Stephen Siu Chung Chim, Ph.D. - Publications

Obstetrics and Gynaecology The Chinese University of Hong Kong, Hong Kong, Hong Kong 
molecular prenatal diagnosis

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Year Citation  Score
2012 Poon TC, Pang RT, Chan KC, Lee NL, Chiu RW, Tong YK, Chim SS, Ngai SM, Sung JJ, Lo YM. Proteomic analysis reveals platelet factor 4 and beta-thromboglobulin as prognostic markers in severe acute respiratory syndrome. Electrophoresis. 33: 1894-900. PMID 22740477 DOI: 10.1002/elps.201200002  0.6
2011 Wong RR, Chan LK, Tsang TP, Lee CW, Cheung TH, Yim SF, Siu NS, Lee SN, Yu MY, Chim SS, Wong YF, Chung TK. CHD5 Downregulation Associated with Poor Prognosis in Epithelial Ovarian Cancer. Gynecologic and Obstetric Investigation. 72: 203-7. PMID 21860208 DOI: 10.1159/000323883  0.6
2011 Leung LC, Sung RY, So HK, Wong SN, Lee KW, Lee KP, Yam MC, Li SP, Yuen SF, Chim S, Chan KK, Luk D. Prevalence and risk factors for hypertension in Hong Kong Chinese adolescents: waist circumference predicts hypertension, exercise decreases risk. Archives of Disease in Childhood. 96: 804-9. PMID 21586437 DOI: 10.1136/adc.2010.202770  0.36
2010 Tsui DW, Lam YM, Lee WS, Leung TY, Lau TK, Lau ET, Tang MH, Akolekar R, Nicolaides KH, Chiu RW, Lo YM, Chim SS. Systematic identification of placental epigenetic signatures for the noninvasive prenatal detection of Edwards syndrome. Plos One. 5: e15069. PMID 21152411 DOI: 10.1371/journal.pone.0015069  0.6
2010 Kou CY, Lau SL, Au KW, Leung PY, Chim SS, Fung KP, Waye MM, Tsui SK. Epigenetic regulation of neonatal cardiomyocytes differentiation. Biochemical and Biophysical Research Communications. 400: 278-83. PMID 20735989 DOI: 10.1016/j.bbrc.2010.08.064  0.64
2009 Poon TC, Pang RT, Chan KC, Lee NL, Chiu RW, Tong YK, Chim SS, Ngai SM, Sung JJ, Lo YM. Proteomic profiling in SARS: diagnostic and prognostic applications. Hong Kong Medical Journal = Xianggang Yi Xue Za Zhi / Hong Kong Academy of Medicine. 15: 15-8. PMID 20393206  0.6
2009 Seto SW, Lam HY, Lau WS, Au AL, Lam TY, Chim SS, Ngai SM, Chan SW, Leung TY, Yeung JH, Kong SK, Leung GP, Lee SM, Kwan YW. Role of monoamine oxidases in the exaggerated 5-hydroxytryptamine-induced tension development of human isolated preeclamptic umbilical artery. European Journal of Pharmacology. 605: 129-37. PMID 19248248 DOI: 10.1016/j.ejphar.2008.12.054  0.6
2009 Hung EC, Shing TK, Chim SS, Yeung PC, Chan RW, Chik KW, Lee V, Tsui NB, Li CK, Wong CS, Chiu RW, Lo YM. Presence of donor-derived DNA and cells in the urine of sex-mismatched hematopoietic stem cell transplant recipients: implication for the transrenal hypothesis. Clinical Chemistry. 55: 715-22. PMID 18974360 DOI: 10.1373/clinchem.2008.113530  0.4
2008 Chim SS, Shing TK, Hung EC, Leung TY, Lau TK, Chiu RW, Lo YM. Detection and characterization of placental microRNAs in maternal plasma. Clinical Chemistry. 54: 482-90. PMID 18218722 DOI: 10.1373/clinchem.2007.097972  0.4
