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Roger M. Nitsch, MD - Publications

Affiliations: 
Psychiatry Universität Zürich, Zürich, ZH, Switzerland 
Area:
Alzheimer’s disease, genetics
Website:
http://www.dpr.uzh.ch/aboutus/People/directors/nitsch.html

79 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Rust R, Weber RZ, Generali M, Kehl D, Bodenmann C, Uhr D, Wanner D, Zürcher KJ, Saito H, Hoerstrup SP, Nitsch RM, Tackenberg C. Xeno-free induced pluripotent stem cell-derived neural progenitor cells for in vivo applications. Journal of Translational Medicine. 20: 421. PMID 36114512 DOI: 10.1186/s12967-022-03610-5  0.723
2022 de Leeuw SM, Kirschner AWT, Lindner K, Rust R, Budny V, Wolski WE, Gavin AC, Nitsch RM, Tackenberg C. APOE2, E3, and E4 differentially modulate cellular homeostasis, cholesterol metabolism, and inflammatory response in isogenic iPSC-derived astrocytes. Stem Cell Reports. 17: 1229-1231. PMID 35545024 DOI: 10.1016/j.stemcr.2022.03.018  0.717
2022 Weber RZ, Bodenmann C, Uhr D, Zürcher KJ, Wanner D, Generali M, Nitsch RM, Rust R, Tackenberg C. Intracerebral Transplantation and In Vivo Bioluminescence Tracking of Human Neural Progenitor Cells in the Mouse Brain. Journal of Visualized Experiments : Jove. PMID 35156654 DOI: 10.3791/63102  0.719
2021 de Leeuw SM, Kirschner AWT, Lindner K, Rust R, Budny V, Wolski WE, Gavin AC, Nitsch RM, Tackenberg C. APOE2, E3, and E4 differentially modulate cellular homeostasis, cholesterol metabolism, and inflammatory response in isogenic iPSC-derived astrocytes. Stem Cell Reports. PMID 34919811 DOI: 10.1016/j.stemcr.2021.11.007  0.742
2020 Tackenberg C, Kulic L, Nitsch RM. Familial Alzheimer's disease mutations at position 22 of the amyloid β-peptide sequence differentially affect synaptic loss, tau phosphorylation and neuronal cell death in an ex vivo system. Plos One. 15: e0239584. PMID 32966331 DOI: 10.1371/journal.pone.0239584  0.802
2020 Kirabali T, Rust R, Rigotti S, Siccoli A, Nitsch RM, Kulic L. Distinct changes in all major components of the neurovascular unit across different neuropathological stages of Alzheimer's disease. Brain Pathology (Zurich, Switzerland). PMID 32866303 DOI: 10.1111/Bpa.12895  0.808
2020 Gericke C, Mallone A, Engelhardt B, Nitsch RM, Ferretti MT. Oligomeric Forms of Human Amyloid-Beta(1-42) Inhibit Antigen Presentation. Frontiers in Immunology. 11: 1029. PMID 32582162 DOI: 10.3389/Fimmu.2020.01029  0.343
2020 Rust R, Kirabali T, Grönnert L, Dogancay B, Limasale YDP, Meinhardt A, Werner C, Laviña B, Kulic L, Nitsch RM, Tackenberg C, Schwab ME. A Practical Guide to the Automated Analysis of Vascular Growth, Maturation and Injury in the Brain. Frontiers in Neuroscience. 14: 244. PMID 32265643 DOI: 10.3389/Fnins.2020.00244  0.748
2019 Kirabali T, Rigotti S, Siccoli A, Liebsch F, Shobo A, Hock C, Nitsch RM, Multhaup G, Kulic L. The amyloid-β degradation intermediate Aβ34 is pericyte-associated and reduced in brain capillaries of patients with Alzheimer's disease. Acta Neuropathologica Communications. 7: 194. PMID 31796114 DOI: 10.1186/s40478-019-0846-8  0.332
2019 Tackenberg C, Nitsch RM. The secreted APP ectodomain sAPPα, but not sAPPβ, protects neurons against Aβ oligomer-induced dendritic spine loss and increased tau phosphorylation. Molecular Brain. 12: 27. PMID 30922360 DOI: 10.1186/S13041-019-0447-2  0.804
