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Jonathan M. Backer - Publications

Affiliations: 
Yeshiva University, New York, NY, United States 
Area:
Cell Biology, Biochemistry
Website:
http://www.einstein.yu.edu/faculty/283/jonathan-backer/

140 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Salloum G, Bresnick AR, Backer JM. Macropinocytosis: mechanisms and regulation. The Biochemical Journal. 480: 335-362. PMID 36920093 DOI: 10.1042/BCJ20210584  0.308
2022 Jakubik CT, Weckerly CC, Hammond GRV, Bresnick AR, Backer JM. PIP abundance overcomes PI3K signaling selectivity in invadopodia. Febs Letters. PMID 34990021 DOI: 10.1002/1873-3468.14273  0.329
2019 Salloum G, Jakubik CT, Erami Z, Heitz SD, Bresnick AR, Backer JM. PI3Kβ is selectively required for growth factor-stimulated macropinocytosis. Journal of Cell Science. PMID 31409694 DOI: 10.1242/Jcs.231639  0.483
2019 Erami Z, Heitz S, Bresnick AR, Backer JM. PI3Kβ links integrin activation and PI(3,4)P production during invadopodial maturation. Molecular Biology of the Cell. mbcE19030182. PMID 31318314 DOI: 10.1091/Mbc.E19-03-0182  0.461
2019 Heitz SD, Hamelin DJ, Hoffmann RM, Greenberg N, Salloum G, Erami Z, Khalil BD, Shymanets A, Steidle EA, Gong GQ, Nürnberg B, Burke JE, Flanagan JU, Bresnick AR, Backer JM. A Single Discrete Rab5 Binding Site in PI3Kβ is Required for Tumor Cell Invasion. The Journal of Biological Chemistry. PMID 30659094 DOI: 10.1074/Jbc.Ra118.006032  0.442
2019 Bresnick AR, Backer JM. PI3Kβ - a versatile transducer for GPCR, RTK and small GTPase signaling. Endocrinology. PMID 30601996 DOI: 10.1210/En.2018-00843  0.45
2019 Salloum G, Jakubik C, Bresnick AR, Backer JM. Abstract 3431: PI3Kbeta regulates macropinocytosis in PTEN-null tumor cells Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-3431  0.329
2018 Norwood Toro LE, Wang Y, Condeelis JS, Jones JG, Backer J, Bresnick AR. Myosin-IIA Heavy Chain Phosphorylation on S1943 Regulates Tumor Metastasis. Experimental Cell Research. PMID 29953877 DOI: 10.1016/J.Yexcr.2018.06.028  0.39
2018 Erami Z, Bresnick AR, Backer JM. Abstract 3165: PI 3-kinase-beta regulates invadopodia maturation and beta-1 integrin signaling Cancer Research. 78: 3165-3165. DOI: 10.1158/1538-7445.Am2018-3165  0.325
2017 Dulyaninova NG, Ruiz PD, Gamble MJ, Backer JM, Bresnick AR. S100A4 Regulates Macrophage Invasion by Distinct Myosin-Dependent and Independent Mechanisms. Molecular Biology of the Cell. PMID 29282275 DOI: 10.1091/Mbc.E17-07-0460  0.333
2017 Bilanges B, Alliouachene S, Pearce W, Morelli D, Szabadkai G, Chung YL, Chicanne G, Valet C, Hill JM, Voshol PJ, Collinson L, Peddie C, Ali K, Ghazaly E, Rajeeve V, ... ... Backer JM, et al. Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism. Nature Communications. 8: 1804. PMID 29180704 DOI: 10.1038/S41467-017-01969-4  0.364
2017 Erami Z, Khalil BD, Salloum G, Yao Y, LoPiccolo J, Shymanets A, Nürnberg B, Bresnick AR, Backer JM. -----Rac1-Stimulated Macropinocytosis Enhances Gβϒ Activation of PI3Kβ. The Biochemical Journal. PMID 29046393 DOI: 10.1042/Bcj20170279  0.469
2016 Houslay DM, Anderson KE, Chessa T, Kulkarni S, Fritsch R, Downward J, Backer JM, Stephens LR, Hawkins PT. Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells. Science Signaling. 9: ra82. PMID 27531651 DOI: 10.1126/Scisignal.Aae0453  0.446
2016 Backer JM. The intricate regulation and complex functions of the Class III phosphoinositide 3-kinase Vps34. The Biochemical Journal. 473: 2251-71. PMID 27470591 DOI: 10.1042/Bcj20160170  0.412
2016 Khalil BD, Hsueh C, Cao Y, Abi Saab WF, Wang Y, Condeelis JS, Bresnick AR, Backer JM. GPCR signaling mediates tumor metastasis via PI3Kβ. Cancer Research. PMID 27013201 DOI: 10.1158/0008-5472.Can-15-1675  0.445
2016 Toro LEN, Backer JM, Bresnick AR. Abstract 5060: Myosin-IIA heavy chain phosphorylation on S1943 regulates tumor cell invasion Cancer Research. 76: 5060-5060. DOI: 10.1158/1538-7445.Am2016-5060  0.385
2016 Mandal PK, Yao Y, Bresnick AR, Backer JM, McMurray JS. Abstract 4838: Peptide prodrugs targeting the SH2 domains of p85 block PI3K signaling Cancer Research. 76: 4838-4838. DOI: 10.1158/1538-7445.Am2016-4838  0.514
2015 Alliouachene S, Bilanges B, Chicanne G, Anderson KE, Pearce W, Ali K, Valet C, Posor Y, Low PC, Chaussade C, Scudamore CL, Salamon RS, Backer JM, Stephens L, Hawkins PT, et al. Inactivation of the Class II PI3K-C2β Potentiates Insulin Signaling and Sensitivity. Cell Reports. 13: 1881-94. PMID 26655903 DOI: 10.1016/J.Celrep.2015.10.052  0.389
