Christopher A. Del Negro, Ph.D. - Publications

Affiliations: 
Applied Science College of William and Mary, Williamsburg, VA 
Area:
Respiration, Neurophsiology
Website:
http://people.wm.edu/~cadeln/

62 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Borrus DS, Grover C, Conradi Smith GD, Del Negro CA. Role of synaptic inhibition in the coupling of the respiratory rhythms that underlie eupnea and sigh behaviors. Eneuro. PMID 32393585 DOI: 10.1523/ENEURO.0302-19.2020  0.36
2019 Kallurkar PS, Grover C, Picardo MCD, Del Negro CA. Evaluating the burstlet theory of inspiratory rhythm and pattern generation. Eneuro. PMID 31888961 DOI: 10.1523/ENEURO.0314-19.2019  0.84
2019 Picardo MCD, Sugimura YK, Dorst KE, Kallurkar PS, Akins VT, Ma X, Teruyama R, Guinamard R, Kam K, Saha MS, Del Negro CA. Trpm4 ion channels in pre-Bötzinger complex interneurons are essential for breathing motor pattern but not rhythm. Plos Biology. 17: e2006094. PMID 30789900 DOI: 10.1371/Journal.Pbio.2006094  1
2018 Vann NC, Pham FD, Dorst KE, Del Negro CA. Dbx1 Pre-Bötzinger Complex Interneurons Comprise the Core Inspiratory Oscillator for Breathing in Unanesthetized Adult Mice. Eneuro. 5. PMID 29845107 DOI: 10.1523/ENEURO.0130-18.2018  0.96
2018 Del Negro CA, Funk GD, Feldman JL. Breathing matters. Nature Reviews. Neuroscience. PMID 29740175 DOI: 10.1038/s41583-018-0003-6  1
2018 Phillips WS, Del Negro CA, Rekling JC. Dendritic A-current in Rhythmically Active PreBötzinger Complex Neurons in Organotypic Cultures from Newborn Mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29459371 DOI: 10.1523/JNEUROSCI.3342-17.2018  0.64
2017 Hayes JA, Kottick A, Picardo MCD, Halleran AD, Smith RD, Smith GD, Saha MS, Del Negro CA. Transcriptome of neonatal preBötzinger complex neurones in Dbx1 reporter mice. Scientific Reports. 7: 8669. PMID 28819234 DOI: 10.1038/S41598-017-09418-4  1
2017 Akins VT, Weragalaarachchi K, Picardo MCD, Revill AL, Del Negro CA. Morphology of Dbx1 respiratory neurons in the preBötzinger complex and reticular formation of neonatal mice. Scientific Data. 4: 170097. PMID 28763053 DOI: 10.1038/Sdata.2017.97  0.84
2017 Kottick A, Martin CA, Del Negro CA. Fate mapping neurons and glia derived from Dbx1-expressing progenitors in mouse preBötzinger complex. Physiological Reports. 5. PMID 28611151 DOI: 10.14814/phy2.13300  0.72
2016 Vann NC, Pham FD, Hayes JA, Kottick A, Del Negro CA. Transient Suppression of Dbx1 PreBötzinger Interneurons Disrupts Breathing in Adult Mice. Plos One. 11: e0162418. PMID 27611210 DOI: 10.1371/Journal.Pone.0162418  1
2016 Song H, Hayes JA, Vann NC, Wang X, LaMar MD, Del Negro CA. Functional Interactions between Mammalian Respiratory Rhythmogenic and Premotor Circuitry. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 7223-7233. PMID 27383596 DOI: 10.1523/Jneurosci.0296-16.2016  1
2015 Revill AL, Vann NC, Akins VT, Kottick A, Gray PA, Del Negro CA, Funk GD. Dbx1 precursor cells are a source of inspiratory XII premotoneurons. Elife. 4. PMID 26687006 DOI: 10.7554/Elife.12301  1
2015 Phillips WS, Herly M, Del Negro CA, Rekling JC. ORGANOTYPIC SLICE CULTURES CONTAINING THE PREBÖTZINGER COMPLEX GENERATE RESPIRATORY-LIKE RHYTHMS. Journal of Neurophysiology. jn.00904.2015. PMID 26655824 DOI: 10.1152/jn.00904.2015  0.64
2015 Song H, Hayes JA, Vann NC, Drew LaMar M, Del Negro CA. Mechanisms Leading to Rhythm Cessation in the Respiratory PreBötzinger Complex Due to Piecewise Cumulative Neuronal Deletions(1,2,3). Eneuro. 2. PMID 26465010 DOI: 10.1523/ENEURO.0031-15.2015  1
2015 Kottick A, Del Negro CA. Synaptic Depression Influences Inspiratory-Expiratory Phase Transition in Dbx1 Interneurons of the preBötzinger Complex in Neonatal Mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 11606-11. PMID 26290237 DOI: 10.1523/JNEUROSCI.0351-15.2015  0.72
