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Greg Hussack, Ph.D. - Publications

Affiliations: 
2011 Biochemistry, Microbiology and Immunology University of Ottawa, Ottawa, ON, Canada 
Area:
Microbiology Biology, Immunology, Toxicology
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47 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Aguilar EN, Sagar S, Murray BR, Rajesh C, Lei EK, Michaud SA, Goodlett DR, Caffrey TC, Grandgenett PM, Swanson B, Brooks TM, Black AR, van Faassen H, Hussack G, Henry KA, et al. Structural Basis for Multivalent MUC16 Recognition and Robust Anti-Pancreatic Cancer Activity of Humanized Antibody AR9.6. Molecular Cancer Therapeutics. PMID 38394685 DOI: 10.1158/1535-7163.MCT-23-0868  0.481
2023 Kim DY, Kandalaft H, Lowden MJ, Yang Q, Rossotti MA, Robotham A, Kelly JF, Hussack G, Schrag JD, Henry KA, Tanha J. Sequence tolerance of immunoglobulin variable domain framework regions to non-canonical intradomain disulfide linkages. The Journal of Biological Chemistry. 105278. PMID 37742917 DOI: 10.1016/j.jbc.2023.105278  0.662
2023 Lowden MJ, Lei EK, Hussack G, Henry KA. Applications of High-Throughput DNA Sequencing to Single-Domain Antibody Discovery and Engineering. Methods in Molecular Biology (Clifton, N.J.). 2702: 489-540. PMID 37679637 DOI: 10.1007/978-1-0716-3381-6_26  0.43
2023 Rossotti MA, Trempe F, van Faassen H, Hussack G, Arbabi-Ghahroudi M. Isolation and Characterization of Single-Domain Antibodies from Immune Phage Display Libraries. Methods in Molecular Biology (Clifton, N.J.). 2702: 107-147. PMID 37679618 DOI: 10.1007/978-1-0716-3381-6_7  0.451
2023 Lei EK, Ryan S, van Faassen H, Foss M, Robotham A, Baltat I, Fulton K, Henry KA, Chen W, Hussack G. Isolation and characterization of a VHH targeting the Acinetobacter baumannii cell surface protein CsuA/B. Applied Microbiology and Biotechnology. 1-14. PMID 37284893 DOI: 10.1007/s00253-023-12594-1  0.361
2023 Hussack G, Rossotti MA, van Faassen H, Murase T, Eugenio L, Schrag JD, Ng KK, Tanha J. Corrigendum: Structure-guided design of a potent toxin A inhibitor. Frontiers in Microbiology. 14: 1167817. PMID 37065148 DOI: 10.3389/fmicb.2023.1167817  0.521
2023 Hussack G, Rossotti MA, van Faassen H, Murase T, Eugenio L, Schrag JD, Ng KK, Tanha J. Structure-guided design of a potent toxin A inhibitor. Frontiers in Microbiology. 14: 1110541. PMID 36778856 DOI: 10.3389/fmicb.2023.1110541  0.571
2022 Sheff J, Kelly J, Foss M, Brunette E, Kemmerich K, van Faassen H, Raphael S, Hussack G, Comamala G, Rand K, Stanimirovic DB. Epitope mapping of a blood-brain barrier crossing antibody targeting the cysteine-rich region of IGF1R using hydrogen-exchange mass spectrometry enabled by electrochemical reduction. Journal of Biochemistry. PMID 36346120 DOI: 10.1093/jb/mvac088  0.376
2022 Rossotti MA, van Faassen H, Tran AT, Sheff J, Sandhu JK, Duque D, Hewitt M, Wen X, Bavananthasivam J, Beitari S, Matte K, Laroche G, Giguère PM, Gervais C, Stuible M, ... ... Hussack G, et al. Arsenal of nanobodies shows broad-spectrum neutralization against SARS-CoV-2 variants of concern in vitro and in vivo in hamster models. Communications Biology. 5: 933. PMID 36085335 DOI: 10.1038/s42003-022-03866-z  0.7
2022 Yogi A, Hussack G, van Faassen H, Haqqani AS, Delaney CE, Brunette E, Sandhu JK, Hewitt M, Sulea T, Kemmerich K, Stanimirovic DB. Brain Delivery of IGF1R5, a Single-Domain Antibody Targeting Insulin-like Growth Factor-1 Receptor. Pharmaceutics. 14. PMID 35890347 DOI: 10.3390/pharmaceutics14071452  0.337
