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Edward Harhaj - Publications

Affiliations: 
Microbiology and Immunology (Medicine) University of Miami, Coral Gables, FL 
Area:
Microbiology Biology
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59 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Kazzaz SA, Shaikh KA, White J, Zhou Q, Powell WH, Harhaj EW. Phosphorylation of aryl hydrocarbon receptor interacting protein by TBK1 negatively regulates IRF7 and the type I interferon response. The Journal of Biological Chemistry. 105525. PMID 38043800 DOI: 10.1016/j.jbc.2023.105525  0.452
2022 Madugula KK, Joseph J, DeMarino C, Ginwala R, Teixeira V, Khan ZK, Sales D, Wilson S, Kashanchi F, Rushing AW, Lemasson I, Harhaj EW, Janakiram M, Ye BH, Jain P. Regulation of Human T-cell Leukemia Virus type 1 antisense promoter by Myocyte Enhancer Factor-2C in the context of Adult T-cell leukemia and lymphoma. Haematologica. PMID 35615924 DOI: 10.3324/haematol.2021.279542  0.369
2020 Mohanty S, Han T, Choi YB, Lavorgna A, Zhang J, Harhaj EW. The E3/E4 ubiquitin conjugation factor UBE4B interacts with and ubiquitinates the HTLV-1 Tax oncoprotein to promote NF-κB activation. Plos Pathogens. 16: e1008504. PMID 33362245 DOI: 10.1371/journal.ppat.1008504  0.411
2020 Harhaj EW, Shembade N. Lymphotropic Viruses: Chronic Inflammation and Induction of Cancers. Biology. 9. PMID 33182552 DOI: 10.3390/biology9110390  0.466
2020 Mohanty S, Harhaj EW. Mechanisms of Oncogenesis by HTLV-1 Tax. Pathogens (Basel, Switzerland). 9. PMID 32645846 DOI: 10.3390/pathogens9070543  0.432
2018 Choi YB, Choi Y, Harhaj EW. Peroxisomes support human herpesvirus 8 latency by stabilizing the viral oncogenic protein vFLIP via the MAVS-TRAF complex. Plos Pathogens. 14: e1007058. PMID 29746593 DOI: 10.1371/journal.ppat.1007058  0.446
2018 Harhaj EW, Giam CZ. NF-κB signaling mechanisms in HTLV-1-induced adult T-cell leukemia/lymphoma. The Febs Journal. PMID 29722927 DOI: 10.1111/febs.14492  0.418
2017 Mao R, Yang R, Chen X, Harhaj EW, Wang X, Fan Y. Regnase-1, a rapid response ribonuclease regulating inflammation and stress responses. Cellular & Molecular Immunology. PMID 28194024 DOI: 10.1038/cmi.2016.70  0.319
2016 Choi YB, Shembade N, Parvatiyar K, Balachandran S, Harhaj EW. TAX1BP1 restrains virus-induced apoptosis by facilitating Itch-mediated degradation of the mitochondrial adaptor MAVS. Molecular and Cellular Biology. PMID 27736772 DOI: 10.1128/MCB.00422-16  0.748
2015 Zhou Q, Lavorgna A, Bowman M, Hiscott J, Harhaj EW. Aryl Hydrocarbon Receptor Interacting Protein Targets IRF7 to Suppress Antiviral Signaling and the Induction of Type I Interferon. The Journal of Biological Chemistry. 290: 14729-39. PMID 25911105 DOI: 10.1074/Jbc.M114.633065  0.546
2015 Jain P, Lavorgna A, Sehgal M, Gao L, Ginwala R, Sagar D, Harhaj EW, Khan ZK. Myocyte enhancer factor (MEF)-2 plays essential roles in T-cell transformation associated with HTLV-1 infection by stabilizing complex between Tax and CREB. Retrovirology. 12: 23. PMID 25809782 DOI: 10.1186/s12977-015-0140-1  0.351
2015 Shembade N, Harhaj EW. Elucidating dynamic protein-protein interactions and ubiquitination in NF-κB signaling pathways. Methods in Molecular Biology (Clifton, N.J.). 1280: 283-95. PMID 25736755 DOI: 10.1007/978-1-4939-2422-6_16  0.464
2015 Hyun J, Ramos JC, Toomey N, Balachandran S, Lavorgna A, Harhaj E, Barber GN. Oncogenic human T-cell lymphotropic virus type 1 tax suppression of primary innate immune signaling pathways. Journal of Virology. 89: 4880-93. PMID 25694597 DOI: 10.1128/Jvi.02493-14  0.495
