James E. Darnell - Publications

Affiliations: 
Rockefeller University, New York, NY, United States 
Area:
STATs, development
Website:
http://www.rockefeller.edu/research/faculty/abstract.php?id=112

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Year Citation  Score
2015 Mertens C, Haripal B, Klinge S, Darnell JE. Mutations in the linker domain affect phospho-STAT3 function and suggest targets for interrupting STAT3 activity. Proceedings of the National Academy of Sciences of the United States of America. PMID 26553978 DOI: 10.1073/pnas.1515876112  1
2013 Darnell JE. Joys and surprises of a career studying eukaryotic gene expression. The Journal of Biological Chemistry. 288: 12957-66. PMID 23525107 DOI: 10.1074/jbc.X113.471722  1
2013 Darnell JE. Reflections on the history of pre-mRNA processing and highlights of current knowledge: a unified picture. Rna (New York, N.Y.). 19: 443-60. PMID 23440351 DOI: 10.1261/rna.038596.113  1
2012 Stark GR, Darnell JE. The JAK-STAT pathway at twenty. Immunity. 36: 503-14. PMID 22520844 DOI: 10.1016/j.immuni.2012.03.013  1
2011 Schindler C, Shuai K, Prezioso VR, Darnell JE. Pillars article: Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. Science. 1992. 257: 809-813. Journal of Immunology (Baltimore, Md. : 1950). 187: 5489-94. PMID 22102732  1
2010 Darnell JE. STAT3, HIF-1, glucose addiction and Warburg effect. Aging. 2: 890-1. PMID 21149895  1
2009 Ahmed ST, Darnell JE. Serpin B3/B4, activated by STAT3, promote survival of squamous carcinoma cells. Biochemical and Biophysical Research Communications. 378: 821-5. PMID 19070595 DOI: 10.1016/j.bbrc.2008.11.147  1
2008 Betz A, Ryoo HD, Steller H, Darnell JE. STAT92E is a positive regulator of Drosophila inhibitor of apoptosis 1 (DIAP/1) and protects against radiation-induced apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 105: 13805-10. PMID 18779571 DOI: 10.1073/pnas.0806291105  1
2007 Darnell JE. Interferon research: impact on understanding transcriptional control. Current Topics in Microbiology and Immunology. 316: 155-63. PMID 17969447 DOI: 10.1007/978-3-540-71329-6-8  1
2007 Ginsberg M, Czeko E, Müller P, Ren Z, Chen X, Darnell JE. Amino acid residues required for physical and cooperative transcriptional interaction of STAT3 and AP-1 proteins c-Jun and c-Fos. Molecular and Cellular Biology. 27: 6300-8. PMID 17636030 DOI: 10.1128/MCB.00613-07  1
2006 Mertens C, Zhong M, Krishnaraj R, Zou W, Chen X, Darnell JE. Dephosphorylation of phosphotyrosine on STAT1 dimers requires extensive spatial reorientation of the monomers facilitated by the N-terminal domain. Genes & Development. 20: 3372-81. PMID 17182865 DOI: 10.1101/gad.1485406  1
2006 Betz A, Darnell JE. A Hopscotch-chromatin connection. Nature Genetics. 38: 977-9. PMID 16941005 DOI: 10.1038/ng0906-977  1
2006 Leslie K, Lang C, Devgan G, Azare J, Berishaj M, Gerald W, Kim YB, Paz K, Darnell JE, Albanese C, Sakamaki T, Pestell R, Bromberg J. Cyclin D1 is transcriptionally regulated by and required for transformation by activated signal transducer and activator of transcription 3. Cancer Research. 66: 2544-52. PMID 16510571 DOI: 10.1158/0008-5472.CAN-05-2203  1
2005 Darnell JE. Validating Stat3 in cancer therapy. Nature Medicine. 11: 595-6. PMID 15937466 DOI: 10.1038/nm0605-595  1
2005 Shen Y, La Perle KM, Levy DE, Darnell JE. Reduced STAT3 activity in mice mimics clinical disease syndromes. Biochemical and Biophysical Research Communications. 330: 305-9. PMID 15781265 DOI: 10.1016/j.bbrc.2005.02.154  1
2005 Mao X, Ren Z, Parker GN, Sondermann H, Pastorello MA, Wang W, McMurray JS, Demeler B, Darnell JE, Chen X. Structural bases of unphosphorylated STAT1 association and receptor binding. Molecular Cell. 17: 761-71. PMID 15780933 DOI: 10.1016/j.molcel.2005.02.021  1
2005 Zhong M, Henriksen MA, Takeuchi K, Schaefer O, Liu B, ten Hoeve J, Ren Z, Mao X, Chen X, Shuai K, Darnell JE. Implications of an antiparallel dimeric structure of nonphosphorylated STAT1 for the activation-inactivation cycle. Proceedings of the National Academy of Sciences of the United States of America. 102: 3966-71. PMID 15753310 DOI: 10.1073/pnas.0501063102  1
2004 Paz K, Socci ND, van Nimwegen E, Viale A, Darnell JE. Transformation fingerprint: induced STAT3-C, v-Src and Ha-Ras cause small initial changes but similar established profiles in mRNA. Oncogene. 23: 8455-63. PMID 15378015 DOI: 10.1038/sj.onc.1207803  1
2004 Shen Y, Schlessinger K, Zhu X, Meffre E, Quimby F, Levy DE, Darnell JE. Essential role of STAT3 in postnatal survival and growth revealed by mice lacking STAT3 serine 727 phosphorylation. Molecular and Cellular Biology. 24: 407-19. PMID 14673173 DOI: 10.1128/MCB.24.1.407-419.2004  1
2003 Lerner L, Henriksen MA, Zhang X, Darnell JE. STAT3-dependent enhanceosome assembly and disassembly: synergy with GR for full transcriptional increase of the alpha 2-macroglobulin gene. Genes & Development. 17: 2564-77. PMID 14522952 DOI: 10.1101/gad.1135003  1
2003 Zakharova N, Lymar ES, Yang E, Malik S, Zhang JJ, Roeder RG, Darnell JE. Distinct transcriptional activation functions of STAT1alpha and STAT1beta on DNA and chromatin templates. The Journal of Biological Chemistry. 278: 43067-73. PMID 12939262 DOI: 10.1074/jbc.M308166200  1
2003 Yang E, van Nimwegen E, Zavolan M, Rajewsky N, Schroeder M, Magnasco M, Darnell JE. Decay rates of human mRNAs: correlation with functional characteristics and sequence attributes. Genome Research. 13: 1863-72. PMID 12902380 DOI: 10.1101/gr.1272403  1
2003 Yang E, Lerner L, Besser D, Darnell JE. Independent and cooperative activation of chromosomal c-fos promoter by STAT3. The Journal of Biological Chemistry. 278: 15794-9. PMID 12600988 DOI: 10.1074/jbc.M213073200  1
2003 Chen X, Bhandari R, Vinkemeier U, Van Den Akker F, Darnell JE, Kuriyan J. A reinterpretation of the dimerization interface of the N-terminal domains of STATs. Protein Science : a Publication of the Protein Society. 12: 361-5. PMID 12538899 DOI: 10.1110/ps.0218903  1
2002 Darnell JE. Transcription factors as targets for cancer therapy. Nature Reviews. Cancer. 2: 740-9. PMID 12360277 DOI: 10.1038/nrc906  1
2002 Darnell JE. Special Achienvement in Medical Science Award. The surprises of mammalian molecular cell biology. Nature Medicine. 8: 1068-71. PMID 12357235 DOI: 10.1038/nm773  1
2002 Henriksen MA, Betz A, Fuccillo MV, Darnell JE. Negative regulation of STAT92E by an N-terminally truncated STAT protein derived from an alternative promoter site. Genes & Development. 16: 2379-89. PMID 12231627 DOI: 10.1101/gad.1020702  1
2002 Levy DE, Darnell JE. Stats: transcriptional control and biological impact. Nature Reviews. Molecular Cell Biology. 3: 651-62. PMID 12209125 DOI: 10.1038/nrm909  1
2002 Nair JS, DaFonseca CJ, Tjernberg A, Sun W, Darnell JE, Chait BT, Zhang JJ. Requirement of Ca2+ and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-gamma. Proceedings of the National Academy of Sciences of the United States of America. 99: 5971-6. PMID 11972023 DOI: 10.1073/pnas.052159099  1
2002 Yang E, Henriksen MA, Schaefer O, Zakharova N, Darnell JE. Dissociation time from DNA determines transcriptional function in a STAT1 linker mutant. The Journal of Biological Chemistry. 277: 13455-62. PMID 11834743 DOI: 10.1074/jbc.M112038200  1
2002 Brivanlou AH, Darnell JE. Signal transduction and the control of gene expression. Science (New York, N.Y.). 295: 813-8. PMID 11823631 DOI: 10.1126/science.1066355  1