2018 Birnbaum JH, Wanner D, Gietl AF, Saake A, Kündig TM, Hock C, Nitsch RM, Tackenberg C. Oxidative stress and altered mitochondrial protein expression in the absence of amyloid-β and tau pathology in iPSC-derived neurons from sporadic Alzheimer's disease patients. Stem Cell Research. 27: 121-130. PMID 29414602 DOI: 10.1016/J.Scr.2018.01.019  0.779
2018 Merlini M, Kirabali T, Kulic L, Nitsch RM, Ferretti MT. Extravascular CD3+ T Cells in Brains of Alzheimer Disease Patients Correlate with Tau but Not with Amyloid Pathology: An Immunohistochemical Study. Neuro-Degenerative Diseases. 18: 49-56. PMID 29402847 DOI: 10.1159/000486200  0.308
2016 Sevigny J, Chiao P, Bussière T, Weinreb PH, Williams L, Maier M, Dunstan R, Salloway S, Chen T, Ling Y, O'Gorman J, Qian F, Arastu M, Li M, Chollate S, ... ... Nitsch RM, et al. The antibody aducanumab reduces Aβ plaques in Alzheimer's disease. Nature. 537: 50-6. PMID 27582220 DOI: 10.1038/nature19323  0.315
2016 Merlini M, Wanner D, Nitsch RM. Tau pathology-dependent remodelling of cerebral arteries precedes Alzheimer's disease-related microvascular cerebral amyloid angiopathy. Acta Neuropathologica. PMID 26988843 DOI: 10.1007/S00401-016-1560-2  0.788
2016 Ferretti MT, Merlini M, Späni C, Gericke C, Schweizer N, Enzmann G, Engelhardt B, Kulic L, Suter T, Nitsch RM. T-cell brain infiltration and immature antigen-presenting cells in transgenic models of Alzheimer's disease-like cerebral amyloidosis. Brain, Behavior, and Immunity. PMID 26872418 DOI: 10.1016/J.Bbi.2016.02.009  0.312
2015 Hyman BT, Growdon JH, Albers MW, Buckner RL, Chhatwal J, Gomez-Isla MT, Haass C, Hudry E, Jack CR, Johnson KA, Khachaturian ZS, Kim DY, Martin JB, Nitsch RM, Rosen BR, et al. Massachusetts Alzheimer's Disease Research Center: Progress and challenges. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 26297855 DOI: 10.1016/J.Jalz.2015.06.1887  0.459
2015 Birnbaum JH, Bali J, Rajendran L, Nitsch RM, Tackenberg C. Calcium flux-independent NMDA receptor activity is required for Aβ oligomer-induced synaptic loss. Cell Death & Disease. 6: e1791. PMID 26086964 DOI: 10.1038/Cddis.2015.160  0.784
2013 Tackenberg C, Grinschgl S, Trutzel A, Santuccione AC, Frey MC, Konietzko U, Grimm J, Brandt R, Nitsch RM. NMDA receptor subunit composition determines beta-amyloid-induced neurodegeneration and synaptic loss. Cell Death & Disease. 4: e608. PMID 23618906 DOI: 10.1038/Cddis.2013.129  0.791
2013 Santuccione AC, Merlini M, Shetty A, Tackenberg C, Bali J, Ferretti MT, McAfoose J, Kulic L, Bernreuther C, Welt T, Grimm J, Glatzel M, Rajendran L, Hock C, Nitsch RM. Active vaccination with ankyrin G reduces β-amyloid pathology in APP transgenic mice. Molecular Psychiatry. 18: 358-68. PMID 22688190 DOI: 10.1038/Mp.2012.70  0.805
2012 Kulic L, McAfoose J, Welt T, Tackenberg C, Späni C, Wirth F, Finder V, Konietzko U, Giese M, Eckert A, Noriaki K, Shimizu T, Murakami K, Irie K, Rasool S, ... ... Nitsch RM, et al. Early accumulation of intracellular fibrillar oligomers and late congophilic amyloid angiopathy in mice expressing the Osaka intra-Aβ APP mutation. Translational Psychiatry. 2: e183. PMID 23149447 DOI: 10.1038/Tp.2012.109  0.785
2012 Biscaro B, Lindvall O, Tesco G, Ekdahl CT, Nitsch RM. Inhibition of microglial activation protects hippocampal neurogenesis and improves cognitive deficits in a transgenic mouse model for Alzheimer's disease. Neuro-Degenerative Diseases. 9: 187-98. PMID 22584394 DOI: 10.1159/000330363  0.33
