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David W. Koh, Ph.D. - Publications

Affiliations: 
2001 University of Kentucky, Lexington, KY 
Area:
Biochemistry
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28 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Koh DW, Powell DP, Blake SD, Hoffman JL, Hopkins MM, Feng X. Enhanced cytotoxicity in triple-negative and estrogen receptor‑positive breast adenocarcinoma cells due to inhibition of the transient receptor potential melastatin-2 channel. Oncology Reports. 34: 1589-98. PMID 26178079 DOI: 10.3892/Or.2015.4131  0.381
2015 Hopkins MM, Feng X, Liu M, Parker LP, Koh DW. Inhibition of the transient receptor potential melastatin-2 channel causes increased DNA damage and decreased proliferation in breast adenocarcinoma cells. International Journal of Oncology. 46: 2267-76. PMID 25760245 DOI: 10.3892/Ijo.2015.2919  0.354
2015 Koh DW, Powell DP, Blake SD, Hoffman JL, Feng X. Abstract 1717: Selective induction of breast adenocarcinoma cell death via inhibition of the transient receptor potential melastatin-2 (TRPM2) cation channel Cancer Research. 75: 1717-1717. DOI: 10.1158/1538-7445.Am2015-1717  0.307
2013 Feng X, Koh DW. Roles of poly(ADP-ribose) glycohydrolase in DNA damage and apoptosis. International Review of Cell and Molecular Biology. 304: 227-81. PMID 23809438 DOI: 10.1016/B978-0-12-407696-9.00005-1  0.413
2013 Feng X, Koh DW. Inhibition of poly(ADP-ribose) polymerase-1 or poly(ADP‑ribose) glycohydrolase individually, but not in combination, leads to improved chemotherapeutic efficacy in HeLa cells. International Journal of Oncology. 42: 749-56. PMID 23254695 DOI: 10.3892/Ijo.2012.1740  0.424
2012 Feng X, Zhou Y, Proctor AM, Hopkins MM, Liu M, Koh DW. Silencing of Apoptosis-Inducing factor and poly(ADP-ribose) glycohydrolase reveals novel roles in breast cancer cell death after chemotherapy. Molecular Cancer. 11: 48. PMID 22839996 DOI: 10.1186/1476-4598-11-48  0.373
2012 Feng X, Proctor A, Hopkins M, Liu M, Koh DW. Abstract 2019: Investigation of cell death mediated by poly(ADP-ribose), Apoptosis-Inducing Factor (AIF) and caspases in breast cancer cells by RNA interference Cancer Research. 72: 2019-2019. DOI: 10.1158/1538-7445.Am2012-2019  0.394
2011 Zhou Y, Koh DW. Poly(ADP-ribosyl)ation pathways in mammals: the advantage of murine PARG null mutation. Methods in Molecular Biology (Clifton, N.J.). 780: 337-48. PMID 21870270 DOI: 10.1007/978-1-61779-270-0_20  0.421
2011 Zhou Y, Feng X, Koh DW. Synergistic cytotoxicity of N-methyl-N'-nitro-N-nitrosoguanidine and absence of poly(ADP-ribose) glycohydrolase involves chromatin decondensation. International Journal of Oncology. 39: 121-7. PMID 21519789 DOI: 10.3892/Ijo.2011.1013  0.397
2011 Zhou Y, Feng X, Koh DW. Activation of cell death mediated by apoptosis-inducing factor due to the absence of poly(ADP-ribose) glycohydrolase. Biochemistry. 50: 2850-9. PMID 21366272 DOI: 10.1021/Bi101829R  0.404
2011 Zhou Y, Feng X, Koh DW. Abstract 4092: Alteration of caspase-mediated events following DNA damage due to the absence of poly(ADP-ribose) glycohydrolase Cancer Research. 71: 4092-4092. DOI: 10.1158/1538-7445.Am2011-4092  0.402
2011 Feng X, Zhou Y, Koh DW. Abstract 2146: Role of apoptosis-inducing factor in the death of MDA-MB-231 breast carcinoma cells after DNA damage Cancer Research. 71: 2146-2146. DOI: 10.1158/1538-7445.Am2011-2146  0.391
2010 Zhou Y, Feng X, Koh DW. Enhanced DNA accessibility and increased DNA damage induced by the absence of poly(ADP-ribose) hydrolysis. Biochemistry. 49: 7360-6. PMID 20687516 DOI: 10.1021/Bi100979J  0.36
2010 Zhou Y, Feng X, Koh DW. Abstract 3931: Elevated levels of poly(ADP-ribose) lead to enhanced efficacy of DNA-damaging chemotherapeutic agents Cancer Research. 70: 3931-3931. DOI: 10.1158/1538-7445.Am10-3931  0.363
