Roger M. Nitsch, MD - Publications

Affiliations: 
Psychiatry Universität Zürich, Zürich, ZH, Switzerland 
Area:
Alzheimer’s disease, genetics
Website:
http://www.dpr.uzh.ch/aboutus/People/directors/nitsch.html

190 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Sevigny J, Chiao P, Bussière T, Weinreb PH, Williams L, Maier M, Dunstan R, Salloway S, Chen T, Ling Y, O'Gorman J, Qian F, Arastu M, Li M, Chollate S, ... ... Nitsch RM, et al. The antibody aducanumab reduces Aβ plaques in Alzheimer's disease. Nature. 537: 50-6. PMID 27582220 DOI: 10.1038/nature19323  1
2015 Jelcic I, Combaluzier B, Jelcic I, Faigle W, Senn L, Reinhart BJ, Ströh L, Nitsch RM, Stehle T, Sospedra M, Grimm J, Martin R. Broadly neutralizing human monoclonal JC polyomavirus VP1-specific antibodies as candidate therapeutics for progressive multifocal leukoencephalopathy. Science Translational Medicine. 7: 306ra150. PMID 26400911 DOI: 10.1126/scitranslmed.aac8691  1
2015 Hyman BT, Growdon JH, Albers MW, Buckner RL, Chhatwal J, Gomez-Isla MT, Haass C, Hudry E, Jack CR, Johnson KA, Khachaturian ZS, Kim DY, Martin JB, Nitsch RM, Rosen BR, et al. Massachusetts Alzheimer's Disease Research Center: Progress and challenges. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 26297855 DOI: 10.1016/j.jalz.2015.06.1887  1
2015 Spescha RD, Klohs J, Semerano A, Giacalone G, Derungs RS, Reiner MF, Rodriguez Gutierrez D, Mendez-Carmona N, Glanzmann M, Savarese G, Kränkel N, Akhmedov A, Keller S, Mocharla P, Kaufmann MR, ... ... Nitsch RM, et al. Post-ischaemic silencing of p66Shc reduces ischaemia/reperfusion brain injury and its expression correlates to clinical outcome in stroke. European Heart Journal. 36: 1590-600. PMID 25904764 DOI: 10.1093/eurheartj/ehv140  1
2015 Welt T, Kulic L, Hoey SE, McAfoose J, Späni C, Chadha AS, Fisher A, Nitsch RM. Acute Effects of Muscarinic M1 Receptor Modulation on AβPP Metabolism and Amyloid-β Levels in vivo: A Microdialysis Study. Journal of Alzheimer's Disease : Jad. PMID 25881909 DOI: 10.3233/JAD-150152  1
2015 Gietl AF, Warnock G, Riese F, Kälin AM, Saake A, Gruber E, Leh SE, Unschuld PG, Kuhn FP, Burger C, Mu L, Seifert B, Nitsch RM, Schibli R, Ametamey SM, et al. Regional cerebral blood flow estimated by early PiB uptake is reduced in mild cognitive impairment and associated with age in an amyloid-dependent manner. Neurobiology of Aging. 36: 1619-28. PMID 25702957 DOI: 10.1016/j.neurobiolaging.2014.12.036  1
2014 Grandjean J, Schroeter A, He P, Tanadini M, Keist R, Krstic D, Konietzko U, Klohs J, Nitsch RM, Rudin M. Early alterations in functional connectivity and white matter structure in a transgenic mouse model of cerebral amyloidosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 13780-9. PMID 25297104 DOI: 10.1523/JNEUROSCI.4762-13.2014  1
2014 Schreiner SJ, Liu X, Gietl AF, Wyss M, Steininger SC, Gruber E, Treyer V, Meier IB, Kälin AM, Leh SE, Buck A, Nitsch RM, Pruessmann KP, Hock C, Unschuld PG. Regional Fluid-Attenuated Inversion Recovery (FLAIR) at 7 Tesla correlates with amyloid beta in hippocampus and brainstem of cognitively normal elderly subjects. Frontiers in Aging Neuroscience. 6: 240. PMID 25249977 DOI: 10.3389/fnagi.2014.00240  1
2014 Keskitalo S, Farkas M, Hanenberg M, Szodorai A, Kulic L, Semmler A, Weller M, Nitsch RM, Linnebank M. Reciprocal modulation of Aβ42 aggregation by copper and homocysteine. Frontiers in Aging Neuroscience. 6: 237. PMID 25249976 DOI: 10.3389/fnagi.2014.00237  1
2014 Hanenberg M, McAfoose J, Kulic L, Welt T, Wirth F, Parizek P, Strobel L, Cattepoel S, Späni C, Derungs R, Maier M, Plückthun A, Nitsch RM. Amyloid-β peptide-specific DARPins as a novel class of potential therapeutics for Alzheimer disease. The Journal of Biological Chemistry. 289: 27080-9. PMID 25118284 DOI: 10.1074/jbc.M114.564013  1
2014 Kälin AM, Pflüger M, Gietl AF, Riese F, Jäncke L, Nitsch RM, Hock C. Intraindividual variability across cognitive tasks as a potential marker for prodromal Alzheimer's disease. Frontiers in Aging Neuroscience. 6: 147. PMID 25071556 DOI: 10.3389/fnagi.2014.00147  1
2014 Domingues SC, Konietzko U, Henriques AG, Rebelo S, Fardilha M, Nishitani H, Nitsch RM, da Cruz E Silva EF, da Cruz E Silva OA. RanBP9 modulates AICD localization and transcriptional activity via direct interaction with Tip60. Journal of Alzheimer's Disease : Jad. 42: 1415-33. PMID 25024339 DOI: 10.3233/JAD-132495  1
2014 Steininger SC, Liu X, Gietl A, Wyss M, Schreiner S, Gruber E, Treyer V, Kälin A, Leh S, Buck A, Nitsch RM, Prüssmann KP, Hock C, Unschuld PG. Cortical Amyloid Beta in Cognitively Normal Elderly Adults is Associated with Decreased Network Efficiency within the Cerebro-Cerebellar System. Frontiers in Aging Neuroscience. 6: 52. PMID 24672483 DOI: 10.3389/fnagi.2014.00052  1
2013 Laurig M, Liu X, Wyss M, Gietl A, Jellestad L, Nitsch RM, Prüssmann K, Hock C, Unschuld PG. Quantification of subcortical gray-matter vascularization using 7 Tesla time-of-flight angiography. Brain and Behavior. 3: 515-8. PMID 24392272 DOI: 10.1002/brb3.154  1
2013 Riese F, Grinschgl S, Gersbacher MT, Russi N, Hock C, Nitsch RM, Konietzko U. Visualization and quantification of APP intracellular domain-mediated nuclear signaling by bimolecular fluorescence complementation. Plos One. 8: e76094. PMID 24086696 DOI: 10.1371/journal.pone.0076094  1
2013 Gersbacher MT, Goodger ZV, Trutzel A, Bundschuh D, Nitsch RM, Konietzko U. Turnover of amyloid precursor protein family members determines their nuclear signaling capability. Plos One. 8: e69363. PMID 23874953 DOI: 10.1371/journal.pone.0069363  1
2013 Klohs J, Politano IW, Deistung A, Grandjean J, Drewek A, Dominietto M, Keist R, Schweser F, Reichenbach JR, Nitsch RM, Knuesel I, Rudin M. Longitudinal Assessment of Amyloid Pathology in Transgenic ArcAβ Mice Using Multi-Parametric Magnetic Resonance Imaging. Plos One. 8: e66097. PMID 23840405 DOI: 10.1371/journal.pone.0066097  1
2013 Tackenberg C, Grinschgl S, Trutzel A, Santuccione AC, Frey MC, Konietzko U, Grimm J, Brandt R, Nitsch RM. NMDA receptor subunit composition determines beta-amyloid-induced neurodegeneration and synaptic loss. Cell Death & Disease. 4: e608. PMID 23618906 DOI: 10.1038/cddis.2013.129  1
2013 Bengtsson SK, Johansson M, Backstrom T, Nitsch RM, Wang M. Brief but chronic increase in allopregnanolone cause accelerated AD pathology differently in two mouse models. Current Alzheimer Research. 10: 38-47. PMID 23157375  1
