Franz Hefti - Publications

Affiliations: 
Rinat, Bishkek, Chuy Province, Kyrgyzstan 

148 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2014 Goure WF, Krafft GA, Jerecic J, Hefti F. Targeting the proper amyloid-beta neuronal toxins: a path forward for Alzheimer's disease immunotherapeutics. Alzheimer's Research & Therapy. 6: 42. PMID 25045405 DOI: 10.1186/alzrt272  0.64
2013 Hefti F, Goure WF, Jerecic J, Iverson KS, Walicke PA, Krafft GA. The case for soluble Aβ oligomers as a drug target in Alzheimer's disease. Trends in Pharmacological Sciences. 34: 261-6. PMID 23582316 DOI: 10.1016/j.tips.2013.03.002  0.64
2012 Naylor MD, Karlawish JH, Arnold SE, Khachaturian AS, Khachaturian ZS, Lee VM, Baumgart M, Banerjee S, Beck C, Blennow K, Brookmeyer R, Brunden KR, Buckwalter KC, Comer M, Covinsky K, ... ... Hefti FF, et al. Advancing Alzheimer's disease diagnosis, treatment, and care: recommendations from the Ware Invitational Summit. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 8: 445-52. PMID 22959699 DOI: 10.1016/j.jalz.2012.08.001  0.64
2012 Choi SR, Schneider JA, Bennett DA, Beach TG, Bedell BJ, Zehntner SP, Krautkramer MJ, Kung HF, Skovronsky DM, Hefti F, Clark CM. Correlation of amyloid PET ligand florbetapir F 18 binding with Aβ aggregation and neuritic plaque deposition in postmortem brain tissue. Alzheimer Disease and Associated Disorders. 26: 8-16. PMID 22354138 DOI: 10.1097/WAD.0b013e31821300bc  0.64
2012 Kablinger AS, Lindner MA, Casso S, Hefti F, DeMuth G, Fox BS, McNair LA, McCarthy BG, Goeders NE. Effects of the combination of metyrapone and oxazepam on cocaine craving and cocaine taking: a double-blind, randomized, placebo-controlled pilot study. Journal of Psychopharmacology (Oxford, England). 26: 973-81. PMID 22236504 DOI: 10.1177/0269881111430745  0.64
2011 Virostko J, Henske J, Vinet L, Lamprianou S, Dai C, Radhika A, Baldwin RM, Ansari MS, Hefti F, Skovronsky D, Kung HF, Herrera PL, Peterson TE, Meda P, Powers AC. Multimodal image coregistration and inducible selective cell ablation to evaluate imaging ligands. Proceedings of the National Academy of Sciences of the United States of America. 108: 20719-24. PMID 22143775 DOI: 10.1073/pnas.1109480108  0.64
2011 Zha Z, Choi SR, Ploessl K, Lieberman BP, Qu W, Hefti F, Mintun M, Skovronsky D, Kung HF. Multidentate (18)F-polypegylated styrylpyridines as imaging agents for Aβ plaques in cerebral amyloid angiopathy (CAA). Journal of Medicinal Chemistry. 54: 8085-98. PMID 22011144 DOI: 10.1021/jm2009106  0.64
2011 Lister-James J, Pontecorvo MJ, Clark C, Joshi AD, Mintun MA, Zhang W, Lim N, Zhuang Z, Golding G, Choi SR, Benedum TE, Kennedy P, Hefti F, Carpenter AP, Kung HF, et al. Florbetapir f-18: a histopathologically validated Beta-amyloid positron emission tomography imaging agent. Seminars in Nuclear Medicine. 41: 300-4. PMID 21624563 DOI: 10.1053/j.semnuclmed.2011.03.001  0.64
2011 Clark CM, Schneider JA, Bedell BJ, Beach TG, Bilker WB, Mintun MA, Pontecorvo MJ, Hefti F, Carpenter AP, Flitter ML, Krautkramer MJ, Kung HF, Coleman RE, Doraiswamy PM, Fleisher AS, et al. Use of florbetapir-PET for imaging beta-amyloid pathology. Jama. 305: 275-83. PMID 21245183 DOI: 10.1001/jama.2010.2008  0.64
2010 Hefti FF, Kung HF, Kilbourn MR, Carpenter AP, Clark CM, Skovronsky DM. 18F-AV-133: A selective VMAT2-binding radiopharmaceutical for PET imaging of dopaminergic neurons Pet Clinics. 5: 75-82. DOI: 10.1016/j.cpet.2010.02.001  0.64
2010 McNeill TH, Davis EJ, Hefti FF, Collier TJ. Neurotransmitters and neurotrophic factors Encyclopedia of Gerontology. 269-276. DOI: 10.1016/B0-12-370870-2/00139-6  0.64
2009 Choi SR, Golding G, Zhuang Z, Zhang W, Lim N, Hefti F, Benedum TE, Kilbourn MR, Skovronsky D, Kung HF. Preclinical properties of 18F-AV-45: a PET agent for Abeta plaques in the brain. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 50: 1887-94. PMID 19837759 DOI: 10.2967/jnumed.109.065284  0.64
2009 Carpenter AP, Pontecorvo MJ, Hefti FF, Skovronsky DM. The use of the exploratory IND in the evaluation and development of 18F-PET radiopharmaceuticals for amyloid imaging in the brain: a review of one company's experience. The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (Aimn) [and] the International Association of Radiopharmacology (Iar), [and] Section of the Society of Radiopharmaceutical Chemistry and Biology. 53: 387-93. PMID 19834448  0.64
2008 Hefti FF. Requirements for a lead compound to become a clinical candidate. Bmc Neuroscience. 9: S7. PMID 19091004 DOI: 10.1186/1471-2202-9-S3-S7  0.64
2006 Hefti FF, Bales R. Regulatory issues in aging pharmacology. Aging Cell. 5: 3-8. PMID 16441837 DOI: 10.1111/j.1474-9726.2006.00193.x  0.64
