Paul J. Shughrue - Publications

Affiliations: 
Merck Pharmaceuticals, Lincoln, NJ, United States 
Area:
estrogen

71 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Prokai L, Nguyen V, Szarka S, Garg P, Sabnis G, Bimonte-Nelson HA, McLaughlin KJ, Talboom JS, Conrad CD, Shughrue PJ, Gould TD, Brodie A, Merchenthaler I, Koulen P, Prokai-Tatrai K. The prodrug DHED selectively delivers 17β-estradiol to the brain for treating estrogen-responsive disorders Science Translational Medicine. 7. DOI: 10.1126/scitranslmed.aab1290  1
2014 Savage MJ, Kalinina J, Wolfe A, Tugusheva K, Korn R, Cash-Mason T, Maxwell JW, Hatcher NG, Haugabook SJ, Wu G, Howell BJ, Renger JJ, Shughrue PJ, McCampbell A. A sensitive aβ oligomer assay discriminates Alzheimer's and aged control cerebrospinal fluid. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 2884-97. PMID 24553930 DOI: 10.1523/JNEUROSCI.1675-13.2014  1
2010 Yu Y, Jin H, Holder D, Ozer JS, Villarreal S, Shughrue P, Shi S, Figueroa DJ, Clouse H, Su M, Muniappa N, Troth SP, Bailey W, Seng J, Aslamkhan AG, et al. Urinary biomarkers trefoil factor 3 and albumin enable early detection of kidney tubular injury. Nature Biotechnology. 28: 470-7. PMID 20458317 DOI: 10.1038/nbt.1624  1
2010 Zhao WQ, Santini F, Breese R, Ross D, Zhang XD, Stone DJ, Ferrer M, Townsend M, Wolfe AL, Seager MA, Kinney GG, Shughrue PJ, Ray WJ. Inhibition of calcineurin-mediated endocytosis and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors prevents amyloid beta oligomer-induced synaptic disruption. The Journal of Biological Chemistry. 285: 7619-32. PMID 20032460 DOI: 10.1074/jbc.M109.057182  1
2010 Gaspar RC, Villarreal SA, Bowles N, Hepler RW, Joyce JG, Shughrue PJ. Oligomers of beta-amyloid are sequestered into and seed new plaques in the brains of an AD mouse model. Experimental Neurology. 223: 394-400. PMID 19744481 DOI: 10.1016/j.expneurol.2009.09.001  1
2010 Shughrue PJ, Acton PJ, Breese RS, Zhao WQ, Chen-Dodson E, Hepler RW, Wolfe AL, Matthews M, Heidecker GJ, Joyce JG, Villarreal SA, Kinney GG. Anti-ADDL antibodies differentially block oligomer binding to hippocampal neurons. Neurobiology of Aging. 31: 189-202. PMID 18486276 DOI: 10.1016/j.neurobiolaging.2008.04.003  1
2010 Villarreal SA, Wu Z, Gray A, Shughrue PJ. Evaluation of amyloid plaque in an Alzheimer's disease mouse model with the use of stereological versus aperio analysis Journal of Histotechnology. 33: 161-164.  1
2009 Ma L, Seager MA, Seager M, Wittmann M, Jacobson M, Bickel D, Burno M, Jones K, Graufelds VK, Xu G, Pearson M, McCampbell A, Gaspar R, Shughrue P, Danziger A, et al. Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation. Proceedings of the National Academy of Sciences of the United States of America. 106: 15950-5. PMID 19717450 DOI: 10.1073/pnas.0900903106  1
2009 Ma L, Seager MA, Wittmann M, Jacobson M, Bickel D, Burno M, Jones K, Graufelds VK, Xu G, Pearson M, McCampbell A, Gaspar R, Shughrue P, Danziger A, Regan C, et al. Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation (Proceedings of the National Academy of Sciences of the United States of America (2009) 106, (15950-15955) DOI: 10.1073/pnas.0900903106) Proceedings of the National Academy of Sciences of the United States of America. 106: 18040. DOI: 10.1073/pnas.0910597106  1