2011 Merlini M, Meyer EP, Ulmann-Schuler A, Nitsch RM. Vascular β-amyloid and early astrocyte alterations impair cerebrovascular function and cerebral metabolism in transgenic arcAβ mice. Acta Neuropathologica. 122: 293-311. PMID 21688176 DOI: 10.1007/s00401-011-0834-y  0.303
2011 Cattepoel S, Hanenberg M, Kulic L, Nitsch RM. Chronic intranasal treatment with an anti-Aβ(30-42) scFv antibody ameliorates amyloid pathology in a transgenic mouse model of Alzheimer's disease. Plos One. 6: e18296. PMID 21483675 DOI: 10.1371/journal.pone.0018296  0.309
2010 Kocherhans S, Madhusudan A, Doehner J, Breu KS, Nitsch RM, Fritschy JM, Knuesel I. Reduced Reelin expression accelerates amyloid-beta plaque formation and tau pathology in transgenic Alzheimer's disease mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 9228-40. PMID 20610758 DOI: 10.1523/Jneurosci.0418-10.2010  0.301
2010 Serrano-Pozo A, William CM, Ferrer I, Uro-Coste E, Delisle MB, Maurage CA, Hock C, Nitsch RM, Masliah E, Growdon JH, Frosch MP, Hyman BT. Beneficial effect of human anti-amyloid-beta active immunization on neurite morphology and tau pathology. Brain : a Journal of Neurology. 133: 1312-27. PMID 20360050 DOI: 10.1093/Brain/Awq056  0.51
2006 Poirier R, Wolfer DP, Welzl H, Tracy J, Galsworthy MJ, Nitsch RM, Mohajeri MH. Neuronal neprilysin overexpression is associated with attenuation of Abeta-related spatial memory deficit. Neurobiology of Disease. 24: 475-83. PMID 17008108 DOI: 10.1016/j.nbd.2006.08.003  0.306
2006 Madani R, Poirier R, Wolfer DP, Welzl H, Groscurth P, Lipp HP, Lu B, El Mouedden M, Mercken M, Nitsch RM, Mohajeri MH. Lack of neprilysin suffices to generate murine amyloid-like deposits in the brain and behavioral deficit in vivo. Journal of Neuroscience Research. 84: 1871-8. PMID 16998901 DOI: 10.1002/Jnr.21074  0.329
2005 Papassotiropoulos A, Lambert JC, Wavrant-De Vrièze F, Wollmer MA, von der Kammer H, Streffer JR, Maddalena A, Huynh KD, Wolleb S, Lutjohann D, Schneider B, Thal DR, Grimaldi LM, Tsolaki M, Kapaki E, ... ... Nitsch RM, et al. Cholesterol 25-hydroxylase on chromosome 10q is a susceptibility gene for sporadic Alzheimer's disease. Neuro-Degenerative Diseases. 2: 233-41. PMID 16909003 DOI: 10.1159/000090362  0.311
2005 von Rotz RC, Kins S, Hipfel R, von der Kammer H, Nitsch RM. The novel cytosolic RING finger protein dactylidin is up-regulated in brains of patients with Alzheimer's disease. The European Journal of Neuroscience. 21: 1289-98. PMID 15813938 DOI: 10.1111/j.1460-9568.2005.03977.x  0.326
2004 Repetto E, Russo C, Venezia V, Nizzari M, Nitsch RM, Schettini G. BACE1 overexpression regulates amyloid precursor protein cleavage and interaction with the ShcA adapter. Annals of the New York Academy of Sciences. 1030: 330-8. PMID 15659814 DOI: 10.1196/Annals.1329.041  0.32
2004 Greeve I, Kretzschmar D, Tschäpe JA, Beyn A, Brellinger C, Schweizer M, Nitsch RM, Reifegerste R. Age-dependent neurodegeneration and Alzheimer-amyloid plaque formation in transgenic Drosophila. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 3899-906. PMID 15102905 DOI: 10.1523/Jneurosci.0283-04.2004  0.305