2015 LoPiccolo J, Kim SJ, Shi Y, Wu B, Wu H, Chait BT, Singer RH, Sali A, Brenowitz M, Bresnick AR, Backer JM. Assembly and Molecular Architecture of the Phosphoinositide 3-Kinase p85α Homodimer. The Journal of Biological Chemistry. PMID 26475863 DOI: 10.1074/Jbc.M115.689604  0.42
2015 Braccini L, Ciraolo E, Campa CC, Perino A, Longo DL, Tibolla G, Pregnolato M, Cao Y, Tassone B, Damilano F, Laffargue M, Calautti E, Falasca M, Norata GD, Backer JM, et al. PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling. Nature Communications. 6: 7400. PMID 26100075 DOI: 10.1038/Ncomms8400  0.408
2015 Jeschke A, Zehethofer N, Lindner B, Krupp J, Schwudke D, Haneburger I, Jovic M, Backer JM, Balla T, Hilbi H, Haas A. Phosphatidylinositol 4-phosphate and phosphatidylinositol 3-phosphate regulate phagolysosome biogenesis. Proceedings of the National Academy of Sciences of the United States of America. 112: 4636-41. PMID 25825728 DOI: 10.1073/Pnas.1423456112  0.413
2015 Salamon RS, Dbouk HA, Collado D, Lopiccolo J, Bresnick AR, Backer JM. Identification of the Rab5 binding site in p110β: assays for PI3Kβ binding to Rab5. Methods in Molecular Biology (Clifton, N.J.). 1298: 271-81. PMID 25800850 DOI: 10.1007/978-1-4939-2569-8_23  0.759
2014 Shemesh A, Wang Y, Yang Y, Yang GS, Johnson DE, Backer JM, Pessin JE, Zong H. Suppression of mTORC1 activation in acid-α-glucosidase-deficient cells and mice is ameliorated by leucine supplementation. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 307: R1251-9. PMID 25231351 DOI: 10.1152/Ajpregu.00212.2014  0.309
2014 Cao Y, Wang Y, Abi Saab WF, Yang F, Pessin JE, Backer JM. NRBF2 regulates macroautophagy as a component of Vps34 Complex I. The Biochemical Journal. 461: 315-22. PMID 24785657 DOI: 10.1042/Bj20140515  0.386
2013 Vadas O, Dbouk HA, Shymanets A, Perisic O, Burke JE, Abi Saab WF, Khalil BD, Harteneck C, Bresnick AR, Nürnberg B, Backer JM, Williams RL. Molecular determinants of PI3Kγ-mediated activation downstream of G-protein-coupled receptors (GPCRs). Proceedings of the National Academy of Sciences of the United States of America. 110: 18862-7. PMID 24190998 DOI: 10.1073/Pnas.1304801110  0.781
2013 Salamon RS, Backer JM. Phosphatidylinositol-3,4,5-trisphosphate: tool of choice for class I PI 3-kinases. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 35: 602-11. PMID 23765576 DOI: 10.1002/Bies.201200176  0.46
2013 Dbouk HA, Khalil BD, Wu H, Shymanets A, Nürnberg B, Backer JM. Characterization of a tumor-associated activating mutation of the p110β PI 3-kinase. Plos One. 8: e63833. PMID 23734178 DOI: 10.1371/Journal.Pone.0063833  0.784
2013 Dou Z, Pan JA, Dbouk HA, Ballou LM, DeLeon JL, Fan Y, Chen JS, Liang Z, Li G, Backer JM, Lin RZ, Zong WX. Class IA PI3K p110β subunit promotes autophagy through Rab5 small GTPase in response to growth factor limitation. Molecular Cell. 50: 29-42. PMID 23434372 DOI: 10.1016/J.Molcel.2013.01.022  0.764
2013 Dbouk HA, Backer JM. Novel approaches to inhibitor design for the p110β phosphoinositide 3-kinase. Trends in Pharmacological Sciences. 34: 149-53. PMID 23411347 DOI: 10.1016/J.Tips.2012.12.004  0.783
2013 Brower ET, Gabelli SB, Wang Q, Chaerkady R, Berndsen CE, Cole RN, Backer JM, Schäfer M, Sinz A, Kinzler KW, Vogelstein B, Amzel LM. Abstract 2225: The molecular architecture of p85α as determined by SAXS and chemical cross-linking. Cancer Research. 73: 2225-2225. DOI: 10.1158/1538-7445.Am2013-2225  0.424
2012 Dbouk HA, Vadas O, Williams RL, Backer JM. PI3Kβ downstream of GPCRs - crucial partners in oncogenesis. Oncotarget. 3: 1485-6. PMID 23328076 DOI: 10.18632/Oncotarget.787  0.807
2012 Dbouk HA, Vadas O, Shymanets A, Burke JE, Salamon RS, Khalil BD, Barrett MO, Waldo GL, Surve C, Hsueh C, Perisic O, Harteneck C, Shepherd PR, Harden TK, Smrcka AV, ... ... Backer JM, et al. G protein-coupled receptor-mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness. Science Signaling. 5: ra89. PMID 23211529 DOI: 10.1126/Scisignal.2003264  0.791
2012 Smirnova T, Zhou ZN, Flinn RJ, Wyckoff J, Boimel PJ, Pozzuto M, Coniglio SJ, Backer JM, Bresnick AR, Condeelis JS, Hynes NE, Segall JE. Phosphoinositide 3-kinase signaling is critical for ErbB3-driven breast cancer cell motility and metastasis. Oncogene. 31: 706-15. PMID 21725367 DOI: 10.1038/Onc.2011.275  0.82
2011 Cai X, Srivastava S, Sun Y, Li Z, Wu H, Zuvela-Jelaska L, Li J, Salamon RS, Backer JM, Skolnik EY. Tripartite motif containing protein 27 negatively regulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2β. Proceedings of the National Academy of Sciences of the United States of America. 108: 20072-7. PMID 22128329 DOI: 10.1073/Pnas.1111233109  0.335
