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Tony Yaksh - Publications

Affiliations: 
University of California, San Diego, La Jolla, CA 
Area:
pain, pharmacology
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Year Citation  Score
2024 Hullugundi SK, Dolkas J, Chernov AV, Yaksh TL, Eddinger KA, Angert M, Catroli GF, Strongin AY, Dougherty PM, Li Y, Quehenberger O, Armando A, Shubayev VI. Cholesterol-dependent LXR transcription factor activity represses pronociceptive effects of estrogen in sensory neurons and pain induced by myelin basic protein fragments. Brain, Behavior, & Immunity - Health. 38: 100757. PMID 38590761 DOI: 10.1016/j.bbih.2024.100757  0.323
2023 Lund H, Hunt MA, Kurtović Z, Sandor K, Kägy PB, Fereydouni N, Julien A, Göritz C, Vazquez-Liebanas E, Andaloussi Mäe M, Jurczak A, Han J, Zhu K, Harris RA, Lampa J, ... ... Yaksh TL, et al. CD163+ macrophages monitor enhanced permeability at the blood-dorsal root ganglion barrier. The Journal of Experimental Medicine. 221. PMID 38117255 DOI: 10.1084/jem.20230675  0.505
2023 Lubejko ST, Livrizzi G, Patel J, Yung JC, Yaksh TL, Banghart MR. Inputs to the locus coeruleus from the periaqueductal gray and rostroventral medulla shape opioid-mediated descending pain modulation. Biorxiv : the Preprint Server For Biology. PMID 37873091 DOI: 10.1101/2023.10.10.561768  0.322
2022 Malange KF, Navia-Pelaez JM, Dias EV, Lemes JBP, Choi SH, Dos Santos GG, Yaksh TL, Corr M. Macrophages and glial cells: Innate immune drivers of inflammatory arthritic pain perception from peripheral joints to the central nervous system. Frontiers in Pain Research (Lausanne, Switzerland). 3: 1018800. PMID 36387416 DOI: 10.3389/fpain.2022.1018800  0.304
2021 Moreno AM, Alemán F, Catroli GF, Hunt M, Hu M, Dailamy A, Pla A, Woller SA, Palmer N, Parekh U, McDonald D, Roberts AJ, Goodwill V, Dryden I, Hevner RF, ... ... Yaksh TL, et al. Long-lasting analgesia via targeted in situ repression of Na1.7 in mice. Science Translational Medicine. 13. PMID 33692134 DOI: 10.1126/scitranslmed.aay9056  0.725
2020 Gonçalves Dos Santos G, Jimenéz-Andrade JM, Woller SA, Muñoz-Islas E, Ramírez-Rosas MB, Ohashi N, Ferreira Catroli G, Fujita Y, Yaksh TL, Corr M. The neuropathic phenotype of the K/BxN transgenic mouse with spontaneous arthritis: pain, nerve sprouting and joint remodeling. Scientific Reports. 10: 15596. PMID 32973194 DOI: 10.1038/s41598-020-72441-5  0.711
2020 Chernov AV, Hullugundi SK, Eddinger KA, Dolkas J, Remacle AG, Angert M, James BP, Yaksh TL, Strongin AY, Shubayev VI. A myelin basic protein fragment induces sexually dimorphic transcriptome signatures of neuropathic pain in mice. The Journal of Biological Chemistry. PMID 32532796 DOI: 10.1074/jbc.RA120.013696  0.317
2020 Leino T, Yaksh T, Horais K, Haapalinna A. Pharmacodynamics of intrathecal and epidural fadolmidine, an α-adrenoceptor agonist, after bolus and infusion in dogs-comparison with clonidine. Naunyn-Schmiedeberg's Archives of Pharmacology. PMID 32179953 DOI: 10.1007/s00210-020-01850-0  0.343
2019 Gonçalves Dos Santos G, Delay L, Yaksh TL, Corr M. Neuraxial Cytokines in Pain States. Frontiers in Immunology. 10: 3061. PMID 32047493 DOI: 10.3389/fimmu.2019.03061  0.32
2019 Schmelz M, Mantyh P, Malfait AM, Farrar J, Yaksh T, Tive L, Viktrup L. Nerve-growth-factor antibody for the treatment of osteoarthritis pain and chronic low back pain: mechanism of action in the context of efficacy and safety. Pain. PMID 31145219 DOI: 10.1097/J.Pain.0000000000001625  0.38
2018 Zhu W, Tringale KR, Woller SA, You S, Johnson S, Shen H, Schimelman J, Whitney M, Steinauer J, Xu W, Yaksh TL, Nguyen QT, Chen S. Rapid continuous 3D printing of customizable peripheral nerve guidance conduits. Materials Today (Kidlington, England). 21: 951-959. PMID 31156331 DOI: 10.1016/J.Mattod.2018.04.001  0.655
2018 Woller SA, Ocheltree C, Wong SY, Bui A, Fujita Y, Dos Santos GG, Yaksh TL, Corr M. Neuraxial TNF and IFN-beta co-modulate persistent allodynia in arthritic mice. Brain, Behavior, and Immunity. PMID 30465880 DOI: 10.1016/j.bbi.2018.11.014  0.71
2018 Gregus AM, Buczynski MW, Dumlao DS, Norris PC, Rai G, Simeonov A, Maloney DJ, Jadhav A, Xu Q, Wei SC, Fitzsimmons BL, Dennis EA, Yaksh TL. Inhibition of Spinal 15-LOX-1 Attenuates TLR4-Dependent, NSAID-Unresponsive Hyperalgesia in Male Rats. Pain. PMID 30130298 DOI: 10.1097/J.Pain.0000000000001373  0.362
2018 Bruno K, Woller SA, Miller YI, Yaksh TL, Wallace M, Beaton G, Chakravarthy K. Targeting Toll-like Receptor-4 (TLR4) - Emerging Therapeutic Target for Persistent Pain States. Pain. PMID 29889119 DOI: 10.1097/j.pain.0000000000001306  0.717
2018 Woller SA, Choi SH, An EJ, Low H, Schneider DA, Ramachandran R, Kim J, Bae YS, Sviridov D, Corr M, Yaksh TL, Miller YI. Inhibition of Neuroinflammation by AIBP: Spinal Effects upon Facilitated Pain States. Cell Reports. 23: 2667-2677. PMID 29847797 DOI: 10.1016/j.celrep.2018.04.110  0.729
2018 Price TJ, Basbaum AI, Bresnahan J, Chambers JF, De Koninck Y, Edwards RR, Ji RR, Katz J, Kavelaars A, Levine JD, Porter L, Schechter N, Sluka KA, Terman GW, Wager TD, ... Yaksh TL, et al. Transition to chronic pain: opportunities for novel therapeutics. Nature Reviews. Neuroscience. PMID 29765159 DOI: 10.1038/S41583-018-0012-5  0.472
2018 Woller SA, Eddinger KA, Corr M, Yaksh TL. An overview of pathways encoding nociception. Clinical and Experimental Rheumatology. 36: 172. PMID 29461960  0.651
2018 Sorkin LS, Eddinger KA, Woller SA, Yaksh TL. Origins of antidromic activity in sensory afferent fibers and neurogenic inflammation. Seminars in Immunopathology. PMID 29423889 DOI: 10.1007/s00281-017-0669-2  0.74
2018 Woller S, Corr M, Miller Y, Yaksh T. Intrathecal administration of AIBP prevents and reverses pain states The Journal of Pain. 19: S83. DOI: 10.1016/J.Jpain.2017.12.202  0.721
2017 Christianson C, BalkisBas D, Holmdahl R, Selva NK, Yaksh T, Corr M, Firestein G, Svensson CI. Pain mechanisms in animal models of rheumatoid arthritis. Scandinavian Journal of Pain. 1: 168-169. PMID 29913950 DOI: 10.1016/J.Sjpain.2010.05.006  0.583
2017 Woller SA, Eddinger KA, Corr M, Yaksh TL. An overview of pathways encoding nociception. Clinical and Experimental Rheumatology. 35: 40-46. PMID 28967373  0.724
2017 Mamet J, Yeomans DC, Yaksh TL, Manning DC, Harris S. Editor's Highlight: Formulation and Toxicology Evaluation of the Intrathecal AYX1 DNA-Decoy in Sprague Dawley Rats. Toxicological Sciences : An Official Journal of the Society of Toxicology. 159: 76-85. PMID 28903493 DOI: 10.1093/Toxsci/Kfx118  0.344
2017 Rijsdijk M, Agalave NM, van Wijck AJM, Kalkman CJ, Ramachandran R, Baharpoor A, Svensson CI, Yaksh TL. Effect of intrathecal glucocorticoids on the central glucocorticoid receptor in a rat nerve ligation model. Scandinavian Journal of Pain. 16: 1-9. PMID 28850381 DOI: 10.1016/J.Sjpain.2016.12.008  0.593
2017 Mamet J, Harris S, Klukinov M, Yeomans DC, Donahue RR, Taylor BK, Eddinger K, Yaksh T, Manning DC. Pharmacology, pharmacokinetics, and metabolism of the DNA-decoy AYX1 for the prevention of acute and chronic post-surgical pain. Molecular Pain. 13: 1744806917703112. PMID 28394696 DOI: 10.1177/1744806917703112  0.377
2016 Rijsdijk M, Svensson CI, Wijck AJ, Kalkman CJ, Yaksh TL. Analgesic properties of intrathecal glucocorticoids in three well established preclinical pain models. Scandinavian Journal of Pain. 10: 90-102. PMID 28361779 DOI: 10.1016/J.Sjpain.2015.10.006  0.568
2016 Veizi IE, Hayek SM, Hanes M, Galica R, Katta S, Yaksh T. Primary Hydromorphone-Related Intrathecal Catheter Tip Granulomas: Is There a Role for Dose and Concentration? Neuromodulation : Journal of the International Neuromodulation Society. PMID 27505059 DOI: 10.1111/ner.12481  0.326
2016 Sikandar S, Gustavsson Y, Marino MJ, Dickenson AH, Yaksh TL, Sorkin LS, Ramachandran R. Effects of intraplantar Botulinum toxin-B on carrageenan-induced changes in nociception and spinal phosphorylation of GluA1 and Akt. The European Journal of Neuroscience. PMID 27108664 DOI: 10.1111/Ejn.13261  0.61
2016 Woller SA, Ravula SB, Tucci FC, Beaton G, Corr M, Rivkah Isseroff R, Soulika AM, Chigbrow M, Eddinger KA, Yaksh TL. Systemic TAK-242 prevents intrathecal LPS evoked hyperalgesia in male, but not female mice and prevents delayed allodynia following intraplantar formalin in both male and female mice: The role of TLR4 in the evolution of a persistent pain state. Brain, Behavior, and Immunity. PMID 27044335 DOI: 10.1016/j.bbi.2016.03.026  0.72
2016 Podvin S, Yaksh T, Hook V. The Emerging Role of Spinal Dynorphin in Chronic Pain: A Therapeutic Perspective. Annual Review of Pharmacology and Toxicology. 56: 511-33. PMID 26738478 DOI: 10.1146/Annurev-Pharmtox-010715-103042  0.447
2016 Rijsdijk M, Svensson CI, Wijck AJv, Kalkman CJ, Yaksh TL. Analgesic properties of intrathecal glucocorticoids in three well established preclinical pain models Scandinavian Journal of Pain. 10: 90-102. DOI: 10.1016/j.sjpain.2015.10.006  0.549
2016 Woller S, Yaksh T, Corr M. (311) Persistent post-inflammatory mechanical allodynia in male arthritic mice: contribution of TNF and IFNβ The Journal of Pain. 17: S53. DOI: 10.1016/J.Jpain.2016.01.218  0.694
2015 Park HJ, Sandor K, McQueen J, Woller SA, Svensson CI, Corr M, Yaksh TL. The effect of gabapentin and ketorolac on allodynia and conditioned place preference in antibody-induced inflammation. European Journal of Pain (London, England). PMID 26517300 DOI: 10.1002/Ejp.816  0.72
2015 Yaksh TL, Woller SA, Ramachandran R, Sorkin LS. The search for novel analgesics: targets and mechanisms. F1000prime Reports. 7: 56. PMID 26097729 DOI: 10.12703/P7-56  0.756
2015 Woller SA, Corr M, Yaksh TL. Differences in cisplatin-induced mechanical allodynia in male and female mice. European Journal of Pain (London, England). PMID 25716290 DOI: 10.1002/ejp.679  0.69
2015 Bas DB, Abdelmoaty S, Sandor K, Codeluppi S, Fitzsimmons B, Steinauer J, Hua XY, Yaksh TL, Svensson CI. Spinal release of tumour necrosis factor activates c-Jun N-terminal kinase and mediates inflammation-induced hypersensitivity. European Journal of Pain (London, England). 19: 260-70. PMID 24942612 DOI: 10.1002/Ejp.544  0.585
2015 Pleticha J, Maus T, Diehn F, Hettler F, Haupt D, Bongers L, Heilmann L, Kanwar R, Jones B, Kenney B, Royal M, Yaksh T, Iadarola M, Beutler A. (407) A preclinical model of CT fluoroscopy-guided spinal procedures to test DRG-targeted delivery of resiniferatoxin (RTX) The Journal of Pain. 16: S77. DOI: 10.1016/j.jpain.2015.01.326  0.306
2015 Woller S, Ocheltree C, Yaksh T, Corr M. (281) Characterization of Toll-like receptor signaling in pain and arthritis in female mice The Journal of Pain. 16: S46. DOI: 10.1016/J.Jpain.2015.01.199  0.723
2014 Leung A, Shukla S, Li E, Duann JR, Yaksh T. Supraspinal characterization of the thermal grill illusion with fMRI. Molecular Pain. 10: 18. PMID 24612493 DOI: 10.1186/1744-8069-10-18  0.329
2014 Park HJ, Stokes JA, Corr M, Yaksh TL. Toll-like receptor signaling regulates cisplatin-induced mechanical allodynia in mice. Cancer Chemotherapy and Pharmacology. 73: 25-34. PMID 24162377 DOI: 10.1007/S00280-013-2304-9  0.658
2014 Terashima T, Yamaguchi S, Takasusuki T, Hori Y, Yaksh T. Role of spinal β-endorphin on substance P release and c-FOS expression in the spinal cord dorsal horn: 7AP1-3 European Journal of Anaesthesiology. 31: 107. DOI: 10.1097/00003643-201406001-00293  0.381
2014 Woller S, Corr M, Yaksh T. (298) Toll-like receptors in cisplatin-induced neuropathy in male and female mice The Journal of Pain. 15: S50. DOI: 10.1016/J.Jpain.2014.01.208  0.689
2013 Stokes JA, Cheung J, Eddinger K, Corr M, Yaksh TL. Toll-like receptor signaling adapter proteins govern spread of neuropathic pain and recovery following nerve injury in male mice. Journal of Neuroinflammation. 10: 148. PMID 24321498 DOI: 10.1186/1742-2094-10-148  0.7
2013 Kouchek M, Takasusuki T, Terashima T, Yaksh TL, Xu Q. Effects of intrathecal SNC80, a delta receptor ligand, on nociceptive threshold and dorsal horn substance p release. The Journal of Pharmacology and Experimental Therapeutics. 347: 258-64. PMID 23978562 DOI: 10.1124/jpet.113.206573  0.325
2013 Nizet V, Yaksh T. Neuroscience: Bacteria get on your nerves. Nature. 501: 43-4. PMID 23965630 DOI: 10.1038/Nature12550  0.361
2013 Stokes JA, Corr M, Yaksh TL. Spinal toll-like receptor signaling and nociceptive processing: regulatory balance between TIRAP and TRIF cascades mediated by TNF and IFNβ. Pain. 154: 733-42. PMID 23489833 DOI: 10.1016/J.Pain.2013.01.012  0.67
2013 Wahlert A, Funkelstein L, Fitzsimmons B, Yaksh T, Hook V. Spinal astrocytes produce and secrete dynorphin neuropeptides. Neuropeptides. 47: 109-15. PMID 23290538 DOI: 10.1016/J.Npep.2012.10.006  0.441
2013 Park HJ, Stokes JA, Pirie E, Skahen J, Shtaerman Y, Yaksh TL. Persistent hyperalgesia in the cisplatin-treated mouse as defined by threshold measures, the conditioned place preference paradigm, and changes in dorsal root ganglia activated transcription factor 3: the effects of gabapentin, ketorolac, and etanercept. Anesthesia and Analgesia. 116: 224-31. PMID 23223118 DOI: 10.1213/Ane.0B013E31826E1007  0.696
2012 Lampa J, Westman M, Kadetoff D, Agréus AN, Le Maître E, Gillis-Haegerstrand C, Andersson M, Khademi M, Corr M, Christianson CA, Delaney A, Yaksh TL, Kosek E, Svensson CI. Peripheral inflammatory disease associated with centrally activated IL-1 system in humans and mice. Proceedings of the National Academy of Sciences of the United States of America. 109: 12728-33. PMID 22802629 DOI: 10.1073/Pnas.1118748109  0.488
2012 Deer TR, Prager J, Levy R, Rathmell J, Buchser E, Burton A, Caraway D, Cousins M, De Andrés J, Diwan S, Erdek M, Grigsby E, Huntoon M, Jacobs MS, Kim P, ... ... Yaksh T, et al. Polyanalgesic Consensus Conference 2012: recommendations for the management of pain by intrathecal (intraspinal) drug delivery: report of an interdisciplinary expert panel. Neuromodulation : Journal of the International Neuromodulation Society. 15: 436-64; discussion 4. PMID 22748024 DOI: 10.1111/j.1525-1403.2012.00476.x  0.338
2012 Deer TR, Prager J, Levy R, Rathmell J, Buchser E, Burton A, Caraway D, Cousins M, De Andrés J, Diwan S, Erdek M, Grigsby E, Huntoon M, Jacobs MS, Kim P, ... ... Yaksh T, et al. Polyanalgesic Consensus Conference--2012: consensus on diagnosis, detection, and treatment of catheter-tip granulomas (inflammatory masses). Neuromodulation : Journal of the International Neuromodulation Society. 15: 483-95; discussion 4. PMID 22494332 DOI: 10.1111/j.1525-1403.2012.00449.x  0.326
2012 Gregus AM, Doolen S, Dumlao DS, Buczynski MW, Takasusuki T, Fitzsimmons BL, Hua XY, Taylor BK, Dennis EA, Yaksh TL. Spinal 12-lipoxygenase-derived hepoxilin A3 contributes to inflammatory hyperalgesia via activation of TRPV1 and TRPA1 receptors. Proceedings of the National Academy of Sciences of the United States of America. 109: 6721-6. PMID 22493235 DOI: 10.1073/Pnas.1110460109  0.341
2012 Christianson CA, Corr M, Yaksh TL, Svensson CI. K/BxN serum transfer arthritis as a model of inflammatory joint pain. Methods in Molecular Biology (Clifton, N.J.). 851: 249-60. PMID 22351097 DOI: 10.1007/978-1-61779-561-9_19  0.534