2004 Mohajeri MH, Kuehnle K, Li H, Poirier R, Tracy J, Nitsch RM. Anti-amyloid activity of neprilysin in plaque-bearing mouse models of Alzheimer's disease. Febs Letters. 562: 16-21. PMID 15043995 DOI: 10.1016/S0014-5793(04)00169-3  0.347
2003 Papassotiropoulos A, Streffer JR, Tsolaki M, Schmid S, Thal D, Nicosia F, Iakovidou V, Maddalena A, Lütjohann D, Ghebremedhin E, Hegi T, Pasch T, Träxler M, Brühl A, Benussi L, ... ... Nitsch RM, et al. Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with an intronic CYP46 polymorphism. Archives of Neurology. 60: 29-35. PMID 12533085 DOI: 10.1001/Archneur.60.1.29  0.313
2002 Mohajeri MH, Wollmer MA, Nitsch RM. Abeta 42-induced increase in neprilysin is associated with prevention of amyloid plaque formation in vivo. The Journal of Biological Chemistry. 277: 35460-5. PMID 12105192 DOI: 10.1074/jbc.M202899200  0.33
2001 Deng A, Irizarry MC, Nitsch RM, Growdon JH, Rebeck GW. Elevation of cystatin C in susceptible neurons in Alzheimer's disease. The American Journal of Pathology. 159: 1061-8. PMID 11549598 DOI: 10.1016/S0002-9440(10)61781-6  0.515
2001 Kins S, Crameri A, Evans DR, Hemmings BA, Nitsch RM, Gotz J. Reduced protein phosphatase 2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice. The Journal of Biological Chemistry. 276: 38193-200. PMID 11473109 DOI: 10.1074/jbc.M102621200  0.31
2001 von der Kammer H, Demiralay C, Andresen B, Albrecht C, Mayhaus M, Nitsch RM. Regulation of gene expression by muscarinic acetylcholine receptors. Biochemical Society Symposium. 131-40. PMID 11447829 DOI: 10.1042/Bst028A017  0.327
2000 Hock C, Maddalena A, Heuser I, Naber D, Oertel W, von der Kammer H, Wienrich M, Raschig A, Deng M, Growdon JH, Nitsch RM. Treatment with the selective muscarinic agonist talsaclidine decreases cerebrospinal fluid levels of total amyloid beta-peptide in patients with Alzheimer's disease. Annals of the New York Academy of Sciences. 920: 285-91. PMID 11193166 DOI: 10.1111/J.1749-6632.2000.Tb06937.X  0.518
2000 Nitsch RM, Deng M, Tennis M, Schoenfeld D, Growdon JH. The selective muscarinic M1 agonist AF102B decreases levels of total Abeta in cerebrospinal fluid of patients with Alzheimer's disease. Annals of Neurology. 48: 913-8. PMID 11117548 DOI: 10.1002/1531-8249(200012)48:6<913::Aid-Ana12>3.0.Co;2-S  0.543
2000 Finckh U, von der Kammer H, Velden J, Michel T, Andresen B, Deng A, Zhang J, Müller-Thomsen T, Zuchowski K, Menzer G, Mann U, Papassotiropoulos A, Heun R, Zurdel J, Holst F, ... ... Nitsch RM, et al. Genetic association of a cystatin C gene polymorphism with late-onset Alzheimer disease. Archives of Neurology. 57: 1579-83. PMID 11074789 DOI: 10.1001/Archneur.57.11.1579  0.49
2000 Greeve I, Hermans-Borgmeyer I, Brellinger C, Kasper D, Gomez-Isla T, Behl C, Levkau B, Nitsch RM. The human DIMINUTO/DWARF1 homolog seladin-1 confers resistance to Alzheimer's disease-associated neurodegeneration and oxidative stress. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 7345-52. PMID 11007892  0.323
2000 Albrecht C, von Der Kammer H, Mayhaus M, Klaudiny J, Schweizer M, Nitsch RM. Muscarinic acetylcholine receptors induce the expression of the immediate early growth regulatory gene CYR61. The Journal of Biological Chemistry. 275: 28929-36. PMID 10852911 DOI: 10.1074/jbc.M003053200  0.353