2011 Yoon MS, Du G, Backer JM, Frohman MA, Chen J. Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway. The Journal of Cell Biology. 195: 435-47. PMID 22024166 DOI: 10.1083/Jcb.201107033  0.409
2010 Dbouk HA, Backer JM. A beta version of life: p110β takes center stage. Oncotarget. 1: 729-33. PMID 21321382 DOI: 10.18632/Oncotarget.207  0.76
2010 Bohdanowicz M, Cosío G, Backer JM, Grinstein S. Class I and class III phosphoinositide 3-kinases are required for actin polymerization that propels phagosomes. The Journal of Cell Biology. 191: 999-1012. PMID 21115805 DOI: 10.1083/Jcb.201004005  0.427
2010 Dbouk HA, Pang H, Fiser A, Backer JM. A biochemical mechanism for the oncogenic potential of the p110beta catalytic subunit of phosphoinositide 3-kinase. Proceedings of the National Academy of Sciences of the United States of America. 107: 19897-902. PMID 21030680 DOI: 10.1073/Pnas.1008739107  0.79
2010 Backer JM. The regulation of class IA PI 3-kinases by inter-subunit interactions. Current Topics in Microbiology and Immunology. 346: 87-114. PMID 20544340 DOI: 10.1007/82_2010_52  0.345
2010 Backer JM. New methods for capturing the mystery lipid, PtdIns5P. The Biochemical Journal. 428: e1-2. PMID 20504279 DOI: 10.1042/Bj20100688  0.435
2010 Flinn RJ, Backer JM. mTORC1 signals from late endosomes: taking a TOR of the endocytic system. Cell Cycle (Georgetown, Tex.). 9: 1869-70. PMID 20436274 DOI: 10.4161/Cc.9.10.11679  0.806
2010 Sen KI, Wu H, Backer JM, Gerfen GJ. The structure of p85ni in class IA phosphoinositide 3-kinase exhibits interdomain disorder. Biochemistry. 49: 2159-66. PMID 20131869 DOI: 10.1021/Bi902171D  0.398
2010 Flinn RJ, Yan Y, Goswami S, Parker PJ, Backer JM. The late endosome is essential for mTORC1 signaling. Molecular Biology of the Cell. 21: 833-41. PMID 20053679 DOI: 10.1091/Mbc.E09-09-0756  0.802
2010 Jaiswal BS, Janakiraman V, Chaudhuri S, Stern HM, Kljavin NM, Wang W, Kan Z, Bowman K, Wu J, Kaminker J, Yue P, Sauvage FJd, Backer J, Seshagiri S. Abstract 305: Frequent PIK3R1 somatic mutations promote oncogenic signaling Cancer Research. 70: 305-305. DOI: 10.1158/1538-7445.Am10-305  0.427
2009 Jaiswal BS, Janakiraman V, Kljavin NM, Chaudhuri S, Stern HM, Wang W, Kan Z, Dbouk HA, Peters BA, Waring P, Dela Vega T, Kenski DM, Bowman KK, Lorenzo M, Li H, ... ... Backer JM, et al. Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation. Cancer Cell. 16: 463-74. PMID 19962665 DOI: 10.1016/J.Ccr.2009.10.016  0.786
2009 Wu H, Shekar SC, Flinn RJ, El-Sibai M, Jaiswal BS, Sen KI, Janakiraman V, Seshagiri S, Gerfen GJ, Girvin ME, Backer JM. Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110alpha and are disrupted in oncogenic p85 mutants. Proceedings of the National Academy of Sciences of the United States of America. 106: 20258-63. PMID 19915146 DOI: 10.1073/Pnas.0902369106  0.78
2009 Pang H, Flinn R, Patsialou A, Wyckoff J, Roussos ET, Wu H, Pozzuto M, Goswami S, Condeelis JS, Bresnick AR, Segall JE, Backer JM. Differential enhancement of breast cancer cell motility and metastasis by helical and kinase domain mutations of class IA phosphoinositide 3-kinase. Cancer Research. 69: 8868-76. PMID 19903845 DOI: 10.1158/0008-5472.Can-09-1968  0.809
2009 Srivastava S, Di L, Zhdanova O, Li Z, Vardhana S, Wan Q, Yan Y, Varma R, Backer J, Wulff H, Dustin ML, Skolnik EY. The class II phosphatidylinositol 3 kinase C2beta is required for the activation of the K+ channel KCa3.1 and CD4 T-cells. Molecular Biology of the Cell. 20: 3783-91. PMID 19587117 DOI: 10.1091/Mbc.E09-05-0390  0.4
2009 Zhong Y, Wang QJ, Li X, Yan Y, Backer JM, Chait BT, Heintz N, Yue Z. Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex. Nature Cell Biology. 11: 468-76. PMID 19270693 DOI: 10.1038/Ncb1854  0.445
2009 Yan Y, Flinn RJ, Wu H, Schnur RS, Backer JM. hVps15, but not Ca2+/CaM, is required for the activity and regulation of hVps34 in mammalian cells. The Biochemical Journal. 417: 747-55. PMID 18957027 DOI: 10.1042/Bj20081865  0.796
2008 Ciraolo E, Iezzi M, Marone R, Marengo S, Curcio C, Costa C, Azzolino O, Gonella C, Rubinetto C, Wu H, Dastrù W, Martin EL, Silengo L, Altruda F, Turco E, ... ... Backer JM, et al. Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development. Science Signaling. 1: ra3. PMID 18780892 DOI: 10.1126/Scisignal.1161577  0.46
2008 Ono H, Pocai A, Wang Y, Sakoda H, Asano T, Backer JM, Schwartz GJ, Rossetti L. Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats. The Journal of Clinical Investigation. 118: 2959-68. PMID 18618016 DOI: 10.1172/Jci34277  0.327
