| Year |
Citation |
Score |
| 2020 |
Shepherd CE, Affleck AJ, Bahar AY, Carew-Jones F, Gregory G, Small DH, Halliday GM. Alzheimer's amyloid-β and tau protein accumulation is associated with decreased expression of the LDL receptor-associated protein in human brain tissue. Brain and Behavior. e01672. PMID 32484608 DOI: 10.1002/brb3.1672 |
0.457 |
|
| 2020 |
Juliano JP, Small DH, Aguilar MI. Peptidomimetic Modulators of BACE1 Australian Journal of Chemistry. 73: 366-376. DOI: 10.1071/Ch19594 |
0.342 |
|
| 2018 |
Southam KA, Stennard F, Pavez C, Small DH. Knockout of Amyloid β Protein Precursor (APP) Expression Alters Synaptogenesis, Neurite Branching and Axonal Morphology of Hippocampal Neurons. Neurochemical Research. PMID 29572646 DOI: 10.1007/s11064-018-2512-0 |
0.378 |
|
| 2016 |
Cui H, King AE, Jacobson GA, Small DH. Peripheral treatment with enoxaparin exacerbates amyloid plaque pathology in Tg2576 mice. Journal of Neuroscience Research. PMID 27546887 DOI: 10.1002/jnr.23880 |
0.459 |
|
| 2016 |
Smith AI, Rajapakse NW, Kleifeld O, Lomonte B, Sikanyika NL, Spicer AJ, Hodgson WC, Conroy PJ, Small DH, Kaye DM, Parkington HC, Whisstock JC, Kuruppu S. N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and Neprilysin. Scientific Reports. 6: 22413. PMID 26931059 DOI: 10.1038/srep22413 |
0.313 |
|
| 2016 |
Southam KA, Vincent AJ, Small DH. Do Microglia Default on Network Maintenance in Alzheimer's Disease? Journal of Alzheimer's Disease : Jad. PMID 26890782 DOI: 10.3233/JAD-151075 |
0.432 |
|
| 2014 |
Bolós M, Hu Y, Young KM, Foa L, Small DH. Neurogenin 2 mediates amyloid-β precursor protein-stimulated neurogenesis. The Journal of Biological Chemistry. 289: 31253-61. PMID 25217641 DOI: 10.1074/jbc.M114.581918 |
0.388 |
|
| 2014 |
Dawkins E, Gasperini R, Hu Y, Cui H, Vincent AJ, Bolós M, Young KM, Foa L, Small DH. The N-terminal fragment of the β-amyloid precursor protein of Alzheimer's disease (N-APP) binds to phosphoinositide-rich domains on the surface of hippocampal neurons. Journal of Neuroscience Research. 92: 1478-89. PMID 24916405 DOI: 10.1002/jnr.23422 |
0.389 |
|
| 2014 |
Dawkins E, Small DH. Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's disease. Journal of Neurochemistry. 129: 756-69. PMID 24517464 DOI: 10.1111/jnc.12675 |
0.462 |
|
| 2014 |
Small DH, Hu Y, Bolós M, Dawkins E, Foa L, Young KM. β-Amyloid precursor protein: function in stem cell development and Alzheimer's disease brain. Neuro-Degenerative Diseases. 13: 96-8. PMID 23942027 DOI: 10.1159/000353686 |
0.399 |
|
| 2013 |
Hu Y, Hung AC, Cui H, Dawkins E, Bolós M, Foa L, Young KM, Small DH. Role of cystatin C in amyloid precursor protein-induced proliferation of neural stem/progenitor cells. The Journal of Biological Chemistry. 288: 18853-62. PMID 23671283 DOI: 10.1074/jbc.M112.443671 |
0.359 |
|
| 2013 |
Cui H, Freeman C, Jacobson GA, Small DH. Proteoglycans in the central nervous system: role in development, neural repair, and Alzheimer's disease. Iubmb Life. 65: 108-20. PMID 23297096 DOI: 10.1002/iub.1118 |
0.41 |
|
| 2012 |
Gasperini RJ, Klaver DW, Hou X, Aguilar MI, Small DH. Mechanisms of transthyretin aggregation and toxicity. Sub-Cellular Biochemistry. 65: 211-24. PMID 23225005 DOI: 10.1007/978-94-007-5416-4_9 |
0.36 |
|
| 2012 |
Cui H, Hung AC, Freeman C, Narkowicz C, Jacobson GA, Small DH. Size and sulfation are critical for the effect of heparin on APP processing and Aβ production. Journal of Neurochemistry. 123: 447-57. PMID 22909067 DOI: 10.1111/j.1471-4159.2012.07929.x |
0.41 |
|
| 2012 |
Zhai J, Lee TH, Small DH, Aguilar MI. Characterization of early stage intermediates in the nucleation phase of Aβ aggregation. Biochemistry. 51: 1070-8. PMID 22283417 DOI: 10.1021/bi201871r |
0.4 |
|
| 2012 |
Gasperini RJ, Small DH. Neurodegeneration in familial amyloidotic polyneuropathy. Clinical and Experimental Pharmacology & Physiology. 39: 680-3. PMID 21916933 DOI: 10.1111/j.1440-1681.2011.05607.x |
0.343 |
|
| 2012 |
Silveyra MX, GarcÃa-Ayllón MS, de Barreda EG, Small DH, MartÃnez S, Avila J, Sáez-Valero J. Altered expression of brain acetylcholinesterase in FTDP-17 human tau transgenic mice. Neurobiology of Aging. 33: 624.e23-34. PMID 21530001 DOI: 10.1016/j.neurobiolaging.2011.03.006 |
0.371 |
|
| 2011 |
García-Ayllón MS, Small DH, Avila J, Sáez-Valero J. Revisiting the Role of Acetylcholinesterase in Alzheimer's Disease: Cross-Talk with P-tau and β-Amyloid. Frontiers in Molecular Neuroscience. 4: 22. PMID 21949503 DOI: 10.3389/fnmol.2011.00022 |
0.455 |
|
| 2011 |
