Ewan C. McNay - Publications

Yale University School of Medicine, New Haven, CT 
Hippocampus, Memory, Glucose, Insulin, Diabetes, Alzheimer's, Brain metabolism

49 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Osborne DM, O'Leary KE, Fitzgerald DP, George AJ, Vidal MM, Anderson BM, McNay EC. Context-dependent memory following recurrent hypoglycaemia in non-diabetic rats is mediated via glucocorticoid signalling in the dorsal hippocampus. Diabetologia. PMID 27681242 DOI: 10.1007/s00125-016-4114-1  1
2016 Osborne DM, Fitzgerald DP, O'Leary KE, Anderson BM, Lee CC, Tessier PM, McNay EC. Intrahippocampal administration of a domain antibody that binds aggregated amyloid-β reverses cognitive deficits produced by diet-induced obesity. Biochimica Et Biophysica Acta. PMID 26970498 DOI: 10.1016/j.bbagen.2016.03.005  1
2015 Pearson-Leary J, Osborne DM, McNay EC. Role of Glia in Stress-Induced Enhancement and Impairment of Memory. Frontiers in Integrative Neuroscience. 9: 63. PMID 26793072 DOI: 10.3389/fnint.2015.00063  1
2015 Osborne DM, Pearson-Leary J, McNay EC. The neuroenergetics of stress hormones in the hippocampus and implications for memory. Frontiers in Neuroscience. 9: 164. PMID 25999811 DOI: 10.3389/fnins.2015.00164  1
2015 McNay E. Recurrent hypoglycemia increases anxiety and amygdala norepinephrine release during subsequent hypoglycemia Frontiers in Endocrinology. 6. DOI: 10.3389/fendo.2015.00175  1
2014 McNay E. Your Brain on Insulin: From Heresy to Dogma Perspectives On Psychological Science. 9: 88-90. DOI: 10.1177/1745691613514058  1
2013 Sandusky LA, Flint RW, McNay EC. Elevated glucose metabolism in the amygdala during an inhibitory avoidance task. Behavioural Brain Research. 245: 83-7. PMID 23416236 DOI: 10.1016/j.bbr.2013.02.006  1
2013 McNay EC, Sandusky LA, Pearson-Leary J. Hippocampal insulin microinjection and in vivo microdialysis during spatial memory testing. Journal of Visualized Experiments : Jove. e4451. PMID 23354340 DOI: 10.3791/4451  1
2013 Moy GA, McNay EC. Caffeine prevents weight gain and cognitive impairment caused by a high-fat diet while elevating hippocampal BDNF. Physiology & Behavior. 109: 69-74. PMID 23220362 DOI: 10.1016/j.physbeh.2012.11.008  1
2013 McNay EC, Teske JA, Kotz CM, Dunn-Meynell A, Levin BE, McCrimmon RJ, Sherwin RS. Long-term, intermittent, insulin-induced hypoglycemia produces marked obesity without hyperphagia or insulin resistance: a model for weight gain with intensive insulin therapy. American Journal of Physiology. Endocrinology and Metabolism. 304: E131-8. PMID 23169787 DOI: 10.1152/ajpendo.00262.2012  1
2012 Jahagirdar V, Ramcharitar J, Cotero VE, McNay EC. Moderate Recurrent Hypoglycemia Markedly Impairs Set-Shifting Ability in a Rodent Model: Cognitive and Neurochemical Effects. The Open Diabetes Journal. 5: 1-7. PMID 24403983 DOI: 10.2174/1876524601205010001  1
2012 Sandusky LA, Flint RW, McNay EC. Effects of the protein synthesis inhibitor cycloheximide on anxiety-like extinction behavior in an animal model of post-traumatic stress. Behavioural Brain Research. 231: 208-12. PMID 22465354 DOI: 10.1016/j.bbr.2012.03.019  1
2012 Jahagirdar V, McNay EC. Thyroid hormone's role in regulating brain glucose metabolism and potentially modulating hippocampal cognitive processes. Metabolic Brain Disease. 27: 101-11. PMID 22437199 DOI: 10.1007/s11011-012-9291-0  1
