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Kristen Pauken, Ph.D. - Publications

Affiliations: 
2013 Microbiology, Immunology and Cancer Biology University of Minnesota, Twin Cities, Minneapolis, MN 
Area:
Immunology
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41 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Keshari S, Shavkunov AS, Miao Q, Saha A, Williams CD, Highsmith AM, Pineda JE, Alspach E, Hu KH, Pauken KE, Chen K, Gubin MM. Overlapping and Distinct Mechanisms of Effective Neoantigen Cancer Vaccines and Immune Checkpoint Therapy. Biorxiv : the Preprint Server For Biology. PMID 38187708 DOI: 10.1101/2023.12.20.570816  0.312
2023 Rowe JH, Elia I, Shahid O, Gaudiano EF, Sifnugel NE, Johnson S, Reynolds AG, Fung ME, Joshi S, LaFleur MW, Park JS, Pauken KE, Rabinowitz JD, Freeman GJ, Haigis MC, et al. Formate supplementation enhances anti-tumor CD8+ T cell fitness and efficacy of PD-1 blockade. Cancer Discovery. PMID 37728660 DOI: 10.1158/2159-8290.CD-22-1301  0.517
2023 Collier JL, Pauken KE, Lee CAA, Patterson DG, Markson SC, Conway TS, Fung ME, France JA, Mucciarone KN, Lian CG, Murphy GF, Sharpe AH. Single-cell profiling reveals unique features of diabetogenic T cells in anti-PD-1-induced type 1 diabetes mice. The Journal of Experimental Medicine. 220. PMID 37432393 DOI: 10.1084/jem.20221920  0.727
2023 Schenkel JM, Pauken KE. Localization, tissue biology and T cell state - implications for cancer immunotherapy. Nature Reviews. Immunology. PMID 37253877 DOI: 10.1038/s41577-023-00884-8  0.369
2022 Alvarez-Breckenridge C, Markson SC, Stocking JH, Nayyar N, Lastrapes M, Strickland MR, Kim AE, de Sauvage M, Dahal A, Larson JM, Mora JL, Navia AW, Klein RH, Kuter BM, Gill CM, ... ... Pauken KE, et al. Microenvironmental landscape of human melanoma brain metastases in response to immune checkpoint inhibition. Cancer Immunology Research. PMID 35706413 DOI: 10.1158/2326-6066.CIR-21-0870  0.314
2022 Lagattuta KA, Kang JB, Nathan A, Pauken KE, Jonsson AH, Rao DA, Sharpe AH, Ishigaki K, Raychaudhuri S. Repertoire analyses reveal T cell antigen receptor sequence features that influence T cell fate. Nature Immunology. PMID 35177831 DOI: 10.1038/s41590-022-01129-x  0.354
2022 Pauken KE, Lagattuta KA, Lu BY, Lucca LE, Daud AI, Hafler DA, Kluger HM, Raychaudhuri S, Sharpe AH. TCR-sequencing in cancer and autoimmunity: barcodes and beyond. Trends in Immunology. PMID 35090787 DOI: 10.1016/j.it.2022.01.002  0.439
2021 Schenkel JM, Herbst RH, Canner D, Li A, Hillman M, Shanahan SL, Gibbons G, Smith OC, Kim JY, Westcott P, Hwang WL, Freed-Pastor WA, Eng G, Cuoco MS, Rogers P, ... ... Pauken KE, et al. Conventional type I dendric cells maintain a reservoir of proliferative tumor-antigen specific TCF-1 CD8 T cells in tumor-draining lymph nodes. Immunity. PMID 34534439 DOI: 10.1016/j.immuni.2021.08.026  0.391
2021 Collier JL, Weiss SA, Pauken KE, Sen DR, Sharpe AH. Not-so-opposite ends of the spectrum: CD8 T cell dysfunction across chronic infection, cancer and autoimmunity. Nature Immunology. PMID 34140679 DOI: 10.1038/s41590-021-00949-7  0.381