2013 Spescha RD, Shi Y, Wegener S, Keller S, Weber B, Wyss MM, Lauinger N, Tabatabai G, Paneni F, Cosentino F, Hock C, Weller M, Nitsch RM, Lüscher TF, Camici GG. Deletion of the ageing gene p66(Shc) reduces early stroke size following ischaemia/reperfusion brain injury. European Heart Journal. 34: 96-103. PMID 23008506 DOI: 10.1093/eurheartj/ehs331  1
2013 Santuccione AC, Merlini M, Shetty A, Tackenberg C, Bali J, Ferretti MT, McAfoose J, Kulic L, Bernreuther C, Welt T, Grimm J, Glatzel M, Rajendran L, Hock C, Nitsch RM. Active vaccination with ankyrin G reduces β-amyloid pathology in APP transgenic mice. Molecular Psychiatry. 18: 358-68. PMID 22688190 DOI: 10.1038/mp.2012.70  1
2012 Kulic L, McAfoose J, Welt T, Tackenberg C, Späni C, Wirth F, Finder V, Konietzko U, Giese M, Eckert A, Noriaki K, Shimizu T, Murakami K, Irie K, Rasool S, ... ... Nitsch RM, et al. Early accumulation of intracellular fibrillar oligomers and late congophilic amyloid angiopathy in mice expressing the Osaka intra-Aβ APP mutation. Translational Psychiatry. 2: e183. PMID 23149447 DOI: 10.1038/tp.2012.109  1
2012 Kohli BM, Pflieger D, Mueller LN, Carbonetti G, Aebersold R, Nitsch RM, Konietzko U. Interactome of the amyloid precursor protein APP in brain reveals a protein network involved in synaptic vesicle turnover and a close association with Synaptotagmin-1. Journal of Proteome Research. 11: 4075-90. PMID 22731840 DOI: 10.1021/pr300123g  1
2012 Biscaro B, Lindvall O, Tesco G, Ekdahl CT, Nitsch RM. Inhibition of microglial activation protects hippocampal neurogenesis and improves cognitive deficits in a transgenic mouse model for Alzheimer's disease. Neuro-Degenerative Diseases. 9: 187-98. PMID 22584394 DOI: 10.1159/000330363  1
2012 Klohs J, Baltes C, Princz-Kranz F, Ratering D, Nitsch RM, Knuesel I, Rudin M. Contrast-enhanced magnetic resonance microangiography reveals remodeling of the cerebral microvasculature in transgenic ArcAβ mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 1705-13. PMID 22302811 DOI: 10.1523/JNEUROSCI.5626-11.2012  1
2011 Klohs J, Deistung A, Schweser F, Grandjean J, Dominietto M, Waschkies C, Nitsch RM, Knuesel I, Reichenbach JR, Rudin M. Detection of cerebral microbleeds with quantitative susceptibility mapping in the ArcAbeta mouse model of cerebral amyloidosis. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 31: 2282-92. PMID 21847134 DOI: 10.1038/jcbfm.2011.118  1
2011 Hermann DM, Keyvani K, van de Nes J, Weimar C, Wiltfang J, Nitsch RM, Szodorai A. Brain-reactive β-amyloid antibodies in primary CNS angiitis with cerebral amyloid angiopathy. Neurology. 77: 503-5. PMID 21775736 DOI: 10.1212/WNL.0b013e318227b250  1
2011 Merlini M, Meyer EP, Ulmann-Schuler A, Nitsch RM. Vascular β-amyloid and early astrocyte alterations impair cerebrovascular function and cerebral metabolism in transgenic arcAβ mice. Acta Neuropathologica. 122: 293-311. PMID 21688176 DOI: 10.1007/s00401-011-0834-y  1
2011 Cattepoel S, Hanenberg M, Kulic L, Nitsch RM. Chronic intranasal treatment with an anti-Aβ(30-42) scFv antibody ameliorates amyloid pathology in a transgenic mouse model of Alzheimer's disease. Plos One. 6: e18296. PMID 21483675 DOI: 10.1371/journal.pone.0018296  1
2011 Attems J, Ittner A, Jellinger K, Nitsch RM, Maj M, Wagner L, Götz J, Heikenwalder M. Reduced secretagogin expression in the hippocampus of P301L tau transgenic mice. Journal of Neural Transmission (Vienna, Austria : 1996). 118: 737-45. PMID 21442354 DOI: 10.1007/s00702-011-0626-5  1
2011 Ovchinnikova OY, Finder VH, Vodopivec I, Nitsch RM, Glockshuber R. The Osaka FAD mutation E22Δ leads to the formation of a previously unknown type of amyloid β fibrils and modulates Aβ neurotoxicity. Journal of Molecular Biology. 408: 780-91. PMID 21402079 DOI: 10.1016/j.jmb.2011.02.049  1
2011 Kulic L, Wollmer MA, Rhein V, Pagani L, Kuehnle K, Cattepoel S, Tracy J, Eckert A, Nitsch RM. Combined expression of tau and the Harlequin mouse mutation leads to increased mitochondrial dysfunction, tau pathology and neurodegeneration. Neurobiology of Aging. 32: 1827-38. PMID 19942317 DOI: 10.1016/j.neurobiolaging.2009.10.014  1
2010 Kocherhans S, Madhusudan A, Doehner J, Breu KS, Nitsch RM, Fritschy JM, Knuesel I. Reduced Reelin expression accelerates amyloid-beta plaque formation and tau pathology in transgenic Alzheimer's disease mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 9228-40. PMID 20610758 DOI: 10.1523/JNEUROSCI.0418-10.2010  1
2010 Princz-Kranz FL, Mueggler T, Knobloch M, Nitsch RM, Rudin M. Vascular response to acetazolamide decreases as a function of age in the arcA beta mouse model of cerebral amyloidosis. Neurobiology of Disease. 40: 284-92. PMID 20600914 DOI: 10.1016/j.nbd.2010.06.002  1
2010 Serrano-Pozo A, William CM, Ferrer I, Uro-Coste E, Delisle MB, Maurage CA, Hock C, Nitsch RM, Masliah E, Growdon JH, Frosch MP, Hyman BT. Beneficial effect of human anti-amyloid-beta active immunization on neurite morphology and tau pathology. Brain : a Journal of Neurology. 133: 1312-27. PMID 20360050 DOI: 10.1093/brain/awq056  1
2010 Finder VH, Vodopivec I, Nitsch RM, Glockshuber R. The recombinant amyloid-beta peptide Abeta1-42 aggregates faster and is more neurotoxic than synthetic Abeta1-42. Journal of Molecular Biology. 396: 9-18. PMID 20026079 DOI: 10.1016/j.jmb.2009.12.016  1
2010 Konietzko U, Goodger ZV, Meyer M, Kohli BM, Bosset J, Lahiri DK, Nitsch RM. Co-localization of the amyloid precursor protein and Notch intracellular domains in nuclear transcription factories. Neurobiology of Aging. 31: 58-73. PMID 18403052 DOI: 10.1016/j.neurobiolaging.2008.03.001  1
2009 Vodopivec I, Galichet A, Knobloch M, Bierhaus A, Heizmann CW, Nitsch RM. RAGE does not affect amyloid pathology in transgenic ArcAbeta mice. Neuro-Degenerative Diseases. 6: 270-80. PMID 20145420 DOI: 10.1159/000261723  1
2009 Biscaro B, Lindvall O, Hock C, Ekdahl CT, Nitsch RM. Abeta immunotherapy protects morphology and survival of adult-born neurons in doubly transgenic APP/PS1 mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 14108-19. PMID 19906959 DOI: 10.1523/JNEUROSCI.2055-09.2009  1
2009 Goodger ZV, Rajendran L, Trutzel A, Kohli BM, Nitsch RM, Konietzko U. Nuclear signaling by the APP intracellular domain occurs predominantly through the amyloidogenic processing pathway. Journal of Cell Science. 122: 3703-14. PMID 19773363 DOI: 10.1242/jcs.048090  1
2009 Kuehnle K, Ledesma MD, Kalvodova L, Smith AE, Crameri A, Skaanes-Brunner F, Thelen KM, Kulic L, Lütjohann D, Heppner FL, Nitsch RM, Mohajeri MH. Age-dependent increase in desmosterol restores DRM formation and membrane-related functions in cholesterol-free DHCR24-/- mice. Neurochemical Research. 34: 1167-82. PMID 19115107 DOI: 10.1007/s11064-008-9893-4  1