2022 Cairns CM, Michael FS, Jamshidi M, van Faassen H, Yang Q, Henry KA, Hussack G, Sauvageau J, Vinogradov EV, Cox AD. Structural Characterization and Evaluation of an Epitope at the Tip of the A-Band Rhamnan Polysaccharide of . Acs Infectious Diseases. PMID 35653593 DOI: 10.1021/acsinfecdis.2c00183  0.389
2022 Lowden MJ, van Faassen H, Raphael S, Ryan S, Hussack G, Henry KA. Facile Affinity Maturation of Single-Domain Antibodies Using Next-Generation DNA Sequencing. Methods in Molecular Biology (Clifton, N.J.). 2446: 245-268. PMID 35157277 DOI: 10.1007/978-1-0716-2075-5_12  0.431
2021 Henry KA, Nguyen TD, Baral TN, Hussack G, Raphael S, Arbabi-Ghahroudi M, Robert A, Durocher Y, Wu C, Jaramillo ML, MacKenzie CR. Biparatopic single-domain antibodies against Axl achieve ultra-high affinity through intramolecular engagement. Biochemical and Biophysical Research Communications. 562: 154-161. PMID 34058562 DOI: 10.1016/j.bbrc.2021.05.030  0.489
2021 van Faassen H, Jo DH, Ryan S, Lowden MJ, Raphael S, MacKenzie CR, Lee SH, Hussack G, Henry KA. Incorporation of a Novel CD16-Specific Single-Domain Antibody into Multispecific Natural Killer Cell Engagers With Potent ADCC. Molecular Pharmaceutics. PMID 33999642 DOI: 10.1021/acs.molpharmaceut.1c00208  0.302
2020 van Faassen H, Ryan S, Henry KA, Raphael S, Yang Q, Rossotti MA, Brunette E, Jiang S, Haqqani AS, Sulea T, MacKenzie CR, Tanha J, Hussack G. Serum albumin-binding V Hs with variable pH sensitivities enable tailored half-life extension of biologics. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32342547 DOI: 10.1096/Fj.201903231R  0.666
2020 Cairns CM, van Faassen H, St Michael F, Aubry A, Henry KA, Rossotti MA, Logan SM, Hussack G, Gisch N, Hogendorf WF, Pedersen CM, Cox AD. Development and characterisation of mouse monoclonal antibodies specific for Clostridiodes (Clostridium) difficile lipoteichoic acid. Acs Chemical Biology. PMID 32191024 DOI: 10.1021/Acschembio.0C00066  0.557
2020 Richard G, MacKenzie CR, Henry KA, Vinogradov E, Hall JC, Hussack G. Antibody Binding to the O-Specific Antigen of O6 Inhibits Cell Growth. Antimicrobial Agents and Chemotherapy. PMID 32015038 DOI: 10.1128/AAC.02168-19  0.379
2019 Henry KA, Hussack G, Kumaran J, Gilbert M, MacKenzie CR, Sulea T, Arbabi-Ghahroudi M. Role of the non-hypervariable FR3 D-E loop in single-domain antibody recognition of haptens and carbohydrates. Journal of Molecular Recognition : Jmr. e2805. PMID 31423671 DOI: 10.1002/Jmr.2805  0.579
2019 Togtema M, Hussack G, Dayer G, Teghtmeyer MR, Raphael S, Tanha J, Zehbe I. Single-Domain Antibodies Represent Novel Alternatives to Monoclonal Antibodies as Targeting Agents against the Human Papillomavirus 16 E6 Protein. International Journal of Molecular Sciences. 20. PMID 31035322 DOI: 10.3390/Ijms20092088  0.711
2019 Kim DY, Kandalaft H, Hussack G, Raphael S, Ding W, Kelly JF, Henry KA, Tanha J. Evaluation of a non-canonical Cys40-Cys55 disulfide linkage for stabilization of single-domain antibodies. Protein Science : a Publication of the Protein Society. PMID 30803088 DOI: 10.1002/Pro.3595  0.715
2019 D'Eall C, Pon RA, Rossotti MA, Krahn N, Spearman M, Callaghan D, van Faassen H, Hussack G, Stetefeld J, Butler M, Durocher Y, Zhang J, Henry KA, Tanha J. Modulation of antibody-dependent cellular cytotoxicity of EGFR-specific heavy-chain antibodies through hinge engineering. Immunology and Cell Biology. PMID 30680791 DOI: 10.1111/Imcb.12238  0.739
2019 Rossotti MA, Henry KA, van Faassen H, Tanha J, Callaghan D, Hussack G, Arbabi-Ghahroudi M, MacKenzie CR. Camelid single-domain antibodies raised by DNA immunization are potent inhibitors of EGFR signaling. The Biochemical Journal. 476: 39-50. PMID 30455372 DOI: 10.1042/Bcj20180795  0.69
