receptor differences? Trends in Pharmacological Sciences. 10: 183-185. PMID 2667226 DOI: 10.1016/0165-6147(89)90234-4  1
1989 Davis TP, Gillespie TJ, Porreca F. Peptide fragments derived from the beta-chain of hemoglobin (hemorphins) are centrally active in vivo. Peptides. 10: 747-51. PMID 2587417 DOI: 10.1016/0196-9781(89)90107-1  1
1989 Heyman JS, Jiang Q, Rothman RB, Mosberg HI, Porreca F. Modulation of μ-mediated antinociception by δ agonists: characterization with antagonists European Journal of Pharmacology. 169: 43-52. PMID 2557223 DOI: 10.1016/0014-2999(89)90815-7  1
1989 Heyman JS, Vaught JL, Mosberg HI, Haaseth RC, Porreca F. Modulation of μ-mediated antinociception by δ agonists in the mouse: selective potentiation of morphine and normorphine by [D-Pen2, D-Pen5]enkephalin European Journal of Pharmacology. 165: 1-10. PMID 2548877 DOI: 10.1016/0014-2999(89)90764-4  1
1989 Raffa RB, Porreca F. Thermodynamic analysis of the drug-receptor interaction Life Sciences. 44: 245-258. PMID 2536880 DOI: 10.1016/0024-3205(89)90182-3  1
1988 Murray CW, Porreca F, Cowan A. Methodological refinements to the mouse paw formalin test. An animal model of tonic pain. Journal of Pharmacological Methods. 20: 175-86. PMID 3221681 DOI: 10.1016/0160-5402(88)90078-2  1
1988 Heyman JS, Vaught JL, Raffa RB, Porreca F. Can supraspinal delta-opioid receptors mediate antinociception? Trends in Pharmacological Sciences. 9: 134-8. PMID 2854316 DOI: 10.1016/0165-6147(88)90195-2  0.56
1988 Burks TF, Fox DA, Hirning LD, Shook JE, Porreca F. Regulation of gastrointestinal function by multiple opioid receptors. Life Sciences. 43: 2177-81. PMID 2850428 DOI: 10.1016/0024-3205(88)90410-9  1
1988 Jiang Q, Sheldon RJ, Porreca F. Sites of clonidine action to inhibit gut propulsion in mice: Demonstration of a central component Gastroenterology. 95: 1265-1271. PMID 2844620 DOI: 10.1016/0016-5085(88)90360-5  1
1988 Sheldon RJ, Nunan L, Porreca F. U50,488H differentially antagonizes the bladder effects of μ agonists at spinal sites European Journal of Pharmacology. 146: 229-235. PMID 2836207 DOI: 10.1016/0014-2999(88)90297-X  1
1987 Jiang Q, Sheldon RJ, Porreca F. A comparison of the central gastrointestinal antitransit effects of morphine and bombesin in the mouse Life Sciences. 41: 2455-2461. PMID 3683084 DOI: 10.1016/0024-3205(87)90671-0  1
1987 Porreca F, Heyman JS, Mosberg HI, Omnaas JR, Vaught JL. Role of mu and delta receptors in the supraspinal and spinal analgesic effects of [D-Pen2, D-Pen5]Enkephalin in the mouse Journal of Pharmacology and Experimental Therapeutics. 241: 393-400. PMID 3033214 DOI: 10.1016/0304-3959(88)90102-9  1
1987 Porreca F, Nunan L, Kazmierski W, Hruby VJ. Effects of a novel opioid peptide antagonist on rat bladder motility in vivo Peptides. 8: 625-632. PMID 2888099 DOI: 10.1016/0196-9781(87)90036-2  1
1987 Porreca F, Tortella FC. Differential antagonism of mu agonists by U50,488H in the rat Life Sciences. 41: 2511-2516. PMID 2824958 DOI: 10.1016/0024-3205(87)90435-8  1
1987 Heyman JS, Mulvaney SA, Mosberg HI, Porreca F. Opioid delta-receptor involvement in supraspinal and spinal antinociception in mice. Brain Research. 420: 100-8. PMID 2823970 DOI: 10.1016/0006-8993(87)90244-7  1