2001 Betz A, Lampen N, Martinek S, Young MW, Darnell JE. A Drosophila PIAS homologue negatively regulates stat92E. Proceedings of the National Academy of Sciences of the United States of America. 98: 9563-8. PMID 11504941 DOI: 10.1073/pnas.171302098  1
2001 Zhang X, Darnell JE. Functional importance of Stat3 tetramerization in activation of the alpha 2-macroglobulin gene. The Journal of Biological Chemistry. 276: 33576-81. PMID 11438543 DOI: 10.1074/jbc.M104978200  1
2001 Shen Y, Devgan G, Darnell JE, Bromberg JF. Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1. Proceedings of the National Academy of Sciences of the United States of America. 98: 1543-8. PMID 11171987 DOI: 10.1073/pnas.041588198  1
2000 Bromberg J, Darnell JE. The role of STATs in transcriptional control and their impact on cellular function. Oncogene. 19: 2468-73. PMID 10851045 DOI: 10.1038/sj.onc.1203476  1
1999 Bromberg JF, Darnell JE. Potential roles of Stat1 and Stat3 in cellular transformation. Cold Spring Harbor Symposia On Quantitative Biology. 64: 425-8. PMID 11232317  1
1999 Zhang X, Wrzeszczynska MH, Horvath CM, Darnell JE. Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation. Molecular and Cellular Biology. 19: 7138-46. PMID 10490649  1
1999 Haspel RL, Darnell JE. A nuclear protein tyrosine phosphatase is required for the inactivation of Stat1. Proceedings of the National Academy of Sciences of the United States of America. 96: 10188-93. PMID 10468584 DOI: 10.1073/pnas.96.18.10188  1
1999 Bromberg JF, Wrzeszczynska MH, Devgan G, Zhao Y, Pestell RG, Albanese C, Darnell JE. Stat3 as an oncogene. Cell. 98: 295-303. PMID 10458605 DOI: 10.1016/S0092-8674(00)81959-5  1
1999 Yang E, Wen Z, Haspel RL, Zhang JJ, Darnell JE. The linker domain of Stat1 is required for gamma interferon-driven transcription. Molecular and Cellular Biology. 19: 5106-12. PMID 10373559  1
1999 Darnell JE. E.B. Wilson Lecture, 1998. Eukaryotic RNAs: once more from the beginning. Molecular Biology of the Cell. 10: 1685-92. PMID 10359589  1
1999 Kuriyan J, Darnell JE. An SH2 domain in disguise. Nature. 398: 22-3, 25. PMID 10078523 DOI: 10.1038/17916  1
1999 John S, Vinkemeier U, Soldaini E, Darnell JE, Leonard WJ. The significance of tetramerization in promoter recruitment by Stat5. Molecular and Cellular Biology. 19: 1910-8. PMID 10022878  1
1999 Besser D, Bromberg JF, Darnell JE, Hanafusa H. A single amino acid substitution in the v-Eyk intracellular domain results in activation of Stat3 and enhances cellular transformation. Molecular and Cellular Biology. 19: 1401-9. PMID 9891073  1
1998 Zhang JJ, Zhao Y, Chait BT, Lathem WW, Ritzi M, Knippers R, Darnell JE. Ser727-dependent recruitment of MCM5 by Stat1alpha in IFN-gamma-induced transcriptional activation. The Embo Journal. 17: 6963-71. PMID 9843502 DOI: 10.1093/emboj/17.23.6963  1
1998 Darnell JE. Studies of IFN-induced transcriptional activation uncover the Jak-Stat pathway. Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research. 18: 549-54. PMID 9726434  1
1998 Bromberg JF, Fan Z, Brown C, Mendelsohn J, Darnell JE. Epidermal growth factor-induced growth inhibition requires Stat1 activation. Cell Growth & Differentiation : the Molecular Biology Journal of the American Association For Cancer Research. 9: 505-12. PMID 9690618  1
1998 Chen X, Vinkemeier U, Zhao Y, Jeruzalmi D, Darnell JE, Kuriyan J. Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA. Cell. 93: 827-39. PMID 9630226 DOI: 10.1016/S0092-8674(00)81443-9  1
1998 Bromberg JF, Horvath CM, Besser D, Lathem WW, Darnell JE. Stat3 activation is required for cellular transformation by v-src. Molecular and Cellular Biology. 18: 2553-8. PMID 9566875  1
1998 Vinkemeier U, Moarefi I, Darnell JE, Kuriyan J. Structure of the amino-terminal protein interaction domain of STAT-4. Science (New York, N.Y.). 279: 1048-52. PMID 9461439 DOI: 10.1126/science.279.5353.1048  1
1997 Zhu X, Wen Z, Xu LZ, Darnell JE. Stat1 serine phosphorylation occurs independently of tyrosine phosphorylation and requires an activated Jak2 kinase. Molecular and Cellular Biology. 17: 6618-23. PMID 9343425  1
1997 Darnell JE. STATs and gene regulation. Science (New York, N.Y.). 277: 1630-5. PMID 9287210 DOI: 10.1126/science.277.5332.1630  1
1997 Wen Z, Darnell JE. Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3. Nucleic Acids Research. 25: 2062-7. PMID 9153303 DOI: 10.1093/nar/25.11.2062  1
1997 Horvath CM, Darnell JE. The state of the STATs: recent developments in the study of signal transduction to the nucleus. Current Opinion in Cell Biology. 9: 233-9. PMID 9069254 DOI: 10.1016/S0955-0674(97)80067-1  1
1997 Duncan SA, Zhong Z, Wen Z, Darnell JE. STAT signaling is active during early mammalian development. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 208: 190-8. PMID 9022056 DOI: 10.1002/(SICI)1097-0177(199702)208:2<190::AID-AJA6>3.0.CO;2-D  1
1997 Zhang JJ, Vinkemeier U, Gu W, Chakravarti D, Horvath CM, Darnell JE. Two contact regions between Statl and CBP/p300 in IFN-γ signaling Faseb Journal. 11: A1072.  1
1997 Darnell JE. Signalling genes from the cell surface Faseb Journal. 11: A1009.  1
1996 Zhang JJ, Vinkemeier U, Gu W, Chakravarti D, Horvath CM, Darnell JE. Two contact regions between Stat1 and CBP/p300 in interferon gamma signaling. Proceedings of the National Academy of Sciences of the United States of America. 93: 15092-6. PMID 8986769 DOI: 10.1073/pnas.93.26.15092  0.4
1996 Haspel RL, Salditt-Georgieff M, Darnell JE. The rapid inactivation of nuclear tyrosine phosphorylated Stat1 depends upon a protein tyrosine phosphatase. The Embo Journal. 15: 6262-8. PMID 8947049  1
1996 Horvath CM, Stark GR, Kerr IM, Darnell JE. Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex. Molecular and Cellular Biology. 16: 6957-64. PMID 8943351  1
1996 Weber-Nordt RM, Riley JK, Greenlund AC, Moore KW, Darnell JE, Schreiber RD. Stat3 recruitment by two distinct ligand-induced, tyrosine-phosphorylated docking sites in the interleukin-10 receptor intracellular domain. The Journal of Biological Chemistry. 271: 27954-61. PMID 8910398 DOI: 10.1074/jbc.271.44.27954  1
1996 Vinkemeier U, Cohen SL, Moarefi I, Chait BT, Kuriyan J, Darnell JE. DNA binding of in vitro activated Stat1 alpha, Stat1 beta and truncated Stat1: interaction between NH2-terminal domains stabilizes binding of two dimers to tandem DNA sites. The Embo Journal. 15: 5616-26. PMID 8896455  1
1996 Zong C, Yan R, August A, Darnell JE, Hanafusa H. Unique signal transduction of Eyk: constitutive stimulation of the JAK-STAT pathway by an oncogenic receptor-type tyrosine kinase. The Embo Journal. 15: 4515-25. PMID 8887543  1
1996 Vaisse C, Halaas JL, Horvath CM, Darnell JE, Stoffel M, Friedman JM. Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Nature Genetics. 14: 95-7. PMID 8782827 DOI: 10.1038/ng0996-95  0.56
1996 Bromberg JF, Horvath CM, Wen Z, Schreiber RD, Darnell JE. Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma. Proceedings of the National Academy of Sciences of the United States of America. 93: 7673-8. PMID 8755534 DOI: 10.1073/pnas.93.15.7673  1
1996 Darnell JE. The JAK-STAT pathway: summary of initial studies and recent advances. Recent Progress in Hormone Research. 51: 391-403; discussion . PMID 8701087  1
1996 Hemmann U, Gerhartz C, Heesel B, Sasse J, Kurapkat G, Grötzinger J, Wollmer A, Zhong Z, Darnell JE, Graeve L, Heinrich PC, Horn F. Differential activation of acute phase response factor/Stat3 and Stat1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. II. Src homology SH2 domains define the specificity of stat factor activation. The Journal of Biological Chemistry. 271: 12999-3007. PMID 8662795  1
