| Year |
Citation |
Score |
| 2018 |
Zhang Q, Zheng YW, Coughlin SR, Shu X. A rapid fluorogenic GPCR - β-arrestin interaction assay. Protein Science : a Publication of the Protein Society. PMID 29411438 DOI: 10.1002/Pro.3385 |
0.333 |
|
| 2018 |
Schepis A, Barker A, Srinivasan Y, Balouch E, Zheng Y, Lam I, Clay H, Hsiao CD, Coughlin SR. Protease signaling regulates apical cell extrusion, cell contacts, and proliferation in epithelia. The Journal of Cell Biology. PMID 29301867 DOI: 10.1083/Jcb.201709118 |
0.649 |
|
| 2016 |
Coughlin S. PAR1 Antagonists Development and Clinical Utility Blood. 128: SCI-10-SCI-10. DOI: 10.1182/blood.v128.22.sci-10.sci-10 |
0.479 |
|
| 2014 |
Aasi J, Abbott BP, Abbott R, Abbott T, Abernathy MR, Accadia T, Acernese F, Ackley K, Adams C, Adams T, Addesso P, Adhikari RX, Affeldt C, Agathos M, Aggarwal N, ... ... Coughlin S, et al. Improved upper limits on the stochastic gravitational-wave background from 2009-2010 LIGO and Virgo data. Physical Review Letters. 113: 231101. PMID 25526109 DOI: 10.1103/Physrevlett.113.231101 |
0.331 |
|
| 2014 |
Edelstein LC, Simon LM, Lindsay CR, Kong X, Teruel-Montoya R, Tourdot BE, Chen ES, Ma L, Coughlin S, Nieman M, Holinstat M, Shaw CA, Bray PF. Common variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by race. Blood. 124: 3450-8. PMID 25293779 DOI: 10.1182/Blood-2014-04-572479 |
0.373 |
|
| 2012 |
Coughlin SS, Barker A, Dawson A. Ethics and Scientific Integrity in Public Health, Epidemiological and Clinical Research. Public Health Reviews. 34: 71-83. PMID 24532867 DOI: 10.1007/Bf03391657 |
0.497 |
|
| 2012 |
Zhang C, Srinivasan Y, Arlow DH, Fung JJ, Palmer D, Zheng Y, Green HF, Pandey A, Dror RO, Shaw DE, Weis WI, Coughlin SR, Kobilka BK. High-resolution crystal structure of human protease-activated receptor 1. Nature. 492: 387-92. PMID 23222541 DOI: 10.1038/Nature11701 |
0.32 |
|
| 2011 |
Arnon TI, Xu Y, Lo C, Pham T, An J, Coughlin S, Dorn GW, Cyster JG. GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood. Science (New York, N.Y.). 333: 1898-903. PMID 21960637 DOI: 10.1126/Science.1208248 |
0.377 |
|
| 2011 |
Green JA, Suzuki K, Cho B, Willison LD, Palmer D, Allen CD, Schmidt TH, Xu Y, Proia RL, Coughlin SR, Cyster JG. The sphingosine 1-phosphate receptor S1Pâ‚‚ maintains the homeostasis of germinal center B cells and promotes niche confinement. Nature Immunology. 12: 672-80. PMID 21642988 DOI: 10.1038/Ni.2047 |
0.7 |
|
| 2010 |
Cornelissen I, Palmer D, David T, Wilsbacher L, Concengco C, Conley P, Pandey A, Coughlin SR. Roles and interactions among protease-activated receptors and P2ry12 in hemostasis and thrombosis. Proceedings of the National Academy of Sciences of the United States of America. 107: 18605-10. PMID 20930120 DOI: 10.1073/Pnas.1013309107 |
0.307 |
|
| 2010 |
Camerer E, Barker A, Duong DN, Ganesan R, Kataoka H, Cornelissen I, Darragh MR, Hussain A, Zheng YW, Srinivasan Y, Brown C, Xu SM, Regard JB, Lin CY, Craik CS, ... ... Coughlin SR, et al. Local protease signaling contributes to neural tube closure in the mouse embryo. Developmental Cell. 18: 25-38. PMID 20152175 DOI: 10.1016/J.Devcel.2009.11.014 |
