| Year |
Citation |
Score |
| 2024 |
Lamantia J, Sloan K, Wallace JM, Roper RJ. Compromised femoral and lumbovertebral bone in the Dp(16)1Yey down syndrome mouse model. Bone. 117046. PMID 38336158 DOI: 10.1016/j.bone.2024.117046 |
0.327 |
|
| 2023 |
Hawley LE, Stringer M, Deal AJ, Folz A, Goodlett CR, Roper RJ. Sex-specific developmental alterations in DYRK1A expression in the brain of a Down syndrome mouse model. Neurobiology of Disease. 190: 106359. PMID 37992782 DOI: 10.1016/j.nbd.2023.106359 |
0.309 |
|
| 2023 |
Sloan K, Thomas J, Blackwell M, Voisard D, Lana-Elola E, Watson-Scales S, Roper DL, Wallace JM, Fisher EMC, Tybulewicz VLJ, Roper RJ. Genetic dissection of triplicated Hsa21 orthologs produces differential skeletal phenotypes in Down syndrome mouse models. Disease Models & Mechanisms. PMID 36939025 DOI: 10.1242/dmm.049927 |
0.389 |
|
| 2022 |
Fulton SL, Wenderski W, Lepack AE, Eagle AL, Fanutza T, Bastle RM, Ramakrishnan A, Hays EC, Neal A, Bendl J, Farrelly LA, Al-Kachak A, Lyu Y, Cetin B, Chan JC, ... ... Roper RJ, et al. Rescue of deficits by Brwd1 copy number restoration in the Ts65Dn mouse model of Down syndrome. Nature Communications. 13: 6384. PMID 36289231 DOI: 10.1038/s41467-022-34200-0 |
0.367 |
|
| 2022 |
Hawley LE, Prochaska F, Stringer M, Goodlett CR, Roper RJ. Sexually dimorphic DYRK1A overexpression on postnatal day 15 in the Ts65Dn mouse model of Down syndrome: Effects of pharmacological targeting on behavioral phenotypes. Pharmacology, Biochemistry, and Behavior. 217: 173404. PMID 35576991 DOI: 10.1016/j.pbb.2022.173404 |
0.306 |
|
| 2021 |
Thomas JR, Sloan K, Cave K, Wallace JM, Roper RJ. Skeletal Deficits in Male and Female down Syndrome Model Mice Arise Independent of Normalized Dyrk1a Expression in Osteoblasts. Genes. 12. PMID 34828335 DOI: 10.3390/genes12111729 |
0.338 |
|
| 2020 |
Roper RJ, Goodlett CR, Martínez de Lagrán M, Dierssen M. Behavioral Phenotyping for Down Syndrome in Mice. Current Protocols in Mouse Biology. 10: e79. PMID 32780566 DOI: 10.1002/Cpmo.79 |
0.349 |
|
| 2020 |
Goodlett CR, Stringer M, LaCombe J, Patel R, Wallace JM, Roper RJ. Evaluation of the therapeutic potential of Epigallocatechin-3-gallate (EGCG) via oral gavage in young adult Down syndrome mice. Scientific Reports. 10: 10426. PMID 32591597 DOI: 10.1038/S41598-020-67133-Z |
0.449 |
|
| 2020 |
Thomas JR, LaCombe J, Long R, Lana-Elola E, Watson-Scales S, Wallace JM, Fisher EMC, Tybulewicz VLJ, Roper RJ. Interaction of sexual dimorphism and gene dosage imbalance in skeletal deficits associated with Down syndrome. Bone. 115367. PMID 32305495 DOI: 10.1016/J.Bone.2020.115367 |
0.416 |
|
| 2020 |
Roper RJ, Hawley L, Goodlett CR. Influence of allelic differences in Down syndrome. Progress in Brain Research. 251: 29-54. PMID 32057311 DOI: 10.1016/Bs.Pbr.2019.09.001 |
0.492 |
|
| 2019 |
LaCombe JM, Roper RJ. Skeletal dynamics of Down syndrome: A developing perspective. Bone. 133: 115215. PMID 31887437 DOI: 10.1016/J.Bone.2019.115215 |
0.333 |
|
| 2019 |
Long R, Drawbaugh ML, Davis CM, Goodlett CR, Williams JR, Roper RJ. Usage of and attitudes about green tea extract and Epigallocathechin-3-gallate (EGCG) as a therapy in individuals with Down syndrome. Complementary Therapies in Medicine. 45: 234-241. PMID 31331567 DOI: 10.1016/J.Ctim.2019.07.002 |
0.307 |
|
| 2019 |
Schill EM, Wright CM, Jamil A, LaCombe JM, Roper RJ, Heuckeroth RO. Down syndrome mouse models have an abnormal enteric nervous system. Jci Insight. 5. PMID 30998504 DOI: 10.1172/Jci.Insight.124510 |
