Shaun Coughlin - Publications

University of California, San Francisco, San Francisco, CA 

70 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Zhang Q, Zheng YW, Coughlin SR, Shu X. A rapid fluorogenic GPCR - β-arrestin interaction assay. Protein Science : a Publication of the Protein Society. PMID 29411438 DOI: 10.1002/Pro.3385  0.333
2018 Schepis A, Barker A, Srinivasan Y, Balouch E, Zheng Y, Lam I, Clay H, Hsiao CD, Coughlin SR. Protease signaling regulates apical cell extrusion, cell contacts, and proliferation in epithelia. The Journal of Cell Biology. PMID 29301867 DOI: 10.1083/Jcb.201709118  0.65
2016 Coughlin S. PAR1 Antagonists Development and Clinical Utility Blood. 128: SCI-10-SCI-10. DOI: 10.1182/blood.v128.22.sci-10.sci-10  0.479
2014 Aasi J, Abbott BP, Abbott R, Abbott T, Abernathy MR, Accadia T, Acernese F, Ackley K, Adams C, Adams T, Addesso P, Adhikari RX, Affeldt C, Agathos M, Aggarwal N, ... ... Coughlin S, et al. Improved upper limits on the stochastic gravitational-wave background from 2009-2010 LIGO and Virgo data. Physical Review Letters. 113: 231101. PMID 25526109 DOI: 10.1103/Physrevlett.113.231101  0.331
2014 Edelstein LC, Simon LM, Lindsay CR, Kong X, Teruel-Montoya R, Tourdot BE, Chen ES, Ma L, Coughlin S, Nieman M, Holinstat M, Shaw CA, Bray PF. Common variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by race. Blood. 124: 3450-8. PMID 25293779 DOI: 10.1182/Blood-2014-04-572479  0.373
2012 Coughlin SS, Barker A, Dawson A. Ethics and Scientific Integrity in Public Health, Epidemiological and Clinical Research. Public Health Reviews. 34: 71-83. PMID 24532867 DOI: 10.1007/Bf03391657  0.498
2012 Zhang C, Srinivasan Y, Arlow DH, Fung JJ, Palmer D, Zheng Y, Green HF, Pandey A, Dror RO, Shaw DE, Weis WI, Coughlin SR, Kobilka BK. High-resolution crystal structure of human protease-activated receptor 1. Nature. 492: 387-92. PMID 23222541 DOI: 10.1038/Nature11701  0.32
2011 Arnon TI, Xu Y, Lo C, Pham T, An J, Coughlin S, Dorn GW, Cyster JG. GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood. Science (New York, N.Y.). 333: 1898-903. PMID 21960637 DOI: 10.1126/Science.1208248  0.377
2011 Green JA, Suzuki K, Cho B, Willison LD, Palmer D, Allen CD, Schmidt TH, Xu Y, Proia RL, Coughlin SR, Cyster JG. The sphingosine 1-phosphate receptor S1Pâ‚‚ maintains the homeostasis of germinal center B cells and promotes niche confinement. Nature Immunology. 12: 672-80. PMID 21642988 DOI: 10.1038/Ni.2047  0.7
2010 Cornelissen I, Palmer D, David T, Wilsbacher L, Concengco C, Conley P, Pandey A, Coughlin SR. Roles and interactions among protease-activated receptors and P2ry12 in hemostasis and thrombosis. Proceedings of the National Academy of Sciences of the United States of America. 107: 18605-10. PMID 20930120 DOI: 10.1073/Pnas.1013309107  0.307
2010 Camerer E, Barker A, Duong DN, Ganesan R, Kataoka H, Cornelissen I, Darragh MR, Hussain A, Zheng YW, Srinivasan Y, Brown C, Xu SM, Regard JB, Lin CY, Craik CS, ... ... Coughlin SR, et al. Local protease signaling contributes to neural tube closure in the mouse embryo. Developmental Cell. 18: 25-38. PMID 20152175 DOI: 10.1016/J.Devcel.2009.11.014  0.642
2009 Li G, Kataoka H, Coughlin SR, Pleasure SJ. Identification of a transient subpial neurogenic zone in the developing dentate gyrus and its regulation by Cxcl12 and reelin signaling. Development (Cambridge, England). 136: 327-35. PMID 19103804 DOI: 10.1242/dev.025742  0.546
2008 Watanabe N, Bodin L, Pandey M, Krause M, Coughlin S, Boussiotis VA, Ginsberg MH, Shattil SJ. Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin alphaIIbbeta3. The Journal of Cell Biology. 181: 1211-22. PMID 18573917 DOI: 10.1083/Jcb.200803094  0.463