1986 Raffa RB, Porreca F. Evidence for a role of conditioning in the development of tolerance to morphine-induced inhibition of gastrointestinal transit in rats Neuroscience Letters. 67: 229-232. PMID 3737009 DOI: 10.1016/0304-3940(86)90313-7  1
1986 Heyman JS, Koslo RJ, Mosberg HI, Tallarida RJ, Porreca F. Estimation of the affinity of naloxone at supraspinal and spinal opioid receptors in vivo: Studies with receptor selective agonists Life Sciences. 39: 1795-1803. PMID 3022095 DOI: 10.1016/0024-3205(86)90099-8  1
1986 Spencer RL, Deupree D, Hsiao S, Mosberg HI, Hruby V, Burks TF, Porreca F. Centrally-administered opioid selective agonists inhibit drinking in the rat Pharmacology, Biochemistry and Behavior. 25: 77-82. PMID 2875475 DOI: 10.1016/0091-3057(86)90233-9  1
1986 Raffa RB, Heyman J, Porreca F. Intrathecal FMRFamide (Phe-Met-Arg-Phe-NH2) induces excessive grooming behavior in mice Neuroscience Letters. 65: 94-98. PMID 2422608 DOI: 10.1016/0304-3940(86)90126-6  1
1986 Porreca F, Galligan JJ, Burks TF. Central opioid receptor involvement in gastrointestinal motility Trends in Pharmacological Sciences. 7: 104-107. DOI: 10.1016/0165-6147(86)90274-9  1
1985 Porreca F, Fulginiti JT, Burks TF. Bombesin stimulates small intestinal motility after intracerebroventricular administration to rats European Journal of Pharmacology. 114: 167-173. PMID 4043224 DOI: 10.1016/0014-2999(85)90624-7  1
1985 Davis TP, Porreca F, Burks TF, Dray A. The proenkephalin A fragment, peptide E: central processing and CNS activity in vivo. European Journal of Pharmacology. 111: 177-83. PMID 2990950 DOI: 10.1016/0014-2999(85)90754-X  1
1985 Hirning LD, Mosberg HI, Hurst R, Hruby VJ, Burks TF, Porreca F. Studies in vitro with ICI 174, 864, [D-Pen2, D-Pen5]-enkephalin (DPDPE) and [D-Ala2, NMePhe4, Gly-ol]-enkephalin (DAGO) Neuropeptides. 5: 383-386. PMID 2987739 DOI: 10.1016/0143-4179(85)90034-4  1
1985 Cowan A, Zhu XZ, Porreca F. Studies in vivo with ICI 174864 and [D-Pen2, D-Pen5]enkephalin Neuropeptides. 5: 311-314. PMID 2987731 DOI: 10.1016/0143-4179(85)90015-0  1
1985 Hirning LD, Porreca F, Burks TF. μ, but not κ, opioid agonists induce contractions of the canine small intestine ex vivo European Journal of Pharmacology. 109: 49-54. PMID 2986990 DOI: 10.1016/0014-2999(85)90538-2  1
1985 Porreca F, Burks TF, Koslo RJ. III. Centrally-mediated bombesin effects on gastrointestinal motility Life Sciences. 37: 125-134. PMID 2409425 DOI: 10.1016/0024-3205(85)90415-1  1
1984 Porreca F, Dray A. Motilin acts within the CNS to inhibit urinary bladder contractions Life Sciences. 34: 2577-2581. PMID 6547500 DOI: 10.1016/0024-3205(84)90043-2  1
1983 Porreca F, Mosberg HI, Hurst R, Hruby VJ, Burks TF. A comparison of the analgesic and gastrointestinal transit effects of [D-Pen2, L-Cys5] enkephalin after intracerebroventricular and intrathecal administration to mice Life Sciences. 33: 457-460. PMID 6689355 DOI: 10.1016/0024-3205(83)90540-4  1
1983 Galligan JJ, Porreca F, Burks TF. Footshock produces analgesia but no gastrointestinal motility effects in the rat. Life Sciences. 33: 473-5. PMID 6664227 DOI: 10.1016/0024-3205(83)90544-1  1