0.408 |
|
| 2017 |
Stringer M, Goodlett CR, Roper RJ. Targeting trisomic treatments: optimizing Dyrk1a inhibition to improve Down syndrome deficits. Molecular Genetics & Genomic Medicine. 5: 451-465. PMID 28944229 DOI: 10.1002/Mgg3.334 |
0.366 |
|
| 2017 |
Stringer M, Abeysekera I, Thomas J, LaCombe J, Stancombe K, Stewart RJ, Dria KJ, Wallace JM, Goodlett CR, Roper RJ. Epigallocatechin-3-gallate (EGCG) consumption in the Ts65Dn model of down syndrome fails to improve behavioral deficits and is detrimental to skeletal phenotypes. Physiology & Behavior. PMID 28478033 DOI: 10.1016/J.Physbeh.2017.05.003 |
0.428 |
|
| 2016 |
McElyea SD, Starbuck JM, Tumbleson-Brink DM, Harrington E, Blazek JD, Ghoneima A, Kula K, Roper RJ. Influence of prenatal EGCG treatment and Dyrk1a dosage reduction on craniofacial features associated with Down syndrome. Human Molecular Genetics. 25: 4856-4869. PMID 28172997 DOI: 10.1093/Hmg/Ddw309 |
0.464 |
|
| 2016 |
McElyea SD, Starbuck JM, Brink DT, Harrington E, Blazek JD, Ghonemia A, Kula K, Roper RJ. Influence of Prenatal EGCG Treatment and Dyrk1a Dosage Reduction on Craniofacial Features Associated with Down Syndrome. Human Molecular Genetics. PMID 27599746 DOI: 10.1093/hmg/ddw309 |
0.389 |
|
| 2016 |
Abeysekera I, Thomas J, Georgiadis TM, Berman AG, Hammond MA, Dria KJ, Wallace JM, Roper RJ. Differential effects of Epigallocatechin-3-gallate containing supplements on correcting skeletal defects in a Down syndrome mouse model. Molecular Nutrition & Food Research. PMID 26748562 DOI: 10.1002/Mnfr.201500781 |
0.495 |
|
| 2015 |
Stringer M, Abeysekera I, Dria KJ, Roper RJ, Goodlett CR. Low dose EGCG treatment beginning in adolescence does not improve cognitive impairment in a Down syndrome mouse model. Pharmacology, Biochemistry, and Behavior. 138: 70-9. PMID 26363314 DOI: 10.1016/J.Pbb.2015.09.002 |
0.386 |
|
| 2015 |
Blazek JD, Abeysekera I, Li J, Roper RJ. Rescue of the abnormal skeletal phenotype in Ts65Dn Down syndrome mice using genetic and therapeutic modulation of trisomic Dyrk1a. Human Molecular Genetics. PMID 26206885 DOI: 10.1093/Hmg/Ddv284 |
0.455 |
|
| 2015 |
Blazek JD, Malik AM, Tischbein M, Arbones ML, Moore CS, Roper RJ. Abnormal mineralization of the Ts65Dn Down syndrome mouse appendicular skeleton begins during embryonic development in a Dyrk1a-independent manner. Mechanisms of Development. 136: 133-42. PMID 25556111 DOI: 10.1016/J.Mod.2014.12.004 |
0.397 |
|
| 2013 |
Billingsley CN, Allen JR, Baumann DD, Deitz SL, Blazek JD, Newbauer A, Darrah A, Long BC, Young B, Clement M, Doerge RW, Roper RJ. Non-trisomic homeobox gene expression during craniofacial development in the Ts65Dn mouse model of Down syndrome. American Journal of Medical Genetics. Part A. 161: 1866-74. PMID 23843306 DOI: 10.1002/Ajmg.A.36006 |
0.414 |
|
| 2013 |
Solzak JP, Liang Y, Zhou FC, Roper RJ. Commonality in Down and fetal alcohol syndromes. Birth Defects Research. Part a, Clinical and Molecular Teratology. 97: 187-97. PMID 23554291 DOI: 10.1002/Bdra.23129 |
0.415 |
|
| 2011 |
Reinholdt LG, Ding Y, Gilbert GJ, Gilbert GT, Czechanski A, Solzak JP, Roper RJ, Johnson MT, Donahue LR, Lutz C, Davisson MT. Molecular characterization of the translocation breakpoints in the Down syndrome mouse model Ts65Dn. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 22: 685-91. PMID 21953412 DOI: 10.1007/S00335-011-9357-Z |
0.519 |
|
| 2011 |