2012 Mamet J, Klukinov M, Yaksh T, Malkmus S, Williams S, Taylor B, Donahue R, Porreca F, Xie J, Oyarzo J, Brennan T, Subieta A, Harris S, Schmidt W, Yeomans D. AYX1 DNA-decoy compound prevents the maintenance of pain after incisional, inflammatory or neuropathic injury The Journal of Pain. 13: S71. DOI: 10.1016/J.Jpain.2012.01.297  0.331
2011 Christianson CA, Dumlao DS, Stokes JA, Dennis EA, Svensson CI, Corr M, Yaksh TL. Spinal TLR4 mediates the transition to a persistent mechanical hypersensitivity after the resolution of inflammation in serum-transferred arthritis. Pain. 152: 2881-91. PMID 22019135 DOI: 10.1016/J.Pain.2011.09.020  0.755
2011 Kim HJ, Seol TK, Lee HJ, Yaksh TL, Jun JH. The effect of intrathecal mu, delta, kappa, and alpha-2 agonists on thermal hyperalgesia induced by mild burn on hind paw in rats. Journal of Anesthesia. 25: 884-91. PMID 21983967 DOI: 10.1007/s00540-011-1240-2  0.315
2011 Stokes JA, Corr M, Yaksh TL. Transient tactile allodynia following intrathecal puncture in mouse: contributions of Toll-like receptor signaling. Neuroscience Letters. 504: 215-8. PMID 21964382 DOI: 10.1016/J.Neulet.2011.09.025  0.696
2011 Xu Q, Yaksh TL. A brief comparison of the pathophysiology of inflammatory versus neuropathic pain. Current Opinion in Anaesthesiology. 24: 400-7. PMID 21659872 DOI: 10.1097/ACO.0b013e32834871df  0.31
2011 Xu Q, Fitzsimmons B, Steinauer J, O'Neill A, Newton AC, Hua XY, Yaksh TL. Spinal phosphinositide 3-kinase-Akt-mammalian target of rapamycin signaling cascades in inflammation-induced hyperalgesia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 2113-24. PMID 21307248 DOI: 10.1523/Jneurosci.2139-10.2011  0.305
2010 Christianson CA, Corr M, Firestein GS, Mobargha A, Yaksh TL, Svensson CI. Characterization of the acute and persistent pain state present in K/BxN serum transfer arthritis. Pain. 151: 394-403. PMID 20739123 DOI: 10.1016/J.Pain.2010.07.030  0.583
2010 Saito O, Svensson CI, Buczynski MW, Wegner K, Hua XY, Codeluppi S, Schaloske RH, Deems RA, Dennis EA, Yaksh TL. Spinal glial TLR4-mediated nociception and production of prostaglandin E(2) and TNF. British Journal of Pharmacology. 160: 1754-64. PMID 20649577 DOI: 10.1111/j.1476-5381.2010.00811.x  0.586
2010 Peters CM, Hayashida K, Ewan EE, Nakajima K, Obata H, Xu Q, Yaksh TL, Eisenach JC. Lack of analgesic efficacy of spinal ondansetron on thermal and mechanical hypersensitivity following spinal nerve ligation in the rat. Brain Research. 1352: 83-93. PMID 20637741 DOI: 10.1016/j.brainres.2010.07.020  0.303
2010 Matsui T, Svensson CI, Hirata Y, Mizobata K, Hua XY, Yaksh TL. Release of prostaglandin E(2) and nitric oxide from spinal microglia is dependent on activation of p38 mitogen-activated protein kinase. Anesthesia and Analgesia. 111: 554-60. PMID 20610553 DOI: 10.1213/Ane.0B013E3181E3A2A2  0.569
2010 Buczynski MW, Svensson CI, Dumlao DS, Fitzsimmons BL, Shim JH, Scherbart TJ, Jacobsen FE, Hua XY, Yaksh TL, Dennis EA. Inflammatory hyperalgesia induces essential bioactive lipid production in the spinal cord. Journal of Neurochemistry. 114: 981-93. PMID 20492349 DOI: 10.1111/J.1471-4159.2010.06815.X  0.592
2010 Eisenach JC, Curry R, Tong C, Houle TT, Yaksh TL. Effects of intrathecal ketorolac on human experimental pain. Anesthesiology. 112: 1216-24. PMID 20395821 DOI: 10.1097/Aln.0B013E3181D94D8B  0.372
2010 Eisenach JC, Curry R, Rauck R, Pan P, Yaksh TL. Role of spinal cyclooxygenase in human postoperative and chronic pain. Anesthesiology. 112: 1225-33. PMID 20395820 DOI: 10.1097/ALN.0b013e3181d94dc0  0.304
2010 Fitzsimmons BL, Zattoni M, Svensson CI, Steinauer J, Hua XY, Yaksh TL. Role of spinal p38alpha and beta MAPK in inflammatory hyperalgesia and spinal COX-2 expression. Neuroreport. 21: 313-7. PMID 20134354 DOI: 10.1097/Wnr.0B013E32833774Bf  0.593
2010 Park P, Schachter S, Yaksh T. Intrathecal huperzine A increases thermal escape latency and decreases flinching behavior in the formalin test in rats. Neuroscience Letters. 470: 6-9. PMID 20026382 DOI: 10.1016/j.neulet.2009.12.033  0.326
2010 Christianson CA, Corr M, Firestein GS, Yaksh TL, Svensson CI. Persistent tactile allodynia and spinal glia activation in the K/BxN serum transfer arthritis model Annals of the Rheumatic Diseases. 69: A53-A54. DOI: 10.1136/Ard.2010.129643L  0.552
2009 Sorkin LS, Yaksh TL. Behavioral models of pain states evoked by physical injury to the peripheral nerve. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 6: 609-19. PMID 19789066 DOI: 10.1016/j.nurt.2009.07.007  0.594
2009 Bradesi S, Svensson CI, Steinauer J, Pothoulakis C, Yaksh TL, Mayer EA. Role of spinal microglia in visceral hyperalgesia and NK1R up-regulation in a rat model of chronic stress. Gastroenterology. 136: 1339-48, e1-2. PMID 19249394 DOI: 10.1053/J.Gastro.2008.12.044  0.566
2009 Buczynski M, Dumlao D, Svensson C, Shim J, Fitzsimmons B, Dennis E, Yaksh T, Hua X. Peripheral inflammation-induced spinal eicosanoids: effects of morphine, ketorolac and NDGA The Journal of Pain. 10: S32. DOI: 10.1016/J.Jpain.2009.01.137  0.627
2009 Huang P, Khan I, Yaksh T, Salazar-Grueso E. Intrathecal botulinum toxin B: spinal substance P release and nociception in the mouse formalin pain model The Journal of Pain. 10: S30. DOI: 10.1016/J.JPAIN.2009.01.129  0.433
2008 Nagakura Y, Jones TL, Malkmus SA, Sorkin L, Yaksh TL. The sensitization of a broad spectrum of sensory nerve fibers in a rat model of acute postoperative pain and its response to intrathecal pharmacotherapy. Pain. 139: 569-77. PMID 18692315 DOI: 10.1016/j.pain.2008.06.014  0.531
2008 Crawley B, Saito O, Malkmus S, Fitzsimmons B, Hua XY, Yaksh TL. Acetaminophen prevents hyperalgesia in central pain cascade. Neuroscience Letters. 442: 50-3. PMID 18601979 DOI: 10.1016/j.neulet.2008.06.062  0.349
2008 Svensson CI, Medicherla S, Malkmus S, Jiang Y, Ma JY, Kerr I, Brainin-Mattos J, Powell HC, Luo ZD, Chakravarty S, Dugar S, Higgins LS, Protter AA, Yaksh TL. Role of p38 mitogen activated protein kinase in a model of osteosarcoma-induced pain. Pharmacology, Biochemistry, and Behavior. 90: 664-75. PMID 18584857 DOI: 10.1016/J.Pbb.2008.05.016  0.56
2008 Kim DH, Fitzsimmons B, Hefferan MP, Svensson CI, Wancewicz E, Monia BP, Hung G, Butler M, Marsala M, Hua XY, Yaksh TL. Inhibition of spinal cytosolic phospholipase A(2) expression by an antisense oligonucleotide attenuates tissue injury-induced hyperalgesia. Neuroscience. 154: 1077-87. PMID 18511207 DOI: 10.1016/J.Neuroscience.2008.04.033  0.601
2008 Leung AY, Kim SJ, Schulteis G, Yaksh T. The effect of acupuncture duration on analgesia and peripheral sensory thresholds. Bmc Complementary and Alternative Medicine. 8: 18. PMID 18452622 DOI: 10.1186/1472-6882-8-18  0.392
2008 Bradesi S, Svensson CI, Pothoulakis C, Yaksh TL, Mayer EA. T1450 Glucocorticoids Mediate Spinal Microglia Activation and Visceral Hyperalgesia in a Rat Model of Chronic Stress Gastroenterology. 134: A-558. DOI: 10.1016/S0016-5085(08)62604-9  0.539
2007 Hefferan MP, Kucharova K, Kinjo K, Kakinohana O, Sekerkova G, Nakamura S, Fuchigami T, Tomori Z, Yaksh TL, Kurtz N, Marsala M. Spinal astrocyte glutamate receptor 1 overexpression after ischemic insult facilitates behavioral signs of spasticity and rigidity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 11179-91. PMID 17942713 DOI: 10.1523/JNEUROSCI.0989-07.2007  0.303
2007 Tang Q, Svensson CI, Fitzsimmons B, Webb M, Yaksh TL, Hua XY. Inhibition of spinal constitutive NOS-2 by 1400W attenuates tissue injury and inflammation-induced hyperalgesia and spinal p38 activation. The European Journal of Neuroscience. 25: 2964-72. PMID 17561811 DOI: 10.1111/J.1460-9568.2007.05576.X  0.594
2007 Leung A, Lee E, Fallah A, Schulteis G, Novak E, Duann J, Yaksh T. Effect of Needle Combination on the Analgesic Efficacy of the Tendinomuscular Meridians (TMM) System Medical Acupuncture. 19: 191-200. DOI: 10.1089/ACU.2007.0564  0.375
2006 Svensson CI, Tran TK, Fitzsimmons B, Yaksh TL, Hua XY. Descending serotonergic facilitation of spinal ERK activation and pain behavior. Febs Letters. 580: 6629-34. PMID 17113581 DOI: 10.1016/J.Febslet.2006.11.012  0.584
2006 Svensson CI, Schäfers M, Jones TL, Yaksh TL, Sorkin LS. Covariance among age, spinal p38 MAP kinase activation and allodynia. The Journal of Pain : Official Journal of the American Pain Society. 7: 337-45. PMID 16632323 DOI: 10.1016/J.Jpain.2005.12.007  0.694
2006 Shi TJ, Hua XY, Lu X, Malkmus S, Kinney J, Holmberg K, Wirz S, Ceccatelli S, Yaksh T, Bartfai T, Hökfelt T. Sensory neuronal phenotype in galanin receptor 2 knockout mice: focus on dorsal root ganglion neurone development and pain behaviour. The European Journal of Neuroscience. 23: 627-36. PMID 16487144 DOI: 10.1111/J.1460-9568.2006.04593.X  0.406
2006 Yaksh TL, Kokotos G, Svensson CI, Stephens D, Kokotos CG, Fitzsimmons B, Hadjipavlou-Litina D, Hua XY, Dennis EA. Systemic and intrathecal effects of a novel series of phospholipase A2 inhibitors on hyperalgesia and spinal prostaglandin E2 release. The Journal of Pharmacology and Experimental Therapeutics. 316: 466-75. PMID 16203828 DOI: 10.1124/jpet.105.091686  0.547
2005 Hua XY, Svensson CI, Matsui T, Fitzsimmons B, Yaksh TL, Webb M. Intrathecal minocycline attenuates peripheral inflammation-induced hyperalgesia by inhibiting p38 MAPK in spinal microglia. The European Journal of Neuroscience. 22: 2431-40. PMID 16307586 DOI: 10.1111/J.1460-9568.2005.04451.X  0.593
2005 Svensson CI, Hua XY, Powell HC, Lai J, Porreca F, Yaksh TL. Prostaglandin E2 release evoked by intrathecal dynorphin is dependent on spinal p38 mitogen activated protein kinase. Neuropeptides. 39: 485-94. PMID 16176831 DOI: 10.1016/J.Npep.2005.08.002  0.594
2005 Torchia M, Yaksh T. Unexpected pain in a dog: aberration or worthy of a citation? Agree to disagree. Lab Animal. 34: 19. PMID 16136070 DOI: 10.1038/laban0905-19a  0.352
2005 Leung A, Khadivi B, Duann JR, Cho ZH, Yaksh T. The effect of Ting point (tendinomuscular meridians) electroacupuncture on thermal pain: a model for studying the neuronal mechanism of acupuncture analgesia. Journal of Alternative and Complementary Medicine (New York, N.Y.). 11: 653-61. PMID 16131289 DOI: 10.1089/acm.2005.11.653  0.369
2005 Hua XY, Salgado KF, Gu G, Fitzsimmons B, Kondo I, Bartfai T, Yaksh TL. Mechanisms of antinociception of spinal galanin: how does galanin inhibit spinal sensitization? Neuropeptides. 39: 211-6. PMID 15944014 DOI: 10.1016/j.npep.2004.12.024  0.309
2005 Gu G, Kondo I, Hua XY, Yaksh TL. Resting and evoked spinal substance P release during chronic intrathecal morphine infusion: parallels with tolerance and dependence. The Journal of Pharmacology and Experimental Therapeutics. 314: 1362-9. PMID 15908510 DOI: 10.1124/jpet.105.087718  0.309
2005 Svensson CI, Lucas KK, Hua XY, Powell HC, Dennis EA, Yaksh TL. Spinal phospholipase A2 in inflammatory hyperalgesia: role of the small, secretory phospholipase A2. Neuroscience. 133: 543-53. PMID 15885922 DOI: 10.1016/J.Neuroscience.2005.01.024  0.599
2005 Svensson CI, Fitzsimmons B, Azizi S, Powell HC, Hua XY, Yaksh TL. Spinal p38beta isoform mediates tissue injury-induced hyperalgesia and spinal sensitization. Journal of Neurochemistry. 92: 1508-20. PMID 15748168 DOI: 10.1111/J.1471-4159.2004.02996.X  0.598
2005 Lucas KK, Svensson CI, Hua XY, Yaksh TL, Dennis EA. Spinal phospholipase A2 in inflammatory hyperalgesia: role of group IVA cPLA2. British Journal of Pharmacology. 144: 940-52. PMID 15685208 DOI: 10.1038/Sj.Bjp.0706116  0.57
2005 Yaksh TL, Sorkin LS. Mechanisms of neuropathic pain Current Medicinal Chemistry - Central Nervous System Agents. 5: 129-140. DOI: 10.2174/1568015054022380  0.569
2004 Massie JB, Huang B, Malkmus S, Yaksh TL, Kim CW, Garfin SR, Akeson WH. A preclinical post laminectomy rat model mimics the human post laminectomy syndrome. Journal of Neuroscience Methods. 137: 283-9. PMID 15262072 DOI: 10.1016/j.jneumeth.2004.02.036  0.321
2004 Bartfai T, Lu X, Badie-Mahdavi H, Barr AM, Mazarati A, Hua XY, Yaksh T, Haberhauer G, Ceide SC, Trembleau L, Somogyi L, Kröck L, Rebek J. Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests. Proceedings of the National Academy of Sciences of the United States of America. 101: 10470-5. PMID 15240875 DOI: 10.1073/Pnas.0403802101  0.386
2004 Koetzner L, Gregory JA, Yaksh TL. Intrathecal protease-activated receptor stimulation produces thermal hyperalgesia through spinal cyclooxygenase activity. The Journal of Pharmacology and Experimental Therapeutics. 311: 356-63. PMID 15175421 DOI: 10.1124/Jpet.104.069484  0.305
2004 Ghilardi JR, Svensson CI, Rogers SD, Yaksh TL, Mantyh PW. Constitutive spinal cyclooxygenase-2 participates in the initiation of tissue injury-induced hyperalgesia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 2727-32. PMID 15028765 DOI: 10.1523/Jneurosci.5054-03.2004  0.557
2004 Koetzner L, Hua XY, Lai J, Porreca F, Yaksh T. Nonopioid actions of intrathecal dynorphin evoke spinal excitatory amino acid and prostaglandin E2 release mediated by cyclooxygenase-1 and -2. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 1451-8. PMID 14960618 DOI: 10.1523/JNEUROSCI.1517-03.2004  0.379
2004 Schäfers M, Marziniak M, Sorkin LS, Yaksh TL, Sommer C. Cyclooxygenase inhibition in nerve-injury- and TNF-induced hyperalgesia in the rat. Experimental Neurology. 185: 160-8. PMID 14697327 DOI: 10.1016/j.expneurol.2003.09.015  0.595
2004 Svensson C, Schaefers M, Jones T, Powell H, Yaksh T, Sorkin L. Spinal nociceptive mechanisms The Journal of Pain. 5: S33. DOI: 10.1016/J.Jpain.2004.02.099  0.715
2004 Svensson C, Brainin-Mattos J, Powell H, Luo Z, Yaksh T. Pain pathways The Journal of Pain. 5: S29. DOI: 10.1016/j.jpain.2004.02.081  0.541
2003 Svensson CI, Marsala M, Westerlund A, Calcutt NA, Campana WM, Freshwater JD, Catalano R, Feng Y, Protter AA, Scott B, Yaksh TL. Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing. Journal of Neurochemistry. 86: 1534-44. PMID 12950462 DOI: 10.1046/J.1471-4159.2003.01969.X  0.596
2003 South SM, Kohno T, Kaspar BK, Hegarty D, Vissel B, Drake CT, Ohata M, Jenab S, Sailer AW, Malkmus S, Masuyama T, Horner P, Bogulavsky J, Gage FH, Yaksh TL, et al. A conditional deletion of the NR1 subunit of the NMDA receptor in adult spinal cord dorsal horn reduces NMDA currents and injury-induced pain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 5031-40. PMID 12832526 DOI: 10.1523/Jneurosci.23-12-05031.2003  0.527
2003 Svensson CI, Hua XY, Protter AA, Powell HC, Yaksh TL. Spinal p38 MAP kinase is necessary for NMDA-induced spinal PGE(2) release and thermal hyperalgesia. Neuroreport. 14: 1153-7. PMID 12821799 DOI: 10.1097/00001756-200306110-00010  0.562
2003 Schäfers M, Lee DH, Brors D, Yaksh TL, Sorkin LS. Increased sensitivity of injured and adjacent uninjured rat primary sensory neurons to exogenous tumor necrosis factor-alpha after spinal nerve ligation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 3028-38. PMID 12684490  0.598
2003 Svensson CI, Rew Y, Malkmus S, Schiller PW, Taulane JP, Goodman M, Yaksh TL. Systemic and spinal analgesic activity of a delta-opioid-selective lanthionine enkephalin analog. The Journal of Pharmacology and Experimental Therapeutics. 304: 827-32. PMID 12538839 DOI: 10.1124/Jpet.102.039750  0.502
