| Year |
Citation |
Score |
| 2023 |
Baldwin ET, van Eeuwen T, Hoyos D, Zalevsky A, Tchesnokov EP, Sánchez R, Miller BD, Di Stefano LH, Ruiz FX, Hancock M, Işik E, Mendez-Dorantes C, Walpole T, Nichols C, Wan P, et al. Structures, functions, and adaptations of the human LINE-1 ORF2 protein. Nature. PMID 38096902 DOI: 10.1038/s41586-023-06947-z |
0.312 |
|
| 2023 |
Gidi Y, Robert A, Tordo A, Lovell TC, Ramos-Sanchez J, Sakaya A, Götte M, Cosa G. Binding and Sliding Dynamics of the Hepatitis C Virus Polymerase: Hunting the 3' Terminus. Acs Infectious Diseases. PMID 37436367 DOI: 10.1021/acsinfecdis.3c00048 |
0.484 |
|
| 2023 |
Malone BF, Perry JK, Olinares PDB, Lee HW, Chen J, Appleby TC, Feng JY, Bilello JP, Ng H, Sotiris J, Ebrahim M, Chua EYD, Mendez JH, Eng ET, Landick R, et al. Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature. PMID 36725929 DOI: 10.1038/s41586-022-05664-3 |
0.448 |
|
| 2022 |
Feng JY, Du Pont V, Babusis D, Gordon CJ, Tchesnokov EP, Perry JK, Duong V, Vijjapurapu A, Zhao X, Chan J, Cohen C, Juneja K, Cihlar T, Götte M, Bilello JP. The Nucleoside/Nucleotide Analogs Tenofovir and Emtricitabine Are Inactive against SARS-CoV-2. Molecules (Basel, Switzerland). 27. PMID 35807457 DOI: 10.3390/molecules27134212 |
0.346 |
|
| 2022 |
Stevens LJ, Pruijssers AJ, Lee HW, Gordon CJ, Tchesnokov EP, Gribble J, George AS, Hughes TM, Lu X, Li J, Perry JK, Porter DP, Cihlar T, Sheahan TP, Baric RS, et al. Mutations in the SARS-CoV-2 RNA dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms. Science Translational Medicine. eabo0718. PMID 35482820 DOI: 10.1126/scitranslmed.abo0718 |
0.42 |
|
| 2022 |
Bader CD, Panter F, Garcia R, Tchesnokov EP, Haid S, Walt C, Spröer C, Kiefer AF, Götte M, Overmann J, Pietschmann T, Müller R. Sandacrabins - Structurally Unique Antiviral RNA Polymerase Inhibitors from a Rare Myxobacterium. Chemistry (Weinheim An Der Bergstrasse, Germany). 28: e202104484. PMID 34990513 DOI: 10.1002/chem.202104484 |
0.407 |
|
| 2021 |
Gordon CJ, Lee HW, Tchesnokov EP, Perry JK, Feng JY, Bilello JP, Porter DP, Götte M. Efficient incorporation and template-dependent polymerase inhibition are major determinants for the broad-spectrum antiviral activity of remdesivir. The Journal of Biological Chemistry. 101529. PMID 34953856 DOI: 10.1016/j.jbc.2021.101529 |
0.452 |
|
| 2021 |
Maheden K, Todd B, Gordon CJ, Tchesnokov EP, Götte M. Inhibition of viral RNA-dependent RNA polymerases with clinically relevant nucleotide analogs. The Enzymes. 49: 315-354. PMID 34696837 DOI: 10.1016/bs.enz.2021.07.002 |
0.426 |
|
| 2021 |
Tchesnokov EP, Gordon CJ, Woolner E, Kocincova D, Perry JK, Feng JY, Porter DP, Götte M. Correction: Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action. The Journal of Biological Chemistry. 297: 101048. PMID 34371377 DOI: 10.1016/j.jbc.2021.101048 |
0.395 |
|
| 2021 |
Götte M. Remdesivir for the treatment of Covid-19: the value of biochemical studies. Current Opinion in Virology. 49: 81-85. PMID 34052732 DOI: 10.1016/j.coviro.2021.04.014 |
0.422 |
|
| 2021 |
Gordon CJ, Tchesnokov EP, Schinazi RF, Götte M. Molnupiravir promotes SARS-CoV-2 mutagenesis via the RNA template. The Journal of Biological Chemistry. 100770. PMID 33989635 DOI: 10.1016/j.jbc.2021.100770 |
0.426 |
|
| 2021 |
Todd B, Tchesnokov EP, Götte M. The active form of the influenza cap-snatching endonuclease inhibitor baloxavir marboxil is a tight binding inhibitor. The Journal of Biological Chemistry. 100486. PMID 33647314 DOI: 10.1016/j.jbc.2021.100486 |
0.361 |
|
| 2020 |
Freedman H, Kundu J, Tchesnokov EP, Law JLM, Nieman JA, Schinazi RF, Tyrrell DL, Gotte M, Houghton M. Application of Molecular Dynamics Simulations to the Design of Nucleotide Inhibitors Binding to Norovirus Polymerase. Journal of Chemical Information and Modeling. PMID 33259199 DOI: 10.1021/acs.jcim.0c00742 |
0.333 |
|
| 2020 |
Tchesnokov EP, Gordon CJ, Woolner E, Kocincova D, Perry JK, Feng JY, Porter DP, Gotte M. Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action. The Journal of Biological Chemistry. PMID 32967965 DOI: 10.1074/jbc.AC120.015720 |
0.448 |
|
| 2020 |