2008 Nitsch RM, Hock C. Targeting beta-amyloid pathology in Alzheimer's disease with Abeta immunotherapy. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 5: 415-20. PMID 18625453 DOI: 10.1016/j.nurt.2008.05.013  1
2008 Buchmann A, Mondadori CR, Hänggi J, Aerni A, Vrticka P, Luechinger R, Boesiger P, Hock C, Nitsch RM, de Quervain DJ, Papassotiropoulos A, Henke K. Prion protein M129V polymorphism affects retrieval-related brain activity. Neuropsychologia. 46: 2389-402. PMID 18423780 DOI: 10.1016/j.neuropsychologia.2008.03.002  1
2008 Berson A, Knobloch M, Hanan M, Diamant S, Sharoni M, Schuppli D, Geyer BC, Ravid R, Mor TS, Nitsch RM, Soreq H. Changes in readthrough acetylcholinesterase expression modulate amyloid-beta pathology. Brain : a Journal of Neurology. 131: 109-19. PMID 18056160 DOI: 10.1093/brain/awm276  1
2008 Kuehnle K, Crameri A, Kälin RE, Luciani P, Benvenuti S, Peri A, Ratti F, Rodolfo M, Kulic L, Heppner FL, Nitsch RM, Mohajeri MH. Prosurvival effect of DHCR24/Seladin-1 in acute and chronic responses to oxidative stress. Molecular and Cellular Biology. 28: 539-50. PMID 17984220 DOI: 10.1128/MCB.00584-07  1
2007 Knobloch M, Farinelli M, Konietzko U, Nitsch RM, Mansuy IM. Abeta oligomer-mediated long-term potentiation impairment involves protein phosphatase 1-dependent mechanisms. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 7648-53. PMID 17634359 DOI: 10.1523/JNEUROSCI.0395-07.2007  1
2007 De Ferrari GV, Papassotiropoulos A, Biechele T, Wavrant De-Vrieze F, Avila ME, Major MB, Myers A, Sáez K, Henríquez JP, Zhao A, Wollmer MA, Nitsch RM, Hock C, Morris CM, Hardy J, et al. Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 104: 9434-9. PMID 17517621 DOI: 10.1073/pnas.0603523104  1
2007 Wollmer MA, Sleegers K, Ingelsson M, Zekanowski C, Brouwers N, Maruszak A, Brunner F, Huynh KD, Kilander L, Brundin RM, Hedlund M, Giedraitis V, Glaser A, Engelborghs S, De Deyn PP, ... ... Nitsch RM, et al. Association study of cholesterol-related genes in Alzheimer's disease. Neurogenetics. 8: 179-88. PMID 17387528 DOI: 10.1007/s10048-007-0087-z  1
2007 Mondadori CR, de Quervain DJ, Buchmann A, Mustovic H, Wollmer MA, Schmidt CF, Boesiger P, Hock C, Nitsch RM, Papassotiropoulos A, Henke K. Better memory and neural efficiency in young apolipoprotein E epsilon4 carriers. Cerebral Cortex (New York, N.Y. : 1991). 17: 1934-47. PMID 17077159 DOI: 10.1093/cercor/bhl103  1
2007 Knobloch M, Konietzko U, Krebs DC, Nitsch RM. Intracellular Abeta and cognitive deficits precede beta-amyloid deposition in transgenic arcAbeta mice. Neurobiology of Aging. 28: 1297-306. PMID 16876915 DOI: 10.1016/j.neurobiolaging.2006.06.019  1
2007 Herrling P, Hock C, Nitsch RM. Neurodegenerative Diseases: Preface Neurodegenerative Diseases. 4: 5. DOI: 10.1159/000100891  1
2006 Wollmer MA, Nitsch RM, Hock C, Papassotiropoulos A. Genetic association study on colony-stimulating factor 1 in Alzheimer's disease. Neuro-Degenerative Diseases. 3: 334-7. PMID 17192722 DOI: 10.1159/000097302  1
2006 Mondadori CR, Buchmann A, Mustovic H, Schmidt CF, Boesiger P, Nitsch RM, Hock C, Streffer J, Henke K. Enhanced brain activity may precede the diagnosis of Alzheimer's disease by 30 years. Brain : a Journal of Neurology. 129: 2908-22. PMID 17012294 DOI: 10.1093/brain/awl266  1
2006 Poirier R, Wolfer DP, Welzl H, Tracy J, Galsworthy MJ, Nitsch RM, Mohajeri MH. Neuronal neprilysin overexpression is associated with attenuation of Abeta-related spatial memory deficit. Neurobiology of Disease. 24: 475-83. PMID 17008108 DOI: 10.1016/j.nbd.2006.08.003  1
2006 Madani R, Poirier R, Wolfer DP, Welzl H, Groscurth P, Lipp HP, Lu B, El Mouedden M, Mercken M, Nitsch RM, Mohajeri MH. Lack of neprilysin suffices to generate murine amyloid-like deposits in the brain and behavioral deficit in vivo. Journal of Neuroscience Research. 84: 1871-8. PMID 16998901 DOI: 10.1002/jnr.21074  1
2006 Pennanen L, Wolfer DP, Nitsch RM, Götz J. Impaired spatial reference memory and increased exploratory behavior in P301L tau transgenic mice. Genes, Brain, and Behavior. 5: 369-79. PMID 16879631 DOI: 10.1111/j.1601-183X.2005.00165.x  1
2006 Avila J, Nitsch RM, Haass C, De Strooper B. European Alzheimer disease funding. Nature Medicine. 12: 776-7. PMID 16829945 DOI: 10.1038/nm0706-776  1
2006 Wollmer MA, Kapaki E, Hersberger M, Muntwyler J, Brunner F, Tsolaki M, Akatsu H, Kosaka K, Michikawa M, Molyva D, Paraskevas GP, Lütjohann D, von Eckardstein A, Hock C, Nitsch RM, et al. Ethnicity-dependent genetic association of ABCA2 with sporadic Alzheimer's disease. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 141: 534-6. PMID 16752360 DOI: 10.1002/ajmg.b.30345  1
2006 Crameri A, Biondi E, Kuehnle K, Lütjohann D, Thelen KM, Perga S, Dotti CG, Nitsch RM, Ledesma MD, Mohajeri MH. The role of seladin-1/DHCR24 in cholesterol biosynthesis, APP processing and Abeta generation in vivo. The Embo Journal. 25: 432-43. PMID 16407971 DOI: 10.1038/sj.emboj.7600938  1
2006 Kulic L, Kurosinski P, Chen F, Tracy J, Mohajeri MH, Li H, Nitsch RM, Götz J. Active immunization trial in Abeta42-injected P301L tau transgenic mice. Neurobiology of Disease. 22: 50-6. PMID 16289870 DOI: 10.1016/j.nbd.2005.10.002  1
2005 Hock C, Nitsch RM. Clinical observations with AN-1792 using TAPIR analyses. Neuro-Degenerative Diseases. 2: 273-6. PMID 16909009 DOI: 10.1159/000090368  1
2005 Papassotiropoulos A, Lambert JC, Wavrant-De Vrièze F, Wollmer MA, von der Kammer H, Streffer JR, Maddalena A, Huynh KD, Wolleb S, Lutjohann D, Schneider B, Thal DR, Grimaldi LM, Tsolaki M, Kapaki E, ... ... Nitsch RM, et al. Cholesterol 25-hydroxylase on chromosome 10q is a susceptibility gene for sporadic Alzheimer's disease. Neuro-Degenerative Diseases. 2: 233-41. PMID 16909003 DOI: 10.1159/000090362  1
2005 Bosshardt S, Schmidt CF, Jaermann T, Degonda N, Boesiger P, Nitsch RM, Hock C, Henke K. Effects of memory consolidation on human hippocampal activity during retrieval. Cortex; a Journal Devoted to the Study of the Nervous System and Behavior. 41: 486-98. PMID 16042025  1
2005 Bosshardt S, Degonda N, Schmidt CF, Boesiger P, Nitsch RM, Hock C, Henke K. One month of human memory consolidation enhances retrieval-related hippocampal activity. Hippocampus. 15: 1026-40. PMID 16015623 DOI: 10.1002/hipo.20105  1
2005 Papassotiropoulos A, Wollmer MA, Tsolaki M, Brunner F, Molyva D, Lütjohann D, Nitsch RM, Hock C. A cluster of cholesterol-related genes confers susceptibility for Alzheimer's disease. The Journal of Clinical Psychiatry. 66: 940-7. PMID 16013913  1