2006 Hefti FF, Rosenthal A, Walicke PA, Wyatt S, Vergara G, Shelton DL, Davies AM. Novel class of pain drugs based on antagonism of NGF. Trends in Pharmacological Sciences. 27: 85-91. PMID 16376998 DOI: 10.1016/j.tips.2005.12.001  0.64
2004 Grimm J, Mueller A, Hefti F, Rosenthal A. Molecular basis for catecholaminergic neuron diversity. Proceedings of the National Academy of Sciences of the United States of America. 101: 13891-6. PMID 15353588 DOI: 10.1073/pnas.0405340101  0.64
2002 Bilsland J, Roy S, Xanthoudakis S, Nicholson DW, Han Y, Grimm E, Hefti F, Harper SJ. Caspase inhibitors attenuate 1-methyl-4-phenylpyridinium toxicity in primary cultures of mesencephalic dopaminergic neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 2637-49. PMID 11923429  0.64
2001 Wilkie N, Wingrove PB, Bilsland JG, Young L, Harper SJ, Hefti F, Ellis S, Pollack SJ. The non-peptidyl fungal metabolite L-783,281 activates TRK neurotrophin receptors. Journal of Neurochemistry. 78: 1135-45. PMID 11553687 DOI: 10.1046/j.1471-4159.2001.00504.x  0.64
2001 Hefti F. From genes to effective drugs for neurological and psychiatric diseases. Trends in Pharmacological Sciences. 22: 159-60. PMID 11282404 DOI: 10.1016/S0165-6147(00)01673-4  0.64
2000 Harper SJ, Saporito MS, Hewson L, Young L, Smith D, Rigby M, Jackson P, Curtis N, Swain C, Hefti F, Vaught JL, Sirinathsinghji D. CEP-1347 increases ChAT activity in culture and promotes cholinergic neurone survival following fimbria-fornix lesion. Neuroreport. 11: 2271-6. PMID 10923684  0.64
1999 Pollack S, Young L, Bilsland J, Wilkie N, Ellis S, Hefti F, Broughton H, Harper S. The staurosporine-like compound L-753,000 (NB-506) potentiates the neurotrophic effects of neurotrophin-3 by acting selectively at the TrkA receptor. Molecular Pharmacology. 56: 185-95. PMID 10385700  0.64
1999 Harper S, Bilsland J, Young L, Bristow L, Boyce S, Mason G, Rigby M, Hewson L, Smith D, O'Donnell R, O'Connor D, Hill RG, Evans D, Swain C, Williams B, ... Hefti F, et al. Analysis of the neurotrophic effects of GPI-1046 on neuron survival and regeneration in culture and in vivo. Neuroscience. 88: 257-67. PMID 10051205 DOI: 10.1016/S0306-4522(98)00221-8  0.64
1998 Kramer MS, Cutler N, Feighner J, Shrivastava R, Carman J, Sramek JJ, Reines SA, Liu G, Snavely D, Wyatt-Knowles E, Hale JJ, Mills SG, MacCoss M, Swain CJ, Harrison T, ... ... Hefti F, et al. Distinct mechanism for antidepressant activity by blockade of central substance P receptors. Science (New York, N.Y.). 281: 1640-5. PMID 9733503 DOI: 10.1126/science.281.5383.1640  0.64
1998 Qiao X, Chen L, Gao H, Bao S, Hefti F, Thompson RF, Knusel B. Cerebellar brain-derived neurotrophic factor-TrkB defect associated with impairment of eyeblink conditioning in Stargazer mutant mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 6990-9. PMID 9712667  0.64
1998 Venero JL, Hefti F. Regionally specific induction of BDNF and truncated trkB.T1 receptors in the hippocampal formation after intraseptal injection of kainic acid. Brain Research. 790: 270-7. PMID 9593933 DOI: 10.1016/S0006-8993(98)00071-7  0.64
1997 Gao H, Qiao X, Hefti F, Hollyfield JG, Knusel B. Elevated mRNA expression of brain-derived neurotrophic factor in retinal ganglion cell layer after optic nerve injury. Investigative Ophthalmology & Visual Science. 38: 1840-7. PMID 9286274  0.64
1997 Hughes PE, Alexi T, Hefti F, Knusel B. Axotomized septal cholinergic neurons rescued by nerve growth factor or neurotrophin-4/5 fail to express the inducible transcription factor c-Jun. Neuroscience. 78: 1037-49. PMID 9174072 DOI: 10.1016/S0306-4522(96)00623-9  0.64
1997 Knusel B, Gao H, Okazaki T, Yoshida T, Mori N, Hefti F, Kaplan DR. Ligand-induced down-regulation of Trk messenger RNA, protein and tyrosine phosphorylation in rat cortical neurons. Neuroscience. 78: 851-62. PMID 9153663 DOI: 10.1016/S0306-4522(96)00616-1  0.64
1997 Hefti F. Neurotrophic factor therapy--keeping score. Nature Medicine. 3: 497-8. PMID 9142113  0.64
1997 Alexi T, Venero JL, Hefti F. Protective effects of neurotrophin-4/5 and transforming growth factor-alpha on striatal neuronal phenotypic degeneration after excitotoxic lesioning with quinolinic acid. Neuroscience. 78: 73-86. PMID 9135090 DOI: 10.1016/S0306-4522(97)83046-1  0.64
1997 Hefti F. Pharmacology of neurotrophic factors. Annual Review of Pharmacology and Toxicology. 37: 239-67. PMID 9131253 DOI: 10.1146/annurev.pharmtox.37.1.239  0.64