2000 Hock C, Heese K, Müller-Spahn F, Huber P, Riesen W, Nitsch RM, Otten U. Increased CSF levels of nerve growth factor in patients with Alzheimer's disease. Neurology. 54: 2009-11. PMID 10822447 DOI: 10.1212/Wnl.54.10.2009  0.342
2000 Growdon JH, Wurtman RJ, Corkin S, Nitsch RM. The molecular basis of dementia: Preface Annals of the New York Academy of Sciences. 920: xi-xii.  0.402
1999 Gasparini L, Ghidoni R, Alberici AC, Benussi L, Moratto D, Trabucchi M, Growdon JH, Nitsch RM, Binetti G. Modulation of presenilin-1 processing by nitric oxide during apoptosis induced by serum withdrawal and glucose deprivation. Annals of the New York Academy of Sciences. 893: 294-7. PMID 10672252 DOI: 10.1111/J.1749-6632.1999.Tb07840.X  0.461
1999 Alberici A, Moratto D, Benussi L, Gasparini L, Ghidoni R, Gatta LB, Finazzi D, Frisoni GB, Trabucchi M, Growdon JH, Nitsch RM, Binetti G. Presenilin 1 protein directly interacts with Bcl-2. The Journal of Biological Chemistry. 274: 30764-9. PMID 10521466 DOI: 10.1074/Jbc.274.43.30764  0.511
1998 Müller D, Nitsch RM, Wurtman RJ, Hoyer S. Streptozotocin increases free fatty acids and decreases phospholipids in rat brain. Journal of Neural Transmission (Vienna, Austria : 1996). 105: 1271-81. PMID 9928896 DOI: 10.1007/s007020050130  0.469
1998 Müller D, Wiegmann H, Langer U, Moltzen-Lenz S, Nitsch RM. Lu 25-109, a combined m1 agonist and m2 antagonist, modulates regulated processing of the amyloid precursor protein of Alzheimer's disease. Journal of Neural Transmission (Vienna, Austria : 1996). 105: 1029-43. PMID 9869334 DOI: 10.1007/s007020050110  0.387
1998 Liao A, Nitsch RM, Greenberg SM, Finckh U, Blacker D, Albert M, Rebeck GW, Gomez-Isla T, Clatworthy A, Binetti G, Hock C, Mueller-Thomsen T, Mann U, Zuchowski K, Beisiegel U, et al. Genetic association of an alpha2-macroglobulin (Val1000lle) polymorphism and Alzheimer's disease. Human Molecular Genetics. 7: 1953-6. PMID 9811940 DOI: 10.1093/Hmg/7.12.1953  0.561
1998 Nitsch RM, Rossner S, Albrecht C, Mayhaus M, Enderich J, Schliebs R, Wegner M, Arendt T, von der Kammer H. Muscarinic acetylcholine receptors activate the acetylcholinesterase gene promoter. Journal of Physiology, Paris. 92: 257-64. PMID 9789819 DOI: 10.1016/S0928-4257(98)80029-6  0.306
1998 Hock C, Drasch G, Golombowski S, Müller-Spahn F, Willershausen-Zönnchen B, Schwarz P, Hock U, Growdon JH, Nitsch RM. Increased blood mercury levels in patients with Alzheimer's disease. Journal of Neural Transmission (Vienna, Austria : 1996). 105: 59-68. PMID 9588761 DOI: 10.1007/s007020050038  0.567
1998 Nitsch RM, Kim C, Growdon JH. Vasopressin and bradykinin regulate secretory processing of the amyloid protein precursor of Alzheimer's disease. Neurochemical Research. 23: 807-14. PMID 9566621 DOI: 10.1023/A:1022423813362  0.598
1998 Hock C, Golombowski S, Müller-Spahn F, Naser W, Beyreuther K, Mönning U, Schenk D, Vigo-Pelfrey C, Bush AM, Moir R, Tanzi RE, Growdon JH, Nitsch RM. Cerebrospinal fluid levels of amyloid precursor protein and amyloid beta-peptide in Alzheimer's disease and major depression - inverse correlation with dementia severity. European Neurology. 39: 111-8. PMID 9520072 DOI: 10.1159/000007917  0.53
1997 Nitsch RM, Deng A, Wurtman RJ, Growdon JH. Metabotropic glutamate receptor subtype mGluR1alpha stimulates the secretion of the amyloid beta-protein precursor ectodomain. Journal of Neurochemistry. 69: 704-12. PMID 9231730 DOI: 10.1046/j.1471-4159.1997.69020704.x  0.633
