Shaun Coughlin - Publications

University of California, San Francisco, San Francisco, CA 

108 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Gazit SL, Mariko B, Thérond P, Decouture B, Xiong Y, Couty L, Bonnin P, Baudrie V, Le Gall SM, Dizier B, Zoghdani N, Ransinan J, Hamilton JR, Gaussem P, Tharaux PL, ... ... Coughlin SR, et al. Platelet and Erythrocyte Sources of S1P Are Redundant for Vascular Development and Homeostasis, but both Rendered Essential After Plasma S1P Depletion in Anaphylactic Shock. Circulation Research. PMID 27582371 DOI: 10.1161/CIRCRESAHA.116.308929  0.44
2016 David T, Kim YC, Ely LK, Rondon I, Gao H, O'Brien P, Bolt MW, Coyle AJ, Garcia JL, Flounders EA, Mikita T, Coughlin SR. Factor XIa-specific IgG and a reversal agent to probe factor XI function in thrombosis and hemostasis. Science Translational Medicine. 8: 353ra112. PMID 27559095 DOI: 10.1126/scitranslmed.aaf4331  0.44
2015 Pfreundschuh M, Alsteens D, Wieneke R, Zhang C, Coughlin SR, Tampé R, Kobilka BK, Müller DJ. Identifying and quantifying two ligand-binding sites while imaging native human membrane receptors by AFM. Nature Communications. 6: 8857. PMID 26561004 DOI: 10.1038/ncomms9857  0.44
2015 Page MJ, Lourenço AL, David T, LeBeau AM, Cattaruzza F, Castro HC, VanBrocklin HF, Coughlin SR, Craik CS. Non-invasive imaging and cellular tracking of pulmonary emboli by near-infrared fluorescence and positron-emission tomography. Nature Communications. 6: 8448. PMID 26423607 DOI: 10.1038/ncomms9448  0.44
2015 Prasad JM, Gorkun OV, Raghu H, Thornton S, Mullins ES, Palumbo JS, Ko YP, Höök M, David T, Coughlin SR, Degen JL, Flick MJ. Mice expressing a mutant form of fibrinogen that cannot support fibrin formation exhibit compromised antimicrobial host defense. Blood. PMID 26228483 DOI: 10.1182/blood-2015-04-639849  0.44
2015 Wilsbacher LD, Coughlin SR. Analysis of cardiomyocyte development using immunofluorescence in embryonic mouse heart. Journal of Visualized Experiments : Jove. PMID 25866997 DOI: 10.3791/52644  0.44
2015 Clay H, Coughlin SR. Mechanical vessel injury in zebrafish embryos. Journal of Visualized Experiments : Jove. e52460. PMID 25742284 DOI: 10.3791/52460  0.44
2015 Berger M, Scheel DW, Macias H, Miyatsuka T, Kim H, Hoang P, Ku GM, Honig G, Liou A, Tang Y, Regard JB, Sharifnia P, Yu L, Wang J, Coughlin SR, et al. Gαi/o-coupled receptor signaling restricts pancreatic β-cell expansion. Proceedings of the National Academy of Sciences of the United States of America. 112: 2888-93. PMID 25695968 DOI: 10.1073/pnas.1319378112  0.44
2015 Alsteens D, Pfreundschuh M, Zhang C, Spoerri PM, Coughlin SR, Kobilka BK, Müller DJ. Imaging G protein-coupled receptors while quantifying their ligand-binding free-energy landscape Nature Methods. 12: 845-851. DOI: 10.1038/nmeth.3479  0.44
2014 Edelstein LC, Simon LM, Lindsay CR, Kong X, Teruel-Montoya R, Tourdot BE, Chen ES, Ma L, Coughlin S, Nieman M, Holinstat M, Shaw CA, Bray PF. Common variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by race. Blood. 124: 3450-8. PMID 25293779 DOI: 10.1182/blood-2014-04-572479  0.44
2014 Bynagari-Settipalli YS, Cornelissen I, Palmer D, Duong D, Concengco C, Ware J, Coughlin SR. Redundancy and interaction of thrombin- and collagen-mediated platelet activation in tail bleeding and carotid thrombosis in mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 34: 2563-9. PMID 25278288 DOI: 10.1161/ATVBAHA.114.304244  0.44