2005 Papassotiropoulos A, Wollmer MA, Aguzzi A, Hock C, Nitsch RM, de Quervain DJ. The prion gene is associated with human long-term memory. Human Molecular Genetics. 14: 2241-6. PMID 15987701 DOI: 10.1093/hmg/ddi228  1
2005 Glatzel M, Mohajeri MH, Poirier R, Nitsch RM, Schwarz P, Lu B, Aguzzi A. No influence of amyloid-beta-degrading neprilysin activity on prion pathogenesis. The Journal of General Virology. 86: 1861-7. PMID 15914866 DOI: 10.1099/vir.0.80811-0  1
2005 Papassotiropoulos A, Henke K, Aerni A, Coluccia D, Garcia E, Wollmer MA, Huynh KD, Monsch AU, Stähelin HB, Hock C, Nitsch RM, de Quervain DJ. Age-dependent effects of the 5-hydroxytryptamine-2a-receptor polymorphism (His452Tyr) on human memory. Neuroreport. 16: 839-42. PMID 15891581 DOI: 10.1097/00001756-200505310-00012  1
2005 Degonda N, Mondadori CR, Bosshardt S, Schmidt CF, Boesiger P, Nitsch RM, Hock C, Henke K. Implicit associative learning engages the hippocampus and interacts with explicit associative learning. Neuron. 46: 505-20. PMID 15882649 DOI: 10.1016/j.neuron.2005.02.030  1
2005 von Rotz RC, Kins S, Hipfel R, von der Kammer H, Nitsch RM. The novel cytosolic RING finger protein dactylidin is up-regulated in brains of patients with Alzheimer's disease. The European Journal of Neuroscience. 21: 1289-98. PMID 15813938 DOI: 10.1111/j.1460-9568.2005.03977.x  1
2005 Kohli BM, Eng JK, Nitsch RM, Konietzko U. An alternative sampling algorithm for use in liquid chromatography/tandem mass spectrometry experiments. Rapid Communications in Mass Spectrometry : Rcm. 19: 589-96. PMID 15685682 DOI: 10.1002/rcm.1827  1
2005 Gaugler MN, Tracy J, Kuhnle K, Crameri A, Nitsch RM, Mohajeri MH. Modulation of Alzheimer's pathology by cerebro-ventricular grafting of hybridoma cells expressing antibodies against Abeta in vivo. Febs Letters. 579: 753-6. PMID 15670841 DOI: 10.1016/j.febslet.2005.01.002  1
2005 Umbricht D, Vyssotki D, Latanov A, Nitsch R, Lipp HP. Deviance-related electrophysiological activity in mice: is there mismatch negativity in mice? Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology. 116: 353-63. PMID 15661113 DOI: 10.1016/j.clinph.2004.08.015  1
2005 Papassotiropoulos A, Tsolaki M, Wollmer MA, Molyva D, Thal DR, Huynh KD, Tracy J, Staehelin HB, Monsch AU, Nitsch RM, Hock C. No association of a non-synonymous PLAU polymorphism with Alzheimer's disease and disease-related traits. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 132: 21-3. PMID 15558716 DOI: 10.1002/ajmg.b.30103  1
2005 Nitsch RM. The role of ß-amyloid in Alzheimer's disease Neurodegenerative Diseases: Neurobiology, Pathogenesis and Therapeutics. 452-458. DOI: 10.1017/CBO9780511544873.032  1
2004 Maddalena AS, Papassotiropoulos A, Gonzalez-Agosti C, Signorell A, Hegi T, Pasch T, Nitsch RM, Hock C. Cerebrospinal fluid profile of amyloid beta peptides in patients with Alzheimer's disease determined by protein biochip technology. Neuro-Degenerative Diseases. 1: 231-5. PMID 16908995 DOI: 10.1159/000080991  1
2004 Mohajeri MH, Gaugler MN, Martinez J, Tracy J, Li H, Crameri A, Kuehnle K, Wollmer MA, Nitsch RM. Assessment of the bioactivity of antibodies against beta-amyloid peptide in vitro and in vivo. Neuro-Degenerative Diseases. 1: 160-7. PMID 16908985 DOI: 10.1159/000080981  1
2004 Koller MF, Mohajeri MH, Huber M, Wollmer MA, Roth Z'graggen BV, Sandmeier E, Moritz E, Tracy J, Nitsch RM, Christen P. Active immunization of mice with an Abeta-Hsp70 vaccine. Neuro-Degenerative Diseases. 1: 20-8. PMID 16908970 DOI: 10.1159/000076666  1
2004 Repetto E, Russo C, Venezia V, Nizzari M, Nitsch RM, Schettini G. BACE1 overexpression regulates amyloid precursor protein cleavage and interaction with the ShcA adapter. Annals of the New York Academy of Sciences. 1030: 330-8. PMID 15659814 DOI: 10.1196/annals.1329.041  1
2004 Wolfer DP, Litvin O, Morf S, Nitsch RM, Lipp HP, Würbel H. Laboratory animal welfare: cage enrichment and mouse behaviour. Nature. 432: 821-2. PMID 15602544 DOI: 10.1038/432821a  1
2004 Nitsch RM. Immunotherapy of Alzheimer disease. Alzheimer Disease and Associated Disorders. 18: 185-9. PMID 15592128  1
2004 Grasbon-Frodl E, Lorenz H, Mann U, Nitsch RM, Windl O, Kretzschmar HA. Loss of glycosylation associated with the T183A mutation in human prion disease. Acta Neuropathologica. 108: 476-84. PMID 15558291 DOI: 10.1007/s00401-004-0913-4  1
2004 Günther C, von Hadeln K, Müller-Thomsen T, Alberici A, Binetti G, Hock C, Nitsch RM, Stoppe G, Reiss J, Gal A, Finckh U. Possible association of mitochondrial transcription factor A (TFAM) genotype with sporadic Alzheimer disease. Neuroscience Letters. 369: 219-23. PMID 15464268 DOI: 10.1016/j.neulet.2004.07.070  1
2004 von Rotz RC, Kohli BM, Bosset J, Meier M, Suzuki T, Nitsch RM, Konietzko U. The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor. Journal of Cell Science. 117: 4435-48. PMID 15331662 DOI: 10.1242/jcs.01323  1
2004 Umbricht D, Vyssotky D, Latanov A, Nitsch R, Brambilla R, D'Adamo P, Lipp HP. Midlatency auditory event-related potentials in mice: comparison to midlatency auditory ERPs in humans. Brain Research. 1019: 189-200. PMID 15306253 DOI: 10.1016/j.brainres.2004.05.097  1
2004 Aerni A, Traber R, Hock C, Roozendaal B, Schelling G, Papassotiropoulos A, Nitsch RM, Schnyder U, de Quervain DJ. Low-dose cortisol for symptoms of posttraumatic stress disorder. The American Journal of Psychiatry. 161: 1488-90. PMID 15285979 DOI: 10.1176/appi.ajp.161.8.1488  1
2004 Mohajeri MH, Madani R, Saini K, Lipp HP, Nitsch RM, Wolfer DP. The impact of genetic background on neurodegeneration and behavior in seizured mice. Genes, Brain, and Behavior. 3: 228-39. PMID 15248868 DOI: 10.1111/j.1601-1848.2004.00073.x  1
2004 Schiltz JG, Salzer U, Mohajeri MH, Franke D, Heinrich J, Pavlovic J, Wollmer MA, Nitsch RM, Moelling K. Antibodies from a DNA peptide vaccination decrease the brain amyloid burden in a mouse model of Alzheimer's disease. Journal of Molecular Medicine (Berlin, Germany). 82: 706-14. PMID 15241501 DOI: 10.1007/s00109-004-0570-z  1
2004 Greeve I, Kretzschmar D, Tschäpe JA, Beyn A, Brellinger C, Schweizer M, Nitsch RM, Reifegerste R. Age-dependent neurodegeneration and Alzheimer-amyloid plaque formation in transgenic Drosophila. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 3899-906. PMID 15102905 DOI: 10.1523/JNEUROSCI.0283-04.2004  1
2004 Pennanen L, Welzl H, D'Adamo P, Nitsch RM, Götz J. Accelerated extinction of conditioned taste aversion in P301L tau transgenic mice. Neurobiology of Disease. 15: 500-9. PMID 15056457 DOI: 10.1016/j.nbd.2003.11.020  1