1996 Hefti F, Armanini MP, Beck KD, Caras IW, Chen KS, Godowski PJ, Goodman LJ, Hammonds RG, Mark MR, Moran P, Nishimura MC, Phillips HS, Shih A, Valverde J, Winslow JW. Development of neurotrophic factor therapy for Alzheimer's disease. Ciba Foundation Symposium. 196: 54-63; discussion 63. PMID 8991782  0.64
1996 Chan KM, Lam DT, Pong K, Widmer HR, Hefti F. Neurotrophin-4/5 treatment reduces infarct size in rats with middle cerebral artery occlusion. Neurochemical Research. 21: 763-7. PMID 8873080  0.64
1996 Nikolics K, Hefti F, Thomas GR, Gluckman PD. Trophic factors and their role in the postischemic brain. Advances in Neurology. 71: 389-402; discussion . PMID 8790814  0.64
1996 Beck KD, Irwin I, Valverde J, Brennan TJ, Langston JW, Hefti F. GDNF induces a dystonia-like state in neonatal rats and stimulates dopamine and serotonin synthesis. Neuron. 16: 665-73. PMID 8785063 DOI: 10.1016/S0896-6273(00)80085-9  0.64
1996 Alexi T, Hefti F. Neurotrophin-4/5 selectively protects nigral calbindin-containing neurons in rats with medial forebrain bundle transections. Neuroscience. 72: 911-21. PMID 8735219 DOI: 10.1016/0306-4522(95)00607-9  0.64
1996 Qiao X, Hughes PE, Venero JL, Dugich-Djordjevic MM, Nichols NR, Hefti F, Knusel B. NT-4/5 protects against adrenalectomy-induced apoptosis of rat hippocampal granule cells. Neuroreport. 7: 682-6. PMID 8730856 DOI: 10.1097/00001756-199601310-00071  0.64
1996 Goodman LJ, Valverde J, Lim F, Geschwind MD, Federoff HJ, Geller AI, Hefti F. Regulated release and polarized localization of brain-derived neurotrophic factor in hippocampal neurons. Molecular and Cellular Neurosciences. 7: 222-38. PMID 8726105 DOI: 10.1006/mcne.1996.0017  0.64
1996 Treanor JJ, Goodman L, de Sauvage F, Stone DM, Poulsen KT, Beck CD, Gray C, Armanini MP, Pollock RA, Hefti F, Phillips HS, Goddard A, Moore MW, Buj-Bello A, Davies AM, et al. Characterization of a multicomponent receptor for GDNF. Nature. 382: 80-3. PMID 8657309 DOI: 10.1038/382080a0  0.64
1996 Knusel B, Kaplan DR, Hefti F. Intraparenchymal NGF injections in adult and aged rats induce long-lasting Trk tyrosine phosphorylation. Experimental Neurology. 139: 121-30. PMID 8635559 DOI: 10.1006/exnr.1996.0087  0.64
1996 Venero JL, Hefti F, Knusel B. Trophic effect of exogenous nerve growth factor on rat striatal cholinergic neurons: comparison between intraparenchymal and intraventricular administration. Molecular Pharmacology. 49: 303-10. PMID 8632763  0.64
1996 Qiao X, Hefti F, Knusel B, Noebels JL. Selective failure of brain-derived neurotrophic factor mRNA expression in the cerebellum of stargazer, a mutant mouse with ataxia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 640-8. PMID 8551348  0.64
1996 Gao H, Qiao X, Hefti F, Knusel B, Hollyfield JG. Elevated BDNF mRNA expression in retinal ganglion cells following optic nerve injury Investigative Ophthalmology and Visual Science. 37: S493.  0.64
1996 Hefti F. Neurotrophic factor prevention of cortical and hippocampal neurone atrophy Alzheimer's Research. 2: 15-17.  0.64
1995 Dugich-Djordjevic MM, Peterson C, Isono F, Ohsawa F, Widmer HR, Denton TL, Bennett GL, Hefti F. Immunohistochemical visualization of brain-derived neurotrophic factor in the rat brain. The European Journal of Neuroscience. 7: 1831-9. PMID 8528456 DOI: 10.1111/j.1460-9568.1995.tb00703.x  0.64
1995 Levi AD, Bunge RP, Lofgren JA, Meima L, Hefti F, Nikolics K, Sliwkowski MX. The influence of heregulins on human Schwann cell proliferation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 1329-40. PMID 7869101  0.64
1995 Beck KD, Valverde J, Alexi T, Poulsen K, Moffat B, Vandlen RA, Rosenthal A, Hefti F. Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain. Nature. 373: 339-41. PMID 7830767 DOI: 10.1038/373339a0  0.64
1995 Venero JL, Hefti F, Beck KD. Retrograde transport of nerve growth factor from hippocampus and amygdala to trkA messenger RNA expressing neurons in paraventricular and reuniens nuclei of the thalamus. Neuroscience. 64: 855-60. PMID 7753386 DOI: 10.1016/0306-4522(94)00533-B  0.64
1995 Winslow JW, Moran P, Valverde J, Shih A, Yuan JQ, Wong SC, Tsai SP, Goddard A, Henzel WJ, Hefti F. Cloning of AL-1, a ligand for an Eph-related tyrosine kinase receptor involved in axon bundle formation. Neuron. 14: 973-81. PMID 7748564  0.64
1995 Beck KD, Powell-Braxton L, Widmer HR, Valverde J, Hefti F. Igf1 gene disruption results in reduced brain size, CNS hypomyelination, and loss of hippocampal granule and striatal parvalbumin-containing neurons. Neuron. 14: 717-30. PMID 7718235 DOI: 10.1016/0896-6273(95)90216-3  0.64
1995 Dugich-Djordjevic MM, Ohsawa F, Okazaki T, Mori N, Day JR, Beck KD, Hefti F. Differential regulation of catalytic and non-catalytic trkB messenger RNAs in the rat hippocampus following seizures induced by systemic administration of kainate. Neuroscience. 66: 861-77. PMID 7651614 DOI: 10.1016/0306-4522(94)00631-E  0.64
