Mete Civelek, Ph.D. - Publications

Affiliations: 
2008 University of Pennsylvania, Philadelphia, PA, United States 
Area:
Biomedical Engineering, Cell Biology, Animal Pathology Agriculture

42 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Krause MD, Huang RT, Wu D, Shentu TP, Harrison DL, Whalen MB, Stolze LK, Di Rienzo A, Moskowitz IP, Civelek M, Romanoski CE, Fang Y. Genetic variant at coronary artery disease and ischemic stroke locus 1p32.2 regulates endothelial responses to hemodynamics. Proceedings of the National Academy of Sciences of the United States of America. PMID 30429326 DOI: 10.1073/Pnas.1810568115  0.48
2017 Wu D, Huang RT, Hamanaka RB, Krause MD, Oh MJ, Kuo CH, Nigdelioglu R, Meliton AY, Witt L, Dai G, Civelek M, Prabhakar NR, Fang Y, Mutlu GM. HIF-1α is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium. Elife. 6. PMID 28556776 DOI: 10.7554/Elife.25217  0.48
2017 Wu D, Huang R, Hamanaka RB, Krause M, Oh M, Kuo C, Nigdelioglu R, Meliton AY, Witt L, Dai G, Civelek M, Prabhakar NR, Fang Y, Mutlu GM. Author response: HIF-1α is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium Elife. DOI: 10.7554/Elife.25217.045  0.48
2016 Dennis J, Truong V, Aïssi D, Medina-Rivera A, Blankenberg S, Germain M, Lemire M, Antounians L, Civelek M, Schnabel R, Wells P, Wilson MD, Morange PE, Trégouët DA, Gagnon F. Genetic variation 25.1 Mb upstream of tissue factor pathway inhibitor is associated with TFPI plasma levels and venous thromboembolism. Journal of Thrombosis and Haemostasis : Jth. PMID 27490645 DOI: 10.1111/Jth.13431  0.96
2016 Kojima Y, Volkmer JP, McKenna K, Civelek M, Lusis AJ, Miller CL, Direnzo D, Nanda V, Ye J, Connolly AJ, Schadt EE, Quertermous T, Betancur P, Maegdefessel L, Matic LP, et al. CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis. Nature. PMID 27437576 DOI: 10.1038/Nature18935  0.96
2016 Talukdar HA, Foroughi Asl H, Jain RK, Ermel R, Ruusalepp A, Franzén O, Kidd BA, Readhead B, Giannarelli C, Kovacic JC, Ivert T, Dudley JT, Civelek M, Lusis AJ, Schadt EE, et al. Cross-Tissue Regulatory Gene Networks in Coronary Artery Disease. Cell Systems. 2: 196-208. PMID 27135365 DOI: 10.1016/J.Cels.2016.02.002  0.96
2016 Lusis AJ, Seldin M, Allayee H, Bennett BJ, Civelek M, Davis RC, Eskin E, Farber C, Hui ST, Mehrabian M, Norheim F, Pan C, Parks B, Rau C, Smith DJ, et al. The Hybrid Mouse Diversity Panel: A Resource for Systems Genetics Analyses of Metabolic and Cardiovascular Traits. Journal of Lipid Research. PMID 27099397 DOI: 10.1194/Jlr.R066944  0.96
2015 Roman TS, Marvelle AF, Fogarty MP, Vadlamudi S, Gonzalez AJ, Buchkovich ML, Huyghe JR, Fuchsberger C, Jackson AU, Wu Y, Civelek M, Lusis AJ, Gaulton KJ, Sethupathy P, Kangas AJ, et al. Multiple Hepatic Regulatory Variants at the GALNT2 GWAS Locus Associated with High-Density Lipoprotein Cholesterol. American Journal of Human Genetics. 97: 801-15. PMID 26637976 DOI: 10.1016/J.Ajhg.2015.10.016  0.96
2015 Briot A, Civelek M, Seki A, Hoi K, Mack JJ, Lee SD, Kim J, Hong C, Yu J, Fishbein GA, Vakili L, Fogelman AM, Fishbein MC, Lusis AJ, Tontonoz P, et al. Endothelial NOTCH1 is suppressed by circulating lipids and antagonizes inflammation during atherosclerosis. The Journal of Experimental Medicine. PMID 26552708 DOI: 10.1084/Jem.20150603  0.96