2014 Choi YB, Harhaj EW. Functional implications of mitochondrial reactive oxygen species generated by oncogenic viruses. Frontiers in Biology. 9: 423-436. PMID 25580106 DOI: 10.1007/s11515-014-1332-0  0.382
2014 Lavorgna A, Harhaj EW. Regulation of HTLV-1 tax stability, cellular trafficking and NF-κB activation by the ubiquitin-proteasome pathway. Viruses. 6: 3925-43. PMID 25341660 DOI: 10.3390/v6103925  0.374
2014 Choi YB, Harhaj EW. HTLV-1 tax stabilizes MCL-1 via TRAF6-dependent K63-linked polyubiquitination to promote cell survival and transformation. Plos Pathogens. 10: e1004458. PMID 25340740 DOI: 10.1371/journal.ppat.1004458  0.374
2013 Gao L, Harhaj EW. HSP90 protects the human T-cell leukemia virus type 1 (HTLV-1) tax oncoprotein from proteasomal degradation to support NF-κB activation and HTLV-1 replication. Journal of Virology. 87: 13640-54. PMID 24109220 DOI: 10.1128/JVI.02006-13  0.424
2013 Lavorgna A, Harhaj EW. Is there a role for ubiquitin or SUMO in human T-cell leukemia virus type 2 Tax-induced NF-κB activation? Future Virology. 8: 223-227. PMID 23730325 DOI: 10.2217/fvl.13.1  0.393
2013 Charoenthongtrakul S, Gao L, Parvatiyar K, Lee D, Harhaj EW. RING finger protein 11 targets TBK1/IKKi kinases to inhibit antiviral signaling. Plos One. 8: e53717. PMID 23308279 DOI: 10.1371/Journal.Pone.0053717  0.725
2012 Charoenthongtrakul S, Gao L, Harhaj EW. The NLRP4-DTX4 axis: a key suppressor of TBK1 and innate antiviral signaling. Cellular & Molecular Immunology. 9: 431-3. PMID 23064103 DOI: 10.1038/Cmi.2012.49  0.798
2012 Harhaj EW, Dixit VM. Regulation of NF-κB by deubiquitinases Immunological Reviews. 246: 107-124. PMID 22435550 DOI: 10.1111/J.1600-065X.2012.01100.X  0.431
2012 Shembade N, Harhaj EW. Regulation of NF-κB signaling by the A20 deubiquitinase. Cellular & Molecular Immunology. 9: 123-30. PMID 22343828 DOI: 10.1038/cmi.2011.59  0.483
2012 Lavorgna A, Harhaj EW. An RNA interference screen identifies the Deubiquitinase STAMBPL1 as a critical regulator of human T-cell leukemia virus type 1 tax nuclear export and NF-κB activation. Journal of Virology. 86: 3357-69. PMID 22258247 DOI: 10.1128/JVI.06456-11  0.378
2011 Shembade N, Harhaj EW. Outfoxing FoxO transcription factors: HTLV-1 Tax oncoprotein inactivates FoxO4 via the ubiquitin-proteasome pathway. Future Virology. 6: 1165-1168. PMID 22194775 DOI: 10.2217/fvl.11.94  0.471
2011 Gao L, Coope H, Grant S, Ma A, Ley SC, Harhaj EW. ABIN1 protein cooperates with TAX1BP1 and A20 proteins to inhibit antiviral signaling. The Journal of Biological Chemistry. 286: 36592-602. PMID 21885437 DOI: 10.1074/Jbc.M111.283762  0.595
2011 Shembade N, Pujari R, Harhaj NS, Abbott DW, Harhaj EW. The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1. Nature Immunology. 12: 834-43. PMID 21765415 DOI: 10.1038/ni.2066  0.432
2011 Charoenthongtrakul S, Zhou Q, Shembade N, Harhaj NS, Harhaj EW. Human T cell leukemia virus type 1 Tax inhibits innate antiviral signaling via NF-kappaB-dependent induction of SOCS1. Journal of Virology. 85: 6955-62. PMID 21593151 DOI: 10.1128/Jvi.00007-11  0.791
2011 Harhaj EW, Dixit VM. Deubiquitinases in the regulation of NF-κB signaling Cell Research. 21: 22-39. PMID 21119682 DOI: 10.1038/Cr.2010.166  0.436
2011 Parvatiyar K, Harhaj EW. Regulation of inflammatory and antiviral signaling by A20. Microbes and Infection / Institut Pasteur. 13: 209-15. PMID 21111841 DOI: 10.1016/J.Micinf.2010.11.003  0.748