2004 Mohajeri MH, Kuehnle K, Li H, Poirier R, Tracy J, Nitsch RM. Anti-amyloid activity of neprilysin in plaque-bearing mouse models of Alzheimer's disease. Febs Letters. 562: 16-21. PMID 15043995 DOI: 10.1016/S0014-5793(04)00169-3  1
2004 Mohajeri MH, Saini KD, Nitsch RM. Transgenic BACE expression in mouse neurons accelerates amyloid plaque pathology. Journal of Neural Transmission (Vienna, Austria : 1996). 111: 413-25. PMID 14991462 DOI: 10.1007/s00702-003-0057-z  1
2004 de Quervain DJ, Poirier R, Wollmer MA, Grimaldi LM, Tsolaki M, Streffer JR, Hock C, Nitsch RM, Mohajeri MH, Papassotiropoulos A. Glucocorticoid-related genetic susceptibility for Alzheimer's disease. Human Molecular Genetics. 13: 47-52. PMID 14583441 DOI: 10.1093/hmg/ddg361  1
2004 Hock C, Nitsch RM. Neurodegenerative diseases: From the patients to the lab and back again Neurodegenerative Diseases. 1: 1-2. DOI: 10.1159/000076663  1
2003 de Quervain DJ, Henke K, Aerni A, Coluccia D, Wollmer MA, Hock C, Nitsch RM, Papassotiropoulos A. A functional genetic variation of the 5-HT2a receptor affects human memory. Nature Neuroscience. 6: 1141-2. PMID 14566344 DOI: 10.1038/nn1146  1
2003 Maddalena A, Papassotiropoulos A, Müller-Tillmanns B, Jung HH, Hegi T, Nitsch RM, Hock C. Biochemical diagnosis of Alzheimer disease by measuring the cerebrospinal fluid ratio of phosphorylated tau protein to beta-amyloid peptide42. Archives of Neurology. 60: 1202-6. PMID 12975284 DOI: 10.1001/archneur.60.9.1202  1
2003 Kins S, Kurosinski P, Nitsch RM, Götz J. Activation of the ERK and JNK signaling pathways caused by neuron-specific inhibition of PP2A in transgenic mice. The American Journal of Pathology. 163: 833-43. PMID 12937125 DOI: 10.1016/S0002-9440(10)63444-X  1
2003 Finckh U, van Hadeln K, Müller-Thomsen T, Alberici A, Binetti G, Hock C, Nitsch RM, Stoppe G, Reiss J, Gal A. Association of late-onset Alzheimer disease with a genotype of PLAU, the gene encoding urokinase-type plasminogen activator on chromosome 10q22.2. Neurogenetics. 4: 213-7. PMID 12898287 DOI: 10.1007/s10048-003-0157-9  1
2003 Ferrari A, Hoerndli F, Baechi T, Nitsch RM, Götz J. beta-Amyloid induces paired helical filament-like tau filaments in tissue culture. The Journal of Biological Chemistry. 278: 40162-8. PMID 12893817 DOI: 10.1074/jbc.M308243200  1
2003 Wollmer MA, Streffer JR, Tsolaki M, Grimaldi LM, Lütjohann D, Thal D, von Bergmann K, Nitsch RM, Hock C, Papassotiropoulos A. Genetic association of acyl-coenzyme A: cholesterol acyltransferase with cerebrospinal fluid cholesterol levels, brain amyloid load, and risk for Alzheimer's disease. Molecular Psychiatry. 8: 635-8. PMID 12851640 DOI: 10.1038/sj.mp.4001296  1
2003 Henke K, Treyer V, Weber B, Nitsch RM, Hock C, Wieser HG, Buck A. Functional neuroimaging predicts individual memory outcome after amygdalohippocampectomy. Neuroreport. 14: 1197-202. PMID 12824759 DOI: 10.1097/01.wnr.0000081865.45938.64  1
2003 Hock C, Konietzko U, Streffer JR, Tracy J, Signorell A, Müller-Tillmanns B, Lemke U, Henke K, Moritz E, Garcia E, Wollmer MA, Umbricht D, de Quervain DJ, Hofmann M, Maddalena A, ... ... Nitsch RM, et al. Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease. Neuron. 38: 547-54. PMID 12765607 DOI: 10.1016/S0896-6273(03)00294-0  1
2003 Hock C, Maddalena A, Raschig A, Müller-Spahn F, Eschweiler G, Hager K, Heuser I, Hampel H, Müller-Thomsen T, Oertel W, Wienrich M, Signorell A, Gonzalez-Agosti C, Nitsch RM. Treatment with the selective muscarinic m1 agonist talsaclidine decreases cerebrospinal fluid levels of A beta 42 in patients with Alzheimer's disease. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 10: 1-6. PMID 12762134  1
2003 Benussi L, Ghidoni R, Steinhoff T, Alberici A, Villa A, Mazzoli F, Nicosia F, Barbiero L, Broglio L, Feudatari E, Signorini S, Finckh U, Nitsch RM, Binetti G. Alzheimer disease-associated cystatin C variant undergoes impaired secretion. Neurobiology of Disease. 13: 15-21. PMID 12758063 DOI: 10.1016/S0969-9961(03)00012-3  1
2003 Mohajeri MH, Saini K, Li H, Crameri A, Lipp HP, Wolfer DP, Nitsch RM. Intact spatial memory in mice with seizure-induced partial loss of hippocampal pyramidal neurons. Neurobiology of Disease. 12: 174-81. PMID 12742738 DOI: 10.1016/S0969-9961(02)00031-1  1
2003 de Quervain DJ, Henke K, Aerni A, Treyer V, McGaugh JL, Berthold T, Nitsch RM, Buck A, Roozendaal B, Hock C. Glucocorticoid-induced impairment of declarative memory retrieval is associated with reduced blood flow in the medial temporal lobe. The European Journal of Neuroscience. 17: 1296-302. PMID 12670318 DOI: 10.1046/j.1460-9568.2003.02542.x  1
2003 Henke K, Mondadori CR, Treyer V, Nitsch RM, Buck A, Hock C. Nonconscious formation and reactivation of semantic associations by way of the medial temporal lobe. Neuropsychologia. 41: 863-76. PMID 12667523 DOI: 10.1016/S0028-3932(03)00035-6  1
2003 Henke K, Treyer V, Nagy ET, Kneifel S, Dürsteler M, Nitsch RM, Buck A. Active hippocampus during nonconscious memories. Consciousness and Cognition. 12: 31-48. PMID 12617861 DOI: 10.1016/S1053-8100(02)00006-5  1
2003 Wollmer MA, Streffer JR, Lütjohann D, Tsolaki M, Iakovidou V, Hegi T, Pasch T, Jung HH, Bergmann Kv, Nitsch RM, Hock C, Papassotiropoulos A. ABCA1 modulates CSF cholesterol levels and influences the age at onset of Alzheimer's disease. Neurobiology of Aging. 24: 421-6. PMID 12600718 DOI: 10.1016/S0197-4580(02)00094-5  1
2003 Streffer JR, Papassotiropoulos A, Kurosinski P, Signorell A, Wollmer MA, Tsolaki M, Iakovidou V, Hörndli F, Bosset J, Götz J, Nitsch RM, Hock C. Saitohin gene is not associated with Alzheimer's disease. Journal of Neurology, Neurosurgery, and Psychiatry. 74: 362-3. PMID 12588928 DOI: 10.1136/jnnp.74.3.362  1
2003 Papassotiropoulos A, Streffer JR, Tsolaki M, Schmid S, Thal D, Nicosia F, Iakovidou V, Maddalena A, Lütjohann D, Ghebremedhin E, Hegi T, Pasch T, Träxler M, Brühl A, Benussi L, ... ... Nitsch RM, et al. Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with an intronic CYP46 polymorphism. Archives of Neurology. 60: 29-35. PMID 12533085  1
2002 Schmidt K, Kins S, Schild A, Nitsch RM, Hemmings BA, Götz J. Diversity, developmental regulation and distribution of murine PR55/B subunits of protein phosphatase 2A. The European Journal of Neuroscience. 16: 2039-48. PMID 12473071 DOI: 10.1046/j.1460-9568.2002.02274.x  1
2002 Hock C, Konietzko U, Papassotiropoulos A, Wollmer A, Streffer J, von Rotz RC, Davey G, Moritz E, Nitsch RM. Generation of antibodies specific for beta-amyloid by vaccination of patients with Alzheimer disease. Nature Medicine. 8: 1270-5. PMID 12379846 DOI: 10.1038/nm783  1