2012 Pearson-Leary J, McNay EC. Intrahippocampal administration of amyloid-β(1-42) oligomers acutely impairs spatial working memory, insulin signaling, and hippocampal metabolism. Journal of Alzheimer's Disease : Jad. 30: 413-22. PMID 22430529 DOI: 10.3233/JAD-2012-112192  1
2011 McNay EC, Recknagel AK. Reprint of: 'Brain insulin signaling: A key component of cognitive processes and a potential basis for cognitive impairment in type 2 diabetes'. Neurobiology of Learning and Memory. 96: 517-28. PMID 22085799 DOI: 10.1016/j.nlm.2011.11.001  1
2011 Alavian KN, Li H, Collis L, Bonanni L, Zeng L, Sacchetti S, Lazrove E, Nabili P, Flaherty B, Graham M, Chen Y, Messerli SM, Mariggio MA, Rahner C, McNay E, et al. Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase. Nature Cell Biology. 13: 1224-33. PMID 21926988 DOI: 10.1038/ncb2330  1
2011 McNay EC, Recknagel AK. Brain insulin signaling: a key component of cognitive processes and a potential basis for cognitive impairment in type 2 diabetes. Neurobiology of Learning and Memory. 96: 432-42. PMID 21907815 DOI: 10.1016/j.nlm.2011.08.005  1
2011 Alavian KN, Li H, Collis L, Bonanni L, Zeng L, Sacchetti S, Lazrove E, Nabili P, Flaherty B, Graham M, Chen Y, Messerli SM, Mariggio MA, Rahner C, McNay E, et al. Bcl-x L regulates metabolic efficiency of neurons through interaction with the mitochondrial F 1 F O ATP synthase Nature Cell Biology. 13: 1383. DOI: 10.1038/ncb2369  1
2010 Shoup-Knox ML, Gallup AC, Gallup GG, McNay EC. Yawning and stretching predict brain temperature changes in rats: support for the thermoregulatory hypothesis. Frontiers in Evolutionary Neuroscience. 2: 108. PMID 21031034 DOI: 10.3389/fnevo.2010.00108  1
2010 Paranjape SA, Chan O, Zhu W, Horblitt AM, McNay EC, Cresswell JA, Bogan JS, McCrimmon RJ, Sherwin RS. Influence of insulin in the ventromedial hypothalamus on pancreatic glucagon secretion in vivo. Diabetes. 59: 1521-7. PMID 20299468 DOI: 10.2337/db10-0014  1
2010 McNay EC, Ong CT, McCrimmon RJ, Cresswell J, Bogan JS, Sherwin RS. Hippocampal memory processes are modulated by insulin and high-fat-induced insulin resistance. Neurobiology of Learning and Memory. 93: 546-53. PMID 20176121 DOI: 10.1016/j.nlm.2010.02.002  1
2010 McNay EC, Cotero VE. Mini-review: impact of recurrent hypoglycemia on cognitive and brain function. Physiology & Behavior. 100: 234-8. PMID 20096711 DOI: 10.1016/j.physbeh.2010.01.004  1
2009 Fan X, Ding Y, Brown S, Zhou L, Shaw M, Vella MC, Cheng H, McNay EC, Sherwin RS, McCrimmon RJ. Hypothalamic AMP-activated protein kinase activation with AICAR amplifies counterregulatory responses to hypoglycemia in a rodent model of type 1 diabetes. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 296: R1702-8. PMID 19357294 DOI: 10.1152/ajpregu.90600.2008  1
2009 Page KA, Williamson A, Yu N, McNay EC, Dzuira J, McCrimmon RJ, Sherwin RS. Medium-chain fatty acids improve cognitive function in intensively treated type 1 diabetic patients and support in vitro synaptic transmission during acute hypoglycemia. Diabetes. 58: 1237-44. PMID 19223595 DOI: 10.2337/db08-1557  1