1995 Gao WQ, Dybdal N, Shinsky N, Murnane A, Schmelzer C, Siegel M, Keller G, Hefti F, Phillips HS, Winslow JW. Neurotrophin-3 reverses experimental cisplatin-induced peripheral sensory neuropathy. Annals of Neurology. 38: 30-7. PMID 7611721 DOI: 10.1002/ana.410380108  0.64
1995 Beck KD, Hefti F. Induction of non-catalytic TrkB neurotrophin receptors during lesion-induced synaptic rearrangement in the adult rat hippocampus. Progress in Brain Research. 105: 197-210. PMID 7568878  0.64
1995 Treanor JJ, Schmelzer C, Knusel B, Winslow JW, Shelton DL, Hefti F, Nikolics K, Burton LE. Heterodimeric neurotrophins induce phosphorylation of Trk receptors and promote neuronal differentiation in PC12 cells. The Journal of Biological Chemistry. 270: 23104-10. PMID 7559453 DOI: 10.1074/jbc.270.39.23104  0.64
1994 Knüsel B, Rabin SJ, Hefti F, Kaplan DR. Regulated neurotrophin receptor responsiveness during neuronal migrationand early differentiation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 1542-54. PMID 8126554  0.64
1994 Lapchak PA, Araujo DM, Hefti F. Effects of chronic nerve growth factor treatment on hippocampal [3H]cytisine/nicotinic binding sites and presynaptic nicotinic receptor function following fimbrial transections. Neuroscience. 60: 293-8. PMID 8072684 DOI: 10.1016/0306-4522(94)90243-7  0.64
1994 Venero JL, Knüsel B, Beck KD, Hefti F. Expression of neurotrophin and trk receptor genes in adult rats with fimbria transections: effect of intraventricular nerve growth factor and brain-derived neurotrophic factor administration. Neuroscience. 59: 797-815. PMID 8058122 DOI: 10.1016/0306-4522(94)90285-2  0.64
1994 Venero JL, Beck KD, Hefti F. 6-Hydroxydopamine lesions reduce BDNF mRNA levels in adult rat brain substantia nigra. Neuroreport. 5: 429-32. PMID 8003668  0.64
1994 Venero JL, Beck KD, Hefti F. Intrastriatal infusion of nerve growth factor after quinolinic acid prevents reduction of cellular expression of choline acetyltransferase messenger RNA and trkA messenger RNA, but not glutamate decarboxylase messenger RNA. Neuroscience. 61: 257-68. PMID 7969907 DOI: 10.1016/0306-4522(94)90229-1  0.64
1994 Widmer HR, Hefti F. Stimulation of GABAergic neuron differentiation by NT-4/5 in cultures of rat cerebral cortex. Brain Research. Developmental Brain Research. 80: 279-84. PMID 7955354 DOI: 10.1016/0165-3806(94)90114-7  0.64
1994 Widmer HR, Hefti F. Neurotrophin-4/5 promotes survival and differentiation of rat striatal neurons developing in culture. The European Journal of Neuroscience. 6: 1669-79. PMID 7874306 DOI: 10.1111/j.1460-9568.1994.tb00559.x  0.64
1994 Beck KD, Hefti F, Widmer HR. Deafferentation removes calretinin immunopositive terminals, but does not induce degeneration of calbindin D-28k and parvalbumin expressing neurons in the hippocampus of adult rats. Journal of Neuroscience Research. 39: 298-304. PMID 7869422 DOI: 10.1002/jnr.490390307  0.64
1994 Hefti F. Neurotrophic factor therapy for nervous system degenerative diseases. Journal of Neurobiology. 25: 1418-35. PMID 7852995 DOI: 10.1002/neu.480251109  0.64
1994 Hefti F. Development of effective therapy for Alzheimer's disease based on neurotrophic factors. Neurobiology of Aging. 15: S193-4. PMID 7700452 DOI: 10.1016/0197-4580(94)90204-6  0.64
1994 Isono F, Widmer HR, Hefti F, Knüsel B. Epidermal growth factor induces PC12 cell differentiation in the presence of the protein kinase inhibitor K-252a. Journal of Neurochemistry. 63: 1235-45. PMID 7523586  0.64
1993 Efange SM, Michelson RH, Knusel B, Hefti F, Boudreau RJ, Thomas JR, Tennison JR. Synthesis and biological evaluation of radioiodinated N-2-(4-piperidyl)ethyl benzamides. Nuclear Medicine and Biology. 20: 527-38. PMID 8504292 DOI: 10.1016/0969-8051(93)90083-7  0.64
1993 Hefti F, Lapchak PA. Pharmacology of nerve growth factor in the brain. Advances in Pharmacology (San Diego, Calif.). 24: 239-73. PMID 8504065  0.64
1993 Widmer HR, Alexi T, Valverde J, Knüsel B, Hefti F. TGF alpha stimulation of phosphatidylinositol hydrolysis in mesencephalic cultures requires neuron-glia interactions. Neuroreport. 4: 407-10. PMID 8499599  0.64
1993 Widmer HR, Knüsel B, Hefti F. BDNF protection of basal forebrain cholinergic neurons after axotomy: complete protection of p75NGFR-positive cells. Neuroreport. 4: 363-6. PMID 8499589  0.64
1993 Lapchak PA, Araujo DM, Hefti F. Systemic interleukin-1 beta decreases brain-derived neurotrophic factor messenger RNA expression in the rat hippocampal formation. Neuroscience. 53: 297-301. PMID 8492907 DOI: 10.1016/0306-4522(93)90196-M  0.64