2002 Wollmer MA, Papassotiropoulos A, Streffer JR, Grimaldi LM, Kapaki E, Salani G, Paraskevas GP, Maddalena A, de Quervain D, Bieber C, Umbricht D, Lemke U, Bosshardt S, Degonda N, Henke K, ... ... Nitsch RM, et al. Genetic polymorphisms and cerebrospinal fluid levels of tissue inhibitor of metalloproteinases 1 in sporadic Alzheimer's disease. Psychiatric Genetics. 12: 155-60. PMID 12218659 DOI: 10.1097/00041444-200209000-00006  1
2002 Mohajeri MH, Wollmer MA, Nitsch RM. Abeta 42-induced increase in neprilysin is associated with prevention of amyloid plaque formation in vivo. The Journal of Biological Chemistry. 277: 35460-5. PMID 12105192 DOI: 10.1074/jbc.M202899200  1
2002 Mohajeri MH, Saini K, Schultz JG, Wollmer MA, Hock C, Nitsch RM. Passive immunization against beta-amyloid peptide protects central nervous system (CNS) neurons from increased vulnerability associated with an Alzheimer's disease-causing mutation. The Journal of Biological Chemistry. 277: 33012-7. PMID 12068009 DOI: 10.1074/jbc.M203193200  1
2002 Buss S, Müller-Thomsen T, Hock C, Alberici A, Binetti G, Nitsch RM, Gal A, Finckh U. No association between DCP1 genotype and late-onset Alzheimer disease. American Journal of Medical Genetics. 114: 440-5. PMID 11992568 DOI: 10.1002/ajmg.10306  1
2002 Zurdel J, Finckh U, Menzer G, Nitsch RM, Richard G. CST3 genotype associated with exudative age related macular degeneration. The British Journal of Ophthalmology. 86: 214-9. PMID 11815350 DOI: 10.1136/bjo.86.2.214  1
2001 Papassotiropoulos A, Hock C, Nitsch RM. Genetics of interleukin 6: implications for Alzheimer's disease. Neurobiology of Aging. 22: 863-71. PMID 11754993 DOI: 10.1016/S0197-4580(01)00294-9  1
2001 Benussi L, Alberici A, Mayhaus M, Langer U, Ghidoni R, Mazzoli F, Nicosia F, Barbiero L, Frisoni G, Zanetti O, Gasparini L, Nitsch RM, Binetti G. Detection of the presenilin 1 COOH-terminal fragment in the extracellular compartment: a release enhanced by apoptosis. Experimental Cell Research. 269: 256-65. PMID 11570818 DOI: 10.1006/excr.2001.5329  1
2001 Deng A, Irizarry MC, Nitsch RM, Growdon JH, Rebeck GW. Elevation of cystatin C in susceptible neurons in Alzheimer's disease. The American Journal of Pathology. 159: 1061-8. PMID 11549598 DOI: 10.1016/S0002-9440(10)61781-6  1
2001 Götz J, Chen F, van Dorpe J, Nitsch RM. Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils. Science (New York, N.Y.). 293: 1491-5. PMID 11520988 DOI: 10.1126/science.1062097  1
2001 Steinhoff T, Moritz E, Wollmer MA, Mohajeri MH, Kins S, Nitsch RM. Increased cystatin C in astrocytes of transgenic mice expressing the K670N-M671L mutation of the amyloid precursor protein and deposition in brain amyloid plaques. Neurobiology of Disease. 8: 647-54. PMID 11493029 DOI: 10.1006/nbdi.2001.0412  1
2001 Kins S, Crameri A, Evans DR, Hemmings BA, Nitsch RM, Gotz J. Reduced protein phosphatase 2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice. The Journal of Biological Chemistry. 276: 38193-200. PMID 11473109 DOI: 10.1074/jbc.M102621200  1
2001 von der Kammer H, Demiralay C, Andresen B, Albrecht C, Mayhaus M, Nitsch RM. Regulation of gene expression by muscarinic acetylcholine receptors. Biochemical Society Symposium. 131-40. PMID 11447829  1
2001 Götz J, Nitsch RM. Compartmentalized tau hyperphosphorylation and increased levels of kinases in transgenic mice. Neuroreport. 12: 2007-16. PMID 11435938  1
2001 Götz J, Tolnay M, Barmettler R, Chen F, Probst A, Nitsch RM. Oligodendroglial tau filament formation in transgenic mice expressing G272V tau. The European Journal of Neuroscience. 13: 2131-40. PMID 11422454 DOI: 10.1046/j.0953-816X.2001.01604.x  1
2001 Götz J, Tolnay M, Barmettler R, Ferrari A, Bürki K, Goedert M, Probst A, Nitsch RM. Human tau transgenic mice. Towards an animal model for neuro- and glialfibrillary lesion formation. Advances in Experimental Medicine and Biology. 487: 71-83. PMID 11403167  1
2001 Menzer G, Müller-Thomsen T, Meins W, Alberici A, Binetti G, Hock C, Nitsch RM, Stoppe G, Reiss J, Finckh U. Non-replication of association between cathepsin D genotype and late onset Alzheimer disease. American Journal of Medical Genetics. 105: 179-82. PMID 11304834 DOI: 10.1002/ajmg.1204  1
2001 Götz J, Chen F, Barmettler R, Nitsch RM. Tau filament formation in transgenic mice expressing P301L tau. The Journal of Biological Chemistry. 276: 529-34. PMID 11013246 DOI: 10.1074/jbc.M006531200  1
2001 Papassotiropoulos A, Streffer JR, Hock C, Nitsch RM. Genetics of Alzheimer's disease Schweizer Archiv Fur Neurologie Und Psychiatrie. 152: 278-287.  1
2000 von der Kammer H, Mayhaus M, Albrecht C, Andresen B, Klaudiny J, Demiralay C, Nitsch RM. Regulation of gene expression by muscarinic acetylcholine receptors. A comprehensive approach for the identification of regulated genes. Annals of the New York Academy of Sciences. 920: 305-8. PMID 11193168  1
2000 Hock C, Maddalena A, Heuser I, Naber D, Oertel W, von der Kammer H, Wienrich M, Raschig A, Deng M, Growdon JH, Nitsch RM. Treatment with the selective muscarinic agonist talsaclidine decreases cerebrospinal fluid levels of total amyloid beta-peptide in patients with Alzheimer's disease. Annals of the New York Academy of Sciences. 920: 285-91. PMID 11193166  1
2000 Götz J, Barmettler R, Ferrari A, Goedert M, Probst A, Nitsch RM. In vivo analysis of wild-type and FTDP-17 tau transgenic mice. Annals of the New York Academy of Sciences. 920: 126-33. PMID 11193141  1
2000 Finckh U, Müller-Thomsen T, Mann U, Eggers C, Marksteiner J, Meins W, Binetti G, Alberici A, Sonderegger P, Hock C, Nitsch RM, Gal A. High frequency of mutations in four different disease genes in early-onset dementia. Annals of the New York Academy of Sciences. 920: 100-6. PMID 11193137  1
2000 Nitsch RM, Deng M, Tennis M, Schoenfeld D, Growdon JH. The selective muscarinic M1 agonist AF102B decreases levels of total Abeta in cerebrospinal fluid of patients with Alzheimer's disease. Annals of Neurology. 48: 913-8. PMID 11117548 DOI: 10.1002/1531-8249(200012)48:6<913::AID-ANA12>3.0.CO;2-S  1
2000 Ferrari A, Ehler E, Nitsch RM, Götz J. Immature human NT2 cells grafted into mouse brain differentiate into neuronal and glial cell types. Febs Letters. 486: 121-5. PMID 11113451 DOI: 10.1016/S0014-5793(00)02251-1  1
2000 Finckh U, von der Kammer H, Velden J, Michel T, Andresen B, Deng A, Zhang J, Müller-Thomsen T, Zuchowski K, Menzer G, Mann U, Papassotiropoulos A, Heun R, Zurdel J, Holst F, ... ... Nitsch RM, et al. Genetic association of a cystatin C gene polymorphism with late-onset Alzheimer disease. Archives of Neurology. 57: 1579-83. PMID 11074789  1