Deitz SL, Roper RJ. Trisomic and allelic differences influence phenotypic variability during development of Down syndrome mice. Genetics. 189: 1487-95. PMID 21926299 DOI: 10.1534/Genetics.111.131391 |
0.511 |
|
| 2011 |
Blazek JD, Gaddy A, Meyer R, Roper RJ, Li J. Disruption of bone development and homeostasis by trisomy in Ts65Dn Down syndrome mice. Bone. 48: 275-80. PMID 20870049 DOI: 10.1016/J.Bone.2010.09.028 |
0.375 |
|
| 2010 |
Blazek JD, Billingsley CN, Newbauer A, Roper RJ. Embryonic and not maternal trisomy causes developmental attenuation in the Ts65Dn mouse model for Down syndrome. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 239: 1645-53. PMID 20503361 DOI: 10.1002/Dvdy.22295 |
0.442 |
|
| 2010 |
Lorenzi H, Duvall N, Cherry SM, Reeves RH, Roper RJ. PCR prescreen for genotyping the Ts65Dn mouse model of Down syndrome. Biotechniques. 48: 35-8. PMID 20095097 DOI: 10.2144/000113342 |
0.496 |
|
| 2009 |
Roper RJ, VanHorn JF, Cain CC, Reeves RH. A neural crest deficit in Down syndrome mice is associated with deficient mitotic response to Sonic hedgehog. Mechanisms of Development. 126: 212-9. PMID 19056491 DOI: 10.1016/J.Mod.2008.11.002 |
0.484 |
|
| 2008 |
Samy ET, Wheeler KM, Roper RJ, Teuscher C, Tung KS. Cutting edge: Autoimmune disease in day 3 thymectomized mice is actively controlled by endogenous disease-specific regulatory T cells. Journal of Immunology (Baltimore, Md. : 1950). 180: 4366-70. PMID 18354156 DOI: 10.4049/Jimmunol.180.7.4366 |
0.384 |
|
| 2007 |
Moore CS, Roper RJ. The power of comparative and developmental studies for mouse models of Down syndrome. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 18: 431-43. PMID 17653795 DOI: 10.1007/S00335-007-9030-8 |
0.49 |
|
| 2007 |
Olson LE, Roper RJ, Sengstaken CL, Peterson EA, Aquino V, Galdzicki Z, Siarey R, Pletnikov M, Moran TH, Reeves RH. Trisomy for the Down syndrome 'critical region' is necessary but not sufficient for brain phenotypes of trisomic mice. Human Molecular Genetics. 16: 774-82. PMID 17339268 DOI: 10.1093/Hmg/Ddm022 |
0.464 |
|
| 2006 |
Roper RJ, Reeves RH. Understanding the basis for Down syndrome phenotypes. Plos Genetics. 2: e50. PMID 16596169 DOI: 10.1371/Journal.Pgen.0020050 |
0.449 |
|
| 2006 |
Roper RJ, Baxter LL, Saran NG, Klinedinst DK, Beachy PA, Reeves RH. Defective cerebellar response to mitogenic Hedgehog signaling in Down [corrected] syndrome mice. Proceedings of the National Academy of Sciences of the United States of America. 103: 1452-6. PMID 16432181 DOI: 10.1073/Pnas.0510750103 |
0.459 |
|
| 2006 |
Roper RJ, St John HK, Philip J, Lawler A, Reeves RH. Perinatal loss of Ts65Dn Down syndrome mice. Genetics. 172: 437-43. PMID 16172497 DOI: 10.1534/Genetics.105.050898 |
0.504 |
|
| 2006 |
Roper RJ, Baxter LL, Saran NG, Klinedinst DK, Beachy PA, Reeves RH. Erratum: Defective cerebellar response to mitogenic Hedgehog signaling in Down's syndrome mice (Proceedings of the National Academy of Sciences of the United States of America (January 31, 2006) 103, 5 (1452-1456) 10.1073/pnas.0510750103)) Proceedings of the National Academy of Sciences of the United States of America. 103. DOI: 10.1073/Pnas.0601630103 |
0.331 |
|
| 2004 |
Olson LE, Roper RJ, Baxter LL, Carlson EJ, Epstein CJ, Reeves RH. Down syndrome mouse models Ts65Dn, Ts1Cje, and Ms1Cje/Ts65Dn exhibit variable severity of cerebellar phenotypes. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 230: 581-9. PMID 15188443 DOI: 10.1002/Dvdy.20079 |
0.497 |
|
| 2003 |