0.641 |
|
| 2009 |
Li G, Kataoka H, Coughlin SR, Pleasure SJ. Identification of a transient subpial neurogenic zone in the developing dentate gyrus and its regulation by Cxcl12 and reelin signaling. Development (Cambridge, England). 136: 327-35. PMID 19103804 DOI: 10.1242/dev.025742 |
0.546 |
|
| 2008 |
Watanabe N, Bodin L, Pandey M, Krause M, Coughlin S, Boussiotis VA, Ginsberg MH, Shattil SJ. Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin alphaIIbbeta3. The Journal of Cell Biology. 181: 1211-22. PMID 18573917 DOI: 10.1083/Jcb.200803094 |
0.463 |
|
| 2008 |
Terpager M, Kataoka H, Cornelissen I, Hamilton J, Coughlin SR. The Role of Gi Signaling in Hematopoiesis. Blood. 112: 1402-1402. DOI: 10.1182/blood.v112.11.1402.1402 |
0.314 |
|
| 2008 |
Li G, Kataoka H, Coughlin S, Pleasure S. [P1.20]: Developmental relocation of dentate stem cells to the subgranular zone depends on a transient neurogenic niche International Journal of Developmental Neuroscience. 26: 848-848. DOI: 10.1016/j.ijdevneu.2008.09.070 |
0.507 |
|
| 2007 |
De Candia E, Pecci A, Ciabattoni G, De Cristofaro R, Rutella S, Yao-Wu Z, Lazzareschi I, Landolfi R, Coughlin S, Balduini CL. Defective platelet responsiveness to thrombin and protease-activated receptors agonists in a novel case of gray platelet syndrome: correlation between the platelet defect and the alpha-granule content in the patient and four relatives. Journal of Thrombosis and Haemostasis : Jth. 5: 551-9. PMID 17137471 DOI: 10.1111/j.1538-7836.2006.02329.x |
0.351 |
|
| 2006 |
Camerer E, Cornelissen I, Kataoka H, Duong DN, Zheng YW, Coughlin SR. Roles of protease-activated receptors in a mouse model of endotoxemia. Blood. 107: 3912-21. PMID 16434493 DOI: 10.1182/blood-2005-08-3130 |
0.318 |
|
| 2005 |
Coughlin SR. Protease-activated receptors in hemostasis, thrombosis and vascular biology. Journal of Thrombosis and Haemostasis : Jth. 3: 1800-14. PMID 16102047 DOI: 10.1111/j.1538-7836.2005.01377.x |
0.357 |
|
| 2005 |
Ruppel KM, Willison D, Kataoka H, Wang A, Zheng YW, Cornelissen I, Yin L, Xu SM, Coughlin SR. Essential role for Galpha13 in endothelial cells during embryonic development. Proceedings of the National Academy of Sciences of the United States of America. 102: 8281-6. PMID 15919816 DOI: 10.1073/pnas.0503326102 |
0.308 |
|
| 2005 |
Ludeman MJ, Kataoka H, Srinivasan Y, Esmon NL, Esmon CT, Coughlin SR. PAR1 cleavage and signaling in response to activated protein C and thrombin. The Journal of Biological Chemistry. 280: 13122-8. PMID 15665002 DOI: 10.1074/Jbc.M410381200 |
0.74 |
|
| 2004 |
Ludeman MJ, Zheng YW, Ishii K, Coughlin SR. Regulated shedding of PAR1 N-terminal exodomain from endothelial cells. The Journal of Biological Chemistry. 279: 18592-9. PMID 14982936 DOI: 10.1074/Jbc.M310836200 |
0.742 |
|
| 2003 |
Kataoka H, Hamilton JR, McKemy DD, Camerer E, Zheng YW, Cheng A, Griffin C, Coughlin SR. Protease-activated receptors 1 and 4 mediate thrombin signaling in endothelial cells. Blood. 102: 3224-31. PMID 12869501 DOI: 10.1182/Blood-2003-04-1130 |
0.633 |
|
| 2003 |
