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Jeffery L. Brodsky - Publications

Affiliations: 
University of Pittsburgh, Pittsburgh, PA, United States 
Area:
Virology Biology, Molecular Biology, Biochemistry
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31 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Chung WJ, Goeckeler-Fried JL, Havasi V, Chiang A, Rowe SM, Plyler ZE, Hong JS, Mazur M, Piazza GA, Keeton AB, White EL, Rasmussen L, Weissman AM, Denny RA, Brodsky JL, et al. Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. Plos One. 11: e0163615. PMID 27732613 DOI: 10.1371/Journal.Pone.0163615  0.323
2016 Manos-Turvey A, Al-Ashtal HA, Needham PG, Hartline CB, Prichard MN, Wipf P, Brodsky JL. Dihydropyrimidinones and -thiones with improved activity against human polyomavirus family members. Bioorganic & Medicinal Chemistry Letters. PMID 27624078 DOI: 10.1016/J.Bmcl.2016.08.080  0.378
2016 Manos-Turvey A, Brodsky JL, Wipf P. The effect of structure and mechanism of the Hsp70 chaperone on the ability to identify chemical modulators and therapeutics Topics in Medicinal Chemistry. 19: 81-129. DOI: 10.1007/7355_2015_90  0.323
2015 An P, Brodsky JL, Pipas JM. The conserved core enzymatic activities and the distinct dynamics of polyomavirus large T antigens. Archives of Biochemistry and Biophysics. 573: 23-31. PMID 25752954 DOI: 10.1016/J.Abb.2015.02.033  0.332
2015 Sabnis AJ, Guerriero CJ, Brodsky JL, Bivona T. Abstract 481: Rationale for targeting the protein chaperone network in rhabdomyosarcoma Cancer Research. 75: 481-481. DOI: 10.1158/1538-7445.Am2015-481  0.34
2014 Howe MK, Bodoor K, Carlson DA, Hughes PF, Alwarawrah Y, Loiselle DR, Jaeger AM, Darr DB, Jordan JL, Hunter LM, Molzberger ET, Gobillot TA, Thiele DJ, Brodsky JL, Spector NL, et al. Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70. Chemistry & Biology. 21: 1648-59. PMID 25500222 DOI: 10.1016/J.Chembiol.2014.10.016  0.364
2014 Ireland AW, Gobillot TA, Gupta T, Seguin SP, Liang M, Resnick L, Goldberg MT, Manos-Turvey A, Pipas JM, Wipf P, Brodsky JL. Synthesis and structure–activity relationships of small molecule inhibitors of the simian virus 40 T antigen oncoprotein, an anti-polyomaviral target. Bioorganic & Medicinal Chemistry. 22: 6490-502. PMID 25440730 DOI: 10.1016/J.Bmc.2014.09.019  0.747
2014 Adam C, Baeurle A, Brodsky JL, Wipf P, Schrama D, Becker JC, Houben R. The HSP70 modulator MAL3-101 inhibits Merkel cell carcinoma. Plos One. 9: e92041. PMID 24694787 DOI: 10.1371/Journal.Pone.0092041  0.325
2014 Kang Y, Taldone T, Patel HJ, Patel PD, Rodina A, Gozman A, Maharaj R, Clement CC, Patel MR, Brodsky JL, Young JC, Chiosis G. Heat shock protein 70 inhibitors. 1. 2,5'-thiodipyrimidine and 5-(phenylthio)pyrimidine acrylamides as irreversible binders to an allosteric site on heat shock protein 70. Journal of Medicinal Chemistry. 57: 1188-207. PMID 24548207 DOI: 10.1021/Jm401551N  0.336
2013 Simon N, Bochman ML, Seguin S, Brodsky JL, Seibel WL, Schwacha A. Ciprofloxacin is an inhibitor of the Mcm2-7 replicative helicase. Bioscience Reports. 33. PMID 24001138 DOI: 10.1042/Bsr20130083  0.741
