Roger M. Nitsch, MD - Related publications

Affiliations: 
Psychiatry Universität Zürich, Zürich, ZH, Switzerland 
Area:
Alzheimer’s disease, genetics
Website:
http://www.dpr.uzh.ch/aboutus/People/directors/nitsch.html
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50 most relevant papers in past 60 days:
Year Citation  Score
2020 Robakis NK. What Do Recent Clinical Trials Teach Us About the Etiology of AD. Advances in Experimental Medicine and Biology. 1195: 167. PMID 32468473 DOI: 10.1007/978-3-030-32633-3_23   
2020 Gericke C, Mallone A, Engelhardt B, Nitsch RM, Ferretti MT. Oligomeric Forms of Human Amyloid-Beta(1-42) Inhibit Antigen Presentation. Frontiers in Immunology. 11: 1029. PMID 32582162 DOI: 10.3389/fimmu.2020.01029   
2020 Liang Y, Raven F, Ward JF, Zhen S, Zhang S, Sun H, Miller SJ, Choi SH, Tanzi RE, Zhang C. Upregulation of Alzheimer's Disease Amyloid-β Protein Precursor in Astrocytes Both in vitro and in vivo. Journal of Alzheimer's Disease : Jad. PMID 32597805 DOI: 10.3233/JAD-200128   
2020 Park SY, Kang JY, Lee T, Nam D, Jeon CJ, Kim JB. Can Reduce Amyloid Beta and Reverse Cognitive Impairment and Memory Dysfunction in Alzheimer's Disease Mouse Model. Cells. 9. PMID 32455709 DOI: 10.3390/cells9051275   
2020 Mamun AA, Uddin MS, Bin Bashar MF, Zaman S, Begum Y, Bulbul IJ, Islam MS, Sarwar MS, Mathew B, Amran MS, Md Ashraf G, Bin-Jumah MN, Mousa SA, Abdel-Daim MM. Molecular Insight into the Therapeutic Promise of Targeting for Alzheimer's Disease. Oxidative Medicine and Cellular Longevity. 2020: 5086250. PMID 32509144 DOI: 10.1155/2020/5086250   
2020 Pérez-González M, Mendioroz M, Badesso S, Sucunza D, Roldan M, Espelosín M, Ursua S, Luján R, Cuadrado-Tejedor M, Garcia-Osta A. PLA2G4E, a candidate gene for resilience in Alzheimer´s disease and a new target for dementia treatment. Progress in Neurobiology. 101818. PMID 32380223 DOI: 10.1016/j.pneurobio.2020.101818   
2020 Mei X, Zhu L, Zhou Q, Li X, Chen Z. Interplay of curcumin and its liver metabolism on the level of Aβ in the brain of APP/PS1 mice before AD onset. Pharmacological Reports : Pr. PMID 32468514 DOI: 10.1007/s43440-020-00116-z   
2020 Shah H, Patel A, Parikh V, Nagani A, Bhimani B, Shah U, Bambharoliya T. The β-secretase enzyme BACE1: A biochemical enigma for Alzheimer's disease. Cns & Neurological Disorders Drug Targets. PMID 32452328 DOI: 10.2174/1871527319666200526144141   
2020 Eke CS, Jammeh E, Li X, Carroll C, Pearson S, Ifeachor E. Early Detection of Alzheimer's Disease with Blood Plasma Proteins using Support Vector Machines. Ieee Journal of Biomedical and Health Informatics. PMID 32340968 DOI: 10.1109/JBHI.2020.2984355   
2020 Cairns DM, Rouleau N, Parker RN, Walsh KG, Gehrke L, Kaplan DL. A 3D human brain-like tissue model of herpes-induced Alzheimer's disease. Science Advances. 6: eaay8828. PMID 32494701 DOI: 10.1126/sciadv.aay8828   
2020 Yuan C, Aierken A, Xie Z, Li N, Zhao J, Qing H. The age-related microglial transformation in Alzheimer's disease pathogenesis. Neurobiology of Aging. 92: 82-91. PMID 32408056 DOI: 10.1016/j.neurobiolaging.2020.03.024   
2020 Chen M, Xia W. Proteomic Profiling of Plasma and Brain Tissue from Alzheimer's Disease Patients Reveals Candidate Network of Plasma Biomarkers. Journal of Alzheimer's Disease : Jad. PMID 32474469 DOI: 10.3233/JAD-200110   
2020 Harris SS, Wolf F, De Strooper B, Busche MA. Tipping the Scales: Peptide-Dependent Dysregulation of Neural Circuit Dynamics in Alzheimer's Disease. Neuron. PMID 32579881 DOI: 10.1016/j.neuron.2020.06.005   