2015 Kottick A, Del Negro CA. Synaptic depression influences inspiratory–Expiratory phase transition in Dbx1 interneurons of the prebötzinger complex in neonatal mice Journal of Neuroscience. 35: 11606-11611. DOI: 10.1523/JNEUROSCI.0351-15.2015  1
2014 Ruangkittisakul A, Kottick A, Picardo MC, Ballanyi K, Del Negro CA. Identification of the pre-Bötzinger complex inspiratory center in calibrated "sandwich" slices from newborn mice with fluorescent Dbx1 interneurons. Physiological Reports. 2. PMID 25138790 DOI: 10.14814/phy2.12111  0.72
2014 Wang X, Hayes JA, Revill AL, Song H, Kottick A, Vann NC, LaMar MD, Picardo MC, Akins VT, Funk GD, Del Negro CA. Laser ablation of Dbx1 neurons in the pre-Bötzinger complex stops inspiratory rhythm and impairs output in neonatal mice. Elife. 3: e03427. PMID 25027440 DOI: 10.7554/Elife.03427  1
2014 Tupal S, Huang WH, Picardo MC, Ling GY, Del Negro CA, Zoghbi HY, Gray PA. Atoh1-dependent rhombic lip neurons are required for temporal delay between independent respiratory oscillators in embryonic mice. Elife. 3: e02265. PMID 24842997 DOI: 10.7554/Elife.02265  1
2014 Guinamard R, Hof T, Del Negro CA. The TRPM4 channel inhibitor 9-phenanthrol. British Journal of Pharmacology. 171: 1600-13. PMID 24433510 DOI: 10.1111/bph.12582  1
2014 Nordman JC, Phillips WS, Kodama N, Clark SG, Del Negro CA, Kabbani N. Axon targeting of the alpha 7 nicotinic receptor in developing hippocampal neurons by Gprin1 regulates growth. Journal of Neurochemistry. 129: 649-62. PMID 24350810 DOI: 10.1111/Jnc.12641  1
2013 Picardo MC, Weragalaarachchi KT, Akins VT, Del Negro CA. Physiological and morphological properties of Dbx1-derived respiratory neurons in the pre-Botzinger complex of neonatal mice. The Journal of Physiology. 591: 2687-703. PMID 23459755 DOI: 10.1113/jphysiol.2012.250118  1
2013 Wang X, Hayes JA, Picardo MC, Del Negro CA. Automated cell-specific laser detection and ablation of neural circuits in neonatal brain tissue. The Journal of Physiology. 591: 2393-401. PMID 23440965 DOI: 10.1113/Jphysiol.2012.247338  1
2013 Guinamard R, Simard C, Del Negro C. Flufenamic acid as an ion channel modulator Pharmacology and Therapeutics. 138: 272-284. PMID 23356979 DOI: 10.1016/j.pharmthera.2013.01.012  1
2013 Feldman JL, Del Negro CA, Gray PA. Understanding the rhythm of breathing: so near, yet so far. Annual Review of Physiology. 75: 423-52. PMID 23121137 DOI: 10.1146/annurev-physiol-040510-130049  1
2012 Hayes JA, Wang X, Del Negro CA. Cumulative lesioning of respiratory interneurons disrupts and precludes motor rhythms in vitro. Proceedings of the National Academy of Sciences of the United States of America. 109: 8286-91. PMID 22566628 DOI: 10.1073/Pnas.1200912109  1
2011 Del Negro CA. Disparate purinergic modulation of respiration in rats and mice. The Journal of Physiology. 589: 4409-10. PMID 21921138 DOI: 10.1113/jphysiol.2011.217935  1
2011 Del Negro CA, Hayes JA, Rekling JC. Dendritic calcium activity precedes inspiratory bursts in preBotzinger complex neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 1017-22. PMID 21248126 DOI: 10.1523/Jneurosci.4731-10.2011  1
2011 Dunmyre JR, Del Negro CA, Rubin JE. Interactions of persistent sodium and calcium-activated nonspecific cationic currents yield dynamically distinct bursting regimes in a model of respiratory neurons. Journal of Computational Neuroscience. 31: 305-28. PMID 21234794 DOI: 10.1007/S10827-010-0311-Y  1
2010 Krey RA, Goodreau AM, Arnold TB, Del Negro CA. Outward Currents Contributing to Inspiratory Burst Termination in preBötzinger Complex Neurons of Neonatal Mice Studied in Vitro. Frontiers in Neural Circuits. 4: 124. PMID 21151816 DOI: 10.3389/fncir.2010.00124  1
2010 Del Negro CA, Hayes JA, Pace RW, Brush BR, Teruyama R, Feldman JL. Synaptically activated burst-generating conductances may underlie a group-pacemaker mechanism for respiratory rhythm generation in mammals. Progress in Brain Research. 187: 111-36. PMID 21111204 DOI: 10.1016/B978-0-444-53613-6.00008-3  1
