Brian D. Klein, Ph.D. - Publications

Affiliations: 
2003 University of Utah, Salt Lake City, UT 
Area:
Neuroscience Biology, Pharmacology, Audiology, Genetics

17 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Metcalf CS, Klein BD, Smith MD, Ceusters M, Lavreysen H, Pype S, Van Osselaer N, Twyman R, White HS. Potent and selective pharmacodynamic synergy between the metabotropic glutamate receptor subtype 2-positive allosteric modulator JNJ-46356479 and levetiracetam in the mouse 6-Hz (44-mA) model. Epilepsia. PMID 29360159 DOI: 10.1111/epi.14005  0.48
2017 Klein BD, Jacobson CA, Metcalf CS, Smith MD, Wilcox KS, Hampson AJ, Kehne JH. Evaluation of Cannabidiol in Animal Seizure Models by the Epilepsy Therapy Screening Program (ETSP). Neurochemical Research. PMID 28478594 DOI: 10.1007/s11064-017-2287-8  0.32
2017 Metcalf CS, Smith MD, Klein BD, McDougle DR, Zhang L, Bulaj G. Preclinical Analgesic and Safety Evaluation of the GalR2-preferring Analog, NAX 810-2. Neurochemical Research. PMID 28382595 DOI: 10.1007/s11064-017-2229-5  0.4
2017 Metcalf CS, Klein BD, Smith MD, Pruess T, Ceusters M, Lavreysen H, Pype S, Van Osselaer N, Twyman R, White HS. Efficacy of mGlu2 -positive allosteric modulators alone and in combination with levetiracetam in the mouse 6 Hz model of psychomotor seizures. Epilepsia. PMID 28166368 DOI: 10.1111/epi.13659  0.48
2017 Metcalf CS, Klein BD, McDougle DR, Zhang L, Kaufmann D, Bulaj G, White HS. Preclinical evaluation of intravenous NAX 810-2, a novel GalR2-preferring analog, for anticonvulsant efficacy and pharmacokinetics. Epilepsia. PMID 28098336 DOI: 10.1111/epi.13647  0.48
2015 Metcalf CS, Klein BD, McDougle DR, Zhang L, Smith MD, Bulaj G, White HS. Analgesic properties of a peripherally acting and GalR2 receptor-preferring galanin analog in inflammatory, neuropathic, and acute pain models. The Journal of Pharmacology and Experimental Therapeutics. 352: 185-93. PMID 25347995 DOI: 10.1124/jpet.114.219063  0.48
2014 Jequier Gygax M, Klein BD, White HS, Kim M, Galanopoulou AS. Efficacy and tolerability of the galanin analog NAX 5055 in the multiple-hit rat model of symptomatic infantile spasms. Epilepsy Research. 108: 98-108. PMID 24252685 DOI: 10.1016/j.eplepsyres.2013.10.015  0.48
2013 McComsey DF, Smith-Swintosky VL, Parker MH, Brenneman DE, Malatynska E, White HS, Klein BD, Wilcox KS, Milewski ME, Herb M, Finley MF, Liu Y, Lubin ML, Qin N, Reitz AB, et al. Novel, broad-spectrum anticonvulsants containing a sulfamide group: pharmacological properties of (S)-N-[(6-chloro-2,3-dihydrobenzo[1,4]dioxin-2-yl)methyl]sulfamide (JNJ-26489112). Journal of Medicinal Chemistry. 56: 9019-30. PMID 24205976 DOI: 10.1021/jm400894u  0.48
2013 Zhang L, Klein BD, Metcalf CS, Smith MD, McDougle DR, Lee HK, White HS, Bulaj G. Incorporation of monodisperse oligoethyleneglycol amino acids into anticonvulsant analogues of galanin and neuropeptide y provides peripherally acting analgesics. Molecular Pharmaceutics. 10: 574-85. PMID 23259957 DOI: 10.1021/mp300236v  0.48
2013 Green BR, Klein BD, Lee HK, Smith MD, Steve White H, Bulaj G. Cyclic analogs of galanin and neuropeptide Y by hydrocarbon stapling. Bioorganic & Medicinal Chemistry. 21: 303-10. PMID 23176753 DOI: 10.1016/j.bmc.2012.10.026  0.48
2009 White HS, Scholl EA, Klein BD, Flynn SP, Pruess TH, Green BR, Zhang L, Bulaj G. Developing novel antiepileptic drugs: characterization of NAX 5055, a systemically-active galanin analog, in epilepsy models. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 6: 372-80. PMID 19332332 DOI: 10.1016/j.nurt.2009.01.001  0.48
2006 Bulaj G, Zhang MM, Green BR, Fiedler B, Layer RT, Wei S, Nielsen JS, Low SJ, Klein BD, Wagstaff JD, Chicoine L, Harty TP, Terlau H, Yoshikami D, Olivera BM. Synthetic muO-conotoxin MrVIB blocks TTX-resistant sodium channel NaV1.8 and has a long-lasting analgesic activity. Biochemistry. 45: 7404-14. PMID 16752929 DOI: 10.1021/bi060159+  0.48
2005 Klein BD, Fu YH, Ptacek LJ, White HS. Auditory deficits associated with the frings mgr1 (mass1) mutation in mice. Developmental Neuroscience. 27: 321-32. PMID 16137990 DOI: 10.1159/000086712  0.48
2004 Klein BD, Fu YH, Ptacek LJ, White HS. c-Fos immunohistochemical mapping of the audiogenic seizure network and tonotopic neuronal hyperexcitability in the inferior colliculus of the Frings mouse. Epilepsy Research. 62: 13-25. PMID 15519128 DOI: 10.1016/j.eplepsyres.2004.06.007  0.48
2003 Isoherranen N, White HS, Klein BD, Roeder M, Woodhead JH, Schurig V, Yagen B, Bialer M. Pharmacokinetic-pharmacodynamic relationships of (2S,3S)-valnoctamide and its stereoisomer (2R,3S)-valnoctamide in rodent models of epilepsy. Pharmaceutical Research. 20: 1293-301. PMID 12948028 DOI: 10.1023/A:1025069519218  0.48
2001 Barton ME, Klein BD, Wolf HH, White HS. Pharmacological characterization of the 6 Hz psychomotor seizure model of partial epilepsy. Epilepsy Research. 47: 217-27. PMID 11738929 DOI: 10.1016/S0920-1211(01)00302-3  0.48
2000 Klein BD, White HS, Callahan KS. Cytokine and intracellular signaling regulation of tissue factor expression in astrocytes. Neurochemistry International. 36: 441-9. PMID 10733012 DOI: 10.1016/S0197-0186(99)00147-3  0.48
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