Tchesnokov EP, Bailey-Elkin BA, Mark BL, Götte M. Independent inhibition of the polymerase and deubiquitinase activities of the Crimean-Congo Hemorrhagic Fever Virus full-length L-protein. Plos Neglected Tropical Diseases. 14: e0008283. PMID 32497085 DOI: 10.1371/Journal.Pntd.0008283 |
0.465 |
|
| 2020 |
Gordon CJ, Tchesnokov EP, Woolner E, Perry JK, Feng JY, Porter DP, Gotte M. Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency. The Journal of Biological Chemistry. PMID 32284326 DOI: 10.1074/Jbc.Ra120.013679 |
0.544 |
|
| 2020 |
Gordon CJ, Tchesnokov EP, Feng JY, Porter DP, Gotte M. The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus. The Journal of Biological Chemistry. PMID 32094225 DOI: 10.1074/Jbc.Ac120.013056 |
0.526 |
|
| 2019 |
Ablenas C, Gidi Y, Powdrill M, Ahmed N, Shaw T, Mesko M, Götte M, Cosa G, Pezacki JP. Hepatitis C virus helicase binding and activity monitored through site-specific labeling using an expanded genetic code. Acs Infectious Diseases. PMID 31640339 DOI: 10.1021/Acsinfecdis.9B00220 |
0.752 |
|
| 2019 |
Tchesnokov EP, Feng JY, Porter DP, Götte M. Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir. Viruses. 11. PMID 30987343 DOI: 10.3390/V11040326 |
0.547 |
|
| 2018 |
Tchesnokov EP, Raeisimakiani P, Ngure M, Marchant D, Götte M. Recombinant RNA-Dependent RNA Polymerase Complex of Ebola Virus. Scientific Reports. 8: 3970. PMID 29507309 DOI: 10.1038/S41598-018-22328-3 |
0.543 |
|
| 2018 |
Lacbay CM, Menni M, Bernatchez JA, Götte M, Tsantrizos YS. Pharmacophore requirements for HIV-1 reverse transcriptase inhibitors that selectively "Freeze" the pre-translocated complex during the polymerization catalytic cycle. Bioorganic & Medicinal Chemistry. PMID 29478802 DOI: 10.1016/J.Bmc.2018.02.017 |
0.427 |
|
| 2017 |
Vanpouille C, Bernatchez JA, Lisco A, Arakelyan A, Saba E, Götte M, Margolis L. A common anti-cytomegalovirus drug, ganciclovir, inhibits HIV-1 replication in human tissues ex vivo. Aids (London, England). 31: 1519-1528. PMID 28657962 DOI: 10.1097/Qad.0000000000001532 |
0.321 |
|
| 2017 |
Hou S, Kumar A, Xu Z, Airo AM, Stryapunina I, Wong CP, Branton W, Tchesnokov E, Götte M, Power C, Hobman TC. Zika virus hijacks stress granule proteins and modulates the host stress response. Journal of Virology. PMID 28592527 DOI: 10.1128/Jvi.00474-17 |
0.382 |
|
| 2017 |
Balzarini J, Menni M, Das K, van Berckelaer L, Ford A, Maguire NM, Liekens S, Boehmer PE, Arnold E, Götte M, Maguire AR. Guanine α-carboxy nucleoside phosphonate (G-α-CNP) shows a different inhibitory kinetic profile against the DNA polymerases of human immunodeficiency virus (HIV) and herpes viruses. Biochemical Pharmacology. PMID 28390939 DOI: 10.1016/J.Bcp.2017.04.001 |
0.389 |
|
| 2017 |
Gidi Y, Götte M, Cosa G. Conformational Changes Spanning Angstroms to Nanometers via a Combined Protein Induced Fluorescence Enhancement-Förster Resonance Energy Transfer Method. The Journal of Physical Chemistry. B. PMID 28177636 DOI: 10.1021/Acs.Jpcb.6B11495 |
0.373 |
|
| 2017 |
Ablenas CJ, Liu HW, Shkriabai N, Kvaratskhelia M, Cosa G, Götte M. Dynamic Interconversions of HCV Helicase Binding Modes on the Nucleic Acid Substrate. Acs Infectious Diseases. 3: 99-109. PMID 28081608 DOI: 10.1021/Acsinfecdis.6B00177 |
0.474 |
|
| 2016 |
Ngure M, Issur M, Shkriabai N, Liu HW, Cosa G, Kvaratskhelia M, Götte M. Interactions of the Disordered Domain II of Hepatitis C Virus NS5A with Cyclophilin A, NS5B, and viral RNA Show Extensive Overlap. Acs Infectious Diseases. PMID 27676132 DOI: 10.1021/Acsinfecdis.6B00143 |
0.533 |
|
| 2016 |
Götte M, Feld JJ. Direct-acting antiviral agents for hepatitis C: structural and mechanistic insights. Nature Reviews. Gastroenterology & Hepatology. PMID 27147491 DOI: 10.1038/Nrgastro.2016.60 |
0.407 |
|
| 2016 |
Kulkarni AS, Damha MJ, Schinazi RF, Mo H, Doehle B, Sagan SM, Götte M. A complex network of interactions between S282 and G283 of HCV NS5B and the template strand affect susceptibility to Sofosbuvir and Ribavirin. Antimicrobial Agents and Chemotherapy. PMID 26824949 DOI: 10.1128/Aac.02436-15 |
0.492 |
|
| 2015 |