2002 Eisenach JC, Curry R, Hood DD, Yaksh TL. Phase I safety assessment of intrathecal ketorolac. Pain. 99: 599-604. PMID 12406536 DOI: 10.1016/S0304-3959(02)00208-7  0.346
2002 Rew Y, Malkmus S, Svensson C, Yaksh TL, Chung NN, Schiller PW, Cassel JA, DeHaven RN, Taulane JP, Goodman M. Synthesis and biological activities of cyclic lanthionine enkephalin analogues: delta-opioid receptor selective ligands. Journal of Medicinal Chemistry. 45: 3746-54. PMID 12166947 DOI: 10.1021/Jm020108K  0.469
2002 Svensson CI, Yaksh TL. The spinal phospholipase-cyclooxygenase-prostanoid cascade in nociceptive processing. Annual Review of Pharmacology and Toxicology. 42: 553-83. PMID 11807183 DOI: 10.1146/Annurev.Pharmtox.42.092401.143905  0.595
2001 Sorkin LS, Yaksh TL, Doom CM. Pain models display differential sensitivity to Ca2+-permeable non-NMDA glutamate receptor antagonists. Anesthesiology. 95: 965-73. PMID 11605940  0.61
2001 Yaksh TL, Dirig DM, Conway CM, Svensson C, Luo ZD, Isakson PC. The acute antihyperalgesic action of nonsteroidal, anti-inflammatory drugs and release of spinal prostaglandin E2 is mediated by the inhibition of constitutive spinal cyclooxygenase-2 (COX-2) but not COX-1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 5847-53. PMID 11487607 DOI: 10.1523/Jneurosci.21-16-05847.2001  0.58
2001 Yaksh TL, Ozaki G, McCumber D, Rathbun M, Svensson C, Malkmus S, Yaksh MC. An automated flinch detecting system for use in the formalin nociceptive bioassay. Journal of Applied Physiology (Bethesda, Md. : 1985). 90: 2386-402. PMID 11356806 DOI: 10.1152/Jappl.2001.90.6.2386  0.491
2001 Luo ZD, Chaplan SR, Higuera ES, Sorkin LS, Stauderman KA, Williams ME, Yaksh TL. Upregulation of dorsal root ganglion (alpha)2(delta) calcium channel subunit and its correlation with allodynia in spinal nerve-injured rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 1868-75. PMID 11245671  0.567
2001 Leung A, Wallace MS, Ridgeway B, Yaksh T. Concentration-effect relationship of intravenous alfentanil and ketamine on peripheral neurosensory thresholds, allodynia and hyperalgesia of neuropathic pain. Pain. 91: 177-87. PMID 11240090 DOI: 10.1016/S0304-3959(00)00433-4  0.44
2001 Luo ZD, Chaplan SR, Higuera ES, Sorkin LS, Stauderman KA, Williams ME, Yaksh TL. Upregulation of Dorsal Root Ganglion α2δ Calcium Channel Subunit and Its Correlation with Allodynia in Spinal Nerve-Injured Rats The Journal of Neuroscience. 21: 1868-1875. DOI: 10.1523/JNEUROSCI.21-06-01868.2001  0.548
2000 Bennett G, Deer T, Du Pen S, Rauck R, Yaksh T, Hassenbusch SJ. Future directions in the management of pain by intraspinal drug delivery. Journal of Pain and Symptom Management. 20: S44-50. PMID 10989257 DOI: 10.1016/S0885-3924(00)00201-3  0.322
2000 Wajima Z, Hua XY, Yaksh TL. Inhibition of spinal protein kinase C blocks substance P-mediated hyperalgesia. Brain Research. 877: 314-21. PMID 10986346  0.323
2000 Granados-Soto V, Kalcheva I, Hua X, Newton A, Yaksh TL. Spinal PKC activity and expression: role in tolerance produced by continuous spinal morphine infusion. Pain. 85: 395-404. PMID 10781912 DOI: 10.1016/S0304-3959(99)00281-X  0.556
2000 Yaksh TL. Regulation of spinal nociceptive processing: Where we went when we wandered onto the pain marked by the gate Revista De La Sociedad Espanola Del Dolor. 7: 133-137.  0.33
1999 Sorkin LS, Yaksh TL, Doom CM. Mechanical allodynia in rats is blocked by a Ca2+ permeable AMPA receptor antagonist. Neuroreport. 10: 3523-6. PMID 10619637  0.545
1999 Yaksh TL. Spinal systems and pain processing: development of novel analgesic drugs with mechanistically defined models. Trends in Pharmacological Sciences. 20: 329-37. PMID 10431212 DOI: 10.1016/S0165-6147(99)01370-X  0.328
1999 Yaksh TL, Hua XY, Kalcheva I, Nozaki-Taguchi N, Marsala M. The spinal biology in humans and animals of pain states generated by persistent small afferent input. Proceedings of the National Academy of Sciences of the United States of America. 96: 7680-6. PMID 10393880  0.368
1999 Dirig DM, Yaksh TL. In vitro prostanoid release from spinal cord following peripheral inflammation: effects of substance P, NMDA and capsaicin. British Journal of Pharmacology. 126: 1333-40. PMID 10217526 DOI: 10.1038/sj.bjp.0702427  0.32
1999 Yaksh TL. Spinal pharmacology and the regulation of pain processing Biologia - Section Cellular and Molecular Biology. 54: 11-19.  0.369
1998 Leung A, Wallace M, Ridgeway B, Yaksh T. Neurosensory Findings after Intravenous Alfentanil and Ketamine Infusions in Neuropathic Pain Patients Anesthesiology. 89: 1152A. DOI: 10.1097/00000542-199809190-00081  0.361
1997 Wallace MS, Lee J, Sorkin L, Dunn JS, Yaksh T, Yu A. Intravenous lidocaine: effects on controlling pain after anti-GD2 antibody therapy in children with neuroblastoma--a report of a series. Anesthesia and Analgesia. 85: 794-6. PMID 9322457 DOI: 10.1097/00000539-199710000-00014  0.564
1997 Hua XY, Chen P, Hwang J, Yaksh TL. Antinociception induced by civamide, an orally active capsaicin analogue. Pain. 71: 313-22. PMID 9231875  0.303
1997 Hwang JH, Yaksh TL. The effect of spinal GABA receptor agonists on tactile allodynia in a surgically-induced neuropathic pain model in the rat. Pain. 70: 15-22. PMID 9106805 DOI: 10.1016/S0304-3959(96)03249-6  0.302
1997 Slart R, Yu AL, Yaksh TL, Sorkin LS. An animal model of pain produced by systemic administration of an immunotherapeutic anti-ganglioside antibody. Pain. 69: 119-25. PMID 9060021 DOI: 10.1016/S0304-3959(96)03247-2  0.565
1997 Chaplan SR, Malmberg AB, Yaksh TL. Efficacy of spinal NMDA receptor antagonism in formalin hyperalgesia and nerve injury evoked allodynia in the rat. The Journal of Pharmacology and Experimental Therapeutics. 280: 829-38. PMID 9023297  0.331
1997 Ridgeway B, Wallace M, Gerayli A, Dunn J, Yaksh T. A758 Neurosensory Findings after Intravenous Lidocaine in Patients with Neuropathic Pain Anesthesiology. 87: 758A. DOI: 10.1097/00000542-199709001-00758  0.323
1997 Yaksh TL, Chaplan SR. Physiology and pharmacology of neuropathic pain Anesthesiology Clinics of North America. 15: 335-352. DOI: 10.1016/S0889-8537(05)70337-0  0.302
1996 Jhamandas KH, Marsala M, Ibuki T, Yaksh TL. Spinal amino acid release and precipitated withdrawal in rats chronically infused with spinal morphine. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 2758-66. PMID 8786451 DOI: 10.1523/Jneurosci.16-08-02758.1996  0.368
1996 Yaksh TL. Pharmacology of facilitated nociceptive processing Journal of Musculoskeletal Pain. 4: 201-221. DOI: 10.1300/J094v04n01_12  0.318
1995 Malmberg AB, Yaksh TL. Cyclooxygenase inhibition and the spinal release of prostaglandin E2 and amino acids evoked by paw formalin injection: a microdialysis study in unanesthetized rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 2768-76. PMID 7722627 DOI: 10.1523/Jneurosci.15-04-02768.1995  0.396
1994 Malmberg AB, Yaksh TL. Voltage-sensitive calcium channels in spinal nociceptive processing: Blockade of N- and P-type channels inhibits formalin-induced nociception Journal of Neuroscience. 14: 4882-4890. PMID 8046458 DOI: 10.1523/Jneurosci.14-08-04882.1994  0.312
1994 Marsala M, Sorkin LS, Yaksh TL. Transient spinal ischemia in rat: characterization of spinal cord blood flow, extracellular amino acid release, and concurrent histopathological damage. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 14: 604-14. PMID 8014207 DOI: 10.1038/jcbfm.1994.75  0.58
1994 Isackson J, Wallace M, Ho RJY, Shen D, Yaksh T. Antinociception and Side Effects of L and D Isomer Liposome-encapsulated Alfentanil after Spinal Delivery in Rats Anesthesiology. 81: A915. DOI: 10.1097/00000542-199409001-00914  0.35
1993 Yaksh TL. New horizons in our understanding of the spinal physiology and pharmacology of pain processing Seminars in Oncology. 20: 6-18. PMID 8475414  0.315
1993 Yaksh TL, Malmberg AB. Spinal actions of NSAIDs in blocking spinally mediated hyperalgesia: The role of cyclooxygenase products Agents and Actions. 41: 89-100. PMID 8317344  0.319
1993 Yaksh TL. The spinal pharmacology of facilitation of afferent processing evoked by high-threshold afferent input of the postinjury paint state Current Opinion in Neurology and Neurosurgery. 6: 250-256. PMID 8097639  0.307
1992 Malmberg AB, Yaksh TL. Hyperalgesia mediated by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibition Science. 257: 1276-1279. PMID 1381521 DOI: 10.1126/Science.1381521  0.484
1992 Jensen TS, Yaksh TL. Brainstem excitatory amino acid receptors in nociception: Microinjection mapping and pharmacological characterization of glutamate-sensitive sites in the brainstem associated with algogenic behavior Neuroscience. 46: 535-547. PMID 1347650 DOI: 10.1016/0306-4522(92)90142-O  0.43
1992 Jensen TS, Yaksh TL. The antinociceptive activity of excitatory amino acids in the rat brainstem: an anatomical and pharmacological analysis Brain Research. 569: 255-267. PMID 1347242 DOI: 10.1016/0006-8993(92)90637-O  0.407
1990 Tiseo PJ, Yaksh TL. The spinal pharmacology of urinary function: studies on urinary continence in the unanaesthetized rat Ciba Foundation Symposium. 151: 91-104; discussion 1. PMID 1699710  0.323
1990 Jensen T, Yaksh T. The nociceptive action of excitatory amino acids in the rat brainstem reticular formation Pain. 41: S168. DOI: 10.1016/0304-3959(90)92473-4  0.369
1989 Yaksh TL, Al-Rodhan NR, Jensen TS. Sites of action of opiates in production of analgesia. Progress in Brain Research. 77: 371-94. PMID 2851148 DOI: 10.1016/S0079-6123(08)62803-4  0.346
1989 Jensen TS, Yaksh TL. Comparison of the antinociceptive effect of morphine and glutamate at coincidental sites in the periaqueductal gray and medial medulla in rats Brain Research. 476: 1-9. PMID 2563331 DOI: 10.1016/0006-8993(89)91529-1  0.409
1989 Yaksh TL. Behavioral and autonomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition: effects of modulatory receptor systems and excitatory amino acid antagonists Pain. 37: 111-123. PMID 2542867 DOI: 10.1016/0304-3959(89)90160-7  0.326
1988 Stevens C, Yaksh T. Opioid and adrenergic spinal receptor systems and pain control Nida Research Monograph Series. 343-352. PMID 2841603  0.311
1987 Hashmonai M, Go VL, Yaksh T, Szurszewski JH. Effect of central administration of motilin on migrating complexes in the dog. The American Journal of Physiology. 252: G195-9. PMID 3826347 DOI: 10.1152/AJPGI.1987.252.2.G195  0.315
1987 Howe JR, Yaksh TL, Tyce GM. Intrathecal 6-hydroxydopamine or cervical spinal hemisection reduces norepinephrine content, but not the density of alpha 2-adrenoceptors, in the cat lumbar spinal enlargement. Neuroscience. 21: 377-84. PMID 3039400 DOI: 10.1016/0306-4522(87)90128-X  0.506
1987 Yaksh TL. Spinal opiates: a review of their effect on spinal function with emphasis on pain processing Acta Anaesthesiologica Scandinavica, Supplement. 85: 25-37. PMID 2821725  0.329
1987 Howe JR, Yaksh TL, Go VL. The effect of unilateral dorsal root ganglionectomies or ventral rhizotomies on alpha 2-adrenoceptor binding to, and the substance P, enkephalin, and neurotensin content of, the cat lumbar spinal cord. Neuroscience. 21: 385-94. PMID 2441314 DOI: 10.1016/0306-4522(87)90129-1  0.505
1987 Yaksh TL. Pharmacology and physiology of spinal analgesia Isi Atlas of Science: Pharmacology. 1: 173-176.  0.309
1986 Jensen TS, Yaksh TL. I. Comparison of antinociceptive action of morphine in the periaqueductal gray, medial and paramedial medulla in rat Brain Research. 363: 99-113. PMID 3004644 DOI: 10.1016/0006-8993(86)90662-1  0.493
1986 Jensen TS, Yaksh TL. II. Examination of spinal monoamine receptors through which brainstem opiate-sensitive systems act in the rat Brain Research. 363: 114-127. PMID 3004638 DOI: 10.1016/0006-8993(86)90663-3  0.482
1986 Yaksh TL, Harty GJ, Onofrio BM. High dose of spinal morphine produce a nonopiate receptor-mediated hyperesthesia: clinical and theoretic implications. Anesthesiology. 64: 590-7. PMID 2938524 DOI: 10.1097/00000542-198605000-00008  0.303
1986 Jensen TS, Yaksh TL. III. Comparison of the antinociceptive action of Mu and delta opioid receptor ligands in the periaqueductal gray matter, medial and paramedial ventral medulla in the rat as studied by the microinjection technique Brain Research. 372: 301-312. PMID 2871901 DOI: 10.1016/0006-8993(86)91138-8  0.436
1986 Howe JR, Yaksh TL. Characterization of [3H]rauwolscine binding to alpha 2-adrenoceptor sites in the lumbar spinal cord of the cat: comparison to such binding sites in the cat frontal cerebral cortex. Brain Research. 368: 87-100. PMID 2869820 DOI: 10.1016/0006-8993(86)91045-0  0.473
1986 Micevych PE, Stroink A, Yaksh T, Go VL. Immunochemical studies of substance P and cholecystokinin octapeptide recovery in dorsal horn following unilateral lumbosacral ganglionectomy. Somatosensory Research. 3: 239-60. PMID 2428085 DOI: 10.3109/07367228609144586  0.489
1985 Micevych PE, Yaksh TL, Go VW, Finkelstein JA. Effect of opiates on the release of cholecystokinin from in vitro hypothalamus and frontal cortex of Zucker lean (Fa/-) and obese (fa/fa) rats. Brain Research. 337: 382-5. PMID 3896389 DOI: 10.1016/0006-8993(85)90080-0  0.493
1985 Schmauss C, Shimohigashi Y, Jensen TS, Robbard D, Yaksh TL. Studies on spinal opiate receptor pharmacology. III. Analgetic effects of enkephalin dimers as measured by cutaneous-thermal and visceral-chemical evoked responses Brain Research. 337: 209-215. PMID 2992678 DOI: 10.1016/0006-8993(85)90056-3  0.461
1985 Yaksh TL. Pharmacology of spinal adrenergic systems which modulate spinal nociceptive processing Pharmacology, Biochemistry and Behavior. 22: 845-858. PMID 2861606 DOI: 10.1016/0091-3057(85)90537-4  0.316
1985 Jensen TS, Yaksh TL. Examination of the Antinociceptive Profile Associated with MU and Delta Opioid Receptor Linked Systems in the Brainstem Periaqueductal Gray Matter (PAG) and the Medullary Reticular Formation (MRF) Cephalalgia. 5: 494-495. DOI: 10.1177/03331024850050S3193  0.392
1985 Jensen TS, Yaksh T. Pharmacology The effects of an intrathecal dopamine agonist, apomorphine, on thermal and chemical evoked noxious responses in rats Pain. 23: 309-310. DOI: 10.1016/0304-3959(85)90124-1  0.381
1984 Micevych PE, Go VLW, Yaksh TL. Simultaneous measurement of cholecystokinin- and vasoactive intestinal polypeptide-like immunoreactivity from cat frontal cortex in vitro: Effect of morphine and d-Ala2-d-Leu5-Enkephalin Brain Research. 291: 55-62. PMID 6697185 DOI: 10.1016/0006-8993(84)90650-4  0.498
1984 Jensen TS, Yaksh TL. Effects of an intrathecal dopamine agonist, apomorphine, on thermal and chemical evoked noxious responses in rats Brain Research. 296: 285-293. PMID 6322926 DOI: 10.1016/0006-8993(84)90064-7  0.476
1984 Jhamandas K, Yaksh TL, Harty G, Szolcsanyi J, Go VL. Action of intrathecal capsaicin and its structural analogues on the content and release of spinal substance P: selectivity of action and relationship to analgesia. Brain Research. 306: 215-25. PMID 6205719 DOI: 10.1016/0006-8993(84)90371-8  0.326