Cui H, Hung AC, Klaver DW, Suzuki T, Freeman C, Narkowicz C, Jacobson GA, Small DH. Effects of heparin and enoxaparin on APP processing and Aβ production in primary cortical neurons from Tg2576 mice. Plos One. 6: e23007. PMID 21829577 DOI: 10.1371/Journal.Pone.0023007 |
0.439 |
|
| 2010 |
Vincent AJ, Gasperini R, Foa L, Small DH. Astrocytes in Alzheimer's disease: emerging roles in calcium dysregulation and synaptic plasticity. Journal of Alzheimer's Disease : Jad. 22: 699-714. PMID 20847426 DOI: 10.3233/JAD-2010-101089 |
0.385 |
|
| 2010 |
Klaver DW, Wilce MC, Cui H, Hung AC, Gasperini R, Foa L, Small DH. Is BACE1 a suitable therapeutic target for the treatment of Alzheimer's disease? Current strategies and future directions. Biological Chemistry. 391: 849-59. PMID 20731541 DOI: 10.1515/BC.2010.089 |
0.494 |
|
| 2010 |
Liu SJ, Gasperini R, Foa L, Small DH. Amyloid-beta decreases cell-surface AMPA receptors by increasing intracellular calcium and phosphorylation of GluR2. Journal of Alzheimer's Disease : Jad. 21: 655-66. PMID 20571220 DOI: 10.3233/JAD-2010-091654 |
0.371 |
|
| 2010 |
Klaver D, Hung AC, Gasperini R, Foa L, Aguilar MI, Small DH. Effect of heparin on APP metabolism and Abeta production in cortical neurons. Neuro-Degenerative Diseases. 7: 187-9. PMID 20224283 DOI: 10.1159/000295661 |
0.463 |
|
| 2010 |
Hou X, Small DH, Aguilar MI. Surface plasmon resonance spectroscopy in determination of the interactions between amyloid beta proteins (Abeta) and lipid membranes. Methods in Molecular Biology (Clifton, N.J.). 627: 225-35. PMID 20217625 DOI: 10.1007/978-1-60761-670-2_15 |
0.365 |
|
| 2010 |
Small DH, Klaver DW, Foa L. Presenilins and the gamma-secretase: still a complex problem. Molecular Brain. 3: 7. PMID 20181106 DOI: 10.1186/1756-6606-3-7 |
0.417 |
|
| 2010 |
Klaver DW, Wilce MC, Gasperini R, Freeman C, Juliano JP, Parish C, Foa L, Aguilar MI, Small DH. Glycosaminoglycan-induced activation of the beta-secretase (BACE1) of Alzheimer's disease. Journal of Neurochemistry. 112: 1552-61. PMID 20067575 DOI: 10.1111/j.1471-4159.2010.06571.x |
0.389 |
|
| 2010 |
Kerr ML, Gasperini R, Gibbs ME, Hou X, Shepherd CE, Strickland DK, Foa L, Lawen A, Small DH. Inhibition of Abeta aggregation and neurotoxicity by the 39-kDa receptor-associated protein. Journal of Neurochemistry. 112: 1199-209. PMID 20002523 DOI: 10.1111/J.1471-4159.2009.06540.X |
0.482 |
|
| 2010 |
Gibbs ME, Maksel D, Gibbs Z, Hou X, Summers RJ, Small DH. Memory loss caused by beta-amyloid protein is rescued by a beta(3)-adrenoceptor agonist. Neurobiology of Aging. 31: 614-24. PMID 18632189 DOI: 10.1016/j.neurobiolaging.2008.05.018 |
0.41 |
|
| 2009 |
Beckman M, Freeman C, Parish CR, Small DH. Activation of cathepsin D by glycosaminoglycans. The Febs Journal. 276: 7343-52. PMID 19919557 DOI: 10.1111/j.1742-4658.2009.07444.x |
0.31 |
|
| 2009 |
Small DH. Dysregulation of calcium homeostasis in Alzheimer's disease. Neurochemical Research. 34: 1824-9. PMID 19337829 DOI: 10.1007/s11064-009-9960-5 |
0.404 |
|
| 2009 |
Small DH, Gasperini R, Vincent AJ, Hung AC, Foa L. The role of Abeta-induced calcium dysregulation in the pathogenesis of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 16: 225-33. PMID 19221414 DOI: 10.3233/JAD-2009-0951 |
0.442 |
|
| 2008 |
Small DH, Klaver DW, Beckman M. Regulation of proBACE1 by glycosaminoglycans. Neuro-Degenerative Diseases. 5: 206-8. PMID 18322391 DOI: 10.1159/000113703 |
0.372 |
|
| 2008 |
Small DH. Network dysfunction in Alzheimer's disease: does synaptic scaling drive disease progression? Trends in Molecular Medicine. 14: 103-8. PMID 18262842 DOI: 10.1016/j.molmed.2007.12.006 |
0.428 |
|
| 2008 |
Petratos S, Li QX, George AJ, Hou X, Kerr ML, Unabia SE, Hatzinisiriou I, Maksel D, Aguilar MI, Small DH. The beta-amyloid protein of Alzheimer's disease increases neuronal CRMP-2 phosphorylation by a Rho-GTP mechanism. Brain : a Journal of Neurology. 131: 90-108. PMID 18000012 DOI: 10.1093/brain/awm260 |
0.481 |
|
| 2007 |
Small DH. Neural network dysfunction in Alzheimer's disease: a drug development perspective. Drug News & Perspectives. 20: 557-63. PMID 18176660 DOI: 10.1358/dnp.2007.20.9.1162245 |
0.401 |
|
| 2007 |
Hou X, Aguilar MI, Small DH. Transthyretin and familial amyloidotic polyneuropathy. Recent progress in understanding the molecular mechanism of neurodegeneration. The Febs Journal. 274: 1637-50. PMID 17381508 DOI: 10.1111/j.1742-4658.2007.05712.x |
0.394 |
|
| 2007 |