1996 Yan R, Luo H, Darnell JE, Dearolf CR. A JAK-STAT pathway regulates wing vein formation in Drosophila. Proceedings of the National Academy of Sciences of the United States of America. 93: 5842-7. PMID 8650180 DOI: 10.1073/pnas.93.12.5842  1
1996 Li X, Leung S, Qureshi S, Darnell JE, Stark GR. Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-alpha. The Journal of Biological Chemistry. 271: 5790-4. PMID 8621447 DOI: 10.1074/jbc.271.10.5790  1
1996 Yan R, Small S, Desplan C, Dearolf CR, Darnell JE. Identification of a Stat gene that functions in Drosophila development. Cell. 84: 421-30. PMID 8608596 DOI: 10.1016/S0092-8674(00)81287-8  1
1996 Qureshi SA, Leung S, Kerr IM, Stark GR, Darnell JE. Function of Stat2 protein in transcriptional activation by alpha interferon. Molecular and Cellular Biology. 16: 288-93. PMID 8524306  1
1996 Horvath CM, Darnell JE. The antiviral state induced by alpha interferon and gamma interferon requires transcriptionally active Stat1 protein. Journal of Virology. 70: 647-50. PMID 8523587  1
1995 Copeland NG, Gilbert DJ, Schindler C, Zhong Z, Wen Z, Darnell JE, Mui AL, Miyajima A, Quelle FW, Ihle JN. Distribution of the mammalian Stat gene family in mouse chromosomes. Genomics. 29: 225-8. PMID 8530075 DOI: 10.1006/geno.1995.1235  1
1995 Yan R, Qureshi S, Zhong Z, Wen Z, Darnell JE. The genomic structure of the STAT genes: multiple exons in coincident sites in Stat1 and Stat2. Nucleic Acids Research. 23: 459-63. PMID 7885841 DOI: 10.1093/nar/23.3.459  1
1995 Stahl N, Farruggella TJ, Boulton TG, Zhong Z, Darnell JE, Yancopoulos GD. Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors. Science (New York, N.Y.). 267: 1349-53. PMID 7871433  1
1995 Heim MH, Kerr IM, Stark GR, Darnell JE. Contribution of STAT SH2 groups to specific interferon signaling by the Jak-STAT pathway. Science (New York, N.Y.). 267: 1347-9. PMID 7871432  1
1995 Sengupta TK, Chen A, Zhong Z, Darnell JE, Ivashkiv LB. Activation of monocyte effector genes and STAT family transcription factors by inflammatory synovial fluid is independent of interferon gamma. The Journal of Experimental Medicine. 181: 1015-25. PMID 7869026 DOI: 10.1084/jem.181.3.1015  1
1995 Gronowski AM, Zhong Z, Wen Z, Thomas MJ, Darnell JE, Rotwein P. In vivo growth hormone treatment rapidly stimulates the tyrosine phosphorylation and activation of Stat3. Molecular Endocrinology (Baltimore, Md.). 9: 171-7. PMID 7776967 DOI: 10.1210/mend.9.2.7776967  1
1995 Horvath CM, Wen Z, Darnell JE. A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain. Genes & Development. 9: 984-94. PMID 7774815  1
1995 Jacobson NG, Szabo SJ, Weber-Nordt RM, Zhong Z, Schreiber RD, Darnell JE, Murphy KM. Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4. The Journal of Experimental Medicine. 181: 1755-62. PMID 7722452  1
1995 Seidel HM, Milocco LH, Lamb P, Darnell JE, Stein RB, Rosen J. Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity. Proceedings of the National Academy of Sciences of the United States of America. 92: 3041-5. PMID 7708771 DOI: 10.1073/pnas.92.7.3041  1
1995 Boulton TG, Zhong Z, Wen Z, Darnell JE, Stahl N, Yancopoulos GD. STAT3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase. Proceedings of the National Academy of Sciences of the United States of America. 92: 6915-9. PMID 7624343 DOI: 10.1073/pnas.92.15.6915  1
1995 Schindler C, Darnell JE. Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annual Review of Biochemistry. 64: 621-51. PMID 7574495 DOI: 10.1146/annurev.bi.64.070195.003201  1
1995 Wen Z, Zhong Z, Darnell JE. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell. 82: 241-50. PMID 7543024 DOI: 10.1016/0092-8674(95)90311-9  1
1995 Qureshi SA, Salditt-Georgieff M, Darnell JE. Tyrosine-phosphorylated Stat1 and Stat2 plus a 48-kDa protein all contact DNA in forming interferon-stimulated-gene factor 3. Proceedings of the National Academy of Sciences of the United States of America. 92: 3829-33. PMID 7537377  1
1995 Leung S, Qureshi SA, Kerr IM, Darnell JE, Stark GR. Role of STAT2 in the alpha interferon signaling pathway. Molecular and Cellular Biology. 15: 1312-7. PMID 7532278  1
1994 Darnell JE, Kerr IM, Stark GR. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science (New York, N.Y.). 264: 1415-21. PMID 8197455  1
1994 Improta T, Schindler C, Horvath CM, Kerr IM, Stark GR, Darnell JE. Transcription factor ISGF-3 formation requires phosphorylated Stat91 protein, but Stat113 protein is phosphorylated independently of Stat91 protein. Proceedings of the National Academy of Sciences of the United States of America. 91: 4776-80. PMID 8197134 DOI: 10.1073/pnas.91.11.4776  1
1994 Zhong Z, Wen Z, Darnell JE. Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science (New York, N.Y.). 264: 95-8. PMID 8140422  1
1994 Ruff-Jamison S, Zhong Z, Wen Z, Chen K, Darnell JE, Cohen S. Epidermal growth factor and lipopolysaccharide activate Stat3 transcription factor in mouse liver. The Journal of Biological Chemistry. 269: 21933-5. PMID 8071311  1
1994 Weinstein DC, Ruiz i Altaba A, Chen WS, Hoodless P, Prezioso VR, Jessell TM, Darnell JE. The winged-helix transcription factor HNF-3 beta is required for notochord development in the mouse embryo. Cell. 78: 575-88. PMID 8069910 DOI: 10.1016/0092-8674(94)90523-1  1
1994 Duncan SA, Manova K, Chen WS, Hoodless P, Weinstein DC, Bachvarova RF, Darnell JE. Expression of transcription factor HNF-4 in the extraembryonic endoderm, gut, and nephrogenic tissue of the developing mouse embryo: HNF-4 is a marker for primary endoderm in the implanting blastocyst. Proceedings of the National Academy of Sciences of the United States of America. 91: 7598-602. PMID 8052626 DOI: 10.1073/pnas.91.16.7598  1
1994 Darnell JE. Spending to save: financial reform for the medicine of the future. Annals of the New York Academy of Sciences. 729: 127. PMID 7998723 DOI: 10.1111/j.1749-6632.1994.tb12222.x  1
1994 Chen WS, Manova K, Weinstein DC, Duncan SA, Plump AS, Prezioso VR, Bachvarova RF, Darnell JE. Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos. Genes & Development. 8: 2466-77. PMID 7958910  1
1994 Zhong Z, Wen Z, Darnell JE. Stat3 and Stat4: members of the family of signal transducers and activators of transcription. Proceedings of the National Academy of Sciences of the United States of America. 91: 4806-10. PMID 7545930 DOI: 10.1073/pnas.91.11.4806  1
1994 Zhong W, Mirkovitch J, Darnell JE. Tissue-specific regulation of mouse hepatocyte nuclear factor 4 expression. Molecular and Cellular Biology. 14: 7276-84. PMID 7523862  1
1994 Shuai K, Horvath CM, Huang LH, Qureshi SA, Cowburn D, Darnell JE. Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions. Cell. 76: 821-8. PMID 7510216 DOI: 10.1016/0092-8674(94)90357-3  1
1993 Pearse RN, Feinman R, Shuai K, Darnell JE, Ravetch JV. Interferon gamma-induced transcription of the high-affinity Fc receptor for IgG requires assembly of a complex that includes the 91-kDa subunit of transcription factor ISGF3. Proceedings of the National Academy of Sciences of the United States of America. 90: 4314-8. PMID 8483949  1
1993 Zhong W, Sladek FM, Darnell JE. The expression pattern of a Drosophila homolog to the mouse transcription factor HNF-4 suggests a determinative role in gut formation. The Embo Journal. 12: 537-44. PMID 8440243  1