2013 Herzog BH, Fu J, Wilson SJ, Hess PR, Sen A, McDaniel JM, Pan Y, Sheng M, Yago T, Silasi-Mansat R, McGee S, May F, Nieswandt B, Morris AJ, Lupu F, ... Coughlin SR, et al. Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. Nature. 502: 105-9. PMID 23995678 DOI: 10.1038/nature12501  0.44
2013 Miller CN, Hartigan-O'Connor DJ, Lee MS, Laidlaw G, Cornelissen IP, Matloubian M, Coughlin SR, McDonald DM, McCune JM. IL-7 production in murine lymphatic endothelial cells and induction in the setting of peripheral lymphopenia. International Immunology. 25: 471-83. PMID 23657000 DOI: 10.1093/intimm/dxt012  0.44
2013 Khoufache K, Berri F, Nacken W, Vogel AB, Delenne M, Camerer E, Coughlin SR, Carmeliet P, Lina B, Rimmelzwaan GF, Planz O, Ludwig S, Riteau B. PAR1 contributes to influenza A virus pathogenicity in mice. The Journal of Clinical Investigation. 123: 206-14. PMID 23202729 DOI: 10.1172/JCI61667  0.44
2012 Zhang C, Srinivasan Y, Arlow DH, Fung JJ, Palmer D, Zheng Y, Green HF, Pandey A, Dror RO, Shaw DE, Weis WI, Coughlin SR, Kobilka BK. High-resolution crystal structure of human protease-activated receptor 1. Nature. 492: 387-92. PMID 23222541 DOI: 10.1038/nature11701  0.44
2012 Yang H, Kim A, David T, Palmer D, Jin T, Tien J, Huang F, Cheng T, Coughlin SR, Jan YN, Jan LY. TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation. Cell. 151: 111-22. PMID 23021219 DOI: 10.1016/j.cell.2012.07.036  0.44
2011 Regard JB, Cherman N, Palmer D, Kuznetsov SA, Celi FS, Guettier JM, Chen M, Bhattacharyya N, Wess J, Coughlin SR, Weinstein LS, Collins MT, Robey PG, Yang Y. Wnt/β-catenin signaling is differentially regulated by Gα proteins and contributes to fibrous dysplasia. Proceedings of the National Academy of Sciences of the United States of America. 108: 20101-6. PMID 22106277 DOI: 10.1073/pnas.1114656108  0.44
2011 Arnon TI, Xu Y, Lo C, Pham T, An J, Coughlin S, Dorn GW, Cyster JG. GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood. Science (New York, N.Y.). 333: 1898-903. PMID 21960637 DOI: 10.1126/science.1208248  0.44
2011 Shao B, Wahrenbrock MG, Yao L, David T, Coughlin SR, Xia L, Varki A, McEver RP. Carcinoma mucins trigger reciprocal activation of platelets and neutrophils in a murine model of Trousseau syndrome. Blood. 118: 4015-23. PMID 21860019 DOI: 10.1182/blood-2011-07-368514  0.44
2011 Green JA, Suzuki K, Cho B, Willison LD, Palmer D, Allen CD, Schmidt TH, Xu Y, Proia RL, Coughlin SR, Cyster JG. The sphingosine 1-phosphate receptor S1Pâ‚‚ maintains the homeostasis of germinal center B cells and promotes niche confinement. Nature Immunology. 12: 672-80. PMID 21642988 DOI: 10.1038/ni.2047  0.44
2011 Frateschi S, Camerer E, Crisante G, Rieser S, Membrez M, Charles RP, Beermann F, Stehle JC, Breiden B, Sandhoff K, Rotman S, Haftek M, Wilson A, Ryser S, Steinhoff M, ... Coughlin SR, et al. PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin. Nature Communications. 2: 161. PMID 21245842 DOI: 10.1038/ncomms1162  0.44
2010 Cornelissen I, Palmer D, David T, Wilsbacher L, Concengco C, Conley P, Pandey A, Coughlin SR. Roles and interactions among protease-activated receptors and P2ry12 in hemostasis and thrombosis. Proceedings of the National Academy of Sciences of the United States of America. 107: 18605-10. PMID 20930120 DOI: 10.1073/pnas.1013309107  0.44
2010 Camerer E, Barker A, Duong DN, Ganesan R, Kataoka H, Cornelissen I, Darragh MR, Hussain A, Zheng YW, Srinivasan Y, Brown C, Xu SM, Regard JB, Lin CY, Craik CS, ... ... Coughlin SR, et al. Local protease signaling contributes to neural tube closure in the mouse embryo. Developmental Cell. 18: 25-38. PMID 20152175 DOI: 10.1016/j.devcel.2009.11.014  0.44