1984 Micevych PE, Go VL, Yaksh TL, Finkelstein J. In vitro, release of cholecystokinin from hypothalamus and frontal cortex of Sprague-Dawley, Zucker lean (Fa/-) and obese (fa/fa) rats. Peptides. 5: 73-80. PMID 6200866 DOI: 10.1016/0196-9781(84)90054-8  0.462
1984 Micevych PE, Yaksh TL, Go VL. Studies on the opiate receptor-mediated inhibition of K+-stimulated cholecystokinin and substance P release from cat hypothalamus in vitro. Brain Research. 290: 87-94. PMID 6198038 DOI: 10.1016/0006-8993(84)90738-8  0.509
1984 Jensen TS, Yaksh TL. Spinal monoamine and opiate systems partly mediate the antinociceptive effects produced by glutamate at brainstem sites Brain Research. 321: 287-297. PMID 6149792 DOI: 10.1016/0006-8993(84)90181-1  0.492
1984 Howe JR, Yaksh TL. [3H]p-Aminoclonidine binding to multiple alpha 2-adrenoceptor sites in homogenates of cat frontal cortex and cat spinal cord. European Journal of Pharmacology. 106: 547-59. PMID 6097461 DOI: 10.1016/0014-2999(84)90058-X  0.441
1984 Jensen TS, Yaksh TL. Glutamate-induced analgesia: Effects of intrathecal methysergide, phentolamine and naloxone Pain. 18: S158. DOI: 10.1016/0304-3959(84)90366-X  0.408
1983 Steinman JL, Komisaruk BR, Yaksh TL, Tyce GM. Spinal cord monoamines modulate the antinociceptive effects of vaginal stimulation in rats. Pain. 16: 155-66. PMID 6877846 DOI: 10.1016/0304-3959(83)90205-1  0.306
1983 Schmauss C, Yaksh TL, Shimohigashi Y, Harty G, Jensen T, Rodbard D. Differential association of spinal μ, δ and κ opioid receptors with cutaneous thermal and visceral chemical nociceptive stimuli in the rat Life Sciences. 33: 653-656. PMID 6319919 DOI: 10.1016/0024-3205(83)90587-8  0.473
1983 Yaksh TL. Spinal pharmacology of pain and its modulation Clinical Neurosurgery. 31: 291-303. PMID 6209049  0.336
1983 Micevych PE, Yaksh TL, Szolcsanyi J. Effect of intrathecal capsaicin analogues on the immunofluorescence of peptides and serotonin in the dorsal horn in rats. Neuroscience. 8: 123-31. PMID 6188075 DOI: 10.1016/0306-4522(83)90031-3  0.575
1983 Howe JR, Wang JY, Yaksh TL. Selective antagonism of the antinociceptive effect of intrathecally applied alpha adrenergic agonists by intrathecal prazosin and intrathecal yohimbine. The Journal of Pharmacology and Experimental Therapeutics. 224: 552-8. PMID 6131120  0.469
1982 Tyce GM, Yaksh TL. Monoamine release from cat spinal cord by somatic stimuli: an intrinsic modulatory system. The Journal of Physiology. 314: 513-29. PMID 7310700 DOI: 10.1113/jphysiol.1981.sp013722  0.306
1982 Yaksh TL, Howe JR. Opiate receptors and their definition by antagonists. Anesthesiology. 56: 246-9. PMID 6278990 DOI: 10.1097/00000542-198204000-00002  0.43
1982 Yaksh TL, Schmauss C, Micevych PE, Abay EO, Go VL. Pharmacological studies on the application, disposition, and release of neurotensin in the spinal cord. Annals of the New York Academy of Sciences. 400: 228-43. PMID 6188399  0.56
1982 Micevych PE, Yaksh TL, Go VL. Opiate-mediated inhibition of the release of cholecystokinin and substance P, but not neurotensin from cat hypothalamic slices. Brain Research. 250: 283-9. PMID 6184121 DOI: 10.1016/0006-8993(82)90422-X  0.486
1982 Tung AS, Yaksh TL. In vivo evidence for multiple opiate receptors mediating analgesia in the rat spinal cord Brain Research. 247: 75-83. PMID 6127147 DOI: 10.1016/0006-8993(82)91029-0  0.302
1982 Howe JR, Yaksh TL. Changes in sensitivity to intrathecal norepinephrine and serotonin after 6-hydroxydopamine (6-OHDA), 5,6-dihydroxytryptamine (5,6-DHT) or repeated monoamine administration. The Journal of Pharmacology and Experimental Therapeutics. 220: 311-21. PMID 6120226  0.479
1981 Yaksh TL, Elde RP. Factors governing release of methionine enkephalin-like immunoreactivity from mesencephalon and spinal cord of the cat in vivo. Journal of Neurophysiology. 46: 1056-75. PMID 7299446 DOI: 10.1152/JN.1981.46.5.1056  0.548
1980 Yaksh TL, Elde RP. Release of methionine-enkephalin immunoreactivity from the rat spinal cord in vivo. European Journal of Pharmacology. 63: 359-62. PMID 7389818 DOI: 10.1016/0014-2999(80)90266-6  0.555
1980 Reddy SV, Yaksh TL. Spinal noradrenergic terminal system mediates antinociception. Brain Research. 189: 391-401. PMID 6245762 DOI: 10.1016/0006-8993(80)90099-2  0.324
1980 Wilson PR, Yaksh TL. Pharmacology of pain and analgesia. Anaesthesia and Intensive Care. 8: 248-56. PMID 6158888 DOI: 10.1177/0310057X8000800302  0.326
1980 Howe JR, Yaksh TL. Supersensitivity to the effects of intrathecally injected norepinephrine and serotonin following the intrathecal treatment of 6-hydroxydopamine or 5,6-dihydroxytryptamine in the rat Pharmacologist. 22: 331.  0.446
1979 Yaksh TL, Farb DH, Leeman SE, Jessell TM. Intrathecal capsaicin depletes substance P in the rat spinal cord and produces prolonged thermal analgesia. Science (New York, N.Y.). 206: 481-3. PMID 228392 DOI: 10.1126/Science.228392  0.306
1979 Wall PD, Merrill EG, Yaksh TL. Responses of single units in laminae 2 and 3 of cat spinal cord. Brain Research. 160: 245-60. PMID 216459 DOI: 10.1016/0304-3959(79)90014-9  0.704
1978 Merrill EG, Wall PD, Yaksh TL. Properties of two unmyelinated fibre tracts of the central nervous system: lateral Lissauer tract, and parallel fibres of the cerebellum. The Journal of Physiology. 284: 127-45. PMID 731475 DOI: 10.1113/Jphysiol.1978.Sp012531  0.691
1978 Wall PD, Yaksh TL. Effect of Lissauer tract stimulation on activity in dorsal roots and in ventral roots. Experimental Neurology. 60: 570-83. PMID 680058 DOI: 10.1016/0014-4886(78)90011-0  0.458
1978 Yaksh TL. Opiate receptors for behavioral analgesia resemble those related to the depression of spinal nociceptive neurons Science. 199: 1231-1233. PMID 204008 DOI: 10.1126/Science.204008  0.348
1976 Yaksh TL, Rudy TA. Analgesia mediated by a direct spinal action of narcotics Science. 192: 1357-1358. PMID 1273597  0.343
1975 Pert A, Yaksh T. Localization of the antinociceptive action of morphine in primate brain Pharmacology, Biochemistry and Behavior. 3: 133-138. PMID 1129350 DOI: 10.1016/0091-3057(75)90092-1  0.322
1974 Pert A, Yaksh T. Sites of morphine induced analgesia in the primate brain: relation to pain pathways Brain Research. 80: 135-140. PMID 4424093 DOI: 10.1016/0006-8993(74)90731-8  0.35
Low-probability matches (unlikely to be authored by this person)
2005 Kondo I, Marvizon JC, Song B, Salgado F, Codeluppi S, Hua XY, Yaksh TL. Inhibition by spinal mu- and delta-opioid agonists of afferent-evoked substance P release. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 3651-60. PMID 15814796 DOI: 10.1523/Jneurosci.0252-05.2005  0.3
1995 Yaksh TL, Pogrel JW, Lee YW, Chaplan SR. Reversal of nerve ligation-induced allodynia by spinal alpha-2 adrenoceptor agonists. The Journal of Pharmacology and Experimental Therapeutics. 272: 207-14. PMID 7815335  0.3
2007 Kern SE, Allen J, Wagstaff J, Shafer SL, Yaksh T. The pharmacokinetics of the conopeptide contulakin-G (CGX-1160) after intrathecal administration: an analysis of data from studies in beagles. Anesthesia and Analgesia. 104: 1514-20, table of co. PMID 17513651 DOI: 10.1213/01.ane.0000262038.58546.e6  0.299
2021 Hoshijima H, Hunt M, Nagasaka H, Yaksh T. Systematic Review of Systemic and Neuraxial Effects of Acetaminophen in Preclinical Models of Nociceptive Processing. Journal of Pain Research. 14: 3521-3552. PMID 34795520 DOI: 10.2147/JPR.S308028  0.298
1999 Hua XY, Chen P, Marsala M, Yaksh TL. Intrathecal substance P-induced thermal hyperalgesia and spinal release of prostaglandin E2 and amino acids. Neuroscience. 89: 525-34. PMID 10077333  0.297
1984 Jhamandas K, Yaksh TL, Go VL. Acute and chronic morphine modifies the in vivo release of methionine enkephalin-like immunoreactivity from the cat spinal cord and brain. Brain Research. 297: 91-103. PMID 6722539 DOI: 10.1016/0006-8993(84)90545-6  0.297
1998 Yáñez AM, Peleteiro-Ramos R, Camba MA, Yaksh TL. [Pharmacology of spinal facilitation: the basis for preventive analgesia]. Revista EspañOla De Anestesiología Y ReanimacióN. 45: 17-23. PMID 9580459  0.297
1995 Yaksh TL, Malmberg AB, Ro S, Schiller P, Goodman M. Characterization of the spinal antinociceptive activity of constrained peptidomimetic opioids. The Journal of Pharmacology and Experimental Therapeutics. 275: 63-72. PMID 7562596  0.296
1991 Yamamoto T, Yaksh TL. Spinal pharmacology of thermal hyperesthesia induced by incomplete ligation of sciatic nerve. I. Opioid and nonopioid receptors Anesthesiology. 75: 817-826. PMID 1659256  0.295
1979 Yaksh TL. Direct evidence that spinal serotonin and noradrenaline terminals mediate the spinal antinociceptive effects of morphine in the periaqueductal gray Brain Research. 160: 180-185. PMID 581478 DOI: 10.1016/0006-8993(79)90616-4  0.294
1981 Tung AS, Yaksh TL. Multiple opiate receptors in spinally mediated analgesia Anesthesiology. 55.  0.294
1995 Lee YW, Chaplan SR, Yaksh TL. Systemic and supraspinal, but not spinal, opiates suppress allodynia in a rat neuropathic pain model. Neuroscience Letters. 199: 111-4. PMID 8584236  0.293
1999 Yaksh TL. Regulation of spinal nociceptive processing: where we went when we wandered onto the path marked by the gate. Pain. S149-52. PMID 10491984  0.293
1999 Yoon MH, Yaksh TL. Evaluation of interaction between gabapentin and ibuprofen on the formalin test in rats. Anesthesiology. 91: 1006-13. PMID 10519504  0.293
1987 Stevens CW, Yaksh TL. Chronic antagonist infusion does not increase morphine antinociception in rat spinal cord Brain Research. 425: 388-390. PMID 3427441 DOI: 10.1016/0006-8993(87)90527-0  0.293
1995 Lee YW, Yaksh TL. Analysis of drug interaction between intrathecal clonidine and MK-801 in peripheral neuropathic pain rat model. Anesthesiology. 82: 741-8. PMID 7879942  0.292
2011 Huang PP, Khan I, Suhail MS, Malkmus S, Yaksh TL. Spinal botulinum neurotoxin B: effects on afferent transmitter release and nociceptive processing. Plos One. 6: e19126. PMID 21559464 DOI: 10.1371/journal.pone.0019126  0.292
1994 Naguib M, Yaksh TL. Antinociceptive effects of spinal cholinesterase inhibition and isobolographic analysis of the interaction with μ and α2 receptor systems Anesthesiology. 80: 1338-1348. PMID 8010479  0.291
2003 Kakinohana M, Marsala M, Carter C, Davison JK, Yaksh TL. Neuraxial morphine may trigger transient motor dysfunction after a noninjurious interval of spinal cord ischemia: a clinical and experimental study. Anesthesiology. 98: 862-70. PMID 12657847 DOI: 10.1097/00000542-200304000-00012  0.29
1981 Tung AS, Yaksh TL. Involvement of multiple opiate receptors in spinally mediated analgesia in the rat Pain. 10.  0.29
1996 Dirig DM, Yaksh TL. Thermal hyperalgesia in rat evoked by intrathecal substance P at multiple stimulus intensities reflects an increase in the gain of nociceptive processing. Neuroscience Letters. 220: 93-6. PMID 8981481  0.29
1997 Hwang JH, Yaksh TL. Effect of subarachnoid gabapentin on tactile-evoked allodynia in a surgically induced neuropathic pain model in the rat. Regional Anesthesia. 22: 249-56. PMID 9168217  0.289
1990 Sabbe MB, Yaksh TL. Pharmacology of spinal opioids. Journal of Pain and Symptom Management. 5: 191-203. PMID 2164071 DOI: 10.1016/0885-3924(90)90009-9  0.289
1994 Abram SE, Yaksh TL. Systemic lidocaine blocks nerve injury-induced hyperalgesia and nociceptor-driven spinal sensitization in the rat Anesthesiology. 80: 383-391. PMID 8311320  0.288
2012 Walker SM, Grafe M, Yaksh TL. Intrathecal clonidine in the neonatal rat: dose-dependent analgesia and evaluation of spinal apoptosis and toxicity. Anesthesia and Analgesia. 115: 450-60. PMID 22467896 DOI: 10.1213/Ane.0B013E3182501A09  0.288
1981 Yaksh TL. Spinal opiate analgesia: Characteristics and principles of action Pain. 11. PMID 6276842 DOI: 10.1016/0304-3959(81)90633-3  0.288
1982 Yaksh TL, Abay EO, Go VL. Studies on the location and release of cholecystokinin and vasoactive intestinal peptide in rat and cat spinal cord. Brain Research. 242: 279-90. PMID 6896838 DOI: 10.1016/0006-8993(82)90311-0  0.288
2001 Khan IM, Stanislaus S, Zhang L, Taylor P, Yaksh TL. A-85380 and epibatidine each interact with disparate spinal nicotinic receptor subtypes to achieve analgesia and nociception. The Journal of Pharmacology and Experimental Therapeutics. 297: 230-9. PMID 11259549  0.288
2010 Yaksh TL, Mantyh PW. Spinal delivery of drugs in pain control The Neurobiology of Pain: (Molecular and Cellular Neurobiology). DOI: 10.1093/acprof:oso/9780198515616.003.0008  0.287
2010 Walker SM, Westin BD, Deumens R, Grafe M, Yaksh TL. Effects of intrathecal ketamine in the neonatal rat: evaluation of apoptosis and long-term functional outcome. Anesthesiology. 113: 147-59. PMID 20526188 DOI: 10.1097/Aln.0B013E3181Dcd71C  0.287
2011 Fuchigami T, Kakinohana O, Hefferan MP, Lukacova N, Marsala S, Platoshyn O, Sugahara K, Yaksh TL, Marsala M. Potent suppression of stretch reflex activity after systemic or spinal delivery of tizanidine in rats with spinal ischemia-induced chronic spastic paraplegia. Neuroscience. 194: 160-9. PMID 21871540 DOI: 10.1016/j.neuroscience.2011.08.022  0.286
2017 Wang Z, Wu C, Mascarenhas N, Yaksh T, Di_Nardo A. 372 Anabotulinum toxin reduces LL-37 induced rosacea inflammation by blocking mast cell degranulation Journal of Investigative Dermatology. 137: S256. DOI: 10.1016/j.jid.2017.07.567  0.286
2021 Navia-Pelaez JM, Choi SH, Dos Santos Aggum Capettini L, Xia Y, Gonen A, Agatisa-Boyle C, Delay L, Gonçalves Dos Santos G, Catroli GF, Kim J, Lu JW, Saylor B, Winkels H, Durant CP, Ghosheh Y, ... ... Yaksh TL, et al. Normalization of cholesterol metabolism in spinal microglia alleviates neuropathic pain. The Journal of Experimental Medicine. 218. PMID 33970188 DOI: 10.1084/jem.20202059  0.286
1987 Yaksh T. Neurochemical mediators of analgesia in the spinal cord Pain. 30: S224. DOI: 10.1016/0304-3959(87)91512-0  0.285
2014 Ramachandran R, Yaksh TL. Therapeutic use of botulinum toxin in migraine: mechanisms of action. British Journal of Pharmacology. 171: 4177-92. PMID 24819339 DOI: 10.1111/bph.12763  0.285
1990 Aimone L, Yaksh T. Release of norepinephrine from rat dorsal spinal cord slices: Modulation by opioids Pain. 41: S173. DOI: 10.1016/0304-3959(90)92482-6  0.284
1994 Wallace MS, Yanez AM, Ho RJY, Shen DD, Yaksh TL. Antinociception and side effects of liposome-encapsulated alfentanil after spinal delivery in rats Anesthesia and Analgesia. 79: 778-786. PMID 7943792  0.284
1987 Stevens CW, Weinger MB, Yaksh TL. Intrathecal dynorphins suppress hindlimb electromyographic activity in rats European Journal of Pharmacology. 138: 299-302. PMID 2887441 DOI: 10.1016/0014-2999(87)90449-3  0.283
1985 Yaksh TL, Noueihed R. The physiology and pharmacology of spinal opiates. Annual Review of Pharmacology and Toxicology. 25: 433-62. PMID 2988422 DOI: 10.1146/ANNUREV.PA.25.040185.002245  0.283
2002 Cizkova D, Marsala J, Lukacova N, Marsala M, Jergova S, Orendacova J, Yaksh TL. Localization of N-type Ca2+ channels in the rat spinal cord following chronic constrictive nerve injury. Experimental Brain Research. 147: 456-63. PMID 12444477 DOI: 10.1007/s00221-002-1217-3  0.282
1994 Abram SE, Marsala M, Yaksh TL. Analgesic and neurotoxic effects of intrathecal corticosteroids in rats. Anesthesiology. 81: 1198-205. PMID 7978478 DOI: 10.1097/00000542-199411000-00013  0.282