2008 De Felice FG, Wu D, Lambert MP, Fernandez SJ, Velasco PT, Lacor PN, Bigio EH, Jerecic J, Acton PJ, Shughrue PJ, Chen-Dodson E, Kinney GG, Klein WL. Alzheimer's disease-type neuronal tau hyperphosphorylation induced by A beta oligomers. Neurobiology of Aging. 29: 1334-47. PMID 17403556 DOI: 10.1016/j.neurobiolaging.2007.02.029  1
2006 Hepler RW, Grimm KM, Nahas DD, Breese R, Dodson EC, Acton P, Keller PM, Yeager M, Wang H, Shughrue P, Kinney G, Joyce JG. Solution state characterization of amyloid beta-derived diffusible ligands. Biochemistry. 45: 15157-67. PMID 17176037 DOI: 10.1021/bi061850f  1
2006 Majercak J, Ray WJ, Espeseth A, Simon A, Shi XP, Wolffe C, Getty K, Marine S, Stec E, Ferrer M, Strulovici B, Bartz S, Gates A, Xu M, Huang Q, ... ... Shughrue P, et al. LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 103: 17967-72. PMID 17098871 DOI: 10.1073/pnas.0605461103  1
2006 West BD, Shughrue PJ, Vanko AE, Ransom RW, Kinney GG. Amphetamine-induced locomotor activity is reduced in mice following MPTP treatment but not following selegiline/MPTP treatment. Pharmacology, Biochemistry, and Behavior. 84: 158-61. PMID 16757017 DOI: 10.1016/j.pbb.2006.04.022  1
2006 Dubal DB, Rau SW, Shughrue PJ, Zhu H, Yu J, Cashion AB, Suzuki S, Gerhold LM, Bottner MB, Dubal SB, Merchanthaler I, Kindy MS, Wise PM. Differential modulation of estrogen receptors (ERs) in ischemic brain injury: a role for ERalpha in estradiol-mediated protection against delayed cell death. Endocrinology. 147: 3076-84. PMID 16527848 DOI: 10.1210/en.2005-1177  1
2005 Merchenthaler I, Shughrue PJ. Neuroprotection by estrogen in animal models of ischemia and Parkinson's disease Drug Development Research. 66: 172-181. DOI: 10.1002/ddr.20056  1
2004 Shughrue PJ. Estrogen attenuates the MPTP-induced loss of dopamine neurons from the mouse SNc despite a lack of estrogen receptors (ERalpha and ERbeta). Experimental Neurology. 190: 468-77. PMID 15530885 DOI: 10.1016/j.expneurol.2004.08.009  1
2004 Austin CP, Ky B, Ma L, Morris JA, Shughrue PJ. Expression of Disrupted-In-Schizophrenia-1, a schizophrenia-associated gene, is prominent in the mouse hippocampus throughout brain development. Neuroscience. 124: 3-10. PMID 14960334 DOI: 10.1016/j.neuroscience.2003.11.010  1
2003 Merchenthaler I, Dellovade TL, Shughrue PJ. Neuroprotection by estrogen in animal models of global and focal ischemia. Annals of the New York Academy of Sciences. 1007: 89-100. PMID 14993043 DOI: 10.1196/annals.1286.009  1
2003 Shughrue PJ, Ky B, Austin CP. Localization of B1 bradykinin receptor mRNA in the primate brain and spinal cord: an in situ hybridization study. The Journal of Comparative Neurology. 465: 372-84. PMID 12966562 DOI: 10.1002/cne.10846  1
2003 Austin CP, Ma L, Ky B, Morris JA, Shughrue PJ. DISC1 (Disrupted in Schizophrenia-1) is expressed in limbic regions of the primate brain. Neuroreport. 14: 951-4. PMID 12802181 DOI: 10.1097/01.wnr.0000074342.81633.63  1
2003 Flores CA, Shughrue P, Petersen SL, Mokha SS. Sex-related differences in the distribution of opioid receptor-like 1 receptor mRNA and colocalization with estrogen receptor mRNA in neurons of the spinal trigeminal nucleus caudalis in the rat Neuroscience. 118: 769-778. PMID 12710984 DOI: 10.1016/S0306-4522(02)01000-X  1