2021 Pauken KE, Torchia JA, Chaudhri A, Sharpe AH, Freeman GJ. Emerging concepts in PD-1 checkpoint biology. Seminars in Immunology. 101480. PMID 34006473 DOI: 10.1016/j.smim.2021.101480  0.63
2021 Pauken KE, Shahid O, Lagattuta KA, Mahuron KM, Luber JM, Lowe MM, Huang L, Delaney C, Long JM, Fung ME, Newcomer K, Tsai KK, Chow M, Guinn S, Kuchroo JR, et al. Single-cell analyses identify circulating anti-tumor CD8 T cells and markers for their enrichment. The Journal of Experimental Medicine. 218. PMID 33651880 DOI: 10.1084/jem.20200920  0.448
2021 Lo JA, Kawakubo M, Juneja VR, Su MY, Erlich TH, LaFleur MW, Kemeny LV, Rashid M, Malehmir M, Rabi SA, Raghavan R, Allouche J, Kasumova G, Frederick DT, Pauken KE, et al. Epitope spreading toward wild-type melanocyte-lineage antigens rescues suboptimal immune checkpoint blockade responses. Science Translational Medicine. 13. PMID 33597266 DOI: 10.1126/scitranslmed.abd8636  0.452
2021 Johnnidis JB, Muroyama Y, Ngiow SF, Chen Z, Manne S, Cai Z, Song S, Platt JM, Schenkel JM, Abdel-Hakeem M, Beltra JC, Greenplate AR, Ali MA, Nzingha K, Giles JR, ... ... Pauken KE, et al. Inhibitory signaling sustains a distinct early memory CD8 T cell precursor that is resistant to DNA damage. Science Immunology. 6. PMID 33452106 DOI: 10.1126/sciimmunol.abe3702  0.433
2020 Chen IX, Newcomer K, Pauken KE, Juneja VR, Naxerova K, Wu MW, Pinter M, Sen DR, Singer M, Sharpe AH, Jain RK. A bilateral tumor model identifies transcriptional programs associated with patient response to immune checkpoint blockade. Proceedings of the National Academy of Sciences of the United States of America. PMID 32907939 DOI: 10.1073/Pnas.2002806117  0.368
2020 Pauken KE, Godec J, Odorizzi PM, Brown KE, Yates KB, Ngiow SF, Burke KP, Maleri S, Grande SM, Francisco LM, Ali MA, Imam S, Freeman GJ, Haining WN, Wherry EJ, et al. The PD-1 Pathway Regulates Development and Function of Memory CD8 T Cells following Respiratory Viral Infection. Cell Reports. 31: 107827. PMID 32610128 DOI: 10.1016/J.Celrep.2020.107827  0.609
2019 Pauken KE, Dougan M, Rose NR, Lichtman AH, Sharpe AH. Adverse Events Following Cancer Immunotherapy: Obstacles and Opportunities. Trends in Immunology. PMID 31053497 DOI: 10.1016/J.It.2019.04.002  0.437
2018 Osum KC, Burrack AL, Martinov T, Sahli NL, Mitchell JS, Tucker CG, Pauken KE, Papas K, Appakalai B, Spanier JA, Fife BT. Interferon-gamma drives programmed death-ligand 1 expression on islet β cells to limit T cell function during autoimmune diabetes. Scientific Reports. 8: 8295. PMID 29844327 DOI: 10.1038/S41598-018-26471-9  0.631
2017 Sharpe AH, Pauken KE. The diverse functions of the PD1 inhibitory pathway. Nature Reviews. Immunology. PMID 28990585 DOI: 10.1038/Nri.2017.108  0.598
2017 Huang AC, Postow MA, Orlowski RJ, Mick R, Bengsch B, Manne S, Xu W, Harmon S, Giles JR, Wenz B, Adamow M, Kuk D, Panageas KS, Carrera C, Wong P, ... ... Pauken KE, et al. T-cell invigoration to tumour burden ratio associated with anti-PD-1 response. Nature. PMID 28397821 DOI: 10.1038/Nature22079  0.616