2020 Konijnenberg E, Tijms BM, Gobom J, Dobricic V, Bos I, Vos S, Tsolaki M, Verhey F, Popp J, Martinez-Lage P, Vandenberghe R, Lleó A, Frölich L, Lovestone S, Streffer J, et al. APOE ε4 genotype-dependent cerebrospinal fluid proteomic signatures in Alzheimer's disease. Alzheimer's Research & Therapy. 12: 65. PMID 32460813 DOI: 10.1186/s13195-020-00628-z   
2020 Uddin MS, Kabir MT, Al Mamun A, Behl T, Mansouri RA, Aloqbi AA, Perveen A, Hafeez A, Ashraf GM. Exploring Potential of Alkaloidal Phytochemicals Targeting Neuroinflammatory Signaling of Alzheimer's Disease. Current Pharmaceutical Design. PMID 32473620 DOI: 10.2174/1381612826666200531151004   
2020 Amponsah AE, Feng B, Guo R, Zhang W, He J, Kong D, Dong T, Ma J, Cui H. Fragmentation of brain apolipoprotein E (ApoE) and its relevance in Alzheimer's disease. Reviews in the Neurosciences. PMID 32364519 DOI: 10.1515/revneuro-2019-0115   
2020 Stefanescu R, Stanciu GD, Luca A, Paduraru L, Tamba BI. Secondary Metabolites from Plants Possessing Inhibitory Properties against Beta-Amyloid Aggregation as Revealed by Thioflavin-T Assay and Correlations with Investigations on Transgenic Mouse Models of Alzheimer's Disease. Biomolecules. 10. PMID 32517180 DOI: 10.3390/biom10060870   
2020 Qin T, Prins S, Groeneveld GJ, Van Westen G, de Vries HE, Wong YC, Bischoff LJM, de Lange ECM. Utility of Animal Models to Understand Human Alzheimer's Disease, Using the Mastermind Research Approach to Avoid Unnecessary Further Sacrifices of Animals. International Journal of Molecular Sciences. 21. PMID 32365768 DOI: 10.3390/ijms21093158   
2020 Singh M, Singh SP, Dubey PK, Rachana R, Mani S, Yadav D, Agarwal M, Agarwal S, Agarwal V, Kaur H. Advent of Proteomic Tools For Diagnostic Biomarker Analysis in Alzheimer's Disease. Current Protein & Peptide Science. PMID 32538723 DOI: 10.2174/1389203721666200615173213   
2020 Abrahamson EE, Stehouwer JS, Vazquez AL, Huang GF, Mason NS, Lopresti BJ, Klunk WE, Mathis CA, Ikonomovic MD. Development of a PET radioligand selective for cerebral amyloid angiopathy. Nuclear Medicine and Biology. PMID 32471773 DOI: 10.1016/j.nucmedbio.2020.05.001   
2020 Novak G, Streffer JR, Timmers M, Henley D, Brashear HR, Bogert J, Russu A, Janssens L, Tesseur I, Tritsmans L, Van Nueten L, Engelborghs S. Long-term safety and tolerability of atabecestat (JNJ-54861911), an oral BACE1 inhibitor, in early Alzheimer's disease spectrum patients: a randomized, double-blind, placebo-controlled study and a two-period extension study. Alzheimer's Research & Therapy. 12: 58. PMID 32410694 DOI: 10.1186/s13195-020-00614-5   
2020 Chen Y, Fang L, Chen S, Zhou H, Fan Y, Lin L, Li J, Xu J, Chen Y, Ma Y, Chen Y. Gut Microbiome Alterations Precede Cerebral Amyloidosis and Microglial Pathology in a Mouse Model of Alzheimer's Disease. Biomed Research International. 2020: 8456596. PMID 32596386 DOI: 10.1155/2020/8456596   
2020 Uddin MS, Kabir MT, Mamun AA, Barreto GE, Rashid M, Perveen A, Ashraf GM. Pharmacological approaches to mitigate neuroinflammation in Alzheimer's disease. International Immunopharmacology. 84: 106479. PMID 32353686 DOI: 10.1016/j.intimp.2020.106479   
2020 Jang JW, Kim Y, Kim S, Park SW, Kwon SO, Park YH, Lim JS, Youn YC, Hun Kim S, Kim S, . Dynamic association between AT(N) profile and cognition mediated by cortical thickness in Alzheimer's continuum. Neuroimage. Clinical. 27: 102282. PMID 32590333 DOI: 10.1016/j.nicl.2020.102282   