2011 Charoenthongtrakul S, Zhou Q, Shembade N, Harhaj NS, Barber GN, Harhaj EW. HTLV-I Tax inhibits innate antiviral signaling via NF-κB-dependent induction of SOCS1 Retrovirology. 8. DOI: 10.1186/1742-4690-8-S1-A191  0.793
2011 Shembade N, Harhaj EW. The human T-cell leukemia virus type I (HTLV-I) oncoprotein Tax promotes persistent NF-κB activation by blocking the phosphorylation of the adaptor molecule TAX1BP Retrovirology. 8. DOI: 10.1186/1742-4690-8-S1-A158  0.378
2010 Shembade N, Harhaj EW. Role of post-translational modifications of HTLV-1 Tax in NF-κB activation. World Journal of Biological Chemistry. 1: 13-20. PMID 21540989 DOI: 10.4331/wjbc.v1.i1.13  0.341
2010 Parvatiyar K, Harhaj EW. Cell signaling. Anchors away for ubiquitin chains. Science (New York, N.Y.). 328: 1244-5. PMID 20522767 DOI: 10.1126/Science.1192296  0.763
2010 Parvatiyar K, Barber GN, Harhaj EW. TAX1BP1 and A20 inhibit antiviral signaling by targeting TBK1-IKKi kinases. The Journal of Biological Chemistry. 285: 14999-5009. PMID 20304918 DOI: 10.1074/Jbc.M110.109819  0.773
2010 Shembade N, Ma A, Harhaj EW. Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes. Science (New York, N.Y.). 327: 1135-9. PMID 20185725 DOI: 10.1126/Science.1182364  0.479
2009 Tao M, Scacheri PC, Marinis JM, Harhaj EW, Matesic LE, Abbott DW. ITCH K63-ubiquitinates the NOD2 binding protein, RIP2, to influence inflammatory signaling pathways. Current Biology : Cb. 19: 1255-63. PMID 19592251 DOI: 10.1016/J.Cub.2009.06.038  0.346
2009 Shembade N, Parvatiyar K, Harhaj NS, Harhaj EW. The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling. The Embo Journal. 28: 513-22. PMID 19131965 DOI: 10.1038/Emboj.2008.285  0.77
2008 Shembade N, Harhaj NS, Parvatiyar K, Copeland NG, Jenkins NA, Matesic LE, Harhaj EW. The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20. Nature Immunology. 9: 254-62. PMID 18246070 DOI: 10.1038/Ni1563  0.752
2007 Shembade N, Harhaj NS, Yamamoto M, Akira S, Harhaj EW. The human T-cell leukemia virus type 1 Tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-kappaB activation. Journal of Virology. 81: 13735-42. PMID 17942533 DOI: 10.1128/JVI.01790-07  0.419
2007 Shembade N, Harhaj NS, Liebl DJ, Harhaj EW. Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signaling. The Embo Journal. 26: 3910-22. PMID 17703191 DOI: 10.1038/sj.emboj.7601823  0.388
2007 Harhaj NS, Sun SC, Harhaj EW. Activation of NF-kappa B by the human T cell leukemia virus type I Tax oncoprotein is associated with ubiquitin-dependent relocalization of I kappa B kinase. The Journal of Biological Chemistry. 282: 4185-92. PMID 17145747 DOI: 10.1074/Jbc.M611031200  0.405
2005 Harhaj EW, Harhaj NS. Mechanisms of persistent NF-kappaB activation by HTLV-I tax. Iubmb Life. 57: 83-91. PMID 16036567 DOI: 10.1080/15216540500078715  0.432
2005 Alefantis T, Mostoller K, Jain P, Harhaj E, Grant C, Wigdahl B. Secretion of the human T cell leukemia virus type I transactivator protein tax. The Journal of Biological Chemistry. 280: 17353-62. PMID 15659397 DOI: 10.1074/Jbc.M409851200  0.466
2004 Liao G, Zhang M, Harhaj EW, Sun SC. Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation. The Journal of Biological Chemistry. 279: 26243-50. PMID 15084608 DOI: 10.1074/jbc.M403286200  0.454
2003 Barmak K, Harhaj E, Grant C, Alefantis T, Wigdahl B. Human T cell leukemia virus type I-induced disease: pathways to cancer and neurodegeneration. Virology. 308: 1-12. PMID 12706085 DOI: 10.1016/S0042-6822(02)00091-0  0.313
2003 Alefantis T, Barmak K, Harhaj EW, Grant C, Wigdahl B. Characterization of a nuclear export signal within the human T cell leukemia virus type I transactivator protein Tax. The Journal of Biological Chemistry. 278: 21814-22. PMID 12670929 DOI: 10.1074/Jbc.M211576200  0.412
