Orest Hurko, M.D. - Publications

Clinical Biologics Consulting Group, Inc. 
Mendelian disorders

83 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2014 Hurko O. The Skin and Neurologic Disease Aminoff's Neurology and General Medicine: Fifth Edition. 401-430. DOI: 10.1016/B978-0-12-407710-2.00021-7  0.68
2013 Berger JR, Choi D, Kaminski HJ, Gordon MF, Hurko O, D'Cruz O, Pleasure SJ, Feldman EL. Importance and hurdles to drug discovery for neurological disease. Annals of Neurology. 74: 441-6. PMID 25813523 DOI: 10.1002/Ana.23997  0.68
2013 Hurko O. Drug development for rare mitochondrial disorders. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 10: 286-306. PMID 23430661 DOI: 10.1007/s13311-013-0179-4  0.68
2012 Hurko O. Target-based drug discovery, genetic diseases, and biologics. Neurochemistry International. 61: 892-8. PMID 22306775 DOI: 10.1016/j.neuint.2012.01.016  0.68
2012 Hurko O, Black SE, Doody R, Doraiswamy PM, Gamst A, Kaye J, Obisesan TO, Rusinek H, Scharre D, Sperling R, Weiner MW, Green RC. The ADNI Publication Policy: commensurate recognition of critical contributors who are not authors. Neuroimage. 59: 4196-200. PMID 22100665 DOI: 10.1016/J.Neuroimage.2011.10.085  0.68
2011 Hurko O, Jones GK. Valuation of biomarkers. Nature Reviews. Drug Discovery. 10: 253-4. PMID 21455229 DOI: 10.1038/nrd3417  0.68
2010 Hurko O, Boudonck K, Gonzales C, Hughes ZA, Jacobsen JS, Reinhart PH, Crowther D. Ablation of the locus coeruleus increases oxidative stress in tg-2576 transgenic but not wild-type mice. International Journal of Alzheimer's Disease. 2010: 864625. PMID 20981353 DOI: 10.4061/2010/864625  0.68
2010 Hurko O. Future drug discovery and development. Molecular Genetics and Metabolism. 100: S92-6. PMID 20189856 DOI: 10.1016/j.ymgme.2010.01.010  0.68
2009 Hurko O. The uses of biomarkers in drug development. Annals of the New York Academy of Sciences. 1180: 1-10. PMID 19906255 DOI: 10.1111/j.1749-6632.2009.04946.x  0.68
2009 Chavez JC, Hurko O, Barone FC, Feuerstein GZ. Pharmacologic interventions for stroke: looking beyond the thrombolysis time window into the penumbra with biomarkers, not a stopwatch. Stroke; a Journal of Cerebral Circulation. 40: e558-63. PMID 19745180 DOI: 10.1161/STROKEAHA.109.559914  0.68
2009 Chavez JC, Zaleska MM, Wang X, Wood A, Hurko O, Pangalos MN, Feuerstein GZ. Multimodal magnetic resonance imaging for assessing evolution of ischemic penumbra: a key translational medicine strategy to manage the risk of developing novel therapies for acute ischemic stroke. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 29: 217-9. PMID 18766199 DOI: 10.1038/jcbfm.2008.103  0.68
2009 Wan HI, Kling MA, Day M, Chavez J, Feuerstein G, Hurko O, Pangalos MN. Imaging of CNS systems: Importance for drug development Imaging in Cns Drug Discovery and Development: Implications For Disease and Therapy. 11-28. DOI: 10.1007/978-1-4419-0134-7_2  0.68
2009 Wan HI, Hurko O, Day M, Rutkowski JL. Translational medicine perspective in development of disease modifying therapies for alzheimer's disease: Biomarkers to buy down the risk Drug Development Research. 70: 60-69. DOI: 10.1002/ddr.20292  0.68