2018 Hussack G, Ryan S, van Faassen H, Rossotti M, MacKenzie CR, Tanha J. Neutralization of Clostridium difficile toxin B with VHH-Fc fusions targeting the delivery and CROPs domains. Plos One. 13: e0208978. PMID 30540857 DOI: 10.1371/Journal.Pone.0208978  0.711
2018 Hussack G, Raphael S, Lowden MJ, Henry KA. Isolation and characterization of camelid single-domain antibodies against HER2. Bmc Research Notes. 11: 866. PMID 30518413 DOI: 10.1186/S13104-018-3955-8  0.552
2018 Sulea T, Hussack G, Ryan S, Tanha J, Purisima EO. Application of Assisted Design of Antibody and Protein Therapeutics (ADAPT) improves efficacy of a Clostridium difficile toxin A single-domain antibody. Scientific Reports. 8: 2260. PMID 29396522 DOI: 10.1038/S41598-018-20599-4  0.73
2017 Henry KA, Kim DY, Kandalaft H, Lowden MJ, Yang Q, Schrag JD, Hussack G, MacKenzie CR, Tanha J. Stability-Diversity Tradeoffs Impose Fundamental Constraints on Selection of Synthetic Human VH/VL Single-Domain Antibodies from In Vitro Display Libraries. Frontiers in Immunology. 8: 1759. PMID 29375542 DOI: 10.3389/Fimmu.2017.01759  0.731
2017 Hussack G, Baral TN, Baardsnes J, van Faassen H, Raphael S, Henry KA, Zhang J, MacKenzie CR. A Novel Affinity Tag, ABTAG, and Its Application to the Affinity Screening of Single-Domain Antibodies Selected by Phage Display. Frontiers in Immunology. 8: 1406. PMID 29163485 DOI: 10.3389/Fimmu.2017.01406  0.505
2017 Henry KA, Kandalaft H, Lowden MJ, Rossotti MA, van Faassen H, Hussack G, Durocher Y, Kim DY, Tanha J. A disulfide-stabilized human VL single-domain antibody library is a source of soluble and highly thermostable binders. Molecular Immunology. 90: 190-196. PMID 28820969 DOI: 10.1016/J.Molimm.2017.07.006  0.747
2016 Henry KA, Sulea T, van Faassen H, Hussack G, Purisima EO, MacKenzie CR, Arbabi-Ghahroudi M. A Rational Engineering Strategy for Designing Protein A-Binding Camelid Single-Domain Antibodies. Plos One. 11: e0163113. PMID 27631624 DOI: 10.1371/Journal.Pone.0163113  0.527
2016 Henry KA, Hussack G, Collins C, Zwaagstra JC, Tanha J, MacKenzie CR. Isolation of TGF-β-neutralizing single-domain antibodies of predetermined epitope specificity using next-generation DNA sequencing. Protein Engineering, Design & Selection : Peds. PMID 27613412 DOI: 10.1093/Protein/Gzw043  0.682
2016 Hussack G, Tanha J. An update on antibody-based immunotherapies for Clostridium difficile infection. Clinical and Experimental Gastroenterology. 9: 209-24. PMID 27536153 DOI: 10.2147/Ceg.S84017  0.702
2015 Henry KA, Tanha J, Hussack G. Identification of cross-reactive single-domain antibodies against serum albumin using next-generation DNA sequencing. Protein Engineering, Design & Selection : Peds. 28: 379-83. PMID 26319004 DOI: 10.1093/Protein/Gzv039  0.703
2015 Kandalaft H, Hussack G, Aubry A, van Faassen H, Guan Y, Arbabi-Ghahroudi M, MacKenzie R, Logan SM, Tanha J. Targeting surface-layer proteins with single-domain antibodies: a potential therapeutic approach against Clostridium difficile-associated disease. Applied Microbiology and Biotechnology. PMID 25936376 DOI: 10.1007/S00253-015-6594-1  0.725
2014 Kim DY, Hussack G, Kandalaft H, Tanha J. Mutational approaches to improve the biophysical properties of human single-domain antibodies. Biochimica Et Biophysica Acta. 1844: 1983-2001. PMID 25065345 DOI: 10.1016/J.Bbapap.2014.07.008  0.74