2008 Cao C, Backer JM, Laporte J, Bedrick EJ, Wandinger-Ness A. Sequential actions of myotubularin lipid phosphatases regulate endosomal PI(3)P and growth factor receptor trafficking. Molecular Biology of the Cell. 19: 3334-46. PMID 18524850 DOI: 10.1091/Mbc.E08-04-0367  0.488
2008 Juhász G, Hill JH, Yan Y, Sass M, Baehrecke EH, Backer JM, Neufeld TP. The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila. The Journal of Cell Biology. 181: 655-66. PMID 18474623 DOI: 10.1083/Jcb.200712051  0.48
2008 Sarmiento C, Wang W, Dovas A, Yamaguchi H, Sidani M, El-Sibai M, Desmarais V, Holman HA, Kitchen S, Backer JM, Alberts A, Condeelis J. WASP family members and formin proteins coordinate regulation of cell protrusions in carcinoma cells. The Journal of Cell Biology. 180: 1245-60. PMID 18362183 DOI: 10.1083/Jcb.200708123  0.667
2008 Weinger JG, Gohari P, Yan Y, Backer JM, Varnum B, Shafit-Zagardo B. In brain, Axl recruits Grb2 and the p85 regulatory subunit of PI3 kinase; in vitro mutagenesis defines the requisite binding sites for downstream Akt activation. Journal of Neurochemistry. 106: 134-46. PMID 18346204 DOI: 10.1111/J.1471-4159.2008.05343.X  0.498
2008 El-Sibai M, Pertz O, Pang H, Yip SC, Lorenz M, Symons M, Condeelis JS, Hahn KM, Backer JM. RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells. Experimental Cell Research. 314: 1540-52. PMID 18316075 DOI: 10.1016/J.Yexcr.2008.01.016  0.693
2008 Backer JM. The regulation and function of Class III PI3Ks: novel roles for Vps34. The Biochemical Journal. 410: 1-17. PMID 18215151 DOI: 10.1042/Bj20071427  0.43
2008 Yip SC, Eddy RJ, Branch AM, Pang H, Wu H, Yan Y, Drees BE, Neilsen PO, Condeelis J, Backer JM. Quantification of PtdIns(3,4,5)P(3) dynamics in EGF-stimulated carcinoma cells: a comparison of PH-domain-mediated methods with immunological methods. The Biochemical Journal. 411: 441-8. PMID 18215145 DOI: 10.1042/Bj20071179  0.399
2007 van Rheenen J, Song X, van Roosmalen W, Cammer M, Chen X, Desmarais V, Yip SC, Backer JM, Eddy RJ, Condeelis JS. EGF-induced PIP2 hydrolysis releases and activates cofilin locally in carcinoma cells. The Journal of Cell Biology. 179: 1247-59. PMID 18086920 DOI: 10.1083/Jcb.200706206  0.386
2007 Sidani M, Wessels D, Mouneimne G, Ghosh M, Goswami S, Sarmiento C, Wang W, Kuhl S, El-Sibai M, Backer JM, Eddy R, Soll D, Condeelis J. Cofilin determines the migration behavior and turning frequency of metastatic cancer cells. The Journal of Cell Biology. 179: 777-91. PMID 18025308 DOI: 10.1083/Jcb.200707009  0.651
2007 El-Sibai M, Nalbant P, Pang H, Flinn RJ, Sarmiento C, Macaluso F, Cammer M, Condeelis JS, Hahn KM, Backer JM. Cdc42 is required for EGF-stimulated protrusion and motility in MTLn3 carcinoma cells. Journal of Cell Science. 120: 3465-74. PMID 17855387 DOI: 10.1242/Jcs.005942  0.786
2007 Yip SC, El-Sibai M, Coniglio SJ, Mouneimne G, Eddy RJ, Drees BE, Neilsen PO, Goswami S, Symons M, Condeelis JS, Backer JM. The distinct roles of Ras and Rac in PI 3-kinase-dependent protrusion during EGF-stimulated cell migration. Journal of Cell Science. 120: 3138-46. PMID 17698922 DOI: 10.1242/Jcs.005298  0.703
2007 Cao C, Laporte J, Backer JM, Wandinger-Ness A, Stein MP. Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomes. Traffic (Copenhagen, Denmark). 8: 1052-67. PMID 17651088 DOI: 10.1111/J.1600-0854.2007.00586.X  0.464
2007 Miled N, Yan Y, Hon WC, Perisic O, Zvelebil M, Inbar Y, Schneidman-Duhovny D, Wolfson HJ, Backer JM, Williams RL. Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit. Science (New York, N.Y.). 317: 239-42. PMID 17626883 DOI: 10.1126/Science.1135394  0.407
2007 Chuang YY, Valster A, Coniglio SJ, Backer JM, Symons M. The atypical Rho family GTPase Wrch-1 regulates focal adhesion formation and cell migration. Journal of Cell Science. 120: 1927-34. PMID 17504809 DOI: 10.1242/Jcs.03456  0.422
2007 Wu H, Yan Y, Backer JM. Regulation of class IA PI3Ks. Biochemical Society Transactions. 35: 242-4. PMID 17371249 DOI: 10.1042/Bst0350242  0.5
2007 Yan Y, Backer JM. Regulation of class III (Vps34) PI3Ks. Biochemical Society Transactions. 35: 239-41. PMID 17371248 DOI: 10.1042/Bst0350239  0.458
2007 El-Sibai M, Backer JM. Phospholipase C gamma negatively regulates Rac/Cdc42 activation in antigen-stimulated mast cells. European Journal of Immunology. 37: 261-70. PMID 17163445 DOI: 10.1002/Eji.200635875  0.697
2006 Srivastava S, Li Z, Ko K, Choudhury P, Albaqumi M, Johnson AK, Yan Y, Backer JM, Unutmaz D, Coetzee WA, Skolnik EY. Histidine phosphorylation of the potassium channel KCa3.1 by nucleoside diphosphate kinase B is required for activation of KCa3.1 and CD4 T cells. Molecular Cell. 24: 665-75. PMID 17157250 DOI: 10.1016/J.Molcel.2006.11.012  0.373