2009 Wan HI, Day M, Hurko O, Rutkowski JL. Biomarkers for Alzheimer's disease: Translational medicine approaches in development of disease modifying therapeutics part 2: Neuroimaging and cognitive paradigms asBiomarkers for AD drug development American Pharmaceutical Review. 12.  0.68
2008 Shen S, Lang B, Nakamoto C, Zhang F, Pu J, Kuan SL, Chatzi C, He S, Mackie I, Brandon NJ, Marquis KL, Day M, Hurko O, McCaig CD, Riedel G, et al. Schizophrenia-related neural and behavioral phenotypes in transgenic mice expressing truncated Disc1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 10893-904. PMID 18945897 DOI: 10.1523/JNEUROSCI.3299-08.2008  0.68
2008 Feuerstein G, Gill D, Dormer C, Ruffolo RR, Rutkowski JL, Walsh FS, Hurko O. The vastly neglected biomarkers contributing to early clinical development failure American Pharmaceutical Review. 11.  0.68
2007 Pangalos MN, Schechter LE, Hurko O. Drug development for CNS disorders: strategies for balancing risk and reducing attrition. Nature Reviews. Drug Discovery. 6: 521-32. PMID 17599084 DOI: 10.1038/nrd2094  0.68
2006 Hurko O. The impact of preclinical drug safety on R&D productivity. Expert Opinion On Drug Discovery. 1: 369-72. PMID 23495908 DOI: 10.1517/17460441.1.4.369  0.68
2006 Hurko O. Understanding the strategic importance of biomarkers for the discovery and early development phases Drug Discovery World. 7: 63-74.  0.68
2005 Hurko O, Ryan JL. Translational research in central nervous system drug discovery. Neurorx : the Journal of the American Society For Experimental Neurotherapeutics. 2: 671-82. PMID 16489374 DOI: 10.1602/neurorx.2.4.671  0.68
2001 Hurko O. Genetics and genomics in neuropsychopharmacology: the impact on drug discovery and development. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 11: 491-9. PMID 11704426 DOI: 10.1016/S0924-977X(01)00126-2  0.68
2001 McGinnis RE, Fox H, Yates P, Cameron LA, Barnes MR, Gray IC, Spurr NK, Hurko O, St Clair D. Failure to confirm NOTCH4 association with schizophrenia in a large population-based sample from Scotland. Nature Genetics. 28: 128-9. PMID 11381258 DOI: 10.1038/88839  0.68
2000 Hurko O, Walsh FS. Novel drug development for amyotrophic lateral sclerosis. Journal of the Neurological Sciences. 180: 21-8. PMID 11090860 DOI: 10.1016/S0022-510X(00)00419-6  0.68
2000 Wright MJ, Ain MC, Clough MV, Bellus GA, Hurko O, McIntosh I. Achondroplasia and nail-patella syndrome: the compound phenotype. Journal of Medical Genetics. 37: E25. PMID 10978372 DOI: 10.1136/Jmg.37.9.E25  0.68
2000 Crockett MM, Carten MF, Hurko O, Sponseller PD. Motor milestones in children with diastrophic dysplasia. Journal of Pediatric Orthopedics. 20: 437-41. PMID 10912597 DOI: 10.1097/00004694-200007000-00004  0.68
2000 Elmaci I, Ain MC, Wright MJ, Lee RR, Sheppard JM, Rigamonti D, Hurko O. Perioperative intracranial hemorrhage in achondroplasia: a case report. Journal of Neurosurgical Anesthesiology. 12: 217-20. PMID 10905569 DOI: 10.1097/00008506-200007000-00003  0.68
2000 Ain MC, Elmaci I, Hurko O, Clatterbuck RE, Lee RR, Rigamonti D. Reoperation for spinal restenosis in achondroplasia. Journal of Spinal Disorders. 13: 168-73. PMID 10780694 DOI: 10.1097/00002517-200004000-00013  0.68
