John Hiscott, Ph.D. - Publications

Affiliations: 
Medicine, Microbiology& Immunology and Oncology McGill University, Montreal, QC, Canada 
Area:
regulation of gene expression in cancer cells, development of immune response modifiers and analysis of the immune response to virus infection

233 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Acchioni C, Remoli AL, Marsili G, Acchioni M, Nardolillo I, Orsatti R, Farcomeni S, Palermo E, Perrotti E, Barreca ML, Sabatini S, Sandini S, Parolin C, Lin R, Borsetti A, ... Hiscott J, et al. Alternate NF-κB independent signaling re-activation of latent HIV-1 provirus. Journal of Virology. PMID 31243131 DOI: 10.1128/Jvi.00495-19  0.72
2017 Olagnier D, Lababidi RR, Hadj SB, Sze A, Liu Y, Naidu SD, Ferrari M, Jiang Y, Chiang C, Beljanski V, Goulet ML, Knatko EV, Dinkova-Kostova AT, Hiscott J, Lin R. Activation of Nrf2 Signaling Augments Vesicular Stomatitis Virus Oncolysis via Autophagy-Driven Suppression of Antiviral Immunity. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 28527723 DOI: 10.1016/J.Ymthe.2017.04.022  0.72
2016 Olagnier D, Amatore D, Castiello L, Ferrari M, Palermo E, Diamond MS, Palamara AT, Hiscott J. Dengue Virus Immunopathogenesis: Lessons Applicable to the Emergence of Zika Virus. Journal of Molecular Biology. PMID 27130436 DOI: 10.1016/J.Jmb.2016.04.024  0.72
2015 Goubau D, van der Veen AG, Chakravarty P, Lin R, Rogers N, Rehwinkel J, Deddouche S, Rosewell I, Hiscott J, Reis E Sousa-C C. Mouse superkiller-2-like helicase DDX60 is dispensable for type I IFN induction and immunity to multiple viruses. European Journal of Immunology. PMID 26457795 DOI: 10.1002/Eji.201545794  0.72
2015 Pinto AK, Brien JD, Lam CY, Johnson S, Chiang C, Hiscott J, Sarathy VV, Barrett AD, Shresta S, Diamond MS. Defining New Therapeutics Using a More Immunocompetent Mouse Model of Antibody-Enhanced Dengue Virus Infection. Mbio. 6. PMID 26374123 DOI: 10.1128/Mbio.01316-15  0.72
2015 Beljanski V, Chiang C, Kirchenbaum GA, Olagnier D, Bloom CE, Wong T, Haddad EK, Trautmann L, Ross TM, Hiscott J. Enhanced Influenza Virus-Like Particle Vaccination with a Structurally Optimized RIG-I Agonist as Adjuvant. Journal of Virology. 89: 10612-24. PMID 26269188 DOI: 10.1128/Jvi.01526-15  0.72
2015 Li S, Pinard M, Wang Y, Yang L, Lin R, Hiscott J, Su B, Brodt P. Crosstalk between the TNF and IGF pathways enhances NF-κB activation and signaling in cancer cells. Growth Hormone & Igf Research : Official Journal of the Growth Hormone Research Society and the International Igf Research Society. PMID 26239406 DOI: 10.1016/J.Ghir.2015.07.008  0.72
2015 Beljanski V, Chiang C, Hiscott J. The intersection between viral oncolysis, drug resistance, and autophagy. Biological Chemistry. 396: 1269-80. PMID 26068902 DOI: 10.1515/Hsz-2015-0147  0.72
2015 Chiang C, Beljanski V, Yin K, Olagnier D, Ben Yebdri F, Steel C, Goulet ML, DeFilippis VR, Streblow DN, Haddad EK, Trautmann L, Ross T, Lin R, Hiscott J. Sequence-Specific Modifications Enhance the Broad-Spectrum Antiviral Response Activated by RIG-I Agonists. Journal of Virology. 89: 8011-25. PMID 26018150 DOI: 10.1128/Jvi.00845-15  0.72
2015 Zhou Q, Lavorgna A, Bowman M, Hiscott J, Harhaj EW. Aryl Hydrocarbon Receptor Interacting Protein Targets IRF7 to Suppress Antiviral Signaling and the Induction of Type I Interferon. The Journal of Biological Chemistry. 290: 14729-39. PMID 25911105 DOI: 10.1074/Jbc.M114.633065  0.72
2015 Metcalf TU, Cubas RA, Ghneim K, Cartwright MJ, Grevenynghe JV, Richner JM, Olagnier DP, Wilkinson PA, Cameron MJ, Park BS, Hiscott JB, Diamond MS, Wertheimer AM, Nikolich-Zugich J, Haddad EK. Global analyses revealed age-related alterations in innate immune responses after stimulation of pathogen recognition receptors. Aging Cell. 14: 421-32. PMID 25728020 DOI: 10.1111/Acel.12320  0.72
2015 Jakobsen MR, Olagnier D, Hiscott J. Innate immune sensing of HIV-1 infection. Current Opinion in Hiv and Aids. 10: 96-102. PMID 25485569 DOI: 10.1097/Coh.0000000000000129  0.72
2014 Olagnier D, Sze A, Bel Hadj S, Chiang C, Steel C, Han X, Routy JP, Lin R, Hiscott J, van Grevenynghe J. HTLV-1 Tax-mediated inhibition of FOXO3a activity is critical for the persistence of terminally differentiated CD4+ T cells. Plos Pathogens. 10: e1004575. PMID 25521510 DOI: 10.1371/Journal.Ppat.1004575  0.72
2014 Olagnier D, Peri S, Steel C, van Montfoort N, Chiang C, Beljanski V, Slifker M, He Z, Nichols CN, Lin R, Balachandran S, Hiscott J. Cellular oxidative stress response controls the antiviral and apoptotic programs in dengue virus-infected dendritic cells. Plos Pathogens. 10: e1004566. PMID 25521078 DOI: 10.1371/Journal.Ppat.1004566  0.72
2014 Hiscott J. Introduction to innate sensing and response to pathogens (part 2). Cytokine & Growth Factor Reviews. 25: 629-30. PMID 25458908 DOI: 10.1016/J.Cytogfr.2014.11.001  0.72
2014 Hiscott J. Introduction to innate sensing and response to pathogens. Cytokine & Growth Factor Reviews. 25: 489-90. PMID 25443974 DOI: 10.1016/J.Cytogfr.2014.09.004  0.72
2014 Arguello M, Paz S, Ferran C, Moll HP, Hiscott J. Anti-viral tetris: modulation of the innate anti-viral immune response by A20. Advances in Experimental Medicine and Biology. 809: 49-64. PMID 25302365 DOI: 10.1007/978-1-4939-0398-6_4  0.72
2014 Kreher S, Bouhlel MA, Cauchy P, Lamprecht B, Li S, Grau M, Hummel F, Köchert K, Anagnostopoulos I, Jöhrens K, Hummel M, Hiscott J, Wenzel SS, Lenz P, Schneider M, et al. Mapping of transcription factor motifs in active chromatin identifies IRF5 as key regulator in classical Hodgkin lymphoma. Proceedings of the National Academy of Sciences of the United States of America. 111: E4513-22. PMID 25288773 DOI: 10.1073/Pnas.1406985111  0.72
2014 van Montfoort N, Olagnier D, Hiscott J. Unmasking immune sensing of retroviruses: interplay between innate sensors and host effectors. Cytokine & Growth Factor Reviews. 25: 657-68. PMID 25240798 DOI: 10.1016/J.Cytogfr.2014.08.006  0.72
2014 Feng Q, Langereis MA, Olagnier D, Chiang C, van de Winkel R, van Essen P, Zoll J, Hiscott J, van Kuppeveld FJ. Coxsackievirus cloverleaf RNA containing a 5' triphosphate triggers an antiviral response via RIG-I activation. Plos One. 9: e95927. PMID 24759703 DOI: 10.1371/Journal.Pone.0095927  0.72
2014 Olagnier D, Hiscott J. Type I and type III interferon-induced immune response: it's a matter of kinetics and magnitude. Hepatology (Baltimore, Md.). 59: 1225-8. PMID 24677190 DOI: 10.1002/Hep.26959  0.72
2014 Barbeau B, Hiscott J, Bazarbachi A, Carvalho E, Jones K, Martin F, Matsuoka M, Murphy EL, Ratner L, Switzer WM, Watanabe T. Conference highlights of the 16th International Conference on Human Retrovirology: HTLV and related retroviruses, 26-30 June 2013, Montreal, Canada. Retrovirology. 11: 19. PMID 24558960 DOI: 10.1186/1742-4690-11-19  0.72
2014 Olagnier D, Scholte FE, Chiang C, Albulescu IC, Nichols C, He Z, Lin R, Snijder EJ, van Hemert MJ, Hiscott J. Inhibition of dengue and chikungunya virus infections by RIG-I-mediated type I interferon-independent stimulation of the innate antiviral response. Journal of Virology. 88: 4180-94. PMID 24478443 DOI: 10.1128/Jvi.03114-13  0.72
2014 Sgarbanti M, Marsili G, Remoli AL, Stellacci E, Mai A, Rotili D, Perrotti E, Acchioni C, Orsatti R, Iraci N, Ferrari M, Borsetti A, Hiscott J, Battistini A. IκB kinase ε targets interferon regulatory factor 1 in activated T lymphocytes. Molecular and Cellular Biology. 34: 1054-65. PMID 24396068 DOI: 10.1128/Mcb.01161-13  0.72
2014 Shulak L, Beljanski V, Chiang C, Dutta SM, Van Grevenynghe J, Belgnaoui SM, Nguyên TL, Di Lenardo T, Semmes OJ, Lin R, Hiscott J. Histone deacetylase inhibitors potentiate vesicular stomatitis virus oncolysis in prostate cancer cells by modulating NF-κB-dependent autophagy. Journal of Virology. 88: 2927-40. PMID 24371063 DOI: 10.1128/Jvi.03406-13  0.72