1993 Widmer HR, Kaplan DR, Rabin SJ, Beck KD, Hefti F, Knüsel B. Rapid phosphorylation of phospholipase C gamma 1 by brain-derived neurotrophic factor and neurotrophin-3 in cultures of embryonic rat cortical neurons. Journal of Neurochemistry. 60: 2111-23. PMID 8492120  0.64
1993 Lapchak PA, Araujo DM, Beck KD, Finch CE, Johnson SA, Hefti F. BDNF and trkB mRNA expression in the hippocampal formation of aging rats. Neurobiology of Aging. 14: 121-6. PMID 8487914 DOI: 10.1016/0197-4580(93)90087-R  0.64
1993 Lapchak PA, Araujo DM, Hefti F. BDNF and trkB mRNA expression in the rat hippocampus following entorhinal cortex lesions. Neuroreport. 4: 191-4. PMID 8453058  0.64
1993 Lapchak PA, Araujo DM, Hefti F. Cholinergic regulation of hippocampal brain-derived neurotrophic factor mRNA expression: evidence from lesion and chronic cholinergic drug treatment studies. Neuroscience. 52: 575-85. PMID 8450959 DOI: 10.1016/0306-4522(93)90407-7  0.64
1993 Beck KD, Lamballe F, Klein R, Barbacid M, Schauwecker PE, McNeill TH, Finch CE, Hefti F, Day JR. Induction of noncatalytic TrkB neurotrophin receptors during axonal sprouting in the adult hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 13: 4001-14. PMID 8396171  0.64
1993 Lapchak PA, Araujo DM, Hefti F. Regulation of hippocampal muscarinic receptor function by chronic nerve growth factor treatment in adult rats with fimbrial transections. Neuroscience. 53: 379-94. PMID 8388084 DOI: 10.1016/0306-4522(93)90202-Q  0.64
1993 Venero JL, Hefti F. TrkA NGF receptor expression by non-cholinergic thalamic neurons. Neuroreport. 4: 959-62. PMID 8369489  0.64
1993 Araujo DM, Lapchak PA, Hefti F. Effects of chronic basic fibroblast growth factor administration to rats with partial fimbrial transections on presynaptic cholinergic parameters and muscarinic receptors in the hippocampus: comparison with nerve growth factor. Journal of Neurochemistry. 61: 899-910. PMID 8360689  0.64
1993 Widmer HR, Ohsawa F, Knüsel B, Hefti F. Down-regulation of phosphatidylinositol response to BDNF and NT-3 in cultures of cortical neurons. Brain Research. 614: 325-34. PMID 8348325 DOI: 10.1016/0006-8993(93)91051-S  0.64
1993 Lapchak PA, Araujo DM, Carswell S, Hefti F. Distribution of [125I]nerve growth factor in the rat brain following a single intraventricular injection: correlation with the topographical distribution of trkA messenger RNA-expressing cells. Neuroscience. 54: 445-60. PMID 8336831 DOI: 10.1016/0306-4522(93)90265-H  0.64
1993 Hefti F, Knusel B, Lapchak PA. Protective effects of nerve growth factor and brain-derived neurotrophic factor on basal forebrain cholinergic neurons in adult rats with partial fimbrial transections. Progress in Brain Research. 98: 257-63. PMID 8248515  0.64
1993 Dugich-Djordjevic MM, Ohsawa F, Hefti F. Transient elevation in catalytic trkB mRNA during postnatal development of the rat brain. Neuroreport. 4: 1091-4. PMID 8219033  0.64
1993 Lapchak PA, Araujo DM, Pasinetti G, Hefti F. Differential alterations of cortical cholinergic and neurotensin markers following ibotenic acid lesions of the nucleus basalis magnocellularis. Brain Research. 613: 239-46. PMID 8186970 DOI: 10.1016/0006-8993(93)90904-2  0.64
1993 Lapchak PA, Beck KD, Araujo DM, Irwin I, Langston JW, Hefti F. Chronic intranigral administration of brain-derived neurotrophic factor produces striatal dopaminergic hypofunction in unlesioned adult rats and fails to attenuate the decline of striatal dopaminergic function following medial forebrain bundle transection. Neuroscience. 53: 639-50. PMID 8098137 DOI: 10.1016/0306-4522(93)90612-J  0.64
1993 Beck KD, Knüsel B, Hefti F. The nature of the trophic action of brain-derived neurotrophic factor, des(1-3)-insulin-like growth factor-1, and basic fibroblast growth factor on mesencephalic dopaminergic neurons developing in culture. Neuroscience. 52: 855-66. PMID 8095710 DOI: 10.1016/0306-4522(93)90534-M  0.64
1993 Ohsawa F, Widmer HR, Knusel B, Denton TL, Hefti F. Response of embryonic rat hippocampal neurons in culture to neurotrophin-3, brain-derived neurotrophic factor and basic fibroblast growth factor. Neuroscience. 57: 67-77. PMID 8074745 DOI: 10.1016/0306-4522(93)90112-S  0.64
1993 Pallage V, Knusel B, Hefti F, Will B. Functional consequences of a single nerve growth factor administration following septal damage in rats. The European Journal of Neuroscience. 5: 669-79. PMID 7903189  0.64
1993 Alexi T, Hefti F. Trophic actions of transforming growth factor alpha on mesencephalic dopaminergic neurons developing in culture. Neuroscience. 55: 903-18. PMID 7901801 DOI: 10.1016/0306-4522(93)90307-2  0.64