1999 Bellus GA, Bamshad MJ, Przylepa KA, Dorst J, Lee RR, Hurko O, Jabs EW, Curry CJ, Wilcox WR, Lachman RS, Rimoin DL, Francomano CA. Severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN): phenotypic analysis of a new skeletal dysplasia caused by a Lys650Met mutation in fibroblast growth factor receptor 3. American Journal of Medical Genetics. 85: 53-65. PMID 10377013 DOI: 10.1002/(SICI)1096-8628(19990702)85:1<53::AID-AJMG10>3.0.CO;2-F  0.68
1999 Becher MW, Wills ML, Noll WW, Hurko O, Price DL. Kearns-Sayre syndrome with features of Pearson's marrow-pancreas syndrome and a novel 2905-base pair mitochondrial DNA deletion. Human Pathology. 30: 577-81. PMID 10333230 DOI: 10.1016/S0046-8177(99)90204-6  0.68
1999 Hurko O, Provost TT. Neurology and the skin. Journal of Neurology, Neurosurgery, and Psychiatry. 66: 417-30. PMID 10201411 DOI: 10.1136/Jnnp.66.4.417  0.68
1999 Crawford TO, Sladky JT, Hurko O, Besner-Johnston A, Kelley RI. Abnormal fatty acid metabolism in childhood spinal muscular atrophy. Annals of Neurology. 45: 337-43. PMID 10072048 DOI: 10.1002/1531-8249(199903)45:3<337::AID-ANA9>3.0.CO;2-U  0.68
1998 Mogayzel PJ, Carroll JL, Loughlin GM, Hurko O, Francomano CA, Marcus CL. Sleep-disordered breathing in children with achondroplasia. The Journal of Pediatrics. 132: 667-71. PMID 9580768 DOI: 10.1016/S0022-3476(98)70358-0  0.68
1997 Hurko O. The explosion of neurogenetics. Current Opinion in Neurology. 10: 77-83. PMID 9146987 DOI: 10.1097/00019052-199704000-00001  0.68
1997 Polymeropoulos MH, Hurko O, Hsu F, Rubenstein J, Basnet S, Lane K, Dietz H, Spetzler RF, Rigamonti D. Linkage of the locus for cerebral cavernous hemangiomas to human chromosome 7q in four families of Mexican-American descent. Neurology. 48: 752-7. PMID 9065560 DOI: 10.1212/WNL.48.3.752  0.68
1997 Hurko O. Recent advances in heritable ataxias. Annals of Neurology. 41: 4-6. PMID 9005858 DOI: 10.1002/ana.410410103  0.68
1996 Versino M, Hurko O, Zee DS. Disorders of binocular control of eye movements in patients with cerebellar dysfunction. Brain : a Journal of Neurology. 119: 1933-50. PMID 9009999 DOI: 10.1093/brain/119.6.1933  0.68
1996 Tager JM, Moser HW, Barker PB, Barth PG, Boltshauser E, Campagnoni AT, Dawson G, DeVivo DC, Federico A, Fluharty AL, Gieselmann V, Hodes ME, Hurko O, Jaeken J, Kruse B, et al. The MRI suggests a leukodystrophy, but tests are negative - What should we do? Probing white-matter disorders Molecular and Chemical Neuropathology. 27: 1-106. PMID 8790669  0.68
1996 Walkup JT, LaBuda MC, Singer HS, Brown J, Riddle MA, Hurko O. Family study and segregation analysis of Tourette syndrome: evidence for a mixed model of inheritance. American Journal of Human Genetics. 59: 684-93. PMID 8751870  0.68
1996 Hofhaus G, Johns DR, Hurko O, Attardi G, Chomyn A. Respiration and growth defects in transmitochondrial cell lines carrying the 11778 mutation associated with Leber's hereditary optic neuropathy. The Journal of Biological Chemistry. 271: 13155-61. PMID 8662757 DOI: 10.1074/Jbc.271.22.13155  0.68
1995 Zeidman SM, Monsein LH, Arosarena O, Aletich V, Biafore JA, Dawson RC, Debrun GM, Hurko O. Reversibility of white matter changes and dementia after treatment of dural fistulas. Ajnr. American Journal of Neuroradiology. 16: 1080-3. PMID 7543726  0.68
1994 Burghes AH, Ingraham SE, Kóte-Jarai Z, Rosenfeld S, Herta N, Nadkarni N, DiDonato CJ, Carpten J, Hurko O, Florence J. Linkage mapping of the spinal muscular atrophy gene. Human Genetics. 93: 305-12. PMID 8125483 DOI: 10.1007/BF00212028  0.68