2010 Feng X, Zhou Y, Koh DW. Abstract 1270: Elevated levels of poly(ADP-ribose) lead to novel apoptotic signaling and the induction of caspase-independent cell death Cancer Research. 70: 1270-1270. DOI: 10.1158/1538-7445.Am10-1270  0.406
2007 Poitras MF, Koh DW, Yu SW, Andrabi SA, Mandir AS, Poirier GG, Dawson VL, Dawson TM. Spatial and functional relationship between poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase in the brain. Neuroscience. 148: 198-211. PMID 17640816 DOI: 10.1016/J.Neuroscience.2007.04.062  0.349
2006 Andrabi SA, Kim NS, Yu SW, Wang H, Koh DW, Sasaki M, Klaus JA, Otsuka T, Zhang Z, Koehler RC, Hurn PD, Poirier GG, Dawson VL, Dawson TM. Poly(ADP-ribose) (PAR) polymer is a death signal. Proceedings of the National Academy of Sciences of the United States of America. 103: 18308-13. PMID 17116882 DOI: 10.1073/Pnas.0606526103  0.381
2006 Kofler J, Otsuka T, Zhang Z, Noppens R, Grafe MR, Koh DW, Dawson VL, de Murcia JM, Hurn PD, Traystman RJ. Differential effect of PARP-2 deletion on brain injury after focal and global cerebral ischemia. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 26: 135-41. PMID 15959455 DOI: 10.1038/Sj.Jcbfm.9600173  0.337
2005 Koh DW, Dawson TM, Dawson VL. Mediation of cell death by poly(ADP-ribose) polymerase-1. Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 52: 5-14. PMID 15911329 DOI: 10.1016/J.Phrs.2005.02.011  0.403
2005 Koh DW, Dawson TM, Dawson VL. Poly(ADP-ribosyl)ation regulation of life and death in the nervous system. Cellular and Molecular Life Sciences : Cmls. 62: 760-8. PMID 15868401 DOI: 10.1007/S00018-004-4508-Y  0.365
2005 Koh DW, Dawson VL, Dawson TM. The road to survival goes through PARG. Cell Cycle (Georgetown, Tex.). 4: 397-9. PMID 15725727 DOI: 10.4161/Cc.4.3.1559  0.363
2005 Patel CN, Koh DW, Jacobson MK, Oliveira MA. Identification of three critical acidic residues of poly(ADP-ribose) glycohydrolase involved in catalysis: determining the PARG catalytic domain. The Biochemical Journal. 388: 493-500. PMID 15658938 DOI: 10.1042/Bj20040942  0.547
2004 Koh DW, Lawler AM, Poitras MF, Sasaki M, Wattler S, Nehls MC, Stöger T, Poirier GG, Dawson VL, Dawson TM. Failure to degrade poly(ADP-ribose) causes increased sensitivity to cytotoxicity and early embryonic lethality. Proceedings of the National Academy of Sciences of the United States of America. 101: 17699-704. PMID 15591342 DOI: 10.1073/Pnas.0406182101  0.352
2004 Wang H, Yu SW, Koh DW, Lew J, Coombs C, Bowers W, Federoff HJ, Poirier GG, Dawson TM, Dawson VL. Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 10963-73. PMID 15574746 DOI: 10.1523/Jneurosci.3461-04.2004  0.333
2003 Koh DW, Coyle DL, Mehta N, Ramsinghani S, Kim H, Slama JT, Jacobson MK. SAR analysis of adenosine diphosphate (hydroxymethyl)pyrrolidinediol inhibition of poly(ADP-ribose) glycohydrolase. Journal of Medicinal Chemistry. 46: 4322-32. PMID 13678410 DOI: 10.1021/Jm020541U  0.573
2003 Koh DW, Patel CN, Ramsinghani S, Slama JT, Oliveira MA, Jacobson MK. Identification of an inhibitor binding site of poly(ADP-ribose) glycohydrolase. Biochemistry. 42: 4855-63. PMID 12718526 DOI: 10.1021/Bi0272048  0.566
1998 Shieh WM, Amé JC, Wilson MV, Wang ZQ, Koh DW, Jacobson MK, Jacobson EL. Poly(ADP-ribose) polymerase null mouse cells synthesize ADP-ribose polymers. The Journal of Biological Chemistry. 273: 30069-72. PMID 9804757 DOI: 10.1074/jbc.273.46.30069  0.565
1998 Ramsinghani S, Koh DW, Amé JC, Strohm M, Jacobson MK, Slama JT. Syntheses of photoactive analogues of adenosine diphosphate (hydroxymethyl)pyrrolidinediol and photoaffinity labeling of poly(ADP-ribose) glycohydrolase. Biochemistry. 37: 7801-12. PMID 9601041 DOI: 10.1021/Bi9730386  0.57
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