John J, Kim Y, Bennett N, Das K, Liekens S, Naesens L, Arnold E, Maguire AR, Götte M, Dehaen W, Balzarini J. Pronounced Inhibition Shift from HIV Reverse Transcriptase to Herpetic DNA Polymerases by Increasing the Flexibility of α-Carboxy Nucleoside Phosphonates. Journal of Medicinal Chemistry. PMID 26450273 DOI: 10.1021/Acs.Jmedchem.5B01180 |
0.38 |
|
| 2015 |
Yamada K, Wahba AS, Bernatchez JA, Ilina T, Martínez-Montero S, Habibian M, Deleavey GF, Götte M, Parniak MA, Damha MJ. Nucleotide Sugar Pucker Preference Mitigates Excision by HIV-1 RT. Acs Chemical Biology. 10: 2024-33. PMID 26131619 DOI: 10.1021/Acschembio.5B00263 |
0.414 |
|
| 2015 |
Balzarini J, Das K, Bernatchez JA, Martinez SE, Ngure M, Keane S, Ford A, Maguire N, Mullins N, John J, Kim Y, Dehaen W, Vande Voorde J, Liekens S, Naesens L, et al. Alpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimics. Proceedings of the National Academy of Sciences of the United States of America. 112: 3475-80. PMID 25733891 DOI: 10.1073/Pnas.1420233112 |
0.326 |
|
| 2015 |
Piret J, Goyette N, Eckenroth BE, Drouot E, Götte M, Boivin G. Contrasting effects of W781V and W780V mutations in helix N of herpes simplex virus 1 and human cytomegalovirus DNA polymerases on antiviral drug susceptibility. Journal of Virology. 89: 4636-44. PMID 25673718 DOI: 10.1128/Jvi.03360-14 |
0.418 |
|
| 2015 |
Bernatchez JA, Paul R, Tchesnokov EP, Ngure M, Beilhartz GL, Berghuis AM, Lavoie R, Li L, Auger A, Melnyk RA, Grobler JA, Miller MD, Hazuda DJ, Hecht SM, Götte M. Derivatives of mesoxalic acid block translocation of HIV-1 reverse transcriptase. The Journal of Biological Chemistry. 290: 1474-84. PMID 25355312 DOI: 10.1074/Jbc.M114.614305 |
0.428 |
|
| 2014 |
Issur M, Götte M. Resistance patterns associated with HCV NS5A inhibitors provide limited insight into drug binding. Viruses. 6: 4227-41. PMID 25384189 DOI: 10.3390/V6114227 |
0.443 |
|
| 2014 |
Götte M. Resistance to nucleotide analogue inhibitors of hepatitis C virus NS5B: mechanisms and clinical relevance. Current Opinion in Virology. 8: 104-8. PMID 25128987 DOI: 10.1016/J.Coviro.2014.07.010 |
0.517 |
|
| 2014 |
Megens S, De Wit S, Bernatchez J, Dekeersmaeker N, Vinken L, Covens K, Theys K, Camacho RJ, Vandamme AM, Götte M, Van Laethem K. Characterization of amino acids Arg, Ser and Thr at position 70 within HIV-1 reverse transcriptase. Acta Clinica Belgica. 69: 348-57. PMID 25103592 DOI: 10.1179/2295333714Y.0000000038 |
0.393 |
|
| 2014 |
Martínez-Montero S, Deleavey GF, Kulkarni A, Martín-Pintado N, Lindovska P, Thomson M, González C, Götte M, Damha MJ. Rigid 2',4'-difluororibonucleosides: synthesis, conformational analysis, and incorporation into nascent RNA by HCV polymerase. The Journal of Organic Chemistry. 79: 5627-35. PMID 24873952 DOI: 10.1021/Jo500794V |
0.523 |
|
| 2014 |
Beilhartz GL, Ngure M, Johns BA, DeAnda F, Gerondelis P, Götte M. Inhibition of the ribonuclease H activity of HIV-1 reverse transcriptase by GSK5750 correlates with slow enzyme-inhibitor dissociation. The Journal of Biological Chemistry. 289: 16270-7. PMID 24719329 DOI: 10.1074/Jbc.M114.569707 |
0.42 |
|
| 2014 |
Karam P, Powdrill MH, Liu HW, Vasquez C, Mah W, Bernatchez J, Götte M, Cosa G. Dynamics of hepatitis C virus (HCV) RNA-dependent RNA polymerase NS5B in complex with RNA. The Journal of Biological Chemistry. 289: 14399-411. PMID 24692556 DOI: 10.1074/Jbc.M113.529743 |
0.792 |
|
| 2013 |
Ehteshami M, Nijhuis M, Bernatchez JA, Ablenas CJ, McCormick S, de Jong D, Jochmans D, Götte M. Formation of a quaternary complex of HIV-1 reverse transcriptase with a nucleotide-competing inhibitor and its ATP enhancer. The Journal of Biological Chemistry. 288: 17336-46. PMID 23598281 DOI: 10.1074/Jbc.M112.433441 |
0.442 |
|
| 2013 |
Marko RA, Liu HW, Ablenas CJ, Ehteshami M, Götte M, Cosa G. Binding kinetics and affinities of heterodimeric versus homodimeric HIV-1 reverse transcriptase on DNA-DNA substrates at the single-molecule level. The Journal of Physical Chemistry. B. 117: 4560-7. PMID 23305243 DOI: 10.1021/Jp308674G |
0.328 |
|
| 2013 |
Bennett N, Götte M. Utility of the bacteriophage RB69 polymerase gp43 as a surrogate enzyme for herpesvirus orthologs. Viruses. 5: 54-86. PMID 23299784 DOI: 10.3390/V5010054 |
0.381 |
|
| 2012 |