Roper RJ, McAllister RD, Biggins JE, Michael SD, Min SH, Tung KS, Call SB, Gao J, Teuscher C. Aod1 controlling day 3 thymectomy-induced autoimmune ovarian dysgenesis in mice encompasses two linked quantitative trait loci with opposing allelic effects on disease susceptibility. Journal of Immunology (Baltimore, Md. : 1950). 170: 5886-91. PMID 12794114 DOI: 10.4049/Jimmunol.170.12.5886 |
0.448 |
|
| 2003 |
Butterfield RJ, Roper RJ, Rhein DM, Melvold RW, Haynes L, Ma RZ, Doerge RW, Teuscher C. Sex-specific quantitative trait loci govern susceptibility to Theiler's murine encephalomyelitis virus-induced demyelination. Genetics. 163: 1041-6. PMID 12663542 |
0.671 |
|
| 2002 |
Roper RJ, Ma RZ, Biggins JE, Butterfield RJ, Michael SD, Tung KS, Doerge RW, Teuscher C. Interacting quantitative trait loci control loss of peripheral tolerance and susceptibility to autoimmune ovarian dysgenesis after day 3 thymectomy in mice. Journal of Immunology (Baltimore, Md. : 1950). 169: 1640-6. PMID 12133995 DOI: 10.4049/Jimmunol.169.3.1640 |
0.667 |
|
| 2002 |
Potter MR, Rittling SR, Denhardt DT, Roper RJ, Weis JH, Teuscher C, Weis JJ. Role of osteopontin in murine Lyme arthritis and host defense against Borrelia burgdorferi. Infection and Immunity. 70: 1372-81. PMID 11854223 DOI: 10.1128/Iai.70.3.1372-1381.2002 |
0.459 |
|
| 2001 |
Roper RJ, Weis JJ, McCracken BA, Green CB, Ma Y, Weber KS, Fairbairn D, Butterfield RJ, Potter MR, Zachary JF, Doerge RW, Teuscher C. Genetic control of susceptibility to experimental Lyme arthritis is polygenic and exhibits consistent linkage to multiple loci on chromosome 5 in four independent mouse crosses. Genes and Immunity. 2: 388-97. PMID 11704805 DOI: 10.1038/sj.gene.6363801 |
0.663 |
|
| 2000 |
Butterfield RJ, Blankenhorn EP, Roper RJ, Zachary JF, Doerge RW, Teuscher C. Identification of genetic loci controlling the characteristics and severity of brain and spinal cord lesions in experimental allergic encephalomyelitis American Journal of Pathology. 157: 637-645. PMID 10934166 DOI: 10.1016/S0002-9440(10)64574-9 |
0.641 |
|
| 1999 |
Butterfield RJ, Blankenhorn EP, Roper RJ, Zachary JF, Doerge RW, Sudweeks J, Rose J, Teuscher C. Genetic analysis of disease subtypes and sexual dimorphisms in mouse experimental allergic encephalomyelitis (EAE): Relapsing/remitting and monophasic remitting/nonrelapsing EAE are immunogenetically distinct Journal of Immunology. 162: 3096-3102. PMID 10072563 |
0.622 |
|
| 1999 |
Roper RJ, Griffith JS, Lyttle CR, Doerge RW, McNabb AW, Broadbent RE, Teuscher C. Interacting quantitative trait loci control phenotypic variation in murine estradiol-regulated responses Endocrinology. 140: 556-561. PMID 9927277 DOI: 10.1210/Endo.140.2.6521 |
0.394 |
|
| 1999 |
Weis JJ, McCracken BA, Ma Y, Fairbairn D, Roper RJ, Morrison TB, Weis JH, Zachary JF, Doerge RW, Teuscher C. Identification of quantitative trait loci governing arthritis severity and humoral responses in the murine model of Lyme disease Journal of Immunology. 162: 948-956. PMID 9916719 |
0.399 |
|
| 1998 |
Butterfield RJ, Sudweeks JD, Blankenhorn EP, Korngold R, Marini JC, Todd JA, Roper RJ, Teuscher C. New genetic loci that control susceptibility and symptoms of experimental allergic encephalomyelitis in inbred mice Journal of Immunology. 161: 1860-1867. PMID 9712054 |
0.672 |
|
| 1998 |
Roper RJ, Doerge RW, Call SB, Tung KS, Hickey WF, Teuscher C. Autoimmune orchitis, epididymitis, and vasitis are immunogenetically distinct lesions. The American Journal of Pathology. 152: 1337-45. PMID 9588902 |
0.413 |
|
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