1993 Sadowski HB, Shuai K, Darnell JE, Gilman MZ. A common nuclear signal transduction pathway activated by growth factor and cytokine receptors. Science (New York, N.Y.). 261: 1739-44. PMID 8397445  1
1993 Kanno Y, Kozak CA, Schindler C, Driggers PH, Ennist DL, Gleason SL, Darnell JE, Ozato K. The genomic structure of the murine ICSBP gene reveals the presence of the gamma interferon-responsive element, to which an ISGF3 alpha subunit (or similar) molecule binds. Molecular and Cellular Biology. 13: 3951-63. PMID 8321202  1
1993 Lai E, Clark KL, Burley SK, Darnell JE. Hepatocyte nuclear factor 3/fork head or "winged helix" proteins: a family of transcription factors of diverse biologic function. Proceedings of the National Academy of Sciences of the United States of America. 90: 10421-3. PMID 8248124  1
1993 Ruiz i Altaba A, Prezioso VR, Darnell JE, Jessell TM. Sequential expression of HNF-3 beta and HNF-3 alpha by embryonic organizing centers: the dorsal lip/node, notochord and floor plate. Mechanisms of Development. 44: 91-108. PMID 8155584 DOI: 10.1016/0925-4773(93)90060-B  1
1993 Müller M, Laxton C, Briscoe J, Schindler C, Improta T, Darnell JE, Stark GR, Kerr IM. Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathways. The Embo Journal. 12: 4221-8. PMID 7693454  1
1993 Shuai K, Stark GR, Kerr IM, Darnell JE. A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma. Science (New York, N.Y.). 261: 1744-6. PMID 7690989  1
1993 Khan KD, Shuai K, Lindwall G, Maher SE, Darnell JE, Bothwell AL. Induction of the Ly-6A/E gene by interferon alpha/beta and gamma requires a DNA element to which a tyrosine-phosphorylated 91-kDa protein binds. Proceedings of the National Academy of Sciences of the United States of America. 90: 6806-10. PMID 7688129  1
1993 Shuai K, Ziemiecki A, Wilks AF, Harpur AG, Sadowski HB, Gilman MZ, Darnell JE. Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins. Nature. 366: 580-3. PMID 7504784 DOI: 10.1038/366580a0  1
1992 Kuo CJ, Conley PB, Chen L, Sladek FM, Darnell JE, Crabtree GR. A transcriptional hierarchy involved in mammalian cell-type specification. Nature. 355: 457-61. PMID 1734282 DOI: 10.1038/355457a0  1
1992 Mirkovitch J, Decker T, Darnell JE. Interferon induction of gene transcription analyzed by in vivo footprinting. Molecular and Cellular Biology. 12: 1-9. PMID 1729591  1
1992 Sladek FM, Darnell JE. Mechanisms of liver-specific gene expression. Current Opinion in Genetics & Development. 2: 256-9. PMID 1638120 DOI: 10.1016/S0959-437X(05)80282-5  1
1992 Veals SA, Schindler C, Leonard D, Fu XY, Aebersold R, Darnell JE, Levy DE. Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins. Molecular and Cellular Biology. 12: 3315-24. PMID 1630447  1
1992 Avraham KB, Prezioso VR, Chen WS, Lai E, Sladek FM, Zhong W, Darnell JE, Jenkins NA, Copeland NG. Murine chromosomal location of four hepatocyte-enriched transcription factors: HNF-3 alpha, HNF-3 beta, HNF-3 gamma, and HNF-4. Genomics. 13: 264-8. PMID 1612587 DOI: 10.1016/0888-7543(92)90241-J  1
1992 Fu XY, Schindler C, Improta T, Aebersold R, Darnell JE. The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction. Proceedings of the National Academy of Sciences of the United States of America. 89: 7840-3. PMID 1502204  1
1992 Schindler C, Fu XY, Improta T, Aebersold R, Darnell JE. Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha. Proceedings of the National Academy of Sciences of the United States of America. 89: 7836-9. PMID 1502203  1
1992 Schindler C, Shuai K, Prezioso VR, Darnell JE. Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. Science (New York, N.Y.). 257: 809-13. PMID 1496401  1
1992 Mirkovitch J, Darnell JE. Mapping of RNA polymerase on mammalian genes in cells and nuclei. Molecular Biology of the Cell. 3: 1085-94. PMID 1384813  1
1992 Xanthopoulos KG, Cannon PD, Robinson GS, Mirkovitch J, Darnell JE. Transiently and stably introduced CCAAT/enhancer-binding-protein genes are constitutively expressed in cultured cells. European Journal of Biochemistry / Febs. 208: 501-9. PMID 1325913  1
1992 Mietus-Snyder M, Sladek FM, Ginsburg GS, Kuo CF, Ladias JA, Darnell JE, Karathanasis SK. Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells. Molecular and Cellular Biology. 12: 1708-18. PMID 1312668  1
1992 Shuai K, Schindler C, Prezioso VR, Darnell JE. Activation of transcription by IFN-gamma: tyrosine phosphorylation of a 91-kD DNA binding protein. Science (New York, N.Y.). 258: 1808-12. PMID 1281555  1
1992 Tönjes RR, Xanthopoulos KG, Darnell JE, Paul D. Transcriptional control in hepatocytes of normal andc14Cos albino deletion mice Embo Journal. 11: 127-133.  1
1991 Xanthopoulos KG, Prezioso VR, Chen WS, Sladek FM, Cortese R, Darnell JE. The different tissue transcription patterns of genes for HNF-1, C/EBP, HNF-3, and HNF-4, protein factors that govern liver-specific transcription. Proceedings of the National Academy of Sciences of the United States of America. 88: 3807-11. PMID 2023930  1
1991 Mirkovitch J, Darnell JE. Rapid in vivo footprinting technique identifies proteins bound to the TTR gene in the mouse liver. Genes & Development. 5: 83-93. PMID 1989908  1
1991 Decker T, Lew DJ, Mirkovitch J, Darnell JE. Cytoplasmic activation of GAF, an IFN-gamma-regulated DNA-binding factor. The Embo Journal. 10: 927-32. PMID 1901265  0.6
1991 Lew DJ, Decker T, Strehlow I, Darnell JE. Overlapping elements in the guanylate-binding protein gene promoter mediate transcriptional induction by alpha and gamma interferons. Molecular and Cellular Biology. 11: 182-91. PMID 1898761  1
1991 Herbst RS, Nielsch U, Sladek F, Lai E, Babiss LE, Darnell JE. Differential regulation of hepatocyte-enriched transcription factors explains changes in albumin and transthyretin gene expression among hepatoma cells. The New Biologist. 3: 289-96. PMID 1878351  1
1991 Decker T, Lew DJ, Darnell JE. Two distinct alpha-interferon-dependent signal transduction pathways may contribute to activation of transcription of the guanylate-binding protein gene. Molecular and Cellular Biology. 11: 5147-53. PMID 1833631  1
1991 Kuo FC, Hwu WL, Valle D, Darnell JE. Colocalization in pericentral hepatocytes in adult mice and similarity in developmental expression pattern of ornithine aminotransferase and glutamine synthetase mRNA. Proceedings of the National Academy of Sciences of the United States of America. 88: 9468-72. PMID 1682918  1
1991 Kuo FC, Darnell JE. Evidence that interaction of hepatocytes with the collecting (hepatic) veins triggers position-specific transcription of the glutamine synthetase and ornithine aminotransferase genes in the mouse liver. Molecular and Cellular Biology. 11: 6050-8. PMID 1682797  1
1991 Lai E, Prezioso VR, Tao WF, Chen WS, Darnell JE. Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head. Genes & Development. 5: 416-27. PMID 1672118  1
1991 Decker T, Lew DJ, Mirkovitch J, Darnell JE. Cytoplasmic activation of GAP, an IFN-γ-regulated DNA-binding factor Embo Journal. 10: 927-932.  1
1990 Kuo CF, Xanthopoulos KG, Darnell JE. Fetal and adult localization of C/EBP: evidence for combinatorial action of transcription factors in cell-specific gene expression. Development (Cambridge, England). 109: 473-81. PMID 2401206  1
1990 Costa RH, Van Dyke TA, Yan C, Kuo F, Darnell JE. Similarities in transthyretin gene expression and differences in transcription factors: liver and yolk sac compared to choroid plexus. Proceedings of the National Academy of Sciences of the United States of America. 87: 6589-93. PMID 2395861  1
