Year |
Citation |
Score |
2012 |
Jain HV, Kalman TI. Synthesis and study of cyclic pronucleotides of 5-fluoro-2'-deoxyuridine. Bioorganic & Medicinal Chemistry Letters. 22: 4497-501. PMID 22738636 DOI: 10.1016/J.Bmcl.2012.06.011 |
0.643 |
|
2010 |
Jain HV, Rasheed R, Kalman TI. The role of phosphate in the action of thymidine phosphorylase inhibitors: Implications for the catalytic mechanism. Bioorganic & Medicinal Chemistry Letters. 20: 1648-51. PMID 20138520 DOI: 10.1016/J.Bmcl.2010.01.076 |
0.669 |
|
2005 |
Kalman TI, Lai L. 6-substituted 5-fluorouracil derivatives as transition state analogue inhibitors of thymidine phosphorylase. Nucleosides, Nucleotides & Nucleic Acids. 24: 367-73. PMID 16247953 DOI: 10.1081/Ncn-200059790 |
0.584 |
|
2004 |
Jiang XJ, Kalman TI. Synthesis of 4-formyl-4-imidazolin-2-one nucleosides, isomers of uridine and 2'-deoxyuridine. Nucleosides, Nucleotides & Nucleic Acids. 23: 307-16. PMID 15043156 DOI: 10.1081/Ncn-120027837 |
0.387 |
|
2003 |
Saxl RL, Reston J, Nie Z, Kalman TI, Maley F. Modification of Escherichia coli thymidylate synthase at tyrosine-94 by 5-imidazolylpropynyl-2'-deoxyuridine 5'-monophosphate. Biochemistry. 42: 4544-51. PMID 12693951 DOI: 10.1021/Bi0268089 |
0.524 |
|
2001 |
Kalman TI, Nie Z, Kamat A. 5-propynylpyrimidine nucleoside derivatives: rationally designed mechanism-based inactivators of thymidylate synthase. Nucleosides, Nucleotides & Nucleic Acids. 20: 869-71. PMID 11563134 DOI: 10.1081/Ncn-100002448 |
0.601 |
|
2000 |
Kalman TI, Nie Z. Rational design of selective antimetabolites of DNA-thymine biosynthesis: 5-propynylpyrimidine nucleoside derivatives. Nucleosides, Nucleotides & Nucleic Acids. 19: 357-69. PMID 10772720 DOI: 10.1080/15257770008033014 |
0.562 |
|
2000 |
Kalman TI, Nie Z, Kamat A. Mechanism-based inactivation of thymidylate synthase by 5-(3-fluoropropyn-1-yl)-2'-deoxyuridine 5'-phosphate. Bioorganic & Medicinal Chemistry Letters. 10: 391-4. PMID 10714507 DOI: 10.1016/S0960-894X(00)00012-3 |
0.582 |
|
1997 |
Ge P, Kalman TI. Design and synthesis of 3,5-dialkylamino substituted 8H,10H-3(R),5(R),15b(S)-2,3,6,7-tetrahydro-1,5,3-dioxazepino[3,2-c]indolo[3,2 -g]pteridine-7-ones Bioorganic and Medicinal Chemistry Letters. 7: 3023-3026. DOI: 10.1016/S0960-894X(97)10138-X |
0.331 |
|
1996 |
McGuire JJ, Tsukamoto T, Hart BP, Coward JK, Kalman TI, Galivan J. Exploitation of folate and antifolate polyglutamylation to achieve selective anticancer chemotherapy. Investigational New Drugs. 14: 317-23. PMID 8958187 DOI: 10.1007/Bf00194535 |
0.39 |
|
1996 |
Abraham TW, Kalman TI, McIntee EJ, Wagner CR. Synthesis and biological activity of aromatic amino acid phosphoramidates of 5-fluoro-2'-deoxyuridine and 1-beta-arabinofuranosylcytosine: evidence of phosphoramidase activity. Journal of Medicinal Chemistry. 39: 4569-75. PMID 8917645 DOI: 10.1021/Jm9603680 |
0.348 |
|
1996 |