Götte M. The distinct contributions of fitness and genetic barrier to the development of antiviral drug resistance. Current Opinion in Virology. 2: 644-50. PMID 22964133 DOI: 10.1016/J.Coviro.2012.08.004 |
0.338 |
|
| 2012 |
Chatel-Chaix L, Germain MA, Götte M, Lamarre D. Direct-acting and host-targeting HCV inhibitors: current and future directions. Current Opinion in Virology. 2: 588-98. PMID 22959589 DOI: 10.1016/J.Coviro.2012.08.002 |
0.403 |
|
| 2012 |
Scherrer AU, Von Wyl V, Götte M, Klimkait T, Cellerai C, Yerly S, Böni J, Held L, Ledergerber B, Günthard HF. Polymorphic mutations associated with the emergence of the multinucleoside/tide resistance mutations 69 insertion and Q151M Journal of Acquired Immune Deficiency Syndromes. 59: 105-112. PMID 22027876 DOI: 10.1097/Qai.0B013E31823C8B69 |
0.322 |
|
| 2011 |
Powdrill MH, Tchesnokov EP, Kozak RA, Russell RS, Martin R, Svarovskaia ES, Mo H, Kouyos RD, Götte M. Contribution of a mutational bias in hepatitis C virus replication to the genetic barrier in the development of drug resistance. Proceedings of the National Academy of Sciences of the United States of America. 108: 20509-13. PMID 22135458 DOI: 10.1073/Pnas.1105797108 |
0.767 |
|
| 2011 |
Vivet-Boudou V, Isel C, Sleiman M, Smyth R, Ben Gaied N, Barhoum P, Laumond G, Bec G, Götte M, Mak J, Aubertin AM, Burger A, Marquet R. 8-Modified-2'-deoxyadenosine analogues induce delayed polymerization arrest during HIV-1 reverse transcription. Plos One. 6: e27456. PMID 22087320 DOI: 10.1371/Journal.Pone.0027456 |
0.408 |
|
| 2011 |
van Maarseveen NM, Wensing AM, de Jong D, Beilhartz GL, Obikhod A, Tao S, Pingen M, Arends JE, Hoepelman AI, Schinazi RF, Götte M, Nijhuis M. Telbivudine exerts no antiviral activity against HIV-1 in vitro and in humans. Antiviral Therapy. 16: 1123-30. PMID 22024528 DOI: 10.3851/Imp1912 |
0.375 |
|
| 2011 |
Götte M. Initiation of HIV reverse transcription: is enzyme flipping required? Viruses. 3: 331-5. PMID 21994735 DOI: 10.3390/V3040331 |
0.431 |
|
| 2011 |
Auger A, Beilhartz GL, Zhu S, Cauchon E, Falgueyret JP, Grobler JA, Ehteshami M, Götte M, Melnyk RA. Impact of primer-induced conformational dynamics of HIV-1 reverse transcriptase on polymerase translocation and inhibition. The Journal of Biological Chemistry. 286: 29575-83. PMID 21737446 DOI: 10.1074/Jbc.M111.268235 |
0.492 |
|
| 2011 |
Zahn KE, Tchesnokov EP, Götte M, Doublié S. Phosphonoformic acid inhibits viral replication by trapping the closed form of the DNA polymerase. The Journal of Biological Chemistry. 286: 25246-55. PMID 21566148 DOI: 10.1074/Jbc.M111.248864 |
0.407 |
|
| 2011 |
Scarth B, McCormick S, Götte M. Effects of mutations F61A and A62V in the fingers subdomain of HIV-1 reverse transcriptase on the translocational equilibrium. Journal of Molecular Biology. 405: 349-60. PMID 21056575 DOI: 10.1016/J.Jmb.2010.10.009 |
0.452 |
|
| 2011 |
Scarth BJ, Ehteshami M, Beilhartz GL, Götte M. HIV-1 reverse transcriptase inhibitors: beyond classic nucleosides and non-nucleosides Future Virology. 6: 581-598. DOI: 10.2217/Fvl.11.35 |
0.401 |
|
| 2011 |
Karam P, Vasquez C, Mah W, Powdrill M, Aboukhalil R, Götte M, Cosa G. Single Molecule Studies Reveal Sliding Dynamics of Hcv NS5B in Complex with RNA Biophysical Journal. 100: 192a. DOI: 10.1016/J.Bpj.2010.12.1267 |
0.784 |
|
| 2010 |
Beilhartz GL, Götte M. HIV-1 Ribonuclease H: Structure, Catalytic Mechanism and Inhibitors. Viruses. 2: 900-26. PMID 21994660 DOI: 10.3390/V2040900 |
0.377 |
|
| 2010 |
Powdrill MH, Bernatchez JA, Götte M. Inhibitors of the Hepatitis C Virus RNA-Dependent RNA Polymerase NS5B. Viruses. 2: 2169-95. PMID 21994615 DOI: 10.3390/V2102169 |
0.775 |
|
| 2010 |
von Wyl V, Ehteshami M, Demeter LM, Bürgisser P, Nijhuis M, Symons J, Yerly S, Böni J, Klimkait T, Schuurman R, Ledergerber B, Götte M, Günthard HF. HIV-1 reverse transcriptase connection domain mutations: dynamics of emergence and implications for success of combination antiretroviral therapy. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 51: 620-8. PMID 20666602 DOI: 10.1086/655764 |
0.387 |
|
| 2010 |