2008 Chim SS, Jin S, Lee TY, Lun FM, Lee WS, Chan LY, Jin Y, Yang N, Tong YK, Leung TY, Lau TK, Ding C, Chiu RW, Lo YM. Systematic search for placental DNA-methylation markers on chromosome 21: toward a maternal plasma-based epigenetic test for fetal trisomy 21. Clinical Chemistry. 54: 500-11. PMID 18202156 DOI: 10.1373/clinchem.2007.098731  0.6
2007 Tsui DW, Chan KC, Chim SS, Chan LW, Leung TY, Lau TK, Lo YM, Chiu RW. Quantitative aberrations of hypermethylated RASSF1A gene sequences in maternal plasma in pre-eclampsia. Prenatal Diagnosis. 27: 1212-8. PMID 17994635 DOI: 10.1002/pd.1897  0.4
2007 Seto SW, Au AL, Lam TY, Chim SS, Lee SM, Wan S, Tjiu DC, Shigemura N, Yim AP, Chan SW, Tsui SK, Leung GP, Kwan YW. Modulation by simvastatin of iberiotoxin-sensitive, Ca2+-activated K+ channels of porcine coronary artery smooth muscle cells. British Journal of Pharmacology. 151: 987-97. PMID 17558433 DOI: 10.1038/sj.bjp.0707327  0.6
2007 Chiu RW, Chim SS, Wong IH, Wong CS, Lee WS, To KF, Tong JH, Yuen RK, Shum AS, Chan JK, Chan LY, Yuen JW, Tong YK, Weier JF, Ferlatte C, et al. Hypermethylation of RASSF1A in human and rhesus placentas. The American Journal of Pathology. 170: 941-50. PMID 17322379 DOI: 10.2353/ajpath.2007.060641  0.6
2007 Van Dijk M, Van Bezu J, Chim SS, Lo YMD, Blankenstein MA, Oudejans CBM. Reply to STOX1 is not imprinted and is not likely to be involved in preeclampsia [2] Nature Genetics. 39: 280-281. DOI: 10.1038/ng0307-280  0.6
2006 Chan KC, Ding C, Gerovassili A, Yeung SW, Chiu RW, Leung TN, Lau TK, Chim SS, Chung GT, Nicolaides KH, Lo YM. Hypermethylated RASSF1A in maternal plasma: A universal fetal DNA marker that improves the reliability of noninvasive prenatal diagnosis. Clinical Chemistry. 52: 2211-8. PMID 17068167 DOI: 10.1373/clinchem.2006.074997  0.6
2006 Tong YK, Ding C, Chiu RW, Gerovassili A, Chim SS, Leung TY, Leung TN, Lau TK, Nicolaides KH, Lo YM. Noninvasive prenatal detection of fetal trisomy 18 by epigenetic allelic ratio analysis in maternal plasma: Theoretical and empirical considerations. Clinical Chemistry. 52: 2194-202. PMID 17040955 DOI: 10.1373/clinchem.2006.076851  0.6
2006 Chim SS, Chiu RW, Lo YM. Genomic sequencing of the severe acute respiratory syndrome-coronavirus. Methods in Molecular Biology (Clifton, N.J.). 336: 177-94. PMID 16916263 DOI: 10.1385/1-59745-074-X:177  0.4
2006 Pang RT, Poon TC, Chan KC, Lee NL, Chiu RW, Tong YK, Chim SS, Sung JJ, Lo YM. Serum amyloid A is not useful in the diagnosis of severe acute respiratory syndrome. Clinical Chemistry. 52: 1202-4. PMID 16723685 DOI: 10.1373/clinchem.2006.068395  0.4
2006 Au KW, Kou CY, Woo AY, Chim SS, Fung KP, Cheng CH, Waye MM, Tsui SK. Calcyclin binding protein promotes DNA synthesis and differentiation in rat neonatal cardiomyocytes. Journal of Cellular Biochemistry. 98: 555-66. PMID 16440310 DOI: 10.1002/jcb.20710  0.64