2010 Pham TH, Baluk P, Xu Y, Grigorova I, Bankovich AJ, Pappu R, Coughlin SR, McDonald DM, Schwab SR, Cyster JG. Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning. The Journal of Experimental Medicine. 207: 17-27. PMID 20026661 DOI: 10.1084/jem.20091619  0.44
2009 Camerer E, Regard JB, Cornelissen I, Srinivasan Y, Duong DN, Palmer D, Pham TH, Wong JS, Pappu R, Coughlin SR. Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice. The Journal of Clinical Investigation. 119: 1871-9. PMID 19603543  0.44
2009 Hamilton JR, Cornelissen I, Mountford JK, Coughlin SR. Atherosclerosis proceeds independently of thrombin-induced platelet activation in ApoE-/- mice. Atherosclerosis. 205: 427-32. PMID 19217621 DOI: 10.1016/j.atherosclerosis.2009.01.018  0.44
2009 Li G, Kataoka H, Coughlin SR, Pleasure SJ. Identification of a transient subpial neurogenic zone in the developing dentate gyrus and its regulation by Cxcl12 and reelin signaling. Development (Cambridge, England). 136: 327-35. PMID 19103804 DOI: 10.1242/dev.025742  0.44
2008 Regard JB, Sato IT, Coughlin SR. Anatomical profiling of G protein-coupled receptor expression. Cell. 135: 561-71. PMID 18984166 DOI: 10.1016/j.cell.2008.08.040  0.44
2008 Watanabe N, Bodin L, Pandey M, Krause M, Coughlin S, Boussiotis VA, Ginsberg MH, Shattil SJ. Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin alphaIIbbeta3. The Journal of Cell Biology. 181: 1211-22. PMID 18573917 DOI: 10.1083/jcb.200803094  0.44
2008 Sood R, Sholl L, Isermann B, Zogg M, Coughlin SR, Weiler H. Maternal Par4 and platelets contribute to defective placenta formation in mouse embryos lacking thrombomodulin. Blood. 112: 585-91. PMID 18490515 DOI: 10.1182/blood-2007-09-111302  0.44
2008 Cho J, Furie BC, Coughlin SR, Furie B. A critical role for extracellular protein disulfide isomerase during thrombus formation in mice. The Journal of Clinical Investigation. 118: 1123-31. PMID 18292814 DOI: 10.1172/JCI34134  0.44
2007 Regard JB, Kataoka H, Cano DA, Camerer E, Yin L, Zheng YW, Scanlan TS, Hebrok M, Coughlin SR. Probing cell type-specific functions of Gi in vivo identifies GPCR regulators of insulin secretion. The Journal of Clinical Investigation. 117: 4034-43. PMID 17992256 DOI: 10.1172/JCI32994  0.44
2007 Cottrell GS, Amadesi S, Pikios S, Camerer E, Willardsen JA, Murphy BR, Caughey GH, Wolters PJ, Coughlin SR, Peterson A, Knecht W, Pothoulakis C, Bunnett NW, Grady EF. Protease-activated receptor 2, dipeptidyl peptidase I, and proteases mediate Clostridium difficile toxin A enteritis. Gastroenterology. 132: 2422-37. PMID 17570216 DOI: 10.1053/j.gastro.2007.03.101  0.44
2007 Sood R, Zogg M, Westrick RJ, Guo YH, Kerschen EJ, Girardi G, Salmon JE, Coughlin SR, Weiler H. Fetal gene defects precipitate platelet-mediated pregnancy failure in factor V Leiden mothers. The Journal of Experimental Medicine. 204: 1049-56. PMID 17438064 DOI: 10.1084/jem.20062566  0.44
2007 Pappu R, Schwab SR, Cornelissen I, Pereira JP, Regard JB, Xu Y, Camerer E, Zheng YW, Huang Y, Cyster JG, Coughlin SR. Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. Science (New York, N.Y.). 316: 295-8. PMID 17363629 DOI: 10.1126/science.1139221  0.44
2007 Vandendries ER, Hamilton JR, Coughlin SR, Furie B, Furie BC. Par4 is required for platelet thrombus propagation but not fibrin generation in a mouse model of thrombosis. Proceedings of the National Academy of Sciences of the United States of America. 104: 288-92. PMID 17190826 DOI: 10.1073/pnas.0610188104  0.44