2003 Shughrue PJ, Merchenthaler I. Estrogen prevents the loss of CA1 hippocampal neurons in gerbils after ischemic injury. Neuroscience. 116: 851-61. PMID 12573724 DOI: 10.1016/S0306-4522(02)00790-X  1
2002 Ma L, Liu Y, Ky B, Shughrue PJ, Austin CP, Morris JA. Cloning and characterization of Disc1, the mouse ortholog of DISC1 (Disrupted-in-Schizophrenia 1). Genomics. 80: 662-72. PMID 12504857 DOI: 10.1006/geno.2002.7012  1
2002 Shughrue PJ, Dellovade TL, Merchenthaler I. Estrogen modulates oxytocin gene expression in regions of the rat supraoptic and paraventricular nuclei that contain estrogen receptor-beta. Progress in Brain Research. 139: 15-29. PMID 12436923 DOI: 10.1016/S0079-6123(02)39004-6  1
2002 Ky B, Shughrue PJ. Methods to enhance signal using isotopic in situ hybridization. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 50: 1031-7. PMID 12133906  1
2002 Shughrue PJ, Askew GR, Dellovade TL, Merchenthaler I. Estrogen-binding sites and their functional capacity in estrogen receptor double knockout mouse brain. Endocrinology. 143: 1643-50. PMID 11956145 DOI: 10.1210/endo.143.5.8772  1
2002 Wilson ME, Rosewell KL, Kashon ML, Shughrue PJ, Merchenthaler I, Wise PM. Age differentially influences estrogen receptor-alpha (ERalpha) and estrogen receptor-beta (ERbeta) gene expression in specific regions of the rat brain. Mechanisms of Ageing and Development. 123: 593-601. PMID 11850023 DOI: 10.1016/S0047-6374(01)00406-7  1
2001 Hrabovszky E, Steinhauser A, Barabás K, Shughrue PJ, Petersen SL, Merchenthaler I, Liposits Z. Estrogen receptor-beta immunoreactivity in luteinizing hormone-releasing hormone neurons of the rat brain. Endocrinology. 142: 3261-4. PMID 11416051 DOI: 10.1210/endo.142.7.8176  1
2001 Fan H, Favero M, Vogel MW. Elimination of Bax expression in mice increases cerebellar purkinje cell numbers but not the number of granule cells. The Journal of Comparative Neurology. 436: 82-91. PMID 11413548 DOI: 10.1002/cne.1055  1
2001 Papka RE, Storey-Workley M, Shughrue PJ, Merchenthaler I, Collins JJ, Usip S, Saunders PT, Shupnik M. Estrogen receptor-alpha and beta- immunoreactivity and mRNA in neurons of sensory and autonomic ganglia and spinal cord. Cell and Tissue Research. 304: 193-214. PMID 11396714 DOI: 10.1007/s004410100363  1
2001 Dubal DB, Zhu H, Yu J, Rau SW, Shughrue PJ, Merchenthaler I, Kindy MS, Wise PM. Estrogen receptor alpha, not beta, is a critical link in estradiol-mediated protection against brain injury. Proceedings of the National Academy of Sciences of the United States of America. 98: 1952-7. PMID 11172057 DOI: 10.1073/pnas.041483198  1
2000 Shughrue PJ, Merchenthaler I. Evidence for novel estrogen binding sites in the rat hippocampus. Neuroscience. 99: 605-12. PMID 10974424 DOI: 10.1016/S0306-4522(00)00242-6  1
2000 Hrabovszky E, Shughrue PJ, Merchenthaler I, Hajszán T, Carpenter CD, Liposits Z, Petersen SL. Detection of estrogen receptor-beta messenger ribonucleic acid and 125I-estrogen binding sites in luteinizing hormone-releasing hormone neurons of the rat brain. Endocrinology. 141: 3506-9. PMID 10965924 DOI: 10.1210/endo.141.9.7788  1
2000 Shughrue PJ, Scrimo PJ, Merchenthaler I. Estrogen binding and estrogen receptor characterization (ERalpha and ERbeta) in the cholinergic neurons of the rat basal forebrain. Neuroscience. 96: 41-9. PMID 10683408 DOI: 10.1016/S0306-4522(99)00520-5  1
