Year |
Citation |
Score |
2020 |
Ferl GZ, Fuji RN, Atwal JK, Sun T, Ramanujan S, Quartino AL. Mechanistic Modeling of Soluble Aβ Dynamics and Target Engagement in the Brain by Anti-Aβ mAbs in Alzheimer's Disease. Current Alzheimer Research. PMID 32116192 DOI: 10.2174/1567205017666200302122307 |
0.319 |
|
2019 |
Meilandt WJ, Maloney JA, Imperio J, Lalehzadeh G, Earr T, Crowell S, Bainbridge TW, Lu Y, Ernst JA, Fuji RN, Atwal JK. Characterization of the selective in vitro and in vivo binding properties of crenezumab to oligomeric Aβ. Alzheimer's Research & Therapy. 11: 97. PMID 31787113 DOI: 10.1186/S13195-019-0553-5 |
0.323 |
|
2017 |
Ferl GZ, Fuji RN, Atwal J, Ramanujan S, Quartino A. [P1-109]: MATHEMATICAL MODEL OF AMYLOID BETA (Aβ) DYNAMICS TO ASSESS TARGET ENGAGEMENT OF SOLUBLE Aβ OLIGOMERS BY CRENEZUMAB IN THE ALZHEIMER's DISEASE BRAIN Alzheimer's & Dementia. 13: P282-P282. DOI: 10.1016/J.Jalz.2017.06.176 |
0.336 |
|
2016 |
Ultsch M, Li B, Maurer T, Mathieu M, Adolfsson O, Muhs A, Pfeifer A, Pihlgren M, Bainbridge TW, Reichelt M, Ernst JA, Eigenbrot C, Fuh G, Atwal JK, Watts RJ, et al. Structure of Crenezumab Complex with Aβ Shows Loss of β-Hairpin. Scientific Reports. 6: 39374. PMID 27996029 DOI: 10.1038/Srep39374 |
0.309 |
|
2016 |
Lee SH, Le Pichon CE, Adolfsson O, Gafner V, Pihlgren M, Lin H, Solanoy H, Brendza R, Ngu H, Foreman O, Chan R, Ernst JA, DiCara D, Hotzel I, Srinivasan K, ... ... Atwal J, et al. Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement. Cell Reports. PMID 27475227 DOI: 10.1016/J.Celrep.2016.06.099 |
0.388 |
|
2016 |
Gadkar K, Yadav DB, Zuchero JY, Couch JA, Kanodia J, Kenrick MK, Atwal JK, Dennis MS, Prabhu S, Watts RJ, Joseph SB, Ramanujan S. Mathematical PKPD and safety model of bispecific TfR/BACE1 antibodies for the optimization of antibody uptake in brain. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V. PMID 26820920 DOI: 10.1016/J.Ejpb.2016.01.009 |
0.302 |
|
2015 |
Lee S, Le Pichon C, Adolfsson O, Gafner V, Pihlgren M, Lin H, Solanoy H, Brendza R, Ngu H, Foreman O, Chan R, Ernst J, Dicara D, Hotzel I, Srinivasan K, ... ... Atwal J, et al. P2-054: Tau antibodies lacking effector function minimize inflammatory responses while effectively blocking spread of tau pathology Alzheimer's & Dementia. 11: P503-P504. DOI: 10.1016/J.Jalz.2015.06.591 |
0.355 |
|
2014 |
Wetzel-Smith MK, Hunkapiller J, Bhangale TR, Srinivasan K, Maloney JA, Atwal JK, Sa SM, Yaylaoglu MB, Foreman O, Ortmann W, Rathore N, Hansen DV, Tessier-Lavigne M, Mayeux R, et al. A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death. Nature Medicine. 20: 1452-7. PMID 25419706 DOI: 10.1038/Nm.3736 |
0.408 |
|
2014 |
Yu YJ, Atwal JK, Zhang Y, Tong RK, Wildsmith KR, Tan C, Bien-Ly N, Hersom M, Maloney JA, Meilandt WJ, Bumbaca D, Gadkar K, Hoyte K, Luk W, Lu Y, et al. Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates. Science Translational Medicine. 6: 261ra154. PMID 25378646 DOI: 10.1126/Scitranslmed.3009835 |
0.302 |
|
2014 |
Maloney JA, Bainbridge T, Gustafson A, Zhang S, Kyauk R, Steiner P, van der Brug M, Liu Y, Ernst JA, Watts RJ, Atwal JK. Molecular mechanisms of Alzheimer disease protection by the A673T allele of amyloid precursor protein. The Journal of Biological Chemistry. 289: 30990-1000. PMID 25253696 DOI: 10.1074/Jbc.M114.589069 |
0.341 |
|
2011 |