2007 De Candia E, Pecci A, Ciabattoni G, De Cristofaro R, Rutella S, Yao-Wu Z, Lazzareschi I, Landolfi R, Coughlin S, Balduini CL. Defective platelet responsiveness to thrombin and protease-activated receptors agonists in a novel case of gray platelet syndrome: correlation between the platelet defect and the alpha-granule content in the patient and four relatives. Journal of Thrombosis and Haemostasis : Jth. 5: 551-9. PMID 17137471 DOI: 10.1111/j.1538-7836.2006.02329.x  0.44
2006 Camerer E, Cornelissen I, Kataoka H, Duong DN, Zheng YW, Coughlin SR. Roles of protease-activated receptors in a mouse model of endotoxemia. Blood. 107: 3912-21. PMID 16434493 DOI: 10.1182/blood-2005-08-3130  0.44
2005 Coughlin SR. Protease-activated receptors in hemostasis, thrombosis and vascular biology. Journal of Thrombosis and Haemostasis : Jth. 3: 1800-14. PMID 16102047 DOI: 10.1111/j.1538-7836.2005.01377.x  0.44
2005 Su X, Camerer E, Hamilton JR, Coughlin SR, Matthay MA. Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanisms. Journal of Immunology (Baltimore, Md. : 1950). 175: 2598-605. PMID 16081834  0.44
2005 Ruppel KM, Willison D, Kataoka H, Wang A, Zheng YW, Cornelissen I, Yin L, Xu SM, Coughlin SR. Essential role for Galpha13 in endothelial cells during embryonic development. Proceedings of the National Academy of Sciences of the United States of America. 102: 8281-6. PMID 15919816 DOI: 10.1073/pnas.0503326102  0.44
2005 Ludeman MJ, Kataoka H, Srinivasan Y, Esmon NL, Esmon CT, Coughlin SR. PAR1 cleavage and signaling in response to activated protein C and thrombin. The Journal of Biological Chemistry. 280: 13122-8. PMID 15665002 DOI: 10.1074/jbc.M410381200  0.44
2005 Camerer E, Coughlin SR. APC signaling: Tickling PAR1 for barrier protection? Blood. 105: 3004-3005. DOI: 10.1182/blood-2005-01-0334  0.44
2004 Hamilton JR, Cornelissen I, Coughlin SR. Impaired hemostasis and protection against thrombosis in protease-activated receptor 4-deficient mice is due to lack of thrombin signaling in platelets. Journal of Thrombosis and Haemostasis : Jth. 2: 1429-35. PMID 15304051 DOI: 10.1111/j.1538-7836.2004.00783.x  0.44
2004 Camerer E, Qazi AA, Duong DN, Cornelissen I, Advincula R, Coughlin SR. Platelets, protease-activated receptors, and fibrinogen in hematogenous metastasis. Blood. 104: 397-401. PMID 15031212 DOI: 10.1182/blood-2004-02-0434  0.44
2004 Ludeman MJ, Zheng YW, Ishii K, Coughlin SR. Regulated shedding of PAR1 N-terminal exodomain from endothelial cells. The Journal of Biological Chemistry. 279: 18592-9. PMID 14982936 DOI: 10.1074/jbc.M310836200  0.44
2004 Camerer E, Duong DN, Hamilton JR, Coughlin SR. Combined deficiency of protease-activated receptor-4 and fibrinogen recapitulates the hemostatic defect but not the embryonic lethality of prothrombin deficiency. Blood. 103: 152-4. PMID 14504091 DOI: 10.1182/blood-2003-08-2707  0.44
2003 Kataoka H, Hamilton JR, McKemy DD, Camerer E, Zheng YW, Cheng A, Griffin C, Coughlin SR. Protease-activated receptors 1 and 4 mediate thrombin signaling in endothelial cells. Blood. 102: 3224-31. PMID 12869501 DOI: 10.1182/blood-2003-04-1130  0.44
2003 Eisenhaure TM, Francis SA, Willison LD, Coughlin SR, Lerner DJ. The Rho guanine nucleotide exchange factor Lsc homo-oligomerizes and is negatively regulated through domains in its carboxyl terminus that are absent in novel splenic isoforms. The Journal of Biological Chemistry. 278: 30975-84. PMID 12773540 DOI: 10.1074/jbc.M303277200  0.44