2013 Goulet ML, Olagnier D, Xu Z, Paz S, Belgnaoui SM, Lafferty EI, Janelle V, Arguello M, Paquet M, He Z, Ghneim K, Richards S, Smith A, Wilkinson P, Cameron M, ... ... Hiscott J, et al. Correction: Systems Analysis of a RIG-I Agonist Inducing Broad Spectrum Inhibition of Virus Infectivity. Plos Pathogens. 9. PMID 29294479 DOI: 10.1371/Annotation/8Fa70B21-32E7-4Ed3-B397-Ab776B5Bbf30  0.72
2013 Sze A, Olagnier D, Lin R, van Grevenynghe J, Hiscott J. SAMHD1 host restriction factor: a link with innate immune sensing of retrovirus infection. Journal of Molecular Biology. 425: 4981-94. PMID 24161438 DOI: 10.1016/J.Jmb.2013.10.022  0.72
2013 Sze A, Belgnaoui SM, Olagnier D, Lin R, Hiscott J, van Grevenynghe J. Host restriction factor SAMHD1 limits human T cell leukemia virus type 1 infection of monocytes via STING-mediated apoptosis. Cell Host & Microbe. 14: 422-34. PMID 24139400 DOI: 10.1016/J.Chom.2013.09.009  0.72
2013 Bosinger SE, Johnson ZP, Folkner KA, Patel N, Hashempour T, Jochems SP, Del Rio Estrada PM, Paiardini M, Lin R, Vanderford TH, Hiscott J, Silvestri G. Intact type I Interferon production and IRF7 function in sooty mangabeys. Plos Pathogens. 9: e1003597. PMID 24009514 DOI: 10.1371/Journal.Ppat.1003597  0.72
2013 Ben Yebdri F, Van Grevenynghe J, Tang VA, Goulet ML, Wu JH, Stojdl DF, Hiscott J, Lin R. Triptolide-mediated inhibition of interferon signaling enhances vesicular stomatitis virus-based oncolysis. Molecular Therapy : the Journal of the American Society of Gene Therapy. 21: 2043-53. PMID 23985699 DOI: 10.1038/Mt.2013.187  0.72
2013 Samuel S, Beljanski V, Van Grevenynghe J, Richards S, Ben Yebdri F, He Z, Nichols C, Belgnaoui SM, Steel C, Goulet ML, Shamy A, Brown D, Abesada G, Haddad EK, Hiscott J. BCL-2 inhibitors sensitize therapy-resistant chronic lymphocytic leukemia cells to VSV oncolysis. Molecular Therapy : the Journal of the American Society of Gene Therapy. 21: 1413-23. PMID 23689597 DOI: 10.1038/Mt.2013.91  0.72
2013 Goulet ML, Olagnier D, Xu Z, Paz S, Belgnaoui SM, Lafferty EI, Janelle V, Arguello M, Paquet M, Ghneim K, Richards S, Smith A, Wilkinson P, Cameron M, Kalinke U, ... ... Hiscott J, et al. Systems analysis of a RIG-I agonist inducing broad spectrum inhibition of virus infectivity. Plos Pathogens. 9: e1003298. PMID 23633948 DOI: 10.1371/Journal.Ppat.1003298  0.72
2013 Hariri F, Arguello M, Volpon L, Culjkovic-Kraljacic B, Nielsen TH, Hiscott J, Mann KK, Borden KL. The eukaryotic translation initiation factor eIF4E is a direct transcriptional target of NF-κB and is aberrantly regulated in acute myeloid leukemia. Leukemia. 27: 2047-55. PMID 23467026 DOI: 10.1038/Leu.2013.73  0.72
2013 Bobardt M, Hopkins S, Baugh J, Chatterji U, Hernandez F, Hiscott J, Sluder A, Lin K, Gallay PA. HCV NS5A and IRF9 compete for CypA binding. Journal of Hepatology. 58: 16-23. PMID 22902549 DOI: 10.1016/j.jhep.2012.08.007  0.72
2013 Yebdri FB, VanGrevenynghe J, Tang VA, Goulet M, Wu J, Stojdl DF, Hiscott J, Lin R. 289: Triptolide mediated-inhibition of interferon signaling enhances vesicular stomatitis virus based oncolysis Cytokine. 63: 312. DOI: 10.1016/J.Cyto.2013.06.292  0.72
2012 Beljanski V, Hiscott J. The use of oncolytic viruses to overcome lung cancer drug resistance. Current Opinion in Virology. 2: 629-35. PMID 22910124 DOI: 10.1016/J.Coviro.2012.07.006  0.72
2012 Belgnaoui SM, Paz S, Samuel S, Goulet ML, Sun Q, Kikkert M, Iwai K, Dikic I, Hiscott J, Lin R. Linear ubiquitination of NEMO negatively regulates the interferon antiviral response through disruption of the MAVS-TRAF3 complex. Cell Host & Microbe. 12: 211-22. PMID 22901541 DOI: 10.1016/J.Chom.2012.06.009  0.72
2012 Olagnier D, Hiscott J. Breaking the barrier: membrane fusion triggers innate antiviral immunity. Nature Immunology. 13: 713-5. PMID 22814341 DOI: 10.1038/Ni.2373  0.72
2012 Haddad EK, Hiscott J. Cytokine networks during HIV infection: shifting the balance. Cytokine & Growth Factor Reviews. 23: 139-41. PMID 22766355 DOI: 10.1016/J.Cytogfr.2012.05.012  0.72
2012 Lei Y, Wen H, Yu Y, Taxman DJ, Zhang L, Widman DG, Swanson KV, Wen KW, Damania B, Moore CB, Giguère PM, Siderovski DP, Hiscott J, Razani B, Semenkovich CF, et al. The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy. Immunity. 36: 933-46. PMID 22749352 DOI: 10.1016/J.Immuni.2012.03.025  0.72
2012 Génin P, Lin R, Hiscott J, Civas A. Recruitment of histone deacetylase 3 to the interferon-A gene promoters attenuates interferon expression. Plos One. 7: e38336. PMID 22685561 DOI: 10.1371/Journal.Pone.0038336  0.72
2012 Nakhaei P, Sun Q, Solis M, Mesplede T, Bonneil E, Paz S, Lin R, Hiscott J. IκB kinase ε-dependent phosphorylation and degradation of X-linked inhibitor of apoptosis sensitizes cells to virus-induced apoptosis. Journal of Virology. 86: 726-37. PMID 22072751 DOI: 10.1128/Jvi.05989-11  0.56
2011 Hiscott J, Ware C. Cytokines. Current Opinion in Immunology. 23: 561-3. PMID 21982509 DOI: 10.1016/j.coi.2011.09.001  0.72
2011 Olière S, Douville R, Sze A, Belgnaoui SM, Hiscott J. Modulation of innate immune responses during human T-cell leukemia virus (HTLV-1) pathogenesis. Cytokine & Growth Factor Reviews. 22: 197-210. PMID 21924945 DOI: 10.1016/J.Cytogfr.2011.08.002  0.72
2011 Leveille S, Goulet ML, Lichty BD, Hiscott J. Vesicular stomatitis virus oncolytic treatment interferes with tumor-associated dendritic cell functions and abrogates tumor antigen presentation. Journal of Virology. 85: 12160-9. PMID 21917977 DOI: 10.1128/Jvi.05703-11  0.72
2011 Belgnaoui SM, Paz S, Hiscott J. Orchestrating the interferon antiviral response through the mitochondrial antiviral signaling (MAVS) adapter. Current Opinion in Immunology. 23: 564-72. PMID 21865020 DOI: 10.1016/J.Coi.2011.08.001  0.72
2011 Piya S, Moon AR, Song PI, Hiscott J, Lin R, Seol DW, Kim TH. Suppression of IRF4 by IRF1, 3, and 7 in Noxa expression is a necessary event for IFN-γ-mediated tumor elimination. Molecular Cancer Research : McR. 9: 1356-65. PMID 21816905 DOI: 10.1158/1541-7786.Mcr-11-0185  0.72
2011 Leveille S, Samuel S, Goulet ML, Hiscott J. Enhancing VSV oncolytic activity with an improved cytosine deaminase suicide gene strategy. Cancer Gene Therapy. 18: 435-43. PMID 21394109 DOI: 10.1038/cgt.2011.14  0.72
2011 Paz S, Vilasco M, Werden SJ, Arguello M, Joseph-Pillai D, Zhao T, Nguyen TL, Sun Q, Meurs EF, Lin R, Hiscott J. A functional C-terminal TRAF3-binding site in MAVS participates in positive and negative regulation of the IFN antiviral response. Cell Research. 21: 895-910. PMID 21200404 DOI: 10.1038/Cr.2011.2  0.72
2011 Solis M, Nakhaei P, Jalalirad M, Lacoste J, Douville R, Arguello M, Zhao T, Laughrea M, Wainberg MA, Hiscott J. RIG-I-mediated antiviral signaling is inhibited in HIV-1 infection by a protease-mediated sequestration of RIG-I. Journal of Virology. 85: 1224-36. PMID 21084468 DOI: 10.1128/Jvi.01635-10  0.72
2011 Oldak M, Tolzmann L, Wnorowski A, Podgórska MJ, Silling S, Lin R, Hiscott J, Müller CS, Vogt T, Smola H, Smola S. Differential regulation of human papillomavirus type 8 by interferon regulatory factors 3 and 7. Journal of Virology. 85: 178-88. PMID 20980500 DOI: 10.1128/Jvi.00998-10  0.72
2010 Diallo JS, Boeuf FL, Lai F, Cox J, Vaha-Koskela M, Abdelbary H, MacTavish H, Waite K, Falls T, Wang J, Brown R, Blanchard JE, Brown ED, Kirn DH, Hiscott J, et al. A High-throughput Pharmacoviral Approach Identifies Novel Oncolytic Virus Sensitizers. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 1123-1129. PMID 28178494 DOI: 10.1038/mt.2010.67  0.36
2010 Paz S, Hiscott J. CuRTAiling interferon regulatory factor signaling with the E3 ligase RAUL. Immunity. 33: 833-5. PMID 21168773 DOI: 10.1016/J.Immuni.2010.12.006  0.72
