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Ian R. Wheeldon, Ph.D. - Publications

Affiliations: 
2009 Columbia University, New York, NY 
Area:
Chemical Engineering
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42 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Abdallah W, Hong X, Banta S, Wheeldon I. Microenvironmental effects can masquerade as substrate channelling in cascade biocatalysis. Current Opinion in Biotechnology. 73: 233-239. PMID 34521036 DOI: 10.1016/j.copbio.2021.08.014  0.596
2020 Lang X, Besada-Lombana PB, Li M, Da Silva NA, Wheeldon I. Developing a broad-range promoter set for metabolic engineering in the thermotolerant yeast . Metabolic Engineering Communications. 11: e00145. PMID 32995271 DOI: 10.1016/J.Mec.2020.E00145  0.362
2020 Whitehead TA, Banta S, Bentley WE, Betenbaugh MJ, Chan C, Clark DS, Hoesli CA, Jewett MC, Junker B, Koffas M, Kshirsagar R, Lewis A, Li CT, Maranas C, Terry Papoutsakis E, ... ... Wheeldon I, et al. The Importance and Future of Biochemical Engineering. Biotechnology and Bioengineering. PMID 32343367 DOI: 10.1002/Bit.27364  0.615
2020 Lang X, Hong X, Baker CA, Otto TC, Wheeldon I. Molecular Binding Scaffolds Increase Local Substrate Concentration Enhancing the Enzymatic Hydrolysis of VX Nerve Agent. Biotechnology and Bioengineering. PMID 32239488 DOI: 10.1002/Bit.27346  0.386
2020 Ramesh A, Ong T, Garcia JA, Adams J, Wheeldon I. Guide RNA engineering enables dual purpose CRISPR-Cpf1 for simultaneous gene editing and gene regulation in . Acs Synthetic Biology. PMID 32208677 DOI: 10.1021/Acssynbio.9B00498  0.4
2020 Thorwall S, Schwartz C, Chartron JW, Wheeldon I. Stress-tolerant non-conventional microbes enable next-generation chemical biosynthesis. Nature Chemical Biology. 16: 113-121. PMID 31974527 DOI: 10.1038/S41589-019-0452-X  0.322
2020 Banta S, Wheeldon I. Theory-Based Development of Performance Metrics for Comparing Multi-Reactant Enzymes Acs Catalysis. 10: 1123-1132. DOI: 10.1021/Acscatal.9B03491  0.606
2019 Schwartz C, Cheng JF, Evans R, Schwartz CA, Wagner JM, Anglin S, Beitz A, Pan W, Lonardi S, Blenner M, Alper HS, Yoshikuni Y, Wheeldon I. Validating genome-wide CRISPR-Cas9 function improves screening in the oleaginous yeast Yarrowia lipolytica. Metabolic Engineering. PMID 31216436 DOI: 10.1016/J.Ymben.2019.06.007  0.665
2019 Abdallah W, Chirino V, Wheeldon I, Banta SA. Engineering the Microenvironment of a Thermostable Alcohol Dehydrogenase via Fusion with Supercharged Proteins Improves Catalysis. Chembiochem : a European Journal of Chemical Biology. PMID 30859665 DOI: 10.1002/Cbic.201900066  0.61
2019 Lancaster L, Bulutoglu B, Banta S, Wheeldon I. Enzyme colocalization in protein-based hydrogels. Methods in Enzymology. 617: 265-285. PMID 30784405 DOI: 10.1016/Bs.Mie.2018.12.006  0.674
2019 Zhu J, Schwartz C, Wheeldon I. Controlled intracellular trafficking alleviates an expression bottleneck in ester biosynthesis. Metabolic Engineering Communications. 8: e00085. PMID 30622894 DOI: 10.1016/J.Mec.2018.E00085  0.429
2019 Wheeldon I, Ahari AF, Khademhosseini A. Microengineering hydrogels for stem cell bioengineering and tissue regeneration. Jala (Charlottesville, Va.). 15: 440-448. PMID 21344063 DOI: 10.1016/J.Jala.2010.05.003  0.314
2018 Löbs AK, Schwartz C, Thorwall S, Wheeldon I. Highly multiplexed CRISPRi repression of respiratory functions enhances mitochondrial localized ethyl acetate biosynthesis in Kluyveromyces marxianus. Acs Synthetic Biology. PMID 30354074 DOI: 10.1021/Acssynbio.8B00331  0.356