2008 Li H, Chen Y, Jones AF, Sanger RH, Collis LP, Flannery R, McNay EC, Yu T, Schwarzenbacher R, Bossy B, Bossy-Wetzel E, Bennett MV, Pypaert M, Hickman JA, Smith PJ, et al. Bcl-xL induces Drp1-dependent synapse formation in cultured hippocampal neurons. Proceedings of the National Academy of Sciences of the United States of America. 105: 2169-74. PMID 18250306 DOI: 10.1073/pnas.0711647105  1
2008 Herzog RI, Chan O, Yu S, Dziura J, McNay EC, Sherwin RS. Effect of acute and recurrent hypoglycemia on changes in brain glycogen concentration. Endocrinology. 149: 1499-504. PMID 18187548 DOI: 10.1210/en.2007-1252  1
2008 McCrimmon RJ, Shaw M, Fan X, Cheng H, Ding Y, Vella MC, Zhou L, McNay EC, Sherwin RS. Key role for AMP-activated protein kinase in the ventromedial hypothalamus in regulating counterregulatory hormone responses to acute hypoglycemia. Diabetes. 57: 444-50. PMID 17977955 DOI: 10.2337/db07-0837  1
2007 McNay EC. Insulin and ghrelin: peripheral hormones modulating memory and hippocampal function. Current Opinion in Pharmacology. 7: 628-32. PMID 18023257 DOI: 10.1016/j.coph.2007.10.009  1
2006 McCrimmon RJ, Song Z, Cheng H, McNay EC, Weikart-Yeckel C, Fan X, Routh VH, Sherwin RS. Corticotrophin-releasing factor receptors within the ventromedial hypothalamus regulate hypoglycemia-induced hormonal counterregulation. The Journal of Clinical Investigation. 116: 1723-30. PMID 16741581 DOI: 10.1172/JCI27775  1
2006 McCrimmon RJ, Fan X, Cheng H, McNay E, Chan O, Shaw M, Ding Y, Zhu W, Sherwin RS. Activation of AMP-activated protein kinase within the ventromedial hypothalamus amplifies counterregulatory hormone responses in rats with defective counterregulation. Diabetes. 55: 1755-60. PMID 16731839 DOI: 10.2337/db05-1359  1
2006 McNay EC, Williamson A, McCrimmon RJ, Sherwin RS. Cognitive and neural hippocampal effects of long-term moderate recurrent hypoglycemia. Diabetes. 55: 1088-95. PMID 16567533 DOI: 10.2337/diabetes.55.04.06.db05-1314  1
2006 Diano S, Farr SA, Benoit SC, McNay EC, da Silva I, Horvath B, Gaskin FS, Nonaka N, Jaeger LB, Banks WA, Morley JE, Pinto S, Sherwin RS, Xu L, Yamada KA, et al. Ghrelin controls hippocampal spine synapse density and memory performance. Nature Neuroscience. 9: 381-8. PMID 16491079 DOI: 10.1038/nn1656  1
2006 McNay EC, Canal CE, Sherwin RS, Gold PE. Modulation of memory with septal injections of morphine and glucose: effects on extracellular glucose levels in the hippocampus. Physiology & Behavior. 87: 298-303. PMID 16343563 DOI: 10.1016/j.physbeh.2005.10.016  1
2005 McCrimmon RJ, Evans ML, Fan X, McNay EC, Chan O, Ding Y, Zhu W, Gram DX, Sherwin RS. Activation of ATP-sensitive K+ channels in the ventromedial hypothalamus amplifies counterregulatory hormone responses to hypoglycemia in normal and recurrently hypoglycemic rats. Diabetes. 54: 3169-74. PMID 16249441 DOI: 10.2337/diabetes.54.11.3169  1
2005 McNay EC. The impact of recurrent hypoglycemia on cognitive function in aging. Neurobiology of Aging. 26: 76-9. PMID 16236383 DOI: 10.1016/j.neurobiolaging.2005.08.014  1
2005 Canal CE, McNay EC, Gold PE. Increases in extracellular fluid glucose levels in the rat hippocampus following an anesthetic dose of pentobarbital or ketamine-xylazine: an in vivo microdialysis study. Physiology & Behavior. 84: 245-50. PMID 15708776 DOI: 10.1016/j.physbeh.2004.11.009  1