2010 Olière S, Hernandez E, Lézin A, Arguello M, Douville R, Nguyen TL, Olindo S, Panelatti G, Kazanji M, Wilkinson P, Sékaly RP, Césaire R, Hiscott J. HTLV-1 evades type I interferon antiviral signaling by inducing the suppressor of cytokine signaling 1 (SOCS1). Plos Pathogens. 6: e1001177. PMID 21079688 DOI: 10.1371/Journal.Ppat.1001177  0.72
2010 Samuel S, Tumilasci VF, Oliere S, Nguyên TL, Shamy A, Bell J, Hiscott J. VSV oncolysis in combination with the BCL-2 inhibitor obatoclax overcomes apoptosis resistance in chronic lymphocytic leukemia. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 2094-103. PMID 20842105 DOI: 10.1038/Mt.2010.188  0.72
2010 Lin R, Paz S, Hiscott J. Tom70 imports antiviral immunity to the mitochondria. Cell Research. 20: 971-3. PMID 20680033 DOI: 10.1038/Cr.2010.113  0.72
2010 Douville RN, Hiscott J. The interface between the innate interferon response and expression of host retroviral restriction factors. Cytokine. 52: 108-15. PMID 20627758 DOI: 10.1016/J.Cyto.2010.04.010  0.72
2010 Luig C, Köther K, Dudek SE, Gaestel M, Hiscott J, Wixler V, Ludwig S. MAP kinase-activated protein kinases 2 and 3 are required for influenza A virus propagation and act via inhibition of PKR. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 4068-77. PMID 20484669 DOI: 10.1096/fj.10-158766  0.72
2010 Nguyen TL, Wilson MG, Hiscott J. Oncolytic viruses and histone deacetylase inhibitors--a multi-pronged strategy to target tumor cells. Cytokine & Growth Factor Reviews. 21: 153-9. PMID 20395162 DOI: 10.1016/J.Cytogfr.2010.03.002  0.72
2010 Diallo JS, Le Boeuf F, Lai F, Cox J, Vaha-Koskela M, Abdelbary H, MacTavish H, Waite K, Falls T, Wang J, Brown R, Blanchard JE, Brown ED, Kirn DH, Hiscott J, et al. A high-throughput pharmacoviral approach identifies novel oncolytic virus sensitizers. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 1123-9. PMID 20389287 DOI: 10.1038/Mt.2010.67  0.72
2010 Nakhaei P, Hiscott J, Lin R. STING-ing the antiviral pathway. Journal of Molecular Cell Biology. 2: 110-2. PMID 20022884 DOI: 10.1093/Jmcb/Mjp048  0.72
2010 Li S, Yang L, Lin R, Hiscott J, Brodt P. Abstract 554: Crosstalk between TNF-α and IGF signalling increases IL-6 production and protects tumor cells from TNF-α-induced apoptosis in the liver Cancer Research. 70: 554-554. DOI: 10.1158/1538-7445.Am10-554  0.72
2009 Nakhaei P, Mesplede T, Solis M, Sun Q, Zhao T, Yang L, Chuang TH, Ware CF, Lin R, Hiscott J. The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation. Plos Pathogens. 5: e1000650. PMID 19893624 DOI: 10.1016/J.Cyto.2009.07.540  0.72
2009 Vitour D, Dabo S, Ahmadi Pour M, Vilasco M, Vidalain PO, Jacob Y, Mezel-Lemoine M, Paz S, Arguello M, Lin R, Tangy F, Hiscott J, Meurs EF. Polo-like kinase 1 (PLK1) regulates interferon (IFN) induction by MAVS. The Journal of Biological Chemistry. 284: 21797-809. PMID 19546225 DOI: 10.1074/Jbc.M109.018275  0.72
2009 Nakhaei P, Genin P, Civas A, Hiscott J. RIG-I-like receptors: sensing and responding to RNA virus infection. Seminars in Immunology. 21: 215-22. PMID 19539500 DOI: 10.1016/J.Smim.2009.05.001  0.72
2009 Yang L, Zhao T, Shi X, Nakhaei P, Wang Y, Sun Q, Hiscott J, Lin R. Functional analysis of a dominant negative mutation of interferon regulatory factor 5. Plos One. 4: e5500. PMID 19430534 DOI: 10.1371/Journal.Pone.0005500  0.72
2009 Nguyen TL, Tumilasci VF, Singhroy D, Arguello M, Hiscott J. The emergence of combinatorial strategies in the development of RNA oncolytic virus therapies. Cellular Microbiology. 11: 889-97. PMID 19388908 DOI: 10.1111/J.1462-5822.2009.01317.X  0.72
2009 Paz S, Vilasco M, Arguello M, Sun Q, Lacoste J, Nguyen TL, Zhao T, Shestakova EA, Zaari S, Bibeau-Poirier A, Servant MJ, Lin R, Meurs EF, Hiscott J. Ubiquitin-regulated recruitment of IkappaB kinase epsilon to the MAVS interferon signaling adapter. Molecular and Cellular Biology. 29: 3401-12. PMID 19380491 DOI: 10.1128/Mcb.00880-08  0.72
2009 Génin P, Lin R, Hiscott J, Civas A. Differential regulation of human interferon A gene expression by interferon regulatory factors 3 and 7. Molecular and Cellular Biology. 29: 3435-50. PMID 19349300 DOI: 10.1128/Mcb.01805-08  0.72
2009 Goubau D, Romieu-Mourez R, Solis M, Hernandez E, Mesplède T, Lin R, Leaman D, Hiscott J. Transcriptional re-programming of primary macrophages reveals distinct apoptotic and anti-tumoral functions of IRF-3 and IRF-7. European Journal of Immunology. 39: 527-40. PMID 19152337 DOI: 10.1002/Eji.200838832  0.72
2009 Hiscott J. Editorial Cytokine and Growth Factor Reviews. 20: 95. DOI: 10.1016/j.cytogfr.2009.02.001  0.72
2008 Nguyên TL, Abdelbary H, Arguello M, Breitbach C, Leveille S, Diallo JS, Yasmeen A, Bismar TA, Kirn D, Falls T, Snoulten VE, Vanderhyden BC, Werier J, Atkins H, Vähä-Koskela MJ, ... ... Hiscott J, et al. Chemical targeting of the innate antiviral response by histone deacetylase inhibitors renders refractory cancers sensitive to viral oncolysis. Proceedings of the National Academy of Sciences of the United States of America. 105: 14981-6. PMID 18815361 DOI: 10.1073/Pnas.0803988105  0.72
2008 Tumilasci VF, Olière S, Nguyên TL, Shamy A, Bell J, Hiscott J. Targeting the apoptotic pathway with BCL-2 inhibitors sensitizes primary chronic lymphocytic leukemia cells to vesicular stomatitis virus-induced oncolysis. Journal of Virology. 82: 8487-99. PMID 18579592 DOI: 10.1128/Jvi.00851-08  0.72
2008 Oliere S, Arguello M, Mesplede T, Tumilasci V, Nakhaei P, Stojdl D, Sonenberg N, Bell J, Hiscott J. Vesicular stomatitis virus oncolysis of T lymphocytes requires cell cycle entry and translation initiation. Journal of Virology. 82: 5735-49. PMID 18417567 DOI: 10.1128/Jvi.02601-07  0.72
2008 Escors D, Lopes L, Lin R, Hiscott J, Akira S, Davis RJ, Collins MK. Targeting dendritic cell signaling to regulate the response to immunization. Blood. 111: 3050-61. PMID 18180378 DOI: 10.1182/Blood-2007-11-122408  0.72
2007 Arguello MD, Hiscott J. Ub surprised: viral ovarian tumor domain proteases remove ubiquitin and ISG15 conjugates. Cell Host & Microbe. 2: 367-9. PMID 18078688 DOI: 10.1016/J.Chom.2007.11.005  0.72
2007 Solis M, Goubau D, Hiscott J. RIG-I has guts: identification of a role for RIG-I in colitis development. Cell Research. 17: 974-5. PMID 18075517 DOI: 10.1038/Cr.2007.107  0.72
2007 Lezin A, Gillet N, Olindo S, Signaté A, Grandvaux N, Verlaeten O, Belrose G, de Carvalho Bittencourt M, Hiscott J, Asquith B, Burny A, Smadja D, Césaire R, Willems L. Histone deacetylase mediated transcriptional activation reduces proviral loads in HTLV-1 associated myelopathy/tropical spastic paraparesis patients. Blood. 110: 3722-8. PMID 17717136 DOI: 10.1182/Blood-2007-04-085076  0.72
2007 Hiscott J. Convergence of the NF-kappaB and IRF pathways in the regulation of the innate antiviral response. Cytokine & Growth Factor Reviews. 18: 483-90. PMID 17706453 DOI: 10.1016/J.Cytogfr.2007.06.002  0.72
2007 Caposio P, Gugliesi F, Zannetti C, Sponza S, Mondini M, Medico E, Hiscott J, Young HA, Gribaudo G, Gariglio M, Landolfo S. A novel role of the interferon-inducible protein IFI16 as inducer of proinflammatory molecules in endothelial cells. The Journal of Biological Chemistry. 282: 33515-29. PMID 17699163 DOI: 10.1074/Jbc.M701846200  0.72
2007 Lemay G, Tumilasci V, Hiscott J. Uncoating reo: uncovering the steps critical for oncolysis. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 1406-7. PMID 17646836 DOI: 10.1038/Sj.Mt.6300242  0.72
2007 Holm GH, Zurney J, Tumilasci V, Leveille S, Danthi P, Hiscott J, Sherry B, Dermody TS. Retinoic acid-inducible gene-I and interferon-beta promoter stimulator-1 augment proapoptotic responses following mammalian reovirus infection via interferon regulatory factor-3. The Journal of Biological Chemistry. 282: 21953-61. PMID 17540767 DOI: 10.1074/Jbc.M702112200  0.72