2001 Mantyh PW, Yaksh TL. Sensory neurons are PARtial to pain. Nature Medicine. 7: 772-3. PMID 11433334 DOI: 10.1038/89880  0.282
1994 Calcutt NA, Malmberg AB, Yamamoto T, Yaksh TL. Tolrestat treatment prevents modification of the formalin test model of prolonged pain in hyperglycemic rats. Pain. 58: 413-20. PMID 7838591 DOI: 10.1016/0304-3959(94)90136-8  0.282
1998 Buerkle H, Marsala M, Yaksh TL. Effect of continuous spinal remifentanil infusion on behaviour and spinal glutamate release evoked by subcutaneous formalin in the rat. British Journal of Anaesthesia. 80: 348-53. PMID 9623437  0.281
2014 Mamet J, Klukinov M, Yaksh TL, Malkmus SA, Williams S, Harris S, Manning DC, Taylor BK, Donahue RR, Porreca F, Xie JY, Oyarzo J, Brennan TJ, Subieta A, Schmidt WK, et al. Single intrathecal administration of the transcription factor decoy AYX1 prevents acute and chronic pain after incisional, inflammatory, or neuropathic injury. Pain. 155: 322-33. PMID 24145208 DOI: 10.1016/J.Pain.2013.10.015  0.28
1995 Marsala M, Malmberg AB, Yaksh TL. The spinal loop dialysis catheter: characterization of use in the unanesthetized rat. Journal of Neuroscience Methods. 62: 43-53. PMID 8750084  0.28
2000 Bennett G, Serafini M, Burchiel K, Buchser E, Classen A, Deer T, Du Pen S, Ferrante FM, Hassenbusch SJ, Lou L, Maeyaert J, Penn R, Portenoy RK, Rauck R, Willis KD, ... Yaksh T, et al. Evidence-based review of the literature on intrathecal delivery of pain medication. Journal of Pain and Symptom Management. 20: S12-36. PMID 10989255 DOI: 10.1016/S0885-3924(00)00204-9  0.28
2014 Rijsdijk M, van Wijck AJ, Kalkman CJ, Yaksh TL. The effects of glucocorticoids on neuropathic pain: a review with emphasis on intrathecal methylprednisolone acetate delivery. Anesthesia and Analgesia. 118: 1097-112. PMID 24781577 DOI: 10.1213/ANE.0000000000000161  0.28
1995 Yanez AM, Wallace M, Ho R, Shen D, Yaksh TL. Touch-evoked agitation produced by spinally administered phospholipid emulsion and liposomes in rats. Structure-activity relation. Anesthesiology. 82: 1189-98. PMID 7741294 DOI: 10.1097/00000542-199505000-00014  0.279
2021 Walker SM, Malkmus S, Eddinger K, Steinauer J, Roberts AJ, Shubayev VI, Grafe MR, Powell SB, Yaksh TL. Evaluation of Neurotoxicity and Long-Term Function and Behavior following Intrathecal 1% 2-Chloroprocaine in Juvenile Rats. Neurotoxicology. PMID 34801587 DOI: 10.1016/j.neuro.2021.11.010  0.279
2004 Hua XY, Hayes CS, Hofer A, Fitzsimmons B, Kilk K, Langel U, Bartfai T, Yaksh TL. Galanin acts at GalR1 receptors in spinal antinociception: synergy with morphine and AP-5. The Journal of Pharmacology and Experimental Therapeutics. 308: 574-82. PMID 14610237 DOI: 10.1124/jpet.103.058289  0.278
2014 Marino MJ, Terashima T, Steinauer JJ, Eddinger KA, Yaksh TL, Xu Q. Botulinum toxin B in the sensory afferent: transmitter release, spinal activation, and pain behavior. Pain. 155: 674-84. PMID 24333775 DOI: 10.1016/j.pain.2013.12.009  0.278
1977 Yaksh TL, Huang SP, Rudy TA. The direct and specific opiate-like effect of met5-enkephalin and analogues on the spinal cord. Neuroscience. 2: 593-6. PMID 917285 DOI: 10.1016/0306-4522(77)90055-0  0.278
1979 Yaksh TL, Tyce GM. Microinjection of morphine into the periaqueductal gray evokes the release of serotonin from spinal cord. Brain Research. 171: 176-81. PMID 466437 DOI: 10.1016/0006-8993(79)90747-9  0.277
1977 Rudy TA, Yaksh TL. Hyperthermic effects of morphine in the rat spinal cord [proceedings] Journal of Physiology. 268. PMID 874880  0.277
2015 Pellett S, Yaksh TL, Ramachandran R. Current Status and Future Directions of Botulinum Neurotoxins for Targeting Pain Processing. Toxins. 7: 4519-63. PMID 26556371 DOI: 10.3390/toxins7114519  0.277
1992 Stoddard SL, Tyce GM, Cook JA, Gaumann DM, Yaksh TL. Adrenal medullary secretion with splanchnic stimulation in spinal cats. Journal of the Autonomic Nervous System. 38: 105-16. PMID 1619210 DOI: 10.1016/0165-1838(92)90231-5  0.277
1982 Taylor JE, Yaksh TL, Richelson E. Agonist regulation of muscarinic acetylcholine receptors in rat spinal cord. Journal of Neurochemistry. 39: 521-4. PMID 7086433 DOI: 10.1111/j.1471-4159.1982.tb03975.x  0.277
1976 Yaksh TL, Rudy TA. Chronic catheterization of the spinal subarachnoid space Physiology and Behavior. 17: 1031-1036. PMID 14677603 DOI: 10.1016/0031-9384(76)90029-9  0.276
1997 Dirig DM, Konin GP, Isakson PC, Yaksh TL. Effect of spinal cyclooxygenase inhibitors in rat using the formalin test and in vitro prostaglandin E2 release. European Journal of Pharmacology. 331: 155-60. PMID 9274974  0.276
1982 Tung AS, Yaksh TL. The antinociceptive effects of epidural opiates in the cat: Studies on the pharmacology and the effects of lipophilicity in spinal analgesia Pain. 12: 343-356. PMID 7099701 DOI: 10.1016/0304-3959(82)90179-8  0.275
2008 Nazarian A, Gu G, Gracias NG, Wilkinson K, Hua XY, Vasko MR, Yaksh TL. Spinal N-methyl-D-aspartate receptors and nociception-evoked release of primary afferent substance P. Neuroscience. 152: 119-27. PMID 18222611 DOI: 10.1016/j.neuroscience.2007.11.037  0.275
1978 Yaksh TL, Frederickson RC, Huang SP, Rudy TA. In vivo comparison of the receptor populations acted upon in the spinal cord by morphine and pentapeptides in the production of analgesia. Brain Research. 148: 516-20. PMID 207391 DOI: 10.1016/0006-8993(78)90740-0  0.273
2005 Nielsen CK, Lewis RJ, Alewood D, Drinkwater R, Palant E, Patterson M, Yaksh TL, McCumber D, Smith MT. Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain. Pain. 118: 112-24. PMID 16154696 DOI: 10.1016/J.Pain.2005.08.002  0.273
2013 Svensson E, Persson J, Fitzsimmons B, Yaksh TL. Intrathecal neurosteroids and a neurosteroid antagonist: effects on inflammation-evoked thermal hyperalgesia and tactile allodynia. Neuroscience Letters. 548: 27-32. PMID 23707652 DOI: 10.1016/j.neulet.2013.05.027  0.273
2012 Suhail MS, Christianson C, Koehrn F, Malkmus SA, Mitchell W, Corr M, Yaksh TL. Effects of long term polyarthritis and subsequent NSAID treatment on activity with disassociation of tactile allodynia in the mouse. Neurocomputing. 84: 47-52. PMID 22547902 DOI: 10.1016/J.Neucom.2011.12.020  0.272
2013 Hamurtekin E, Fitzsimmons BL, Shubayev VI, Grafe MR, Deumens R, Yaksh TL, Walker SM. Evaluation of spinal toxicity and long-term spinal reflex function after intrathecal levobupivaciane in the neonatal rat. Anesthesiology. 119: 142-55. PMID 23514721 DOI: 10.1097/ALN.0b013e31828fc7e7  0.272
1990 Sosnowski M, Yaksh TL. Spinal administration of receptor-selective drugs as analgesics: New horizons Journal of Pain and Symptom Management. 5: 204-213. PMID 2164072 DOI: 10.1016/0885-3924(90)90010-H  0.272
2012 Deer TR, Levy R, Prager J, Buchser E, Burton A, Caraway D, Cousins M, De Andrés J, Diwan S, Erdek M, Grigsby E, Huntoon M, Jacobs MS, Kim P, Kumar K, ... ... Yaksh T, et al. Polyanalgesic Consensus Conference--2012: recommendations to reduce morbidity and mortality in intrathecal drug delivery in the treatment of chronic pain. Neuromodulation : Journal of the International Neuromodulation Society. 15: 467-82; discussion 4. PMID 22849581 DOI: 10.1111/j.1525-1403.2012.00486.x  0.271
2005 Butler M, Hayes CS, Chappell A, Murray SF, Yaksh TL, Hua XY. Spinal distribution and metabolism of 2'-O-(2-methoxyethyl)-modified oligonucleotides after intrathecal administration in rats. Neuroscience. 131: 705-15. PMID 15730875 DOI: 10.1016/j.neuroscience.2004.11.038  0.271
2011 Yaksh TL. Spinal toxins can have persistent adverse effects. Pain Medicine (Malden, Mass.). 12: 991-2. PMID 21752177 DOI: 10.1111/j.1526-4637.2011.01164.x  0.271
1999 Hua XY, Chen P, Yaksh TL. Inhibition of spinal protein kinase C reduces nerve injury-induced tactile allodynia in neuropathic rats. Neuroscience Letters. 276: 99-102. PMID 10624801  0.271
1977 Yaksh TL, Kohl RL, Rudy TA. Induction of tolerance and withdrawal in rats receiving morphine in the spinal subarachnoid space. European Journal of Pharmacology. 42: 275-84. PMID 15848 DOI: 10.1016/0014-2999(77)90294-1  0.271
2013 Terashima T, Xu Q, Yamaguchi S, Yaksh TL. Intrathecal P/Q- and R-type calcium channel blockade of spinal substance P release and c-Fos expression. Neuropharmacology. 75: 1-8. PMID 23810829 DOI: 10.1016/j.neuropharm.2013.06.018  0.271
2010 Westin BD, Walker SM, Deumens R, Grafe M, Yaksh TL. Validation of a preclinical spinal safety model: effects of intrathecal morphine in the neonatal rat. Anesthesiology. 113: 183-99. PMID 20526189 DOI: 10.1097/Aln.0B013E3181Dcd6Ec  0.27
1987 Stevens CW, Pezalla PD, Yaksh TL. Spinal antinociceptive action of three representative opioid peptides in frogs. Brain Research. 402: 201-3. PMID 2881600 DOI: 10.1016/0006-8993(87)91069-9  0.27
1991 Gaumann DM, Grabow TS, Yaksh TL, Casey SJ, Rodriguez M. Intrathecal somatostatin, somatostatin analogs, substance P analog and dynorphin A cause comparable neurotoxicity in rats. Neuroscience. 39: 761-74. PMID 1711172 DOI: 10.1016/0306-4522(90)90259-7  0.27
1981 Yaksh TL, Tyce GM. Release of norepinephrine and serotonin in cat spinal cord: Direct in vivo evidence for the activation of descending monoamine pathways by somatic stimulation Journal De Physiologie. 77: 483-487. PMID 7288659  0.27
1989 Sosnowski M, Yaksh TL. SYMMETRIC TOLERANCE AFTER CONTINUOUS SPINAL INFUSION OF MU AGONISTS IN RATS Anesthesiology. 71: A621. DOI: 10.1097/00000542-198909001-00621  0.27
1986 Yaksh TL, Dirksen R, Harty GJ. Antinociceptive effects of intrathecally injected cholinomimetic drugs in the rat and cat. European Journal of Pharmacology. 117: 81-8. PMID 3841316 DOI: 10.1016/0014-2999(85)90474-1  0.269
1997 Yang LC, Marsala M, Orendacova J, Yaksh TL. Knee joint inflammation attenuates spinal FOS expression after unilateral paw formalin injection in rat. Neuroscience Letters. 225: 89-92. PMID 9147381  0.269
1997 Dunbar SA, Yaksh TL. Spinal infusion of N-methyl-D-aspartate antagonist MK801 induces hypersensitivity to the spinal alpha-2 agonist ST91 in the rat. The Journal of Pharmacology and Experimental Therapeutics. 281: 1219-25. PMID 9190856  0.269
2011 Takasusuki T, Yaksh TL. The effects of intrathecal and systemic gabapentin on spinal substance P release. Anesthesia and Analgesia. 112: 971-6. PMID 21385982 DOI: 10.1213/ANE.0b013e31820f2a16  0.269
1990 Yanez A, Sabbe MB, Stevens CW, Yaksh TL. Interaction of midazolam and morphine in the spinal cord of the rat. Neuropharmacology. 29: 359-64. PMID 2160622 DOI: 10.1016/0028-3908(90)90094-8  0.269
2004 Malkmus SA, Yaksh TL. Intrathecal catheterization and drug delivery in the rat. Methods in Molecular Medicine. 99: 109-21. PMID 15131333 DOI: 10.1385/1-59259-770-X:109  0.269
2016 Yaksh TL, Fisher C, Hockman T, Wiese A. Current and Future Issues in the development of spinal agents for the management of pain. Current Neuropharmacology. PMID 26861470  0.268
1992 Aquino RB, Brown MR, Rivier JR, Yaksh TL. CHARACTERIZATION OF SPINAL RECEPTOR ACTED UPON BY NEUROPEPTIDE Y (NPY) TO PRODUCE ANTINOCICEPTION Anesthesiology. 77: A809. DOI: 10.1097/00000542-199209001-00809  0.268
1990 Sosnowski M, Yaksh TL. The role of spinal and brainstem adenosine receptors in the modulation of the volume-evoked micturition reflex in the unanesthetized rat Brain Research. 515: 207-213. PMID 2357559 DOI: 10.1016/0006-8993(90)90597-5  0.268
1997 Yaksh TL. Pharmacology and mechanisms of opioid analgesic activity. Acta Anaesthesiologica Scandinavica. 41: 94-111. PMID 9061092  0.268
2000 Bennett G, Burchiel K, Buchser E, Classen A, Deer T, Du Pen S, Ferrante FM, Hassenbusch SJ, Lou L, Maeyaert J, Penn R, Portenoy RK, Rauck R, Serafini M, Willis KD, ... Yaksh T, et al. Clinical guidelines for intraspinal infusion: report of an expert panel. PolyAnalgesic Consensus Conference 2000. Journal of Pain and Symptom Management. 20: S37-43. PMID 10989256 DOI: 10.1016/S0885-3924(00)00202-5  0.268
1986 Stevens CW, Yaksh TL. Spinal action of dermorphin, an extremely potent opioid peptide from frog skin Brain Research. 385: 300-304. PMID 2877713 DOI: 10.1016/0006-8993(86)91076-0  0.268
1996 Dunbar S, Yaksh TL. Concurrent spinal infusion of MK801 blocks spinal tolerance and dependence induced by chronic intrathecal morphine in the rat. Anesthesiology. 84: 1177-88. PMID 8624012 DOI: 10.1097/00000542-199605000-00020  0.267
1996 Ishikawa T, Yaksh TL. [Concurrent characterization of spinal amino acid release and touch-evoked allodynia produced by spinal glycine or GABAA receptor antagonists]. Masui. the Japanese Journal of Anesthesiology. 45: 439-44. PMID 8725598  0.267
2003 Ibuki T, Marsala M, Masuyama T, Yaksh TL. Spinal amino acid release and repeated withdrawal in spinal morphine tolerant rats. British Journal of Pharmacology. 138: 689-97. PMID 12598423 DOI: 10.1038/sj.bjp.0705102  0.267
2003 Hayes CS, Mulkmus SA, Cizkova D, Yaksh TL, Hua XY. A double-lumen intrathecal catheter for studies of modulation of spinal opiate tolerance. Journal of Neuroscience Methods. 126: 165-73. PMID 12814841 DOI: 10.1016/S0165-0270(03)00078-5  0.267
1995 Isackson J, Wallace MS, Ho RJ, Shen DD, Yaksh TL. Antinociception and side effects of L- and D-dipalmitoylphosphatidyl choline liposome-encapsulated alfentanil after spinal delivery in rats. Pharmacology & Toxicology. 77: 333-40. PMID 8778746  0.267
1998 Hua XY, Chen P, Polgar E, Nagy I, Marsala M, Phillips E, Wollaston L, Urban L, Yaksh TL, Webb M. Spinal neurokinin NK1 receptor down-regulation and antinociception: effects of spinal NK1 receptor antisense oligonucleotides and NK1 receptor occupancy. Journal of Neurochemistry. 70: 688-98. PMID 9453563 DOI: 10.1046/J.1471-4159.1998.70020688.X  0.266
1997 Zhang Y, Malmberg AB, Yaksh TL, Sjölund B, Sundler F, Håkanson R. Capsaicin-evoked release of pituitary adenylate cyclase activating peptide (PACAP) and calcitonin gene-related peptide (CGRP) from rat spinal cord in vivo. Regulatory Peptides. 69: 83-7. PMID 9178350  0.266
2021 Gregus AM, Levine IS, Eddinger KA, Yaksh TL, Buczynski MW. Sex differences in neuroimmune and glial mechanisms of pain. Pain. 162: 2186-2200. PMID 34256379 DOI: 10.1097/j.pain.0000000000002215  0.265
2019 Eisenach JC, Yaksh TL. Spinal Exparel®-an extended duration of preclinical study needed. British Journal of Anaesthesia. 122: 298-300. PMID 30770045 DOI: 10.1016/j.bja.2018.11.021  0.265
1995 Ishikawa T, Marsala M, Yaksh TL. SCIATIC NERVE STIMULATION EVOKES A MARKED RELEASE OF EXCITATORY AMINO ACIDS IN CSF DURING SUBINJURIOUS SPINAL CORD ISCHEMIA IN RAT Shock. 4: 33. DOI: 10.1097/00024382-199512001-00122  0.264
1996 Yang LC, Marsala M, Yaksh TL. Characterization of time course of spinal amino acids, citrulline and PGE2 release after carrageenan/kaolin-induced knee joint inflammation: a chronic microdialysis study. Pain. 67: 345-54. PMID 8951928  0.264
1995 Malmberg AB, Yaksh TL. The effect of morphine on formalin-evoked behaviour and spinal release of excitatory amino acids and prostaglandin E2 using microdialysis in conscious rats. British Journal of Pharmacology. 114: 1069-75. PMID 7780642  0.263