2008 Terpager M, Kataoka H, Cornelissen I, Hamilton J, Coughlin SR. The Role of Gi Signaling in Hematopoiesis. Blood. 112: 1402-1402. DOI: 10.1182/blood.v112.11.1402.1402  0.314
2008 Li G, Kataoka H, Coughlin S, Pleasure S. [P1.20]: Developmental relocation of dentate stem cells to the subgranular zone depends on a transient neurogenic niche International Journal of Developmental Neuroscience. 26: 848-848. DOI: 10.1016/j.ijdevneu.2008.09.070  0.508
2007 De Candia E, Pecci A, Ciabattoni G, De Cristofaro R, Rutella S, Yao-Wu Z, Lazzareschi I, Landolfi R, Coughlin S, Balduini CL. Defective platelet responsiveness to thrombin and protease-activated receptors agonists in a novel case of gray platelet syndrome: correlation between the platelet defect and the alpha-granule content in the patient and four relatives. Journal of Thrombosis and Haemostasis : Jth. 5: 551-9. PMID 17137471 DOI: 10.1111/j.1538-7836.2006.02329.x  0.351
2006 Camerer E, Cornelissen I, Kataoka H, Duong DN, Zheng YW, Coughlin SR. Roles of protease-activated receptors in a mouse model of endotoxemia. Blood. 107: 3912-21. PMID 16434493 DOI: 10.1182/blood-2005-08-3130  0.319
2005 Coughlin SR. Protease-activated receptors in hemostasis, thrombosis and vascular biology. Journal of Thrombosis and Haemostasis : Jth. 3: 1800-14. PMID 16102047 DOI: 10.1111/j.1538-7836.2005.01377.x  0.357
2005 Ruppel KM, Willison D, Kataoka H, Wang A, Zheng YW, Cornelissen I, Yin L, Xu SM, Coughlin SR. Essential role for Galpha13 in endothelial cells during embryonic development. Proceedings of the National Academy of Sciences of the United States of America. 102: 8281-6. PMID 15919816 DOI: 10.1073/pnas.0503326102  0.309
2005 Ludeman MJ, Kataoka H, Srinivasan Y, Esmon NL, Esmon CT, Coughlin SR. PAR1 cleavage and signaling in response to activated protein C and thrombin. The Journal of Biological Chemistry. 280: 13122-8. PMID 15665002 DOI: 10.1074/Jbc.M410381200  0.74
2004 Ludeman MJ, Zheng YW, Ishii K, Coughlin SR. Regulated shedding of PAR1 N-terminal exodomain from endothelial cells. The Journal of Biological Chemistry. 279: 18592-9. PMID 14982936 DOI: 10.1074/Jbc.M310836200  0.742
2003 Kataoka H, Hamilton JR, McKemy DD, Camerer E, Zheng YW, Cheng A, Griffin C, Coughlin SR. Protease-activated receptors 1 and 4 mediate thrombin signaling in endothelial cells. Blood. 102: 3224-31. PMID 12869501 DOI: 10.1182/Blood-2003-04-1130  0.637
2003 Eisenhaure TM, Francis SA, Willison LD, Coughlin SR, Lerner DJ. The Rho guanine nucleotide exchange factor Lsc homo-oligomerizes and is negatively regulated through domains in its carboxyl terminus that are absent in novel splenic isoforms. The Journal of Biological Chemistry. 278: 30975-84. PMID 12773540 DOI: 10.1074/jbc.M303277200  0.701
2002 Camerer E, Kataoka H, Kahn M, Lease K, Coughlin SR. Genetic evidence that protease-activated receptors mediate factor Xa signaling in endothelial cells. The Journal of Biological Chemistry. 277: 16081-7. PMID 11850418 DOI: 10.1074/Jbc.M108555200  0.363
2001 Griffin CT, Srinivasan Y, Zheng YW, Huang W, Coughlin SR. A role for thrombin receptor signaling in endothelial cells during embryonic development. Science (New York, N.Y.). 293: 1666-70. PMID 11533492 DOI: 10.1126/Science.1061259  0.639
2001 Coughlin SR. Protease-activated receptors in vascular biology. Thrombosis and Haemostasis. 86: 298-307. PMID 11487018  0.37
2000 Coughlin SR. Thrombin signalling and protease-activated receptors. Nature. 407: 258-64. PMID 11001069 DOI: 10.1038/35025229  0.349