Small DH, Maksel D, Kerr ML, Ng J, Hou X, Chu C, Mehrani H, Unabia S, Azari MF, Loiacono R, Aguilar MI, Chebib M. The beta-amyloid protein of Alzheimer's disease binds to membrane lipids but does not bind to the alpha7 nicotinic acetylcholine receptor. Journal of Neurochemistry. 101: 1527-38. PMID 17286584 DOI: 10.1111/j.1471-4159.2006.04444.x |
0.462 |
|
| 2007 |
Ng J, Aguilar MI, Small DH. Amyloid toxicity, synaptic dysfunction, and the biochemistry of neurodegeneration in alzheimer's disease Abeta Peptide and Alzheimer's Disease: Celebrating a Century of Research. 93-101. DOI: 10.1007/978-1-84628-440-3_6 |
0.305 |
|
| 2007 |
Small DH, Barrow CJ. A brief introduction to the history of the β-amyloid protein (aβ) of alzheimer's disease Abeta Peptide and Alzheimer's Disease: Celebrating a Century of Research. 1-4. DOI: 10.1007/978-1-84628-440-3_1 |
0.323 |
|
| 2006 |
Small DH, Cappai R. Alois Alzheimer and Alzheimer's disease: a centennial perspective. Journal of Neurochemistry. 99: 708-10. PMID 17076655 DOI: 10.1111/j.1471-4159.2006.04212.x |
0.466 |
|
| 2006 |
Losic D, Martin LL, Aguilar MI, Small DH. Beta-amyloid fibril formation is promoted by step edges of highly oriented pyrolytic graphite. Biopolymers. 84: 519-26. PMID 16752395 DOI: 10.1002/Bip.20549 |
0.428 |
|
| 2006 |
Beckman M, Holsinger RM, Small DH. Heparin activates beta-secretase (BACE1) of Alzheimer's disease and increases autocatalysis of the enzyme. Biochemistry. 45: 6703-14. PMID 16716081 DOI: 10.1021/bi052498t |
0.436 |
|
| 2006 |
Losic D, Martin LL, Mechler A, Aguilar MI, Small DH. High resolution scanning tunnelling microscopy of the beta-amyloid protein (Abeta1-40) of Alzheimer's disease suggests a novel mechanism of oligomer assembly. Journal of Structural Biology. 155: 104-10. PMID 16650774 DOI: 10.1016/J.Jsb.2006.02.013 |
0.446 |
|
| 2006 |
Mok SS, Losic D, Barrow CJ, Turner BJ, Masters CL, Martin LL, Small DH. The beta-amyloid peptide of Alzheimer's disease decreases adhesion of vascular smooth muscle cells to the basement membrane. Journal of Neurochemistry. 96: 53-64. PMID 16269005 DOI: 10.1111/J.1471-4159.2005.03539.X |
0.431 |
|
| 2006 |
Small DH, Holsinger RD, Beckman M. P3-239: Heparin activates βeta-secretase(BACE1) of Alzheimer’s disease and increases autocatalysis of the enzyme Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.1508 |
0.318 |
|
| 2005 |
Small DH. Acetylcholinesterase inhibitors for the treatment of dementia in Alzheimer's disease: do we need new inhibitors? Expert Opinion On Emerging Drugs. 10: 817-25. PMID 16262564 DOI: 10.1517/14728214.10.4.817 |
0.358 |
|
| 2005 |
Hou X, Richardson SJ, Aguilar MI, Small DH. Binding of amyloidogenic transthyretin to the plasma membrane alters membrane fluidity and induces neurotoxicity. Biochemistry. 44: 11618-27. PMID 16114899 DOI: 10.1021/bi050700m |
0.32 |
|
| 2005 |
Kerr ML, Small DH. Cytoplasmic domain of the beta-amyloid protein precursor of Alzheimer's disease: function, regulation of proteolysis, and implications for drug development. Journal of Neuroscience Research. 80: 151-9. PMID 15672415 DOI: 10.1002/jnr.20408 |
0.483 |
|
| 2005 |
Aguilar MI, Small DH. Surface plasmon resonance for the analysis of beta-amyloid interactions and fibril formation in Alzheimer's disease research. Neurotoxicity Research. 7: 17-27. PMID 15639795 DOI: 10.1007/BF03033773 |
0.481 |
|
| 2004 |
Small DH. Mechanisms of synaptic homeostasis in Alzheimer's disease. Current Alzheimer Research. 1: 27-32. PMID 15975082 DOI: 10.2174/1567205043480573 |
0.405 |
|
| 2004 |
Small DH, Losic D, Martin LL, Turner BJ, Friedhuber A, Aguilar MI. Alzheimer's disease therapeutics: new approaches to an ageing problem. Iubmb Life. 56: 203-8. PMID 15230347 DOI: 10.1080/15216540410001709211 |
0.487 |
|
| 2004 |
Small DH. Do acetylcholinesterase inhibitors boost synaptic scaling in Alzheimer's disease? Trends in Neurosciences. 27: 245-9. PMID 15111005 DOI: 10.1016/j.tins.2004.03.006 |
0.363 |
|
| 2004 |
Fodero LR, Mok SS, Losic D, Martin LL, Aguilar MI, Barrow CJ, Livett BG, Small DH. Alpha7-nicotinic acetylcholine receptors mediate an Abeta(1-42)-induced increase in the level of acetylcholinesterase in primary cortical neurones. Journal of Neurochemistry. 88: 1186-93. PMID 15009674 DOI: 10.1046/J.1471-4159.2003.02296.X |
0.441 |
|
| 2003 |
Klug GM, Losic D, Subasinghe SS, Aguilar MI, Martin LL, Small DH. Beta-amyloid protein oligomers induced by metal ions and acid pH are distinct from those generated by slow spontaneous ageing at neutral pH. European Journal of Biochemistry / Febs. 270: 4282-93. PMID 14622293 DOI: 10.1046/J.1432-1033.2003.03815.X |
0.377 |
|
| 2003 |