2001 Xiao G, Cvijic ME, Fong A, Harhaj EW, Uhlik MT, Waterfield M, Sun SC. Retroviral oncoprotein tax induces processing of NF-κB2/p100 in T cells: Evidence for the involvement of IKKα Embo Journal. 20: 6805-6815. PMID 11726516 DOI: 10.1093/Emboj/20.23.6805  0.44
2000 Sun SC, Harhaj EW, Xiao G, Good L. Activation of I-κB kinase by the HTLV type 1 Tax protein: Mechanistic insights into the adaptor function of IKKγ Aids Research and Human Retroviruses. 16: 1591-1596. PMID 11080796 DOI: 10.1089/08892220050193001  0.403
2000 Xiao G, Harhaj EW, Sun SC. Domain-specific interaction with the IκB kinase (IKK) regulatory subunit IKKγ is an essential step in tax-mediated activation of IKK Journal of Biological Chemistry. 275: 34060-34067. PMID 10906125  0.389
2000 Harhaj EW, Good L, Xiao G, Uhlik M, Cvijic ME, Rivera-Walsh I, Sun SC. Somatic mutagenesis studies of NF-κB signaling in human T cells: Evidence for an essential role of IKKγ, in NP-κB activation by T-cell costimulatory signals and HTLV-I Tax protein Oncogene. 19: 1448-1456. PMID 10723136 DOI: 10.1038/sj.onc.1203445  0.394
2000 Harhaj EW, Sun SC. Regulation of RelA subcellular localization by a putative nuclear export signal and p50. Molecular and Cellular Biology. 19: 7088-95. PMID 10490645 DOI: 10.1128/Mcb.19.10.7088  0.346
1999 Harhaj EW, Sun SC. IKKγ serves as a docking subunit of the IκB kinase (IKK) and mediates interaction of IKK with the human T-cell leukemia virus tax protein Journal of Biological Chemistry. 274: 22911-22914. PMID 10438454 DOI: 10.1074/jbc.274.33.22911  0.406
1998 Harhaj EW, Sun SC. IkappaB kinases serve as a target of CD28 signaling. The Journal of Biological Chemistry. 273: 25185-90. PMID 9737979 DOI: 10.1074/jbc.273.39.25185  0.34
1998 Rivera I, Harhaj EW, Sun SC. Involvement of NF-AT in type I human T-cell leukemia virus tax-mediated fas ligand promoter transactivation Journal of Biological Chemistry. 273: 22382-22388. PMID 9712859 DOI: 10.1074/jbc.273.35.22382  0.386
1998 Uhlik M, Good L, Xiao G, Harhaj EW, Zandi E, Karin M, Sun SC. NF-κB-inducing kinase and IκB kinase participate in human T-cell leukemia virus I tax-mediated NF-κB activation Journal of Biological Chemistry. 273: 21132-21136. PMID 9694868 DOI: 10.1074/Jbc.273.33.21132  0.437
1997 Maggirwar SB, Harhaj EW, Sun SC. Regulation of the interleukin-2 CD28-responsive element by NF-ATp and various NF-kappaB/Rel transcription factors. Molecular and Cellular Biology. 17: 2605-14. PMID 9111330 DOI: 10.1128/Mcb.17.5.2605  0.3
1997 Harhaj EW, Sun SC. The serine/threonine phosphatase inhibitor calyculin A induces rapid degradation of IkappaBbeta. Requirement of both the N- and C-terminal sequences. The Journal of Biological Chemistry. 272: 5409-12. PMID 9038140 DOI: 10.1074/jbc.272.9.5409  0.341
1997 Good L, Maggirwar SB, Harhaj EW, Sun SC. Constitutive dephosphorylation and activation of a member of the nuclear factor of activated T cells, NF-AT1, in Tax-expressing and type I human T-cell leukemia virus-infected human T cells. The Journal of Biological Chemistry. 272: 1425-8. PMID 8999806 DOI: 10.1074/Jbc.272.3.1425  0.316
1996 Harhaj EW, Maggirwar SB, Good L, Sun SC. CD28 mediates a potent costimulatory signal for rapid degradation of IkappaBbeta which is associated with accelerated activation of various NF-kappaB/Rel heterodimers. Molecular and Cellular Biology. 16: 6736-43. PMID 8943328 DOI: 10.1128/Mcb.16.12.6736  0.332
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