2006 Pang RT, Poon TC, Chan KC, Lee NL, Chiu RW, Tong YK, Wong RM, Chim SS, Ngai SM, Sung JJ, Lo YM. Serum proteomic fingerprints of adult patients with severe acute respiratory syndrome. Clinical Chemistry. 52: 421-9. PMID 16423906 DOI: 10.1373/clinchem.2005.061689  0.6
2005 Chung GT, Chiu RW, Cheung JL, Jin Y, Chim SS, Chan PK, Lo YM. A simple and rapid approach for screening of SARS-coronavirus genotypes: an evaluation study. Bmc Infectious Diseases. 5: 87. PMID 16229749 DOI: 10.1186/1471-2334-5-87  0.4
2005 Chim SS, Tong YK, Chiu RW, Lau TK, Leung TN, Chan LY, Oudejans CB, Ding C, Lo YM. Detection of the placental epigenetic signature of the maspin gene in maternal plasma. Proceedings of the National Academy of Sciences of the United States of America. 102: 14753-8. PMID 16203989 DOI: 10.1073/pnas.0503335102  0.6
2005 Chan KC, Tang NL, Hui DS, Chung GT, Wu AK, Chim SS, Chiu RW, Lee N, Choi KW, Sung YM, Chan PK, Tong YK, Lai ST, Yu WC, Tsang O, et al. Absence of association between angiotensin converting enzyme polymorphism and development of adult respiratory distress syndrome in patients with severe acute respiratory syndrome: a case control study. Bmc Infectious Diseases. 5: 26. PMID 15819995 DOI: 10.1186/1471-2334-5-26  0.4
2005 Chiu RW, Chim SS, Tong YK, Fung KS, Chan PK, Zhao GP, Lo YM. Tracing SARS-coronavirus variant with large genomic deletion. Emerging Infectious Diseases. 11: 168-70. PMID 15714661 DOI: 10.3201/eid1101.040544  0.4
2004 Chim SS, Lo YM. Molecular epidemiology of the coronavirus associated with severe acute respiratory syndrome: a review of data from the Chinese University of Hong Kong. The Clinical Biochemist. Reviews / Australian Association of Clinical Biochemists. 25: 143-7. PMID 18458710  0.4
2004 Chiu RW, Tang NL, Hui DS, Chung GT, Chim SS, Chan KC, Sung YM, Chan LY, Tong YK, Lee WS, Chan PK, Lo YM. ACE2 gene polymorphisms do not affect outcome of severe acute respiratory syndrome. Clinical Chemistry. 50: 1683-6. PMID 15331509 DOI: 10.1373/clinchem.2004.035436  0.4
2004 Tsui NB, Chim SS, Chiu RW, Lau TK, Ng EK, Leung TN, Tong YK, Chan KC, Lo YM. Systematic micro-array based identification of placental mRNA in maternal plasma: towards non-invasive prenatal gene expression profiling. Journal of Medical Genetics. 41: 461-7. PMID 15173234  0.64
2004 To KF, Tong JH, Chan PK, Au FW, Chim SS, Chan KC, Cheung JL, Liu EY, Tse GM, Lo AW, Lo YM, Ng HK. Tissue and cellular tropism of the coronavirus associated with severe acute respiratory syndrome: an in-situ hybridization study of fatal cases. The Journal of Pathology. 202: 157-63. PMID 14743497 DOI: 10.1002/path.1510  0.4
2004 Chim SS, Tong YK, Hung EC, Chiu RW, Lo YM. Genomic sequencing of a SARS coronavirus isolate that predated the Metropole Hotel case cluster in Hong Kong. Clinical Chemistry. 50: 231-3. PMID 14709660 DOI: 10.1373/clinchem.2003.025536  0.4