1997 Müller DM, Mendla K, Farber SA, Nitsch RM. Muscarinic M1 receptor agonists increase the secretion of the amyloid precursor protein ectodomain. Life Sciences. 60: 985-91. PMID 9121365 DOI: 10.1016/S0024-3205(97)00038-6  0.671
1996 Nitsch RM. From acetylcholine to amyloid: neurotransmitters and the pathology of Alzheimer's disease. Neurodegeneration : a Journal For Neurodegenerative Disorders, Neuroprotection, and Neuroregeneration. 5: 477-82. PMID 9117566 DOI: 10.1006/neur.1996.0066  0.437
1996 Nitsch RM, Deng M, Growdon JH, Wurtman RJ. Serotonin 5-HT2a and 5-HT2c receptors stimulate amyloid precursor protein ectodomain secretion. The Journal of Biological Chemistry. 271: 4188-94. PMID 8626761 DOI: 10.1074/jbc.271.8.4188  0.66
1996 Nitsch RM, Wurtman RJ, Growdon JH. Regulation of APP processing. Potential for the therapeutical reduction of brain amyloid burden. Annals of the New York Academy of Sciences. 777: 175-82. PMID 8624081 DOI: 10.1111/j.1749-6632.1996.tb34416.x  0.683
1995 Nitsch RM, Wurtman RJ, Growdon JH. Regulation of proteolytic processing of the amyloid beta-protein precursor by first messengers. A novel potential approach for the treatment of Alzheimer's disease. Arzneimittel-Forschung. 45: 435-8. PMID 7763340  0.549
1995 Nitsch RM, Rebeck GW, Deng M, Richardson UI, Tennis M, Schenk DB, Vigo-Pelfrey C, Lieberburg I, Wurtman RJ, Hyman BT. Cerebrospinal fluid levels of amyloid beta-protein in Alzheimer's disease: inverse correlation with severity of dementia and effect of apolipoprotein E genotype. Annals of Neurology. 37: 512-8. PMID 7717688 DOI: 10.1002/Ana.410370414  0.56
1995 Lee RK, Wurtman RJ, Cox AJ, Nitsch RM. Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors. Proceedings of the National Academy of Sciences of the United States of America. 92: 8083-7. PMID 7644542 DOI: 10.1073/pnas.92.17.8083  0.491
1995 Farber SA, Nitsch RM, Schulz JG, Wurtman RJ. Regulated secretion of beta-amyloid precursor protein in rat brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 7442-51. PMID 7472496  0.697
1995 Nitsch RM, Marinescu V, Postle BR, Corkin S, Wurtman RJ. Eight Meeting of the International Study Group on the Pharmacology of Memory Disorders Associated with Aging. The Neurobiology of Alzheimer's Disease, Zurich, Switzerland, February 17-19, 1995 Amyloid. 2: 204-212. DOI: 10.3109/13506129509036928  0.37
1995 Farber S, Nitsch R, Schulz J, Wurtman R. Regulated secretion of beta-amyloid precursor protein in rat brain The Journal of Neuroscience. 15: 7442-7451. DOI: 10.1523/JNEUROSCI.15-11-07442.1995  0.751
1994 Nitsch RM, Growdon JH. Role of neurotransmission in the regulation of amyloid beta-protein precursor processing. Biochemical Pharmacology. 47: 1275-84. PMID 7910457 DOI: 10.1016/0006-2952(94)90325-5  0.529
1994 Nitsch RM, Slack BE, Farber SA, Schulz JG, Deng M, Kim C, Borghesani PR, Korver W, Wurtman RJ, Growdon JH. Regulation of proteolytic processing of the amyloid beta-protein precursor of Alzheimer's disease in transfected cell lines and in brain slices. Journal of Neural Transmission. Supplementum. 44: 21-7. PMID 7897393 DOI: 10.1007/978-3-7091-9350-1_2  0.807
1994 Farber S, Nitsch R, Growdon J, Wurtman R. 24. A novel approach to study the regulated release of secretory proteins from brain slices Journal of Neuroscience Methods. 52: A11-A12. DOI: 10.1016/0165-0270(94)90084-1  0.715