2000 Trejo J, Altschuler Y, Fu HW, Mostov KE, Coughlin SR. Protease-activated receptor-1 down-regulation: a mutant HeLa cell line suggests novel requirements for PAR1 phosphorylation and recruitment to clathrin-coated pits. The Journal of Biological Chemistry. 275: 31255-65. PMID 10893235 DOI: 10.1074/Jbc.M003770200  0.363
2000 Shapiro MJ, Weiss EJ, Faruqi TR, Coughlin SR. Protease-activated receptors 1 and 4 are shut off with distinct kinetics after activation by thrombin. The Journal of Biological Chemistry. 275: 25216-21. PMID 10837487 DOI: 10.1074/jbc.M004589200  0.359
2000 Camerer E, Huang W, Coughlin SR. Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa. Proceedings of the National Academy of Sciences of the United States of America. 97: 5255-60. PMID 10805786 DOI: 10.1073/pnas.97.10.5255  0.366
2000 Faruqi TR, Weiss EJ, Shapiro MJ, Huang W, Coughlin SR. Structure-function analysis of protease-activated receptor 4 tethered ligand peptides. Determinants of specificity and utility in assays of receptor function. The Journal of Biological Chemistry. 275: 19728-34. PMID 10779527 DOI: 10.1074/jbc.M909960199  0.315
2000 Nakanishi-Matsui M, Zheng YW, Sulciner DJ, Weiss EJ, Ludeman MJ, Coughlin SR. PAR3 is a cofactor for PAR4 activation by thrombin. Nature. 404: 609-13. PMID 10766244 DOI: 10.1038/35007085  0.737
2000 Sambrano GR, Huang W, Faruqi T, Mahrus S, Craik C, Coughlin SR. Cathepsin G activates protease-activated receptor-4 in human platelets. The Journal of Biological Chemistry. 275: 6819-23. PMID 10702240 DOI: 10.1074/Jbc.275.10.6819  0.324
1999 Coughlin SR. Protease-activated receptors and platelet function. Thrombosis and Haemostasis. 82: 353-6. PMID 10605724  0.305
1999 Coughlin SR. How the protease thrombin talks to cells. Proceedings of the National Academy of Sciences of the United States of America. 96: 11023-7. PMID 10500117 DOI: 10.1073/pnas.96.20.11023  0.43
1999 Sambrano GR, Coughlin SR. The carboxyl tail of protease-activated receptor-1 is required for chemotaxis. Correlation of signal termination and directional migration. The Journal of Biological Chemistry. 274: 20178-84. PMID 10400633 DOI: 10.1074/jbc.274.29.20178  0.428
1999 Kahn ML, Nakanishi-Matsui M, Shapiro MJ, Ishihara H, Coughlin SR. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. The Journal of Clinical Investigation. 103: 879-87. PMID 10079109 DOI: 10.1172/Jci6042  0.305
1999 Hammes SR, Coughlin SR. Protease-activated receptor-1 can mediate responses to SFLLRN in thrombin-desensitized cells: evidence for a novel mechanism for preventing or terminating signaling by PAR1's tethered ligand. Biochemistry. 38: 2486-93. PMID 10029543 DOI: 10.1021/bi982527i  0.375
1999 Trejo J, Coughlin SR. The cytoplasmic tails of protease-activated receptor-1 and substance P receptor specify sorting to lysosomes versus recycling. The Journal of Biological Chemistry. 274: 2216-24. PMID 9890984 DOI: 10.1074/Jbc.274.4.2216  0.327
1998 Trejo J, Hammes SR, Coughlin SR. Termination of signaling by protease-activated receptor-1 is linked to lysosomal sorting. Proceedings of the National Academy of Sciences of the United States of America. 95: 13698-702. PMID 9811863 DOI: 10.1073/Pnas.95.23.13698  0.39
1998 Shapiro MJ, Coughlin SR. Separate signals for agonist-independent and agonist-triggered trafficking of protease-activated receptor 1. The Journal of Biological Chemistry. 273: 29009-14. PMID 9786906 DOI: 10.1074/jbc.273.44.29009  0.369
1998 Kahn ML, Zheng YW, Huang W, Bigornia V, Zeng D, Moff S, Farese RV, Tam C, Coughlin SR. A dual thrombin receptor system for platelet activation. Nature. 394: 690-4. PMID 9716134 DOI: 10.1038/29325  0.316