2000 Shughrue PJ, Merchenthaler I. Estrogen is more than just a "sex hormone": novel sites for estrogen action in the hippocampus and cerebral cortex. Frontiers in Neuroendocrinology. 21: 95-101. PMID 10662537 DOI: 10.1006/frne.1999.0190  1
1999 Horvath TL, Diano S, Sakamoto H, Shughrue PJ, Merchenthaler I. Estrogen receptor beta and progesterone receptor mRNA in the intergeniculate leaflet of the female rat. Brain Research. 844: 196-200. PMID 10536277 DOI: 10.1016/S0006-8993(99)01759-X  1
1999 Fekete CS, Strutton PH, Cagampang FR, Hrabovszky E, Kalló I, Shughrue PJ, Dobó E, Mihály E, Baranyi L, Okada H, Panula P, Merchenthaler I, Coen CW, Liposits ZS. Estrogen receptor immunoreactivity is present in the majority of central histaminergic neurons: evidence for a new neuroendocrine pathway associated with luteinizing hormone-releasing hormone-synthesizing neurons in rats and humans. Endocrinology. 140: 4335-41. PMID 10465307 DOI: 10.1210/endo.140.9.6968  1
1999 Dubal DB, Shughrue PJ, Wilson ME, Merchenthaler I, Wise PM. Estradiol modulates bcl-2 in cerebral ischemia: a potential role for estrogen receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 6385-93. PMID 10414967  1
1999 Shughrue PJ, Lane MV, Merchenthaler I. Biologically active estrogen receptor-beta: evidence from in vivo autoradiographic studies with estrogen receptor alpha-knockout mice. Endocrinology. 140: 2613-20. PMID 10342848 DOI: 10.1210/endo.140.6.6876  1
1999 Thomas A, Shughrue PJ, Merchenthaler I, Amico JA. The effects of progesterone on oxytocin mRNA levels in the paraventricular nucleus of the female rat can be altered by the administration of diazepam or RU486. Journal of Neuroendocrinology. 11: 137-44. PMID 10048469 DOI: 10.1046/j.1365-2826.1999.00294.x  1
1999 Merchenthaler I, Lane M, Shughrue P. Distribution of pre-pro-glucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system Journal of Comparative Neurology. 403: 261-280. PMID 9886047 DOI: 10.1002/(SICI)1096-9861(19990111)403:2<261::AID-CNE8>3.0.CO;2-5  1
1998 Shughrue PJ, Scrimo PJ, Merchenthaler I. Evidence for the colocalization of estrogen receptor-beta mRNA and estrogen receptor-alpha immunoreactivity in neurons of the rat forebrain. Endocrinology. 139: 5267-70. PMID 9832469 DOI: 10.1210/endo.139.12.6525  1
1998 Shughrue PJ, Lane MV, Scrimo PJ, Merchenthaler I. Comparative distribution of estrogen receptor-alpha (ER-alpha) and beta (ER-beta) mRNA in the rat pituitary, gonad, and reproductive tract. Steroids. 63: 498-504. PMID 9800279 DOI: 10.1016/S0039-128X(98)00054-3  1
1998 Kuiper GG, Shughrue PJ, Merchenthaler I, Gustafsson JA. The estrogen receptor beta subtype: a novel mediator of estrogen action in neuroendocrine systems. Frontiers in Neuroendocrinology. 19: 253-86. PMID 9799586 DOI: 10.1006/frne.1998.0170  1
1998 Shughrue PJ. Estrogen action in the estrogen receptor alpha-knockout mouse: is this due to ER-beta? Molecular Psychiatry. 3: 299-302. PMID 9702737  1
1998 Hrabovszky E, Kalló I, Hajszán T, Shughrue PJ, Merchenthaler I, Liposits Z. Expression of estrogen receptor-beta messenger ribonucleic acid in oxytocin and vasopressin neurons of the rat supraoptic and paraventricular nuclei. Endocrinology. 139: 2600-4. PMID 9564876 DOI: 10.1210/endo.139.5.6024  1