2015 Brænne I, Civelek M, Vilne B, Di Narzo A, Johnson AD, Zhao Y, Reiz B, Codoni V, Webb TR, Foroughi Asl H, Hamby SE, Zeng L, Trégouët DA, Hao K, Topol EJ, et al. Prediction of Causal Candidate Genes in Coronary Artery Disease Loci. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 26293461 DOI: 10.1161/Atvbaha.115.306108  0.96
2015 Wu C, Huang RT, Kuo CH, Kumar S, Kim CW, Lin YC, Chen YJ, Birukova A, Birukov KG, Dulin N, Civelek M, Lusis AJ, Loyer X, Tedgui A, Dai G, et al. Mechano-Sensitive PPAP2B Regulates Endothelial Responses to Athero-Relevant Hemodynamic Forces. Circulation Research. PMID 26034042 DOI: 10.1161/Circresaha.117.306457  0.96
2015 Kenagy RD, Civelek M, Kikuchi S, Chen L, Grieff A, Sobel M, Lusis AJ, Clowes AW. Scavenger receptor class A member 5 (SCARA5) and suprabasin (SBSN) are hub genes of coexpression network modules associated with peripheral vein graft patency. Journal of Vascular Surgery. PMID 25935274 DOI: 10.1016/J.Jvs.2014.12.052  0.96
2015 Germain M, Chasman DI, de Haan H, Tang W, Lindström S, Weng LC, de Andrade M, de Visser MC, Wiggins KL, Suchon P, Saut N, Smadja DM, Le Gal G, van Hylckama Vlieg A, Di Narzo A, ... ... Civelek M, et al. Meta-analysis of 65,734 individuals identifies TSPAN15 and SLC44A2 as two susceptibility loci for venous thromboembolism. American Journal of Human Genetics. 96: 532-42. PMID 25772935 DOI: 10.1016/J.Ajhg.2015.01.019  0.96
2015 Bahn JH, Ahn J, Lin X, Zhang Q, Lee JH, Civelek M, Xiao X. Genomic analysis of ADAR1 binding and its involvement in multiple RNA processing pathways. Nature Communications. 6: 6355. PMID 25751603 DOI: 10.1038/Ncomms7355  0.96
2015 Germain M, Pezzolesi MG, Sandholm N, McKnight AJ, Susztak K, Lajer M, Forsblom C, Marre M, Parving HH, Rossing P, Toppila I, Skupien J, Roussel R, Ko YA, Ledo N, ... ... Civelek M, et al. SORBS1 gene, a new candidate for diabetic nephropathy: results from a multi-stage genome-wide association study in patients with type 1 diabetes. Diabetologia. 58: 543-8. PMID 25476525 DOI: 10.1007/S00125-014-3459-6  0.96
2015 Romay MC, Che N, Becker SN, Pouldar D, Hagopian R, Xiao X, Lusis AJ, Berliner JA, Civelek M. Regulation of NF-κB signaling by oxidized glycerophospholipid and IL-1β induced miRs-21-3p and -27a-5p in human aortic endothelial cells. Journal of Lipid Research. 56: 38-50. PMID 25327529 DOI: 10.1194/Jlr.M052670  0.96
2015 Soccio RE, Chen ER, Rajapurkar SR, Safabakhsh P, Marinis JM, Dispirito JR, Emmett MJ, Briggs ER, Fang B, Everett LJ, Lim HW, Won KJ, Steger DJ, Wu Y, Civelek M, et al. Genetic Variation Determines PPARγ Function and Anti-diabetic Drug Response in Vivo Cell. 162: 33-44. DOI: 10.1016/j.cell.2015.06.025  0.96
2014 Civelek M, Lusis AJ. From hairballs to an understanding of transendothelial migration of monocytes in atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 34: 1809-10. PMID 25142882 DOI: 10.1161/Atvbaha.114.304151  0.96
2014 Mäkinen VP, Civelek M, Meng Q, Zhang B, Zhu J, Levian C, Huan T, Segrè AV, Ghosh S, Vivar J, Nikpay M, Stewart AF, Nelson CP, Willenborg C, Erdmann J, et al. Integrative genomics reveals novel molecular pathways and gene networks for coronary artery disease. Plos Genetics. 10: e1004502. PMID 25033284 DOI: 10.1371/Journal.Pgen.1004502  0.96
2014 Iatan I, Choi HY, Ruel I, Reddy MV, Kil H, Lee J, Odeh MA, Salah Z, Abu-Remaileh M, Weissglas-Volkov D, Nikkola E, Civelek M, Awan Z, Croce CM, Aqeilan RI, et al. The WWOX gene modulates high-density lipoprotein and lipid metabolism. Circulation. Cardiovascular Genetics. 7: 491-504. PMID 24871327 DOI: 10.1161/Circgenetics.113.000248  0.96