Eisenhaure TM, Francis SA, Willison LD, Coughlin SR, Lerner DJ. The Rho guanine nucleotide exchange factor Lsc homo-oligomerizes and is negatively regulated through domains in its carboxyl terminus that are absent in novel splenic isoforms. The Journal of Biological Chemistry. 278: 30975-84. PMID 12773540 DOI: 10.1074/jbc.M303277200 |
0.701 |
|
| 2002 |
Camerer E, Kataoka H, Kahn M, Lease K, Coughlin SR. Genetic evidence that protease-activated receptors mediate factor Xa signaling in endothelial cells. The Journal of Biological Chemistry. 277: 16081-7. PMID 11850418 DOI: 10.1074/Jbc.M108555200 |
0.363 |
|
| 2001 |
Griffin CT, Srinivasan Y, Zheng YW, Huang W, Coughlin SR. A role for thrombin receptor signaling in endothelial cells during embryonic development. Science (New York, N.Y.). 293: 1666-70. PMID 11533492 DOI: 10.1126/Science.1061259 |
0.636 |
|
| 2001 |
Coughlin SR. Protease-activated receptors in vascular biology. Thrombosis and Haemostasis. 86: 298-307. PMID 11487018 |
0.37 |
|
| 2000 |
Coughlin SR. Thrombin signalling and protease-activated receptors. Nature. 407: 258-64. PMID 11001069 DOI: 10.1038/35025229 |
0.348 |
|
| 2000 |
Trejo J, Altschuler Y, Fu HW, Mostov KE, Coughlin SR. Protease-activated receptor-1 down-regulation: a mutant HeLa cell line suggests novel requirements for PAR1 phosphorylation and recruitment to clathrin-coated pits. The Journal of Biological Chemistry. 275: 31255-65. PMID 10893235 DOI: 10.1074/Jbc.M003770200 |
0.363 |
|
| 2000 |
Shapiro MJ, Weiss EJ, Faruqi TR, Coughlin SR. Protease-activated receptors 1 and 4 are shut off with distinct kinetics after activation by thrombin. The Journal of Biological Chemistry. 275: 25216-21. PMID 10837487 DOI: 10.1074/jbc.M004589200 |
0.359 |
|
| 2000 |
Camerer E, Huang W, Coughlin SR. Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa. Proceedings of the National Academy of Sciences of the United States of America. 97: 5255-60. PMID 10805786 DOI: 10.1073/pnas.97.10.5255 |
0.366 |
|
| 2000 |
Faruqi TR, Weiss EJ, Shapiro MJ, Huang W, Coughlin SR. Structure-function analysis of protease-activated receptor 4 tethered ligand peptides. Determinants of specificity and utility in assays of receptor function. The Journal of Biological Chemistry. 275: 19728-34. PMID 10779527 DOI: 10.1074/jbc.M909960199 |
0.315 |
|
| 2000 |
Nakanishi-Matsui M, Zheng YW, Sulciner DJ, Weiss EJ, Ludeman MJ, Coughlin SR. PAR3 is a cofactor for PAR4 activation by thrombin. Nature. 404: 609-13. PMID 10766244 DOI: 10.1038/35007085 |
0.737 |
|
| 2000 |
Sambrano GR, Huang W, Faruqi T, Mahrus S, Craik C, Coughlin SR. Cathepsin G activates protease-activated receptor-4 in human platelets. The Journal of Biological Chemistry. 275: 6819-23. PMID 10702240 DOI: 10.1074/Jbc.275.10.6819 |
0.324 |
|
| 1999 |
Coughlin SR. Protease-activated receptors and platelet function. Thrombosis and Haemostasis. 82: 353-6. PMID 10605724 |
0.305 |
|
| 1999 |
Coughlin SR. How the protease thrombin talks to cells. Proceedings of the National Academy of Sciences of the United States of America. 96: 11023-7. PMID 10500117 DOI: 10.1073/pnas.96.20.11023 |
0.43 |
|
| 1999 |