1990 Herbst RS, Boczko EM, Darnell JE, Babiss LE. The mouse albumin enhancer contains a negative regulatory element that interacts with a novel DNA-binding protein. Molecular and Cellular Biology. 10: 3896-905. PMID 2370857  1
1990 Pine R, Decker T, Kessler DS, Levy DE, Darnell JE. Purification and cloning of interferon-stimulated gene factor 2 (ISGF2): ISGF2 (IRF-1) can bind to the promoters of both beta interferon- and interferon-stimulated genes but is not a primary transcriptional activator of either. Molecular and Cellular Biology. 10: 2448-57. PMID 2342456  1
1990 Paulson KE, Darnell JE, Rushmore T, Pickett CB. Analysis of the upstream elements of the xenobiotic compound-inducible and positionally regulated glutathione S-transferase Ya gene. Molecular and Cellular Biology. 10: 1841-52. PMID 2325638  1
1990 Sladek FM, Zhong WM, Lai E, Darnell JE. Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. Genes & Development. 4: 2353-65. PMID 2279702  1
1990 Fu XY, Kessler DS, Veals SA, Levy DE, Darnell JE. ISGF3, the transcriptional activator induced by interferon alpha, consists of multiple interacting polypeptide chains. Proceedings of the National Academy of Sciences of the United States of America. 87: 8555-9. PMID 2236065  1
1990 Lai E, Prezioso VR, Smith E, Litvin O, Costa RH, Darnell JE. HNF-3A, a hepatocyte-enriched transcription factor of novel structure is regulated transcriptionally. Genes & Development. 4: 1427-36. PMID 2227418  1
1990 Levy DE, Lew DJ, Decker T, Kessler DS, Darnell JE. Synergistic interaction between interferon-alpha and interferon-gamma through induced synthesis of one subunit of the transcription factor ISGF3. The Embo Journal. 9: 1105-11. PMID 2108862  1
1990 Levy D, Darnell JE. Interferon-dependent transcriptional activation: signal transduction without second messenger involvement? The New Biologist. 2: 923-8. PMID 1706625  1
1990 Yan C, Costa RH, Darnell JE, Chen JD, Van Dyke TA. Distinct positive and negative elements control the limited hepatocyte and choroid plexus expression of transthyretin in transgenic mice. The Embo Journal. 9: 869-78. PMID 1690125  1
1989 Herbst RS, Friedman N, Darnell JE, Babiss LE. Positive and negative regulatory elements in the mouse albumin enhancer. Proceedings of the National Academy of Sciences of the United States of America. 86: 1553-7. PMID 2922398  1
1989 Pine R, Darnell JE. In vivo evidence of interaction between interferon-stimulated gene factors and the interferon-stimulated response element. Molecular and Cellular Biology. 9: 3533-7. PMID 2796995  1
1989 Costa RH, Grayson DR, Darnell JE. Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and alpha 1-antitrypsin genes. Molecular and Cellular Biology. 9: 1415-25. PMID 2786140  1
1989 Xanthopoulos KG, Mirkovitch J, Decker T, Kuo CF, Darnell JE. Cell-specific transcriptional control of the mouse DNA-binding protein mC/EBP. Proceedings of the National Academy of Sciences of the United States of America. 86: 4117-21. PMID 2726767  1
1989 Reich NC, Darnell JE. Differential binding of interferon-induced factors to an oligonucleotide that mediates transcriptional activation. Nucleic Acids Research. 17: 3415-24. PMID 2726484 DOI: 10.1093/nar/17.9.3415  1
1989 Darnell JE. Thoughts about gene regulation and mammalian development. Arzneimittel-Forschung. 39: 1011-4; discussion 1. PMID 2684177  1
1989 Levy DE, Kessler DS, Pine R, Darnell JE. Cytoplasmic activation of ISGF3, the positive regulator of interferon-alpha-stimulated transcription, reconstituted in vitro. Genes & Development. 3: 1362-71. PMID 2606351  1
1989 Xanthopoulos KG, Mirkovitch J, Friedman JM, Darnell JE. The mouse Cebp gene encoding a DNA-binding protein is polymorphic and is located on chromosome 7. Cytogenetics and Cell Genetics. 50: 174-5. PMID 2570675  1
1989 Lew DJ, Decker T, Darnell JE. Alpha interferon and gamma interferon stimulate transcription of a single gene through different signal transduction pathways. Molecular and Cellular Biology. 9: 5404-11. PMID 2555698  1
1989 Vales LD, Darnell JE. Promoter occlusion prevents transcription of adenovirus polypeptide IX mRNA until after DNA replication. Genes & Development. 3: 49-59. PMID 2523329  1
1989 Decker T, Lew DJ, Cheng YS, Levy DE, Darnell JE. Interactions of alpha- and gamma-interferon in the transcriptional regulation of the gene encoding a guanylate-binding protein. The Embo Journal. 8: 2009-14. PMID 2507314  0.32
1989 Kuo CF, Darnell JE. Mouse glutamine synthetase is encoded by a single gene that can be expressed in a localized fashion. Journal of Molecular Biology. 208: 45-56. PMID 2475638 DOI: 10.1016/0022-2836(89)90086-7  1
1989 Grayson DR, Costa RH, Darnell JE. Regulation of hepatocyte-specific gene expression. Annals of the New York Academy of Sciences. 557: 243-55, discussion 2. PMID 2472089  1
1988 Levy DE, Kessler DS, Pine R, Reich N, Darnell JE. Interferon-induced nuclear factors that bind a shared promoter element correlate with positive and negative transcriptional control. Genes & Development. 2: 383-93. PMID 3371658  1
1988 Costa RH, Lai E, Grayson DR, Darnell JE. The cell-specific enhancer of the mouse transthyretin (prealbumin) gene binds a common factor at one site and a liver-specific factor(s) at two other sites. Molecular and Cellular Biology. 8: 81-90. PMID 3336368  1
1988 Grayson DR, Costa RH, Xanthopoulos KG, Darnell JE. One factor recognizes the liver-specific enhancers in alpha 1-antitrypsin and transthyretin genes. Science (New York, N.Y.). 239: 786-8. PMID 3257586  1
1988 Levy D, Reich N, Kessler D, Pine R, Darnell JE. Transcriptional regulation of interferon-stimulated genes: a DNA response element and induced proteins that recognize it. Cold Spring Harbor Symposia On Quantitative Biology. 53: 799-802. PMID 3254784  1
1988 Pine R, Levy DE, Reich N, Darnell JE. Transcriptional stimulation by CaPO4-DNA precipitates. Nucleic Acids Research. 16: 1371-8. PMID 3126485 DOI: 10.1093/nar/16.4.1371  1
1988 Kessler DS, Pine R, Pfeffer LM, Levy DE, Darnell JE. Cells resistant to interferon are defective in activation of a promoter-binding factor. The Embo Journal. 7: 3779-83. PMID 2974800  1
1988 Kuo CF, Paulson KE, Darnell JE. Positional and developmental regulation of glutamine synthetase expression in mouse liver. Molecular and Cellular Biology. 8: 4966-71. PMID 2905422  1
1988 Costa RH, Grayson DR, Xanthopoulos KG, Darnell JE. A liver-specific DNA-binding protein recognizes multiple nucleotide sites in regulatory regions of transthyretin, alpha 1-antitrypsin, albumin, and simian virus 40 genes. Proceedings of the National Academy of Sciences of the United States of America. 85: 3840-4. PMID 2836860  1
1988 Grayson DR, Costa RH, Xanthopoulos KG, Darnell JE. A cell-specific enhancer of the mouse alpha 1-antitrypsin gene has multiple functional regions and corresponding protein-binding sites. Molecular and Cellular Biology. 8: 1055-66. PMID 2835657  1
1988 Kessler DS, Levy DE, Darnell JE. Two interferon-induced nuclear factors bind a single promoter element in interferon-stimulated genes. Proceedings of the National Academy of Sciences of the United States of America. 85: 8521-5. PMID 2460869  1
1988 Reich N, Pine R, Levy D, Darnell JE. Transcription of interferon-stimulated genes is induced by adenovirus particles but is suppressed by E1A gene products. Journal of Virology. 62: 114-9. PMID 2446013  1