1998 Fitzpatrick SL, Sindoni DM, Shughrue PJ, Lane MV, Merchenthaler IJ, Frail DE. Expression of growth differentiation factor-9 messenger ribonucleic acid in ovarian and nonovarian rodent and human tissues. Endocrinology. 139: 2571-8. PMID 9564873 DOI: 10.1210/endo.139.5.6014  1
1997 Shughrue P, Scrimo P, Lane M, Askew R, Merchenthaler I. The distribution of estrogen receptor-β mRNA in forebrain regions of the estrogen receptor-α knockout mouse Endocrinology. 138: 5649-5652. PMID 9389555  1
1997 Shughrue PJ, Lane MV, Merchenthaler I. Regulation of progesterone receptor messenger ribonucleic acid in the rat medial preoptic nucleus by estrogenic and antiestrogenic compounds: an in situ hybridization study. Endocrinology. 138: 5476-84. PMID 9389534 DOI: 10.1210/endo.138.12.5595  1
1997 Shughrue PJ, Lane MV, Merchenthaler I. Comparative distribution of estrogen receptor-alpha and -beta mRNA in the rat central nervous system. The Journal of Comparative Neurology. 388: 507-25. PMID 9388012 DOI: 10.1002/(SICI)1096-9861(19971201)388:4<507::AID-CNE1>3.0.CO;2-6  1
1997 Shughrue PJ, Lubahn DB, Negro-Vilar A, Korach KS, Merchenthaler I. Responses in the brain of estrogen receptor alpha-disrupted mice. Proceedings of the National Academy of Sciences of the United States of America. 94: 11008-12. PMID 9380750 DOI: 10.1073/pnas.94.20.11008  1
1997 Merchenthaler I, Maderdrut JL, Cianchetta P, Shughrue P, Bronstein D. In situ hybridization histochemical localization of prodynorphin messenger RNA in the central nervous system of the rat Journal of Comparative Neurology. 384: 211-232. PMID 9215719 DOI: 10.1002/(SICI)1096-9861(19970728)384:2<211::AID-CNE4>3.0.CO;2-4  1
1996 Shughrue PJ, Komm B, Merchenthaler I. The distribution of estrogen receptor-beta mRNA in the rat hypothalamus. Steroids. 61: 678-81. PMID 8987135 DOI: 10.1016/S0039-128X(96)00222-X  1
1996 Shughrue PJ, Lane MV, Merchenthaler I. Glucagon-like peptide-1 receptor (GLP1-R) mRNA in the rat hypothalamus. Endocrinology. 137: 5159-62. PMID 8895391 DOI: 10.1210/endo.137.11.8895391  1
1996 Shughrue PJ, Lane MV, Merchenthaler I. In situ hybridization analysis of the distribution of neurokinin-3 mRNA in the rat central nervous system. The Journal of Comparative Neurology. 372: 395-414. PMID 8873868 DOI: 10.1002/(SICI)1096-9861(19960826)372:3<395::AID-CNE5>3.0.CO;2-Y  1
1995 Zhou Y, Shughrue PJ, Dorsa DM. Estrogen receptor protein is differentially regulated in the preoptic area of the brain and in the uterus during the rat estrous cycle. Neuroendocrinology. 61: 276-83. PMID 7898632  1
1994 Shughrue PJ, Dorsa DM. The ontogeny of GAP-43 (neuromodulin) mRNA in postnatal rat brain: evidence for a sex dimorphism. The Journal of Comparative Neurology. 340: 174-84. PMID 8201017 DOI: 10.1002/cne.903400204  1
1994 Shughrue PJ, Dorsa DM. Estrogen and androgen differentially modulate the growth-associated protein GAP-43 (neuromodulin) messenger ribonucleic acid in postnatal rat brain. Endocrinology. 134: 1321-8. PMID 8119173 DOI: 10.1210/endo.134.3.8119173  1
1993 Shughrue PJ, Dorsa DM. Gonadal steroids modulate the growth-associated protein GAP-43 (neuromodulin) mRNA in postnatal rat brain. Brain Research. Developmental Brain Research. 73: 123-32. PMID 8513551 DOI: 10.1016/0165-3806(93)90054-E  1