Nunan J, Williamson NA, Hill AF, Sernee MF, Masters CL, Small DH. Proteasome-mediated degradation of the C-terminus of the Alzheimer's disease beta-amyloid protein precursor: effect of C-terminal truncation on production of beta-amyloid protein. Journal of Neuroscience Research. 74: 378-85. PMID 14598314 DOI: 10.1002/Jnr.10646 |
0.466 |
|
| 2003 |
Sáez-Valero J, Fodero LR, Sjögren M, Andreasen N, Amici S, Gallai V, Vanderstichele H, Vanmechelen E, Parnetti L, Blennow K, Small DH. Glycosylation of acetylcholinesterase and butyrylcholinesterase changes as a function of the duration of Alzheimer's disease. Journal of Neuroscience Research. 72: 520-6. PMID 12704813 DOI: 10.1002/jnr.10599 |
0.443 |
|
| 2003 |
Sáez-Valero J, Fodero LR, White AR, Barrow CJ, Small DH. Acetylcholinesterase is increased in mouse neuronal and astrocyte cultures after treatment with beta-amyloid peptides. Brain Research. 965: 283-6. PMID 12591148 DOI: 10.1016/S0006-8993(02)04159-8 |
0.474 |
|
| 2003 |
Subasinghe S, Unabia S, Barrow CJ, Mok SS, Aguilar MI, Small DH. Cholesterol is necessary both for the toxic effect of Abeta peptides on vascular smooth muscle cells and for Abeta binding to vascular smooth muscle cell membranes. Journal of Neurochemistry. 84: 471-9. PMID 12558967 DOI: 10.1046/j.1471-4159.2003.01552.x |
0.389 |
|
| 2003 |
Small DH, Fodero LR, Losic D, Chu C, Aguilar MI, Martin LL, Chebib M. Role of Aβ and the α7 nicotinic acetylcholine receptor in regulating synaptic plasticity in Alzheimer's disease Letters in Peptide Science. 10: 401-404. DOI: 10.1007/S10989-004-2390-Y |
0.344 |
|
| 2002 |
Nunan J, Small DH. Proteolytic processing of the amyloid-beta protein precursor of Alzheimer's disease. Essays in Biochemistry. 38: 37-49. PMID 12463160 DOI: 10.1042/Bse0380037 |
0.456 |
|
| 2002 |
Small DH, Fodero LR. Cholinergic regulation of synaptic plasticity as a therapeutic target in Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 4: 349-55. PMID 12446967 DOI: 10.3233/Jad-2002-4502 |
0.454 |
|
| 2002 |
Small DH. Is gamma-secretase a multienzyme complex for membrane protein degradation? Models and speculations. Peptides. 23: 1317-21. PMID 12128088 DOI: 10.1016/S0196-9781(02)00072-4 |
0.398 |
|
| 2002 |
Mok SS, Turner BJ, Beyreuther K, Masters CL, Barrow CJ, Small DH. Toxicity of substrate-bound amyloid peptides on vascular smooth muscle cells is enhanced by homocysteine. European Journal of Biochemistry / Febs. 269: 3014-22. PMID 12071966 DOI: 10.1046/J.1432-1033.2002.02976.X |
0.445 |
|
| 2002 |
Fodero LR, Sáez-Valero J, McLean CA, Martins RN, Beyreuther K, Masters CL, Robertson TA, Small DH. Altered glycosylation of acetylcholinesterase in APP (SW) Tg2576 transgenic mice occurs prior to amyloid plaque deposition. Journal of Neurochemistry. 81: 441-8. PMID 12065653 DOI: 10.1046/J.1471-4159.2002.00902.X |
0.385 |
|
| 2002 |
Sáez-Valero J, de Ceballos ML, Small DH, de Felipe C. Changes in molecular isoform distribution of acetylcholinesterase in rat cortex and cerebrospinal fluid after intracerebroventricular administration of amyloid beta-peptide. Neuroscience Letters. 325: 199-202. PMID 12044655 DOI: 10.1016/S0304-3940(02)00282-3 |
0.401 |
|
| 2002 |
Small DH. Alzheimer's disease biomarkers: their value in diagnosis and clinical trials. Frontiers in Bioscience : a Journal and Virtual Library. 7: d986-8. PMID 11897567 DOI: 10.2741/Small |
0.351 |
|
| 2002 |
Small D. Alzheimer's and Parkinson's Diseases: Recent Developments (Advances in Behavioral Biology, Volume 44), edited by Israel Hanin, Mitsuo Yoshida, and Abraham Fisher. Plenum Press, New York, 1993, ISBN 0‐306‐45004‐6, 724 + xx pp., $149.00. Journal of Neurochemistry. 66: 438-438. DOI: 10.1046/J.1471-4159.1996.66010438.X |
0.316 |
|
| 2002 |
Fodero LR, Small DH. Cholinergic abnormalities in Alzheimer's disease: Are there new targets for drug development? Drug Development Research. 56: 369-379. DOI: 10.1002/ddr.10089 |
0.387 |
|
| 2001 |
Sáez-Valero J, Small DH. Acetylcholinesterase and butyrylcholinesterase glycoforms are biomarkers of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 3: 323-328. PMID 12214053 DOI: 10.3233/Jad-2001-3307 |
0.424 |
|
| 2001 |
Small DH. Biomarkers of Alzheimer's disease: Bridging the gap between basic science and clinical practice. Journal of Alzheimer's Disease : Jad. 3: 257-259. PMID 12214047 DOI: 10.3233/Jad-2001-3301 |
0.338 |
|
| 2001 |
Fodero LR, Sáez-Valero J, Barquero MS, Marcos A, McLean CA, Small DH. Wheat germ agglutinin-binding glycoproteins are decreased in Alzheimer's disease cerebrospinal fluid. Journal of Neurochemistry. 79: 1022-6. PMID 11739614 DOI: 10.1046/J.1471-4159.2001.00640.X |