2016 Benci JL, Xu B, Qiu Y, Wu TJ, Dada H, Twyman-Saint Victor C, Cucolo L, Lee DS, Pauken KE, Huang AC, Gangadhar TC, Amaravadi RK, Schuchter LM, Feldman MD, Ishwaran H, et al. Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade. Cell. 167: 1540-1554.e12. PMID 27912061 DOI: 10.1016/J.Cell.2016.11.022  0.333
2016 Pauken KE, Sammons MA, Odorizzi PM, Manne S, Godec J, Khan O, Drake AM, Chen Z, Sen D, Kurachi M, Barnitz RA, Bartman C, Bengsch B, Huang AC, Schenkel JM, et al. Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade. Science (New York, N.Y.). PMID 27789795 DOI: 10.1126/Science.Aaf2807  0.688
2016 Martinov T, Spanier JA, Pauken KE, Fife BT. PD-1 pathway-mediated regulation of islet-specific CD4(+) T cell subsets in autoimmune diabetes. Immunoendocrinology (Houston, Tex.). 3. PMID 27656680 DOI: 10.14800/ie.1164  0.754
2016 Bengsch B, Johnson AL, Kurachi M, Odorizzi PM, Pauken KE, Attanasio J, Stelekati E, McLane LM, Paley MA, Delgoffe GM, Wherry EJ. Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8(+) T Cell Exhaustion. Immunity. PMID 27496729 DOI: 10.1016/J.Immuni.2016.07.008  0.527
2016 Kalekar LA, Schmiel SE, Nandiwada SL, Lam WY, Barsness LO, Zhang N, Stritesky GL, Malhotra D, Pauken KE, Linehan JL, O'Sullivan MG, Fife BT, Hogquist KA, Jenkins MK, Mueller DL. CD4(+) T cell anergy prevents autoimmunity and generates regulatory T cell precursors. Nature Immunology. PMID 26829766 DOI: 10.1038/Ni.3331  0.705
2016 Victor CT, Rech A, Maity A, Rengan R, Pauken K, Stelekati E, Benci J, Xu B, Dada H, Odorizzi P, Herati R, Mansfield K, Patsch D, Amaravadi R, Schuchter L, et al. Abstract A056: Mechanisms of tumor response and resistance to radiation and dual checkpoint blockade in mice and patients Cancer Immunology Research. 4. DOI: 10.1158/2326-6074.Cricimteatiaacr15-A056  0.698
2016 Huang A, Xu W, Harmon S, Quagliarello F, Herati R, Pauken K, Bengsch B, Schuchter L, Amaravadi R, McGettigan S, Gangadhar T, Wherry J. Abstract A036: Anti-PD1 therapy and CD8 T cell invigoration in metastatic melanoma Cancer Immunology Research. 4. DOI: 10.1158/2326-6074.Cricimteatiaacr15-A036  0.644
2016 Victor CT, Rech A, Benci J, Maity A, Rengan R, Pauken K, Stelekati E, Xu B, Dada H, Odorizzi P, Herati R, Amaravadi R, Schuchter L, Ishwaran H, Mick R, et al. Abstract PR05: Mechanisms of tumor response and resistance to radiation and dual checkpoint blockade in mice and patients Cancer Research. 76. DOI: 10.1158/1538-7445.Fbcr15-Pr05  0.67
2015 Pauken KE, Wherry EJ. SnapShot: T Cell Exhaustion. Cell. 163: 1038-1038.e1. PMID 26544946 DOI: 10.1016/J.Cell.2015.10.054  0.472
2015 Gupta PK, Godec J, Wolski D, Adland E, Yates K, Pauken KE, Cosgrove C, Ledderose C, Junger WG, Robson SC, Wherry EJ, Alter G, Goulder PJ, Klenerman P, Sharpe AH, et al. CD39 Expression Identifies Terminally Exhausted CD8+ T Cells. Plos Pathogens. 11: e1005177. PMID 26485519 DOI: 10.1371/Journal.Ppat.1005177  0.448