2018 Lancaster L, Abdallah W, Banta S, Wheeldon I. Engineering enzyme microenvironments for enhanced biocatalysis. Chemical Society Reviews. PMID 29796541 DOI: 10.1039/C8Cs00085A  0.673
2018 Schwartz C, Wheeldon I. CRISPR-Cas9-Mediated Genome Editing and Transcriptional Control in Yarrowia lipolytica. Methods in Molecular Biology (Clifton, N.J.). 1772: 327-345. PMID 29754237 DOI: 10.1007/978-1-4939-7795-6_18  0.361
2018 Schwartz C, Curtis N, Löbs AK, Wheeldon I. Multiplexed CRISPR activation of cryptic sugar metabolism enables Yarrowia lipolytica growth on cellobiose. Biotechnology Journal. e1700584. PMID 29729131 DOI: 10.1002/Biot.201700584  0.357
2017 Löbs AK, Schwartz C, Wheeldon I. Genome and metabolic engineering in non-conventional yeasts: Current advances and applications. Synthetic and Systems Biotechnology. 2: 198-207. PMID 29318200 DOI: 10.1016/J.Synbio.2017.08.002  0.413
2017 Schwartz C, Frogue K, Misa J, Wheeldon I. Host and Pathway Engineering for Enhanced Lycopene Biosynthesis in Yarrowia lipolytica. Frontiers in Microbiology. 8: 2233. PMID 29276501 DOI: 10.3389/Fmicb.2017.02233  0.377
2017 Schwartz C, Frogue K, Ramesh A, Misa J, Wheeldon I. CRISPRi repression of nonhomologous end-joining for enhanced genome engineering via homologous recombination in Yarrowia lipolytica. Biotechnology and Bioengineering. PMID 28832943 DOI: 10.1002/Bit.26404  0.369
2017 Lang X, Zhu L, Gao Y, Wheeldon I. Enhancing Enzyme Activity and Immobilization in Nanostructured Inorganic-Enzyme Complexes. Langmuir : the Acs Journal of Surfaces and Colloids. PMID 28813159 DOI: 10.1021/Acs.Langmuir.7B02004  0.364
2017 Shabbir-Hussain M, Wheeldon I, Blenner MA. A strong hybrid fatty acid inducible transcriptional sensor built from Yarrowia lipolytica upstream activating and regulatory sequences. Biotechnology Journal. PMID 28731568 DOI: 10.1002/Biot.201700248  0.664
2017 Lin JL, Zhu J, Wheeldon I. Synthetic Protein Scaffolds for Biosynthetic Pathway Co-Localization on Lipid Droplet Membranes. Acs Synthetic Biology. PMID 28497697 DOI: 10.1021/Acssynbio.7B00041  0.372
2017 Wheeldon I, Christopher P, Blanch H. Integration of heterogeneous and biochemical catalysis for production of fuels and chemicals from biomass. Current Opinion in Biotechnology. 45: 127-135. PMID 28365403 DOI: 10.1016/J.Copbio.2017.02.019  0.328
2016 Schwartz C, Shabbir-Hussain M, Frogue K, Blenner M, Wheeldon I. Standardized markerless gene integration for pathway engineering in Yarrowia lipolytica. Acs Synthetic Biology. PMID 27989123 DOI: 10.1021/Acssynbio.6B00285  0.672
2016 Löbs AK, Lin JL, Cook M, Wheeldon I. High throughput, colorimetric screening of microbial ester biosynthesis reveals high ethyl acetate production from Kluyveromyces marxianus on C5, C6, and C12 carbon sources. Biotechnology Journal. PMID 27528369 DOI: 10.1002/Biot.201600060  0.347
2016 Gao Y, Roberts C, Toop A, Chang CE, Wheeldon I. Mechanisms of enhanced catalysis in enzyme-DNA nanostructures revealed through molecular simulations and experimental analysis. Chembiochem : a European Journal of Chemical Biology. PMID 27173175 DOI: 10.1002/Cbic.201600224  0.353
2016 Wheeldon I, Minteer SD, Banta S, Barton SC, Atanassov P, Sigman M. Substrate channelling as an approach to cascade reactions. Nature Chemistry. 8: 299-309. PMID 27001725 DOI: 10.1038/Nchem.2459  0.584
2016 Lin JL, Zhu J, Wheeldon I. Rapid ester biosynthesis screening reveals a high activity alcohol-O-acyltransferase (AATase) from tomato fruit. Biotechnology Journal. PMID 26814045 DOI: 10.1002/Biot.201500406  0.357