2007 Zhao T, Yang L, Sun Q, Arguello M, Ballard DW, Hiscott J, Lin R. The NEMO adaptor bridges the nuclear factor-kappaB and interferon regulatory factor signaling pathways. Nature Immunology. 8: 592-600. PMID 17468758 DOI: 10.1038/Ni1465  0.72
2007 Sharif-Askari E, Nakhaei P, Oliere S, Tumilasci V, Hernandez E, Wilkinson P, Lin R, Bell J, Hiscott J. Bax-dependent mitochondrial membrane permeabilization enhances IRF3-mediated innate immune response during VSV infection. Virology. 365: 20-33. PMID 17451770 DOI: 10.1016/J.Virol.2007.03.011  0.72
2007 Hiscott J. Triggering the innate antiviral response through IRF-3 activation. The Journal of Biological Chemistry. 282: 15325-9. PMID 17395583 DOI: 10.1074/Jbc.R700002200  0.72
2007 Solis M, Romieu-Mourez R, Goubau D, Grandvaux N, Mesplede T, Julkunen I, Nardin A, Salcedo M, Hiscott J. Involvement of TBK1 and IKKepsilon in lipopolysaccharide-induced activation of the interferon response in primary human macrophages. European Journal of Immunology. 37: 528-39. PMID 17236232 DOI: 10.1002/Eji.200636090  0.72
2007 Pietilä TE, Veckman V, Lehtonen A, Lin R, Hiscott J, Julkunen I. Multiple NF-kappaB and IFN regulatory factor family transcription factors regulate CCL19 gene expression in human monocyte-derived dendritic cells. Journal of Immunology (Baltimore, Md. : 1950). 178: 253-61. PMID 17182562 DOI: 10.4049/Jimmunol.178.1.253  0.72
2006 Hiscott J, Lin R. Inhibition of the interferon antiviral response by hepatitis C virus. Expert Review of Clinical Immunology. 2: 49-58. PMID 20477087 DOI: 10.1586/1744666X.2.1.49  0.72
2006 Romieu-Mourez R, Solis M, Nardin A, Goubau D, Baron-Bodo V, Lin R, Massie B, Salcedo M, Hiscott J. Distinct roles for IFN regulatory factor (IRF)-3 and IRF-7 in the activation of antitumor properties of human macrophages. Cancer Research. 66: 10576-85. PMID 17079482 DOI: 10.1158/0008-5472.Can-06-1279  0.72
2006 Hiscott J, Nguyen TL, Arguello M, Nakhaei P, Paz S. Manipulation of the nuclear factor-kappaB pathway and the innate immune response by viruses. Oncogene. 25: 6844-67. PMID 17072332 DOI: 10.1038/Sj.Onc.1209941  0.72
2006 Bibeau-Poirier A, Gravel SP, Clément JF, Rolland S, Rodier G, Coulombe P, Hiscott J, Grandvaux N, Meloche S, Servant MJ. Involvement of the IkappaB kinase (IKK)-related kinases tank-binding kinase 1/IKKi and cullin-based ubiquitin ligases in IFN regulatory factor-3 degradation. Journal of Immunology (Baltimore, Md. : 1950). 177: 5059-67. PMID 17015689 DOI: 10.4049/Jimmunol.177.8.5059  0.72
2006 Kaukinen P, Sillanpää M, Kotenko S, Lin R, Hiscott J, Melén K, Julkunen I. Hepatitis C virus NS2 and NS3/4A proteins are potent inhibitors of host cell cytokine/chemokine gene expression. Virology Journal. 3: 66. PMID 16945160 DOI: 10.1186/1743-422X-3-66  0.72
2006 Paz S, Sun Q, Nakhaei P, Romieu-Mourez R, Goubau D, Julkunen I, Lin R, Hiscott J. Induction of IRF-3 and IRF-7 phosphorylation following activation of the RIG-I pathway. Cellular and Molecular Biology (Noisy-Le-Grand, France). 52: 17-28. PMID 16914100  0.72
2006 Harris J, Olière S, Sharma S, Sun Q, Lin R, Hiscott J, Grandvaux N. Nuclear accumulation of cRel following C-terminal phosphorylation by TBK1/IKK epsilon. Journal of Immunology (Baltimore, Md. : 1950). 177: 2527-35. PMID 16888014 DOI: 10.4049/Jimmunol.177.4.2527  0.72
2006 Hiscott J, Lacoste J, Lin R. Recruitment of an interferon molecular signaling complex to the mitochondrial membrane: disruption by hepatitis C virus NS3-4A protease. Biochemical Pharmacology. 72: 1477-84. PMID 16876765 DOI: 10.1016/J.Bcp.2006.06.030  0.72
2006 Solis M, Goubau D, Romieu-Mourez R, Genin P, Civas A, Hiscott J. Distinct functions of IRF-3 and IRF-7 in IFN-alpha gene regulation and control of anti-tumor activity in primary macrophages. Biochemical Pharmacology. 72: 1469-76. PMID 16846591 DOI: 10.1016/J.Bcp.2006.06.002  0.72
2006 Sirén J, Imaizumi T, Sarkar D, Pietilä T, Noah DL, Lin R, Hiscott J, Krug RM, Fisher PB, Julkunen I, Matikainen S. Retinoic acid inducible gene-I and mda-5 are involved in influenza A virus-induced expression of antiviral cytokines. Microbes and Infection / Institut Pasteur. 8: 2013-20. PMID 16797201 DOI: 10.1016/J.Micinf.2006.02.028  0.72
2006 Lin R, Lacoste J, Nakhaei P, Sun Q, Yang L, Paz S, Wilkinson P, Julkunen I, Vitour D, Meurs E, Hiscott J. Dissociation of a MAVS/IPS-1/VISA/Cardif-IKKepsilon molecular complex from the mitochondrial outer membrane by hepatitis C virus NS3-4A proteolytic cleavage. Journal of Virology. 80: 6072-83. PMID 16731946 DOI: 10.1128/Jvi.02495-05  0.72
2006 Solis M, Wilkinson P, Romieu R, Hernandez E, Wainberg MA, Hiscott J. Gene expression profiling of the host response to HIV-1 B, C, or A/E infection in monocyte-derived dendritic cells. Virology. 352: 86-99. PMID 16730773 DOI: 10.1016/J.Virol.2006.04.010  0.72
2006 Arguello M, Paz S, Hernandez E, Corriveau-Bourque C, Fawaz LM, Hiscott J, Lin R. Leukotriene A4 hydrolase expression in PEL cells is regulated at the transcriptional level and leads to increased leukotriene B4 production. Journal of Immunology (Baltimore, Md. : 1950). 176: 7051-61. PMID 16709867 DOI: 10.4049/Jimmunol.176.11.7051  0.72
2006 Matikainen S, Sirén J, Tissari J, Veckman V, Pirhonen J, Severa M, Sun Q, Lin R, Meri S, Uzé G, Hiscott J, Julkunen I. Tumor necrosis factor alpha enhances influenza A virus-induced expression of antiviral cytokines by activating RIG-I gene expression. Journal of Virology. 80: 3515-22. PMID 16537619 DOI: 10.1128/Jvi.80.7.3515-3522.2006  0.72
2006 Berro R, Kehn K, de la Fuente C, Pumfery A, Adair R, Wade J, Colberg-Poley AM, Hiscott J, Kashanchi F. Acetylated Tat regulates human immunodeficiency virus type 1 splicing through its interaction with the splicing regulator p32. Journal of Virology. 80: 3189-204. PMID 16537587 DOI: 10.1128/Jvi.80.7.3189-3204.2006  0.72
2006 Hiscott J, Lin R, Nakhaei P, Paz S. MasterCARD: a priceless link to innate immunity. Trends in Molecular Medicine. 12: 53-6. PMID 16406812 DOI: 10.1016/J.Molmed.2005.12.003  0.72
2006 Civas A, Génin P, Morin P, Lin R, Hiscott J. Promoter organization of the interferon-A genes differentially affects virus-induced expression and responsiveness to TBK1 and IKKepsilon. The Journal of Biological Chemistry. 281: 4856-66. PMID 16380379 DOI: 10.1074/Jbc.M506812200  0.72
2006 Bannwarth S, Lainé S, Daher A, Grandvaux N, Clerzius G, Leblanc AC, Hiscott J, Gatignol A. Cell-specific regulation of TRBP1 promoter by NF-Y transcription factor in lymphocytes and astrocytes. Journal of Molecular Biology. 355: 898-910. PMID 16343534 DOI: 10.1016/J.Jmb.2005.11.026  0.72
2006 Lin R, Yang L, Nakhaei P, Sun Q, Sharif-Askari E, Julkunen I, Hiscott J. Negative regulation of the retinoic acid-inducible gene I-induced antiviral state by the ubiquitin-editing protein A20. The Journal of Biological Chemistry. 281: 2095-103. PMID 16306043 DOI: 10.1074/Jbc.M510326200  0.72
2006 Césaire R, Olière S, Sharif-Askari E, Loignon M, Lézin A, Olindo S, Panelatti G, Kazanji M, Aloyz R, Panasci L, Bell JC, Hiscott J. Oncolytic activity of vesicular stomatitis virus in primary adult T-cell leukemia. Oncogene. 25: 349-58. PMID 16186807 DOI: 10.1038/Sj.Onc.1209055  0.72
2006 Nakhaei P, Paz S, Hiscott J. Activation of Interferon Gene Expression Through Toll-like Receptor-dependent and -independent Pathways The Interferons: Characterization and Application. 35-72. DOI: 10.1002/3527608206.ch2  0.72
2005 Pickell L, Tran P, Leclerc D, Hiscott J, Rozen R. Regulatory studies of murine methylenetetrahydrofolate reductase reveal two major promoters and NF-kappaB sensitivity. Biochimica Et Biophysica Acta. 1731: 104-14. PMID 16274753 DOI: 10.1016/J.Bbaexp.2005.09.002  0.72
2005 Hiscott J, Lin R. IRF-3 releases its inhibitions. Structure (London, England : 1993). 13: 1235-6. PMID 16154077 DOI: 10.1016/J.Str.2005.08.001  0.72