Chung S, Wendeler M, Rausch JW, Beilhartz G, Gotte M, O'Keefe BR, Bermingham A, Beutler JA, Liu S, Zhuang X, Le Grice SF. Structure-activity analysis of vinylogous urea inhibitors of human immunodeficiency virus-encoded ribonuclease H. Antimicrobial Agents and Chemotherapy. 54: 3913-21. PMID 20547794 DOI: 10.1128/Aac.00434-10 |
0.403 |
|
| 2010 |
Biondi MJ, Beilhartz GL, McCormick S, Götte M. N348I in HIV-1 reverse transcriptase can counteract the nevirapine-mediated bias toward RNase H cleavage during plus-strand initiation. The Journal of Biological Chemistry. 285: 26966-75. PMID 20530477 DOI: 10.1074/Jbc.M110.105775 |
0.437 |
|
| 2010 |
von Wyl V, Ehteshami M, Symons J, Bürgisser P, Nijhuis M, Demeter LM, Yerly S, Böni J, Klimkait T, Schuurman R, Ledergerber B, Götte M, Günthard HF. Epidemiological and biological evidence for a compensatory effect of connection domain mutation N348I on M184V in HIV-1 reverse transcriptase. The Journal of Infectious Diseases. 201: 1054-62. PMID 20170373 DOI: 10.1086/651168 |
0.323 |
|
| 2010 |
Powdrill MH, Deval J, Narjes F, De Francesco R, Götte M. Mechanism of hepatitis C virus RNA polymerase inhibition with dihydroxypyrimidines. Antimicrobial Agents and Chemotherapy. 54: 977-83. PMID 20028820 DOI: 10.1128/Aac.01216-09 |
0.78 |
|
| 2010 |
Götte M, Rausch JW, Marchand B, Sarafianos S, Le Grice SF. Reverse transcriptase in motion: conformational dynamics of enzyme-substrate interactions. Biochimica Et Biophysica Acta. 1804: 1202-12. PMID 19665597 DOI: 10.1016/J.Bbapap.2009.07.020 |
0.489 |
|
| 2010 |
Karam P, Vasquez C, Mah W, Powdrill M, Götte M, Cosa G. Single Molecule Studies on Hcv RNA Polymerase Activity Biophysical Journal. 98: 73a-74a. DOI: 10.1016/J.Bpj.2009.12.416 |
0.785 |
|
| 2010 |
Karam P, Vasquez C, Mah W, Powdrill M, Götte M, Cosa G. Mechanistic Studies at the Single Molecule Level Reveal the Dynamics of HCV Polymerase Protein in Complex with RNA Biophysical Journal. 98: 268a. DOI: 10.1016/J.Bpj.2009.12.1460 |
0.79 |
|
| 2009 |
Tchesnokov EP, Obikhod A, Schinazi RF, Götte M. Engineering of a chimeric RB69 DNA polymerase sensitive to drugs targeting the cytomegalovirus enzyme. The Journal of Biological Chemistry. 284: 26439-46. PMID 19622750 DOI: 10.1074/Jbc.M109.012500 |
0.398 |
|
| 2009 |
Tchesnokov EP, Obikhod A, Massud I, Lisco A, Vanpouille C, Brichacek B, Balzarini J, McGuigan C, Derudas M, Margolis L, Schinazi RF, Götte M. Mechanisms associated with HIV-1 resistance to acyclovir by the V75I mutation in reverse transcriptase. The Journal of Biological Chemistry. 284: 21496-504. PMID 19509419 DOI: 10.1074/Jbc.M109.024026 |
0.443 |
|
| 2009 |
Beilhartz GL, Wendeler M, Baichoo N, Rausch J, Le Grice S, Götte M. HIV-1 reverse transcriptase can simultaneously engage its DNA/RNA substrate at both DNA polymerase and RNase H active sites: implications for RNase H inhibition. Journal of Molecular Biology. 388: 462-74. PMID 19289131 DOI: 10.1016/J.Jmb.2009.03.025 |
0.468 |
|
| 2009 |
Castro C, Smidansky ED, Arnold JJ, Maksimchuk KR, Moustafa I, Uchida A, Götte M, Konigsberg W, Cameron CE. Nucleic acid polymerases use a general acid for nucleotidyl transfer. Nature Structural & Molecular Biology. 16: 212-8. PMID 19151724 DOI: 10.1038/Nsmb.1540 |
0.412 |
|
| 2009 |
Wendeler M, Beilhartz GL, Beutler JA, Götte M, Le Grice SFJ. HIV ribonuclease H: Continuing the search for small molecule antagonists Hiv Therapy. 3: 39-53. DOI: 10.2217/17584310.3.1.39 |
0.38 |
|
| 2008 |
Tchesnokov EP, Obikhod A, Schinazi RF, Götte M. Delayed chain termination protects the anti-hepatitis B virus drug entecavir from excision by HIV-1 reverse transcriptase. The Journal of Biological Chemistry. 283: 34218-28. PMID 18940786 DOI: 10.1074/Jbc.M806797200 |
0.466 |
|
| 2008 |
Dash C, Scarth BJ, Badorrek C, Götte M, Le Grice SFJ. Examining the ribonuclease H primer grip of HIV-1 reverse transcriptase by charge neutralization of RNA/DNA hybrids Nucleic Acids Research. 36: 6363-6371. PMID 18836193 DOI: 10.1093/Nar/Gkn678 |
0.433 |
|
| 2008 |
Wendeler M, Lee HF, Bermingham A, Miller JT, Chertov O, Bona MK, Baichoo NS, Ehteshami M, Beutler J, O'Keefe BR, Götte M, Kvaratskhelia M, Le Grice S. Vinylogous ureas as a novel class of inhibitors of reverse transcriptase-associated ribonuclease H activity. Acs Chemical Biology. 3: 635-44. PMID 18831589 DOI: 10.1021/Cb8001039 |