2003 Coughlin SR, Camerer E. PARticipation in inflammation. The Journal of Clinical Investigation. 111: 25-7. PMID 12511583 DOI: 10.1172/JCI17564  0.44
2002 Coughlin SR. Protease-activated receptors in the cardiovascular system. Cold Spring Harbor Symposia On Quantitative Biology. 67: 197-208. PMID 12858541  0.44
2002 Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, ... ... Coughlin SR, et al. Overview of the Alliance for Cellular Signaling. Nature. 420: 703-6. PMID 12478301 DOI: 10.1038/nature01304  0.44
2002 Weiss EJ, Hamilton JR, Lease KE, Coughlin SR. Protection against thrombosis in mice lacking PAR3. Blood. 100: 3240-4. PMID 12384423 DOI: 10.1182/blood-2002-05-1470  0.44
2002 Camerer E, Kataoka H, Kahn M, Lease K, Coughlin SR. Genetic evidence that protease-activated receptors mediate factor Xa signaling in endothelial cells. The Journal of Biological Chemistry. 277: 16081-7. PMID 11850418 DOI: 10.1074/jbc.M108555200  0.44
2001 Sambrano GR, Weiss EJ, Zheng YW, Huang W, Coughlin SR. Role of thrombin signalling in platelets in haemostasis and thrombosis. Nature. 413: 74-8. PMID 11544528 DOI: 10.1038/35092573  0.44
2001 Griffin CT, Srinivasan Y, Zheng YW, Huang W, Coughlin SR. A role for thrombin receptor signaling in endothelial cells during embryonic development. Science (New York, N.Y.). 293: 1666-70. PMID 11533492 DOI: 10.1126/science.1061259  0.44
2001 Coughlin SR. Protease-activated receptors in vascular biology. Thrombosis and Haemostasis. 86: 298-307. PMID 11487018  0.44
2000 Lindner JR, Kahn ML, Coughlin SR, Sambrano GR, Schauble E, Bernstein D, Foy D, Hafezi-Moghadam A, Ley K. Delayed onset of inflammation in protease-activated receptor-2-deficient mice. Journal of Immunology (Baltimore, Md. : 1950). 165: 6504-10. PMID 11086091  0.44
2000 Coughlin SR. Thrombin signalling and protease-activated receptors. Nature. 407: 258-64. PMID 11001069 DOI: 10.1038/35025229  0.44
2000 Trejo J, Altschuler Y, Fu HW, Mostov KE, Coughlin SR. Protease-activated receptor-1 down-regulation: a mutant HeLa cell line suggests novel requirements for PAR1 phosphorylation and recruitment to clathrin-coated pits. The Journal of Biological Chemistry. 275: 31255-65. PMID 10893235 DOI: 10.1074/jbc.M003770200  0.44
2000 Shapiro MJ, Weiss EJ, Faruqi TR, Coughlin SR. Protease-activated receptors 1 and 4 are shut off with distinct kinetics after activation by thrombin. The Journal of Biological Chemistry. 275: 25216-21. PMID 10837487 DOI: 10.1074/jbc.M004589200  0.44
2000 Takeuchi T, Harris JL, Huang W, Yan KW, Coughlin SR, Craik CS. Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates. The Journal of Biological Chemistry. 275: 26333-42. PMID 10831593 DOI: 10.1074/jbc.M002941200  0.44
2000 Camerer E, Huang W, Coughlin SR. Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa. Proceedings of the National Academy of Sciences of the United States of America. 97: 5255-60. PMID 10805786 DOI: 10.1073/pnas.97.10.5255  0.44
2000 Faruqi TR, Weiss EJ, Shapiro MJ, Huang W, Coughlin SR. Structure-function analysis of protease-activated receptor 4 tethered ligand peptides. Determinants of specificity and utility in assays of receptor function. The Journal of Biological Chemistry. 275: 19728-34. PMID 10779527 DOI: 10.1074/jbc.M909960199  0.44
2000 Nakanishi-Matsui M, Zheng YW, Sulciner DJ, Weiss EJ, Ludeman MJ, Coughlin SR. PAR3 is a cofactor for PAR4 activation by thrombin. Nature. 404: 609-13. PMID 10766244 DOI: 10.1038/35007085  0.44