2020 Schnöder L, Gasparoni G, Nordström K, Schottek A, Tomic I, Christmann A, Schäfer KH, Menger MD, Walter J, Fassbender K, Liu Y. Neuronal deficiency of p38α-MAPK ameliorates symptoms and pathology of APP or Tau-transgenic Alzheimer's mouse models. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32475008 DOI: 10.1096/fj.201902731RR   
2020 Yang J, Wise L, Fukuchi KI. TLR4 Cross-Talk With NLRP3 Inflammasome and Complement Signaling Pathways in Alzheimer's Disease. Frontiers in Immunology. 11: 724. PMID 32391019 DOI: 10.3389/fimmu.2020.00724   
2020 Vasanthakumar A, Davis JW, Idler K, Waring JF, Asque E, Riley-Gillis B, Grosskurth S, Srivastava G, Kim S, Nho K, Nudelman KNH, Faber K, Sun Y, Foroud TM, Estrada K, ... , et al. Harnessing peripheral DNA methylation differences in the Alzheimer's Disease Neuroimaging Initiative (ADNI) to reveal novel biomarkers of disease. Clinical Epigenetics. 12: 84. PMID 32539856 DOI: 10.1186/s13148-020-00864-y   
2020 Kou X, Chen D, Chen N. The Regulation of microRNAs in Alzheimer's Disease. Frontiers in Neurology. 11: 288. PMID 32362867 DOI: 10.3389/fneur.2020.00288   
2020 Crooks EJ, Irizarry BA, Ziliox M, Kawakami T, Victor TW, Xu F, Hojo H, Chiu K, Simmerling C, Van Nostrand WE, Smith SO, Miller LM. Copper stabilizes antiparallel β-sheet fibrils of the amyloid β40 (Aβ40)-Iowa variant. The Journal of Biological Chemistry. PMID 32376688 DOI: 10.1074/jbc.RA119.011955   
2020 Wang L, Zhou Y, Chen D, Lee TH. Peptidyl-Prolyl Isomerase Pin1 and Alzheimer's Disease. Frontiers in Cell and Developmental Biology. 8: 355. PMID 32500074 DOI: 10.3389/fcell.2020.00355   
2020 Shi Z, Fu LP, Zhang N, Zhao X, Liu S, Zuo C, Cai L, Wang Y, Gao S, Ai L, Guan Y, Xu B, Ji Y. Amyloid PET in Dementia Syndromes: A Chinese Multicenter Study. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 32385166 DOI: 10.2967/jnumed.119.240325   
2020 Rafii MS. Alzheimer's Disease in Down Syndrome: Progress in the Design and Conduct of Drug Prevention Trials. Cns Drugs. PMID 32506291 DOI: 10.1007/s40263-020-00740-6   
2020 Ferreira S, Pitman KA, Wang S, Summers BS, Bye N, Young KM, Cullen CL. Amyloidosis is associated with thicker myelin and increased oligodendrogenesis in the adult mouse brain. Journal of Neuroscience Research. PMID 32557778 DOI: 10.1002/jnr.24672   
2020 Ren P, Chen J, Li B, Zhang M, Yang B, Guo X, Chen Z, Cheng H, Wang P, Wang S, Wang N, Zhang G, Wu X, Ma D, Guan D, et al. Nrf2 Ablation Promotes Alzheimer's Disease-Like Pathology in APP/PS1 Transgenic Mice: The Role of Neuroinflammation and Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2020: 3050971. PMID 32454936 DOI: 10.1155/2020/3050971   
2020 Kaeser GE, Chun J. Mosaic Somatic Gene Recombination as a Potentially Unifying Hypothesis for Alzheimer's Disease. Frontiers in Genetics. 11: 390. PMID 32457796 DOI: 10.3389/fgene.2020.00390   
2020 Khalaf NEA, El Banna FM, Youssef MY, Mosaad YM, Daba MY, Ashour RH. Clopidogrel combats neuroinflammation and enhances learning behavior and memory in a rat model of Alzheimer's disease. Pharmacology, Biochemistry, and Behavior. 172956. PMID 32474163 DOI: 10.1016/j.pbb.2020.172956   
2020 Yang Y, Zhang Z. Microglia and Wnt Pathways: Prospects for Inflammation in Alzheimer's Disease. Frontiers in Aging Neuroscience. 12: 110. PMID 32477095 DOI: 10.3389/fnagi.2020.00110   
2020 Kang MS, Aliaga AA, Shin M, Mathotaarachchi S, Benedet AL, Pascoal TA, Therriault J, Chamoun M, Savard M, Devenyi GA, Mathieu A, Chakravarty MM, Sandelius Å, Blennow K, Zetterberg H, ... , et al. Amyloid-beta modulates the association between neurofilament light chain and brain atrophy in Alzheimer's disease. Molecular Psychiatry. PMID 32591633 DOI: 10.1038/s41380-020-0818-1   