2000 Hock C, Heese K, Müller-Spahn F, Huber P, Riesen W, Nitsch RM, Otten U. Increased cerebrospinal fluid levels of neurotrophin 3 (NT-3) in elderly patients with major depression. Molecular Psychiatry. 5: 510-3. PMID 11032384  1
2000 Greeve I, Hermans-Borgmeyer I, Brellinger C, Kasper D, Gomez-Isla T, Behl C, Levkau B, Nitsch RM. The human DIMINUTO/DWARF1 homolog seladin-1 confers resistance to Alzheimer's disease-associated neurodegeneration and oxidative stress. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 7345-52. PMID 11007892  1
2000 Croes EA, Dermaut B, van Der Cammen TJ, van Broeckhoven C, van Duijn CM. Genetic testing should not be advocated as a diagnostic tool in familial forms of dementia. American Journal of Human Genetics. 67: 1033-5. PMID 10986048 DOI: 10.1086/303074  1
2000 Hock CH, Heese K, Olivieri G, Hulette CH, Rosenberg C, Nitsch RM, Otten U. Alterations in neurotrophins and neurotrophin receptors in Alzheimer's disease. Journal of Neural Transmission. Supplementum. 59: 171-4. PMID 10961429  1
2000 Albrecht C, von Der Kammer H, Mayhaus M, Klaudiny J, Schweizer M, Nitsch RM. Muscarinic acetylcholine receptors induce the expression of the immediate early growth regulatory gene CYR61. The Journal of Biological Chemistry. 275: 28929-36. PMID 10852911 DOI: 10.1074/jbc.M003053200  1
2000 Hock C, Heese K, Müller-Spahn F, Huber P, Riesen W, Nitsch RM, Otten U. Increased CSF levels of nerve growth factor in patients with Alzheimer's disease. Neurology. 54: 2009-11. PMID 10822447  1
2000 Finckh U, Alberici A, Antoniazzi M, Benussi L, Fedi V, Giannini C, Gal A, Nitsch RM, Binetti G. Variable expression of familial Alzheimer disease associated with presenilin 2 mutation M239I. Neurology. 54: 2006-8. PMID 10822446  1
2000 Götz J, Probst A, Mistl C, Nitsch RM, Ehler E. Distinct role of protein phosphatase 2A subunit Calpha in the regulation of E-cadherin and beta-catenin during development. Mechanisms of Development. 93: 83-93. PMID 10781942 DOI: 10.1016/S0925-4773(00)00267-7  1
2000 Hock C, Nitsch RM. [Alzheimer dementia]. Praxis. 89: 529-40. PMID 10776055  1
2000 de Quervain DJ, Roozendaal B, Nitsch RM, McGaugh JL, Hock C. Acute cortisone administration impairs retrieval of long-term declarative memory in humans. Nature Neuroscience. 3: 313-4. PMID 10725918 DOI: 10.1038/73873  1
2000 Giess R, Beck M, Goetz R, Nitsch RM, Toyka KV, Sendtner M. Potential role of LIF as a modifier gene in the pathogenesis of amyotrophic lateral sclerosis. Neurology. 54: 1003-5. PMID 10691006  1
2000 Finckh U, Müller-Thomsen T, Mann U, Eggers C, Marksteiner J, Meins W, Binetti G, Alberici A, Hock C, Nitsch RM, Gal A. High prevalence of pathogenic mutations in patients with early-onset dementia detected by sequence analyses of four different genes. American Journal of Human Genetics. 66: 110-7. PMID 10631141 DOI: 10.1086/302702  1
2000 Growdon JH, Wurtman RJ, Corkin S, Nitsch RM. The molecular basis of dementia: Preface Annals of the New York Academy of Sciences. 920: xi-xii.  1
1999 Gasparini L, Ghidoni R, Alberici AC, Benussi L, Moratto D, Trabucchi M, Growdon JH, Nitsch RM, Binetti G. Modulation of presenilin-1 processing by nitric oxide during apoptosis induced by serum withdrawal and glucose deprivation. Annals of the New York Academy of Sciences. 893: 294-7. PMID 10672252  1
1999 Alberici A, Moratto D, Benussi L, Gasparini L, Ghidoni R, Gatta LB, Finazzi D, Frisoni GB, Trabucchi M, Growdon JH, Nitsch RM, Binetti G. Presenilin 1 protein directly interacts with Bcl-2. The Journal of Biological Chemistry. 274: 30764-9. PMID 10521466 DOI: 10.1074/jbc.274.43.30764  1
1999 von der Kammer H, Albrecht C, Mayhaus M, Hoffmann B, Stanke G, Nitsch RM. Identification of genes regulated by muscarinic acetylcholine receptors: application of an improved and statistically comprehensive mRNA differential display technique. Nucleic Acids Research. 27: 2211-8. PMID 10219095 DOI: 10.1093/nar/27.10.2211  1
1998 Müller D, Nitsch RM, Wurtman RJ, Hoyer S. Streptozotocin increases free fatty acids and decreases phospholipids in rat brain. Journal of Neural Transmission (Vienna, Austria : 1996). 105: 1271-81. PMID 9928896 DOI: 10.1007/s007020050130  1
1998 Müller D, Wiegmann H, Langer U, Moltzen-Lenz S, Nitsch RM. Lu 25-109, a combined m1 agonist and m2 antagonist, modulates regulated processing of the amyloid precursor protein of Alzheimer's disease. Journal of Neural Transmission (Vienna, Austria : 1996). 105: 1029-43. PMID 9869334 DOI: 10.1007/s007020050110  1
1998 Liao A, Nitsch RM, Greenberg SM, Finckh U, Blacker D, Albert M, Rebeck GW, Gomez-Isla T, Clatworthy A, Binetti G, Hock C, Mueller-Thomsen T, Mann U, Zuchowski K, Beisiegel U, et al. Genetic association of an alpha2-macroglobulin (Val1000lle) polymorphism and Alzheimer's disease. Human Molecular Genetics. 7: 1953-6. PMID 9811940 DOI: 10.1093/hmg/7.12.1953  1
1998 Nitsch RM, Rossner S, Albrecht C, Mayhaus M, Enderich J, Schliebs R, Wegner M, Arendt T, von der Kammer H. Muscarinic acetylcholine receptors activate the acetylcholinesterase gene promoter. Journal of Physiology, Paris. 92: 257-64. PMID 9789819 DOI: 10.1016/S0928-4257(98)80029-6  1
1998 Hock C, Drasch G, Golombowski S, Müller-Spahn F, Willershausen-Zönnchen B, Schwarz P, Hock U, Growdon JH, Nitsch RM. Increased blood mercury levels in patients with Alzheimer's disease. Journal of Neural Transmission (Vienna, Austria : 1996). 105: 59-68. PMID 9588761 DOI: 10.1007/s007020050038  1
1998 Nitsch RM, Kim C, Growdon JH. Vasopressin and bradykinin regulate secretory processing of the amyloid protein precursor of Alzheimer's disease. Neurochemical Research. 23: 807-14. PMID 9566621 DOI: 10.1023/A:1022423813362  1
1998 Hock C, Golombowski S, Müller-Spahn F, Naser W, Beyreuther K, Mönning U, Schenk D, Vigo-Pelfrey C, Bush AM, Moir R, Tanzi RE, Growdon JH, Nitsch RM. Cerebrospinal fluid levels of amyloid precursor protein and amyloid beta-peptide in Alzheimer's disease and major depression - inverse correlation with dementia severity. European Neurology. 39: 111-8. PMID 9520072 DOI: 10.1159/000007917  1
1998 Finckh U, Mann U, Muller-Thomsen T, Eggers C, Naber D, Nitsch RM, Gal A. Unexpected spectrum of disease-causing mutations in a clinical sample of patients with presenile dementia American Journal of Medical Genetics - Neuropsychiatric Genetics. 81: 554-555.  1
1997 Johannsen J, Nitsch RM, Oswald WD, Reischies FM, Rieder H. [Aging as a chance--aging as a risk]. Zeitschrift FüR Gerontologie Und Geriatrie. 30: 480-5. PMID 9499491  1