2005 Murray JT, Backer JM. Analysis of hVps34/hVps15 interactions with Rab5 in Vivo and in Vitro Methods in Enzymology. 403: 789-799. PMID 16473639 DOI: 10.1016/S0076-6879(05)03068-5  0.441
2005 Nobukuni T, Joaquin M, Roccio M, Dann SG, Kim SY, Gulati P, Byfield MP, Backer JM, Natt F, Bos JL, Zwartkruis FJ, Thomas G. Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. Proceedings of the National Academy of Sciences of the United States of America. 102: 14238-43. PMID 16176982 DOI: 10.1073/Pnas.0506925102  0.72
2005 Backer JM. Substrate specificity: PI(3)Kgamma has it both ways. Nature Cell Biology. 7: 773-4. PMID 16056269 DOI: 10.1038/Ncb0805-773  0.434
2005 Byfield MP, Murray JT, Backer JM. hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase Journal of Biological Chemistry. 280: 33076-33082. PMID 16049009 DOI: 10.1074/Jbc.M507201200  0.764
2005 Shekar SC, Wu H, Fu Z, Yip SC, Nagajyothi, Cahill SM, Girvin ME, Backer JM. Mechanism of constitutive phosphoinositide 3-kinase activation by oncogenic mutants of the p85 regulatory subunit. The Journal of Biological Chemistry. 280: 27850-5. PMID 15932879 DOI: 10.1074/Jbc.M506005200  0.422
2005 Zamora-Leon SP, Bresnick A, Backer JM, Shafit-Zagardo B. Fyn phosphorylates human MAP-2c on tyrosine 67. The Journal of Biological Chemistry. 280: 1962-70. PMID 15536091 DOI: 10.1074/Jbc.M411380200  0.368
2004 Fu Z, Aronoff-Spencer E, Wu H, Gerfen GJ, Backer JM. The iSH2 domain of PI 3-kinase is a rigid tether for p110 and not a conformational switch. Archives of Biochemistry and Biophysics. 432: 244-51. PMID 15542063 DOI: 10.1016/J.Abb.2004.09.032  0.391
2004 Yip SC, El-Sibai M, Hill KM, Wu H, Fu Z, Condeelis JS, Backer JM. Over-expression of the p110beta but not p110alpha isoform of PI 3-kinase inhibits motility in breast cancer cells. Cell Motility and the Cytoskeleton. 59: 180-8. PMID 15468162 DOI: 10.1002/Cm.20032  0.746
2004 Mouneimne G, Soon L, DesMarais V, Sidani M, Song X, Yip SC, Ghosh M, Eddy R, Backer JM, Condeelis J. Phospholipase C and cofilin are required for carcinoma cell directionality in response to EGF stimulation. The Journal of Cell Biology. 166: 697-708. PMID 15337778 DOI: 10.1083/Jcb.200405156  0.418
2003 Kempiak SJ, Yip SC, Backer JM, Segall JE. Local signaling by the EGF receptor. The Journal of Cell Biology. 162: 781-7. PMID 12952932 DOI: 10.1083/Jcb.200303144  0.409
2003 Wu H, Windmiller DA, Wang L, Backer JM. YXXM motifs in the PDGF-beta receptor serve dual roles as phosphoinositide 3-kinase binding motifs and tyrosine-based endocytic sorting signals. The Journal of Biological Chemistry. 278: 40425-8. PMID 12941951 DOI: 10.1074/Jbc.C300225200  0.435
2003 Fu Z, Aronoff-Spencer E, Backer JM, Gerfen GJ. The structure of the inter-SH2 domain of class IA phosphoinositide 3-kinase determined by site-directed spin labeling EPR and homology modeling. Proceedings of the National Academy of Sciences of the United States of America. 100: 3275-80. PMID 12629217 DOI: 10.1073/Pnas.0535975100  0.438
2003 Windmiller DA, Backer JM. Distinct phosphoinositide 3-kinases mediate mast cell degranulation in response to G-protein-coupled versus FcepsilonRI receptors. The Journal of Biological Chemistry. 278: 11874-8. PMID 12529321 DOI: 10.1074/Jbc.M211787200  0.438
2002 Eskelinen EL, Prescott AR, Cooper J, Brachmann SM, Wang L, Tang X, Backer JM, Lucocq JM. Inhibition of autophagy in mitotic animal cells. Traffic (Copenhagen, Denmark). 3: 878-93. PMID 12453151 DOI: 10.1034/J.1600-0854.2002.31204.X  0.452
2002 Lu Z, Murray JT, Luo W, Li H, Wu X, Xu H, Backer JM, Chen YG. Transforming growth factor β activates Smad2 in the absence of receptor endocytosis Journal of Biological Chemistry. 277: 29363-29368. PMID 12034739 DOI: 10.1074/Jbc.M203495200  0.331
2002 Murray JT, Panaretou C, Stenmark H, Miaczynska M, Backer JM. Role of Rab5 in the recruitment of hVps34/p150 to the early endosome Traffic. 3: 416-427. PMID 12010460 DOI: 10.1034/J.1600-0854.2002.30605.X  0.439
2001 Futter CE, Collinson LM, Backer JM, Hopkins CR. Human VPS34 is required for internal vesicle formation within multivesicular endosomes. The Journal of Cell Biology. 155: 1251-64. PMID 11756475 DOI: 10.1083/Jcb.200108152  0.432
2001 Vieira OV, Botelho RJ, Rameh L, Brachmann SM, Matsuo T, Davidson HW, Schreiber A, Backer JM, Cantley LC, Grinstein S. Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation. The Journal of Cell Biology. 155: 19-25. PMID 11581283 DOI: 10.1083/Jcb.200107069  0.453