1993 Knüsel B, Hefti F. Multiple and interactive responses of central neurons to neurotrophic factors Seminars in Neuroscience. 5: 259-267. DOI: 10.1016/S1044-5765(05)80031-4  0.64
1993 Beck KD, Hefti F. Neurotrophic factor therapy of Alzheimer's disease Clinical Neuroscience. 1: 219-224.  0.64
1992 Lapchak PA, Araujo DM, Hefti F. Neurotrophins in the central nervous system. Reviews in the Neurosciences. 3: 1-10. PMID 21561275 DOI: 10.1515/REVNEURO.1992.3.1.1  0.64
1992 Dugich-Djordjevic MM, Tocco G, Lapchak PA, Pasinetti GM, Najm I, Baudry M, Hefti F. Regionally specific and rapid increases in brain-derived neurotrophic factor messenger RNA in the adult rat brain following seizures induced by systemic administration of kainic acid. Neuroscience. 47: 303-15. PMID 1641125 DOI: 10.1016/0306-4522(92)90246-X  0.64
1992 Knüsel B, Kaplan DR, Winslow JW, Rosenthal A, Burton LE, Beck KD, Rabin S, Nikolics K, Hefti F. K-252b selectively potentiates cellular actions and trk tyrosine phosphorylation mediated by neurotrophin-3. Journal of Neurochemistry. 59: 715-22. PMID 1629741  0.64
1992 Dugich-Djordjevic MM, Tocco G, Willoughby DA, Najm I, Pasinetti G, Thompson RF, Baudry M, Lapchak PA, Hefti F. BDNF mRNA expression in the developing rat brain following kainic acid-induced seizure activity. Neuron. 8: 1127-38. PMID 1610567 DOI: 10.1016/0896-6273(92)90133-X  0.64
1992 Knüsel B, Beck KD, Winslow JW, Rosenthal A, Burton LE, Widmer HR, Nikolics K, Hefti F. Brain-derived neurotrophic factor administration protects basal forebrain cholinergic but not nigral dopaminergic neurons from degenerative changes after axotomy in the adult rat brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 12: 4391-402. PMID 1432101  0.64
1992 Widmer HR, Knüsel B, Hefti F. Stimulation of phosphatidylinositol hydrolysis by brain-derived neurotrophic factor and neurotrophin-3 in rat cerebral cortical neurons developing in culture. Journal of Neurochemistry. 59: 2113-24. PMID 1431896  0.64
1992 Knüsel B, Hefti F. K-252 compounds: modulators of neurotrophin signal transduction. Journal of Neurochemistry. 59: 1987-96. PMID 1431889  0.64
1992 Knüsel B, Rabin S, Widmer HR, Hefti F, Kaplan DR. Neurotrophin-induced trk receptor phosphorylation and cholinergic neuron response in primary cultures of embryonic rat brain neurons. Neuroreport. 3: 885-8. PMID 1421094  0.64
1992 Lorenzi MV, Knusel B, Hefti F, Strauss WL. Nerve growth factor regulation of choline acetyltransferase gene expression in rat embryo basal forebrain cultures. Neuroscience Letters. 140: 185-8. PMID 1380145 DOI: 10.1016/0304-3940(92)90098-R  0.64
1992 Hefti F, Araujo DM, Beck KD, Day JR, Finch CE, Knusel B, Lapchak PA, McNeill TH. Neurotrophins and neurotrophin receptors in adult brain plasticity Journal of Neural Transplantation and Plasticity. 3: 265-266.  0.64
1991 Koliatsos VE, Applegate MD, Knüsel B, Junard EO, Burton LE, Mobley WC, Hefti FF, Price DL. Recombinant human nerve growth factor prevents retrograde degeneration of axotomized basal forebrain cholinergic neurons in the rat. Experimental Neurology. 112: 161-73. PMID 2037030 DOI: 10.1016/0014-4886(91)90066-L  0.64
1991 Hefti F, Denton TL, Beck KD, Michel PP. No relevance to Parkinson's. Nature. 352: 573. PMID 1830925 DOI: 10.1038/352573b0  0.64
1991 Koliatsos VE, Clatterbuck RE, Nauta HJ, Knüsel B, Burton LE, Hefti FF, Mobley WC, Price DL. Human nerve growth factor prevents degeneration of basal forebrain cholinergic neurons in primates. Annals of Neurology. 30: 831-40. PMID 1789695 DOI: 10.1002/ana.410300613  0.64
1991 Hefti F, Junard EO, Knüsel B, Strauss WL, Strang PF, Przybylski A, Vaughan G, Fox SW. Promotion of neuronal survival in vitro by thermal proteins and poly(dicarboxylic)amino acids. Brain Research. 541: 273-83. PMID 1711399 DOI: 10.1016/0006-8993(91)91028-Y  0.64
1991 Beck KD, Knusel B, Pasinetti G, Michel PP, Zawadzka H, Goldstein M, Hefti F. Tyrosine hydroxylase mRNA expression by dopaminergic neurons in culture: effect of 1-methyl-4-phenylpyridinium treatment. Journal of Neurochemistry. 57: 527-32. PMID 1677030  0.64
1990 Rabey JM, Hefti F. Neuromelanin synthesis in rat and human substantia nigra. Journal of Neural Transmission. Parkinson's Disease and Dementia Section. 2: 1-14. PMID 2357268 DOI: 10.1007/BF02251241  0.64
1990 Knüsel B, Burton LE, Longo FM, Mobley WC, Koliatsos VE, Price DL, Hefti F. Trophic actions of recombinant human nerve growth factor on cultured rat embryonic CNS cells. Experimental Neurology. 110: 274-83. PMID 2249737 DOI: 10.1016/0014-4886(90)90039-U  0.64