1987 Babiss LE, Herbst RS, Bennett AL, Darnell JE. Factors that interact with the rat albumin promoter are present both in hepatocytes and other cell types. Genes & Development. 1: 256-67. PMID 3678823  1
1987 Babiss LE, Friedman JM, Darnell JE. Cellular promoters incorporated into the adenovirus genome. Effect of viral DNA replication on endogenous and exogenous gene transcription. Journal of Molecular Biology. 193: 643-50. PMID 3612788 DOI: 10.1016/0022-2836(87)90347-0  1
1987 Isom I, Georgoff I, Salditt-Georgieff M, Darnell JE. Persistence of liver-specific messenger RNA in cultured hepatocytes: different regulatory events for different genes. The Journal of Cell Biology. 105: 2877-85. PMID 3500953  1
1987 Logan J, Falck-Pedersen E, Darnell JE, Shenk T. A poly(A) addition site and a downstream termination region are required for efficient cessation of transcription by RNA polymerase II in the mouse beta maj-globin gene. Proceedings of the National Academy of Sciences of the United States of America. 84: 8306-10. PMID 3479794  1
1987 Reich N, Evans B, Levy D, Fahey D, Knight E, Darnell JE. Interferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element. Proceedings of the National Academy of Sciences of the United States of America. 84: 6394-8. PMID 3476954  1
1987 Muramatsu M, Darnell JE. U.S.-Japan seminar on "oncogenes in relation to developmental and transcriptional control". Japanese Journal of Cancer Research : Gann. 78: 1287-91. PMID 3121564  1
1987 Friedman JM, Babiss LE, Weiss M, Darnell JE. Hepatoma variants (C2) are defective for transcriptional and post-transcriptional actions from both endogenous and viral genomes. The Embo Journal. 6: 1727-31. PMID 2956094  1
1987 Bennett AL, Paulson KE, Miller RE, Darnell JE. Acquisition of antigens characteristic of adult pericentral hepatocytes by differentiating fetal hepatoblasts in vitro. The Journal of Cell Biology. 105: 1073-85. PMID 2888770  1
1986 Iwamoto S, Eggerding F, Falck-Pederson E, Darnell JE. Transcription unit mapping in adenovirus: regions of termination. Journal of Virology. 59: 112-9. PMID 3712555  1
1986 Levy D, Larner A, Chaudhuri A, Babiss LE, Darnell JE. Interferon-stimulated transcription: isolation of an inducible gene and identification of its regulatory region. Proceedings of the National Academy of Sciences of the United States of America. 83: 8929-33. PMID 3466167  1
1986 Babiss LE, Bennett A, Friedman JM, Darnell JE. DNase I-hypersensitive sites in the 5'-flanking region of the rat serum albumin gene: correlation between chromatin structure and transcriptional activity. Proceedings of the National Academy of Sciences of the United States of America. 83: 6504-8. PMID 3462709  1
1986 Costa RH, Lai E, Darnell JE. Transcriptional control of the mouse prealbumin (transthyretin) gene: both promoter sequences and a distinct enhancer are cell specific. Molecular and Cellular Biology. 6: 4697-708. PMID 3025666  1
1986 Krauter KS, Citron BA, Hsu MT, Powell D, Darnell JE. Isolation and characterization of the alpha 1-antitrypsin gene of mice. Dna (Mary Ann Liebert, Inc.). 5: 29-36. PMID 3007061  1
1986 Babiss LE, Friedman JM, Darnell JE. Cellular promoters incorporated into the adenovirus genome: effects of viral regulatory elements on transcription rates and cell specificity of albumin and beta-globin promoters. Molecular and Cellular Biology. 6: 3798-806. PMID 2948109  1
1986 Friedman JM, Babiss LE, Clayton DF, Darnell JE. Cellular promoters incorporated into the adenovirus genome: cell specificity of albumin and immunoglobulin expression. Molecular and Cellular Biology. 6: 3791-7. PMID 2948108  1
1986 Larner AC, Chaudhuri A, Darnell JE. Transcriptional induction by interferon. New protein(s) determine the extent and length of the induction. The Journal of Biological Chemistry. 261: 453-9. PMID 2934388  1
1986 Darnell JE, Doolittle WF. Speculations on the early course of evolution. Proceedings of the National Academy of Sciences of the United States of America. 83: 1271-5. PMID 2419905  1
1985 Clayton DF, Weiss M, Darnell JE. Liver-specific RNA metabolism in hepatoma cells: variations in transcription rates and mRNA levels. Molecular and Cellular Biology. 5: 2633-41. PMID 3841793  1
1985 Clayton DF, Harrelson AL, Darnell JE. Dependence of liver-specific transcription on tissue organization. Molecular and Cellular Biology. 5: 2623-32. PMID 3841792  1
1985 Citron BA, Darnell JE. Mapping a mammalian mRNA cap site by restriction digestion of hybridized cDNA. Gene. 40: 131-5. PMID 3005119 DOI: 10.1016/0378-1119(85)90032-0  1
1985 Babiss LE, Ginsberg HS, Darnell JE. Adenovirus E1B proteins are required for accumulation of late viral mRNA and for effects on cellular mRNA translation and transport. Molecular and Cellular Biology. 5: 2552-8. PMID 2942759  1
1985 Falck-Pedersen E, Logan J, Shenk T, Darnell JE. Transcription termination within the E1A gene of adenovirus induced by insertion of the mouse beta-major globin terminator element. Cell. 40: 897-905. PMID 2580640 DOI: 10.1016/0092-8674(85)90349-6  1
1985 Darnell JE. RNA. Scientific American. 253: 68-78. PMID 2416052  1
1984 Salditt-Georgieff M, Sheffery M, Krauter K, Darnell JE, Rifkind R, Marks PA. Induced transcription of the mouse beta-globin transcription unit in erythroleukemia cells. Time-course of induction and of changes in chromatin structure. Journal of Molecular Biology. 172: 437-50. PMID 6582280 DOI: 10.1016/S0022-2836(84)80016-9  1
1984 Friedman JM, Chung EY, Darnell JE. Gene expression during liver regeneration. Journal of Molecular Biology. 179: 37-53. PMID 6502711 DOI: 10.1016/0022-2836(84)90305-X  1
1984 Powell DJ, Friedman JM, Oulette AJ, Krauter KS, Darnell JE. Transcriptional and post-transcriptional control of specific messenger RNAs in adult and embryonic liver. Journal of Molecular Biology. 179: 21-35. PMID 6502710 DOI: 10.1016/0022-2836(84)90304-8  1
1984 Larner AC, Jonak G, Cheng YS, Korant B, Knight E, Darnell JE. Transcriptional induction of two genes in human cells by beta interferon. Proceedings of the National Academy of Sciences of the United States of America. 81: 6733-7. PMID 6436820 DOI: 10.1073/pnas.81.21.6733  1
1984 Salditt-Georgieff M, Darnell JE. A precise termination site in the mouse beta-major globin transcription unit. Proceedings of the National Academy of Sciences of the United States of America. 81: 2274. PMID 6371812  1
1984 Jefferson DM, Clayton DF, Darnell JE, Reid LM. Posttranscriptional modulation of gene expression in cultured rat hepatocytes. Molecular and Cellular Biology. 4: 1929-34. PMID 6333585  1
1984 Citron B, Falck-Pedersen E, Salditt-Georgieff M, Darnell JE. Transcription termination occurs within a 1000 base pair region downstream from the poly(A) site of the mouse beta-globin (major) gene. Nucleic Acids Research. 12: 8723-31. PMID 6095210 DOI: 10.1093/nar/12.22.8723  1
1984 Citron B, Falck-Pedersen E, Salditt-Georgieff M, Darnell JE. Transcription termination occurs within a 1000 base pair region downstream from the poly(A) site of the mouse β-globin (major) gene Nucleic Acids Research. 12: 8723-8731. DOI: 10.1093/nar/12.22.8723  1
1983 Babich A, Feldman LT, Nevins JR, Darnell JE, Weinberger C. Effect of adenovirus on metabolism of specific host mRNAs: transport control and specific translational discrimination. Molecular and Cellular Biology. 3: 1212-21. PMID 6688459  1
1983 Clayton DF, Darnell JE. Changes in liver-specific compared to common gene transcription during primary culture of mouse hepatocytes. Molecular and Cellular Biology. 3: 1552-61. PMID 6633533  1