2015 Manlove LS, Berquam-Vrieze KE, Pauken KE, Williams RT, Jenkins MK, Farrar MA. Adaptive Immunity to Leukemia Is Inhibited by Cross-Reactive Induced Regulatory T Cells. Journal of Immunology (Baltimore, Md. : 1950). 195: 4028-37. PMID 26378075 DOI: 10.4049/Jimmunol.1501291  0.406
2015 Odorizzi PM, Pauken KE, Paley MA, Sharpe A, Wherry EJ. Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+ T cells. The Journal of Experimental Medicine. 212: 1125-37. PMID 26034050 DOI: 10.1084/Jem.20142237  0.679
2015 Pauken KE, Wherry EJ. Overcoming T cell exhaustion in infection and cancer. Trends in Immunology. 36: 265-76. PMID 25797516 DOI: 10.1016/J.It.2015.02.008  0.65
2015 Pauken KE, Nelson CE, Martinov T, Spanier JA, Heffernan JR, Sahli NL, Quarnstrom CF, Osum KC, Schenkel JM, Jenkins MK, Blazar BR, Vezys V, Fife BT. Cutting edge: identification of autoreactive CD4+ and CD8+ T cell subsets resistant to PD-1 pathway blockade. Journal of Immunology (Baltimore, Md. : 1950). 194: 3551-5. PMID 25769925 DOI: 10.4049/Jimmunol.1402262  0.752
2015 Twyman-Saint Victor C, Rech AJ, Maity A, Rengan R, Pauken KE, Stelekati E, Benci JL, Xu B, Dada H, Odorizzi PM, Herati RS, Mansfield KD, Patsch D, Amaravadi RK, Schuchter LM, et al. Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer. Nature. 520: 373-7. PMID 25754329 DOI: 10.1038/Nature14292  0.627
2014 Pauken KE, Wherry EJ. TIGIT and CD226: tipping the balance between costimulatory and coinhibitory molecules to augment the cancer immunotherapy toolkit. Cancer Cell. 26: 785-7. PMID 25490444 DOI: 10.1016/J.Ccell.2014.11.016  0.431
2014 Schenkel JM, Fraser KA, Beura LK, Pauken KE, Vezys V, Masopust D. T cell memory. Resident memory CD8 T cells trigger protective innate and adaptive immune responses. Science (New York, N.Y.). 346: 98-101. PMID 25170049 DOI: 10.1126/Science.1254536  0.371
2014 Schenkel JM, Fraser KA, Beura LK, Pauken KE, Vezys V, Masopust D. Resident memory CD8 t cells trigger protective innate and adaptive immune responses Science. 346: 98-101. DOI: 10.1126/science.l254536  0.326
2013 Pauken KE, Linehan JL, Spanier JA, Sahli NL, Kalekar LA, Binstadt BA, Moon JJ, Mueller DL, Jenkins MK, Fife BT. Cutting edge: type 1 diabetes occurs despite robust anergy among endogenous insulin-specific CD4 T cells in NOD mice. Journal of Immunology (Baltimore, Md. : 1950). 191: 4913-7. PMID 24123682 DOI: 10.4049/Jimmunol.1301927  0.771
2013 Pauken KE, Jenkins MK, Azuma M, Fife BT. PD-1, but not PD-L1, expressed by islet-reactive CD4+ T cells suppresses infiltration of the pancreas during type 1 diabetes. Diabetes. 62: 2859-69. PMID 23545706 DOI: 10.2337/Db12-1475  0.853
2011 Fife BT, Pauken KE. The role of the PD-1 pathway in autoimmunity and peripheral tolerance. Annals of the New York Academy of Sciences. 1217: 45-59. PMID 21276005 DOI: 10.1111/J.1749-6632.2010.05919.X  0.806
2009 Fife BT, Pauken KE, Eagar TN, Obu T, Wu J, Tang Q, Azuma M, Krummel MF, Bluestone JA. Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal. Nature Immunology. 10: 1185-92. PMID 19783989 DOI: 10.1038/Ni.1790  0.832
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