Yu YJ, Zhang Y, Kenrick M, Hoyte K, Luk W, Lu Y, Atwal J, Elliott JM, Prabhu S, Watts RJ, Dennis MS. Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target. Science Translational Medicine. 3: 84ra44. PMID 21613623 DOI: 10.1126/Scitranslmed.3002230 |
0.314 |
|
2011 |
Atwal JK, Chen Y, Chiu C, Mortensen DL, Meilandt WJ, Liu Y, Heise CE, Hoyte K, Luk W, Lu Y, Peng K, Wu P, Rouge L, Zhang Y, Lazarus RA, et al. A therapeutic antibody targeting BACE1 inhibits amyloid-β production in vivo. Science Translational Medicine. 3: 84ra43. PMID 21613622 DOI: 10.1126/Scitranslmed.3002254 |
0.365 |
|
2009 |
Watts RJ, Chen M, Atwal J, Greve JM, Wu Y, Mortensen DL, Varisco Y, Aldolfsson O, Pihlgren M, Pfeifer A, Muhs A. P3-283: Selection of an anti-Abeta antibody that binds various forms of Abeta and blocks toxicity both in vitro and in vivo Alzheimer's & Dementia. 5: P426-P426. DOI: 10.1016/J.Jalz.2009.04.954 |
0.343 |
|
2008 |
Atwal JK, Pinkston-Gosse J, Syken J, Stawicki S, Wu Y, Shatz C, Tessier-Lavigne M. PirB is a functional receptor for myelin inhibitors of axonal regeneration. Science (New York, N.Y.). 322: 967-70. PMID 18988857 DOI: 10.1126/Science.1161151 |
0.302 |
|
2006 |
Karunakaran DKP, Sadleir KR, Kemal S, Cuddy LK, Watts R, Atwal J, Vassar RJ. P1-163: MOLECULAR MECHANISMS OF THE ALZHEIMER'S RISK GENE UNC5C IN NEURONAL DEATH Alzheimer's & Dementia. 14: P340-P340. DOI: 10.1016/J.Jalz.2018.06.167 |
0.458 |
|
2005 |
Jacobs WB, Govoni G, Ho D, Atwal JK, Barnabe-Heider F, Keyes WM, Mills AA, Miller FD, Kaplan DR. p63 is an essential proapoptotic protein during neural development. Neuron. 48: 743-56. PMID 16337913 DOI: 10.1016/J.Neuron.2005.10.027 |
0.632 |
|
2005 |
Zheng B, Atwal J, Ho C, Case L, He XL, Garcia KC, Steward O, Tessier-Lavigne M. Genetic deletion of the Nogo receptor does not reduce neurite inhibition in vitro or promote corticospinal tract regeneration in vivo. Proceedings of the National Academy of Sciences of the United States of America. 102: 1205-10. PMID 15647357 DOI: 10.1073/Pnas.0409026102 |
0.329 |
|
2003 |
Atwal JK, Singh KK, Tessier-Lavigne M, Miller FD, Kaplan DR. Semaphorin 3F antagonizes neurotrophin-induced phosphatidylinositol 3-kinase and mitogen-activated protein kinase kinase signaling: a mechanism for growth cone collapse. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 7602-9. PMID 12930799 DOI: 10.1523/Jneurosci.23-20-07602.2003 |
0.463 |
|
2000 |
Atwal JK, Massie B, Miller FD, Kaplan DR. The TrkB-Shc site signals neuronal survival and local axon growth via MEK and P13-kinase. Neuron. 27: 265-77. PMID 10985347 DOI: 10.1016/S0896-6273(00)00035-0 |
0.582 |
|
2000 |
Kaplan D, Zirrgiebel U, Atwal J. Center stage for NGF in peripheral (but not central) sensory neuron outgrowth. Neuron. 25: 253-254. PMID 10719878 DOI: 10.1016/S0896-6273(00)80887-9 |
0.381 |
|
1998 |
Aloyz RS, Bamji SX, Pozniak CD, Toma JG, Atwal J, Kaplan DR, Miller FD. p53 is essential for developmental neuron death as regulated by the TrkA and p75 neurotrophin receptors. The Journal of Cell Biology. 143: 1691-703. PMID 9852160 DOI: 10.1083/Jcb.143.6.1691 |
0.574 |
|
1996 |
Slack RS, Belliveau DJ, Rosenberg M, Atwal J, Lochmüller H, Aloyz R, Haghighi A, Lach B, Seth P, Cooper E, Miller FD. Adenovirus-mediated gene transfer of the tumor suppressor, p53, induces apoptosis in postmitotic neurons. The Journal of Cell Biology. 135: 1085-96. PMID 8922388 DOI: 10.1083/Jcb.135.4.1085 |
0.666 |