2003 Chim SS, Tsui SK, Chan KC, Au TC, Hung EC, Tong YK, Chiu RW, Ng EK, Chan PK, Chu CM, Sung JJ, Tam JS, Fung KP, Waye MM, Lee CY, et al. Genomic characterisation of the severe acute respiratory syndrome coronavirus of Amoy Gardens outbreak in Hong Kong. Lancet (London, England). 362: 1807-8. PMID 14654320  0.64
2003 Hung EC, Chim SS, Chan PK, Tong YK, Ng EK, Chiu RW, Leung CB, Sung JJ, Tam JS, Lo YM. Detection of SARS coronavirus RNA in the cerebrospinal fluid of a patient with severe acute respiratory syndrome. Clinical Chemistry. 49: 2108-9. PMID 14633896 DOI: 10.1373/clinchem.2003.025437  0.64
2003 Ng EK, Hui DS, Chan KC, Hung EC, Chiu RW, Lee N, Wu A, Chim SS, Tong YK, Sung JJ, Tam JS, Lo YM. Quantitative analysis and prognostic implication of SARS coronavirus RNA in the plasma and serum of patients with severe acute respiratory syndrome. Clinical Chemistry. 49: 1976-80. PMID 14633867 DOI: 10.1373/clinchem.2003.024125  0.64
2003 Chiu RW, Chim SS, Lo YM. Molecular epidemiology of SARS--from Amoy Gardens to Taiwan. The New England Journal of Medicine. 349: 1875-6. PMID 14602893 DOI: 10.1056/NEJM200311063491923  0.4
2003 Tsui SK, Chim SS, Lo YM. Coronavirus genomic-sequence variations and the epidemiology of the severe acute respiratory syndrome. The New England Journal of Medicine. 349: 187-8. PMID 12853594 DOI: 10.1056/NEJM200307103490216  0.64
2001 Chan AH, Lee SM, Chim SS, Kok LD, Waye MM, Lee CY, Fung KP, Tsui SK. Molecular cloning and characterization of a RING-H2 finger protein, ANAPC11, the human homolog of yeast Apc11p. Journal of Cellular Biochemistry. 83: 249-58. PMID 11573242 DOI: 10.1002/jcb.1217  0.64
2000 Chim SS, Cheung SS, Tsui SK. Differential gene expression of rat neonatal heart analyzed by suppression subtractive hybridization and expressed sequence tag sequencing. Journal of Cellular Biochemistry. 80: 24-36. PMID 11029751 DOI: 10.1002/1097-4644(20010101)80:1<24::AID-JCB30>3.0.CO;2-P  0.6
2000 Chim SS, Fung K, Waye MM, Lee C, Tsui SK. Expression of replication factor C 40-kDa subunit is down-regulated during neonatal development in rat ventricular myocardium. Journal of Cellular Biochemistry. 78: 533-40. PMID 10861850 DOI: 10.1002/1097-4644(20000915)78:4<533::AID-JCB2>3.0.CO;2-7  0.64
1999 Lee SM, Li HY, Ng EK, Or SM, Chan KK, Kotaka M, Chim SS, Tsui SK, Waye MM, Fung KP, Lee CY. Characterization of a brain-specific nuclear LIM domain protein (FHL1B) which is an alternatively spliced variant of FHL1. Gene. 237: 253-63. PMID 10524257  0.64
1998 Lee SM, Tsui SK, Chan KK, Kotaka M, Li HY, Chim SS, Waye MM, Fung KP, Lee CY. Chromosomal mapping of a skeletal muscle specific LIM-only protein FHL3 to the distal end of the short arm of human chromosome 1. Somatic Cell and Molecular Genetics. 24: 197-202. PMID 10226657  0.64
1998 Garcia-Barcelo M, Tsui SK, Chim SS, Fung KP, Lee CY, Waye MM. Mapping of the human cysteine-rich intestinal protein gene CRIP1 to the human chromosomal segment 7q11.23. Genomics. 47: 419-22. PMID 9480758 DOI: 10.1006/geno.1997.5134  0.64
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