Mao Z, Pan J, Kalman TI. Design and synthesis of histidine analogues of folic acid and methotrexate as potential folylpolyglutamate synthetase inhibitors Journal of Medicinal Chemistry. 39: 4340-4344. PMID 8863812 DOI: 10.1021/Jm960250J |
0.434 |
|
1996 |
Ge P, Voronin GO, Kalman TI. Synthesis and structure determination of a nucleoside-derived new heterocyclic system: 8H, 10H, 15b(S)-2,3,6,7-tetrahydro-1,5,3- dioxazepino[3,2-c]indolo[3,2-g]pteridine-7-one Nucleosides and Nucleotides. 15: 1701-1710. DOI: 10.1080/07328319608002725 |
0.308 |
|
1994 |
Kerr SG, Kalman TI. N4-(dialkylamino)methylene derivatives of 2'-deoxycytidine and arabinocytidine: physicochemical studies for potential prodrug applications. Journal of Pharmaceutical Sciences. 83: 582-6. PMID 8046619 DOI: 10.1002/Jps.2600830428 |
0.407 |
|
1994 |
Jiang XJ, Kalman TI. Synthesis of a novel antiretroviral thymidine analog: 1-(2-deoxy-β-D- ribofuranosyl)-4-acetylimidazolin-2-one (imidine) Nucleosides and Nucleotides. 13: 379-388. DOI: 10.1080/15257779408013248 |
0.346 |
|
1993 |
Cody V, Wojtczak A, Kalman TI, Friesheim JH, Blakley RL. Conformational analysis of human dihydrofolate reductase inhibitor complexes: Crystal structure determination of wild type and F31 mutant binary and ternary inhibitor complexes Advances in Experimental Medicine and Biology. 338: 481-486. PMID 8304163 DOI: 10.1007/978-1-4615-2960-6_97 |
0.302 |
|
1993 |
Kalman TI. Mechanism-based approaches to inhibition of the synthesis and degradation of folate and antifolate polyglutamates. Advances in Experimental Medicine and Biology. 338: 639-43. PMID 7508172 DOI: 10.1007/978-1-4615-2960-6_132 |
0.37 |
|
1992 |
Harvison PJ, Kalman TI. Synthesis and biological activity of novel folic acid analogues: pteroyl-S-alkylhomocysteine sulfoximines. Journal of Medicinal Chemistry. 35: 1227-33. PMID 1560436 DOI: 10.1021/Jm00085A010 |
0.397 |
|
1992 |
Kerr SG, Kalman TI. Highly water-soluble lipophilic prodrugs of the anti-HIV nucleoside analogue 2′,3′-dideoxycytidine and its 3′-fluoro derivative Journal of Medicinal Chemistry. 35: 1996-2001. PMID 1317921 DOI: 10.1021/Jm00089A008 |
0.335 |
|
1992 |
Cody V, Kalman TI. Conformational analysis of two anti-hiv nucleoside analogues 2',3'-dideoxy-3'-fluorocytidine and its n4-dimethylaminomethylene prodrug derivative Nucleosides and Nucleotides. 11: 731-738. DOI: 10.1080/07328319208021737 |
0.31 |
|
1991 |
Kalman TI, Marinelli ER, Xu B, Reddy AR, Johnson F, Grollman AP. Inhibition of cellular thymidylate synthesis by cytotoxic propenal derivatives of pyrimidine bases and deoxynucleosides. Biochemical Pharmacology. 42: 431-7. PMID 1713460 DOI: 10.1016/0006-2952(91)90732-K |
0.376 |
|
1989 |
Kalman TI, Houston DM. Novel Acyclic Derivatives Of Aica-Riboside (1-(β-D-Ribofuranosyl)5-Amino-4-Ihidazolecarboxamide), Potential Antiviral Agents Nucleosides and Nucleotides. 8: 899-902. DOI: 10.1080/07328318908054240 |
0.315 |
|
1988 |
