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R. John Mayer, PhD - Publications

Affiliations: 
School of Biomedical Sciences University of Nottingham, Nottingham, England, United Kingdom 
Website:
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50 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2014 Kageyama S, Sou YS, Uemura T, Kametaka S, Saito T, Ishimura R, Kouno T, Bedford L, Mayer RJ, Lee MS, Yamamoto M, Waguri S, Tanaka K, Komatsu M. Proteasome dysfunction activates autophagy and the Keap1-Nrf2 pathway. The Journal of Biological Chemistry. 289: 24944-55. PMID 25049227 DOI: 10.1074/Jbc.M114.580357  0.319
2013 Elkharaz J, Ugun-Klusek A, Constantin-Teodosiu D, Lawler K, Mayer RJ, Billett E, Lowe J, Bedford L. Implications for oxidative stress and astrocytes following 26S proteasomal depletion in mouse forebrain neurones. Biochimica Et Biophysica Acta. 1832: 1930-8. PMID 23851049 DOI: 10.1016/J.Bbadis.2013.07.002  0.334
2013 Paine SM, Anderson G, Bedford K, Lawler K, Mayer RJ, Lowe J, Bedford L. Pale body-like inclusion formation and neurodegeneration following depletion of 26S proteasomes in mouse brain neurones are independent of α-synuclein. Plos One. 8: e54711. PMID 23382946 DOI: 10.1371/Journal.Pone.0054711  0.321
2012 Rezvani N, Elkharaz J, Lawler K, Mee M, Mayer RJ, Bedford L. Heterozygosity for the proteasomal Psmc1 ATPase is insufficient to cause neuropathology in mouse brain, but causes cell cycle defects in mouse embryonic fibroblasts. Neuroscience Letters. 521: 130-5. PMID 22677101 DOI: 10.1016/J.Neulet.2012.05.070  0.366
2011 Paine S, Lowe J, Bedford L, Mayer RJ. Can neurodegeneration be separated from neuropathological hallmarks of chronic idiopathic human neurodegenerative disease? A perspective from modelling! Biochemical Society Transactions. 39: 917-9. PMID 21787323 DOI: 10.1042/Bst0390917  0.352
2011 Bedford L, Layfield R, Mayer RJ, Peng J, Xu P. Diverse polyubiquitin chains accumulate following 26S proteasomal dysfunction in mammalian neurones. Neuroscience Letters. 491: 44-7. PMID 21215295 DOI: 10.1016/J.Neulet.2010.12.064  0.337
2011 Bedford L, Lowe J, Dick LR, Mayer RJ, Brownell JE. Ubiquitin-like protein conjugation and the ubiquitin-proteasome system as drug targets. Nature Reviews. Drug Discovery. 10: 29-46. PMID 21151032 DOI: 10.1038/Nrd3321  0.364
2010 Bedford L, Paine S, Sheppard PW, Mayer RJ, Roelofs J. Assembly, structure, and function of the 26S proteasome. Trends in Cell Biology. 20: 391-401. PMID 20427185 DOI: 10.1016/J.Tcb.2010.03.007  0.339
2009 Paine S, Bedford L, Thorpe JR, Mayer RJ, Cavey JR, Bajaj N, Sheppard PW, Lowe J, Layfield R. Immunoreactivity to Lys63-linked polyubiquitin is a feature of neurodegeneration. Neuroscience Letters. 460: 205-8. PMID 19500650 DOI: 10.1016/J.Neulet.2009.05.074  0.36
2009 Bedford L, Paine S, Rezvani N, Mee M, Lowe J, Mayer RJ. The UPS and autophagy in chronic neurodegenerative disease: six of one and half a dozen of the other--or not? Autophagy. 5: 224-7. PMID 19077533 DOI: 10.4161/Auto.5.2.7389  0.367
2008 Bedford L, Hay D, Paine S, Rezvani N, Mee M, Lowe J, Mayer RJ. Is malfunction of the ubiquitin proteasome system the primary cause of alpha-synucleinopathies and other chronic human neurodegenerative disease? Biochimica Et Biophysica Acta. 1782: 683-90. PMID 18976704 DOI: 10.1016/J.Bbadis.2008.10.009  0.381