0.416 |
|
| 2001 |
Nunan J, Shearman MS, Checler F, Cappai R, Evin G, Beyreuther K, Masters CL, Small DH. The C-terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome-dependent mechanism distinct from gamma-secretase. European Journal of Biochemistry / Febs. 268: 5329-36. PMID 11606195 DOI: 10.1046/J.0014-2956.2001.02465.X |
0.481 |
|
| 2001 |
Small DH, Mok SS, Bornstein JC. Alzheimer's disease and Abeta toxicity: from top to bottom. Nature Reviews. Neuroscience. 2: 595-8. PMID 11484003 DOI: 10.1038/35086072 |
0.394 |
|
| 2001 |
Sáez-Valero J, Small DH. Altered glycosylation of cerebrospinal fluid butyrylcholinesterase in Alzheimer's disease. Brain Research. 889: 247-50. PMID 11166713 DOI: 10.1016/S0006-8993(00)03144-9 |
0.406 |
|
| 2000 |
Sáez-Valero J, Mok SS, Small DH. An unusually glycosylated form of acetylcholinesterase is a CSF biomarker for Alzheimer's disease. Acta Neurologica Scandinavica. Supplementum. 176: 49-52. PMID 11261805 DOI: 10.1034/J.1600-0404.2000.00307.X |
0.429 |
|
| 2000 |
Nunan J, Small DH. Regulation of APP cleavage by alpha-, beta- and gamma-secretases. Febs Letters. 483: 6-10. PMID 11033346 DOI: 10.1016/S0014-5793(00)02076-7 |
0.432 |
|
| 2000 |
Sáez-Valero J, Barquero MS, Marcos A, McLean CA, Small DH. Altered glycosylation of acetylcholinesterase in lumbar cerebrospinal fluid of patients with Alzheimer's disease. Journal of Neurology, Neurosurgery, and Psychiatry. 69: 664-7. PMID 11032625 DOI: 10.1136/Jnnp.69.5.664 |
0.407 |
|
| 2000 |
Mok SS, Clippingdale AB, Beyreuther K, Masters CL, Barrow CJ, Small DH. A beta peptides and calcium influence secretion of the amyloid protein precursor from chick sympathetic neurons in culture. Journal of Neuroscience Research. 61: 449-57. PMID 10931532 DOI: 10.1002/1097-4547(20000815)61:4<449::Aid-Jnr12>3.0.Co;2-N |
0.401 |
|
| 2000 |
Postuma RB, He W, Nunan J, Beyreuther K, Masters CL, Barrow CJ, Small DH. Substrate-bound beta-amyloid peptides inhibit cell adhesion and neurite outgrowth in primary neuronal cultures. Journal of Neurochemistry. 74: 1122-30. PMID 10693944 DOI: 10.1046/J.1471-4159.2000.741122.X |
0.461 |
|
| 2000 |
Saez-Valero J, Mok SS, Barquero M, Marcos A, Small DH. A novel isoform of acetylcholinesterase (ACHEAD) in cerebrospinal fluid is a potential diagnostic marker for Alzheimer disease that is not altered in other neurological diseases Neurobiology of Aging. 21: 272. DOI: 10.1016/S0197-4580(00)83177-2 |
0.345 |
|
| 2000 |
Mok SS, Clippingdale AB, Barrow CJ, Small DH. Amyloid protein precursor secretion by chick sympathetic neurons is inhibited by Aβ peptides Neurobiology of Aging. 21: 145. DOI: 10.1016/S0197-4580(00)82452-5 |
0.418 |
|
| 1999 |
Small DH, Clarris HL, Williamson TG, Reed G, Key B, Mok SS, Beyreuther K, Masters CL, Nurcombe V. Neurite-outgrowth regulating functions of the amyloid protein precursor of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 1: 275-85. PMID 12214125 DOI: 10.3233/Jad-1999-14-508 |
0.425 |
|
| 1999 |
Caswell MD, Mok SS, Henry A, Cappai R, Klug G, Beyreuther K, Masters CL, Small DH. The amyloid beta-protein precursor of Alzheimer's disease is degraded extracellularly by a Kunitz protease inhibitor domain-sensitive trypsin-like serine protease in cultures of chick sympathetic neurons. European Journal of Biochemistry / Febs. 266: 509-16. PMID 10561592 DOI: 10.1046/J.1432-1327.1999.00886.X |
0.488 |
|
| 1999 |
Small DH, McLean CA. Alzheimer's disease and the amyloid beta protein: What is the role of amyloid? Journal of Neurochemistry. 73: 443-9. PMID 10428038 DOI: 10.1046/J.1471-4159.1999.0730443.X |
0.366 |
|
| 1999 |
Postuma RB, Sáez-Valero J, Small DH. Inhibition of neurite outgrowth from chick sympathetic neurons by cholinesterase inhibitors is not mediated by binding to cholinesterases. Neuroscience Letters. 266: 77-80. PMID 10353331 DOI: 10.1016/S0304-3940(99)00266-9 |
0.321 |
|
| 1999 |
Yang DS, Small DH, Seydel U, Smith JD, Hallmayer J, Gandy SE, Martins RN. Apolipoprotein E promotes the binding and uptake of beta-amyloid into Chinese hamster ovary cells in an isoform-specific manner. Neuroscience. 90: 1217-26. PMID 10338292 DOI: 10.1016/S0306-4522(98)00561-2 |
0.346 |
|
| 1999 |
Sáez-Valero J, Sberna G, McLean CA, Small DH. Molecular isoform distribution and glycosylation of acetylcholinesterase are altered in brain and cerebrospinal fluid of patients with Alzheimer's disease. Journal of Neurochemistry. 72: 1600-8. PMID 10098867 DOI: 10.1046/J.1471-4159.1999.721600.X |