2000 Sambrano GR, Huang W, Faruqi T, Mahrus S, Craik C, Coughlin SR. Cathepsin G activates protease-activated receptor-4 in human platelets. The Journal of Biological Chemistry. 275: 6819-23. PMID 10702240 DOI: 10.1074/jbc.275.10.6819  0.44
2000 Cunningham MA, Rondeau E, Chen X, Coughlin SR, Holdsworth SR, Tipping PG. Protease-activated receptor 1 mediates thrombin-dependent, cell-mediated renal inflammation in crescentic glomerulonephritis. The Journal of Experimental Medicine. 191: 455-62. PMID 10662791 DOI: 10.1084/jem.191.3.455  0.44
1999 Coughlin SR. Protease-activated receptors and platelet function. Thrombosis and Haemostasis. 82: 353-6. PMID 10605724  0.44
1999 Kahn ML, Diacovo TG, Bainton DF, Lanza F, Trejo J, Coughlin SR. Glycoprotein V-deficient platelets have undiminished thrombin responsiveness and Do not exhibit a Bernard-Soulier phenotype. Blood. 94: 4112-21. PMID 10590056  0.44
1999 Coughlin SR. How the protease thrombin talks to cells. Proceedings of the National Academy of Sciences of the United States of America. 96: 11023-7. PMID 10500117 DOI: 10.1073/pnas.96.20.11023  0.44
1999 Hammes SR, Shapiro MJ, Coughlin SR. Shutoff and agonist-triggered internalization of protease-activated receptor 1 can be separated by mutation of putative phosphorylation sites in the cytoplasmic tail. Biochemistry. 38: 9308-16. PMID 10413505 DOI: 10.1021/bi9902236  0.44
1999 Sambrano GR, Coughlin SR. The carboxyl tail of protease-activated receptor-1 is required for chemotaxis. Correlation of signal termination and directional migration. The Journal of Biological Chemistry. 274: 20178-84. PMID 10400633 DOI: 10.1074/jbc.274.29.20178  0.44
1999 Kahn ML, Nakanishi-Matsui M, Shapiro MJ, Ishihara H, Coughlin SR. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. The Journal of Clinical Investigation. 103: 879-87. PMID 10079109 DOI: 10.1172/JCI6042  0.44
1999 Hammes SR, Coughlin SR. Protease-activated receptor-1 can mediate responses to SFLLRN in thrombin-desensitized cells: evidence for a novel mechanism for preventing or terminating signaling by PAR1's tethered ligand. Biochemistry. 38: 2486-93. PMID 10029543 DOI: 10.1021/bi982527i  0.44
1999 Trejo J, Coughlin SR. The cytoplasmic tails of protease-activated receptor-1 and substance P receptor specify sorting to lysosomes versus recycling. The Journal of Biological Chemistry. 274: 2216-24. PMID 9890984 DOI: 10.1074/jbc.274.4.2216  0.44
1998 Trejo J, Hammes SR, Coughlin SR. Termination of signaling by protease-activated receptor-1 is linked to lysosomal sorting. Proceedings of the National Academy of Sciences of the United States of America. 95: 13698-702. PMID 9811863 DOI: 10.1073/pnas.95.23.13698  0.44
1998 Shapiro MJ, Coughlin SR. Separate signals for agonist-independent and agonist-triggered trafficking of protease-activated receptor 1. The Journal of Biological Chemistry. 273: 29009-14. PMID 9786906 DOI: 10.1074/jbc.273.44.29009  0.44
1998 Kahn ML, Hammes SR, Botka C, Coughlin SR. Gene and locus structure and chromosomal localization of the protease-activated receptor gene family. The Journal of Biological Chemistry. 273: 23290-6. PMID 9722561 DOI: 10.1074/jbc.273.36.23290  0.44
1998 Kahn ML, Zheng YW, Huang W, Bigornia V, Zeng D, Moff S, Farese RV, Tam C, Coughlin SR. A dual thrombin receptor system for platelet activation. Nature. 394: 690-4. PMID 9716134 DOI: 10.1038/29325  0.44