2008 Layfield R, Mayer RJ. The ubiquitin proteasome system in human disease. Biochimica Et Biophysica Acta. 1782: 681-2. PMID 18845251 DOI: 10.1016/J.Bbadis.2008.09.002  0.303
2008 Bedford L, Hay D, Devoy A, Paine S, Powe DG, Seth R, Gray T, Topham I, Fone K, Rezvani N, Mee M, Soane T, Layfield R, Sheppard PW, Ebendal T, ... ... Mayer RJ, et al. Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and Lewy-like inclusions resembling human pale bodies. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 8189-98. PMID 18701681 DOI: 10.1523/Jneurosci.2218-08.2008  0.378
2006 Dawson S, Higashitsuji H, Wilkinson AJ, Fujita J, Mayer RJ. Gankyrin: a new oncoprotein and regulator of pRb and p53. Trends in Cell Biology. 16: 229-33. PMID 16581249 DOI: 10.1016/J.Tcb.2006.03.001  0.3
2005 Lowe J, Hand N, Mayer RJ. Application of ubiquitin immunohistochemistry to the diagnosis of disease. Methods in Enzymology. 399: 86-119. PMID 16338351 DOI: 10.1016/S0076-6879(05)99007-1  0.37
2005 Devoy A, Soane T, Welchman R, Mayer RJ. The ubiquitin-proteasome system and cancer. Essays in Biochemistry. 41: 187-203. PMID 16250906 DOI: 10.1042/Eb0410187  0.328
2005 Higashitsuji H, Liu Y, Mayer RJ, Fujita J. The oncoprotein gankyrin negatively regulates both p53 and RB by enhancing proteasomal degradation. Cell Cycle (Georgetown, Tex.). 4: 1335-7. PMID 16177571 DOI: 10.4161/Cc.4.10.2107  0.332
2005 Welchman RL, Gordon C, Mayer RJ. Ubiquitin and ubiquitin-like proteins as multifunctional signals. Nature Reviews. Molecular Cell Biology. 6: 599-609. PMID 16064136 DOI: 10.1038/Nrm1700  0.357
2005 Adori C, Kovács GG, Low P, Molnár K, Gorbea C, Fellinger E, Budka H, Mayer RJ, László L. The ubiquitin-proteasome system in Creutzfeldt-Jakob and Alzheimer disease: intracellular redistribution of components correlates with neuronal vulnerability. Neurobiology of Disease. 19: 427-35. PMID 16023585 DOI: 10.1016/J.Nbd.2005.01.015  0.317
2004 Krzywda S, Brzozowski AM, Higashitsuji H, Fujita J, Welchman R, Dawson S, Mayer RJ, Wilkinson AJ. The crystal structure of gankyrin, an oncoprotein found in complexes with cyclin-dependent kinase 4, a 19 S proteasomal ATPase regulator, and the tumor suppressors Rb and p53. The Journal of Biological Chemistry. 279: 1541-5. PMID 14573599 DOI: 10.1074/Jbc.M310265200  0.36
2002 Doherty FJ, Dawson S, Mayer RJ. The ubiquitin-proteasome pathway of intracellular proteolysis. Essays in Biochemistry. 38: 51-63. PMID 12463161 DOI: 10.1042/Bse0380051  0.386
2001 Kovács GG, Kurucz I, Budka H, Adori C, Müller F, Acs P, Klöppel S, Schätzl HM, Mayer RJ, László L. Prominent stress response of Purkinje cells in Creutzfeldt-Jakob disease. Neurobiology of Disease. 8: 881-9. PMID 11592855 DOI: 10.1006/Nbdi.2001.0418  0.308
2001 Layfield R, Alban A, Mayer RJ, Lowe J. The ubiquitin protein catabolic disorders. Neuropathology and Applied Neurobiology. 27: 171-9. PMID 11489136 DOI: 10.1046/J.1365-2990.2001.00335.X  0.378
2000 Mayer RJ. The meteoric rise of regulated intracellular proteolysis. Nature Reviews. Molecular Cell Biology. 1: 145-8. PMID 11253367 DOI: 10.1038/35040090  0.313