2005 Setiadi AF, David MD, Chen SS, Hiscott J, Jefferies WA. Identification of mechanisms underlying transporter associated with antigen processing deficiency in metastatic murine carcinomas. Cancer Research. 65: 7485-92. PMID 16103103 DOI: 10.1158/0008-5472.Can-03-3734  0.72
2005 Osterlund P, Veckman V, Sirén J, Klucher KM, Hiscott J, Matikainen S, Julkunen I. Gene expression and antiviral activity of alpha/beta interferons and interleukin-29 in virus-infected human myeloid dendritic cells. Journal of Virology. 79: 9608-17. PMID 16014923 DOI: 10.1128/Jvi.79.15.9608-9617.2005  0.72
2005 Desfosses Y, Solis M, Sun Q, Grandvaux N, Van Lint C, Burny A, Gatignol A, Wainberg MA, Lin R, Hiscott J. Regulation of human immunodeficiency virus type 1 gene expression by clade-specific Tat proteins. Journal of Virology. 79: 9180-91. PMID 15994812 DOI: 10.1128/Jvi.79.14.9180-9191.2005  0.72
2005 Grandvaux N, Gaboriau F, Harris J, tenOever BR, Lin R, Hiscott J. Regulation of arginase II by interferon regulatory factor 3 and the involvement of polyamines in the antiviral response. The Febs Journal. 272: 3120-31. PMID 15955070 DOI: 10.1111/J.1742-4658.2005.04726.X  0.72
2005 Gautier G, Humbert M, Deauvieau F, Scuiller M, Hiscott J, Bates EE, Trinchieri G, Caux C, Garrone P. A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells. The Journal of Experimental Medicine. 201: 1435-46. PMID 15851485 DOI: 10.1084/jem.20041964  0.72
2005 Breiman A, Grandvaux N, Lin R, Ottone C, Akira S, Yoneyama M, Fujita T, Hiscott J, Meurs EF. Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKepsilon. Journal of Virology. 79: 3969-78. PMID 15767399 DOI: 10.1128/Jvi.79.7.3969-3978.2005  0.72
2005 Mamane Y, Loignon M, Palmer J, Hernandez E, Césaire R, Alaoui-Jamali M, Hiscott J. Repression of DNA repair mechanisms in IRF-4-expressing and HTLV-I-infected T lymphocytes. Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research. 25: 43-51. PMID 15684621 DOI: 10.1089/Jir.2005.25.43  0.72
2005 Lin R, Yang L, Arguello M, Penafuerte C, Hiscott J. A CRM1-dependent nuclear export pathway is involved in the regulation of IRF-5 subcellular localization. The Journal of Biological Chemistry. 280: 3088-95. PMID 15556946 DOI: 10.1074/Jbc.M408452200  0.72
2004 Hiscott J. Another detour on the Toll road to the interferon antiviral response. Nature Structural & Molecular Biology. 11: 1028-30. PMID 15523474 DOI: 10.1038/Nsmb1104-1028  0.72
2004 tenOever BR, Sharma S, Zou W, Sun Q, Grandvaux N, Julkunen I, Hemmi H, Yamamoto M, Akira S, Yeh WC, Lin R, Hiscott J. Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity. Journal of Virology. 78: 10636-49. PMID 15367631 DOI: 10.1128/Jvi.78.19.10636-10649.2004  0.72
2004 Miller K, McArdle S, Gale MJ, Geller DA, Tenoever B, Hiscott J, Gretch DR, Polyak SJ. Effects of the hepatitis C virus core protein on innate cellular defense pathways. Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research. 24: 391-402. PMID 15296650 DOI: 10.1089/1079990041535647  0.72
2004 Sgarbanti M, Arguello M, tenOever BR, Battistini A, Lin R, Hiscott J. A requirement for NF-kappaB induction in the production of replication-competent HHV-8 virions. Oncogene. 23: 5770-80. PMID 15235582 DOI: 10.1038/Sj.Onc.1207707  0.72
2003 Hiscott J, Grandvaux N, Sharma S, Tenoever BR, Servant MJ, Lin R. Convergence of the NF-kappaB and interferon signaling pathways in the regulation of antiviral defense and apoptosis. Annals of the New York Academy of Sciences. 1010: 237-48. PMID 15033728 DOI: 10.1196/Annals.1299.042  0.72
2003 Stojdl DF, Lichty BD, tenOever BR, Paterson JM, Power AT, Knowles S, Marius R, Reynard J, Poliquin L, Atkins H, Brown EG, Durbin RK, Durbin JE, Hiscott J, Bell JC. VSV strains with defects in their ability to shutdown innate immunity are potent systemic anti-cancer agents. Cancer Cell. 4: 263-75. PMID 14585354 DOI: 10.1016/S1535-6108(03)00241-1  0.72
2003 Battisti PL, Daher A, Bannwarth S, Voortman J, Peden KW, Hiscott J, Mouland AJ, Benarous R, Gatignol A. Additive activity between the trans-activation response RNA-binding protein, TRBP2, and cyclin T1 on HIV type 1 expression and viral production in murine cells. Aids Research and Human Retroviruses. 19: 767-78. PMID 14585207 DOI: 10.1089/088922203769232566  0.72
2003 Ehrhardt H, Fulda S, Schmid I, Hiscott J, Debatin KM, Jeremias I. TRAIL induced survival and proliferation in cancer cells resistant towards TRAIL-induced apoptosis mediated by NF-kappaB. Oncogene. 22: 3842-52. PMID 12813457 DOI: 10.1038/Sj.Onc.1206520  0.72
2003 Sharma S, tenOever BR, Grandvaux N, Zhou GP, Lin R, Hiscott J. Triggering the interferon antiviral response through an IKK-related pathway. Science (New York, N.Y.). 300: 1148-51. PMID 12702806 DOI: 10.1126/Science.1081315  0.72
2003 Bramson JL, Dayball K, Hall JR, Millar JB, Miller M, Wan YH, Lin R, Hiscott J. Super-activated interferon-regulatory factors can enhance plasmid immunization. Vaccine. 21: 1363-70. PMID 12615431 DOI: 10.1016/S0264-410X(02)00694-1  0.72
2003 Arguello M, Sgarbanti M, Hernandez E, Mamane Y, Sharma S, Servant M, Lin R, Hiscott J. Disruption of the B-cell specific transcriptional program in HHV-8 associated primary effusion lymphoma cell lines. Oncogene. 22: 964-73. PMID 12592383 DOI: 10.1038/Sj.Onc.1206270  0.72
2003 Servant MJ, Grandvaux N, tenOever BR, Duguay D, Lin R, Hiscott J. Identification of the minimal phosphoacceptor site required for in vivo activation of interferon regulatory factor 3 in response to virus and double-stranded RNA. The Journal of Biological Chemistry. 278: 9441-7. PMID 12524442 DOI: 10.1074/Jbc.M209851200  0.72
2002 Baetu TM, Hiscott J. On the TRAIL to apoptosis. Cytokine & Growth Factor Reviews. 13: 199-207. PMID 12486874 DOI: 10.1016/S1359-6101(02)00006-0  0.72
2002 Mamane Y, Grandvaux N, Hernandez E, Sharma S, Innocente SA, Lee JM, Azimi N, Lin R, Hiscott J. Repression of IRF-4 target genes in human T cell leukemia virus-1 infection. Oncogene. 21: 6751-65. PMID 12360402 DOI: 10.1038/Sj.Onc.1205843  0.72
2002 Duguay D, Mercier F, Stagg J, Martineau D, Bramson J, Servant M, Lin R, Galipeau J, Hiscott J. In vivo interferon regulatory factor 3 tumor suppressor activity in B16 melanoma tumors. Cancer Research. 62: 5148-52. PMID 12234977  0.72
2002 Sharma S, Grandvaux N, Mamane Y, Genin P, Azimi N, Waldmann T, Hiscott J. Regulation of IFN regulatory factor 4 expression in human T cell leukemia virus-I-transformed T cells. Journal of Immunology (Baltimore, Md. : 1950). 169: 3120-30. PMID 12218129 DOI: 10.4049/Jimmunol.169.6.3120  0.72
2002 Servant MJ, Grandvaux N, Hiscott J. Multiple signaling pathways leading to the activation of interferon regulatory factor 3. Biochemical Pharmacology. 64: 985-92. PMID 12213596 DOI: 10.1016/S0006-2952(02)01165-6  0.72
2002 Roof P, Ricci M, Genin P, Montano MA, Essex M, Wainberg MA, Gatignol A, Hiscott J. Differential regulation of HIV-1 clade-specific B, C, and E long terminal repeats by NF-kappaB and the Tat transactivator. Virology. 296: 77-83. PMID 12036319 DOI: 10.1006/Viro.2001.1397  0.72
2002 Mariner JM, Mamane Y, Hiscott J, Waldmann TA, Azimi N. IFN regulatory factor 4 participates in the human T cell lymphotropic virus type I-mediated activation of the IL-15 receptor alpha promoter. Journal of Immunology (Baltimore, Md. : 1950). 168: 5667-74. PMID 12023365 DOI: 10.4049/Jimmunol.168.11.5667  0.72
2002 Grandvaux N, tenOever BR, Servant MJ, Hiscott J. The interferon antiviral response: from viral invasion to evasion. Current Opinion in Infectious Diseases. 15: 259-67. PMID 12015460 DOI: 10.1097/00001432-200206000-00008  0.72
2002 Grandvaux N, Servant MJ, tenOever B, Sen GC, Balachandran S, Barber GN, Lin R, Hiscott J. Transcriptional profiling of interferon regulatory factor 3 target genes: direct involvement in the regulation of interferon-stimulated genes. Journal of Virology. 76: 5532-9. PMID 11991981 DOI: 10.1128/Jvi.76.11.5532-5539.2002  0.72