2016 Schwartz CM, Hussain MS, Blenner M, Wheeldon I. Synthetic RNA Polymerase III Promoters Facilitate High-Efficiency CRISPR-Cas9-Mediated Genome Editing in Yarrowia lipolytica. Acs Synthetic Biology. 5: 356-9. PMID 26714206 DOI: 10.1021/Acssynbio.5B00162  0.668
2015 Zhu J, Lin JL, Palomec L, Wheeldon I. Microbial host selection affects intracellular localization and activity of alcohol-O-acetyltransferase. Microbial Cell Factories. 14: 35. PMID 25880435 DOI: 10.1186/S12934-015-0221-9  0.312
2015 Gao Y, Roberts CC, Zhu J, Lin JL, Chang CEA, Wheeldon I. Tuning Enzyme Kinetics through Designed Intermolecular Interactions Far from the Active Site Acs Catalysis. 5: 2149-2153. DOI: 10.1021/Acscatal.5B00130  0.384
2014 Lin J, Palomec L, Wheeldon I. Design and Analysis of Enhanced Catalysis in Scaffolded Multienzyme Cascade Reactions Acs Catalysis. 4: 505-511. DOI: 10.1021/Cs401009Z  0.41
2013 Lin J, Wheeldon I. Kinetic Enhancements in DNA–Enzyme Nanostructures Mimic the Sabatier Principle Acs Catalysis. 3: 560-564. DOI: 10.1021/Cs300766D  0.372
2011 Wheeldon I, Farhadi A, Bick AG, Jabbari E, Khademhosseini A. Nanoscale tissue engineering: spatial control over cell-materials interactions. Nanotechnology. 22: 212001. PMID 21451238 DOI: 10.1088/0957-4484/22/21/212001  0.339
2010 Campbell E, Wheeldon IR, Banta S. Broadening the cofactor specificity of a thermostable alcohol dehydrogenase using rational protein design introduces novel kinetic transient behavior. Biotechnology and Bioengineering. 107: 763-74. PMID 20632378 DOI: 10.1002/Bit.22869  0.723
2010 Lu HD, Wheeldon IR, Banta S. Catalytic biomaterials: engineering organophosphate hydrolase to form self-assembling enzymatic hydrogels. Protein Engineering, Design & Selection : Peds. 23: 559-66. PMID 20457694 DOI: 10.1093/Protein/Gzq026  0.664
2010 Banta S, Wheeldon IR, Blenner M. Protein engineering in the development of functional hydrogels. Annual Review of Biomedical Engineering. 12: 167-86. PMID 20420519 DOI: 10.1146/Annurev-Bioeng-070909-105334  0.736
2009 Wheeldon IR, Campbell E, Banta S. A chimeric fusion protein engineered with disparate functionalities-enzymatic activity and self-assembly. Journal of Molecular Biology. 392: 129-42. PMID 19577577 DOI: 10.1016/J.Jmb.2009.06.075  0.748
2008 Wheeldon IR, Gallaway JW, Barton SC, Banta S. Bioelectrocatalytic hydrogels from electron-conducting metallopolypeptides coassembled with bifunctional enzymatic building blocks. Proceedings of the National Academy of Sciences of the United States of America. 105: 15275-80. PMID 18824691 DOI: 10.1073/Pnas.0805249105  0.628
2008 Gallaway J, Wheeldon I, Rincon R, Atanassov P, Banta S, Barton SC. Oxygen-reducing enzyme cathodes produced from SLAC, a small laccase from Streptomyces coelicolor. Biosensors & Bioelectronics. 23: 1229-35. PMID 18096378 DOI: 10.1016/J.Bios.2007.11.004  0.598
2007 Wheeldon IR, Barton SC, Banta S. Bioactive proteinaceous hydrogels from designed bifunctional building blocks. Biomacromolecules. 8: 2990-4. PMID 17887795 DOI: 10.1021/Bm700858P  0.632
2005 Calvo EJ, Rothacher MS, Bonazzola C, Wheeldon IR, Salvarezza RC, Vela ME, Benitez G. Biomimetics with a self-assembled monolayer of catalytically active tethered isoalloxazine on Au. Langmuir : the Acs Journal of Surfaces and Colloids. 21: 7907-11. PMID 16089399 DOI: 10.1021/La050695N  0.313
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