0.416 |
|
| 1999 |
Cappai R, Mok SS, Galatis D, Tucker DF, Henry A, Beyreuther K, Small DH, Masters CL. Recombinant human amyloid precursor-like protein 2 (APLP2) expressed in the yeast Pichia pastoris can stimulate neurite outgrowth. Febs Letters. 442: 95-8. PMID 9923612 DOI: 10.1016/S0014-5793(98)01635-4 |
0.435 |
|
| 1998 |
Small DH. The Sixth International Conference on Alzheimer's disease, Amsterdam, The Netherlands, July 1998. The amyloid cascade hypothesis debate: emerging consensus on the role of A beta and amyloid in Alzheimer's disease. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 5: 301-4. PMID 10036589 DOI: 10.3109/13506129809007304 |
0.456 |
|
| 1998 |
Sberna G, Sáez-Valero J, Li QX, Czech C, Beyreuther K, Masters CL, McLean CA, Small DH. Acetylcholinesterase is increased in the brains of transgenic mice expressing the C-terminal fragment (CT100) of the beta-amyloid protein precursor of Alzheimer's disease. Journal of Neurochemistry. 71: 723-31. PMID 9681463 DOI: 10.1046/J.1471-4159.1998.71020723.X |
0.435 |
|
| 1998 |
Postuma RB, Martins RN, Cappai R, Beyreuther K, Masters CL, Strickland DK, Mok SS, Small DH. Effects of the amyloid protein precursor of Alzheimer's disease and other ligands of the LDL receptor-related protein on neurite outgrowth from sympathetic neurons in culture. Febs Letters. 428: 13-6. PMID 9645465 DOI: 10.1016/S0014-5793(98)00475-X |
0.466 |
|
| 1998 |
Small DH. The role of the amyloid protein precursor (APP) in Alzheimer's disease: does the normal function of APP explain the topography of neurodegeneration? Neurochemical Research. 23: 795-806. PMID 9566620 DOI: 10.1023/A:1022471729291 |
0.482 |
|
| 1998 |
Moir RD, Lynch T, Bush AI, Whyte S, Henry A, Portbury S, Multhaup G, Small DH, Tanzi RE, Beyreuther K, Masters CL. Relative increase in Alzheimer's disease of soluble forms of cerebral Abeta amyloid protein precursor containing the Kunitz protease inhibitory domain. The Journal of Biological Chemistry. 273: 5013-9. PMID 9478949 DOI: 10.1074/Jbc.273.9.5013 |
0.475 |
|
| 1997 |
Mok SS, Sberna G, Heffernan D, Cappai R, Galatis D, Clarris HJ, Sawyer WH, Beyreuther K, Masters CL, Small DH. Expression and analysis of heparin-binding regions of the amyloid precursor protein of Alzheimer's disease. Febs Letters. 415: 303-7. PMID 9357988 DOI: 10.1016/S0014-5793(97)01146-0 |
0.376 |
|
| 1997 |
Sáez-Valero J, Sberna G, McLean CA, Masters CL, Small DH. Glycosylation of acetylcholinesterase as diagnostic marker for Alzheimer's disease. Lancet (London, England). 350: 929. PMID 9314873 DOI: 10.1016/S0140-6736(97)24039-0 |
0.427 |
|
| 1997 |
Sberna G, Sáez-Valero J, Beyreuther K, Masters CL, Small DH. The amyloid beta-protein of Alzheimer's disease increases acetylcholinesterase expression by increasing intracellular calcium in embryonal carcinoma P19 cells. Journal of Neurochemistry. 69: 1177-84. PMID 9282941 DOI: 10.1046/J.1471-4159.1997.69031177.X |
0.409 |
|
| 1997 |
Clarris HJ, Cappai R, Heffernan D, Beyreuther K, Masters CL, Small DH. Identification of heparin-binding domains in the amyloid precursor protein of Alzheimer's disease by deletion mutagenesis and peptide mapping. Journal of Neurochemistry. 68: 1164-72. PMID 9048763 DOI: 10.1046/J.1471-4159.1997.68031164.X |
0.383 |
|
| 1997 |
Mok SS, Evin G, Li QX, Smith AI, Beyreuther K, Masters CL, Small DH. A novel metalloprotease in rat brain cleaves the amyloid precursor protein of Alzheimer's disease generating amyloidogenic fragments. Biochemistry. 36: 156-63. PMID 8993329 DOI: 10.1021/Bi961848W |
0.46 |
|
| 1996 |
Williamson TG, Mok SS, Henry A, Cappai R, Lander AD, Nurcombe V, Beyreuther K, Masters CL, Small DH. Secreted glypican binds to the amyloid precursor protein of Alzheimer's disease (APP) and inhibits APP-induced neurite outgrowth. The Journal of Biological Chemistry. 271: 31215-21. PMID 8940123 DOI: 10.1074/Jbc.271.49.31215 |
0.495 |
|
| 1996 |
Small DH, Michaelson S, Sberna G. Non-classical actions of cholinesterases: role in cellular differentiation, tumorigenesis and Alzheimer's disease. Neurochemistry International. 28: 453-83. PMID 8792327 DOI: 10.1016/0197-0186(95)00099-2 |
0.421 |
|
| 1996 |
Beyreuther K, Multhaup G, Mönning U, Sandbrink R, Beher D, Hesse L, Small DH, Masters CL. Regulation of APP expression, biogenesis and metabolism by extracellular matrix and cytokines. Annals of the New York Academy of Sciences. 777: 74-6. PMID 8624129 DOI: 10.1111/J.1749-6632.1996.Tb34403.X |
0.414 |
|
| 1996 |