1996 Takano Y, Takano M, Sato I, Yaksh TL. Effects of spinal naloxone and naltrindole on the antinociceptive action of intrathecally administered dexmedetomidine. Journal of Anesthesia. 10: 194-8. PMID 23839625 DOI: 10.1007/BF02471390  0.263
1980 Yaksh TL, Jessell TM, Gamse R, Mudge AW, Leeman SE. Intrathecal morphine inhibits substance P release from mammalian spinal cord in vivo. Nature. 286: 155-7. PMID 6157098 DOI: 10.1038/286155A0  0.263
1994 Malmberg AB, Rafferty MF, Yaksh TL. Antinociceptive effect of spinally delivered prostaglandin E receptor antagonists in the formalin test on the rat. Neuroscience Letters. 173: 193-6. PMID 7936413 DOI: 10.1016/0304-3940(94)90181-3  0.263
1993 al-Rodhan NR, Yaksh TL, Kelly PJ. Comparison of the neurochemistry of the endogenous opioid systems in two brainstem pain-processing centers. Stereotactic and Functional Neurosurgery. 59: 15-9. PMID 1295034 DOI: 10.1159/000098910  0.262
1989 Sosnowski M, Yaksh TL. Role of Spinal Adenosine Receptors in Modulating the Hyperesthesia Produced by Spinal Glycine Receptor Antagonism Anesthesia & Analgesia. 69: 587???592. DOI: 10.1213/00000539-198911000-00006  0.262
1983 Yaksh TL. In vivo studies on spinal opiate receptor systems mediating antinociception. I. Mu and delta receptor profiles in the primate Journal of Pharmacology and Experimental Therapeutics. 226: 303-316. PMID 6308205  0.262
1990 Roddy DR, Yaksh TL, Aimone LD, Go VL. Distribution of neuropeptide Y in the spinal cords of cat, dog, rat, man and pig. Regulatory Peptides. 29: 81-92. PMID 2217906 DOI: 10.1016/0167-0115(90)90071-4  0.262
1988 Sabbe M, Mjanger E, Sosnowski M, Yaksh T. Study on Tolerance Development after Daily Epidural Injection of Sufentanil in Dogs Anesthesiology. 69: A392-A392. DOI: 10.1097/00000542-198809010-00391  0.262
1995 Chaplan SR, Bach FW, Shafer SL, Yaksh TL. Prolonged alleviation of tactile allodynia by intravenous lidocaine in neuropathic rats. Anesthesiology. 83: 775-85. PMID 7574057 DOI: 10.1097/00000542-199510000-00017  0.261
2013 Gregus AM, Dumlao DS, Wei SC, Norris PC, Catella LC, Meyerstein FG, Buczynski MW, Steinauer JJ, Fitzsimmons BL, Yaksh TL, Dennis EA. Systematic analysis of rat 12/15-lipoxygenase enzymes reveals critical role for spinal eLOX3 hepoxilin synthase activity in inflammatory hyperalgesia. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 1939-49. PMID 23382512 DOI: 10.1096/Fj.12-217414  0.261
1984 Nyberg F, Yaksh TL, Terenius L. Opioid activity released from cat spinal cord by sciatic nerve stimulation. Life Sciences. 17-20. PMID 6664216 DOI: 10.1016/0024-3205(83)90433-2  0.26
2016 Ko JS, Eddinger KA, Angert M, Chernov AV, Dolkas J, Strongin AY, Yaksh TL, Shubayev VI. Spinal activity of interleukin 6 mediates myelin basic protein-induced allodynia. Brain, Behavior, and Immunity. PMID 26970355 DOI: 10.1016/j.bbi.2016.03.003  0.259
2018 Shubayev V, Strongin A, Yaksh T. [EXPRESS] Structural homology of myelin basic protein and muscarinic acetylcholine receptor: Significance in the pathogenesis of complex regional pain syndrome. Molecular Pain. 1744806918815005. PMID 30392459 DOI: 10.1177/1744806918815005  0.259
1981 Yaksh TL, Harty GJ. Simple method for rapid removal of rat spinal cord Brain Research Bulletin. 6: 449-450. PMID 7248810 DOI: 10.1016/S0361-9230(81)80016-0  0.258
2010 Oshiro M, Hefferan MP, Kakinohana O, Lukacova N, Sugahara K, Yaksh TL, Marsala M. Suppression of stretch reflex activity after spinal or systemic treatment with AMPA receptor antagonist NGX424 in rats with developed baclofen tolerance. British Journal of Pharmacology. 161: 976-85. PMID 20977450 DOI: 10.1111/j.1476-5381.2010.00954.x  0.258
2003 Yaksh TL. Preclinical work leading to the development of spinal analgesia. Anesthesiology. 99: 224-5. PMID 12826864 DOI: 10.1097/00000542-200307000-00034  0.258
1990 Yaksh TL, Gauman DM. Spinal Somatostatin Studies in Animals Anesthesia & Analgesia. 70: 227???229. DOI: 10.1213/00000539-199002000-00026  0.258
1984 Schmauss C, Yaksh TL. In vivo studies on spinal opiate receptor systems mediating antinociception. II. Pharmacological profiles suggesting a differential association of mu, delta, and kappa receptors with visceral chemical and cutaneous thermal stimuli in the rat Journal of Pharmacology and Experimental Therapeutics. 228: 1-12. PMID 6319664  0.258
2000 Yaksh TL. Spinal tolerance and dependence: Some observations on the role of spinal N-methyl-D-aspartate receptors and phosphorylation in the loss of opioid analgesic responses Pain Research and Management. 5: 33-39.  0.258
1996 Dunbar S, Yaksh TL. Effect of spinal infusion of L-NAME, a nitric oxide synthase inhibitor, on spinal tolerance and dependence induced by chronic intrathecal morphine in the rat. Neuroscience Letters. 207: 33-6. PMID 8710203 DOI: 10.1016/0304-3940(96)12481-2  0.258
2000 Yang LC, Orendacova J, Wang V, Ishikawa T, Yaksh TL, Marsala M. Transient spinal cord ischemia in rat: the time course of spinal FOS protein expression and the effect of intraischemic hypothermia (27 degrees C). Cellular and Molecular Neurobiology. 20: 351-65. PMID 10789833  0.258
2004 Allen JW, Yaksh TL. Tissue injury models of persistent nociception in rats. Methods in Molecular Medicine. 99: 25-34. PMID 15131326 DOI: 10.1385/1-59259-770-X:025  0.257
1994 Marsala M, Vanicky I, Yaksh TL. Effect of graded hypothermia (27 degrees to 34 degrees C) on behavioral function, histopathology, and spinal blood flow after spinal ischemia in rat. Stroke. 25: 2038-46. PMID 8091450 DOI: 10.1161/01.STR.25.10.2038  0.257
2012 Walker SM, Yaksh TL. Neuraxial analgesia in neonates and infants: a review of clinical and preclinical strategies for the development of safety and efficacy data. Anesthesia and Analgesia. 115: 638-62. PMID 22798528 DOI: 10.1213/ANE.0b013e31826253f2  0.257
1995 Hood DD, Eisenach JC, Tong C, Tommasi E, Yaksh TL. Cardiorespiratory and spinal cord blood flow effects of intrathecal neostigmine methylsulfate, clonidine, and their combination in sheep. Anesthesiology. 82: 428-35. PMID 7856901  0.256
1981 Hammond DL, Yaksh TL. Peripheral and central pathways in pain Pharmacology and Therapeutics. 14: 459-475. PMID 7323138 DOI: 10.1016/0163-7258(81)90038-3  0.256
1996 Galik J, Marsala M, Yaksh TL. Changes in spontaneous unit activity in lumbar spinal cord after reversible aortic occlusion in the rat. Neuroscience Letters. 207: 45-8. PMID 8710206  0.256
2012 Christianson CA, Fitzsimmons BL, Shim JH, Agrawal A, Cohen SM, Hua XY, Yaksh TL. Spinal matrix metalloproteinase 3 mediates inflammatory hyperalgesia via a tumor necrosis factor-dependent mechanism. Neuroscience. 200: 199-210. PMID 22056600 DOI: 10.1016/J.Neuroscience.2011.10.019  0.256
1994 Yaksh TL, Pogrel JM, Lee Y-, Chaplan S. Spinal α2 Agonists Reverse Nerve Ligation-induced Allodynia Anesthesiology. 81: A938. DOI: 10.1097/00000542-199409001-00937  0.255
1989 Yaksh TL, Chipkin RE. Studies on the effect of SCH-34826 and thiorphan on [Met5]enkephalin levels and release in rat spinal cord. European Journal of Pharmacology. 167: 367-73. PMID 2806377 DOI: 10.1016/0014-2999(89)90445-7  0.255
1987 Durant PC, Yaksh T. DRUG EFFECTS ON URINARY BLADDER TONE DURING SPINAL MORPHINE-INDUCED INHIBITION OF THE MICTURITION REFLEX IN UNANESTHETIZED RATS Anesthesiology. 67: A675-A675. DOI: 10.1097/00000542-198709001-00675  0.255
2023 Yaksh TL, Santos GGD, Borges Paes Lemes J, Malange K. Neuraxial drug delivery in pain management: An overview of past, present, and future. Best Practice & Research. Clinical Anaesthesiology. 37: 243-265. PMID 37321769 DOI: 10.1016/j.bpa.2023.04.003  0.255
1999 Luo ZD, Chaplan SR, Scott BP, Cizkova D, Calcutt NA, Yaksh TL. Neuronal nitric oxide synthase mRNA upregulation in rat sensory neurons after spinal nerve ligation: lack of a role in allodynia development. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 9201-8. PMID 10531423 DOI: 10.1523/Jneurosci.19-21-09201.1999  0.255
2004 Eisenach JC, Hood DD, Curry R, Sawynok J, Yaksh TL, Li X. Intrathecal but not intravenous opioids release adenosine from the spinal cord. The Journal of Pain : Official Journal of the American Pain Society. 5: 64-8. PMID 14975380 DOI: 10.1016/j.jpain.2003.10.001  0.255
2009 Hua XY, Yaksh TL. Dorsal horn substance P and NK1 receptors: Study of a model system in spinal nociceptive processing Synaptic Plasticity in Pain. 109-138. DOI: 10.1007/978-1-4419-0226-9_6  0.254
1992 Herold EE, Yaksh TL. Anesthesia and muscle relaxation with intrathecal injections of AR636 and AG489, two acylpolyamine spider toxins, in rat. Anesthesiology. 77: 507-12. PMID 1519789 DOI: 10.1097/00000542-199209000-00016  0.254
2000 Wallace MS, Ridgeway BM, Leung AY, Gerayli A, Yaksh TL. Concentration-effect relationship of intravenous lidocaine on the allodynia of complex regional pain syndrome types I and II. Anesthesiology. 92: 75-83. PMID 10638902  0.254
2002 Wallace MS, Ridgeway B, Leung A, Schulteis G, Yaksh TL. Concentration-effect relationships for intravenous alfentanil and ketamine infusions in human volunteers: effects on acute thresholds and capsaicin-evoked hyperpathia. Journal of Clinical Pharmacology. 42: 70-80. PMID 11808827 DOI: 10.1177/0091270002042001008  0.253
2014 Wiese AJ, Yaksh TL. Nociception and Pain Mechanisms Handbook of Veterinary Pain Management: Third Edition. 10-41. DOI: 10.1016/B978-0-323-08935-7.00002-8  0.252
1980 Yaksh TL. Pain and analgesia pharmacology of the nociceptive feedback loop Anaesthesia and Intensive Care. 8: 368.  0.252
1987 Yaksh TL. Opioid receptor systems and the endorphins: A review of their spinal organization Journal of Neurosurgery. 67: 157-176. PMID 3037042  0.251
2006 Allen JW, Mantyh PW, Horais K, Tozier N, Rogers SD, Ghilardi JR, Cizkova D, Grafe MR, Richter P, Lappi DA, Yaksh TL. Safety evaluation of intrathecal substance P-saporin, a targeted neurotoxin, in dogs. Toxicological Sciences : An Official Journal of the Society of Toxicology. 91: 286-98. PMID 16500924 DOI: 10.1093/Toxsci/Kfj143  0.251
1993 Abram SE, Yaksh TL. Morphine, but not inhalation anesthesia, blocks post-injury facilitation. The role of preemptive suppression of afferent transmission. Anesthesiology. 78: 713-21. PMID 8385425 DOI: 10.1097/00000542-199304000-00015  0.251
1997 Wallace MS, Laitin S, Licht D, Yaksh TL. Concentration-effect relations for intravenous lidocaine infusions in human volunteers: effects on acute sensory thresholds and capsaicin-evoked hyperpathia. Anesthesiology. 86: 1262-72. PMID 9197294  0.251
1991 Carpenter R, Nepom G, Yaksh T, Yamamoto T. SCIATIC NERVE LIGATION INCREASES mRNA CODING FOR SUBSTANCE P AND DYNORPHIN IN RAT SPINAL CORD Anesthesiology. 75: A1089-A1089. DOI: 10.1097/00000542-199109001-01088  0.25
1990 Onofrio BM, Yaksh TL. Long-term pain relief produced by intrathecal morphine infusion in 53 patients Journal of Neurosurgery. 72: 200-209. PMID 1688618  0.25
2022 Lee HJ, Remacle AG, Hullugundi SK, Dolkas J, Leung JB, Chernov AV, Yaksh TL, Strongin AY, Shubayev VI. Sex-Specific B Cell and Anti-Myelin Autoantibody Response After Peripheral Nerve Injury. Frontiers in Cellular Neuroscience. 16: 835800. PMID 35496906 DOI: 10.3389/fncel.2022.835800  0.25
1990 Benarroch EE, Aimone LD, Yaksh TL. Segmental analysis of neuropeptide concentrations in normal human spinal cord. Neurology. 40: 137-44. PMID 2296359 DOI: 10.1212/WNL.40.1.137  0.25
1998 Dirig DM, Isakson PC, Yaksh TL. Effect of COX-1 and COX-2 inhibition on induction and maintenance of carrageenan-evoked thermal hyperalgesia in rats. The Journal of Pharmacology and Experimental Therapeutics. 285: 1031-8. PMID 9618405  0.249
2002 Hua XY, Moore A, Malkmus S, Murray SF, Dean N, Yaksh TL, Butler M. Inhibition of spinal protein kinase Calpha expression by an antisense oligonucleotide attenuates morphine infusion-induced tolerance. Neuroscience. 113: 99-107. PMID 12123688 DOI: 10.1016/S0306-4522(02)00157-4  0.249
1981 Russell B, Yaksh TL. Antagonism by phenoxybenzamine and pentazocine of the antinociceptive effects of morphine in the spinal cord Neuropharmacology. 20: 575-579. PMID 6894633 DOI: 10.1016/0028-3908(81)90210-0  0.249
2004 Yaksh TL, Horais KA, Tozier N, Rathbun M, Richter P, Rossi S, Grafe M, Tong C, Meschter C, Cline JM, Eisenach J. Intrathecal ketorolac in dogs and rats. Toxicological Sciences : An Official Journal of the Society of Toxicology. 80: 322-34. PMID 15141096 DOI: 10.1093/Toxsci/Kfh168  0.249
1980 Yaksh TL, Tyce GM. Resting and K+-evoked release of serotonin and norepine- phrine in vivo from the rat and cat spinal cord Brain Research. 192: 133-146. PMID 7378777 DOI: 10.1016/0006-8993(80)91014-8  0.248
2017 Knezevic NN, Yekkirala A, Yaksh TL. Basic/Translational Development of Forthcoming Opioid- and Nonopioid-Targeted Pain Therapeutics. Anesthesia and Analgesia. 125: 1714-1732. PMID 29049116 DOI: 10.1213/ANE.0000000000002442  0.248
1990 Thomforde GM, Malagelada JR, Camilleri M, Yaksh TL. Demonstration of intrathecal and systemic morphine and ST-91 effects on fed canine upper gut motility. Digestive Diseases and Sciences. 35: 1249-56. PMID 1976496 DOI: 10.1007/BF01536415  0.246
1988 Yaksh TL. CNS mechanisms of pain and analgesia Cancer Surveys. 7: 5-28. PMID 2838170  0.246
1994 Malmberg AB, Yaksh TL. Capsaicin-evoked prostaglandin E2 release in spinal cord slices: relative effect of cyclooxygenase inhibitors. European Journal of Pharmacology. 271: 293-9. PMID 7705429 DOI: 10.1016/0014-2999(94)90786-2  0.246
1983 Yaksh TL. The principles behind the use of spinal narcotics Clinics in Anaesthesiology. 1: 219-232.  0.245
1991 Lucas D, Yaksh TL. Release in vivo of Met-enkephalin and encrypted forms of Met-enkephalin from brain and spinal cord of the anesthetized cat. Peptides. 11: 1119-25. PMID 2087436 DOI: 10.1016/0196-9781(90)90140-Z  0.245
1998 Jun JH, Yaksh TL. The effect of intrathecal gabapentin and 3-isobutyl gamma-aminobutyric acid on the hyperalgesia observed after thermal injury in the rat. Anesthesia and Analgesia. 86: 348-54. PMID 9459247 DOI: 10.1097/00000539-199802000-00025  0.245
1987 Yaksh TL, Durant PA, Gaumann DM, Stevens CW, Mjanger E. Issues in drug management. Part 2. The use of receptor-selective agents as analgesics in the spinal cord: trends and possibilities. Journal of Pain and Symptom Management. 2: 129-38. PMID 3039016 DOI: 10.1016/S0885-3924(87)80071-4  0.245
2012 Deer TR, Prager J, Levy R, Burton A, Buchser E, Caraway D, Cousins M, De Andrés J, Diwan S, Erdek M, Grigsby E, Huntoon M, Jacobs M, Kim P, Kumar K, ... ... Yaksh T, et al. Polyanalgesic Consensus Conference--2012: recommendations on trialing for intrathecal (intraspinal) drug delivery: report of an interdisciplinary expert panel. Neuromodulation : Journal of the International Neuromodulation Society. 15: 420-35; discussion 4. PMID 22494357 DOI: 10.1111/j.1525-1403.2012.00450.x  0.245
2002 Nozaki-Taguchi N, Yaksh TL. Pharmacology of spinal glutamatergic receptors in post-thermal injury-evoked tactile allodynia and thermal hyperalgesia. Anesthesiology. 96: 617-26. PMID 11873037 DOI: 10.1097/00000542-200203000-00018  0.245
2002 Rossi S, Yaksh T. Rapid quantification of the delta-opioid receptor selective enkephalin DPDPE in canine cerebrospinal fluid by liquid chromatography--mass spectrometry. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 772: 73-9. PMID 12016017 DOI: 10.1016/S1570-0232(02)00058-2  0.245