1983 Darnell JE. The processing of RNA. Scientific American. 249: 90-100. PMID 6195735  1
1983 Salditt-Georgieff M, Darnell JE. A precise termination site in the mouse beta major-globin transcription unit. Proceedings of the National Academy of Sciences of the United States of America. 80: 4694-8. PMID 6192441  0.48
1982 Salditt-Georgieff M, Darnell JE. Further evidence that the majority of primary nuclear RNA transcripts in mammalian cells do not contribute to mRNA. Molecular and Cellular Biology. 2: 701-7. PMID 14582165  0.48
1982 Krauter K, Leinwand L, D'Eustachio P, Ruddle F, Darnell JE. Structural genes of the mouse major urinary protein are on chromosome 4. The Journal of Cell Biology. 94: 414-7. PMID 7107707 DOI: 10.1083/jcb.94.2.414  1
1982 Zeevi M, Nevins JR, Darnell JE. Newly formed mRNA lacking polyadenylic acid enters the cytoplasm and the polyribosomes but has a shorter half-life in the absence of polyadenylic acid. Molecular and Cellular Biology. 2: 517-25. PMID 6981059  0.4
1981 Wilson MC, Darnell JE. Control of messenger RNA concentration by differential cytoplasmic half-life. Adenovirus messenger RNAs from transcription units 1A and 1B. Journal of Molecular Biology. 148: 231-51. PMID 7299816  0.76
1981 Derman E, Krauter K, Walling L, Weinberger C, Ray M, Darnell JE. Transcriptional control in the production of liver-specific mRNAs. Cell. 23: 731-9. PMID 7226226 DOI: 10.1016/0092-8674(81)90436-0  1
1981 Zeevi M, Nevins JR, Darnell JE. Nuclear RNA is spliced in the absence of poly(A) addition. Cell. 26: 39-46. PMID 6976837  0.4
1981 Harpold MM, Wilson MC, Darnell JE. Chinese hamster polyadenylated messenger ribonucleic acid: relationship to non-polyadenylated sequences and relative conservation during messenger ribonucleic acid processing. Molecular and Cellular Biology. 1: 188-98. PMID 6152853  0.76
1981 Salditt-Georgieff M, Harpold MM, Wilson MC, Darnell JE. Large heterogeneous nuclear ribonucleic acid has three times as many 5' caps as polyadenylic acid segments, and most caps do not enter polyribosomes. Molecular and Cellular Biology. 1: 179-87. PMID 6152852  0.76
1980 Babich A, Nevins JR, Darnell JE. Early capping of transcripts from the adenovirus major late transcription unit. Nature. 287: 246-8. PMID 7432461 DOI: 10.1038/287246a0  1
1980 Tamm I, Kikuchi T, Darnell JE, Salditt-Georgieff M. Short capped hnRNA precursor chains in HeLa cells: continued synthesis in the presence of 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole. Biochemistry. 19: 2743-8. PMID 7397102  1
1980 Salditt-Georgieff M, Harpold M, Chen-Kiang S, Darnell JE. The addition of 5' cap structures occurs early in hnRNA synthesis and prematurely terminated molecules are capped. Cell. 19: 69-78. PMID 7357608  0.48
1980 Soreq H, Harpold M, Wilson M, Darnell JE. Rate of synthesis and concentration of specific mRNA sequences in cultured Chinese hamster ovary cells compared to liver cells. Biochemical and Biophysical Research Communications. 92: 485-91. PMID 7356477  0.36
1980 Nevins JR, Blanchard JM, Darnell JE. Transcription units of adenovirus type 2. Termination of transcription beyond the poly(A) addition site in early regions 2 and 4. Journal of Molecular Biology. 144: 377-86. PMID 7253021 DOI: 10.1016/0022-2836(80)90096-0  1
1980 Darnell JE, Ziff E, Nevins JR, Wilson M. Variety in the mechanisms of adenovirus gene control. Annals of the New York Academy of Sciences. 354: 466-71. PMID 6939405  1
1980 Wilson MC, Nevins JR, Blanchard JM, Ginsberg HS, Darnell JE. Metabolism of mRNA from the transforming region of adenovirus 2. Cold Spring Harbor Symposia On Quantitative Biology. 44: 447-55. PMID 6933041  1
1980 Weber J, Blanchard JM, Ginsberg H, Darnell JE. Order of polyadenylic acid addition and splicing events in early adenovirus mRNA formation. Journal of Virology. 33: 286-91. PMID 6245233  1
1980 Salditt-Georgieff M, Harpold M, Sawicki S, Nevins J, Darnell JE. Addition of poly(A) to nuclear RNA occurs soon after RNA synthesis. The Journal of Cell Biology. 86: 844-8. PMID 6157696  1
1979 Chen-Kiang S, Nevins JR, Darnell JE. N-6-methyl-adenosine in adenovirus type 2 nuclear RNA is conserved in the formation of messenger RNA. Journal of Molecular Biology. 135: 733-52. PMID 537090  0.4
1979 Nevins JR, Ginsberg HS, Blanchard JM, Wilson MC, Darnell JE. Regulation of the primary expression of the early adenovirus transcription units. Journal of Virology. 32: 727-33. PMID 513202  1
1979 Harpold MM, Dobner PR, Evans R, Bancroft FC, Darnell JE. The synthesis and processing of a nuclear RNA precursor to rat pregrowth hormone messenger RNA. Nucleic Acids Research. 6: 3133-44. PMID 493135  0.6
1979 Harpold MM, Evans RM, Salditt-Georgieff M, Darnell JE. Production of mRNA in Chinese hamster cells: relationship of the rate of synthesis to the cytoplasmic concentration of nine specific mRNA sequences. Cell. 17: 1025-35. PMID 487428  0.6
1979 Fraser NW, Nevins JR, Ziff E, Darnell JE. The major late adenovirus type-2 transcription unit: termination is downstream from the last poly(A) site. Journal of Molecular Biology. 129: 643-56. PMID 480353 DOI: 10.1016/0022-2836(79)90474-1  1
1979 Soreq H, Harpold M, Evans R, Darnell JE, Bancroft FC. Rat growth hormone gene: intervening sequences separate the mRNA regions. Nucleic Acids Research. 6: 2471-82. PMID 461195  0.36
1979 Sehgal PB, Fraser NW, Darnell JE. Early Ad-2 transcription units: only promoter-proximal RNA continues to be made in the presence of DRB. Virology. 94: 185-91. PMID 442531  0.48
1979 Wilson MC, Fraser NW, Darnell JE. Mapping of RNA initiation sites by high doses of uv irradiation: evidence for three independent promoters within the left 11% of the Ad-2 genome. Virology. 94: 175-84. PMID 442530  0.76
1979 Evans R, Weber J, Ziff E, Darnell JE. Premature termination during adenovirus transcription. Nature. 278: 367-70. PMID 423992  1
1979 Fraser NW, Sehgal PB, Darnell JE. Multiple discrete sites for premature RNA chain termination late in adenovirus-2 infection: enhancement by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole. Proceedings of the National Academy of Sciences of the United States of America. 76: 2571-5. PMID 111239  0.48
1978 Wilson MC, Sawicki SG, White PA, Darnell JE. A correlation between the rate of poly(A) shortening and half-life of messenger RNA in adenovirus transformed cells. Journal of Molecular Biology. 126: 23-36. PMID 739542  0.76
1978 Nevins JR, Darnell JE. Steps in the processing of Ad2 mRNA: poly(A)+ nuclear sequences are conserved and poly(A) addition precedes splicing. Cell. 15: 1477-93. PMID 729004  0.4
1978 Fraser NW, Sehgal PB, Darnell JE. DRB-induced premature termination of late adenovirus transcription. Nature. 272: 590-3. PMID 643052  0.48
1978 Nevins JR, Darnell JE. Groups of adenovirus type 2 mRNA's derived from a large primary transcript: probable nuclear origin and possible common 3' ends. Journal of Virology. 25: 811-23. PMID 642075  0.4
1978 Wilson MC, Sawicki SG, Salditt-Georgieff M, Darnell JE. Adenovirus type 2 mRNA in transformed cells: map positions and difference in transport time. Journal of Virology. 25: 97-103. PMID 621789  1
1978 Blanchard JM, Weber J, Jelinek W, Darnell JE. In vitro RNA-RNA splicing in adenovirus 2 mRNA formation. Proceedings of the National Academy of Sciences of the United States of America. 75: 5344-8. PMID 281684  1