1993 Nitsch RM, Farber SA, Growdon JH, Wurtman RJ. Release of amyloid beta-protein precursor derivatives by electrical depolarization of rat hippocampal slices. Proceedings of the National Academy of Sciences of the United States of America. 90: 5191-3. PMID 8506366 DOI: 10.1073/PNAS.90.11.5191  0.748
1993 Slack BE, Nitsch RM, Livneh E, Kunz GM, Breu J, Eldar H, Wurtman RJ. Regulation by phorbol esters of amyloid precursor protein release from Swiss 3T3 fibroblasts overexpressing protein kinase C alpha. The Journal of Biological Chemistry. 268: 21097-101. PMID 8407946  0.585
1993 Nitsch RM, Blusztajn JK, Doyle FM, Robitaille Y, Wurtman RJ, Growdon JH, Kish SJ. Phospholipid metabolite levels are altered in cerebral cortex of patients with dominantly inherited olivopontocerebellar atrophy. Neuroscience Letters. 161: 191-4. PMID 8272265 DOI: 10.1016/0304-3940(93)90291-R  0.604
1993 Holmes TC, Nitsch RM, Erfurth A, Wurtman RJ. Phospholipid and phospholipid metabolites in rat frontal cortex are decreased following nucleus basalis lesions. Annals of the New York Academy of Sciences. 695: 241-3. PMID 8239290 DOI: 10.1111/j.1749-6632.1993.tb23060.x  0.707
1993 Slack BE, Nitsch RM, Livneh E, Kunz GM, Eldar H, Wurtman RJ. Regulation of amyloid precursor protein release by protein kinase C in Swiss 3T3 fibroblasts. Annals of the New York Academy of Sciences. 695: 128-31. PMID 8239270 DOI: 10.1111/j.1749-6632.1993.tb23040.x  0.689
1993 Nitsch RM, Slack BE, Farber SA, Borghesani PR, Schulz JG, Kim C, Felder CC, Growdon JH, Wurtman RJ. Receptor-coupled amyloid precursor protein processing. Annals of the New York Academy of Sciences. 695: 122-7. PMID 8239269 DOI: 10.1111/J.1749-6632.1993.Tb23039.X  0.801
1993 Hung AY, Haass C, Nitsch RM, Qiu WQ, Citron M, Wurtman RJ, Growdon JH, Selkoe DJ. Activation of protein kinase C inhibits cellular production of the amyloid beta-protein. The Journal of Biological Chemistry. 268: 22959-62. PMID 8226807  0.51
1992 Slack BE, Richardson UI, Nitsch RM, Wurtman RJ. Dioctanoylglycerol stimulates accumulation of [methyl-14C]choline and its incorporation into acetylcholine and phosphatidylcholine in a human cholinergic neuroblastoma cell line. Brain Research. 585: 169-76. PMID 1511298 DOI: 10.1016/0006-8993(92)91203-Q  0.642
1992 Nitsch RM, Slack BE, Wurtman RJ, Growdon JH. Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors. Science (New York, N.Y.). 258: 304-7. PMID 1411529 DOI: 10.1126/SCIENCE.1411529  0.754
1992 Nitsch RM, Blusztajn JK, Pittas AG, Slack BE, Growdon JH, Wurtman RJ. Evidence for a membrane defect in Alzheimer disease brain. Proceedings of the National Academy of Sciences of the United States of America. 89: 1671-5. PMID 1311847 DOI: 10.1073/Pnas.89.5.1671  0.744
1992 Nitsch RM, Slack BE, Wurtman RJ, Growdon JH. SECRETION OF ALZHEIMER AMYLOID PRECURSOR PROTEIN IS STIMULATED BY MUSCARINIC RECEPTOR ACTIVATION. Clinical Neuropharmacology. 15: 464B. DOI: 10.1097/00002826-199202001-00902  0.609
1991 Nitsch R, Pittas A, Blusztajn JK, Slack BE, Growdon JH, Wurtman RJ. Alterations of phospholipid metabolites in postmortem brain from patients with Alzheimer's disease. Annals of the New York Academy of Sciences. 640: 110-3. PMID 1663712 DOI: 10.1111/J.1749-6632.1991.Tb00200.X  0.758
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