0.385 |
|
| 2008 |
Lisco A, Vanpouille C, Tchesnokov EP, Grivel JC, Biancotto A, Brichacek B, Elliott J, Fromentin E, Shattock R, Anton P, Gorelick R, Balzarini J, McGuigan C, Derudas M, Götte M, et al. Acyclovir is activated into a HIV-1 reverse transcriptase inhibitor in herpesvirus-infected human tissues. Cell Host & Microbe. 4: 260-70. PMID 18779052 DOI: 10.1016/J.Chom.2008.07.008 |
0.36 |
|
| 2008 |
Ehteshami M, Scarth BJ, Tchesnokov EP, Dash C, Le Grice SF, Hallenberger S, Jochmans D, Götte M. Mutations M184V and Y115F in HIV-1 reverse transcriptase discriminate against "nucleotide-competing reverse transcriptase inhibitors". The Journal of Biological Chemistry. 283: 29904-11. PMID 18728003 DOI: 10.1074/Jbc.M804882200 |
0.445 |
|
| 2008 |
Ehteshami M, Beilhartz GL, Scarth BJ, Tchesnokov EP, McCormick S, Wynhoven B, Harrigan PR, Götte M. Connection domain mutations N348I and A360V in HIV-1 reverse transcriptase enhance resistance to 3'-azido-3'-deoxythymidine through both RNase H-dependent and -independent mechanisms. The Journal of Biological Chemistry. 283: 22222-32. PMID 18547911 DOI: 10.1074/Jbc.M803521200 |
0.423 |
|
| 2007 |
Götte M. Mechanisms of resistance associated with excision of incorporated nucleotide analogue inhibitors of HIV-1 reverse transcriptase. Current Opinion in Hiv and Aids. 2: 103-7. PMID 19372874 DOI: 10.1097/Coh.0B013E3280287A60 |
0.396 |
|
| 2007 |
Götte M. Should we include connection domain mutations of HIV-1 reverse transcriptase in HIV resistance testing. Plos Medicine. 4: e346. PMID 18052605 DOI: 10.1371/Journal.Pmed.0040346 |
0.394 |
|
| 2007 |
Marchand B, White KL, Ly JK, Margot NA, Wang R, McDermott M, Miller MD, Götte M. Effects of the translocation status of human immunodeficiency virus type 1 reverse transcriptase on the efficiency of excision of tenofovir. Antimicrobial Agents and Chemotherapy. 51: 2911-9. PMID 17517852 DOI: 10.1128/Aac.00314-07 |
0.417 |
|
| 2007 |
Deval J, Powdrill MH, D'Abramo CM, Cellai L, Götte M. Pyrophosphorolytic excision of nonobligate chain terminators by hepatitis C virus NS5B polymerase. Antimicrobial Agents and Chemotherapy. 51: 2920-8. PMID 17502402 DOI: 10.1128/Aac.00186-07 |
0.774 |
|
| 2007 |
Deval J, D'Abramo CM, Zhao Z, McCormick S, Coutsinos D, Hess S, Kvaratskhelia M, Götte M. High resolution footprinting of the hepatitis C virus polymerase NS5B in complex with RNA. The Journal of Biological Chemistry. 282: 16907-16. PMID 17449464 DOI: 10.1074/Jbc.M701973200 |
0.547 |
|
| 2007 |
Eggink D, Huigen MC, Boucher CA, Götte M, Nijhuis M. Insertions in the beta3-beta4 loop of reverse transcriptase of human immunodeficiency virus type 1 and their mechanism of action, influence on drug susceptibility and viral replication capacity. Antiviral Research. 75: 93-103. PMID 17416429 DOI: 10.1016/J.Antiviral.2007.03.001 |
0.416 |
|
| 2007 |
Castro C, Smidansky E, Maksimchuk KR, Arnold JJ, Korneeva VS, Götte M, Konigsberg W, Cameron CE. Two proton transfers in the transition state for nucleotidyl transfer catalyzed by RNA- and DNA-dependent RNA and DNA polymerases. Proceedings of the National Academy of Sciences of the United States of America. 104: 4267-72. PMID 17360513 DOI: 10.1073/Pnas.0608952104 |
0.434 |
|
| 2007 |
Klarmann GJ, Eisenhauer BM, Zhang Y, Gotte M, Pata JD, Chatterjee DK, Hecht SM, Le Grice SF. Investigating the "steric gate" of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase by targeted insertion of unnatural amino acids. Biochemistry. 46: 2118-26. PMID 17274599 DOI: 10.1021/Bi061772W |
0.423 |
|
| 2007 |
Marchand B, Tchesnokov EP, Götte M. The pyrophosphate analogue foscarnet traps the pre-translocational state of HIV-1 reverse transcriptase in a Brownian ratchet model of polymerase translocation. The Journal of Biological Chemistry. 282: 3337-46. PMID 17145704 DOI: 10.1074/Jbc.M607710200 |
0.444 |
|
| 2006 |
Jochmans D, Deval J, Kesteleyn B, Van Marck H, Bettens E, De Baere I, Dehertogh P, Ivens T, Van Ginderen M, Van Schoubroeck B, Ehteshami M, Wigerinck P, Götte M, Hertogs K. Indolopyridones inhibit human immunodeficiency virus reverse transcriptase with a novel mechanism of action. Journal of Virology. 80: 12283-92. PMID 17020946 DOI: 10.1128/Jvi.00889-06 |