2001 Tuma PL, Nyasae LK, Backer JM, Hubbard AL. Vps34p differentially regulates endocytosis from the apical and basolateral domains in polarized hepatic cells. The Journal of Cell Biology. 154: 1197-208. PMID 11564757 DOI: 10.1083/Jcb.200105138  0.443
2001 Fratti RA, Backer JM, Gruenberg J, Corvera S, Deretic V. Role of phosphatidylinositol 3-kinase and Rab5 effectors in phagosomal biogenesis and mycobacterial phagosome maturation arrest. The Journal of Cell Biology. 154: 631-44. PMID 11489920 DOI: 10.1083/Jcb.200106049  0.421
2001 Condeelis JS, Wyckoff JB, Bailly M, Pestell R, Lawrence D, Backer J, Segall JE. Lamellipodia in invasion Seminars in Cancer Biology. 11: 119-128. PMID 11322831 DOI: 10.1006/Scbi.2000.0363  0.398
2001 Smith AJ, Surviladze Z, Gaudet EA, Backer JM, Mitchell CA, Wilson BS. p110beta and p110delta phosphatidylinositol 3-kinases up-regulate Fc(epsilon)RI-activated Ca2+ influx by enhancing inositol 1,4,5-trisphosphate production. The Journal of Biological Chemistry. 276: 17213-20. PMID 11279065 DOI: 10.1074/jbc.M100417200  0.306
2001 Hill KM, Huang Y, Yip SC, Yu J, Segall JE, Backer JM. N-terminal domains of the class ia phosphoinositide 3-kinase regulatory subunit play a role in cytoskeletal but not mitogenic signaling. The Journal of Biological Chemistry. 276: 16374-8. PMID 11278326 DOI: 10.1074/Jbc.M006985200  0.505
2000 Backer JM. Phosphoinositide 3-kinases and the regulation of vesicular trafficking Molecular Cell Biology Research Communications. 3: 193-204. PMID 10891392 DOI: 10.1006/Mcbr.2000.0202  0.413
2000 Siddhanta A, Backer JM, Shields D. Inhibition of phosphatidic acid synthesis alters the structure of the Golgi apparatus and inhibits secretion in endocrine cells Journal of Biological Chemistry. 275: 12023-12031. PMID 10766834 DOI: 10.1074/Jbc.275.16.12023  0.371
2000 Hill K, Welti S, Yu J, Murray JT, Yip SC, Condeelis JS, Segall JE, Backer JM. Specific requirement for the p85-p110alpha phosphatidylinositol 3-kinase during epidermal growth factor-stimulated actin nucleation in breast cancer cells. The Journal of Biological Chemistry. 275: 3741-4. PMID 10660520 DOI: 10.1074/Jbc.275.6.3741  0.428
2000 Backer JM. Erratum: Phosphoinositide 3-kinases and the regulation of vesicular trafficking (Molecular cell biology research communication (2000) 3:4 (193-204)) Molecular Cell Biology Research Communications. 3. DOI: 10.1006/Mcbr.2000.0233  0.354
1999 Nielsen E, Severin F, Backer JM, Hyman AA, Zerial M. Rab5 regulates motility of early endosomes on microtubules Nature Cell Biology. 1: 376-382. PMID 10559966 DOI: 10.1038/14075  0.383
1999 Christoforidis S, Miaczynska M, Ashman K, Wilm M, Zhao L, Yip SC, Waterfield MD, Backer JM, Zerial M. Phosphatidylinositol-3-OH kinases are Rab5 effectors. Nature Cell Biology. 1: 249-52. PMID 10559924 DOI: 10.1038/12075  0.385
1999 Hawkins M, Hu M, Yu J, Eder H, Vuguin P, She L, Barzilai N, Leiser M, Backer JM, Rossetti L. Discordant effects of glucosamine on insulin-stimulated glucose metabolism and phosphatidylinositol 3-kinase activity Journal of Biological Chemistry. 274: 31312-31319. PMID 10531330 DOI: 10.1074/Jbc.274.44.31312  0.339
1999 Cass LA, Summers SA, Prendergast GV, Backer JM, Birnbaum MJ, Meinkoth JL. Protein kinase A-dependent and -independent signaling pathways contribute to cyclic AMP-stimulated proliferation Molecular and Cellular Biology. 19: 5882-5891. PMID 10454535 DOI: 10.1128/Mcb.19.9.5882  0.486
1998 Siddhanta U, McIlroy J, Shah A, Zhang Y, Backer JM. Distinct roles for the p110α and hVPS34 phosphatidylinositol 3'- kinases in vesicular trafficking, regulation of the actin cytoskeleton, and mitogenesis Journal of Cell Biology. 143: 1647-1659. PMID 9852157 DOI: 10.1083/Jcb.143.6.1647  0.327
1998 Yu J, Wjasow C, Backer JM. Regulation of the p85/p110α phosphatidylinositol 3'-kinase: Distinct roles for the n-terminal and c-terminal sh2 domains Journal of Biological Chemistry. 273: 30199-30203. PMID 9804776 DOI: 10.1074/Jbc.273.46.30199  0.422
1998 Yu J, Zhang Y, McIlroy J, Rordorf-Nikolic T, Orr GA, Backer JM. Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit. Molecular and Cellular Biology. 18: 1379-87. PMID 9488453 DOI: 10.1128/Mcb.18.3.1379  0.433
1997 Backer JM, Wjasow C, Zhang Y. La vitro binding and phosphorylation of insulin receptor substrate 1 by the insulin receptor. Role of interactions mediated by the phosphotyrosine-binding domain and the pleckstrin-homology domain European Journal of Biochemistry. 245: 91-96. PMID 9128728 DOI: 10.1111/J.1432-1033.1997.T01-1-00091.X  0.383