2014 Civelek M, Lusis AJ. Systems genetics approaches to understand complex traits. Nature Reviews. Genetics. 15: 34-48. PMID 24296534 DOI: 10.1038/Nrg3575  0.96
2013 Erbilgin A, Civelek M, Romanoski CE, Pan C, Hagopian R, Berliner JA, Lusis AJ. Identification of CAD candidate genes in GWAS loci and their expression in vascular cells. Journal of Lipid Research. 54: 1894-905. PMID 23667179 DOI: 10.1194/Jlr.M037085  0.96
2013 Davies PF, Civelek M, Fang Y, Fleming I. The atherosusceptible endothelium: endothelial phenotypes in complex haemodynamic shear stress regions in vivo. Cardiovascular Research. 99: 315-27. PMID 23619421 DOI: 10.1093/Cvr/Cvt101  0.96
2013 Civelek M, Hagopian R, Pan C, Che N, Yang WP, Kayne PS, Saleem NK, Cederberg H, Kuusisto J, Gargalovic PS, Kirchgessner TG, Laakso M, Lusis AJ. Genetic regulation of human adipose microRNA expression and its consequences for metabolic traits. Human Molecular Genetics. 22: 3023-37. PMID 23562819 DOI: 10.1093/Hmg/Ddt159  0.96
2013 Mahendran Y, Vangipurapu J, Cederberg H, Stancáková A, Pihlajamäki J, Soininen P, Kangas AJ, Paananen J, Civelek M, Saleem NK, Pajukanta P, Lusis AJ, Bonnycastle LL, Morken MA, Collins FS, et al. Association of ketone body levels with hyperglycemia and type 2 diabetes in 9,398 Finnish men. Diabetes. 62: 3618-26. PMID 23557707 DOI: 10.2337/Db12-1363  0.96
2013 de Aguiar Vallim TQ, Tarling EJ, Kim T, Civelek M, Baldán Á, Esau C, Edwards PA. MicroRNA-144 regulates hepatic ATP binding cassette transporter A1 and plasma high-density lipoprotein after activation of the nuclear receptor farnesoid X receptor. Circulation Research. 112: 1602-12. PMID 23519696 DOI: 10.1161/Circresaha.112.300648  0.96
2013 Parks BW, Nam E, Org E, Kostem E, Norheim F, Hui ST, Pan C, Civelek M, Rau CD, Bennett BJ, Mehrabian M, Ursell LK, He A, Castellani LW, Zinker B, et al. Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice. Cell Metabolism. 17: 141-52. PMID 23312289 DOI: 10.1016/J.Cmet.2012.12.007  0.96
2012 Haas BE, Horvath S, Pietiläinen KH, Cantor RM, Nikkola E, Weissglas-Volkov D, Rissanen A, Civelek M, Cruz-Bautista I, Riba L, Kuusisto J, Kaprio J, Tusie-Luna T, Laakso M, Aguilar-Salinas CA, et al. Adipose co-expression networks across Finns and Mexicans identify novel triglyceride-associated genes. Bmc Medical Genomics. 5: 61. PMID 23217153 DOI: 10.1186/1755-8794-5-61  0.96
2012 Kim JB, Deluna A, Mungrue IN, Vu C, Pouldar D, Civelek M, Orozco L, Wu J, Wang X, Charugundla S, Castellani LW, Rusek M, Jakubowski H, Jakobowski H, Lusis AJ. Effect of 9p21.3 coronary artery disease locus neighboring genes on atherosclerosis in mice. Circulation. 126: 1896-906. PMID 22952318 DOI: 10.1161/Circulationaha.111.064881  0.96
2012 Ghazalpour A, Rau CD, Farber CR, Bennett BJ, Orozco LD, van Nas A, Pan C, Allayee H, Beaven SW, Civelek M, Davis RC, Drake TA, Friedman RA, Furlotte N, Hui ST, et al. Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 23: 680-92. PMID 22892838 DOI: 10.1007/S00335-012-9411-5  0.96
2012 Stancáková A, Civelek M, Saleem NK, Soininen P, Kangas AJ, Cederberg H, Paananen J, Pihlajamäki J, Bonnycastle LL, Morken MA, Boehnke M, Pajukanta P, Lusis AJ, Collins FS, Kuusisto J, et al. Hyperglycemia and a common variant of GCKR are associated with the levels of eight amino acids in 9,369 Finnish men. Diabetes. 61: 1895-902. PMID 22553379 DOI: 10.2337/Db11-1378  0.96
