Alicia R. Timme-Laragy, Ph.D. - Publications

Affiliations: 
2007 Duke University, Durham, NC 
Area:
Toxicology, Environmental Sciences

40 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Leonard ER, Marques ES, Roy MA, Conlin SM, Ranjan R, Timme-Laragy AR. Dietary exposure to the food preservative tert-Butylhydroquinone (tBHQ) impairs zebrafish (Danio rerio) survival, growth, organ development, and gene expression in Nrf2a-dependent and independent ways. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. 113788. PMID 37075880 DOI: 10.1016/j.fct.2023.113788  0.304
2022 Marques ES, Severance EG, Min B, Arsenault P, Conlin SM, Timme-Laragy AR. Developmental impacts of Nrf2 activation by dimethyl fumarate (DMF) in the developing zebrafish (Danio rerio) embryo. Free Radical Biology & Medicine. 194: 284-297. PMID 36528121 DOI: 10.1016/j.freeradbiomed.2022.12.013  0.402
2022 Roy MA, Gridley CK, Li S, Park Y, Timme-Laragy AR. Nrf2a dependent and independent effects of early life exposure to 3,3'-dichlorobiphenyl (PCB-11) in zebrafish (Danio rerio). Aquatic Toxicology (Amsterdam, Netherlands). 249: 106219. PMID 35700651 DOI: 10.1016/j.aquatox.2022.106219  0.429
2021 Annunziato KM, Marin M, Liang W, Conlin SM, Qi W, Doherty J, Lee J, Clark JM, Park Y, Timme-Laragy AR. The Nrf2a pathway impacts zebrafish offspring development with maternal preconception exposure to perfluorobutanesulfonic acid. Chemosphere. 287: 132121. PMID 34509758 DOI: 10.1016/j.chemosphere.2021.132121  0.338
2021 Venezia O, Islam S, Cho C, Timme-Laragy AR, Sant KE. Modulation of PPAR signaling disrupts pancreas development in the zebrafish, Danio rerio. Toxicology and Applied Pharmacology. 426: 115653. PMID 34302850 DOI: 10.1016/j.taap.2021.115653  0.437
2021 Kim JH, Barbagallo B, Annunziato K, Farias-Pereira R, Doherty JJ, Lee J, Zina J, Tindal C, McVey C, Aresco R, Johnstone M, Sant KE, Timme-Laragy A, Park Y, Clark JM. Maternal Preconception PFOS Exposure of Drosophila melanogaster Alters Reproductive Capacity, Development, Morphology and Nutrient Regulation. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. 112153. PMID 33774094 DOI: 10.1016/j.fct.2021.112153  0.378
2021 Wauchope S, Roy MA, Irvine W, Morrison I, Brantley E, Gossell-Williams M, Timme-Laragy AR, Delgoda R. Dibenzyl trisulfide binds to and competitively inhibits the cytochrome P450 1A1 active site without impacting the expression of aryl hydrocarbon receptor. Toxicology and Applied Pharmacology. 115502. PMID 33774063 DOI: 10.1016/j.taap.2021.115502  0.372
2021 Sant KE, Annunziato K, Conlin S, Teicher G, Chen P, Venezia O, Downes GB, Park Y, Timme-Laragy AR. Developmental exposures to perfluorooctanesulfonic acid (PFOS) impact embryonic nutrition, pancreatic morphology, and adiposity in the zebrafish, Danio rerio. Environmental Pollution (Barking, Essex : 1987). 275: 116644. PMID 33581636 DOI: 10.1016/j.envpol.2021.116644  0.373
2021 Rastogi A, Timme-Laragy AR. Using Monochlorobimane to Visualize Glutathione Utilization in the Developing Zebrafish (Danio rerio) Embryo. Current Protocols. 1: e124. PMID 33555621 DOI: 10.1002/cpz1.24  0.335