2002 tenOever BR, Servant MJ, Grandvaux N, Lin R, Hiscott J. Recognition of the measles virus nucleocapsid as a mechanism of IRF-3 activation. Journal of Virology. 76: 3659-69. PMID 11907205 DOI: 10.1128/Jvi.76.8.3659-3669.2002  0.72
2002 Morin P, Bragança J, Bandu MT, Lin R, Hiscott J, Doly J, Civas A. Preferential binding sites for interferon regulatory factors 3 and 7 involved in interferon-A gene transcription. Journal of Molecular Biology. 316: 1009-22. PMID 11884139 DOI: 10.1006/Jmbi.2001.5401  0.72
2002 Mamane Y, Sharma S, Grandvaux N, Hernandez E, Hiscott J. IRF-4 activities in HTLV-I-induced T cell leukemogenesis. Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research. 22: 135-43. PMID 11846984 DOI: 10.1089/107999002753452746  0.72
2002 Battistini A, Marsili G, Sgarbanti M, Ensoli B, Hiscott J. IRF regulation of HIV-1 long terminal repeat activity. Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research. 22: 27-37. PMID 11846973 DOI: 10.1089/107999002753452638  0.72
2002 Hiscott J, Pitha PM. Interferon regulatory factors: Bridging antiviral defense, growth control, and immunoregulation Journal of Interferon and Cytokine Research. 22: 3-4. DOI: 10.1089/107999002753452601  0.72
2001 Coccia EM, Stellacci E, Valtieri M, Masella B, Feccia T, Marziali G, Hiscott J, Testa U, Peschle C, Battistini A. Ectopic expression of interferon regulatory factor-1 potentiates granulocytic differentiation. The Biochemical Journal. 360: 285-94. PMID 11716756 DOI: 10.1042/Bj3600285  0.72
2001 Nathens AB, Bitar R, Marshall JC, Watson RW, Dackiw AP, Fan J, Hiscott J, Rotstein OD. Antioxidants increase lipopolysaccharide-stimulated TNF alpha release in murine macrophages: role for altered TNF alpha mRNA stability. Shock (Augusta, Ga.). 16: 361-7. PMID 11699074 DOI: 10.1097/00024382-200116050-00007  0.72
2001 Bannwarth S, Talakoub L, Letourneur F, Duarte M, Purcell DF, Hiscott J, Gatignol A. Organization of the human tarbp2 gene reveals two promoters that are repressed in an astrocytic cell line. The Journal of Biological Chemistry. 276: 48803-13. PMID 11641396 DOI: 10.1074/Jbc.M104645200  0.72
2001 Baetu TM, Kwon H, Sharma S, Grandvaux N, Hiscott J. Disruption of NF-kappaB signaling reveals a novel role for NF-kappaB in the regulation of TNF-related apoptosis-inducing ligand expression. Journal of Immunology (Baltimore, Md. : 1950). 167: 3164-73. PMID 11544302 DOI: 10.4049/Jimmunol.167.6.3164  0.72
2001 Le Page C, Popescu O, Génin P, Lian J, Paquin A, Galipeau J, Hiscott J. Disruption of NF-kappa B signaling and chemokine gene activation by retroviral mediated expression of IKK gamma/NEMO mutants. Virology. 286: 422-33. PMID 11485410 DOI: 10.1006/Viro.2001.0999  0.72
2001 Hiscott J. Introduction--cytokine receptors, signaling pathways and viruses. Cytokine & Growth Factor Reviews. 12: 129-31. PMID 11325596 DOI: 10.1016/S1359-6101(00)00036-8  0.72
2001 Lin R, Genin P, Mamane Y, Sgarbanti M, Battistini A, Harrington WJ, Barber GN, Hiscott J. HHV-8 encoded vIRF-1 represses the interferon antiviral response by blocking IRF-3 recruitment of the CBP/p300 coactivators. Oncogene. 20: 800-11. PMID 11314014 DOI: 10.1038/Sj.Onc.1204163  0.72
2001 Ishii T, Kwon H, Hiscott J, Mosialos G, Koromilas AE. Activation of the I kappa B alpha kinase (IKK) complex by double-stranded RNA-binding defective and catalytic inactive mutants of the interferon-inducible protein kinase PKR. Oncogene. 20: 1900-12. PMID 11313938 DOI: 10.1038/Sj.Onc.1204267  0.72
2001 Hiscott J, Kwon H, Génin P. Hostile takeovers: viral appropriation of the NF-kappaB pathway. The Journal of Clinical Investigation. 107: 143-51. PMID 11160127 DOI: 10.1172/Jci11918  0.72
2001 Servant MJ, ten Oever B, LePage C, Conti L, Gessani S, Julkunen I, Lin R, Hiscott J. Identification of distinct signaling pathways leading to the phosphorylation of interferon regulatory factor 3. The Journal of Biological Chemistry. 276: 355-63. PMID 11035028 DOI: 10.1074/jbc.M007790200  0.72
2000 Le Page C, Génin P, Baines MG, Hiscott J. Interferon activation and innate immunity. Reviews in Immunogenetics. 2: 374-86. PMID 11256746  0.72
2000 Sharma S, Mamane Y, Grandvaux N, Bartlett J, Petropoulos L, Lin R, Hiscott J. Activation and regulation of interferon regulatory factor 4 in HTLV type 1-infected T lymphocytes. Aids Research and Human Retroviruses. 16: 1613-22. PMID 11080800 DOI: 10.1089/08892220050193047  0.72
2000 Lin R, Génin P, Mamane Y, Hiscott J. Selective DNA binding and association with the CREB binding protein coactivator contribute to differential activation of alpha/beta interferon genes by interferon regulatory factors 3 and 7. Molecular and Cellular Biology. 20: 6342-53. PMID 10938111 DOI: 10.1128/Mcb.20.17.6342-6353.2000  0.72
2000 Sancéau J, Hiscott J, Delattre O, Wietzerbin J. IFN-beta induces serine phosphorylation of Stat-1 in Ewing's sarcoma cells and mediates apoptosis via induction of IRF-1 and activation of caspase-7. Oncogene. 19: 3372-83. PMID 10918594 DOI: 10.1038/Sj.Onc.1203670  0.72
2000 Lin R, Mamane Y, Hiscott J. Multiple regulatory domains control IRF-7 activity in response to virus infection. The Journal of Biological Chemistry. 275: 34320-7. PMID 10893229 DOI: 10.1074/Jbc.M002814200  0.72
2000 Génin P, Algarté M, Roof P, Lin R, Hiscott J. Regulation of RANTES chemokine gene expression requires cooperativity between NF-kappa B and IFN-regulatory factor transcription factors. Journal of Immunology (Baltimore, Md. : 1950). 164: 5352-61. PMID 10799898 DOI: 10.4049/Jimmunol.164.10.5352  0.72
2000 Heylbroeck C, Balachandran S, Servant MJ, DeLuca C, Barber GN, Lin R, Hiscott J. The IRF-3 transcription factor mediates Sendai virus-induced apoptosis. Journal of Virology. 74: 3781-92. PMID 10729153 DOI: 10.1128/Jvi.74.8.3781-3792.2000  0.72
2000 Mamane Y, Sharma S, Petropoulos L, Lin R, Hiscott J. Posttranslational regulation of IRF-4 activity by the immunophilin FKBP52. Immunity. 12: 129-40. PMID 10714679 DOI: 10.1016/S1074-7613(00)80166-1  0.72
1999 DeLuca C, Kwon H, Lin R, Wainberg M, Hiscott J. NF-kappaB activation and HIV-1 induced apoptosis. Cytokine & Growth Factor Reviews. 10: 235-53. PMID 10647779 DOI: 10.1016/S1359-6101(99)00015-5  0.72
1999 Mamane Y, Heylbroeck C, Génin P, Algarté M, Servant MJ, LePage C, DeLuca C, Kwon H, Lin R, Hiscott J. Interferon regulatory factors: the next generation. Gene. 237: 1-14. PMID 10524230 DOI: 10.1016/S0378-1119(99)00262-0  0.72
1999 Nguyen H, Teskey L, Lin R, Hiscott J. Identification of the secretory leukocyte protease inhibitor (SLPI) as a target of IRF-1 regulation. Oncogene. 18: 5455-63. PMID 10498899 DOI: 10.1038/Sj.Onc.1202924  0.72
1999 Génin P, Mamane Y, Kwon H, LePage C, Wainberg MA, Hiscott J. Differential regulation of CC chemokine gene expression in human immunodeficiency virus-infected myeloid cells. Virology. 261: 205-15. PMID 10497106 DOI: 10.1006/Viro.1999.9852  0.72
1999 Algarté M, Kwon H, Génin P, Hiscott J. Identification by in vivo genomic footprinting of a transcriptional switch containing NF-kappaB and Sp1 that regulates the IkappaBalpha promoter. Molecular and Cellular Biology. 19: 6140-53. PMID 10454561 DOI: 10.1128/Mcb.19.9.6140  0.72
1999 Crinelli R, Bianchi M, Gentilini L, Magnani M, Hiscott J. Activation of the ubiquitin proteolytic system in murine acquired immunodeficiency syndrome affects IkappaBalpha turnover. European Journal of Biochemistry / Febs. 263: 202-11. PMID 10429205 DOI: 10.1046/J.1432-1327.1999.00485.X  0.72
1999 Juang YT, Au WC, Lowther W, Hiscott J, Pitha PM. Lipopolysaccharide inhibits virus-mediated induction of interferon genes by disruption of nuclear transport of interferon regulatory factors 3 and 7. The Journal of Biological Chemistry. 274: 18060-6. PMID 10364258 DOI: 10.1074/jbc.274.25.18060  0.72