2010 Gray PA, Hayes JA, Ling GY, Llona I, Tupal S, Picardo MC, Ross SE, Hirata T, Corbin JG, Eugenín J, Del Negro CA. Developmental origin of preBötzinger complex respiratory neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 14883-95. PMID 21048147 DOI: 10.1523/Jneurosci.4031-10.2010  1
2010 Feldman JL, McCrimmon DR, Mitchell GS, Del Negro CA. Brainstem Respiratory Circuits Encyclopedia of Neuroscience. 463-470. DOI: 10.1016/B978-008045046-9.00169-8  1
2009 Rubin JE, Hayes JA, Mendenhall JL, Del Negro CA. Calcium-activated nonspecific cation current and synaptic depression promote network-dependent burst oscillations. Proceedings of the National Academy of Sciences of the United States of America. 106: 2939-44. PMID 19196976 DOI: 10.1073/Pnas.0808776106  1
2009 Del Negro CA, Kam K, Hayes JA, Feldman JL. Asymmetric control of inspiratory and expiratory phases by excitability in the respiratory network of neonatal mice in vitro. The Journal of Physiology. 587: 1217-31. PMID 19171658 DOI: 10.1113/Jphysiol.2008.164079  1
2008 Pace RW, Del Negro CA. AMPA and metabotropic glutamate receptors cooperatively generate inspiratory-like depolarization in mouse respiratory neurons in vitro. The European Journal of Neuroscience. 28: 2434-42. PMID 19032588 DOI: 10.1111/j.1460-9568.2008.06540.x  1
2008 Del Negro CA, Hayes JA. A 'group pacemaker' mechanism for respiratory rhythm generation. The Journal of Physiology. 586: 2245-6. PMID 18450782 DOI: 10.1113/Jphysiol.2008.153627  1
2008 Hayes JA, Mendenhall JL, Brush BR, Del Negro CA. 4-Aminopyridine-sensitive outward currents in preBötzinger complex neurons influence respiratory rhythm generation in neonatal mice. The Journal of Physiology. 586: 1921-36. PMID 18258659 DOI: 10.1113/Jphysiol.2008.150946  1
2008 Del Negro CA, Pace RW, Hayes JA. What role do pacemakers play in the generation of respiratory rhythm? Advances in Experimental Medicine and Biology. 605: 88-93. PMID 18085252 DOI: 10.1007/978-0-387-73693-8_15  1
2008 Nesse WH, Del Negro CA, Bressloff PC. Oscillation regularity in noise-driven excitable systems with multi-time-scale adaptation Physical Review Letters. 101. DOI: 10.1103/PhysRevLett.101.088101  1
2007 Crowder EA, Saha MS, Pace RW, Zhang H, Prestwich GD, Del Negro CA. Phosphatidylinositol 4,5-bisphosphate regulates inspiratory burst activity in the neonatal mouse preBötzinger complex. The Journal of Physiology. 582: 1047-58. PMID 17599963 DOI: 10.1113/Jphysiol.2007.134577  1
2007 Pace RW, Mackay DD, Feldman JL, Del Negro CA. Inspiratory bursts in the preBötzinger complex depend on a calcium-activated non-specific cation current linked to glutamate receptors in neonatal mice. The Journal of Physiology. 582: 113-25. PMID 17446214 DOI: 10.1113/jphysiol.2007.133660  1
2007 Hayes JA, Del Negro CA. Neurokinin receptor-expressing pre-botzinger complex neurons in neonatal mice studied in vitro. Journal of Neurophysiology. 97: 4215-24. PMID 17409172 DOI: 10.1152/Jn.00228.2007  1
2007 Pace RW, Mackay DD, Feldman JL, Del Negro CA. Role of persistent sodium current in mouse preBötzinger Complex neurons and respiratory rhythm generation. The Journal of Physiology. 580: 485-96. PMID 17272351 DOI: 10.1113/jphysiol.2006.124602  1
2006 Feldman JL, Del Negro CA. Looking for inspiration: new perspectives on respiratory rhythm. Nature Reviews. Neuroscience. 7: 232-42. PMID 16495944 DOI: 10.1038/nrn1871  1
2006 Del Negro CA. The parafacial respiratory group (pFRG)/pre-Botzinger complex (preBotC) is the primary site of respiratory rhythm generation in the mammal [11] Journal of Applied Physiology. 100: 2104. DOI: 10.1152/japplphysiol.00351.2006  1
2005 Del Negro CA, Morgado-Valle C, Hayes JA, Mackay DD, Pace RW, Crowder EA, Feldman JL. Sodium and calcium current-mediated pacemaker neurons and respiratory rhythm generation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 446-53. PMID 15647488 DOI: 10.1523/Jneurosci.2237-04.2005  1