1983 Yaksh TL. Effects of spinally administered agents on spinal cord blood flow: A need for further studies Anesthesiology. 59: 173-174. PMID 6688331  0.244
1984 Yaksh TL. Multiple opioid receptor systems in brain and spinal cord: Part 2 European Journal of Anaesthesiology. 1: 201-243. PMID 6152614  0.244
1991 Takano Y, Yaksh T. Agonist and Antagonist Pharmacology of the Antinociceptive Effect of Spinally Administered α2 Agonists Anesthesiology. 75: A630-A630. DOI: 10.1097/00000542-199109001-00629  0.243
1988 Yaksh TL, Harty GJ. Pharmacology of the allodynia in rats evoked by high dose intrathecal morphine Journal of Pharmacology and Experimental Therapeutics. 244: 501-507. PMID 3346833  0.243
1992 Yamamoto T, Yaksh TL. Comparison of the antinociceptive effects of pre- and posttreatment with intrathecal morphine and MK801, an NMDA antagonist, on the formalin test in the rat Anesthesiology. 77: 757-763. PMID 1416174 DOI: 10.1097/00000542-199210000-00021  0.243
2008 Ray SB, Yaksh TL. Spinal antinociceptive action of loperamide is mediated by opioid receptors in the formalin test in rats. Neuroscience Letters. 448: 260-2. PMID 18973791 DOI: 10.1016/j.neulet.2008.10.067  0.243
2007 Zanella J, Hildebrand K, Burright E, McKay B, Yaksh T. 172 COMPARING LOCAL DELIVERY OF KETOROLAC AND PENTOXIFYLLINE IN THE CHUNG AND BENNETT RAT MODELS OF NEUROPATHIC PAIN European Journal of Pain. 11: S74-S75. DOI: 10.1016/j.ejpain.2007.03.187  0.243
2017 Flinspach M, Xu Q, Piekarz AD, Fellows R, Hagan R, Gibbs A, Liu Y, Neff RA, Freedman J, Eckert WA, Zhou M, Bonesteel R, Pennington MW, Eddinger KA, Yaksh TL, et al. Insensitivity to pain induced by a potent selective closed-state Nav1.7 inhibitor. Scientific Reports. 7: 39662. PMID 28045073 DOI: 10.1038/srep39662  0.243
2010 Usvald D, Vodicka P, Hlucilova J, Prochazka R, Motlik J, Kuchorova K, Johe K, Marsala S, Scadeng M, Kakinohana O, Navarro R, Santa M, Hefferan MP, Yaksh TL, Marsala M. Analysis of dosing regimen and reproducibility of intraspinal grafting of human spinal stem cells in immunosuppressed minipigs. Cell Transplantation. 19: 1103-22. PMID 20412634 DOI: 10.3727/096368910X503406  0.243
1989 Ramberg DA, Yaksh TL. Effects of cervical spinal hemisection on dihydromorphine binding in brainstem and spinal cord in cat. Brain Research. 483: 61-7. PMID 2539891 DOI: 10.1016/0006-8993(89)90034-6  0.242
1983 Yaksh TL, Terenius L, Nyberg F, Jhamandas K, Wang JY. Studies on the release by somatic stimulation from rat and cat spinal cord of active materials which displace dihydromorphine in an opiate-binding assay. Brain Research. 268: 119-28. PMID 6860955 DOI: 10.1016/0006-8993(83)90396-7  0.241
1992 Yamamoto T, Yaksh TL. Spinal pharmacology of thermal hyperesthesia induced by constriction injury of sciatic nerve. Excitatory amino acid antagonists Pain. 49: 121-128. PMID 1594273 DOI: 10.1016/0304-3959(92)90198-K  0.241
1994 Sabbe MB, Penning JP, Ozaki GT, Yaksh TL. Spinal and systemic action of the alpha 2 receptor agonist dexmedetomidine in dogs. Antinociception and carbon dioxide response. Anesthesiology. 80: 1057-72. PMID 7912480 DOI: 10.1097/00000542-199405000-00015  0.241
1997 Khan IM, Yaksh TL, Taylor P. Epibatidine binding sites and activity in the spinal cord. Brain Research. 753: 269-82. PMID 9125412 DOI: 10.1016/S0006-8993(97)00031-0  0.241
1991 Patel P, Drummond J, Mitchell M, Yaksh T, Cole D. REGIONAL RECOVERY OF EICOSANOIDS AFTER FOREBRAIN ISCHEMIA BY MICRODIALYSIS IN RATS Anesthesiology. 75: A628. DOI: 10.1097/00000542-199109001-00627  0.241
2022 Li X, Li Q, Song S, Stevens AO, Broemmel Z, He Y, Wesselmann U, Yaksh T, Zhao C. Emulsion-induced polymersomes taming tetrodotoxin for prolonged duration local anesthesia. Advanced Therapeutics. 6. PMID 36819711 DOI: 10.1002/adtp.202200199  0.24
2008 Nazarian A, Christianson CA, Hua XY, Yaksh TL. Dexmedetomidine and ST-91 analgesia in the formalin model is mediated by alpha2A-adrenoceptors: a mechanism of action distinct from morphine. British Journal of Pharmacology. 155: 1117-26. PMID 18846040 DOI: 10.1038/bjp.2008.341  0.24
2006 Kakinohana O, Hefferan MP, Nakamura S, Kakinohana M, Galik J, Tomori Z, Marsala J, Yaksh TL, Marsala M. Development of GABA-sensitive spasticity and rigidity in rats after transient spinal cord ischemia: a qualitative and quantitative electrophysiological and histopathological study. Neuroscience. 141: 1569-83. PMID 16797137 DOI: 10.1016/j.neuroscience.2006.04.083  0.24
1994 Sabbe MB, Grafe MR, Mjanger E, Tiseo PJ, Hill HF, Yaksh TL. Spinal delivery of sufentanil, alfentanil, and morphine in dogs. Physiologic and toxicologic investigations. Anesthesiology. 81: 899-920. PMID 7943841 DOI: 10.1097/00000542-199410000-00017  0.239
1997 Dirig DM, Yaksh TL. Hyperalgesia-associated spinal synthesis and release of prostaglandins. Advances in Experimental Medicine and Biology. 433: 205-8. PMID 9561136  0.239
1990 Yaksh TL. The analgesic pharmacology of spinally administered mu opioid agonists Schmerz Pain Douleur. 11: 66-71.  0.239
1981 Yaksh TL, Reddy SV. Studies in the primate on the analgetic effects associated with intrathecal actions of opiates, α-adrenergic agonists and baclofen Anesthesiology. 54: 451-467. PMID 6112935  0.238
2019 Ramachandran R, Wang Z, Saavedra C, Corr M, DiNardo A, Powell SB, Yaksh T. [EXPRESS] Role of Toll-like receptor 4 signaling in mast cell mediated trigeminal pain pathway. Molecular Pain. 1744806919867842. PMID 31342858 DOI: 10.1177/1744806919867842  0.238
1995 Dirig DM, Yaksh TL. Intrathecal baclofen and muscimol, but not midazolam, are antinociceptive using the rat-formalin model. The Journal of Pharmacology and Experimental Therapeutics. 275: 219-27. PMID 7562553  0.238
2000 Yaksh T, Birnbach DJ. Intrathecal nalbuphine after cesarean delivery: are we ready? Anesthesia and Analgesia. 91: 505-8. PMID 10960366 DOI: 10.1097/00000539-200009000-00001  0.238
2014 Yaksh TL, Hobo S, Peters C, Osborn KG, Richter PJ, Rossi SS, Grafe MR, Eisenach JC. Preclinical toxicity screening of intrathecal oxytocin in rats and dogs. Anesthesiology. 120: 951-61. PMID 24492326 DOI: 10.1097/Aln.0000000000000148  0.238
1990 Waldman SD, Yaksh TL. Spinal opioids: historical perspectives and future directions. Introduction Journal of Pain and Symptom Management. 5: 137. PMID 2366007 DOI: 10.1016/0885-3924(90)90001-Z  0.238
2006 Leung AY, Park J, Schulteis G, Duann JR, Yaksh T. The electrophysiology of de qi sensations. Journal of Alternative and Complementary Medicine (New York, N.Y.). 12: 743-50. PMID 17034280 DOI: 10.1089/acm.2006.12.743  0.237
1992 Malmberg AB, Yaksh TL. ANTINOCICEPTIVE EFFECTS OF INTRATHECAL NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs) ON TONIC PAIN BEHAVIOR IN RATS Anesthesiology. 77: A732. DOI: 10.1097/00000542-199209001-00732  0.237
2014 Ishikawa T, Suzuki H, Ishikawa K, Yasuda S, Matsui T, Yamamoto M, Kakeda T, Yamamoto S, Owada Y, Yaksh TL. Spinal cord ischemia/injury. Current Pharmaceutical Design. 20: 5738-43. PMID 24502574  0.237
1993 Malmberg AB, Yaksh TL. Pharmacology of the spinal action of ketorolac, morphine, ST-91, U50488H, and L-PIA on the formalin test and an isobolographic analysis of the NSAID interaction Anesthesiology. 79: 270-281. PMID 8102041  0.237
1992 Yamamoto T, Yaksh TL. Effects of intrathecal capsaicin and an NK-1 antagonist, CP,96-345, on the thermal hyperalgesia observed following unilateral constriction of the sciatic nerve in the rat Pain. 51: 329-334. PMID 1337198 DOI: 10.1016/0304-3959(92)90218-Z  0.236
2021 D'Arcy Y, Mantyh P, Yaksh T, Donevan S, Hall J, Sadrarhami M, Viktrup L. Treating osteoarthritis pain: mechanisms of action of acetaminophen, nonsteroidal anti-inflammatory drugs, opioids, and nerve growth factor antibodies. Postgraduate Medicine. 1-16. PMID 34252357 DOI: 10.1080/00325481.2021.1949199  0.236
1990 Sosnowski M, Yaksh T. Time-course of physical abstinence and tolerance recovery after spinal continuous infusion of μ agonists in the rat Pain. 41: S127. DOI: 10.1016/0304-3959(90)92391-3  0.236
2003 Rossi S, Yaksh T. Rapid quantification of the non-competitive NMDA antagonist MK-801 in canine cerebrospinal fluid and plasma by capillary gas chromatography-nitrogen phosphorus detection. Journal of Pharmaceutical and Biomedical Analysis. 31: 243-50. PMID 12609663 DOI: 10.1016/S0731-7085(02)00603-9  0.236
2006 Yaksh TL. Calcium channels as therapeutic targets in neuropathic pain. The Journal of Pain : Official Journal of the American Pain Society. 7: S13-30. PMID 16426997 DOI: 10.1016/j.jpain.2005.09.007  0.236
2013 Takasusuki T, Yamaguchi S, Hamaguchi S, Yaksh TL. Effects of general anesthetics on substance P release and c-Fos expression in the spinal dorsal horn. Anesthesiology. 119: 433-42. PMID 23708866 DOI: 10.1097/ALN.0b013e31829996b6  0.236
1998 Buerkle H, Yaksh TL. Pharmacological evidence for different alpha 2-adrenergic receptor sites mediating analgesia and sedation in the rat. British Journal of Anaesthesia. 81: 208-15. PMID 9813525  0.236
1997 Yaksh TL. Physiology and pharmacology of the postinjury pain state Seminars in Anesthesia. 16: 79-91. DOI: 10.1016/S0277-0326(97)80019-0  0.235
1983 Bergstrom L, Hammond DL, Go VLW, Yaksh TL. Concurrent measurement of substance P and serotonin in spinal superfusates: failure of capsaicin and p-chloroamphetamine to co-release Brain Research. 270: 181-184. PMID 6191841 DOI: 10.1016/0006-8993(83)90812-0  0.235
2011 Huang PP, Khan I, Suhail MSA, Malkmus S, Yaksh TL. Correction: Spinal Botulinum Neurotoxin B: Effects on Afferent Transmitter Release and Nociceptive Processing Plos One. 6. DOI: 10.1371/annotation/7b989904-0cf4-4f2d-9626-6bf3ef6646c5  0.235
2011 Huang PP, Khan I, Suhail MSA, Malkmus S, Yaksh TL. Correction: Spinal Botulinum Neurotoxin B: Effects on Afferent Transmitter Release and Nociceptive Processing Plos One. 6. DOI: 10.1371/ANNOTATION/1FE31FA2-E930-4A72-A208-64EB42D99F02  0.235
1988 Stoddard SL, Tyce GM, Carmichael SW, Gaumann DM, Yaksh TL. Effect of acute and chronic spinal transection on evoked secretion of adrenal medullary catecholamines in the cat Journal of the Autonomic Nervous System. 23: 175-179. PMID 3171091 DOI: 10.1016/0165-1838(88)90081-1  0.235
1993 Takano Y, Yaksh TL. Chronic spinal infusion of dexmedetomidine, ST-91 and clonidine: Spinal alpha2 adrenoceptor subtypes and intrinsic activity Journal of Pharmacology and Experimental Therapeutics. 264: 327-335. PMID 8093729  0.234
1991 Yamamoto T, Yaksh T. EFFECTS OF TOPICAL COLCHICINE AND SPINAL CAPSAICIN ON THERMAL HYPERESTHESIA IN A COMPRESSION MONONEUROPATHY MODEL Anesthesiology. 75: A599-A599. DOI: 10.1097/00000542-199109001-00598  0.234
2005 Malkmus S, Lu X, Bartfai T, Yaksh TL, Hua XY. Increased hyperalgesia after tissue injury and faster recovery of allodynia after nerve injury in the GalR1 knockout mice. Neuropeptides. 39: 217-21. PMID 15944015 DOI: 10.1016/J.Npep.2004.12.002  0.234
1979 Wilson PR, Yaksh TL. Baclofen is antinociceptive in the spinal intrathecal space of animals. European Journal of Pharmacology. 51: 323-30. PMID 581376 DOI: 10.1016/0014-2999(78)90423-5  0.234
1994 Lee YW, Yaksh TL. Isobolographic Analysis of Interaction between Intrathecal Clonidine and MK-801 in Rat Neuropathic Pain Model Anesthesiology. 81: A935. DOI: 10.1097/00000542-199409001-00934  0.233
2017 Yaksh TL, Schwarcz R, Snodgrass HR. Characterization of the effects of L-4-chlorokynurenine on nociception in rodents. The Journal of Pain : Official Journal of the American Pain Society. PMID 28428091 DOI: 10.1016/j.jpain.2017.03.014  0.233
2002 Luger NM, Sabino MA, Schwei MJ, Mach DB, Pomonis JD, Keyser CP, Rathbun M, Clohisy DR, Honore P, Yaksh TL, Mantyh PW. Efficacy of systemic morphine suggests a fundamental difference in the mechanisms that generate bone cancer vs inflammatory pain. Pain. 99: 397-406. PMID 12406514 DOI: 10.1016/S0304-3959(02)00102-1  0.233
1995 Yaksh TL, Grafe MR, Malkmus S, Rathbun ML, Eisenach JC. Studies on the safety of chronically administered intrathecal neostigmine methylsulfate in rats and dogs. Anesthesiology. 82: 412-27. PMID 7856900 DOI: 10.1097/00000542-199502000-00012  0.233
1990 Solomon R, Aimone L, Yaksh T, Gebharti G. Release of putative peptide and amino acid nociceptive transmitters from rat spinal cord in vitro Pain. 41: S174. DOI: 10.1016/0304-3959(90)92485-9  0.233
1995 Rothrock JF, Mar KR, Yaksh TL, Golbeck A, Moore AC. Cerebrospinal fluid analyses in migraine patients and controls. Cephalalgia : An International Journal of Headache. 15: 489-93. PMID 8706112 DOI: 10.1046/J.1468-2982.1995.1506489.X  0.233
1993 Yamamoto T, Yaksh TL. Effects of intrathecal strychnine and bicuculline on nerve compression-induced thermal hyperalgesia and selective antagonism by MK-801 Pain. 54: 79-84. PMID 8378105 DOI: 10.1016/0304-3959(93)90102-U  0.233
1999 Dirig DM, Yaksh TL. Spinal synthesis and release of prostanoids after peripheral injury and inflammation. Advances in Experimental Medicine and Biology. 469: 401-8. PMID 10667359  0.231
1988 Go VL, Yaksh TL. Release of substance P from the cat spinal cord. The Journal of Physiology. 391: 141-67. PMID 2451003 DOI: 10.1113/jphysiol.1987.sp016731  0.23
2019 Miller YI, Navia-Pelaez JM, Corr M, Yaksh TL. Lipid rafts in glial cells: Role in neuroinflammation and pain processing. Journal of Lipid Research. PMID 31862695 DOI: 10.1194/jlr.TR119000468  0.23
1997 Naguib M, Yaksh TL. Characterization of muscarinic receptor subtypes that mediate antinociception in the rat spinal cord. Anesthesia and Analgesia. 85: 847-53. PMID 9322468 DOI: 10.1097/00000539-199710000-00025  0.23
1996 Wallace MS, Dyck JB, Rossi SS, Yaksh TL. Computer-controlled lidocaine infusion for the evaluation of neuropathic pain after peripheral nerve injury. Pain. 66: 69-77. PMID 8857633  0.23
1982 ONOFRIO BM, YAKSH TL, ARNOLD PG, Bridenbaugh LD. Continuous Low-Dose Intrathecal Morphine Administration in the Treatment of Chronic Pain of Malignant Origin Survey of Anesthesiology. 26: 110. DOI: 10.1097/00132586-198204000-00060  0.229
1982 ONOFRIO BM, YAKSH TL, ARNOLD PG. Continuous Low-dose Intrathecal Morphine Administration in the Treatment of Chronic Pain of Malignant Origin Obstetrical & Gynecological Survey. 37: 270-271. DOI: 10.1097/00006254-198204000-00023  0.229
1988 Karmeli R, Nitecki S, Yaksh T, Schmalz P, Szurszewski JH. Sulphated CCK-OP administered centrally in dogs converts the fasting pattern of gastrointestinal electrical activity to the fed pattern☆ Regulatory Peptides. 22: 413. DOI: 10.1016/0167-0115(88)90168-1  0.229
1982 Taylor JE, Yaksh TL, Richelson E. Histamine H1 receptors in the brain and spinal cord of the cat. Brain Research. 243: 391-4. PMID 7104749 DOI: 10.1016/0006-8993(82)90268-2  0.229
2008 Ilieva HS, Yamanaka K, Malkmus S, Kakinohana O, Yaksh T, Marsala M, Cleveland DW. Mutant dynein (Loa) triggers proprioceptive axon loss that extends survival only in the SOD1 ALS model with highest motor neuron death. Proceedings of the National Academy of Sciences of the United States of America. 105: 12599-604. PMID 18719118 DOI: 10.1073/Pnas.0805422105  0.228