1998 Ishihara H, Zeng D, Connolly AJ, Tam C, Coughlin SR. Antibodies to protease-activated receptor 3 inhibit activation of mouse platelets by thrombin. Blood. 91: 4152-7. PMID 9596661  0.44
1998 Coughlin SR. Sol Sherry lecture in thrombosis: how thrombin 'talks' to cells: molecular mechanisms and roles in vivo. Arteriosclerosis, Thrombosis, and Vascular Biology. 18: 514-8. PMID 9555855  0.44
1998 Bernstein HS, Coughlin SR. A mammalian homolog of fission yeast Cdc5 regulates G2 progression and mitotic entry. The Journal of Biological Chemistry. 273: 4666-71. PMID 9468527 DOI: 10.1074/jbc.273.8.4666  0.44
1997 An S, Bleu T, Huang W, Hallmark OG, Coughlin SR, Goetzl EJ. Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids. Febs Letters. 417: 279-82. PMID 9409733 DOI: 10.1016/S0014-5793(97)01301-X  0.44
1997 Connolly AJ, Suh DY, Hunt TK, Coughlin SR. Mice lacking the thrombin receptor, PAR1, have normal skin wound healing. The American Journal of Pathology. 151: 1199-204. PMID 9358744  0.44
1997 Ishihara H, Connolly AJ, Zeng D, Kahn ML, Zheng YW, Timmons C, Tram T, Coughlin SR. Protease-activated receptor 3 is a second thrombin receptor in humans. Nature. 386: 502-6. PMID 9087410 DOI: 10.1038/386502a0  0.44
1997 Verrall S, Ishii M, Chen M, Wang L, Tram T, Coughlin SR. The thrombin receptor second cytoplasmic loop confers coupling to Gq-like G proteins in chimeric receptors. Additional evidence for a common transmembrane signaling and G protein coupling mechanism in G protein-coupled receptors. The Journal of Biological Chemistry. 272: 6898-902. PMID 9054376 DOI: 10.1074/jbc.272.11.6898  0.44
1997 Molino M, Bainton DF, Hoxie JA, Coughlin SR, Brass LF. Thrombin receptors on human platelets. Initial localization and subsequent redistribution during platelet activation. The Journal of Biological Chemistry. 272: 6011-7. PMID 9038223 DOI: 10.1074/jbc.272.9.6011  0.44
1997 Bernstein HS, Coughlin SR. Pombe Cdc5-related protein. A putative human transcription factor implicated in mitogen-activated signaling. The Journal of Biological Chemistry. 272: 5833-7. PMID 9038199 DOI: 10.1074/jbc.272.9.5833  0.44
1997 Coughlin SR. The Platelet Thrombin Receptor Advances in Molecular and Cell Biology. 18: 129-143. DOI: 10.1016/S1569-2558(08)60413-0  0.44
1997 Coughlin S. Thrombin signaling in vivo Faseb Journal. 11: A1452.  0.44
1996 Franci C, Gosling J, Tsou CL, Coughlin SR, Charo IF. Phosphorylation by a G protein-coupled kinase inhibits signaling and promotes internalization of the monocyte chemoattractant protein-1 receptor. Critical role of carboxyl-tail serines/threonines in receptor function. Journal of Immunology (Baltimore, Md. : 1950). 157: 5606-12. PMID 8955213  0.44
1996 Shapiro MJ, Trejo J, Zeng D, Coughlin SR. Role of the thrombin receptor's cytoplasmic tail in intracellular trafficking. Distinct determinants for agonist-triggered versus tonic internalization and intracellular localization. The Journal of Biological Chemistry. 271: 32874-80. PMID 8955127 DOI: 10.1074/jbc.271.51.32874  0.44
1996 Brown JL, Stowers L, Baer M, Trejo J, Coughlin S, Chant J. Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway. Current Biology : Cb. 6: 598-605. PMID 8805275  0.44
1996 Kahn M, Ishii K, Kuo WL, Piper M, Connolly A, Shi YP, Wu R, Lin CC, Coughlin SR. Conserved structure and adjacent location of the thrombin receptor and protease-activated receptor 2 genes define a protease-activated receptor gene cluster. Molecular Medicine (Cambridge, Mass.). 2: 349-57. PMID 8784787  0.44