1999 Coccia EM, Del Russo N, Stellacci E, Orsatti R, Benedetti E, Marziali G, Hiscott J, Battistini A. Activation and repression of the 2-5A synthetase and p21 gene promoters by IRF-1 and IRF-2. Oncogene. 18: 2129-37. PMID 10321737 DOI: 10.1038/Sj.Onc.1202536  0.72
1999 Percario ZA, Giandomenico V, Fiorucci G, Chiantore MV, Vannucchi S, Hiscott J, Affabris E, Romeo G. Retinoic acid is able to induce interferon regulatory factor 1 in squamous carcinoma cells via a STAT-1 independent signalling pathway. Cell Growth & Differentiation : the Molecular Biology Journal of the American Association For Cancer Research. 10: 263-70. PMID 10319996  0.72
1999 DeLuca C, Petropoulos L, Zmeureanu D, Hiscott J. Nuclear IkappaBbeta maintains persistent NF-kappaB activation in HIV-1-infected myeloid cells. The Journal of Biological Chemistry. 274: 13010-6. PMID 10224051 DOI: 10.1074/Jbc.274.19.13010  0.72
1999 Lin R, Hiscott J. A role for casein kinase II phosphorylation in the regulation of IRF-1 transcriptional activity. Molecular and Cellular Biochemistry. 191: 169-80. PMID 10094406 DOI: 10.1023/A:1006850009017  0.72
1999 Lin R, Mamane Y, Hiscott J. Structural and functional analysis of interferon regulatory factor 3: localization of the transactivation and autoinhibitory domains. Molecular and Cellular Biology. 19: 2465-74. PMID 10082512 DOI: 10.1128/Mcb.19.4.2465  0.72
1999 Algarté M, Nguyen H, Heylbroeck C, Lin R, Hiscott J. IkappaB-mediated inhibition of virus-induced beta interferon transcription. Journal of Virology. 73: 2694-702. PMID 10074115 DOI: 10.1128/Jvi.73.4.2694-2702.1999  0.72
1999 Hiscott J, Pitha P, Genin P, Nguyen H, Heylbroeck C, Mamane Y, Algarte M, Lin R. Triggering the interferon response: the role of IRF-3 transcription factor. Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research. 19: 1-13. PMID 10048763 DOI: 10.1089/107999099314360  0.72
1999 Spencer W, Kwon H, Crépieux P, Leclerc N, Lin R, Hiscott J. Taxol selectively blocks microtubule dependent NF-kappaB activation by phorbol ester via inhibition of IkappaBalpha phosphorylation and degradation. Oncogene. 18: 495-505. PMID 9927206 DOI: 10.1038/Sj.Onc.1202335  0.72
1999 Lin R, Heylbroeck C, Genin P, Pitha PM, Hiscott J. Essential role of interferon regulatory factor 3 in direct activation of RANTES chemokine transcription. Molecular and Cellular Biology. 19: 959-66. PMID 9891032 DOI: 10.1128/Mcb.19.2.959  0.72
1999 Algarté M, Nguyen H, Heylbroeck C, Lin R, Hiscott J. IκB-mediated inhibition of virus-induced beta interferon transcription Journal of Virology. 73: 2694-2702.  0.72
1998 Petropoulos L, Hiscott J. Association between HTLV-1 Tax and I kappa B alpha is dependent on the I kappa B alpha phosphorylation state. Virology. 252: 189-99. PMID 9875328 DOI: 10.1006/Viro.1998.9430  0.72
1998 Pitha PM, Au WC, Lowther W, Juang YT, Schafer SL, Burysek L, Hiscott J, Moore PA. Role of the interferon regulatory factors (IRFs) in virus-mediated signaling and regulation of cell growth. Biochimie. 80: 651-8. PMID 9865487 DOI: 10.1016/S0300-9084(99)80018-2  0.72
1998 Juang YT, Lowther W, Kellum M, Au WC, Lin R, Hiscott J, Pitha PM. Primary activation of interferon A and interferon B gene transcription by interferon regulatory factor 3. Proceedings of the National Academy of Sciences of the United States of America. 95: 9837-42. PMID 9707562 DOI: 10.1073/Pnas.95.17.9837  0.72
1998 Dionne S, D'Agata ID, Hiscott J, Vanounou T, Seidman EG. Colonic explant production of IL-1and its receptor antagonist is imbalanced in inflammatory bowel disease (IBD). Clinical and Experimental Immunology. 112: 435-42. PMID 9649212 DOI: 10.1046/j.1365-2249.1998.00595.x  0.72
1998 DeLuca C, Kwon H, Pelletier N, Wainberg MA, Hiscott J. NF-kappaB protects HIV-1-infected myeloid cells from apoptosis. Virology. 244: 27-38. PMID 9581775 DOI: 10.1006/Viro.1998.9085  0.72
1998 Dehbi M, Hiscott J, Pelletier J. Activation of the wt1 Wilms' tumor suppressor gene by NF-kappaB. Oncogene. 16: 2033-9. PMID 9572484 DOI: 10.1038/Sj.Onc.1201747  0.72
1998 Lin R, Heylbroeck C, Pitha PM, Hiscott J. Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation. Molecular and Cellular Biology. 18: 2986-96. PMID 9566918 DOI: 10.1128/Mcb.18.5.2986  0.72
1998 Kwon H, Pelletier N, DeLuca C, Genin P, Cisternas S, Lin R, Wainberg MA, Hiscott J. Inducible expression of IkappaBalpha repressor mutants interferes with NF-kappaB activity and HIV-1 replication in Jurkat T cells. The Journal of Biological Chemistry. 273: 7431-40. PMID 9516441 DOI: 10.1074/Jbc.273.13.7431  0.72
1998 Schafer SL, Lin R, Moore PA, Hiscott J, Pitha PM. Regulation of type I interferon gene expression by interferon regulatory factor-3. The Journal of Biological Chemistry. 273: 2714-20. PMID 9446577 DOI: 10.1074/jbc.273.5.2714  0.72
1997 Nguyen H, Hiscott J, Pitha PM. The growing family of interferon regulatory factors. Cytokine & Growth Factor Reviews. 8: 293-312. PMID 9620643 DOI: 10.1016/S1359-6101(97)00019-1  0.72
1997 Faggioli L, Merola M, Hiscott J, Furia A, Monese R, Tovey M, Palmieri M. Molecular mechanisms regulating induction of interleukin-6 gene transcription by interferon-gamma. European Journal of Immunology. 27: 3022-30. PMID 9394833 DOI: 10.1002/Eji.1830271140  0.72
1997 Crépieux P, Kwon H, Leclerc N, Spencer W, Richard S, Lin R, Hiscott J. I kappaB alpha physically interacts with a cytoskeleton-associated protein through its signal response domain. Molecular and Cellular Biology. 17: 7375-85. PMID 9372968 DOI: 10.1128/Mcb.17.12.7375  0.72
1997 Nguyen H, Lin R, Hiscott J. Activation of multiple growth regulatory genes following inducible expression of IRF-1 or IRF/RelA fusion proteins. Oncogene. 15: 1425-35. PMID 9333018 DOI: 10.1038/Sj.Onc.1201318  0.72
1997 Liang C, Li X, Quan Y, Laughrea M, Kleiman L, Hiscott J, Wainberg MA. Sequence elements downstream of the human immunodeficiency virus type 1 long terminal repeat are required for efficient viral gene transcription. Journal of Molecular Biology. 272: 167-77. PMID 9299345 DOI: 10.1006/Jmbi.1997.1239  0.72
1997 Lee R, Beauparlant P, Elford H, Ponka P, Hiscott J. Selective inhibition of l kappaB alpha phosphorylation and HIV-1 LTR-directed gene expression by novel antioxidant compounds. Virology. 234: 277-90. PMID 9268159 DOI: 10.1006/Viro.1997.8642  0.72
1997 Dionne S, Hiscott J, D'Agata I, Duhaime A, Seidman EG. Quantitative PCR analysis of TNF-alpha and IL-1 beta mRNA levels in pediatric IBD mucosal biopsies. Digestive Diseases and Sciences. 42: 1557-66. PMID 9246063 DOI: 10.1023/A:1018895500721  0.72
1997 Hiscott J, Beauparlant P, Crepieux P, DeLuca C, Kwon H, Lin R, Petropoulos L. Cellular and viral protein interactions regulating I kappa B alpha activity during human retrovirus infection. Journal of Leukocyte Biology. 62: 82-92. PMID 9225998 DOI: 10.1002/Jlb.62.1.82  0.72
1997 Conti L, Hiscott J, Papacchini M, Roulston A, Wainberg MA, Belardelli F, Gessani S. Induction of relA(p65) and I kappa B alpha subunit expression during differentiation of human peripheral blood monocytes to macrophages. Cell Growth & Differentiation : the Molecular Biology Journal of the American Association For Cancer Research. 8: 435-42. PMID 9101089  0.72
1997 Aoudjit F, Brochu N, Bélanger B, Stratowa C, Hiscott J, Audette M. Regulation of intercellular adhesion molecule-1 gene by tumor necrosis factor-alpha is mediated by the nuclear factor-kappaB heterodimers p65/p65 and p65/c-Rel in the absence of p50. Cell Growth & Differentiation : the Molecular Biology Journal of the American Association For Cancer Research. 8: 335-42. PMID 9056676  0.72