1994 DiDonato CJ, Morgan K, Carpten JD, Fuerst P, Ingraham SE, Prescott G, McPherson JD, Wirth B, Zerres K, Hurko O. Association between Ag1-CA alleles and severity of autosomal recessive proximal spinal muscular atrophy. American Journal of Human Genetics. 55: 1218-29. PMID 7977383  0.68
1994 Uematsu S, Wang H, Kopits SE, Hurko O. Total craniospinal decompression in achondroplastic stenosis. Neurosurgery. 35: 250-7; discussion 25. PMID 7969832 DOI: 10.1227/00006123-199408000-00010  0.68
1994 Spencer F, Hugerat Y, Simchen G, Hurko O, Connelly C, Hieter P. Yeast kar1 mutants provide an effective method for YAC transfer to new hosts. Genomics. 22: 118-26. PMID 7959757 DOI: 10.1006/geno.1994.1352  0.68
1994 Hurko O. Mitochondrial DNA mutations in Leber's optic neuropathy. Annals of Neurology. 35: 636. PMID 7910006 DOI: 10.1002/ana.410350523  0.68
1993 Johns DR, Threlkeld AB, Miller NR, Hurko O. Multiple mitochondrial DNA deletions in myo-neuro-gastrointestinal encephalopathy syndrome. American Journal of Ophthalmology. 115: 108-9. PMID 8420360 DOI: 10.1016/S0002-9394(14)73533-0  0.68
1993 Lebo RV, Martelli L, Su Y, Li L, Lynch E, Mansfield E, Pua KH, Watson DF, Chueh J, Hurko O. Prenatal diagnosis of Charcot-Marie-Tooth disease type 1A by multicolor in situ hybridization. American Journal of Medical Genetics. 47: 441-50. PMID 8135298 DOI: 10.1002/ajmg.1320470334  0.68
1993 Lebo RV, Chance PF, Dyck PJ, Redila-Flores MT, Lynch ED, Golbus MS, Bird TD, King MC, Anderson LA, Hall J, Wiegant J, Jiang Z, Dazin PF, Punnett HH, Schonberg SA, ... ... Hurko O, et al. Chromosome 1 Charcot-Marie-Tooth disease (CMT1B) locus in the Fcγ receptor gene region Human Genetics. 91: 301. DOI: 10.1007/BF00218282  0.68
1993 Hurko O, Uematsu S. Neurosurgical considerations in skeletal dysplasias Neurosurgery Quarterly. 3: 192-217.  0.68
1992 Lunardi J, Hurko O, Engel WK, Attardi G. The multiple ADP/ATP translocase genes are differentially expressed during human muscle development. The Journal of Biological Chemistry. 267: 15267-70. PMID 1639771  0.68
1992 Chomyn A, Martinuzzi A, Yoneda M, Daga A, Hurko O, Johns D, Lai ST, Nonaka I, Angelini C, Attardi G. MELAS mutation in mtDNA binding site for transcription termination factor causes defects in protein synthesis and in respiration but no change in levels of upstream and downstream mature transcripts. Proceedings of the National Academy of Sciences of the United States of America. 89: 4221-5. PMID 1584755 DOI: 10.1073/Pnas.89.10.4221  0.68
1992 Threlkeld AB, Miller NR, Golnik KC, Griffin JW, Kuncl RW, Johns DR, Lehar M, Hurko O. Ophthalmic involvement in myo-neuro-gastrointestinal encephalopathy syndrome. American Journal of Ophthalmology. 114: 322-8. PMID 1524123 DOI: 10.1016/S0002-9394(14)71799-4  0.68
1992 Yoneda M, Chomyn A, Martinuzzi A, Hurko O, Attardi G. Marked replicative advantage of human mtDNA carrying a point mutation that causes the MELAS encephalomyopathy. Proceedings of the National Academy of Sciences of the United States of America. 89: 11164-8. PMID 1454794 DOI: 10.1073/Pnas.89.23.11164  0.68
1992 Shuper A, Derossett S, Hurko O. Confusion as the presenting manifestation of vertebral osteomyelitis: a case report. Israel Journal of Medical Sciences. 28: 864-8. PMID 1286957  0.68