0.472 |
|
| 2006 |
D'Abramo CM, Deval J, Cameron CE, Cellai L, Götte M. Control of template positioning during de novo initiation of RNA synthesis by the bovine viral diarrhea virus NS5B polymerase. The Journal of Biological Chemistry. 281: 24991-8. PMID 16831816 DOI: 10.1074/Jbc.M600474200 |
0.51 |
|
| 2006 |
Götte M. Effects of nucleotides and nucleotide analogue inhibitors of HIV-1 reverse transcriptase in a ratchet model of polymerase translocation. Current Pharmaceutical Design. 12: 1867-77. PMID 16724953 DOI: 10.2174/138161206776873626 |
0.45 |
|
| 2006 |
Tchesnokov EP, Gilbert C, Boivin G, Götte M. Role of helix P of the human cytomegalovirus DNA polymerase in resistance and hypersusceptibility to the antiviral drug foscarnet. Journal of Virology. 80: 1440-50. PMID 16415021 DOI: 10.1128/Jvi.80.3.1440-1450.2006 |
0.384 |
|
| 2006 |
Götte M, Wainberg MA. Significance of the L74V mutation in HIV-1 reverse transcriptase Future Virology. 1: 493-500. DOI: 10.2217/17460794.1.4.493 |
0.374 |
|
| 2005 |
Frankel FA, Marchand B, Turner D, Götte M, Wainberg MA. Impaired rescue of chain-terminated DNA synthesis associated with the L74V mutation in human immunodeficiency virus type 1 reverse transcriptase. Antimicrobial Agents and Chemotherapy. 49: 2657-64. PMID 15980333 DOI: 10.1128/Aac.49.7.2657-2664.2005 |
0.456 |
|
| 2005 |
Miranda LR, Götte M, Liang F, Kuritzkes DR. The L74V mutation in human immunodeficiency virus type 1 reverse transcriptase counteracts enhanced excision of zidovudine monophosphate associated with thymidine analog resistance mutations. Antimicrobial Agents and Chemotherapy. 49: 2648-56. PMID 15980332 DOI: 10.1128/Aac.49.7.2648-2656.2005 |
0.393 |
|
| 2004 |
Götte M. Inhibition of HIV-1 reverse transcription: basic principles of drug action and resistance. Expert Review of Anti-Infective Therapy. 2: 707-16. PMID 15482234 |
0.319 |
|
| 2004 |
Roldan A, Russell RS, Marchand B, Götte M, Liang C, Wainberg MA. In vitro identification and characterization of an early complex linking HIV-1 genomic RNA recognition and Pr55Gag multimerization. The Journal of Biological Chemistry. 279: 39886-94. PMID 15247214 DOI: 10.1074/Jbc.M405632200 |
0.497 |
|
| 2004 |
Marchand B, Götte M. Impact of the translocational equilibrium of HIV-1 reverse transcriptase on the efficiency of mismatch extensions and the excision of mispaired nucleotides. The International Journal of Biochemistry & Cell Biology. 36: 1823-35. PMID 15183347 DOI: 10.1016/J.Biocel.2004.02.029 |
0.403 |
|
| 2004 |
D'Abramo CM, Cellai L, Götte M. Excision of incorporated nucleotide analogue chain-terminators can diminish their inhibitory effects on viral RNA-dependent RNA polymerases. Journal of Molecular Biology. 337: 1-14. PMID 15001348 DOI: 10.1016/J.Jmb.2004.01.030 |
0.595 |
|
| 2003 |
Diallo K, Götte M, Wainberg MA. Molecular impact of the M184V mutation in human immunodeficiency virus type 1 reverse transcriptase. Antimicrobial Agents and Chemotherapy. 47: 3377-83. PMID 14576091 DOI: 10.1128/Aac.47.11.3377-3383.2003 |
0.466 |
|
| 2003 |
Diallo K, Marchand B, Wei X, Cellai L, Götte M, Wainberg MA. Diminished RNA primer usage associated with the L74V and M184V mutations in the reverse transcriptase of human immunodeficiency virus type 1 provides a possible mechanism for diminished viral replication capacity. Journal of Virology. 77: 8621-32. PMID 12885880 DOI: 10.1128/Jvi.77.16.8621-8632.2003 |
0.533 |
|
| 2003 |
Wei X, Liang C, Götte M, Wainberg MA. Negative effect of the M184V mutation in HIV-1 reverse transcriptase on initiation of viral DNA synthesis. Virology. 311: 202-12. PMID 12832217 DOI: 10.1016/S0042-6822(03)00173-9 |
0.54 |
|
| 2003 |
Diallo K, Brenner B, Oliveira M, Moisi D, Detorio M, Götte M, Wainberg MA. The M184V substitution in human immunodeficiency virus type 1 reverse transcriptase delays the development of resistance to amprenavir and efavirenz in subtype B and C clinical isolates. Antimicrobial Agents and Chemotherapy. 47: 2376-9. PMID 12821504 DOI: 10.1128/Aac.47.7.2376-2379.2003 |
0.406 |
|
| 2003 |