2004 Evans ML, McCrimmon RJ, Flanagan DE, Keshavarz T, Fan X, McNay EC, Jacob RJ, Sherwin RS. Hypothalamic ATP-sensitive K + channels play a key role in sensing hypoglycemia and triggering counterregulatory epinephrine and glucagon responses. Diabetes. 53: 2542-51. PMID 15448082 DOI: 10.2337/diabetes.53.10.2542  1
2004 McNay EC, Sherwin RS. Effect of recurrent hypoglycemia on spatial cognition and cognitive metabolism in normal and diabetic rats. Diabetes. 53: 418-25. PMID 14747293 DOI: 10.2337/diabetes.53.2.418  1
2004 McNay EC, Sherwin RS. From artificial cerebro-spinal fluid (aCSF) to artificial extracellular fluid (aECF): microdialysis perfusate composition effects on in vivo brain ECF glucose measurements. Journal of Neuroscience Methods. 132: 35-43. PMID 14687673 DOI: 10.1016/j.jneumeth.2003.08.014  1
2003 McCrimmon RJ, Jacob RJ, Fan X, McNay EC, Sherwin RS. Effects of recurrent antecedent hypoglycaemia and chronic hyperglycaemia on brainstem extra-cellular glucose concentrations during acute hypoglycaemia in conscious diabetic BB rats. Diabetologia. 46: 1658-61. PMID 14600813 DOI: 10.1007/s00125-003-1231-4  1
2002 McNay EC, Gold PE. Food for thought: fluctuations in brain extracellular glucose provide insight into the mechanisms of memory modulation. Behavioral and Cognitive Neuroscience Reviews. 1: 264-80. PMID 17712984 DOI: 10.1177/1534582302238337  1
2002 Moyer JR, McNay EC, Brown TH. Three classes of pyramidal neurons in layer V of rat perirhinal cortex. Hippocampus. 12: 218-34. PMID 12004792 DOI: 10.1002/hipo.1110  1
2001 McNay EC, McCarty RC, Gold PE. Fluctuations in brain glucose concentration during behavioral testing: dissociations between brain areas and between brain and blood. Neurobiology of Learning and Memory. 75: 325-37. PMID 11300738 DOI: 10.1006/nlme.2000.3976  1
2001 McNay EC, Gold PE. Age-related differences in hippocampal extracellular fluid glucose concentration during behavioral testing and following systemic glucose administration. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 56: B66-71. PMID 11213269  1
2000 McNay EC, Fries TM, Gold PE. Decreases in rat extracellular hippocampal glucose concentration associated with cognitive demand during a spatial task. Proceedings of the National Academy of Sciences of the United States of America. 97: 2881-5. PMID 10706633 DOI: 10.1073/pnas.050583697  1
1999 Sechi G, DeRiu P, McNay E, Gold P. Extracellular glucose concentrations in the brain (multiple letters) Journal of Neurochemistry. 73: 2222-2223. PMID 10537084  1
1999 McNay EC, Gold PE. Extracellular glucose concentrations in the rat hippocampus measured by zero-net-flux: effects of microdialysis flow rate, strain, and age. Journal of Neurochemistry. 72: 785-90. PMID 9930754 DOI: 10.1046/j.1471-4159.1999.720785.x  1
1998 McNay EC, Willingham DB. Deficit in learning of a motor skill requiring strategy, but not of perceptuomotor recalibration, with aging. Learning & Memory (Cold Spring Harbor, N.Y.). 4: 411-20. PMID 10701880  1
1998 McNay EC, Gold PE. Memory modulation across neural systems: intra-amygdala glucose reverses deficits caused by intraseptal morphine on a spatial task but not on an aversive task. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 3853-8. PMID 9570814  1
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