2020 Aisen PS, Cummings J, Doody R, Kramer L, Salloway S, Selkoe DJ, Sims J, Sperling RA, Vellas B. The Future of Anti-Amyloid Trials. The Journal of Prevention of Alzheimer's Disease. 7: 146-151. PMID 32463066 DOI: 10.14283/jpad.2020.24   
2020 Li KY, Gong PF, Li JT, Xu NJ, Qin S. Morphological and molecular alterations of reactive astrocytes without proliferation in cerebral cortex of an APP/PS1 transgenic mouse model and Alzheimer's patients. Glia. PMID 32469469 DOI: 10.1002/glia.23845   
2020 Yang WD, Dong WG. [Mechanisms of electroacupuncture for improving Alzheimer's disease from reducing β amyloid protein level]. Zhen Ci Yan Jiu = Acupuncture Research. 45: 426-31. PMID 32447861 DOI: 10.13702/j.1000-0607.180885   
2020 Fülöp T, Munawara U, Larbi A, Desroches M, Rodrigues S, Catanzaro M, Guidolin A, Khalil A, Bernier F, Barron AE, Hirokawa K, Beauregard PB, Dumoulin D, Bellenger JP, Witkowski JM, et al. Targeting Infectious Agents as a Therapeutic Strategy in Alzheimer's Disease. Cns Drugs. PMID 32458360 DOI: 10.1007/s40263-020-00737-1   
2020 Chae CW, Lee HJ, Choi GE, Jung YH, Kim JS, Lim JR, Kim SY, Hwang IK, Seong JK, Han HJ. High glucose-mediated PICALM and mTORC1 modulate processing of amyloid precursor protein via endosomal abnormalities. British Journal of Pharmacology. PMID 32436237 DOI: 10.1111/bph.15131   
2020 Bhute S, Sarmah D, Datta A, Rane P, Shard A, Goswami A, Borah A, Kalia K, Dave KR, Bhattacharya P. Molecular Pathogenesis and Interventional Strategies for Alzheimer's Disease: Promises and Pitfalls. Acs Pharmacology & Translational Science. 3: 472-488. PMID 32566913 DOI: 10.1021/acsptsci.9b00104   
2020 Jia L, Wang W, Yan Y, Hu R, Sang J, Zhao W, Wang Y, Wei W, Cui W, Yang G, Lu F, Zheng J, Liu F. General Aggregation-Induced Emission Probes for Amyloid Inhibitors with Dual Inhibition Capacity against Amyloid β-Protein and α-Synuclein. Acs Applied Materials & Interfaces. PMID 32584021 DOI: 10.1021/acsami.0c07745   
2020 Kim JW, Byun MS, Yi D, Lee JH, Jeon SY, Ko K, Jung G, Lee HN, Lee JY, Sohn CH, Lee YS, Shin SA, Kim YK, Lee DY, . Serum Uric Acid, Alzheimer-Related Brain Changes, and Cognitive Impairment. Frontiers in Aging Neuroscience. 12: 160. PMID 32581770 DOI: 10.3389/fnagi.2020.00160   
2020 Schedin-Weiss S, Nilsson P, Sandebring-Matton A, Axenhus M, Sekiguchi M, Saito T, Winblad B, Saido T, Tjernberg LO. Proteomics Time-Course Study of App Knock-In Mice Reveals Novel Presymptomatic Aβ42-Induced Pathways to Alzheimer's Disease Pathology. Journal of Alzheimer's Disease : Jad. PMID 32280097 DOI: 10.3233/JAD-200028   
2020 Kloske CM, Wilcock DM. The Important Interface Between Apolipoprotein E and Neuroinflammation in Alzheimer's Disease. Frontiers in Immunology. 11: 754. PMID 32425941 DOI: 10.3389/fimmu.2020.00754   
2020 Puzzo D, Argyrousi EK, Staniszewski A, Zhang H, Calcagno E, Zuccarello E, Acquarone E, Fà M, Li Puma DD, Grassi C, D'Adamio L, Kanaan NM, Fraser PE, Arancio O. Tau is not necessary for amyloid-beta-induced synaptic and memory impairments. The Journal of Clinical Investigation. PMID 32544084 DOI: 10.1172/JCI137040   
2020 Cole MA, Seabrook GR. On the horizon-the value and promise of the global pipeline of Alzheimer's disease therapeutics. Alzheimer's & Dementia (New York, N. Y.). 6: e12009. PMID 32405530 DOI: 10.1002/trc2.12009