1997 Nitsch RM, Deng A, Wurtman RJ, Growdon JH. Metabotropic glutamate receptor subtype mGluR1alpha stimulates the secretion of the amyloid beta-protein precursor ectodomain. Journal of Neurochemistry. 69: 704-12. PMID 9231730  1
1997 Müller DM, Mendla K, Farber SA, Nitsch RM. Muscarinic M1 receptor agonists increase the secretion of the amyloid precursor protein ectodomain. Life Sciences. 60: 985-91. PMID 9121365 DOI: 10.1016/S0024-3205(97)00038-6  1
1997 Von Dor Kammer H, Mayhaus M, Alhrecht C, Klaudiny J, Nitsch RM. Identification of inducible genes by transcriptional activation with muscarinic acetylcholine receptors Faseb Journal. 11: A1059.  1
1997 Albrecht C, Yon Der Kammer H, Mayhaus M, Klaudiny, Nitsch RM. GIG-1: A g protein-coupled receptor induced gene Faseb Journal. 11: A1168.  1
1996 Nitsch RM. From acetylcholine to amyloid: neurotransmitters and the pathology of Alzheimer's disease. Neurodegeneration : a Journal For Neurodegenerative Disorders, Neuroprotection, and Neuroregeneration. 5: 477-82. PMID 9117566 DOI: 10.1006/neur.1996.0066  1
1996 Nitsch RM, Deng M, Growdon JH, Wurtman RJ. Serotonin 5-HT2a and 5-HT2c receptors stimulate amyloid precursor protein ectodomain secretion. The Journal of Biological Chemistry. 271: 4188-94. PMID 8626761 DOI: 10.1074/jbc.271.8.4188  1
1996 Nitsch RM, Wurtman RJ, Growdon JH. Regulation of APP processing. Potential for the therapeutical reduction of brain amyloid burden. Annals of the New York Academy of Sciences. 777: 175-82. PMID 8624081  1
1995 Nitsch RM, Wurtman RJ, Growdon JH. Regulation of proteolytic processing of the amyloid beta-protein precursor by first messengers. A novel potential approach for the treatment of Alzheimer's disease. Arzneimittel-Forschung. 45: 435-8. PMID 7763340  1
1995 Nitsch RM, Rebeck GW, Deng M, Richardson UI, Tennis M, Schenk DB, Vigo-Pelfrey C, Lieberburg I, Wurtman RJ, Hyman BT. Cerebrospinal fluid levels of amyloid beta-protein in Alzheimer's disease: inverse correlation with severity of dementia and effect of apolipoprotein E genotype. Annals of Neurology. 37: 512-8. PMID 7717688 DOI: 10.1002/ana.410370414  1
1995 Lee RK, Wurtman RJ, Cox AJ, Nitsch RM. Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors. Proceedings of the National Academy of Sciences of the United States of America. 92: 8083-7. PMID 7644542 DOI: 10.1073/pnas.92.17.8083  1
1995 Farber SA, Nitsch RM, Schulz JG, Wurtman RJ. Regulated secretion of beta-amyloid precursor protein in rat brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 7442-51. PMID 7472496  1
1995 Nitsch RM, Marinescu V, Postle BR, Corkin S, Wurtman RJ. Eight Meeting of the International Study Group on the Pharmacology of Memory Disorders Associated with Aging. The Neurobiology of Alzheimer's Disease, Zurich, Switzerland, February 17-19, 1995 Amyloid. 2: 204-212. DOI: 10.3109/13506129509036928  1
1995 Nitsch RM, Postle B, Marinescu V, Wurtman RJ. Biological mechanisms in the pathogenesis and cure of AD Drug News and Perspectives. 8: 181-188.  1
1994 Dutschke K, Nitsch RM, Hoyer S. Short-term mental activation accelerates the age-related decline of high-energy phosphates in rat cerebral cortex. Archives of Gerontology and Geriatrics. 19: 43-51. PMID 15374293 DOI: 10.1016/0167-4943(94)90024-8  1
1994 Nitsch RM, Growdon JH. Role of neurotransmission in the regulation of amyloid beta-protein precursor processing. Biochemical Pharmacology. 47: 1275-84. PMID 7910457 DOI: 10.1016/0006-2952(94)90325-5  1
1994 Nitsch RM, Slack BE, Farber SA, Schulz JG, Deng M, Kim C, Borghesani PR, Korver W, Wurtman RJ, Growdon JH. Regulation of proteolytic processing of the amyloid beta-protein precursor of Alzheimer's disease in transfected cell lines and in brain slices. Journal of Neural Transmission. Supplementum. 44: 21-7. PMID 7897393  1
1993 Nitsch RM, Farber SA, Growdon JH, Wurtman RJ. Release of amyloid beta-protein precursor derivatives by electrical depolarization of rat hippocampal slices. Proceedings of the National Academy of Sciences of the United States of America. 90: 5191-3. PMID 8506366  1
1993 Slack BE, Nitsch RM, Livneh E, Kunz GM, Breu J, Eldar H, Wurtman RJ. Regulation by phorbol esters of amyloid precursor protein release from Swiss 3T3 fibroblasts overexpressing protein kinase C alpha. The Journal of Biological Chemistry. 268: 21097-101. PMID 8407946  1
1993 Nitsch RM, Blusztajn JK, Doyle FM, Robitaille Y, Wurtman RJ, Growdon JH, Kish SJ. Phospholipid metabolite levels are altered in cerebral cortex of patients with dominantly inherited olivopontocerebellar atrophy. Neuroscience Letters. 161: 191-4. PMID 8272265 DOI: 10.1016/0304-3940(93)90291-R  1
1993 Holmes TC, Nitsch RM, Erfurth A, Wurtman RJ. Phospholipid and phospholipid metabolites in rat frontal cortex are decreased following nucleus basalis lesions. Annals of the New York Academy of Sciences. 695: 241-3. PMID 8239290 DOI: 10.1111/j.1749-6632.1993.tb23060.x  1
1993 Slack BE, Nitsch RM, Livneh E, Kunz GM, Eldar H, Wurtman RJ. Regulation of amyloid precursor protein release by protein kinase C in Swiss 3T3 fibroblasts. Annals of the New York Academy of Sciences. 695: 128-31. PMID 8239270 DOI: 10.1111/j.1749-6632.1993.tb23040.x  1
1993 Nitsch RM, Slack BE, Farber SA, Borghesani PR, Schulz JG, Kim C, Felder CC, Growdon JH, Wurtman RJ. Receptor-coupled amyloid precursor protein processing. Annals of the New York Academy of Sciences. 695: 122-7. PMID 8239269 DOI: 10.1111/j.1749-6632.1993.tb23039.x  1
1993 Hung AY, Haass C, Nitsch RM, Qiu WQ, Citron M, Wurtman RJ, Growdon JH, Selkoe DJ. Activation of protein kinase C inhibits cellular production of the amyloid beta-protein. The Journal of Biological Chemistry. 268: 22959-62. PMID 8226807  1
1992 Slack BE, Richardson UI, Nitsch RM, Wurtman RJ. Dioctanoylglycerol stimulates accumulation of [methyl-14C]choline and its incorporation into acetylcholine and phosphatidylcholine in a human cholinergic neuroblastoma cell line. Brain Research. 585: 169-76. PMID 1511298 DOI: 10.1016/0006-8993(92)91203-Q  1
1992 Schmahmann JD, Nitsch RM, Pandya DN. The mysterious relocation of the bundle of Türck. Brain : a Journal of Neurology. 115: 1911-24. PMID 1486468 DOI: 10.1093/brain/115.6.1911  1
1992 Nitsch RM, Slack BE, Wurtman RJ, Growdon JH. Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors. Science (New York, N.Y.). 258: 304-7. PMID 1411529  1
1992 Nitsch RM, Blusztajn JK, Pittas AG, Slack BE, Growdon JH, Wurtman RJ. Evidence for a membrane defect in Alzheimer disease brain. Proceedings of the National Academy of Sciences of the United States of America. 89: 1671-5. PMID 1311847  1
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