1993 Shughrue PJ, Dorsa DM. Estrogen modulates the growth-associated protein GAP-43 (Neuromodulin) mRNA in the rat preoptic area and basal hypothalamus. Neuroendocrinology. 57: 439-47. PMID 8321416 DOI: 10.1159/000126390  1
1992 Shughrue PJ, Bushnell CD, Dorsa DM. Estrogen receptor messenger ribonucleic acid in female rat brain during the estrous cycle: a comparison with ovariectomized females and intact males. Endocrinology. 131: 381-8. PMID 1612018 DOI: 10.1210/endo.131.1.1612018  1
1992 Shughrue PJ, Sar M, Stumpf WE. Progestin target cell distribution in forebrain and midbrain regions of the 8-day postnatal mouse brain. Endocrinology. 130: 3650-9. PMID 1597162 DOI: 10.1210/endo.130.6.1597162  1
1992 Shughrue PJ, Dorsa DM. The removal of emulsion from section-mounted in situ hybridization slides after accidental exposure to light. Biotechniques. 13: 498-9. PMID 1476712  1
1991 Shughrue PJ, Stumpf WE, Elger W, Schulze PE, Sar M. Progestin receptor cells in the 8-day-old male and female mouse cerebral cortex: autoradiographic evidence for a sexual dimorphism in target cell number. Endocrinology. 128: 87-95. PMID 1986948 DOI: 10.1210/endo-128-1-87  1
1991 Sibug RM, Stumpf WE, Shughrue PJ, Hochberg RB, Drews U. Distribution of estrogen target sites in the 2-day-old mouse forebrain and pituitary gland during the 'critical period' of sexual differentiation. Brain Research. Developmental Brain Research. 61: 11-22. PMID 1914151 DOI: 10.1016/0165-3806(91)90109-V  1
1991 Shughrue PJ, Stumpf WE, Elger W, Schulze PE, Sar M. Progestin receptor cells in mouse cerebral cortex during early postnatal development: a comparison with preoptic area and central hypothalamus using autoradiography with [125I]progestin. Brain Research. Developmental Brain Research. 59: 143-55. PMID 1914138 DOI: 10.1016/0165-3806(91)90094-Y  1
1990 Shughrue PJ, Stumpf WE, MacLusky NJ, Zielinski JE, Hochberg RB. Developmental changes in estrogen receptors in mouse cerebral cortex between birth and postweaning: studied by autoradiography with 11 beta-methoxy-16 alpha-[125I]iodoestradiol. Endocrinology. 126: 1112-24. PMID 2298154 DOI: 10.1210/endo-126-2-1112  1
1990 Murakami R, Shughrue PJ, Stumpf WE, Elger W, Schulze PE. Distribution of progestin-binding cells in estrogen-treated and untreated neonatal mouse uterus and oviduct: autoradiographic study with [125I]progestin. Histochemistry. 94: 155-9. PMID 2162811 DOI: 10.1007/BF02440182  1
1989 Shughrue PJ, Stumpf WE, Sar M, Elger W, Schulze PE. Progestin receptors in brain and pituitary of 20-day-old fetal mice: an autoradiographic study using [125I]progestin. Endocrinology. 124: 333-8. PMID 2909372 DOI: 10.1210/endo-124-1-333  1
1988 Shughrue PJ, Stumpf WE, Sar M. The distribution of progesterone receptor in the 20-day-old fetal mouse: an autoradiographic study with [125I]progestin. Endocrinology. 123: 2382-9. PMID 3168927 DOI: 10.1210/endo-123-5-2382  1
1987 Keefer DA, Dordai N, Mallonga R, Ziegler K, Shughrue P, Ramirez P. Dihydrotestosterone induces a sexual dimorphism in estrogen uptake by specific anterior pituitary cell types in vivo Cell and Tissue Research. 249: 477-479. PMID 3621311 DOI: 10.1007/BF00215534  1
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