1983 Porreca F, Cowan A, Raffa RB, Tallarida RJ. Ketazocines and morphine: Effects on gastrointestinal transit after central and peripheral administration Life Sciences. 32: 1785-1790. PMID 6339861 DOI: 10.1016/0024-3205(83)90843-3  1
1983 Galligan JJ, Porreca F, Burks TF. Dissociation of analgesic and gastrointestinal effects of electroconvulsive shock-released opioids. Brain Research. 271: 354-7. PMID 6311331 DOI: 10.1016/0006-8993(83)90301-3  1
1983 Burks TF, Galligan JJ, Porreca F. Gastrointestinal drug receptors. Journal of Clinical Gastroenterology. 5: 29-36. PMID 6140283 DOI: 10.1097/00004836-198312001-00004  1
1983 Porreca F, Filla A, Burks TF. Studies in vivo with dynorphin-(1-9): Analgesia but not gastrointestinal effects following intrathecal administration to mice European Journal of Pharmacology. 91: 291-294. PMID 6137394 DOI: 10.1016/0014-2999(83)90481-8  1
1982 Raffa RB, Porreca F, Cowan A, Tallarida RJ. Extraction and measurement of morphine: Correlation of brain level and s.c. dose in drug-naive and morphine-tolerant rats Life Sciences. 31: 2299-2302. PMID 7162345 DOI: 10.1016/0024-3205(82)90142-4  1
1982 Porreca F, Filla A, Burks TF. Spinal cord-mediated opiate effects on gastrointestinal transit in mice European Journal of Pharmacology. 86: 135-136. PMID 7160430 DOI: 10.1016/0014-2999(82)90412-5  1
1982 Tallarida RJ, Robinson MJ, Porreca F, Cowan A. Estimation of the dissociation constant of naloxone in the naive and morphine-tolerant guinea-pig isolated ileum: analysis by the constrained Schild plot. Life Sciences. 31: 1691-4. PMID 7154829 DOI: 10.1016/0024-3205(82)90187-4  0.52
1982 Porreca F, Cowan A, Tallarida RJ. Differentiation of apomorphine from bromocriptine, piribidel and TRH by chronic administration in rats Psychopharmacology. 76: 70-74. PMID 6805012 DOI: 10.1007/BF00430759  1
1982 Porreca F, Cowan A, Raffa RB, Tallarida RJ. Estimation in vivo of the receptor constants of morphine in naive and morphine-tolerant rats Life Sciences. 31: 2355-2358. PMID 6298527 DOI: 10.1016/0024-3205(82)90155-2  1
1982 Porreca F, Raffa RB, Cowan A, Tallarida RJ. A comparison of the receptor constants of morphine and ethylketocyclazocine for analgesia and inhibition of gastrointestinal transit in the rat Life Sciences. 31: 1955-1961. PMID 6294424 DOI: 10.1016/0024-3205(82)90034-0  1
1982 Porreca F, Cowan A, Raffa RB, Tallarida RJ. Tolerance and cross-tolerance studies with morphine and ethylketocyclazocine Journal of Pharmacy and Pharmacology. 34: 666-667. PMID 6128391 DOI: 10.1111/j.2042-7158.1982.tb04698.x  1
1982 Porreca F, Cowan A, Raffa RB, Tallarida RJ. On the criteria for classifying opiate agonists in rats Journal of Pharmacy and Pharmacology. 34: 525-526. PMID 6126567 DOI: 10.1111/j.2042-7158.1982.tb04780.x  1
1981 Porreca F, Cowan A, Tallarida RJ. Time course of antagonism of morphine antinociception by intracerebroventricularly administered naloxone in the rat European Journal of Pharmacology. 76: 55-59. PMID 7318922 DOI: 10.1016/0014-2999(81)90008-X  1
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