|
Low-probability matches (unlikely to be authored by this person) |
2017 |
Lo M, Kim HS, Tong RK, Bainbridge TW, Vernes JM, Zhang Y, Lin YL, Chung S, Dennis MS, Zuchero YJ, Watts RJ, Couch JA, Meng YG, Atwal JK, Brezski RJ, et al. Effector attenuating substitutions that maintain antibody stability and reduce toxicity in mice. The Journal of Biological Chemistry. PMID 28077575 DOI: 10.1074/Jbc.M116.767749 |
0.286 |
|
2016 |
Lu Y, Hoyte K, Montgomery WH, Luk W, He D, Meilandt WJ, Yu Zuchero YJ, Atwal JK, Scearce-Levie K, Watts RJ, DeForge LE. Characterization of a sensitive mouse Aβ40 PD biomarker assay for Alzheimer's disease drug development in wild-type mice. Bioanalysis. PMID 27094761 DOI: 10.4155/Bio-2016-0003 |
0.285 |
|
2001 |
Mowla SJ, Farhadi HF, Pareek S, Atwal JK, Morris SJ, Seidah NG, Murphy RA. Biosynthesis and post-translational processing of the precursor to brain-derived neurotrophic factor. The Journal of Biological Chemistry. 276: 12660-6. PMID 11152678 DOI: 10.1074/Jbc.M008104200 |
0.282 |
|
2013 |
Meilandt W, Atwal J, Gadkar K, Hoyte K, Luk W, Lu Y, Watts R, Scearce-Levie K. Modest reductions in BACE1 activity significantly reduce beta-amyloid plaque load and neuroinflammation in a mouse model of Alzheimer's disease Alzheimers & Dementia. 9: 504. DOI: 10.1016/J.Jalz.2013.05.1048 |
0.281 |
|
2005 |
Koprivica V, Cho KS, Park JB, Yiu G, Atwal J, Gore B, Kim JA, Lin E, Tessier-Lavigne M, Chen DF, He Z. EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans. Science (New York, N.Y.). 310: 106-10. PMID 16210539 DOI: 10.1126/Science.1115462 |
0.272 |
|
2012 |
Jonsson T, Atwal JK, Steinberg S, Snaedal J, Jonsson PV, Bjornsson S, Stefansson H, Sulem P, Gudbjartsson D, Maloney J, Hoyte K, Gustafson A, Liu Y, Lu Y, Bhangale T, et al. A mutation in APP protects against Alzheimer's disease and age-related cognitive decline. Nature. 488: 96-9. PMID 22801501 DOI: 10.1038/Nature11283 |
0.271 |
|
2012 |
Adolfsson O, Pihlgren M, Toni N, Varisco Y, Buccarello AL, Antoniello K, Lohmann S, Piorkowska K, Gafner V, Atwal JK, Maloney J, Chen M, Gogineni A, Weimer RM, Mortensen DL, et al. An effector-reduced anti-β-amyloid (Aβ) antibody with unique aβ binding properties promotes neuroprotection and glial engulfment of Aβ. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 9677-89. PMID 22787053 DOI: 10.1523/Jneurosci.4742-11.2012 |
0.26 |
|
2017 |
Bumbaca Yadav D, Maloney JA, Wildsmith KR, Fuji RN, Meilandt WJ, Solanoy H, Lu Y, Peng K, Wilson B, Chan P, Gadkar K, Kosky A, Goo M, Daugherty A, Couch JA, ... ... Atwal JK, et al. Widespread brain distribution and activity following anti-BACE1 intracerebroventricular infusion in nonhuman primates. British Journal of Pharmacology. PMID 28859225 DOI: 10.1111/Bph.14021 |
0.256 |
|
2021 |
Ayalon G, Lee SH, Adolfsson O, Foo-Atkins C, Atwal JK, Blendstrup M, Booler H, Bravo J, Brendza R, Brunstein F, Chan R, Chandra P, Couch JA, Datwani A, Demeule B, et al. Antibody semorinemab reduces tau pathology in a transgenic mouse model and engages tau in patients with Alzheimer's disease. Science Translational Medicine. 13. PMID 33980574 DOI: 10.1126/scitranslmed.abb2639 |
0.247 |
|
2016 |
Ultsch M, Li B, Maurer T, Mathieu M, Adolfsson O, Muhs A, Pfeifer A, Pihlgren M, Bainbridge TW, Reichelt M, Ernst JA, Eigenbrot C, Fuh G, Atwal JK, Watts RJ, et al. Structure of Crenezumab Complex with A beta Shows Loss of beta-Hairpin. Scientific Reports. 6: 39374-39374. DOI: 10.2210/Pdb5Vzx/Pdb |