1978 Darnell JE, Evans R, Fraser N, Goldberg S, Nevins J, Salditt-Georgieff M, Schwartz H, Weber J, Ziff E. The definition of transcription units for mRNA. Cold Spring Harbor Symposia On Quantitative Biology. 42: 515-22. PMID 277360  1
1978 Jelinek W, Evans R, Wilson M, Salditt-Georgieff M, Darnell JE. Oligonucleotides in heterogeneous nuclear RNA: similarity of inverted repeats and RNA from repetitious DNA sites. Biochemistry. 17: 2776-83. PMID 99161  0.48
1977 Evans RM, Fraser N, Ziff E, Weber J, Wilson M, Darnell JE. The initiation sites for RNA transcription in Ad2 DNA. Cell. 12: 733-9. PMID 922890 DOI: 10.1016/0092-8674(77)90273-2  1
1977 Sawicki SG, Jelinek W, Darnell JE. 3'-Terminal addition to HeLa cell nuclear and cytoplasmic poly (A). Journal of Molecular Biology. 113: 219-35. PMID 881735 DOI: 10.1016/0022-2836(77)90051-1  1
1976 Sommer S, Salditt-Georgieff M, Bachenheimer S, Darnell JE, Furuichi Y, Morgan M, Shatkin AJ. The methylation of adenovirus-specific nuclear and cytoplasmic RNA. Nucleic Acids Research. 3: 749-65. PMID 1272797  1
1976 Sehgal PB, Darnell JE, Tamm I. The inhibition by DRB (5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole) of hnRNA and mRNA production in HeLa cells. Cell. 9: 473-80. PMID 1086720 DOI: 10.1016/0092-8674(76)90092-1  1
1976 Sehgal PB, Derman E, Molloy GR, Tamm I, Darnell JE. 5,6-Dichloro-1-Beta-D-ribofuranosylbenzimidazole inhibits initiation of nuclear heterogeneous RNA chains in HeLa cells. Science (New York, N.Y.). 194: 431-3. PMID 982026 DOI: 10.1126/science.982026  1
1976 Salditt-Georgieff M, Jelinek W, Darnell JE, Furuichi Y, Morgan M, Shatkin A. Methyl labeling of HeLa cell hnRNA: a comparison with mRNA. Cell. 7: 227-37. PMID 954080 DOI: 10.1016/0092-8674(76)90022-2  1
1975 Furuichi Y, Morgan M, Shatkin AJ, Jelinek W, Salditt-Georgieff M, Darnell JE. Methylated, blocked 5 termini in HeLa cell mRNA. Proceedings of the National Academy of Sciences of the United States of America. 72: 1904-8. PMID 1057180 DOI: 10.1073/pnas.72.5.1904  1
1974 Fernandez Muñoz R, Darnell JE. Poly(A) in mRNA does not contribute to secondary structure necessary for protein synthesis. Cell. 2: 247-52. PMID 4472240 DOI: 10.1016/0092-8674(74)90018-X  1
1970 Strauss JH, Burge BW, Darnell JE. Carbohydrate content of the membrane protein of Sindbis virus. Journal of Molecular Biology. 47: 437-48. PMID 5418165 DOI: 10.1016/0022-2836(70)90313-X  1
1970 Soeiro R, Darnell JE. A comparison between heterogeneous nuclear RNA and polysomal messenger RNA in HeLa cells by RNA-DNA hybridization. The Journal of Cell Biology. 44: 467-75. PMID 5415231  1
1970 Darnell JE, Levintow L, Scharff MD. Harry Eagle. Journal of Cellular Physiology. 76: 241-52. PMID 4925975 DOI: 10.1002/jcp.1040760304  1
1970 Lindberg U, Darnell JE. SV40-specific RNA in the nucleus and polyribosomes of transformed cells. Proceedings of the National Academy of Sciences of the United States of America. 65: 1089-96. PMID 4314900  1
1969 Soeiro R, Darnell JE. Competition hybridization by "pre-saturation" of HeLa cell DNA. Journal of Molecular Biology. 44: 551-62. PMID 5388124  1
1969 Maden BE, Vaughan MH, Warner JR, Darnell JE. Effects of valine deprivation on ribosome formation in HeLa cells. Journal of Molecular Biology. 45: 265-75. PMID 5367028  1
1969 Bernhardt D, Darnell JE. tRNA synthesis in HeLa cells: a precursor to tRNA and the effects of methionine starvation on tRNA synthesis. Journal of Molecular Biology. 42: 43-56. PMID 4185508  1
1968 Soeiro R, Vaughan MH, Darnell JE. The effect of puromycin on intranuclear steps in ribosome biosynthesis. The Journal of Cell Biology. 36: 91-101. PMID 19866729  0.96
1968 Soeiro R, Vaughan MH, Darnell JE. The effect of puromycin on intranuclear steps in ribosome biosynthesis. The Journal of Cell Biology. 36: 91-101. PMID 19806696 DOI: 10.1083/jcb.36.1.91  1
1968 Soeiro R, Vaughan MH, Warner JR, Darnell JE. The turnover of nuclear DNA-like RNA in HeLa cells. The Journal of Cell Biology. 39: 112-8. PMID 5678443  1
1967 Vaughan MH, Warner JR, Darnell JE. Ribosomal precursor particles in the HeLa cell nucleus. Journal of Molecular Biology. 25: 235-51. PMID 6034101  1
1967 Vaughan MH, Soeiro R, Warner JR, Darnell JE. The effects of methionine deprivation on ribosome synthesis in HeLa cells. Proceedings of the National Academy of Sciences of the United States of America. 58: 1527-34. PMID 5237886  1
1966 Warner JR, Girard M, Latham H, Darnell JE. Ribosome formation in HeLa cells in the absence of protein synthesis. Journal of Molecular Biology. 19: 373-82. PMID 5969072  1
1966 Soeiro R, Birnboim HC, Darnell JE. Rapidly labeled HeLa cell nuclear RNA. II. Base composition and cellular localization of a heterogeneous RNA fraction. Journal of Molecular Biology. 19: 362-72. PMID 5969071  1
1966 Warner JR, Soeiro R, Birnboim HC, Girard M, Darnell JE. Rapidly labeled HeLa cell nuclear RNA. I. Identification by zone sedimentation of a heterogeneous fraction separate from ribosomal precursor RNA. Journal of Molecular Biology. 19: 349-61. PMID 5969070  1
1966 Baltimore D, Girard M, Darnell JE. Aspects of the synthesis of poliovirus RNA and the formation of virus particles. Virology. 29: 179-89. PMID 4287327  0.56
1965 GIRARD M, LATHAM H, PENMAN S, DARNELL JE. ENTRANCE OF NEWLY FORMED MESSENGER RNA AND RIBOSOMES INTO HELA CELL CYTOPLASM. Journal of Molecular Biology. 11: 187-201. PMID 14290358  0.76
1964 PENMAN S, BECKER Y, DARNELL JE. A CYTOPLASMIC STRUCTURE INVOLVED IN THE SYNTHESIS AND ASSEMBLY OF POLIOVIRUS COMPONENTS. Journal of Molecular Biology. 8: 541-55. PMID 14153525  0.76
1964 GIRARD M, PENMAN S, DARNELL JE. THE EFFECT OF ACTINOMYCIN ON RIBOSOME FORMATION IN HELA CELLS. Proceedings of the National Academy of Sciences of the United States of America. 51: 205-11. PMID 14124318  0.76
1964 BALTIMORE D, BECKER Y, DARNELL JE. VIRUS-SPECIFIC DOUBLE-STRANDED RNA IN POLIOVIRUS-INFECTED CELLS. Science (New York, N.Y.). 143: 1034-6. PMID 14107425  0.76
1963 Penman S, Scherrer K, Becker Y, Darnell JE. POLYRIBOSOMES IN NORMAL AND POLIOVIRUS-INFECTED HELA CELLS AND THEIR RELATIONSHIP TO MESSENGER-RNA. Proceedings of the National Academy of Sciences of the United States of America. 49: 654-62. PMID 16591084  1
1963 BECKER Y, PENMAN S, DARNELL JE. A CYTOPLASMIC PARTICULATE INVOLVED IN POLIOVIRUS SYNTHESIS. Virology. 21: 274-6. PMID 14070183  0.76
1963 WARNER J, MADDEN MJ, DARNELL JE. The interaction of poliovirus RNA with Escherichia coli ribosomes. Virology. 19: 393-9. PMID 13998949  0.36
1963 SCHERRER K, LATHAM H, DARNELL JE. Demonstration of an unstable RNA and of a precursor to ribosomal RNA in HeLa cells. Proceedings of the National Academy of Sciences of the United States of America. 49: 240-8. PMID 13991616  1
1962 SCHERRER K, DARNELL JE. Sedimentation characteristics of rapidly labelled RNA from HeLa cells. Biochemical and Biophysical Research Communications. 7: 486-90. PMID 14498283  1
1960 DARNELL JE, EAGLE H. The biosynthesis of poliovirus in cell cultures. Advances in Virus Research. 7: 1-26. PMID 13719801 DOI: 10.1016/S0065-3527(08)60004-4  1
1959 DARNELL JE, EAGLE H, SAWYER TK. The effect of cell population density on the amino acid requirements for poliovirus synthesis in HeLa cells. The Journal of Experimental Medicine. 110: 445-50. PMID 13814142  1
1958 DARNELL JE, EAGLE H. Glucose and glutamine in poliovirus production by HeLa cells. Virology. 6: 556-66. PMID 13593191  1
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