1998 Ishihara H, Zeng D, Connolly AJ, Tam C, Coughlin SR. Antibodies to protease-activated receptor 3 inhibit activation of mouse platelets by thrombin. Blood. 91: 4152-7. PMID 9596661  0.347
1997 Ishihara H, Connolly AJ, Zeng D, Kahn ML, Zheng YW, Timmons C, Tram T, Coughlin SR. Protease-activated receptor 3 is a second thrombin receptor in humans. Nature. 386: 502-6. PMID 9087410 DOI: 10.1038/386502A0  0.373
1997 Verrall S, Ishii M, Chen M, Wang L, Tram T, Coughlin SR. The thrombin receptor second cytoplasmic loop confers coupling to Gq-like G proteins in chimeric receptors. Additional evidence for a common transmembrane signaling and G protein coupling mechanism in G protein-coupled receptors. The Journal of Biological Chemistry. 272: 6898-902. PMID 9054376 DOI: 10.1074/jbc.272.11.6898  0.377
1997 Molino M, Bainton DF, Hoxie JA, Coughlin SR, Brass LF. Thrombin receptors on human platelets. Initial localization and subsequent redistribution during platelet activation. The Journal of Biological Chemistry. 272: 6011-7. PMID 9038223 DOI: 10.1074/Jbc.272.9.6011  0.323
1996 Franci C, Gosling J, Tsou CL, Coughlin SR, Charo IF. Phosphorylation by a G protein-coupled kinase inhibits signaling and promotes internalization of the monocyte chemoattractant protein-1 receptor. Critical role of carboxyl-tail serines/threonines in receptor function. Journal of Immunology (Baltimore, Md. : 1950). 157: 5606-12. PMID 8955213  0.34
1996 Shapiro MJ, Trejo J, Zeng D, Coughlin SR. Role of the thrombin receptor's cytoplasmic tail in intracellular trafficking. Distinct determinants for agonist-triggered versus tonic internalization and intracellular localization. The Journal of Biological Chemistry. 271: 32874-80. PMID 8955127 DOI: 10.1074/Jbc.271.51.32874  0.355
1996 Brown JL, Stowers L, Baer M, Trejo J, Coughlin S, Chant J. Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway. Current Biology : Cb. 6: 598-605. PMID 8805275 DOI: 10.1016/S0960-9822(02)00546-8  0.402
1996 Trejo J, Connolly AJ, Coughlin SR. The cloned thrombin receptor is necessary and sufficient for activation of mitogen-activated protein kinase and mitogenesis in mouse lung fibroblasts. Loss of responses in fibroblasts from receptor knockout mice. The Journal of Biological Chemistry. 271: 21536-41. PMID 8702939 DOI: 10.1074/Jbc.271.35.21536  0.343
1996 Lerner DJ, Chen M, Tram T, Coughlin SR. Agonist recognition by proteinase-activated receptor 2 and thrombin receptor. Importance of extracellular loop interactions for receptor function. The Journal of Biological Chemistry. 271: 13943-7. PMID 8662993  0.313
1996 Connolly AJ, Ishihara H, Kahn ML, Farese RV, Coughlin SR. Role of the thrombin receptor in development and evidence for a second receptor. Nature. 381: 516-9. PMID 8632823 DOI: 10.1038/381516A0  0.376
1996 Nanevicz T, Wang L, Chen M, Ishii M, Coughlin SR. Thrombin receptor activating mutations. Alteration of an extracellular agonist recognition domain causes constitutive signaling. The Journal of Biological Chemistry. 271: 702-6. PMID 8557676 DOI: 10.1074/jbc.271.2.702  0.339
1996 Kahn M, Ishii K, Kuo W, Piper M, Connolly A, Shi Y, Wu R, Lin CC, Coughlin SR. Conserved Structure and Adjacent Location of the Thrombin Receptor and Protease-Activated Receptor 2 Genes Define a Protease-Activated Receptor Gene Cluster Molecular Medicine. 2: 349-357. DOI: 10.1007/Bf03401632  0.327
1995 Ishii K, Gerszten R, Zheng YW, Welsh JB, Turck CW, Coughlin SR. Determinants of thrombin receptor cleavage. Receptor domains involved, specificity, and role of the P3 aspartate. The Journal of Biological Chemistry. 270: 16435-40. PMID 7608215  0.327