2020 Rastogi A, Severance EG, Jacobs HM, Conlin SM, Islam ST, Timme-Laragy AR. Modulating glutathione thiol status alters pancreatic β-cell morphogenesis in the developing zebrafish (Danio rerio) embryo. Redox Biology. 38: 101788. PMID 33321464 DOI: 10.1016/j.redox.2020.101788  0.36
2020 Roy MA, Duche PR, Timme-Laragy AR. The sulfate metabolite of 3,3'-dichlorobiphenyl (PCB-11) impairs Cyp1a activity and increases hepatic neutral lipids in zebrafish larvae (Danio rerio). Chemosphere. 260: 127609. PMID 32693259 DOI: 10.1016/j.chemosphere.2020.127609  0.385
2020 Sant KE, Moreau HM, Williams LM, Jacobs HM, Bowsher AM, Boisvert JD, Smolowitz RM, Pantazis J, Annunziato K, Nguyen M, Timme-Laragy A. Embryonic exposures to mono-2-ethylhexyl phthalate induce larval steatosis in zebrafish independent of Nrf2a signaling. Journal of Developmental Origins of Health and Disease. 1-9. PMID 32063256 DOI: 10.1017/S2040174420000057  0.52
2019 Roy MA, Sant KE, Venezia OL, Shipman AB, McCormick SD, Saktrakulkla P, Hornbuckle KC, Timme-Laragy AR. The emerging contaminant 3,3'-dichlorobiphenyl (PCB-11) impedes Ahr activation and Cyp1a activity to modify embryotoxicity of Ahr ligands in the zebrafish embryo model (Danio rerio). Environmental Pollution (Barking, Essex : 1987). 254: 113027. PMID 31421573 DOI: 10.1016/J.Envpol.2019.113027  0.486
2018 Sant KE, Venezia OL, Sinno PP, Timme-Laragy AR. Perfluorobutanesulfonic acid disrupts pancreatic organogenesis and regulation of lipid metabolism in the zebrafish, Danio rerio. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 30239974 DOI: 10.1093/toxsci/kfy237  0.335
2018 Sant KE, Sinno PP, Jacobs HM, Timme-Laragy AR. Nrf2a modulates the embryonic antioxidant response to perfluorooctanesulfonic acid (PFOS) in the zebrafish, Danio rerio. Aquatic Toxicology (Amsterdam, Netherlands). 198: 92-102. PMID 29524743 DOI: 10.1016/j.aquatox.2018.02.010  0.492
2017 Jacobs HM, Sant KE, Basnet A, Williams LM, Moss JB, Timme-Laragy AR. Embryonic exposure to Mono(2-ethylhexyl) phthalate (MEHP) disrupts pancreatic organogenesis in zebrafish (Danio rerio). Chemosphere. 195: 498-507. PMID 29277029 DOI: 10.1016/J.Chemosphere.2017.12.094  0.47
2017 Timme-Laragy AR, Hahn ME, Hansen JM, Rastogi A, Roy MA. Redox stress and signaling during vertebrate embryonic development: regulation and responses. Seminars in Cell & Developmental Biology. PMID 28927759 DOI: 10.1016/j.semcdb.2017.09.019  0.304
2017 Sant KE, Hansen JM, Williams LM, Tran NL, Goldstone JV, Stegeman JJ, Hahn ME, Timme-Laragy A. The role of Nrf1 and Nrf2 in the regulation of glutathione and redox dynamics in the developing zebrafish embryo. Redox Biology. 13: 207-218. PMID 28582729 DOI: 10.1016/J.Redox.2017.05.023  0.408
2016 Sant KE, Jacobs HM, Xu J, Borofski KA, Moss LG, Moss JB, Timme-Laragy AR. Assessment of Toxicological Perturbations and Variants of Pancreatic Islet Development in the Zebrafish Model. Toxics. 4. PMID 28393070 DOI: 10.3390/toxics4030020  0.352