Sambrano GR, Coughlin SR. The carboxyl tail of protease-activated receptor-1 is required for chemotaxis. Correlation of signal termination and directional migration. The Journal of Biological Chemistry. 274: 20178-84. PMID 10400633 DOI: 10.1074/jbc.274.29.20178 |
0.427 |
|
| 1999 |
Kahn ML, Nakanishi-Matsui M, Shapiro MJ, Ishihara H, Coughlin SR. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. The Journal of Clinical Investigation. 103: 879-87. PMID 10079109 DOI: 10.1172/Jci6042 |
0.305 |
|
| 1999 |
Hammes SR, Coughlin SR. Protease-activated receptor-1 can mediate responses to SFLLRN in thrombin-desensitized cells: evidence for a novel mechanism for preventing or terminating signaling by PAR1's tethered ligand. Biochemistry. 38: 2486-93. PMID 10029543 DOI: 10.1021/bi982527i |
0.375 |
|
| 1999 |
Trejo J, Coughlin SR. The cytoplasmic tails of protease-activated receptor-1 and substance P receptor specify sorting to lysosomes versus recycling. The Journal of Biological Chemistry. 274: 2216-24. PMID 9890984 DOI: 10.1074/Jbc.274.4.2216 |
0.327 |
|
| 1998 |
Trejo J, Hammes SR, Coughlin SR. Termination of signaling by protease-activated receptor-1 is linked to lysosomal sorting. Proceedings of the National Academy of Sciences of the United States of America. 95: 13698-702. PMID 9811863 DOI: 10.1073/Pnas.95.23.13698 |
0.39 |
|
| 1998 |
Shapiro MJ, Coughlin SR. Separate signals for agonist-independent and agonist-triggered trafficking of protease-activated receptor 1. The Journal of Biological Chemistry. 273: 29009-14. PMID 9786906 DOI: 10.1074/jbc.273.44.29009 |
0.369 |
|
| 1998 |
Kahn ML, Zheng YW, Huang W, Bigornia V, Zeng D, Moff S, Farese RV, Tam C, Coughlin SR. A dual thrombin receptor system for platelet activation. Nature. 394: 690-4. PMID 9716134 DOI: 10.1038/29325 |
0.316 |
|
| 1998 |
Ishihara H, Zeng D, Connolly AJ, Tam C, Coughlin SR. Antibodies to protease-activated receptor 3 inhibit activation of mouse platelets by thrombin. Blood. 91: 4152-7. PMID 9596661 |
0.347 |
|
| 1997 |
Ishihara H, Connolly AJ, Zeng D, Kahn ML, Zheng YW, Timmons C, Tram T, Coughlin SR. Protease-activated receptor 3 is a second thrombin receptor in humans. Nature. 386: 502-6. PMID 9087410 DOI: 10.1038/386502A0 |
0.373 |
|
| 1997 |
Verrall S, Ishii M, Chen M, Wang L, Tram T, Coughlin SR. The thrombin receptor second cytoplasmic loop confers coupling to Gq-like G proteins in chimeric receptors. Additional evidence for a common transmembrane signaling and G protein coupling mechanism in G protein-coupled receptors. The Journal of Biological Chemistry. 272: 6898-902. PMID 9054376 DOI: 10.1074/jbc.272.11.6898 |
0.377 |
|
| 1997 |
Molino M, Bainton DF, Hoxie JA, Coughlin SR, Brass LF. Thrombin receptors on human platelets. Initial localization and subsequent redistribution during platelet activation. The Journal of Biological Chemistry. 272: 6011-7. PMID 9038223 DOI: 10.1074/Jbc.272.9.6011 |
0.323 |
|
| 1996 |
Franci C, Gosling J, Tsou CL, Coughlin SR, Charo IF. Phosphorylation by a G protein-coupled kinase inhibits signaling and promotes internalization of the monocyte chemoattractant protein-1 receptor. Critical role of carboxyl-tail serines/threonines in receptor function. Journal of Immunology (Baltimore, Md. : 1950). 157: 5606-12. PMID 8955213 |