2014 Hussack G, Riazi A, Ryan S, van Faassen H, MacKenzie R, Tanha J, Arbabi-Ghahroudi M. Protease-resistant single-domain antibodies inhibit Campylobacter jejuni motility. Protein Engineering, Design & Selection : Peds. 27: 191-8. PMID 24742504 DOI: 10.1093/Protein/Gzu011  0.697
2014 Murase T, Eugenio L, Schorr M, Hussack G, Tanha J, Kitova EN, Klassen JS, Ng KK. Structural basis for antibody recognition in the receptor-binding domains of toxins A and B from Clostridium difficile. The Journal of Biological Chemistry. 289: 2331-43. PMID 24311789 DOI: 10.1074/Jbc.M113.505917  0.706
2012 Hussack G, Mackenzie CR, Tanha J. Characterization of single-domain antibodies with an engineered disulfide bond. Methods in Molecular Biology (Clifton, N.J.). 911: 417-29. PMID 22886266 DOI: 10.1007/978-1-61779-968-6_25  0.71
2012 Hussack G, Arbabi-Ghahroudi M, Mackenzie CR, Tanha J. Isolation and characterization of Clostridium difficile toxin-specific single-domain antibodies. Methods in Molecular Biology (Clifton, N.J.). 911: 211-39. PMID 22886255 DOI: 10.1007/978-1-61779-968-6_14  0.743
2012 Aubry A, Hussack G, Chen W, KuoLee R, Twine SM, Fulton KM, Foote S, Carrillo CD, Tanha J, Logan SM. Modulation of toxin production by the flagellar regulon in Clostridium difficile. Infection and Immunity. 80: 3521-32. PMID 22851750 DOI: 10.1128/Iai.00224-12  0.586
2012 Hussack G, Keklikian A, Alsughayyir J, Hanifi-Moghaddam P, Arbabi-Ghahroudi M, van Faassen H, Hou ST, Sad S, MacKenzie R, Tanha J. A V(L) single-domain antibody library shows a high-propensity to yield non-aggregating binders. Protein Engineering, Design & Selection : Peds. 25: 313-8. PMID 22490957 DOI: 10.1093/Protein/Gzs014  0.62
2012 Parisien A, Al-Zarka F, Hussack G, Baranova EA, Thibault J, Qingdao Lan C. Nickel nanoparticles synthesized by a modified polyol method for the purification of histidine-tagged single-domain antibody ToxA5.1 Journal of Materials Research. 27: 2884-2890. DOI: 10.1557/Jmr.2012.323  0.371
2011 Hussack G, Hirama T, Ding W, Mackenzie R, Tanha J. Engineered single-domain antibodies with high protease resistance and thermal stability. Plos One. 6: e28218. PMID 22140551 DOI: 10.1371/Journal.Pone.0028218  0.644
2011 Hussack G, Arbabi-Ghahroudi M, van Faassen H, Songer JG, Ng KK, MacKenzie R, Tanha J. Neutralization of Clostridium difficile toxin A with single-domain antibodies targeting the cell receptor binding domain. The Journal of Biological Chemistry. 286: 8961-76. PMID 21216961 DOI: 10.1074/Jbc.M110.198754  0.716
2010 Hussack G, Tanha J. Toxin-specific antibodies for the treatment of Clostridium difficile: current status and future perspectives. Toxins. 2: 998-1018. PMID 22069622 DOI: 10.3390/Toxins2050998  0.7
2010 Hussack G, Grohs BM, Almquist KC, McLean MD, Ghosh R, Hall JC. Purification of plant-derived antibodies through direct immobilization of affinity ligands on cellulose. Journal of Agricultural and Food Chemistry. 58: 3451-9. PMID 20170183 DOI: 10.1021/jf9040657  0.435
2009 Hussack G, Luo Y, Veldhuis L, Hall JC, Tanha J, Mackenzie R. Multivalent anchoring and oriented display of single-domain antibodies on cellulose. Sensors (Basel, Switzerland). 9: 5351-67. PMID 22346702 DOI: 10.3390/S90705351  0.738
2009 Doyle PJ, Saeed H, Hermans A, Gleddie SC, Hussack G, Arbabi-Ghahroudi M, Seguin C, Savard ME, Mackenzie CR, Hall JC. Intracellular expression of a single domain antibody reduces cytotoxicity of 15-acetyldeoxynivalenol in yeast. The Journal of Biological Chemistry. 284: 35029-39. PMID 19783651 DOI: 10.1074/Jbc.M109.045047  0.429
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