1991 Lebo RV, Chance PF, Dyck PJ, Redila-Flores MT, Lynch ED, Golbus MS, Bird TD, King MC, Anderson LA, Hall J. Chromosome 1 Charcot-Marie-Tooth disease (CMT1B) locus in the Fc gamma receptor gene region. Human Genetics. 88: 1-12. PMID 1683643 DOI: 10.1007/Bf00204921  0.68
1991 Johns DR, Hurko O. Mitochondrial leucine tRNA mutation in neurological diseases. Lancet. 337: 927-8. PMID 1673015 DOI: 10.1016/0140-6736(91)90272-Q  0.68
1990 Aryanpur J, Hurko O, Francomano C, Wang H, Carson B. Craniocervical decompression for cervicomedullary compression in pediatric patients with achondroplasia. Journal of Neurosurgery. 73: 375-82. PMID 2384775 DOI: 10.3171/jns.1990.73.3.0375  0.68
1990 Eleff SM, Barker PB, Blackband SJ, Chatham JC, Lutz NW, Johns DR, Bryan RN. Phosphorus magnetic resonance spectroscopy of patients with mitochondrial cytopathies demonstrates decreased levels of brain phosphocreatine. Annals of Neurology. 27: 626-30. PMID 2360799 DOI: 10.1002/Ana.410270607  0.68
1990 Hurko O, Johns DR, Rutledge SL, Stine OC, Peterson PL, Miller NR, Martens ME, Drachman DB, Brown RH, Lee CP. Heteroplasmy in chronic external ophthalmoplegia: clinical and molecular observations. Pediatric Research. 28: 542-8. PMID 2255577 DOI: 10.1203/00006450-199011000-00026  0.68
1990 Eleff SM, Barker PB, Blackband SJ, Chatham JC, Bryan RN, Hurko O. Phosphorus magnetic resonance spectroscopy of brain in mitochondrial cytopathies (Reply) Annals of Neurology. 28: 840.  0.68
1989 Johns DR, Rutledge SL, Stine OC, Hurko O. Directly repeated sequences associated with pathogenic mitochondrial DNA deletions. Proceedings of the National Academy of Sciences of the United States of America. 86: 8059-62. PMID 2813377 DOI: 10.1073/Pnas.86.20.8059  0.68
1989 Rosen SA, Wang H, Cornblath DR, Uematsu S, Hurko O. Compression syndromes due to hypertrophic nerve roots in hereditary motor sensory neuropathy type I. Neurology. 39: 1173-7. PMID 2771067 DOI: 10.1212/Wnl.39.9.1173  0.68
1989 Hurko O, Johns DR. Dystrophin and Duchenne's muscular dystrophy. The New England Journal of Medicine. 321: 398-9. PMID 2664525 DOI: 10.1056/NEJM198908103210616  0.68
1989 Hurko O, Hoffman EP, McKee L, Johns DR, Kunkel LM. Dystrophin analysis in clonal myoblasts derived from a Duchenne muscular dystrophy carrier. American Journal of Human Genetics. 44: 820-6. PMID 2658563  0.68
1989 Johns DR, Drachman DB, Hurko O. Identical mitochondrial DNA deletion in blood and muscle. Lancet. 1: 393-4. PMID 2563557 DOI: 10.1016/S0140-6736(89)91779-0  0.68
1989 Johns DR, Hurko O. Preferential amplification and molecular characterization of junction sequences of a pathogenetic deletion in human mitochondrial DNA. Genomics. 5: 623-8. PMID 2533162 DOI: 10.1016/0888-7543(89)90032-3  0.68
1988 Gahl WA, Bernardini I, Dalakas M, Rizzo WB, Harper GS, Hoeg JM, Hurko O, Bernar J. Oral carnitine therapy in children with cystinosis and renal Fanconi syndrome. The Journal of Clinical Investigation. 81: 549-60. PMID 3276734 DOI: 10.1172/JCI113353  0.68
1988 Uematsu S, Wang H, Hurko O, Kopits SE. The subarachnoid fluid space in achondroplastic spinal stenosis: the surgical implication. Basic Life Sciences. 48: 275-81. PMID 3240262 DOI: 10.1007/978-1-4684-8712-1_37  0.68