0.34 |
|
| 1996 |
Shapiro MJ, Trejo J, Zeng D, Coughlin SR. Role of the thrombin receptor's cytoplasmic tail in intracellular trafficking. Distinct determinants for agonist-triggered versus tonic internalization and intracellular localization. The Journal of Biological Chemistry. 271: 32874-80. PMID 8955127 DOI: 10.1074/Jbc.271.51.32874 |
0.354 |
|
| 1996 |
Brown JL, Stowers L, Baer M, Trejo J, Coughlin S, Chant J. Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway. Current Biology : Cb. 6: 598-605. PMID 8805275 DOI: 10.1016/S0960-9822(02)00546-8 |
0.402 |
|
| 1996 |
Trejo J, Connolly AJ, Coughlin SR. The cloned thrombin receptor is necessary and sufficient for activation of mitogen-activated protein kinase and mitogenesis in mouse lung fibroblasts. Loss of responses in fibroblasts from receptor knockout mice. The Journal of Biological Chemistry. 271: 21536-41. PMID 8702939 DOI: 10.1074/Jbc.271.35.21536 |
0.343 |
|
| 1996 |
Lerner DJ, Chen M, Tram T, Coughlin SR. Agonist recognition by proteinase-activated receptor 2 and thrombin receptor. Importance of extracellular loop interactions for receptor function. The Journal of Biological Chemistry. 271: 13943-7. PMID 8662993 |
0.313 |
|
| 1996 |
Connolly AJ, Ishihara H, Kahn ML, Farese RV, Coughlin SR. Role of the thrombin receptor in development and evidence for a second receptor. Nature. 381: 516-9. PMID 8632823 DOI: 10.1038/381516A0 |
0.376 |
|
| 1996 |
Nanevicz T, Wang L, Chen M, Ishii M, Coughlin SR. Thrombin receptor activating mutations. Alteration of an extracellular agonist recognition domain causes constitutive signaling. The Journal of Biological Chemistry. 271: 702-6. PMID 8557676 DOI: 10.1074/jbc.271.2.702 |
0.339 |
|
| 1996 |
Kahn M, Ishii K, Kuo W, Piper M, Connolly A, Shi Y, Wu R, Lin CC, Coughlin SR. Conserved Structure and Adjacent Location of the Thrombin Receptor and Protease-Activated Receptor 2 Genes Define a Protease-Activated Receptor Gene Cluster Molecular Medicine. 2: 349-357. DOI: 10.1007/Bf03401632 |
0.327 |
|
| 1995 |
Ishii K, Gerszten R, Zheng YW, Welsh JB, Turck CW, Coughlin SR. Determinants of thrombin receptor cleavage. Receptor domains involved, specificity, and role of the P3 aspartate. The Journal of Biological Chemistry. 270: 16435-40. PMID 7608215 |
0.327 |
|
| 1994 |
Ishii K, Chen J, Ishii M, Koch WJ, Freedman NJ, Lefkowitz RJ, Coughlin SR. Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases. The Journal of Biological Chemistry. 269: 1125-30. PMID 8288570 |
0.367 |
|
| 1994 |
Chen J, Ishii M, Wang L, Ishii K, Coughlin SR. Thrombin receptor activation. Confirmation of the intramolecular tethered liganding hypothesis and discovery of an alternative intermolecular liganding mode. The Journal of Biological Chemistry. 269: 16041-5. PMID 8206902 |
0.329 |
|
| 1994 |
Hein L, Ishii K, Coughlin SR, Kobilka BK. Intracellular targeting and trafficking of thrombin receptors. A novel mechanism for resensitization of a G protein-coupled receptor. The Journal of Biological Chemistry. 269: 27719-26. PMID 7961693 |