1997 McIlroy J, Chen D, Wjasow C, Michaeli T, Backer JM. Specific activation of p85-p110 phosphatidylinositol 3'-kinase stimulates DNA synthesis by ras- and p70 S6 kinase-dependent pathways Molecular and Cellular Biology. 17: 248-255. PMID 8972205 DOI: 10.1128/Mcb.17.1.248  0.424
1996 Martys JL, Wjasow C, Gangi DM, Kielian MC, McGraw TE, Backer JM. Wortmannin-sensitive trafficking pathways in Chinese hamster ovary cells: Differential effects on endocytosis and lysosomal sorting Journal of Biological Chemistry. 271: 10953-10962. PMID 8631914 DOI: 10.1074/Jbc.271.18.10953  0.493
1995 Rordorf-Nikolic T, Van Horn DJ, Chen D, White MF, Backer JM. Regulation of phosphatidylinositol 3′-kinase by tyrosyl phosphoproteins: Full activation requires occupancy of both SH2 domains in the 85-kDa regulatory subunit Journal of Biological Chemistry. 270: 3662-3666. PMID 7876105 DOI: 10.1074/Jbc.270.8.3662  0.491
1995 Chen D, Van Horn DJ, White MF, Backer JM. Insulin receptor substrate 1 rescues insulin action in CHO cells expressing mutant insulin receptors that lack a juxtamembrane NPXY motif Molecular and Cellular Biology. 15: 4711-4717. PMID 7651388 DOI: 10.1128/Mcb.15.9.4711  0.388
1995 Myers MG, Cheatham B, Fisher TL, Jachna BR, Kahn CR, Backer JM, White MF. Common and distinct elements in insulin and PDGF signaling. Annals of the New York Academy of Sciences. 766: 369-87. PMID 7486683 DOI: 10.1111/J.1749-6632.1995.Tb26687.X  0.448
1994 Van Horn DJ, Myers MG, Backer JM. Direct activation of the phosphatidylinositol 3′-kinase by the insulin receptor Journal of Biological Chemistry. 269: 29-32. PMID 8276809  0.357
1993 Chuang LM, Myers MG, Backer JM, Shoelson SE, White MF, Birnbaum MJ, Kahn CR. Insulin-stimulated oocyte maturation requires insulin receptor substrate 1 and interaction with the SH2 domains of phosphatidylinositol 3-kinase. Molecular and Cellular Biology. 13: 6653-60. PMID 8413261 DOI: 10.1128/Mcb.13.11.6653  0.473
1993 Goncalves E, Yamada K, Thatte HS, Backer JM, Golan DE, Kahn CR, Shoelson SE. Optimizing transmembrane domain helicity accelerates insulin receptor internalization and lateral mobility. Proceedings of the National Academy of Sciences of the United States of America. 90: 5762-6. PMID 8390680 DOI: 10.1073/Pnas.90.12.5762  0.376
1993 Backer JM, Myers MG, Sun XJ, Chin DJ, Shoelson SE, Miralpeix M, White MF. Association of IRS-1 with the insulin receptor and the phosphatidylinositol 3'-kinase. Formation of binary and ternary signaling complexes in intact cells. The Journal of Biological Chemistry. 268: 8204-12. PMID 8385139  0.301
1993 Myers MG, Sun XJ, Cheatham B, Jachna BR, Glasheen EM, Backer JM, White MF. IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol 3′-kinase Endocrinology. 132: 1421-1430. PMID 8384986 DOI: 10.1210/Endo.132.4.8384986  0.428
1993 Piccione E, Case RD, Domchek SM, Hu P, Chaudhuri M, Backer JM, Schlessinger J, Shoelson SE. Phosphatidylinositol 3-kinase p85 SH2 domain specificity defined by direct phosphopeptide/SH2 domain binding. Biochemistry. 32: 3197-202. PMID 8384875 DOI: 10.1021/Bi00064A001  0.375
1993 Folli F, Saad MJA, Backer JM, Ronald Kahn C. Regulation of Phosphatidylinositol 3-kinase activity in liver and muscle of animal models of insulin-resistant and insulin-deficient diabetes mellitus Journal of Clinical Investigation. 92: 1787-1794. PMID 7691886 DOI: 10.1172/Jci116768  0.381
1993 Kahn CR, White MF, Shoelson SE, Backer JM, Araki E, Cheatham B, Csermely P, Folli F, Goldstein BJ, Huertas P. The insulin receptor and its substrate: molecular determinants of early events in insulin action. Recent Progress in Hormone Research. 48: 291-339. PMID 7680139 DOI: 10.1016/B978-0-12-571148-7.50015-4  0.328
1992 Backer JM, Shoelson SE, Weiss MA, Hua QX, Cheatham RB, Haring E, Cahill DC, White MF. The insulin receptor juxtamembrane region contains two independent tyrosine/beta-turn internalization signals. The Journal of Cell Biology. 118: 831-9. PMID 1500426 DOI: 10.1083/Jcb.118.4.831  0.346
1992 Meyerovitch J, Backer JM, Csermely P, Shoelson SE, Kahn CR. Insulin differentially regulates protein phosphotyrosine phosphatase activity in rat hepatoma cells. Biochemistry. 31: 10338-44. PMID 1420153 DOI: 10.1021/Bi00157A023  0.386
1992 Miralpeix M, Sun XJ, Backer JM, Myers MG, Araki E, White MF. Insulin stimulates tyrosine phosphorylation of multiple high molecular weight substrates in Fao hepatoma cells Biochemistry. 31: 9031-9039. PMID 1382584 DOI: 10.1021/Bi00152A046  0.366
1992 Backer JM, Myers MG, Shoelson SE, Chin DJ, Sun XJ, Miralpeix M, Hu P, Margolis B, Skolnik EY, Schlessinger J. Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation. The Embo Journal. 11: 3469-79. PMID 1380456 DOI: 10.1002/J.1460-2075.1992.Tb05426.X  0.452