Moran RG, Colman PD, Harvison PJ, Kalman TI. Evaluation of pteroyl-S-alkylhomocysteine sulfoximines as inhibitors of mammalian folylpolyglutamate synthetase Biochemical Pharmacology. 37: 1997-2003. PMID 3377808 DOI: 10.1016/0006-2952(88)90547-3 |
0.447 |
|
1987 |
Nair MG, Dhawan R, Ghazala M, Kalman TI, Ferone R, Gaumont Y, Kisliuk RL. Folate analogues. 30. Synthesis and biological evaluation of N10-propargyl-5,8-dideaza-5,6,7,8-tetrahydrofolic acid and related compounds. Journal of Medicinal Chemistry. 30: 1256-61. PMID 3599032 DOI: 10.1021/Jm00390A025 |
0.418 |
|
1987 |
Whitehead VM, Kalman TI, Vuchich MJ. Inhibition of gamma-glutamyl hydrolases in human cells by 2-mercaptomethylglutaric acid. Biochemical and Biophysical Research Communications. 144: 292-7. PMID 2437910 DOI: 10.1016/S0006-291X(87)80509-0 |
0.337 |
|
1986 |
Ghazala M, Nair MG, Toghiyani TR, Kisliuk RL, Gaumont Y, Kalman TI. Folate analogues. 25. Synthesis and biological evaluation of N10-propargylfolic acid and Its reduced derivatives Journal of Medicinal Chemistry. 29: 1263-1269. PMID 3100797 DOI: 10.1021/Jm00157A600 |
0.373 |
|
1986 |
Nair MG, Nanavati NT, Nair IG, Kisliuk RL, Gaumont Y, Hsiao MC, Kalman TI. Folate analogues. 26. Syntheses and antifolate activity of 10-substituted derivatives of 5,8-dideazafolic acid and of the poly-gamma-glutamyl metabolites of N10-propargyl-5,8-dideazafolic acid (PDDF). Journal of Medicinal Chemistry. 29: 1754-60. PMID 3091832 DOI: 10.1021/Jm00159A032 |
0.396 |
|
1986 |
Schinazi RF, Arbiser J, Lee JJS, Kalman TI, Prusoff WH. Synthesis and biological activity of 5-phenylselenenyl-substituted pyrimidine nucleosides Journal of Medicinal Chemistry. 29: 1293-1295. PMID 3027329 DOI: 10.1002/Chin.198648339 |
0.444 |
|
1986 |
Ghazala M, Nair MG, Toghiyani TR, Kisliuk RL, Gaumont Y, Kalman TI. Folate Analogues. Part 25. Synthesis and Biological Evaluation of N10-Propargylfolic Acid and Its Reduced Derivatives. Cheminform. 17. DOI: 10.1002/Chin.198648341 |
0.342 |
|
1985 |
Yalowich JC, Kalman TI. Rapid determination of thymidylate synthase activity and its inhibition in intact L1210 leukemia cells in vitro. Biochemical Pharmacology. 34: 2319-24. PMID 3160352 DOI: 10.1016/0006-2952(85)90788-9 |
0.334 |
|
1984 |
Gangjee A, O'Donnell JK, Bardos TJ, Kalman TI. Synthesis of some 1,3,8-trisubstituted pyrimido[4,5-c][2,7]-naphthyridin-6-ones as potential antitumor agents Journal of Heterocyclic Chemistry. 21: 873-875. DOI: 10.1002/Jhet.5570210347 |
0.356 |
|
1983 |
Goldman D, Kalman TI. Formation of 5- and 6-Aminocytosine Nucleosides and Nucleotides from the Corresponding 5-Bromocytosine Derivatives: Synthesis and Reaction Mechanism Nucleosides and Nucleotides. 2: 175-187. DOI: 10.1080/07328318308081257 |
0.34 |
|
1982 |
Gangjee A, Kalman TI, Bardos TJ. Diazoketone and chloromethylketone analogs of methotrexate as potential antitumor agents. Journal of Pharmaceutical Sciences. 71: 717-9. PMID 7097545 DOI: 10.1002/Chin.198247239 |