Small DH, Williamson T, Reed G, Clarris H, Beyreuther K, Masters CL, Nurcombe V. The role of heparan sulfate proteoglycans in the pathogenesis of Alzheimer's disease. Annals of the New York Academy of Sciences. 777: 316-21. PMID 8624106 DOI: 10.1111/J.1749-6632.1996.Tb34439.X |
0.524 |
|
| 1996 |
Williamson TG, Mok SS, Cappai R, Henry A, Bevreuther K, Masters CL, Small DH. 325 Glypican purified from PC12 cells binds to APP and inhibits APP-induced neurite outgrowth Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80327-7 |
0.382 |
|
| 1996 |
Small D, Clarris H, Williamson T, Beyreuther K, Masters C, Nurcombe V. 74 Binding of APP to extracellular matrix proteoglycans stimulates neurite outgrowth Neurobiology of Aging. 17: S19. DOI: 10.1016/S0197-4580(96)80076-5 |
0.309 |
|
| 1995 |
LePage RN, Fosang AJ, Fuller SJ, Murphy G, Evin G, Beyreuther K, Masters CL, Small DH. Gelatinase A possesses a beta-secretase-like activity in cleaving the amyloid protein precursor of Alzheimer's disease. Febs Letters. 377: 267-70. PMID 8543065 DOI: 10.1016/0014-5793(95)01358-X |
0.435 |
|
| 1995 |
Small DH, Reed G, Whitefield B, Nurcombe V. Cholinergic regulation of neurite outgrowth from isolated chick sympathetic neurons in culture. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 144-51. PMID 7823125 DOI: 10.1523/Jneurosci.15-01-00144.1995 |
0.318 |
|
| 1995 |
Li QX, Evin G, Small DH, Multhaup G, Beyreuther K, Masters CL. Proteolytic processing of Alzheimer's disease beta A4 amyloid precursor protein in human platelets. The Journal of Biological Chemistry. 270: 14140-7. PMID 7775475 DOI: 10.1074/Jbc.270.23.14140 |
0.401 |
|
| 1995 |
Williamson TG, Nurcombe V, Beyreuther K, Masters CL, Small DH. Affinity purification of proteoglycans that bind to the amyloid protein precursor of Alzheimer's disease. Journal of Neurochemistry. 65: 2201-8. PMID 7595508 DOI: 10.1046/J.1471-4159.1995.65052201.X |
0.428 |
|
| 1995 |
Evin G, Cappai R, Li QX, Culvenor JG, Small DH, Beyreuther K, Masters CL. Candidate gamma-secretases in the generation of the carboxyl terminus of the Alzheimer's disease beta A4 amyloid: possible involvement of cathepsin D. Biochemistry. 34: 14185-92. PMID 7578016 DOI: 10.1021/Bi00043A024 |
0.454 |
|
| 1995 |
Clarris HJ, Key B, Beyreuther K, Masters CL, Small DH. Expression of the amyloid protein precursor of Alzheimer's disease in the developing rat olfactory system. Brain Research. Developmental Brain Research. 88: 87-95. PMID 7493410 DOI: 10.1016/0165-3806(95)00083-P |
0.334 |
|
| 1995 |
Small DH, Reed G, Fuller SJ, Masters CL, Weidemann A, Beyreuther K. [18] Proteolytic processing of amyloid protein precursor of Alzheimer's disease Methods in Neurosciences. 23: 317-327. DOI: 10.1016/S1043-9471(06)80129-1 |
0.431 |
|
| 1994 |
Small DH, Nurcombe V, Reed G, Clarris H, Moir R, Beyreuther K, Masters CL. A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 2117-27. PMID 8158260 DOI: 10.1523/Jneurosci.14-04-02117.1994 |
0.449 |
|
| 1994 |
Clarris HJ, Nurcombe V, Small DH, Beyreuther K, Masters CL. Secretion of nerve growth factor from septum stimulates neurite outgrowth and release of the amyloid protein precursor of Alzheimer's disease from hippocampal explants. Journal of Neuroscience Research. 38: 248-58. PMID 7932862 DOI: 10.1002/Jnr.490380303 |
0.44 |
|
| 1993 |
Michaelson S, Small DH. A protease is recovered with a dimeric form of acetylcholinesterase in fetal bovine serum. Brain Research. 611: 75-80. PMID 8518952 DOI: 10.1016/0006-8993(93)91779-R |
0.339 |
|
| 1993 |
Bush AI, Multhaup G, Moir RD, Williamson TG, Small DH, Rumble B, Pollwein P, Beyreuther K, Masters CL. A novel zinc(II) binding site modulates the function of the beta A4 amyloid protein precursor of Alzheimer's disease. The Journal of Biological Chemistry. 268: 16109-12. PMID 8344894 |
0.337 |
|
| 1993 |
Small DH, Nurcombe V, Clarris H, Beyreuther K, Masters CL. The role of extracellular matrix in the processing of the amyloid protein precursor of Alzheimer's disease. Annals of the New York Academy of Sciences. 695: 169-74. PMID 8239278 DOI: 10.1111/J.1749-6632.1993.Tb23047.X |
0.514 |
|
| 1993 |
Cheung NS, Small DH, Livett BG. An amyloid peptide, beta A4 25-35, mimics the function of substance P on modulation of nicotine-evoked secretion and desensitization in cultured bovine adrenal chromaffin cells. Journal of Neurochemistry. 60: 1163-6. PMID 7679724 DOI: 10.1111/J.1471-4159.1993.Tb03270.X |
0.333 |
|
| 1992 |
Bush AI, Whyte S, Thomas LD, Williamson TG, Van Tiggelen CJ, Currie J, Small DH, Moir RD, Li QX, Rumble B. An abnormality of plasma amyloid protein precursor in Alzheimer's disease. Annals of Neurology. 32: 57-65. PMID 1642473 DOI: 10.1002/Ana.410320110 |
