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Matthew A. Hummel, Ph.D. - Publications

Affiliations: 
2004 University of Minnesota, Twin Cities, Minneapolis, MN 
Area:
Pharmacology, Pharmacy
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9 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2008 Mosher CM, Hummel MA, Tracy TS, Rettie AE. Functional analysis of phenylalanine residues in the active site of cytochrome P450 2C9. Biochemistry. 47: 11725-34. PMID 18922023 DOI: 10.1021/Bi801231M  0.598
2008 Hummel MA, Gannett PM, Aguilar J, Tracy TS. Substrate proton to heme distances in CYP2C9 allelic variants and alterations by the heterotropic activator, dapsone. Archives of Biochemistry and Biophysics. 475: 175-83. PMID 18485885 DOI: 10.1016/J.Abb.2008.04.034  0.653
2006 Hummel MA, Tracy TS, Hutzler JM, Wahlstrom JL, Zhou Y, Rock DA. Influence of fluorescent probe size and cytochrome b5 on drug-drug interactions in CYP2C9 Journal of Biomolecular Screening. 11: 303-309. PMID 16490777 DOI: 10.1177/1087057105285612  0.609
2005 Hummel MA, Locuson CW, Gannett PM, Rock DA, Mosher CM, Rettie AE, Tracy TS. CYP2C9 genotype-dependent effects on in vitro drug-drug interactions: switching of benzbromarone effect from inhibition to activation in the CYP2C9.3 variant. Molecular Pharmacology. 68: 644-51. PMID 15955872 DOI: 10.1124/Mol.105.013763  0.686
2004 Tracy TS, Hummel MA. Modeling kinetic data from in vitro drug metabolism enzyme experiments. Drug Metabolism Reviews. 36: 231-42. PMID 15237853 DOI: 10.1081/Dmr-120033999  0.625
2004 Hummel MA, Gannett PM, Aguilar JS, Tracy TS. Effector-mediated alteration of substrate orientation in cytochrome P450 2C9. Biochemistry. 43: 7207-14. PMID 15170358 DOI: 10.1021/Bi036158O  0.647
2004 Hummel MA, Dickmann LJ, Rettie AE, Haining RL, Tracy TS. Differential activation of CYP2C9 variants by dapsone. Biochemical Pharmacology. 67: 1831-41. PMID 15130760 DOI: 10.1016/J.Bcp.2004.01.017  0.667
2002 Hutzler JM, Kolwankar D, Hummel MA, Tracy TS. Activation of CYP2C9-mediated metabolism by a series of dapsone analogs: kinetics and structural requirements. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 30: 1194-200. PMID 12386124 DOI: 10.1124/Dmd.30.11.1194  0.657
2002 Tracy TS, Hutzler JM, Haining RL, Rettie AE, Hummel MA, Dickmann LJ. Polymorphic variants (CYP2C9*3 and CYP2C9*5) and the F114L active site mutation of CYP2C9: effect on atypical kinetic metabolism profiles. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 30: 385-90. PMID 11901091 DOI: 10.1124/Dmd.30.4.385  0.669
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