2000 Lam YA, Pickart CM, Alban A, Landon M, Jamieson C, Ramage R, Mayer RJ, Layfield R. Inhibition of the ubiquitin-proteasome system in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 97: 9902-6. PMID 10944193 DOI: 10.1073/Pnas.170173897  0.318
1999 Layfield R, Franklin K, Landon M, Walker G, Wang P, Ramage R, Brown A, Love S, Urquhart K, Muir T, Baker R, Mayer RJ. Chemically synthesized ubiquitin extension proteins detect distinct catalytic capacities of deubiquitinating enzymes. Analytical Biochemistry. 274: 40-9. PMID 10527495 DOI: 10.1006/Abio.1999.4234  0.348
1999 Layfield R, Hayes C, Wang P, Urquhart K, Ramage R, Mayer RJ, Landon M. Electrophoretic separation of ubiquitin and single amino acid residue ubiquitin extensions using a commercial modified acrylamide gel electrophoresis system: an assay to determine catalytic capacities of deubiquitinating enzymes. Electrophoresis. 20: 480-2. PMID 10217157 DOI: 10.1002/(Sici)1522-2683(19990301)20:3<480::Aid-Elps480>3.0.Co;2-N  0.312
1998 Arnold J, Dawson S, Fergusson J, Lowe J, Landon M, Mayer RJ. Ubiquitin and its role in neurodegeneration. Progress in Brain Research. 117: 23-34. PMID 9932397 DOI: 10.1016/S0079-6123(08)64004-2  0.384
1998 Mayer RJ, Landon M, Layfield R. Ubiquitin superfolds: intrinsic and attachable regulators of cellular activities? Folding & Design. 3: R97-9. PMID 9806944 DOI: 10.1016/S1359-0278(98)00047-9  0.362
1997 Layfield R, Bailey K, Dineen R, Mehrotra P, Lowe J, Allibone R, Mayer RJ, Landon M. Application of formalin fixation to the purification of amyloid proteins. Analytical Biochemistry. 253: 142-4. PMID 9356158 DOI: 10.1006/Abio.1997.2370  0.302
1997 Dawson S, Hastings R, Takayanagi K, Reynolds S, Løw P, Billett M, Mayer RJ. The 26S-proteasome: regulation and substrate recognition. Molecular Biology Reports. 24: 39-44. PMID 9228279 DOI: 10.1023/A:1006800522814  0.319
1997 Franklin K, Layfield R, Landon M, Ramage R, Brown A, Love S, Muir T, Urquhart K, Bownes M, Mayer RJ. Capillary electrophoresis assay for ubiquitin carboxyl-terminal hydrolases with chemically synthesized ubiquitin-valine as substrate. Analytical Biochemistry. 247: 305-9. PMID 9177692 DOI: 10.1006/Abio.1997.2099  0.345
1996 Mayer RJ, Tipler C, Arnold J, Laszlo L, Al-Khedhairy A, Lowe J, Landon M. Endosome-lysosomes, ubiquitin and neurodegeneration. Advances in Experimental Medicine and Biology. 389: 261-9. PMID 8861020 DOI: 10.1007/978-1-4613-0335-0_33  0.338
1996 Layfield R, Fergusson J, Aitken A, Lowe J, Landon M, Mayer RJ. Neurofibrillary tangles of Alzheimer's disease brains contain 14-3-3 proteins. Neuroscience Letters. 209: 57-60. PMID 8734909 DOI: 10.1016/0304-3940(96)12598-2  0.327
1995 Löw P, Doherty FJ, Fellinger E, Sass M, Mayer RJ, László L. Related organelles of the endosome-lysosome system contain a different repertoire of ubiquitinated proteins in Sf9 insect cells. Febs Letters. 368: 125-31. PMID 7615065 DOI: 10.1016/0014-5793(95)00624-I  0.347
1993 Löw P, Doherty FJ, Sass M, Kovács J, Mayer RJ, László L. Immunogold localisation of ubiquitin-protein conjugates in Sf9 insect cells. Implications for the biogenesis of lysosome-related organelles. Febs Letters. 316: 152-6. PMID 8380561 DOI: 10.1016/0014-5793(93)81205-E  0.342