0.454 |
|
| 1992 |
Milward EA, Papadopoulos R, Fuller SJ, Moir RD, Small D, Beyreuther K, Masters CL. The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth. Neuron. 9: 129-37. PMID 1632967 DOI: 10.1016/0896-6273(92)90228-6 |
0.462 |
|
| 1992 |
Moir RD, Martins RN, Bush AI, Small DH, Milward EA, Rumble BA, Multhaup G, Beyreuther K, Masters CL. Human brain beta A4 amyloid protein precursor of Alzheimer's disease: purification and partial characterization. Journal of Neurochemistry. 59: 1490-8. PMID 1402900 DOI: 10.1111/J.1471-4159.1992.Tb08465.X |
0.46 |
|
| 1992 |
Small DH, Nurcombe V, Moir R, Michaelson S, Monard D, Beyreuther K, Masters CL. Association and release of the amyloid protein precursor of Alzheimer's disease from chick brain extracellular matrix. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 12: 4143-50. PMID 1279136 DOI: 10.1523/Jneurosci.12-11-04143.1992 |
0.446 |
|
| 1992 |
Rumble B, Small D, Moir R, Bush A, Masters C, Beyreuther K. Plasma kallikrein may process the amyloid protein precursor of alzheimer’s disease Pathology. 24: 24. DOI: 10.1016/S0031-3025(16)35968-2 |
0.447 |
|
| 1992 |
Whyte S, Bush AI, Currie J, Williamson TG, Tiggelen CJV, Small DH, Moir RD, Rumble B, Thomas LD, Li Q, Mönning U, Beyreuther K, Masters CL. The abnormality of plasma amyloid protein precursor in Alzheimer's disease Neurobiology of Aging. 13. DOI: 10.1016/0197-4580(92)90241-O |
0.427 |
|
| 1991 |
Small DH, Moir RD, Fuller SJ, Michaelson S, Bush AI, Li QX, Milward E, Hilbich C, Weidemann A, Beyreuther K. A protease activity associated with acetylcholinesterase releases the membrane-bound form of the amyloid protein precursor of Alzheimer's disease. Biochemistry. 30: 10795-9. PMID 1718425 DOI: 10.1021/Bi00108A027 |
0.506 |
|
| 1990 |
Masters CL, Bush A, Evin G, Fuller S, Li Q, Mackenzie I, Milward E, Moir R, Small D, Beyreuther K. The βA4 amyloid protein and its precursors as biological markers for Alzheimer's disease Neurobiology of Aging. 11: 330-331. DOI: 10.1016/0197-4580(90)90874-Y |
0.458 |
|
| 1988 |
Small DH, Chubb IW. Identification of a trypsin-like site associated with acetylcholinesterase by affinity labelling with [3H]diisopropyl fluorophosphate. Journal of Neurochemistry. 51: 69-74. PMID 3379413 DOI: 10.1111/J.1471-4159.1988.Tb04836.X |
0.309 |
|
| 1988 |
Kecorius E, Small DH, Livett BG. Characterization of a dipeptidyl aminopeptidase from bovine adrenal medulla. Journal of Neurochemistry. 50: 38-44. PMID 3335850 DOI: 10.1111/J.1471-4159.1988.Tb13226.X |
0.304 |
|
| 1988 |
Small DH, Simpson RJ. Acetylcholinesterase undergoes autolysis to generate trypsin-like activity. Neuroscience Letters. 89: 223-8. PMID 3292968 DOI: 10.1016/0304-3940(88)90385-0 |
0.311 |
|
| 1988 |
Small DH. Serum acetylcholinesterase possesses trypsin-like and carboxypeptidase B-like activity. Neuroscience Letters. 95: 307-12. PMID 3226617 DOI: 10.1016/0304-3940(88)90676-3 |
0.303 |
|
| 1987 |
Small DH, Ismael Z, Chubb IW. Acetylcholinesterase exhibits trypsin-like and metalloexopeptidase-like activity in cleaving a model peptide. Neuroscience. 21: 991-5. PMID 3306451 DOI: 10.1016/0306-4522(87)90053-4 |
0.323 |
|
| 1986 |
Small DH, Ismael Z, Chubb IW. Acetylcholinesterase hydrolyses chromogranin A to yield low molecular weight peptides. Neuroscience. 19: 289-95. PMID 3537842 DOI: 10.1016/0306-4522(86)90022-9 |
0.317 |
|
| 1986 |
Ismael Z, Millar TJ, Small DH, Chubb IW. Acetylcholinesterase generates enkephalin-like immunoreactivity when it degrades the soluble proteins (chromogranins) from adrenal chromaffin granules. Brain Research. 376: 230-8. PMID 3524746 DOI: 10.1016/0006-8993(86)90184-8 |
0.327 |
|
| 1985 |
Small DH, Wurtman RJ. Association of serotonin, dopamine, or noradrenaline with an actin-like component in pheochromocytoma (PC12) cells. Journal of Neurochemistry. 45: 825-31. PMID 4031865 DOI: 10.1111/j.1471-4159.1985.tb04068.x |
0.44 |
|
| 1985 |
Small DH, Wurtman RJ. Binding of [3H]serotonin to skeletal muscle actin. Journal of Neurochemistry. 45: 819-24. PMID 4031864 DOI: 10.1111/j.1471-4159.1985.tb04067.x |
0.438 |
|
| 1984 |
Small DH, Wurtman RJ. Serotonin binds specifically and saturably to an actin-like protein isolated from rat brain synaptosomes. Proceedings of the National Academy of Sciences of the United States of America. 81: 959-63. PMID 6583691 DOI: 10.1073/PNAS.81.3.959 |
0.471 |
|
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