2004 Sekerli M, Del Negro CA, Lee RH, Butera RJ. Estimating action potential thresholds from neuronal time-series: new metrics and evaluation of methodologies. Ieee Transactions On Bio-Medical Engineering. 51: 1665-72. PMID 15376515 DOI: 10.1109/TBME.2004.827531  1
2003 Smith JC, Del Negro CA. Nonlinear Neural Network Dynamics in the Mammalian Respiratory Oscillator Annual International Conference of the Ieee Engineering in Medicine and Biology - Proceedings. 4: 3816-3818.  1
2002 Del Negro CA, Koshiya N, Butera RJ, Smith JC. Persistent sodium current, membrane properties and bursting behavior of pre-bötzinger complex inspiratory neurons in vitro. Journal of Neurophysiology. 88: 2242-50. PMID 12424266 DOI: 10.1152/jn.00081.2002  1
2002 Del Negro CA, Morgado-Valle C, Feldman JL. Respiratory rhythm: an emergent network property? Neuron. 34: 821-30. PMID 12062027 DOI: 10.1016/S0896-6273(02)00712-2  1
2002 Del Negro CA, Wilson CG, Butera RJ, Rigatto H, Smith JC. Periodicity, mixed-mode oscillations, and quasiperiodicity in a rhythm-generating neural network. Biophysical Journal. 82: 206-14. PMID 11751309 DOI: 10.1016/S0006-3495(02)75387-3  1
2001 Del Negro CA, Wilson CG, Butera RJ, Koshiya N, Johnson SM, Smith JC. Unstable breathing rhythms and quasiperiodicity in the pre-Bötzinger complex. Advances in Experimental Medicine and Biology. 499: 133-8. PMID 11729867 DOI: 10.1007/978-1-4615-1375-9_21  1
2001 Wilson CG, Butera RJ, Del Negro CA, Rinzel J, Smith JC. Interfacing computer models with real neurons: respiratory "cyberneurons" created with the dynamic clamp. Advances in Experimental Medicine and Biology. 499: 119-24. PMID 11729865 DOI: 10.1007/978-1-4615-1375-9_19  1
2001 Del Negro CA, Johnson SM, Butera RJ, Smith JC. Models of respiratory rhythm generation in the pre-Bötzinger complex. III. Experimental tests of model predictions. Journal of Neurophysiology. 86: 59-74. PMID 11431488 DOI: 10.1152/Jn.2001.86.1.59  1
2000 Smith JC, Butera RJ, Koshiya N, Del Negro C, Wilson CG, Johnson SM. Respiratory rhythm generation in neonatal and adult mammals: the hybrid pacemaker-network model. Respiration Physiology. 122: 131-47. PMID 10967340 DOI: 10.1016/S0034-5687(00)00155-9  1
1999 Carod-Artal FJ, Vargas AP, Del Negro C. Spastic paraparesis due to long term consumption of wild cassava (Manihot esculenta): A neurotoxic model of motor-neurone disease | Paraparesia espastica por consumo cronico de mandioca silvestre (Manihot esculenta): Un modelo neurotoxico de enfermedad de neurona motora Revista De Neurologia. 29: 610-613. PMID 10599107  1
1999 del Negro CA, Hsiao CF, Chandler SH. Outward currents influencing bursting dynamics in guinea pig trigeminal motoneurons. Journal of Neurophysiology. 81: 1478-85. PMID 10200184 DOI: 10.1152/Jn.1999.81.4.1478  1
1998 Del Negro CA, Chandler SH. Regulation of intrinsic and synaptic properties of neonatal rat trigeminal motoneurons by metabotropic glutamate receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 9216-26. PMID 9801361 DOI: 10.1523/Jneurosci.18-22-09216.1998  1
1998 Del Negro CA, Hsiao CF, Chandler SH, Garfinkel A. Evidence for a novel bursting mechanism in rodent trigeminal neurons. Biophysical Journal. 75: 174-82. PMID 9649377 DOI: 10.1016/S0006-3495(98)77504-6  1
1998 Hsiao CF, Del Negro CA, Trueblood PR, Chandler SH. Ionic basis for serotonin-induced bistable membrane properties in guinea pig trigeminal motoneurons. Journal of Neurophysiology. 79: 2847-56. PMID 9636091 DOI: 10.1152/Jn.1998.79.6.2847  1
1997 Del Negro CA, Chandler SH. Physiological and theoretical analysis of K+ currents controlling discharge in neonatal rat mesencephalic trigeminal neurons. Journal of Neurophysiology. 77: 537-53. PMID 9065827 DOI: 10.1152/Jn.1997.77.2.537  1
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