2016 Sant KE, Jacobs HM, Borofski KA, Moss JB, Timme-Laragy AR. Embryonic exposures to perfluorooctanesulfonic acid (PFOS) disrupt pancreatic organogenesis in the zebrafish, Danio rerio. Environmental Pollution (Barking, Essex : 1987). PMID 27810111 DOI: 10.1016/j.envpol.2016.10.057  0.34
2016 Wincent E, Kubota A, Timme-Laragy A, Jönsson ME, Hahn ME, Stegeman JJ. Biological effects of 6-formylindolo[3,2-b]carbazole (FICZ) in vivo are enhanced by loss of CYP1A function in an Ahr2-dependent manner. Biochemical Pharmacology. PMID 27112072 DOI: 10.1016/J.Bcp.2016.04.012  0.469
2015 Timme-Laragy AR, Sant KE, Rousseau ME, diIorio PJ. Deviant development of pancreatic beta cells from embryonic exposure to PCB-126 in zebrafish. Comparative Biochemistry and Physiology. Toxicology & Pharmacology : Cbp. 178: 25-32. PMID 26393762 DOI: 10.1016/j.cbpc.2015.08.012  0.375
2015 Rousseau ME, Sant KE, Borden LR, Franks DG, Hahn ME, Timme-Laragy AR. Regulation of Ahr signaling by Nrf2 during development: Effects of Nrf2a deficiency on PCB126 embryotoxicity in zebrafish (Danio rerio). Aquatic Toxicology (Amsterdam, Netherlands). 167: 157-71. PMID 26325326 DOI: 10.1016/j.aquatox.2015.08.002  0.479
2015 Hahn ME, Timme-Laragy AR, Karchner SI, Stegeman JJ. Nrf2 and Nrf2-related proteins in development and developmental toxicity: Insights from studies in zebrafish (Danio rerio). Free Radical Biology & Medicine. 88: 275-89. PMID 26130508 DOI: 10.1016/J.Freeradbiomed.2015.06.022  0.36
2014 Hahn ME, McArthur AG, Karchner SI, Franks DG, Jenny MJ, Timme-Laragy AR, Stegeman JJ, Woodin BR, Cipriano MJ, Linney E. The transcriptional response to oxidative stress during vertebrate development: effects of tert-butylhydroquinone and 2,3,7,8-tetrachlorodibenzo-p-dioxin. Plos One. 9: e113158. PMID 25402455 DOI: 10.1371/Journal.Pone.0113158  0.428
2013 Williams LM, Timme-Laragy AR, Goldstone JV, McArthur AG, Stegeman JJ, Smolowitz RM, Hahn ME. Developmental expression of the Nfe2-related factor (Nrf) transcription factor family in the zebrafish, Danio rerio. Plos One. 8: e79574. PMID 24298298 DOI: 10.1371/Journal.Pone.0079574  0.451
2013 Timme-Laragy AR, Goldstone JV, Imhoff BR, Stegeman JJ, Hahn ME, Hansen JM. Glutathione redox dynamics and expression of glutathione-related genes in the developing embryo. Free Radical Biology & Medicine. 65: 89-101. PMID 23770340 DOI: 10.1016/J.Freeradbiomed.2013.06.011  0.393
2013 Zhao B, Bohonowych JE, Timme-Laragy A, Jung D, Affatato AA, Rice RH, Di Giulio RT, Denison MS. Common commercial and consumer products contain activators of the aryl hydrocarbon (dioxin) receptor. Plos One. 8: e56860. PMID 23441220 DOI: 10.1371/Journal.Pone.0056860  0.633
2013 Harbeitner RC, Hahn ME, Timme-Laragy AR. Differential sensitivity to pro-oxidant exposure in two populations of killifish (Fundulus heteroclitus). Ecotoxicology (London, England). 22: 387-401. PMID 23329125 DOI: 10.1007/s10646-012-1033-x  0.494
2012 Jönsson ME, Kubota A, Timme-Laragy AR, Woodin B, Stegeman JJ. Ahr2-dependence of PCB126 effects on the swim bladder in relation to expression of CYP1 and cox-2 genes in developing zebrafish. Toxicology and Applied Pharmacology. 265: 166-74. PMID 23036320 DOI: 10.1016/J.Taap.2012.09.023  0.347