1993 Lowe J, Mayer RJ, Landon M. Ubiquitin in neurodegenerative diseases. Brain Pathology (Zurich, Switzerland). 3: 55-65. PMID 8269084 DOI: 10.1111/J.1750-3639.1993.Tb00726.X  0.312
1991 Mayer RJ, Lowe J, Landon M. Ubiquitin and the molecular pathology of chronic degenerative diseases. The Journal of Pathology. 163: 279-81. PMID 1851826 DOI: 10.1002/Path.1711630402  0.343
1991 László L, Doherty FJ, Watson A, Self T, Landon M, Lowe J, Mayer RJ. Immunogold localisation of ubiquitin-protein conjugates in primary (azurophilic) granules of polymorphonuclear neutrophils. Febs Letters. 279: 175-8. PMID 1848188 DOI: 10.1016/0014-5793(91)80142-P  0.321
1991 László L, Tuckwell J, Self T, Lowe J, Landon M, Smith S, Hawthorne JN, Mayer RJ. The latent membrane protein-1 in Epstein-Barr virus-transformed lymphoblastoid cells is found with ubiquitin-protein conjugates and heat-shock protein 70 in lysosomes oriented around the microtubule organizing centre. The Journal of Pathology. 164: 203-14. PMID 1653831 DOI: 10.1002/Path.1711640305  0.326
1991 Scotting P, McDermott H, Mayer RJ. Ubiquitin-protein conjugates and alpha B crystallin are selectively present in cells undergoing major cytomorphological reorganisation in early chicken embryos. Febs Letters. 285: 75-9. PMID 1648516 DOI: 10.1016/0014-5793(91)80728-L  0.338
1991 Mayer RJ, Arnold J, László L, Landon M, Lowe J. Ubiquitin in health and disease. Biochimica Et Biophysica Acta. 1089: 141-57. PMID 1647208 DOI: 10.1016/0167-4781(91)90002-4  0.395
1990 Laszlo L, Doherty FJ, Osborn NU, Mayer RJ. Ubiquitinated protein conjugates are specifically enriched in the lysosomal system of fibroblasts Febs Letters. 261: 365-368. PMID 2155827 DOI: 10.1016/0014-5793(90)80593-8  0.361
1990 Lowe J, McDermott H, Kenward N, Landon M, Mayer RJ, Bruce M, McBride P, Somerville RA, Hope J. Ubiquitin conjugate immunoreactivity in the brains of scrapie infected mice. The Journal of Pathology. 162: 61-6. PMID 1977900 DOI: 10.1002/Path.1711620112  0.347
1988 Lennox G, Lowe J, Morrell K, Landon M, Mayer RJ. Ubiquitin is a component of neurofibrillary tangles in a variety of neurodegenerative diseases. Neuroscience Letters. 94: 211-7. PMID 2853854 DOI: 10.1016/0304-3940(88)90297-2  0.31
1987 Fernig DG, Mayer RJ. Degradation of nuclear proteins: studies on transplanted B82 cell karyoplast proteins Febs Letters. 210: 165-168. PMID 3025024 DOI: 10.1016/0014-5793(87)81329-7  0.523
1986 Mayer RJ, Doherty F. Intracellular protein catabolism: state of the art Febs Letters. 198: 181-193. PMID 3007210 DOI: 10.1016/0014-5793(86)80403-3  0.336
1984 Brookes C, Wright A, Evans PJ, Mayer RJ. Aflatoxin B1: effect on the synthesis and degradation of mitochondrial proteins in hepatocyte monolayers. Carcinogenesis. 5: 759-765. PMID 6144403 DOI: 10.1093/Carcin/5.6.759  0.313
1981 Wilde CJ, Hasan HR, White DA, Mayer RJ. The effect of calcium on synthesis and degradation of mammary cytosolic proteins and casein. Biochemical and Biophysical Research Communications. 103: 934-942. PMID 6800372 DOI: 10.1016/0006-291X(81)90900-1  0.3
1981 Wilde CJ, Mayer RJ. Degradation Of Cytosol-Fraction Proteins In Mammary Gland Explants Biochemical Society Transactions. 9. DOI: 10.1042/Bst009258Pb  0.331
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