2013 Abisambra J, Jinwal UK, Miyata Y, Rogers J, Blair L, Li X, Seguin SP, Wang L, Jin Y, Bacon J, Brady S, Cockman M, Guidi C, Zhang J, Koren J, ... ... Brodsky JL, et al. Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau. Biological Psychiatry. 74: 367-74. PMID 23607970 DOI: 10.1016/J.Biopsych.2013.02.027  0.701
2013 Miyata Y, Li X, Lee HF, Jinwal UK, Srinivasan SR, Seguin SP, Young ZT, Brodsky JL, Dickey CA, Sun D, Gestwicki JE. Synthesis and initial evaluation of YM-08, a blood-brain barrier permeable derivative of the heat shock protein 70 (Hsp70) inhibitor MKT-077, which reduces tau levels. Acs Chemical Neuroscience. 4: 930-9. PMID 23472668 DOI: 10.1021/Cn300210G  0.726
2012 Seguin SP, Ireland AW, Gupta T, Wright CM, Miyata Y, Wipf P, Pipas JM, Gestwicki JE, Brodsky JL. A screen for modulators of large T antigen's ATPase activity uncovers novel inhibitors of Simian Virus 40 and BK virus replication. Antiviral Research. 96: 70-81. PMID 22898086 DOI: 10.1016/J.Antiviral.2012.07.012  0.761
2012 Arora R, Shuda M, Guastafierro A, Feng H, Toptan T, Tolstov Y, Normolle D, Vollmer LL, Vogt A, Dömling A, Brodsky JL, Chang Y, Moore PS. Survivin is a therapeutic target in Merkel cell carcinoma. Science Translational Medicine. 4: 133ra56. PMID 22572880 DOI: 10.1126/Scitranslmed.3003713  0.326
2012 Seguin SP, Evans CW, Nebane-Akah M, McKellip S, Ananthan S, Tower NA, Sosa M, Rasmussen L, White EL, Maki BE, Matharu DS, Golden JE, Aubé J, Brodsky JL, Noah JW. High-throughput screening identifies a bisphenol inhibitor of SV40 large T antigen ATPase activity. Journal of Biomolecular Screening. 17: 194-203. PMID 21948801 DOI: 10.1177/1087057111421630  0.744
2012 Daghestani HN, Zhu G, Johnston PA, Shinde SN, Brodsky JL, Day BW. Characterization of inhibitors of glucocorticoid receptor nuclear translocation: a model of cytoplasmic dynein-mediated cargo transport. Assay and Drug Development Technologies. 10: 46-60. PMID 21919741 DOI: 10.1089/Adt.2010.0367  0.353
2011 Braunstein MJ, Scott SS, Scott CM, Behrman S, Walter P, Wipf P, Coplan JD, Chrico W, Joseph D, Brodsky JL, Batuman O. Antimyeloma Effects of the Heat Shock Protein 70 Molecular Chaperone Inhibitor MAL3-101. Journal of Oncology. 2011: 232037. PMID 21977030 DOI: 10.1155/2011/232037  0.348
2011 Huryn DM, Brodsky JL, Brummond KM, Chambers PG, Eyer B, Ireland AW, Kawasumi M, Laporte MG, Lloyd K, Manteau B, Nghiem P, Quade B, Seguin SP, Wipf P. Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators. Proceedings of the National Academy of Sciences of the United States of America. 108: 6757-62. PMID 21502524 DOI: 10.1073/Pnas.1015251108  0.749
2011 Ahn JH, Luo W, Kim J, Rodina A, Clement CC, Aguirre J, Sun W, Kang Y, Maharaj R, Moulick K, Zatorska D, Kokoszka M, Brodsky JL, Chiosis G. Design of a flexible cell-based assay for the evaluation of heat shock protein 70 expression modulators. Assay and Drug Development Technologies. 9: 236-46. PMID 21133677 DOI: 10.1089/Adt.2010.0327  0.345
2010 Wisén S, Bertelsen EB, Thompson AD, Patury S, Ung P, Chang L, Evans CG, Walter GM, Wipf P, Carlson HA, Brodsky JL, Zuiderweg ER, Gestwicki JE. Binding of a small molecule at a protein-protein interface regulates the chaperone activity of hsp70-hsp40. Acs Chemical Biology. 5: 611-22. PMID 20481474 DOI: 10.1021/Cb1000422  0.322