1996 Kranzhöfer R, Clinton SK, Ishii K, Coughlin SR, Fenton JW, Libby P. Thrombin potently stimulates cytokine production in human vascular smooth muscle cells but not in mononuclear phagocytes. Circulation Research. 79: 286-94. PMID 8756006  0.44
1996 Trejo J, Connolly AJ, Coughlin SR. The cloned thrombin receptor is necessary and sufficient for activation of mitogen-activated protein kinase and mitogenesis in mouse lung fibroblasts. Loss of responses in fibroblasts from receptor knockout mice. The Journal of Biological Chemistry. 271: 21536-41. PMID 8702939 DOI: 10.1074/jbc.271.35.21536  0.44
1996 Lerner DJ, Chen M, Tram T, Coughlin SR. Agonist recognition by proteinase-activated receptor 2 and thrombin receptor. Importance of extracellular loop interactions for receptor function. The Journal of Biological Chemistry. 271: 13943-7. PMID 8662993  0.44
1996 Connolly AJ, Ishihara H, Kahn ML, Farese RV, Coughlin SR. Role of the thrombin receptor in development and evidence for a second receptor. Nature. 381: 516-9. PMID 8632823 DOI: 10.1038/381516a0  0.44
1996 Nanevicz T, Wang L, Chen M, Ishii M, Coughlin SR. Thrombin receptor activating mutations. Alteration of an extracellular agonist recognition domain causes constitutive signaling. The Journal of Biological Chemistry. 271: 702-6. PMID 8557676  0.44
1995 Nanevicz T, Ishii M, Wang L, Chen M, Chen J, Turck CW, Cohen FE, Coughlin SR. Mechanisms of thrombin receptor agonist specificity. Chimeric receptors and complementary mutations identify an agonist recognition site. The Journal of Biological Chemistry. 270: 21619-25. PMID 7665575  0.44
1995 Ishii K, Gerszten R, Zheng YW, Welsh JB, Turck CW, Coughlin SR. Determinants of thrombin receptor cleavage. Receptor domains involved, specificity, and role of the P3 aspartate. The Journal of Biological Chemistry. 270: 16435-40. PMID 7608215  0.44
1995 Chen J, Bernstein HS, Chen M, Wang L, Ishii M, Turck CW, Coughlin SR. Tethered ligand library for discovery of peptide agonists. The Journal of Biological Chemistry. 270: 23398-401. PMID 7559498 DOI: 10.1074/jbc.270.40.23398  0.44
1994 Ishii K, Chen J, Ishii M, Koch WJ, Freedman NJ, Lefkowitz RJ, Coughlin SR. Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases. The Journal of Biological Chemistry. 269: 1125-30. PMID 8288570  0.44
1994 Chen J, Ishii M, Wang L, Ishii K, Coughlin SR. Thrombin receptor activation. Confirmation of the intramolecular tethered liganding hypothesis and discovery of an alternative intermolecular liganding mode. The Journal of Biological Chemistry. 269: 16041-5. PMID 8206902  0.44
1994 Gerszten RE, Chen J, Ishii M, Ishii K, Wang L, Nanevicz T, Turck CW, Vu TK, Coughlin SR. Specificity of the thrombin receptor for agonist peptide is defined by its extracellular surface. Nature. 368: 648-51. PMID 8145852 DOI: 10.1038/368648a0  0.44
1994 Mathews II, Padmanabhan KP, Ganesh V, Tulinsky A, Ishii M, Chen J, Turck CW, Coughlin SR, Fenton JW. Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes. Biochemistry. 33: 3266-79. PMID 8136362  0.44
1994 Hein L, Ishii K, Coughlin SR, Kobilka BK. Intracellular targeting and trafficking of thrombin receptors. A novel mechanism for resensitization of a G protein-coupled receptor. The Journal of Biological Chemistry. 269: 27719-26. PMID 7961693  0.44
1993 Ishii K, Hein L, Kobilka B, Coughlin SR. Kinetics of thrombin receptor cleavage on intact cells. Relation to signaling. The Journal of Biological Chemistry. 268: 9780-6. PMID 7683662  0.36
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