1992 Bernards CM, Luger TJ, Malmberg AB, Hill HF, Yaksh TL. Liposome encapsulation prolongs alfentanil spinal analgesia and alters systemic redistribution in the rat. Anesthesiology. 77: 529-35. PMID 1519790 DOI: 10.1097/00000542-199209000-00019  0.228
1988 YAKSH T. Spinal Administration of Somatostatin in Animals and Humans Anesthesiology. 69: 809-810. DOI: 10.1097/00000542-198811000-00051  0.228
1992 Yaksh TL. The spinal pharmacology of acutely and chronically administered opioids Journal of Pain and Symptom Management. 7: 356-361. PMID 1325528 DOI: 10.1016/0885-3924(92)90089-Z  0.228
2018 Unger MD, Pleticha J, Steinauer J, Kanwar R, Diehn F, LaVallee KT, Banck MS, Jones B, Yaksh TL, Maus TP, Beutler AS. Unilateral Epidural Targeting of Resiniferatoxin Induces Bilateral Neurolysis of Spinal Nociceptive Afferents. Pain Medicine (Malden, Mass.). PMID 30590777 DOI: 10.1093/pm/pny276  0.227
1999 DeHaven-Hudkins DL, Burgos LC, Cassel JA, Daubert JD, DeHaven RN, Mansson E, Nagasaka H, Yu G, Yaksh T. Loperamide (ADL 2-1294), an opioid antihyperalgesic agent with peripheral selectivity. The Journal of Pharmacology and Experimental Therapeutics. 289: 494-502. PMID 10087042  0.227
1989 Gaumann DM, Yaksh TL, Wilcox GL, Rodriguez M. Intrathecal somatostatin in cat and mouse studies on pain, motor behavior, and histopathology Anesthesia and Analgesia. 68: 623-632. PMID 2566288  0.227
1999 Yoon MH, Yaksh TL. The effect of intrathecal gabapentin on pain behavior and hemodynamics on the formalin test in the rat. Anesthesia and Analgesia. 89: 434-9. PMID 10439761  0.227
1977 Yaksh TL, Rudy TA. Studies on the direct spinal action of narcotics in the production of analgesia in the rat Journal of Pharmacology and Experimental Therapeutics. 202: 411-428. PMID 18600  0.226
2020 Miller YI, Navia-Pelaez JM, Corr M, Yaksh TL. Lipid rafts in glial cells: role in neuroinflammation and pain processing: Thematic Review Series: Biology of Lipid Rafts. Journal of Lipid Research. 61: 655-666. PMID 33715813 DOI: 10.1194/jlr.TR119000468  0.226
2010 Eisenach JC, Shafer SL, Yaksh T. The need for a journal policy on intrathecal, epidural, and perineural administration of non-approved drugs. Pain. 149: 417-9. PMID 20227830 DOI: 10.1016/j.pain.2010.02.028  0.225
1989 Aimone LD, Yaksh TL. Opioid modulation of capsaicin-evoked release of substance P from rat spinal cord in vivo Peptides. 10: 1127-1131. PMID 2482963 DOI: 10.1016/0196-9781(89)90003-X  0.225
1989 Go VL, Yaksh TL. Quantification of bombesin-like peptides in mammalian spinal cord. Annals of the New York Academy of Sciences. 547: 70-5. PMID 3239896 DOI: 10.1111/j.1749-6632.1988.tb23876.x  0.225
1981 Hammond DL, Yaksh TL, Tyce GM. Presence of Conjugated 5‐Hydroxytryptamine in In Vivo Superfusates of Rat Spinal Cord Journal of Neurochemistry. 37: 1068-1071. PMID 6172561 DOI: 10.1111/J.1471-4159.1981.Tb04501.X  0.225
1990 Oshita S, Yaksh TL, Chipkin R. The antinociceptive effects of intrathecally administered SCH32615, an enkephalinase inhibitor in the rat. Brain Research. 515: 143-8. PMID 2357551 DOI: 10.1016/0006-8993(90)90588-3  0.225
2002 Yaksh TL. Future advances in pain pharmacology: what does the present say about the future? Proceedings of the Western Pharmacology Society. 45: 211-8. PMID 12434582  0.224
2002 Eisenach JC, Yaksh TL. Safety in numbers: how do we study toxicity of spinal analgesics? Anesthesiology. 97: 1047-9. PMID 12411784 DOI: 10.1097/00000542-200211000-00003  0.224
1997 Ibuki T, Dunbar SA, Yaksh TL. Effect of transient naloxone antagonism on tolerance development in rats receiving continuous spinal morphine infusion. Pain. 70: 125-32. PMID 9150285  0.224
1993 Takano M, Takano Y, Yaksh TL. Release of calcitonin gene-related peptide (CGRP), substance P (SP), and vasoactive intestinal polypeptide (VIP) from rat spinal cord: modulation by alpha 2 agonists. Peptides. 14: 371-8. PMID 7683402 DOI: 10.1016/0196-9781(93)90055-L  0.223
1993 Malmberg AB, Yaksh TL. Spinal nitric oxide synthesis inhibition blocks NMDA-induced thermal hyperalgesia and produces antinociception in the formalin test in rats Pain. 54: 291-300. PMID 8233543 DOI: 10.1016/0304-3959(93)90028-N  0.223
1996 Nagasaka H, Awad H, Yaksh TL. Peripheral and spinal actions of opioids in the blockade of the autonomic response evoked by compression of the inflamed knee joint. Anesthesiology. 85: 808-16. PMID 8873551  0.223
1994 Sanghvi R, Yaksh TL. SPINAL AMINO ACID RELEASE EVOKED BY PAW FORMATION IN UNANESTHETIZED AND HALOTHANE ANESTHETIZED RATS Anesthesiology. 81: A837. DOI: 10.1097/00000542-199409001-00836  0.223
1993 Malmberg AB, Yaksh TL. Spinal actions of non-steroidal anti-inflammatory drugs: Evidence for a central role of prostanoids in nociceptive processing Progress in Pharmacology and Clinical Pharmacology. 10: 91-110.  0.223
1997 Dirig DM, Isakson PC, Yaksh TL. A721 SPINAL AND SYSTEMIC CYCLOOXYGENASE (COX) INHIBITORS SUPPRESS PAW CARRAGEENAN-EVOKED THERMAL HYPERALGESIA IN RATS Anesthesiology. 87: 721A. DOI: 10.1097/00000542-199709001-00721  0.222
1993 Myers RR, Yamamoto T, Yaksh TL, Powell HC. The role of focal nerve ischemia and Wallerian degeneration in peripheral nerve injury producing hyperesthesia. Anesthesiology. 78: 308-16. PMID 8439027 DOI: 10.1097/00000542-199302000-00015  0.222
2000 Ishikawa T, Marsala M, Sakabe T, Yaksh TL. Characterization of spinal amino acid release and touch-evoked allodynia produced by spinal glycine or GABA(A) receptor antagonist. Neuroscience. 95: 781-6. PMID 10670445  0.222
1995 Calcutt NA, Li L, Yaksh TL, Malmberg AB. Different effects of two aldose reductase inhibitors on nociception and prostaglandin E. European Journal of Pharmacology. 285: 189-97. PMID 8566138 DOI: 10.1016/0014-2999(95)00402-7  0.221
1997 Yaksh TL, Wallace MS. Advances in pain research Anesthesiology Clinics of North America. 15: 229-234. DOI: 10.1016/S0889-8537(05)70330-8  0.221
1984 Yaksh TL. Multiple opioid receptor systems in brain and spinal cord: Part I European Journal of Anaesthesiology. 1: 171-199. PMID 6152613  0.221
1996 Zhang Y, Malmberg AB, Sjölund B, Yaksh TL. The effect of pituitary adenylate cyclase activating peptide (PACAP) on the nociceptive formalin test. Neuroscience Letters. 207: 187-90. PMID 8728481  0.22
1985 Camarata PJ, Yaksh TL. Characterization of the spinal adrenergic receptors mediating the spinal effects produced by the microinjection of morphine into the periaqueductal gray Brain Research. 336: 133-142. PMID 2988700 DOI: 10.1016/0006-8993(85)90424-X  0.22
1977 Rudy TA, Yaksh TL. Hyperthermic effects of morphine: set point manipulation by a direct spinal action. British Journal of Pharmacology. 61: 91-6. PMID 912212  0.219
1992 Takano Y, Takano M, Yaksh TL. The effect of intrathecally administered imiloxan and WB4101: possible role of alpha 2-adrenoceptor subtypes in the spinal cord. European Journal of Pharmacology. 219: 465-8. PMID 1358645 DOI: 10.1016/0014-2999(92)90490-U  0.218
2013 Wiese AJ, Rathbun M, Butt MT, Malkmus SA, Richter PJ, Osborn KG, Xu Q, Veesart SL, Steinauer JJ, Higgins D, Lappi DA, Russell B, Yaksh TL. Intrathecal substance P-saporin in the dog: distribution, safety, and spinal neurokinin-1 receptor ablation. Anesthesiology. 119: 1163-77. PMID 24051388 DOI: 10.1097/ALN.0b013e3182a95164  0.218
1984 Hammond DL, Yaksh TL. Antagonism of stimulation-produced antinociception by intrathecal administration of methysergide or phentolamine Brain Research. 298: 329-337. PMID 6326954 DOI: 10.1016/0006-8993(84)91432-X  0.218
2000 Yaksh TL. Analgesics, pain and tolerance: The St John's discussion Pain Research and Management. 5: 19-22.  0.218
2006 Yaksh TL, Luo ZD. Anatomy of the Pain Processing System Pain Management. 1: 11-20. DOI: 10.1016/B978-0-7216-0334-6.50006-6  0.218
1985 Hammond DL, Tyce GM, Yaksh TL. Efflux of 5‐hydroxytryptamine and noradrenaline into spinal cord superfusates during stimulation of the rat medulla The Journal of Physiology. 359: 151-162. PMID 2582112 DOI: 10.1113/Jphysiol.1985.Sp015579  0.217
1986 Furui T, Harty GJ, Yaksh TL. Studies on the effects of opioid, noradrenergic and serotonergic antagonists on the antinociceptive effects of electroconvulsive shock. Brain Research. 367: 162-8. PMID 2870768 DOI: 10.1016/0006-8993(86)91589-1  0.217
1997 Kakinohana M, Marsala M, Jun J, Yaksh T. A647 INTRATHECAL MORPHINE TRIGGERS TRANSIENT SPASTIC PARAPLEGIA AFTER NON-INJURIOUS INTERVAL OF SPINAL ISCHEMIA IN RAT Anesthesiology. 87: 647A. DOI: 10.1097/00000542-199709001-00647  0.217
2006 Rossi S, Yaksh T, Bentley H, van den Brande G, Grant I, Ellis R. Characterization of interference with 6 commercial delta9-tetrahydrocannabinol immunoassays by efavirenz (glucuronide) in urine. Clinical Chemistry. 52: 896-7. PMID 16638958 DOI: 10.1373/Clinchem.2006.067058  0.217
1997 Yaksh TL. Pain after injury: some basic mechanisms. The Journal of the Florida Medical Association. 84: 16-9. PMID 9037993  0.216
2012 Cohen SP, White RL, Kurihara C, Larkin TM, Chang A, Griffith SR, Gilligan C, Larkin R, Morlando B, Pasquina PF, Yaksh TL, Nguyen C. Epidural steroids, etanercept, or saline in subacute sciatica: a multicenter, randomized trial. Annals of Internal Medicine. 156: 551-9. PMID 22508732 DOI: 10.7326/0003-4819-156-8-201204170-00002  0.215
1993 Yamamoto T, Yaksh TL. Effects of colchicine applied to the peripheral nerve on the thermal hyperalgesia evoked with chronic nerve constriction Pain. 55: 227-233. PMID 7508592 DOI: 10.1016/0304-3959(93)90151-E  0.214
2009 Ilfeld BM, Yaksh TL. The end of postoperative pain--a fast-approaching possibility? And, if so, will we be ready? Regional Anesthesia and Pain Medicine. 34: 85-7. PMID 19282704 DOI: 10.1097/AAP.0b013e3181962547  0.213
1992 al-Rodhan NR, Richelson E, Gilbert JA, McCormick DJ, Kanba KS, Pfenning MA, Nelson A, Larson EW, Yaksh TL. Structure-antinociceptive activity of neurotensin and some novel analogues in the periaqueductal gray region of the brainstem. Brain Research. 557: 227-35. PMID 1660754 DOI: 10.1016/0006-8993(91)90139-M  0.213
1992 Yamamoto T, Yaksh TL. Studies on the spinal interaction of morphine and the NMDA antagonist MK-801 on the hyperesthesia observed in a rat model of sciatic mononeuropathy Neuroscience Letters. 135: 67-70. PMID 1311824 DOI: 10.1016/0304-3940(92)90137-V  0.213
1991 Yamamoto T, Yaksh T. Spinal and systemic antinociceptive actions of CP96345, a novel non-peptidic substance P antagonist, in the rat Anesthesiology. 75: A593-A593. DOI: 10.1097/00000542-199109001-00592  0.213
1997 Marsala M, Galik J, Ishikawa T, Yaksh TL. Technique of selective spinal cord cooling in rat: methodology and application. Journal of Neuroscience Methods. 74: 97-106. PMID 9210579  0.212
2001 Nozaki-Taguchi N, Chaplan SR, Higuera ES, Ajakwe RC, Yaksh TL. Vincristine-induced allodynia in the rat. Pain. 93: 69-76. PMID 11406340 DOI: 10.1016/S0304-3959(01)00294-9  0.212
2011 Walker SM, Grafe M, Yaksh TL. Sublethal spinal ketamine produces neuronal apoptosis in rat pups Anesthesiology. 114: 719-721. DOI: 10.1097/Aln.0B013E31820A86B3  0.212
1986 Yaksh TL, Noueihed RY, Durant PA. Studies of the pharmacology and pathology of intrathecally administered 4-anilinopiperidine analogues and morphine in the rat and cat. Anesthesiology. 64: 54-66. PMID 2867722 DOI: 10.1097/00000542-198601000-00009  0.212
1968 Platt JJ, Yaksh T, James WT. Response to environmental stimulus change in young opossums. Perceptual and Motor Skills. 26: 43-6. PMID 5642546 DOI: 10.2466/pms.1968.26.1.43  0.212
2023 Hunt MA, Hunt SAC, Edinger K, Steinauer J, Yaksh TL. Refinement of Intrathecal catheter design to enhance neuraxial distribution. Journal of Neuroscience Methods. 110006. PMID 37967672 DOI: 10.1016/j.jneumeth.2023.110006  0.211
2004 Khan IM, Wennerholm M, Singletary E, Polston K, Zhang L, Deerinck T, Yaksh TL, Taylor P. Ablation of primary afferent terminals reduces nicotinic receptor expression and the nociceptive responses to nicotinic agonists in the spinal cord. Journal of Neurocytology. 33: 543-56. PMID 15906161 DOI: 10.1007/S11068-004-0516-6  0.211
2010 Yaksh TL. The Pain State Arising From the Laminitic Horse: Insights Into Future Analgesic Therapies Journal of Equine Veterinary Science. 30: 79-82. DOI: 10.1016/j.jevs.2010.01.046  0.21
1994 Yaksh TL, Rathbun M, Jage J, Mirzai T, Grafe M, Hiles RA. Pharmacology and toxicology of chronically infused epidural clonidine.HCl in dogs. Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology. 23: 319-35. PMID 7835532 DOI: 10.1006/Faat.1994.1112  0.21
2016 Shubayev VI, Strongin AY, Yaksh TL. Role of myelin auto-antigens in pain: a female connection. Neural Regeneration Research. 11: 890-1. PMID 27482203 DOI: 10.4103/1673-5374.184452  0.21
1982 LoPachin RM, Rudy TA, Yaksh TL. An improved method for chronic catheterization of the rat spinal subarachnoid space. Physiology & Behavior. 27: 559-61. PMID 7335798 DOI: 10.1016/0031-9384(81)90350-4  0.21
2011 Yaksh TL. Pain: a sufferer's view Nature Medicine. 17: 773-773. DOI: 10.1038/nm0711-773  0.209
1994 Malmberg AB, Yaksh TL. Antinociception produced by spinal delivery of the S and R enantiomers of flurbiprofen in the formalin test European Journal of Pharmacology. 256: 205-209. PMID 8050472 DOI: 10.1016/0014-2999(94)90247-X  0.209
1992 Malmberg AB, Yaksh TL. HYPERALGESIA INDUCED BY SPINAL NMDA RECEPTORS IS REDUCED BY INTRATHECAL NMDA ANTAGONISTS AND NSAIDs Anesthesiology. 77: A703. DOI: 10.1097/00000542-199209001-00703  0.209
1995 Yaksh TL, Chaplan SR, Malmberg AB. Future directions in the pharmacological management of hyperalgesic and allodynic pain states: the NMDA receptor. Nida Research Monograph. 147: 84-103. PMID 8742782  0.207
1998 Khan IM, Buerkle H, Taylor P, Yaksh TL. Nociceptive and antinociceptive responses to intrathecally administered nicotinic agonists. Neuropharmacology. 37: 1515-25. PMID 9886674 DOI: 10.1016/S0028-3908(98)00143-9  0.207
2013 Yaksh TL. A Review of Pain-Processing Pharmacology Practical Management of Pain: Fifth Edition. 99-112. DOI: 10.1016/B978-0-323-08340-9.00009-8  0.207
1988 Gaumann DM, Yaksh TL. Intrathecal somatostatin in rats. Antinociception only in the presence of toxic effects Anesthesiology. 68: 733-742. PMID 2897175  0.206
1996 Buerkle H, Yaksh TL. Comparison of the spinal actions of the mu-opioid remifentanil with alfentanil and morphine in the rat. Anesthesiology. 84: 94-102. PMID 8572360 DOI: 10.1097/00000542-199601000-00012  0.206
2022 De Andres J, Hayek S, Perruchoud C, Lawrence MM, Reina MA, De Andres-Serrano C, Rubio-Haro R, Hunt M, Yaksh TL. Intrathecal Drug Delivery: Advances and Applications in the Management of Chronic Pain Patient. Frontiers in Pain Research (Lausanne, Switzerland). 3: 900566. PMID 35782225 DOI: 10.3389/fpain.2022.900566  0.205
1997 Sharp B, Yaksh T. Pain killers of the immune system. Nature Medicine. 3: 831-2. PMID 9256267 DOI: 10.1038/nm0897-831  0.204
2000 Yaksh TL, Provencher JC, Rathbun ML, Myers RR, Powell H, Richter P, Kohn FR. Safety assessment of encapsulated morphine delivered epidurally in a sustained-release multivesicular liposome preparation in dogs. Drug Delivery. 7: 27-36. PMID 10895417 DOI: 10.1080/107175400266768  0.204
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