2009 Haney CM, Schneider C, Beck B, Brodsky JL, Dömling A. Identification of Hsp70 modulators through modeling of the substrate binding domain. Bioorganic & Medicinal Chemistry Letters. 19: 3828-31. PMID 19435667 DOI: 10.1016/J.Bmcl.2009.04.062  0.319
2009 Wright CM, Seguin SP, Fewell SW, Zhang H, Ishwad C, Vats A, Lingwood CA, Wipf P, Fanning E, Pipas JM, Brodsky JL. Inhibition of Simian Virus 40 replication by targeting the molecular chaperone function and ATPase activity of T antigen. Virus Research. 141: 71-80. PMID 19200446 DOI: 10.1016/J.Virusres.2008.12.018  0.752
2009 Patham B, Duffy J, Lane A, Davis RC, Wipf P, Fewell SW, Brodsky JL, Mensa-Wilmot K. Post-translational import of protein into the endoplasmic reticulum of a trypanosome: an in vitro system for discovery of anti-trypanosomal chemical entities. The Biochemical Journal. 419: 507-17. PMID 19196237 DOI: 10.1042/Bj20081787  0.321
2009 Chiang AN, Valderramos JC, Balachandran R, Chovatiya RJ, Mead BP, Schneider C, Bell SL, Klein MG, Huryn DM, Chen XS, Day BW, Fidock DA, Wipf P, Brodsky JL. Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum. Bioorganic & Medicinal Chemistry. 17: 1527-33. PMID 19195901 DOI: 10.1016/J.Bmc.2009.01.024  0.31
2008 Wright CM, Chovatiya RJ, Jameson NE, Turner DM, Zhu G, Werner S, Huryn DM, Pipas JM, Day BW, Wipf P, Brodsky JL. Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation. Bioorganic & Medicinal Chemistry. 16: 3291-301. PMID 18164205 DOI: 10.1016/J.Bmc.2007.12.014  0.313
2008 Braunstein MJ, Scott CM, Behrman S, Walter P, Wipf P, Smith EL, Scott SS, Klueppelberg HU, Brodsky JL, Batuman O. Targeting Hsp70 in Multiple Myeloma Induces Synergistic Cytotoxicity with Inhibitors of the Proteasome and of Hsp90 Blood. 112: 5160-5160. DOI: 10.1182/Blood.V112.11.5160.5160  0.303
2007 Braunstein M, Scott C, Berman S, Walter P, Wipf P, Brodsky J, Batuman O. In Vitro Antimyeloma Effects of Inhibitors of the Heat Shock Protein 70 (Hsp70) Molecular Chaperone. Blood. 110: 1524-1524. DOI: 10.1182/Blood.V110.11.1524.1524  0.308
2006 Brodsky JL, Chiosis G. Hsp70 molecular chaperones: emerging roles in human disease and identification of small molecule modulators. Current Topics in Medicinal Chemistry. 6: 1215-25. PMID 16842158 DOI: 10.2174/156802606777811997  0.318
2004 Fewell SW, Smith CM, Lyon MA, Dumitrescu TP, Wipf P, Day BW, Brodsky JL. Small molecule modulators of endogenous and co-chaperone-stimulated Hsp70 ATPase activity. The Journal of Biological Chemistry. 279: 51131-40. PMID 15448148 DOI: 10.1074/Jbc.M404857200  0.382
2001 Fewell SW, Day BW, Brodsky JL. Identification of an inhibitor of hsc70-mediated protein translocation and ATP hydrolysis. The Journal of Biological Chemistry. 276: 910-4. PMID 11036084 DOI: 10.1074/Jbc.M008535200  0.362
1998 Brodsky JL, Pipas JM. Polyomavirus T antigens: Molecular chaperones for multiprotein complexes Journal of Virology. 72: 5329-5334. PMID 9620985 DOI: 10.1128/Jvi.72.7.5329-5334.1998  0.302
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