1990 Michel PP, Dandapani BK, Knusel B, Sanchez-Ramos J, Hefti F. Toxicity of 1-methyl-4-phenylpyridinium for rat dopaminergic neurons in culture: selectivity and irreversibility. Journal of Neurochemistry. 54: 1102-9. PMID 1968953  0.64
1989 Michel PP, Dandapani BK, Sanchez-Ramos J, Efange S, Pressman BC, Hefti F. Toxic effects of potential environmental neurotoxins related to 1-methyl-4-phenylpyridinium on cultured rat dopaminergic neurons. The Journal of Pharmacology and Experimental Therapeutics. 248: 842-50. PMID 2783974  0.64
1989 Factor SA, Weiner WJ, Hefti F. Acetaminophen metabolism by cytochrome P450 monooxygenases in Parkinson's disease. Annals of Neurology. 26: 286-8. PMID 2774516 DOI: 10.1002/ana.410260219  0.64
1989 Phelps CH, Gage FH, Growdon JH, Hefti F, Harbaugh R, Johnston MV, Khachaturian ZS, Mobley WC, Price DL, Raskind M. Potential use of nerve growth factor to treat Alzheimer's disease. Neurobiology of Aging. 10: 205-7. PMID 2657468 DOI: 10.1016/0197-4580(89)90032-8  0.64
1988 Sanchez-Ramos JR, Michel P, Weiner WJ, Hefti F. Selective destruction of cultured dopaminergic neurons from fetal rat mesencephalon by 1-methyl-4-phenylpyridinium: cytochemical and morphological evidence. Journal of Neurochemistry. 50: 1934-44. PMID 2897430  0.64
1987 Fox SW, Hefti F, Hartikka J, Junard E, Przybylski AT, Vaughan G. Pharmacological activities in thermal proteins: relationships in molecular evolution. International Journal of Quantum Chemistry. Quantum Biology Symposium : Proceedings of the International Symposium On Quantum Biology and Quantum Pharmacology. International Symposium On Quantum Biology and Quantum Pharmacology. 14: 347-9. PMID 11542106  0.64
1987 Gähwiler BH, Enz A, Hefti F. Nerve growth factor promotes development of the rat septo-hippocampal cholinergic projection in vitro. Neuroscience Letters. 75: 6-10. PMID 3574769 DOI: 10.1016/0304-3940(87)90066-8  0.64
1986 Korsching S, Heumann R, Thoenen H, Hefti F. Cholinergic denervation of the rat hippocampus by fimbrial transection leads to a transient accumulation of nerve growth factor (NGF) without change in mRNANGF content. Neuroscience Letters. 66: 175-80. PMID 3725184 DOI: 10.1016/0304-3940(86)90186-2  0.64
1986 Sanchez-Ramos J, Barrett JN, Goldstein M, Weiner WJ, Hefti F. 1-Methyl-4-phenylpyridinium (MPP+) but not 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) selectively destroys dopaminergic neurons in cultures of dissociated rat mesencephalic neurons. Neuroscience Letters. 72: 215-20. PMID 2880321 DOI: 10.1016/0304-3940(86)90083-2  0.64
1985 Hefti F, Hartikka J, Schlumpf M. Implantation of PC12 cells into the corpus striatum of rats with lesions of the dopaminergic nigrostriatal neurons. Brain Research. 348: 283-8. PMID 4075086  0.44
1985 Melamed E, Hefti F. Altered pharmacokinetics of L-dopa metabolism. Neurology. 35: 939-41. PMID 4000502  1
1985 Gähwiler BH, Hefti F. Striatal acetylcholinesterase-containing interneurons innervate hippocampal tissue in co-cultured slices. Brain Research. 350: 311-4. PMID 3986621 DOI: 10.1016/0165-3806(85)90276-7  0.64
1985 Hefti F, Enz A, Melamed E. Partial lesions of the nigrostriatal pathway in the rat. Acceleration of transmitter synthesis and release of surviving dopaminergic neurones by drugs. Neuropharmacology. 24: 19-23. PMID 2858830  1
1984 Melamed E, Hefti F. Mechanism of action of short- and long-term L-DOPA treatment in parkinsonism: role of the surviving nigrostriatal dopaminergic neurons. Advances in Neurology. 40: 149-57. PMID 6695591  1
1984 Gähwiler BH, Hefti F. Guidance of acetylcholinesterase-containing fibres by target tissue in co-cultured brain slices. Neuroscience. 13: 681-9. PMID 6527774 DOI: 10.1016/0306-4522(84)90088-5  0.64
1984 Melamed E, Hefti F, Bitton V, Globus M. Suppression of L-dopa-induced circling in rats with nigral lesions by blockade of central dopa-decarboxylase: implications for mechanism of action of L-dopa in parkinsonism. Neurology. 34: 1566-70. PMID 6504328  1
1984 Enz A, Hefti F, Frick W. Acute administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) reduces dopamine and serotonin but accelerates norepinephrine metabolism in the rat brain. Effect of chronic pretreatment with MPTP. European Journal of Pharmacology. 101: 37-44. PMID 6086364  0.6
1983 Hefti F, Felix D. Chronoamperometry in vivo: does it interfere with spontaneous neuronal activity in the brain? Journal of Neuroscience Methods. 7: 151-6. PMID 6300566  0.44
1983 Gnahn H, Hefti F, Heumann R, Schwab ME, Thoenen H. NGF-mediated increase of choline acetyltransferase (ChAT) in the neonatal rat forebrain: evidence for a physiological role of NGF in the brain? Brain Research. 285: 45-52. PMID 6136314 DOI: 10.1016/0165-3806(83)90107-4  0.64