0.385 |
|
1981 |
Kalman TI, Goldman D. Inactivation of thymidylate synthetase by a novel mechanism-based enzyme inhibitor: 1-(beta-D-2'-deoxyribofuranosyl) 8-azapurin-2-one 5'-monophosphate. Biochemical and Biophysical Research Communications. 102: 682-9. PMID 6796091 DOI: 10.1016/S0006-291X(81)80186-6 |
0.378 |
|
1981 |
Kalman TI. Enzyme inhibition as a source of new drugs Drug Development Research. 1: 311-328. DOI: 10.1002/Ddr.430010404 |
0.391 |
|
1979 |
Choi S, Kalman TI, Bardos TJ. Synthesis of 5-selenium-substituted uracil derivatives. Inhibition of thymidylate synthetase by 5-hydroseleno-2'-deoxyuridylate. Journal of Medicinal Chemistry. 22: 618-21. PMID 110931 |
0.329 |
|
1975 |
Bardos TJ, Aradi J, Ho YK, Kalman TI. Biochemical properties of 5-sulfur-substituted pyrimidine nucleosides and nucleotides. Annals of the New York Academy of Sciences. 255: 522-31. PMID 1059371 DOI: 10.1111/J.1749-6632.1975.Tb29255.X |
0.319 |
|
1973 |
Kalman TI, Bloch A, Szekeres GL, Bardos TJ. Methylation of 4-thio-2′-deoxyuridylate by thymidylate synthetase Biochemical and Biophysical Research Communications. 55: 210-217. PMID 4205909 DOI: 10.1016/S0006-291X(73)80081-6 |
0.368 |
|
1972 |
Kalman TI. Enzymatic synthesis of 2′-deoxypseudouridylic acid Biochemical and Biophysical Research Communications. 46: 1194-1200. PMID 5062424 DOI: 10.1016/S0006-291X(72)80101-3 |
0.364 |
|
1972 |
Kalman TI. Inhibition of thymidylate synthetase by showdomycin and its 5′-phosphate Biochemical and Biophysical Research Communications. 49: 1007-1013. PMID 4629808 DOI: 10.1016/0006-291X(72)90312-9 |
0.395 |
|
1971 |
Kalman TI. Glutathione-catalyzed hydrogen isotope exchange at position 5 of uridine. A model for enzymic carbon alkylation reactions of pyrimidines. Biochemistry. 10: 2567-73. PMID 5557802 DOI: 10.1021/Bi00789A024 |
0.311 |
|
1970 |
Szabo L, Kalman TI, Bardos TJ. The reaction of 5-bromouracil derivatives with sulfur nucleophiles, and a novel synthetic route to 5-sulfur-substituted uracils and nucleotides. The Journal of Organic Chemistry. 35: 1434-7. PMID 5440334 DOI: 10.1021/Jo00830A038 |
0.34 |
|
1970 |
Kotick MP, Kalman TI, Bardos TJ. Synthesis and thiolytic cleavage of S-acyl derivatives of 5-mercaptouracil and 5-mercapto-2'-deoxyuridine. Journal of Medicinal Chemistry. 13: 74-7. PMID 5412119 DOI: 10.1021/Jm00295A019 |
0.364 |
|
1969 |
Baranski K, Bardos TJ, Bloch A, Kalman TI. 5-mercaptodeoxyuridine--its enzymatic synthesis and mode of action in microbiological systems. Biochemical Pharmacology. 18: 347-58. PMID 4976026 DOI: 10.1016/0006-2952(69)90212-3 |
0.385 |
|
1966 |
Bardos TJ, Kalman TI. Spectrophotometric and chemical studies of 5-mercaptouracil, 5-mercaptodeoxyuridine, and their S-substituted derivatives. Journal of Pharmaceutical Sciences. 55: 606-10. PMID 5924125 DOI: 10.1002/Jps.2600550615 |
0.328 |
|
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