1994 Ishii K, Chen J, Ishii M, Koch WJ, Freedman NJ, Lefkowitz RJ, Coughlin SR. Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases. The Journal of Biological Chemistry. 269: 1125-30. PMID 8288570  0.367
1994 Chen J, Ishii M, Wang L, Ishii K, Coughlin SR. Thrombin receptor activation. Confirmation of the intramolecular tethered liganding hypothesis and discovery of an alternative intermolecular liganding mode. The Journal of Biological Chemistry. 269: 16041-5. PMID 8206902  0.329
1994 Hein L, Ishii K, Coughlin SR, Kobilka BK. Intracellular targeting and trafficking of thrombin receptors. A novel mechanism for resensitization of a G protein-coupled receptor. The Journal of Biological Chemistry. 269: 27719-26. PMID 7961693  0.327
1993 Ishii K, Hein L, Kobilka B, Coughlin SR. Kinetics of thrombin receptor cleavage on intact cells. Relation to signaling. The Journal of Biological Chemistry. 268: 9780-6. PMID 7683662  0.341
1992 Coughlin SR, Vu TK, Hung DT, Wheaton VI. Expression cloning and characterization of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Seminars in Thrombosis and Hemostasis. 18: 161-6. PMID 1321504 DOI: 10.1055/s-2007-1002422  0.312
1992 Hung DT, Vu TK, Wheaton VI, Ishii K, Coughlin SR. Cloned platelet thrombin receptor is necessary for thrombin-induced platelet activation. The Journal of Clinical Investigation. 89: 1350-3. PMID 1313452 DOI: 10.1172/Jci115721  0.31
1992 Hung DT, Vu TK, Wheaton VI, Charo IF, Nelken NA, Esmon N, Esmon CT, Coughlin SR. "Mirror image" antagonists of thrombin-induced platelet activation based on thrombin receptor structure. The Journal of Clinical Investigation. 89: 444-50. PMID 1310695 DOI: 10.1172/Jci115604  0.318
1992 Hung DT, Vu TH, Nelken NA, Coughlin SR. Thrombin-induced events in non-platelet cells are mediated by the unique proteolytic mechanism established for the cloned platelet thrombin receptor. The Journal of Cell Biology. 116: 827-32. PMID 1309820 DOI: 10.1083/Jcb.116.3.827  0.339
1991 Vu TK, Wheaton VI, Hung DT, Charo I, Coughlin SR. Domains specifying thrombin-receptor interaction. Nature. 353: 674-7. PMID 1717851 DOI: 10.1038/353674a0  0.327
1991 Vu TK, Hung DT, Wheaton VI, Coughlin SR. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell. 64: 1057-68. PMID 1672265 DOI: 10.1016/0092-8674(91)90261-V  0.341
1989 Coughlin SR, Escobedo JA, Williams LT. Role of phosphatidylinositol kinase in PDGF receptor signal transduction. Science (New York, N.Y.). 243: 1191-4. PMID 2466336 DOI: 10.1126/Science.2466336  0.409
1988 Kacich RL, Williams LT, Coughlin SR. Arachidonic acid and cyclic adenosine monophosphate stimulation of c-fos expression by a pathway independent of phorbol ester-sensitive protein kinase C. Molecular Endocrinology (Baltimore, Md.). 2: 73-7. PMID 2840568 DOI: 10.1210/Mend-2-1-73  0.306
1988 Escobedo JA, Navankasatussas S, Cousens LS, Coughlin SR, Bell GI, Williams LT. A common PDGF receptor is activated by homodimeric A and B forms of PDGF. Science (New York, N.Y.). 240: 1532-4. PMID 2836953 DOI: 10.1126/Science.2836953  0.339
1987 Williams LT, Escobedo JA, Keating MT, Coughlin SR. The stimulation of paracrine and autocrine mitogenic pathways by the platelet-derived growth factor receptor. Journal of Cellular Physiology. Supplement. 27-30. PMID 2824531 DOI: 10.1002/Jcp.1041330406  0.364
1985 Garrett JS, Coughlin SR, Niman HL, Tremble PM, Giels GM, Williams LT. Blockade of autocrine stimulation in simian sarcoma virus-transformed cells reverses down-regulation of platelet-derived growth factor receptors. Proceedings of the National Academy of Sciences of the United States of America. 81: 7466-70. PMID 6095298 DOI: 10.1073/Pnas.81.23.7466  0.302
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