1983 Harper GP, Barde YA, Edgar D, Ganten D, Hefti F, Heumann R, Naujoks KW, Rohrer H, Turner JE, Thoenen H. Biological and immunological properties of the nerve growth factor from bovine seminal plasma: comparison with the properties of mouse nerve growth factor. Neuroscience. 8: 375-87. PMID 6133237 DOI: 10.1016/0306-4522(83)90073-8  0.64
1982 Lichtensteiger W, Hefti F, Felix D, Huwyler T, Melamed E, Schlumpf M. Stimulation of nigrostriatal dopamine neurones by nicotine. Neuropharmacology. 21: 963-8. PMID 7145035  1
1982 Melamed E, Hefti F, Bird ED. Huntington chorea is not associated with hyperactivity of nigrostriatal dopaminergic neurons: studies in postmortem tissues and in rats with kainic acid lesions. Neurology. 32: 640-4. PMID 6211637  1
1982 Growdon JH, Melamed E, Logue M, Hefti F, Wurtman RJ. Effects of oral L-tyrosine administration on CSF tyrosine and homovanillic acid levels in patients with Parkinson's disease. Life Sciences. 30: 827-32. PMID 6175872  1
1982 Hefti F, Gnahn H, Schwab ME, Thoenen H. Induction of tyrosine hydroxylase by nerve growth factor and by elevated K+ concentrations in cultures of dissociated sympathetic neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 2: 1554-66. PMID 6128379  0.64
1982 Melamed E, Hefti F, Wurtman RJ. Compensatory mechanisms in the nigrostriatal dopaminergic system in Parkinson's disease: studies in an animal model. Israel Journal of Medical Sciences. 18: 159-63. PMID 6121770  1
1981 Hefti F, Melamed E. Dopamine release in rat striatum after administration of L-dope as studied with in vivo electrochemistry. Brain Research. 225: 333-46. PMID 7306794  1
1981 Hefti F, Melamed E, Wurtman RJ. The site of dopamine formation in rat striatum after L-dopa administration. The Journal of Pharmacology and Experimental Therapeutics. 217: 189-97. PMID 7205652  1
1981 Melamed E, Hefti F, Pettibone DJ, Liebman J, Wurtman RJ. Aromatic L-amino acid decarboxylase in rat corpus striatum: implications for action of L-dopa in parkinsonism. Neurology. 31: 651-5. PMID 7195482  0.64
1980 Morre MC, Hefti F, Wurtman RJ. Regional tyrosine levels in rat brain after tyrosine administration. Journal of Neural Transmission. 49: 45-50. PMID 7441238  1
1980 Melamed E, Hefti F, Wurtman RJ. Decarboxylation of exogenous L-DOPA in rat striatum after lesions of the dopaminergic nigrostriatal neurons: the role of striatal capillaries. Brain Research. 198: 244-8. PMID 7407592  1
1980 Melamed E, Hefti F, Wurtman RJ. Diminished decarboxylation of L-DOPA in rat striatum after intrastriatal injections of kainic acid. Neuropharmacology. 19: 409-11. PMID 7383284  1
1980 Melamed E, Hefti F, Wurtman RJ. L-3,4-Dihydroxyphenylalanine and L-5-hydroxytryptophan decarboxylase activities in rat striatum: effect of selective destruction of dopaminergic or serotoninergic input. Journal of Neurochemistry. 34: 1753-6. PMID 7381499  1
1980 Hefti F, Melamed E, Sahakian BJ, Wurtman RJ. Circling behavior in rats with partial, unilateral nigro-striatal lesions: effect of amphetamine, apomorphine, and DOPA. Pharmacology, Biochemistry, and Behavior. 12: 185-8. PMID 7189592  1
1980 Hefti F, Melamed E, Wurtman RJ. The decarboxylation of DOPA in the parkinsonian brain: in vivo studies on an animal model. Journal of Neural Transmission. Supplementum. 95-101. PMID 6776238  1
1980 Melamed E, Hefti F, Wurtman RJ. Nonaminergic striatal neurons convert exogenous L-dopa to dopamine in parkinsonism. Annals of Neurology. 8: 558-63. PMID 6260009 DOI: 10.1002/ana.410080603  1
1980 Melamed E, Hefti F, Wurtman RJ. Tyrosine administration increases striatal dopamine release in rats with partial nigrostriatal lesions. Proceedings of the National Academy of Sciences of the United States of America. 77: 4305-9. PMID 6254020  1
1980 Wurtman RJ, Hefti F, Melamed E. Precursor control of neurotransmitter synthesis. Pharmacological Reviews. 32: 315-35. PMID 6115400  1
1980 Hefti F, Melamed E, Wurtman RJ. Partial lesions of the dopaminergic nigrostriatal system in rat brain: biochemical characterization. Brain Research. 195: 123-37. PMID 6105003  1
1980 Melamed E, Hefti F, Liebman J, Schlosberg AJ, Wurtman RJ. Serotonergic neurones are not involved in action of L-dopa in Parkinson's disease. Nature. 283: 772-4. PMID 6101905  1
1979 Lichtensteiger W, Felix D, Hefti F. Spike activity and histofluorescence correlated in the giant dopamine neurone of Planorbis corneus. Brain Research. 170: 231-45. PMID 466409  0.44
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