Marchand B, Götte M. Site-specific footprinting reveals differences in the translocation status of HIV-1 reverse transcriptase. Implications for polymerase translocation and drug resistance. The Journal of Biological Chemistry. 278: 35362-72. PMID 12819205 DOI: 10.1074/Jbc.M304262200 |
0.451 |
|
| 2003 |
Girouard M, Diallo K, Marchand B, McCormick S, Götte M. Mutations E44D and V118I in the reverse transcriptase of HIV-1 play distinct mechanistic roles in dual resistance to AZT and 3TC. The Journal of Biological Chemistry. 278: 34403-10. PMID 12819190 DOI: 10.1074/Jbc.M303528200 |
0.4 |
|
| 2003 |
Guo X, Kameoka M, Wei X, Roques B, Gotte M, Liang C, Wainberg MA. Suppression of an intrinsic strand transfer activity of HIV-1 Tat protein by its second-exon sequences. Virology. 307: 154-63. PMID 12667823 DOI: 10.1016/S0042-6822(02)00068-5 |
0.492 |
|
| 2003 |
McLellan N, Wei X, Marchand B, Wainberg MA, Götte M. Nonradioactive detection of retroviral-associated RNase H activity in a microplate-based, high-throughput format. Biotechniques. 33: 424-9. PMID 12188196 DOI: 10.2144/02332Ht03 |
0.402 |
|
| 2002 |
Wei X, Liang C, Götte M, Wainberg MA. The M184V mutation in HIV-1 reverse transcriptase reduces the restoration of wild-type replication by attenuated viruses. Aids (London, England). 16: 2391-8. PMID 12461412 DOI: 10.1097/00002030-200212060-00003 |
0.368 |
|
| 2002 |
Diallo K, Oliveira M, Moisi D, Brenner B, Wainberg MA, Götte M. Pressure of zidovudine accelerates the reversion of lamivudine resistance-conferring M184V mutation in the reverse transcriptase of human immunodeficiency virus type 1. Antimicrobial Agents and Chemotherapy. 46: 2254-6. PMID 12069983 DOI: 10.1128/Aac.46.7.2254-2256.2002 |
0.395 |
|
| 2001 |
Kameoka M, Rong L, Götte M, Liang C, Russell RS, Wainberg MA. Role for human immunodeficiency virus type 1 Tat protein in suppression of viral reverse transcriptase activity during late stages of viral replication. Journal of Virology. 75: 2675-83. PMID 11222691 DOI: 10.1128/Jvi.75.6.2675-2683.2001 |
0.435 |
|
| 2000 |
Götte M, Wainberg MA. Biochemical mechanisms involved in overcoming HIV resistance to nucleoside inhibitors of reverse transcriptase. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 3: 30-38. PMID 11498363 DOI: 10.1054/Drup.2000.0126 |
0.314 |
|
| 2000 |
Götte M, Kameoka M, McLellan N, Cellai L, Wainberg MA. Analysis of efficiency and fidelity of HIV-1 (+)-strand DNA synthesis reveals a novel rate-limiting step during retroviral reverse transcription. The Journal of Biological Chemistry. 276: 6711-9. PMID 11096104 DOI: 10.1074/Jbc.M009097200 |
0.449 |
|
| 2000 |
Wei X, Götte M, Wainberg MA. Human immunodeficiency virus type-1 reverse transcription can be inhibited in vitro by oligonucleotides that target both natural and synthetic tRNA primers Nucleic Acids Research. 28: 3065-3074. PMID 10931921 DOI: 10.1093/Nar/28.16.3065 |
0.544 |
|
| 1999 |
Szyperski T, Götte M, Billeter M, Perola E, Cellai L, Heumann H, Wüthrich K. NMR structure of the chimeric hybrid duplex r(gcaguggc).r(gcca)d(CTGC) comprising the tRNA-DNA junction formed during initiation of HIV-1 reverse transcription. Journal of Biomolecular Nmr. 13: 343-55. PMID 10353196 DOI: 10.1023/A:1008350604637 |
0.473 |
|
| 1998 |
Liang C, Rong L, Götte M, Li X, Quan Y, Kleiman L, Wainberg MA. Mechanistic studies of early pausing events during initiation of HIV-1 reverse transcription. The Journal of Biological Chemistry. 273: 21309-15. PMID 9694891 DOI: 10.1074/Jbc.273.33.21309 |
0.412 |
|
| 1996 |
Götte M, Marquet R, Isel C, Anderson VE, Keith G, Gross HJ, Ehresmann C, Ehresmann B, Heumann H. Probing the higher order structure of RNA with peroxonitrous acid. Febs Letters. 390: 226-8. PMID 8706865 DOI: 10.1016/0014-5793(96)00662-X |
0.371 |
|
| 1995 |
Götte M, Fackler S, Hermann T, Perola E, Cellai L, Gross HJ, Le Grice SF, Heumann H. HIV-1 reverse transcriptase-associated RNase H cleaves RNA/RNA in arrested complexes: implications for the mechanism by which RNase H discriminates between RNA/RNA and RNA/DNA. The Embo Journal. 14: 833-41. PMID 7533725 DOI: 10.1002/J.1460-2075.1995.Tb07061.X |
0.527 |
|
| Show low-probability matches. |