1992 Myers MG, Backer JM, Sun XJ, Shoelson S, Hu P, Schlessinger J, Yoakim M, Schaffhausen B, White MF. IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85. Proceedings of the National Academy of Sciences of the United States of America. 89: 10350-4. PMID 1332046 DOI: 10.1073/Pnas.89.21.10350  0.467
1992 Backer JM, Schroeder GG, Kahn CR, Myers MG, Wilden PA, Cahill DA, White MF. Insulin stimulation of phosphatidylinositol 3-kinase activity maps to insulin receptor regions required for endogenous substrate phosphorylation Journal of Biological Chemistry. 267: 1367-1374. PMID 1309768  0.323
1991 Backer JM, King GL. Regulation of receptor-mediated endocytosis by phorbol esters Biochemical Pharmacology. 41: 1267-1277. PMID 1850281 DOI: 10.1016/0006-2952(91)90097-O  0.33
1991 Backer JM, Shoelson SE, Haring E, White MF. Insulin receptors internalize by a rapid, saturable pathway requiring receptor autophosphorylation and an intact juxtamembrane region. The Journal of Cell Biology. 115: 1535-45. PMID 1757462 DOI: 10.1083/Jcb.115.6.1535  0.328
1991 White MF, Backer JM. Preparation and use of anti-phosphotyrosine antibodies to study structure and function of insulin receptor Methods in Enzymology. 201: 65-79. PMID 1719349 DOI: 10.1016/0076-6879(91)01009-Q  0.343
1991 Kapeller R, Chen KS, Yoakim M, Schaffhausen BS, Backer J, White MF, Cantley LC, Ruderman NB. Mutations in the juxtamembrane region of the insulin receptor impair activation of phosphatidylinositol 3-kinase by insulin. Molecular Endocrinology (Baltimore, Md.). 5: 769-77. PMID 1656240 DOI: 10.1210/Mend-5-6-769  0.434
1991 Yamaguchi Y, Flier JS, Yokota A, Benecke H, Backer JM, Moller DE. Functional properties of two naturally occurring isoforms of the human insulin receptor in chinese hamster ovary cells Endocrinology. 129: 2058-2066. PMID 1655392 DOI: 10.1210/Endo-129-4-2058  0.328
1991 Sun XJ, Rothenberg P, Kahn CR, Backer JM, Araki E, Wilden PA, Cahill DA, Goldstein BJ, White MF. Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein Nature. 352: 73-76. PMID 1648180 DOI: 10.1038/352073A0  0.411
1991 Backer JM. Cytoplasmic juxtamembrane region of the insulin receptor: A critical role in ATP binding, endogenous substrate phosphorylation, and insulin-stimulated bioeffects in CHO cells Biochemistry. 30: 6366-6372. PMID 1647198 DOI: 10.1021/Bi00240A003  0.387
1990 Hu KQ, Backer JM, Sahagian G, Feener EP, King GL. Modulation of the insulin growth factor II/mannose 6-phosphate receptor of microvascular endothelial cells by phorbol ester via protein kinase C Journal of Biological Chemistry. 265: 13864-13870. PMID 2166043  0.303
1990 Wilden PA, Backer JM, Kahn CR, Cahill DA, Schroeder GJ, White MF. The insulin receptor with phenylalanine replacing tyrosine-1146 provides evidence for separate signals regulating cellular metabolism and growth Proceedings of the National Academy of Sciences of the United States of America. 87: 3358-3362. PMID 2159147 DOI: 10.1073/Pnas.87.9.3358  0.373
1989 Backer JM, Kahn CR, White MF. Tyrosine phosphorylation of the insulin receptor is not required for receptor internalization: Studies in 2,4-dinitrophenol-treated cells Proceedings of the National Academy of Sciences of the United States of America. 86: 3209-3213. PMID 2470095 DOI: 10.1073/Pnas.86.9.3209  0.329
1988 White MF, Livingston JN, Backer JM, Lauris V, Dull TJ, Ullrich A, Kahn CR. Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity Cell. 54: 641-649. PMID 2842060 DOI: 10.1016/S0092-8674(88)80008-4  0.405
1987 Backer JM, Dawidowicz EA. Reconstitution of a phospholipid flippase from rat liver microsomes Nature. 327: 341-343. PMID 3587349 DOI: 10.1038/327341A0  0.713
1981 Backer JM, Dawidowicz EA. Mechanism of cholesterol exchange between phospholipid vesicles Biochemistry. 20: 3805-3810. PMID 7272277 DOI: 10.1021/Bi00516A021  0.704
1981 Dawidowicz EA, Backer JM. The rapid transbilayer movement of thiocholesterol in small unilamellar phospholipid vesicles Bba - Biomembranes. 644: 373-375. PMID 7260079 DOI: 10.1016/0005-2736(81)90396-5  0.707
1981 Backer JM, Dawidowicz EA. Transmembrane movement of cholesterol in small unilamellar vesicles detected by cholesterol oxidase Journal of Biological Chemistry. 256: 586-588. PMID 6935193  0.69
1979 Backer JM, Dawidowicz EA. The rapid transmembrane movement of cholesterol in small unilamellar vesicles Biochimica Et Biophysica Acta. 551: 260-270. PMID 420833 DOI: 10.1016/0005-2736(89)90004-7  0.707
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