0.327 |
|
| 1993 |
Ishii K, Hein L, Kobilka B, Coughlin SR. Kinetics of thrombin receptor cleavage on intact cells. Relation to signaling. The Journal of Biological Chemistry. 268: 9780-6. PMID 7683662 |
0.341 |
|
| 1992 |
Coughlin SR, Vu TK, Hung DT, Wheaton VI. Expression cloning and characterization of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Seminars in Thrombosis and Hemostasis. 18: 161-6. PMID 1321504 DOI: 10.1055/s-2007-1002422 |
0.312 |
|
| 1992 |
Hung DT, Vu TK, Wheaton VI, Ishii K, Coughlin SR. Cloned platelet thrombin receptor is necessary for thrombin-induced platelet activation. The Journal of Clinical Investigation. 89: 1350-3. PMID 1313452 DOI: 10.1172/Jci115721 |
0.31 |
|
| 1992 |
Hung DT, Vu TK, Wheaton VI, Charo IF, Nelken NA, Esmon N, Esmon CT, Coughlin SR. "Mirror image" antagonists of thrombin-induced platelet activation based on thrombin receptor structure. The Journal of Clinical Investigation. 89: 444-50. PMID 1310695 DOI: 10.1172/Jci115604 |
0.318 |
|
| 1992 |
Hung DT, Vu TH, Nelken NA, Coughlin SR. Thrombin-induced events in non-platelet cells are mediated by the unique proteolytic mechanism established for the cloned platelet thrombin receptor. The Journal of Cell Biology. 116: 827-32. PMID 1309820 DOI: 10.1083/Jcb.116.3.827 |
0.339 |
|
| 1991 |
Vu TK, Wheaton VI, Hung DT, Charo I, Coughlin SR. Domains specifying thrombin-receptor interaction. Nature. 353: 674-7. PMID 1717851 DOI: 10.1038/353674a0 |
0.327 |
|
| 1991 |
Vu TK, Hung DT, Wheaton VI, Coughlin SR. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell. 64: 1057-68. PMID 1672265 DOI: 10.1016/0092-8674(91)90261-V |
0.341 |
|
| 1989 |
Coughlin SR, Escobedo JA, Williams LT. Role of phosphatidylinositol kinase in PDGF receptor signal transduction. Science (New York, N.Y.). 243: 1191-4. PMID 2466336 DOI: 10.1126/Science.2466336 |
0.409 |
|
| 1988 |
Kacich RL, Williams LT, Coughlin SR. Arachidonic acid and cyclic adenosine monophosphate stimulation of c-fos expression by a pathway independent of phorbol ester-sensitive protein kinase C. Molecular Endocrinology (Baltimore, Md.). 2: 73-7. PMID 2840568 DOI: 10.1210/Mend-2-1-73 |
0.306 |
|
| 1988 |
Escobedo JA, Navankasatussas S, Cousens LS, Coughlin SR, Bell GI, Williams LT. A common PDGF receptor is activated by homodimeric A and B forms of PDGF. Science (New York, N.Y.). 240: 1532-4. PMID 2836953 DOI: 10.1126/Science.2836953 |
0.339 |
|
| 1987 |
Williams LT, Escobedo JA, Keating MT, Coughlin SR. The stimulation of paracrine and autocrine mitogenic pathways by the platelet-derived growth factor receptor. Journal of Cellular Physiology. Supplement. 27-30. PMID 2824531 DOI: 10.1002/Jcp.1041330406 |
0.364 |
|
| 1985 |
Garrett JS, Coughlin SR, Niman HL, Tremble PM, Giels GM, Williams LT. Blockade of autocrine stimulation in simian sarcoma virus-transformed cells reverses down-regulation of platelet-derived growth factor receptors. Proceedings of the National Academy of Sciences of the United States of America. 81: 7466-70. PMID 6095298 DOI: 10.1073/Pnas.81.23.7466 |
0.302 |
|
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