0.245 |
|
2017 |
Reichelt M, Bainbridge TW, Corpuz R, Lee SH, Ernst JA, Foreman O, Sagolla M, Atwal JK, Ayalon G. Identification and Characterization of Reconstituted α-Synuclein, Amyloid-β and Tau Fibrils by Immunogold Negative Staining Electron Microscopy Microscopy and Microanalysis. 23: 1312-1313. DOI: 10.1017/S143192761700722X |
0.241 |
|
2013 |
Liu X, Wong H, Scearce-Levie K, Watts RJ, Coraggio M, Shin YG, Peng K, Wildsmith KR, Atwal JK, Mango J, Schauer SP, Regal K, Hunt KW, Thomas AA, Siu M, et al. Mechanistic pharmacokinetic-pharmacodynamic modeling of BACE1 inhibition in monkeys: development of a predictive model for amyloid precursor protein processing. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 1319-28. PMID 23584887 DOI: 10.1124/Dmd.112.050864 |
0.233 |
|
2012 |
Meilandt W, Atwal J, Solanoy H, Hoyte K, Luk W, Lu Y, Watts R, Scearce-Levie K. Role of BACE1 and BACE2 in the production of endogenous mouse Aß Alzheimers & Dementia. 8: 193. DOI: 10.1016/J.Jalz.2012.05.528 |
0.23 |
|
2014 |
Bumbaca D, Bumbaca D, Wildsmith K, Fuji R, Scearce-Levie K, Maloney J, Meilandt W, Solanoy H, Lu Y, Peng K, Wilson B, Chan P, Kosky A, Goo M, Daugherty A, ... ... Atwal J, et al. P1-359: WIDESPREAD BRAIN DISTRIBUTION AND ROBUST BACE1 INHIBITION FOLLOWING INTRACEREBROVENTRICULAR INFUSION OF ANTI-BACE1 IN NON-HUMAN PRIMATES Alzheimer's & Dementia. 10: P445-P445. DOI: 10.1016/J.Jalz.2014.05.601 |
0.222 |
|
2022 |
Ramakrishnan V, Friedrich C, Witt C, Sheehan R, Pryor M, Atwal JK, Wildsmith K, Kudrycki K, Lee SH, Mazer N, Hofmann C, Fuji RN, Jin JY, Ramanujan S, Dolton M, et al. Quantitative Systems Pharmacology Model of the Amyloid Pathway in Alzheimer's Disease: Insights into the Therapeutic Mechanisms of Clinical Candidates. Cpt: Pharmacometrics & Systems Pharmacology. PMID 36281062 DOI: 10.1002/psp4.12876 |
0.181 |
|
2016 |
Kanodia JS, Gadkar K, Bumbaca D, Zhang Y, Tong RK, Luk W, Hoyte K, Lu Y, Wildsmith KR, Couch JA, Watts RJ, Dennis MS, Ernst JA, Scearce-Levie K, Atwal JK, et al. Prospective Design of Anti-Transferrin Receptor Bispecific Antibodies for Optimal Delivery into the Human Brain. Cpt: Pharmacometrics & Systems Pharmacology. 5: 283-291. PMID 27299941 DOI: 10.1002/psp4.12081 |
0.152 |
|
2012 |
Chen M, Maloney JA, Kallop DY, Atwal JK, Tam SJ, Baer K, Kissel H, Kaminker JS, Lewcock JW, Weimer RM, Watts RJ. Spatially coordinated kinase signaling regulates local axon degeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 13439-53. PMID 23015435 DOI: 10.1523/Jneurosci.2039-12.2012 |
0.131 |
|
2022 |
Sadekar SS, Bowen M, Cai H, Jamalian S, Rafidi H, Shatz-Binder W, Lafrance-Vanasse J, Chan P, Meilandt WJ, Oldendorp A, Sreedhara A, Daugherty A, Crowell S, Wildsmith KR, Atwal J, et al. Translational approaches for brain delivery of biologics via cerebrospinal fluid. Clinical Pharmacology and Therapeutics. PMID 35064573 DOI: 10.1002/cpt.2531 |
0.101 |
|
1991 |
Kendrick PN, Trim AJ, Atwal JK, Brown PM. Direct gas chromatographic determination of carbaryl residues in honeybees (Apis mellifera L.) using a nitrogen-phosphorus detector with confirmation by formation of a chemical derivative Bulletin of Environmental Contamination and Toxicology. 46: 654-661. PMID 1903992 DOI: 10.1007/BF01689948 |
0.019 |
|
Hide low-probability matches. |