1988 Streeten E, Uematsu S, Hurko O, Kopits S, Murphy E, Pyeritz R. Extended laminectomy for spinal stenosis in achondroplasia. Basic Life Sciences. 48: 261-73. PMID 3240261 DOI: 10.1007/978-1-4684-8712-1_36  0.68
1988 Reid CS, Pyeritz RE, Kopits SE, Maria BL, Wang H, McPherson RW, Hurko O, Phillips JA. Cervicomedullary cord compression in young children with achondroplasia: value of comprehensive neurologic and respiratory evaluation. Basic Life Sciences. 48: 199-206. PMID 3240254 DOI: 10.1007/978-1-4684-8712-1_29  0.68
1988 Hurko O, Pyeritz R, Uematsu S. Neurological considerations in achondroplasia. Basic Life Sciences. 48: 153-62. PMID 3240245 DOI: 10.1007/978-1-4684-8712-1_21  0.68
1987 Harper GS, Bernardini I, Hurko O, Zuurveld J, Gahl WA. Cystine storage in cultured myotubes from patients with nephropathic cystinosis. The Biochemical Journal. 243: 841-5. PMID 3663103 DOI: 10.1042/bj2430841  0.68
1987 Hurko O, McKee L, Zuurveld J, Swick HM. Comparison of Duchenne and normal myoblasts from a heterozygote. Neurology. 37: 675-81. PMID 3561779 DOI: 10.1212/Wnl.37.4.675  0.68
1987 Reid CS, Pyeritz RE, Kopits SE, Maria BL, Wang H, McPherson RW, Hurko O, Phillips JA, Rosenbaum AE. Cervicomedullary compression in young patients with achondroplasia: value of comprehensive neurologic and respiratory evaluation. The Journal of Pediatrics. 110: 522-30. PMID 3559799 DOI: 10.1016/S0022-3476(87)80542-5  0.68
1987 Peden K, Hurko O, Tennekoon G. Establishment of cell lines from primary cultures by transfection with SV40 large T antigen gene. Progress in Clinical and Biological Research. 253: 101-9. PMID 2829233  0.68
1986 Moore SE, Hurko O, Walsh FS. Novel antigens at the neuromuscular junction. Journal of Neuroimmunology. 10: 185-200. PMID 3510228 DOI: 10.1016/0165-5728(86)90101-3  0.68
1986 Hurko O, McKee L, Zuurveld JG. Transfection of human skeletal muscle cells with SV40 large T antigen gene coupled to a metallothionein promoter. Annals of Neurology. 20: 573-82. PMID 3024558 DOI: 10.1002/ana.410200504  0.68
1984 Moore SE, Hurko O, Walsh FS. Immunocytochemical analysis of fibre type differentiation in developing skeletal muscle. Journal of Neuroimmunology. 7: 137-49. PMID 6392332 DOI: 10.1016/S0165-5728(84)80014-4  0.68
1983 Hurko O, Walsh FS. Human fetal muscle-specific antigen is restricted to regenerating myofibers in diseased adult muscle. Neurology. 33: 737-43. PMID 6188996 DOI: 10.1212/Wnl.33.6.737  0.68
1979 Aarabi B, Pasternak G, Hurko O, Long DM. Familial intradural arachnoid cysts. Report of two cases. Journal of Neurosurgery. 50: 826-9. PMID 438888 DOI: 10.3171/Jns.1979.50.6.0826  0.68
1978 Hurko O. Specific [3H]quinuclidinyl benzilate binding activity in digitonin-solubilized preparations from bovine brain. Archives of Biochemistry and Biophysics. 190: 434-45. PMID 718161 DOI: 10.1016/0003-9861(78)90296-5  0.68
1974 Hurko O, Elster P, Wurtman RJ. Adenylate cyclase activity in bovine adrenal medulla. Endocrinology. 94: 591-3. PMID 4359134 DOI: 10.1210/endo-94-2-591  0.68
1972 Lytle LD, Hurko O, Romero JA, Cottman K, Leehey D, Wurtman RJ. The effects of 6-hydroxydopamine pretreatment on the accumulation of dopa and dopamine in brain and peripheral organs following L-dopa administration. Journal of Neural Transmission. 33: 63-71. PMID 4641868 DOI: 10.1007/BF01244728  0.68
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