2012 Timme-Laragy AR, Karchner SI, Hahn ME. Gene knockdown by morpholino-modified oligonucleotides in the zebrafish (Danio rerio) model: applications for developmental toxicology. Methods in Molecular Biology (Clifton, N.J.). 889: 51-71. PMID 22669659 DOI: 10.1007/978-1-61779-867-2_5  0.348
2012 Timme-Laragy AR, Karchner SI, Franks DG, Jenny MJ, Harbeitner RC, Goldstone JV, McArthur AG, Hahn ME. Nrf2b, novel zebrafish paralog of oxidant-responsive transcription factor NF-E2-related factor 2 (NRF2). The Journal of Biological Chemistry. 287: 4609-27. PMID 22174413 DOI: 10.1074/jbc.M111.260125  0.428
2009 Timme-Laragy AR, Van Tiem LA, Linney EA, Di Giulio RT. Antioxidant responses and NRF2 in synergistic developmental toxicity of PAHs in zebrafish. Toxicological Sciences : An Official Journal of the Society of Toxicology. 109: 217-27. PMID 19233942 DOI: 10.1093/Toxsci/Kfp038  0.451
2008 Matson CW, Timme-Laragy AR, Di Giulio RT. Fluoranthene, but not benzo[a]pyrene, interacts with hypoxia resulting in pericardial effusion and lordosis in developing zebrafish. Chemosphere. 74: 149-54. PMID 18840388 DOI: 10.1016/J.Chemosphere.2008.08.016  0.548
2008 Timme-Laragy AR, Noyes PD, Buhler DR, Di Giulio RT. CYP1B1 knockdown does not alter synergistic developmental toxicity of polycyclic aromatic hydrocarbons in zebrafish (Danio rerio). Marine Environmental Research. 66: 85-7. PMID 18378296 DOI: 10.1016/J.Marenvres.2008.02.030  0.572
2008 Bohonowych JE, Zhao B, Timme-Laragy A, Jung D, Di Giulio RT, Denison MS. Newspapers and newspaper ink contain agonists for the ah receptor. Toxicological Sciences : An Official Journal of the Society of Toxicology. 102: 278-90. PMID 18203687 DOI: 10.1093/Toxsci/Kfn011  0.586
2007 Timme-Laragy AR, Cockman CJ, Matson CW, Di Giulio RT. Synergistic induction of AHR regulated genes in developmental toxicity from co-exposure to two model PAHs in zebrafish. Aquatic Toxicology (Amsterdam, Netherlands). 85: 241-50. PMID 17964672 DOI: 10.1016/J.Aquatox.2007.09.005  0.637
2006 Billiard SM, Timme-Laragy AR, Wassenberg DM, Cockman C, Di Giulio RT. The role of the aryl hydrocarbon receptor pathway in mediating synergistic developmental toxicity of polycyclic aromatic hydrocarbons to zebrafish. Toxicological Sciences : An Official Journal of the Society of Toxicology. 92: 526-36. PMID 16687390 DOI: 10.1093/Toxsci/Kfl011  0.693
2006 Timme-Laragy AR, Levin ED, Di Giulio RT. Developmental and behavioral effects of embryonic exposure to the polybrominated diphenylether mixture DE-71 in the killifish (Fundulus heteroclitus). Chemosphere. 62: 1097-104. PMID 16045967 DOI: 10.1016/J.Chemosphere.2005.05.037  0.514
2005 Timme-Laragy AR, Meyer JN, Waterland RA, Di Giulio RT. Analysis of CpG methylation in the killifish CYP1A promoter. Comparative Biochemistry and Physiology. Toxicology & Pharmacology : Cbp. 141: 406-11. PMID 16257583 DOI: 10.1016/J.Cbpc.2005.09.009  0.545
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