2011 Romanoski CE, Che N, Yin F, Mai N, Pouldar D, Civelek M, Pan C, Lee S, Vakili L, Yang WP, Kayne P, Mungrue IN, Araujo JA, Berliner JA, Lusis AJ. Network for activation of human endothelial cells by oxidized phospholipids: a critical role of heme oxygenase 1. Circulation Research. 109: e27-41. PMID 21737788 DOI: 10.1161/Circresaha.111.241869  0.96
2011 Civelek M, Lusis AJ. Conducting the metabolic syndrome orchestra. Nature Genetics. 43: 506-8. PMID 21614088 DOI: 10.1038/Ng.842  0.96
2011 Civelek M, Manduchi E, Riley RJ, Stoeckert CJ, Davies PF. Coronary artery endothelial transcriptome in vivo: identification of endoplasmic reticulum stress and enhanced reactive oxygen species by gene connectivity network analysis. Circulation. Cardiovascular Genetics. 4: 243-52. PMID 21493819 DOI: 10.1161/Circgenetics.110.958926  0.96
2011 Civelek M, Manduchi E, Grant GR, Stoeckert CJ, Davies PF. Discovery approaches to UPR in athero-susceptible endothelium in vivo. Methods in Enzymology. 489: 109-26. PMID 21266227 DOI: 10.1016/B978-0-12-385116-1.00007-8  0.96
2011 Davies PF, Civelek M. Endoplasmic reticulum stress, redox, and a proinflammatory environment in athero-susceptible endothelium in vivo at sites of complex hemodynamic shear stress. Antioxidants & Redox Signaling. 15: 1427-32. PMID 21126204 DOI: 10.1089/Ars.2010.3741  0.96
2010 Fang Y, Shi C, Manduchi E, Civelek M, Davies PF. MicroRNA-10a regulation of proinflammatory phenotype in athero-susceptible endothelium in vivo and in vitro. Proceedings of the National Academy of Sciences of the United States of America. 107: 13450-5. PMID 20624982 DOI: 10.1073/Pnas.1002120107  0.96
2010 Davies PF, Civelek M, Fang Y, Guerraty MA, Passerini AG. Endothelial heterogeneity associated with regional athero-susceptibility and adaptation to disturbed blood flow in vivo. Seminars in Thrombosis and Hemostasis. 36: 265-75. PMID 20533180 DOI: 10.1055/S-0030-1253449  0.96
2010 Civelek M, Grant GR, Irolla CR, Shi C, Riley RJ, Chiesa OA, Stoeckert CJ, Karanian JW, Pritchard WF, Davies PF. Prelesional arterial endothelial phenotypes in hypercholesterolemia: universal ABCA1 upregulation contrasts with region-specific gene expression in vivo. American Journal of Physiology. Heart and Circulatory Physiology. 298: H163-70. PMID 19897713 DOI: 10.1152/Ajpheart.00652.2009  0.96
2009 Civelek M, Manduchi E, Riley RJ, Stoeckert CJ, Davies PF. Chronic endoplasmic reticulum stress activates unfolded protein response in arterial endothelium in regions of susceptibility to atherosclerosis. Circulation Research. 105: 453-61. PMID 19661457 DOI: 10.1161/Circresaha.109.203711  0.96
2002 Civelek M, Ainslie K, Garanich JS, Tarbell JM. Smooth muscle cells contract in response to fluid flow via a Ca2+-independent signaling mechanism. Journal of Applied Physiology (Bethesda, Md. : 1985). 93: 1907-17. PMID 12391063 DOI: 10.1152/Japplphysiol.00988.2001  0.96
2002 Sharma R, Yellowley CE, Civelek M, Ainslie K, Hodgson L, Tarbell JM, Donahue HJ. Intracellular calcium changes in rat aortic smooth muscle cells in response to fluid flow. Annals of Biomedical Engineering. 30: 371-8. PMID 12051621 DOI: 10.1114/1.1470179  0.96
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