1997 Nagai K, Wong AH, Li S, Tam WN, Cuddihy AR, Sonenberg N, Mathews MB, Hiscott J, Wainberg MA, Koromilas AE. Induction of CD4 expression and human immunodeficiency virus type 1 replication by mutants of the interferon-inducible protein kinase PKR. Journal of Virology. 71: 1718-25. PMID 8995707 DOI: 10.1128/Jvi.71.2.1718-1725.1997  0.72
1996 Petropoulos L, Lin R, Hiscott J. Human T cell leukemia virus type 1 tax protein increases NF-kappa B dimer formation and antagonizes the inhibitory activity of the I kappa B alpha regulatory protein. Virology. 225: 52-64. PMID 8918533 DOI: 10.1006/Viro.1996.0574  0.72
1996 Schafer SL, Hiscott J, Pitha PM. Differential regulation of the HIV-1 LTR by specific NF-kappa B subunits in HSV-1-infected cells. Virology. 224: 214-23. PMID 8862416 DOI: 10.1006/Viro.1996.0523  0.72
1996 DeLuca C, Roulston A, Koromilas A, Wainberg MA, Hiscott J. Chronic human immunodeficiency virus type 1 infection of myeloid cells disrupts the autoregulatory control of the NF-kappaB/Rel pathway via enhanced IkappaBalpha degradation. Journal of Virology. 70: 5183-93. PMID 8764027 DOI: 10.1128/Jvi.70.8.5183-5193.1996  0.4
1996 Beauparlant P, Kwon H, Clarke M, Lin R, Sonenberg N, Wainberg M, Hiscott J. Transdominant mutants of I kappa B alpha block Tat-tumor necrosis factor synergistic activation of human immunodeficiency virus type 1 gene expression and virus multiplication. Journal of Virology. 70: 5777-85. PMID 8709193 DOI: 10.1128/Jvi.70.9.5777-5785.1996  0.72
1996 Lin R, Beauparlant P, Makris C, Meloche S, Hiscott J. Phosphorylation of IkappaBalpha in the C-terminal PEST domain by casein kinase II affects intrinsic protein stability. Molecular and Cellular Biology. 16: 1401-9. PMID 8657113 DOI: 10.1128/Mcb.16.4.1401  0.72
1996 Beauparlant P, Lin R, Hiscott J. The role of the C-terminal domain of I kappa B alpha in protein degradation and stabilization. The Journal of Biological Chemistry. 271: 10690-6. PMID 8631876 DOI: 10.1074/Jbc.271.18.10690  0.72
1995 McKiel V, Gu Z, Wainberg MA, Hiscott J. Inhibition of human immunodeficiency virus type 1 multiplication by transforming growth factor beta 1 and AZT in HIV-1-infected myeloid cells. Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research. 15: 849-55. PMID 8564706 DOI: 10.1089/Jir.1995.15.849  0.36
1995 Bitar R, Beauparlant P, Lin R, Pitha P, Hiscott J. Retrovirus-mediated transfer of nuclear factor-kappa B subunit genes modulates I kappa B alpha and interferon beta expression. Cell Growth & Differentiation : the Molecular Biology Journal of the American Association For Cancer Research. 6: 965-76. PMID 8547225  0.72
1995 Hiscott J, Petropoulos L, Lacoste J. Molecular interactions between HTLV-1 Tax protein and the NF-kappa B/kappa B transcription complex. Virology. 214: 3-11. PMID 8525633 DOI: 10.1006/Viro.1995.9960  0.48
1995 Lacoste J, Petropoulos L, Pépin N, Hiscott J. Constitutive phosphorylation and turnover of I kappa B alpha in human T-cell leukemia virus type I-infected and Tax-expressing T cells. Journal of Virology. 69: 564-9. PMID 7983756 DOI: 10.1128/Jvi.69.1.564-569.1995  0.48
1995 Lin R, Gewert D, Hiscott J. Differential transcriptional activation in vitro by NF-kappa B/Rel proteins. The Journal of Biological Chemistry. 270: 3123-31. PMID 7852394 DOI: 10.1074/Jbc.270.7.3123  0.72
1995 Nguyen H, Mustafa A, Hiscott J, Lin R. Transcription factor IRF-2 exerts its oncogenic phenotype through the DNA binding/transcription repression domain. Oncogene. 11: 537-44. PMID 7630638  0.72
1995 Koromilas AE, Cantin C, Craig AW, Jagus R, Hiscott J, Sonenberg N. The interferon-inducible protein kinase PKR modulates the transcriptional activation of immunoglobulin kappa gene. The Journal of Biological Chemistry. 270: 25426-34. PMID 7592710 DOI: 10.1074/Jbc.270.43.25426  0.72
1995 Roulston A, Lin R, Beauparlant P, Wainberg MA, Hiscott J. Regulation of human immunodeficiency virus type 1 and cytokine gene expression in myeloid cells by NF-kappa B/Rel transcription factors. Microbiological Reviews. 59: 481-505. PMID 7565415  0.72
1994 Roulston A, Conti L, McKiel V, Wainberg MA, Hiscott J. Virus induction of NF-kappa B/Rel proteins and type I interferon gene expression in myelomonoblastic cells. Leukemia. 8: S170-4. PMID 8152286  0.36
1994 Garoufalis E, Kwan I, Lin R, Mustafa A, Pepin N, Roulston A, Lacoste J, Hiscott J. Viral induction of the human beta interferon promoter: modulation of transcription by NF-kappa B/rel proteins and interferon regulatory factors. Journal of Virology. 68: 4707-15. PMID 8035474 DOI: 10.1128/Jvi.68.8.4707-4715.1994  0.72
1994 Lin R, Mustafa A, Nguyen H, Gewert D, Hiscott J. Mutational analysis of interferon (IFN) regulatory factors 1 and 2. Effects on the induction of IFN-beta gene expression. The Journal of Biological Chemistry. 269: 17542-9. PMID 8021262  0.72
1994 Pepin N, Roulston A, Lacoste J, Lin R, Hiscott J. Subcellular redistribution of HTLV-1 Tax protein by NF-kappa B/Rel transcription factors. Virology. 204: 706-16. PMID 7941339 DOI: 10.1006/Viro.1994.1586  0.72
1994 Beauparlant P, Kwan I, Bitar R, Chou P, Koromilas AE, Sonenberg N, Hiscott J. Disruption of I kappa B alpha regulation by antisense RNA expression leads to malignant transformation. Oncogene. 9: 3189-97. PMID 7936641  0.72
1994 Kumar A, Haque J, Lacoste J, Hiscott J, Williams BR. Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B. Proceedings of the National Academy of Sciences of the United States of America. 91: 6288-92. PMID 7912826 DOI: 10.1073/Pnas.91.14.6288  0.72
1993 Gao Q, Gu Z, Hiscott J, Dionne G, Wainberg MA. Generation of drug-resistant variants of human immunodeficiency virus type 1 by in vitro passage in increasing concentrations of 2',3'-dideoxycytidine and 2',3'-dideoxy-3'-thiacytidine. Antimicrobial Agents and Chemotherapy. 37: 130-3. PMID 8381634 DOI: 10.1128/Aac.37.1.130  0.36
1993 Soudeyns H, Geleziunas R, Shyamala G, Hiscott J, Wainberg MA. Identification of a novel glucocorticoid response element within the genome of the human immunodeficiency virus type 1. Virology. 194: 758-68. PMID 7684876 DOI: 10.1006/Viro.1993.1317  0.36
1992 Roulston A, D'Addario M, Boulerice F, Caplan S, Wainberg MA, Hiscott J. Induction of monocytic differentiation and NF-kappa B-like activities by human immunodeficiency virus 1 infection of myelomonoblastic cells. The Journal of Experimental Medicine. 175: 751-63. PMID 1740663 DOI: 10.1084/Jem.175.3.751  0.36
1992 Boulerice F, Geleziunas R, Bour S, Li HL, D'Addario M, Roulston A, Hiscott J, Wainberg MA. Differential susceptibilities of U-937 cell clones to infection by human immunodeficiency virus type 1. Journal of Virology. 66: 1183-7. PMID 1731096 DOI: 10.1128/Jvi.66.2.1183-1187.1992  0.36
1992 Roberts NJ, Hiscott J, Signs DJ. The limited role of the human interferon system response to respiratory syncytial virus challenge: analysis and comparison to influenza virus challenge. Microbial Pathogenesis. 12: 409-14. PMID 1522795 DOI: 10.1016/0882-4010(92)90003-7  0.72
1992 D'Addario M, Wainberg MA, Hiscott J. Activation of cytokine genes in HIV-1 infected myelomonoblastic cells by phorbol ester and tumor necrosis factor. Journal of Immunology (Baltimore, Md. : 1950). 148: 1222-9. PMID 1371135  0.72
1991 Geleziunas R, Bour S, Boulerice F, Hiscott J, Wainberg MA. Diminution of CD4 surface protein but not CD4 messenger RNA levels in monocytic cells infected by HIV-1. Aids (London, England). 5: 29-33. PMID 2059359 DOI: 10.1097/00002030-199101000-00004  0.36
1991 Geleziunas R, McQuillan A, Malapetsa A, Hutchinson M, Kopriva D, Wainberg MA, Hiscott J, Bramson J, Panasci L. Increased DNA synthesis and repair-enzyme expression in lymphocytes from patients with chronic lymphocytic leukemia resistant to nitrogen mustards. Journal of the National Cancer Institute. 83: 557-64. PMID 2005641 DOI: 10.1093/Jnci/83.8.557  0.72
1990 D'Addario M, Roulston A, Wainberg MA, Hiscott J. Coordinate enhancement of cytokine gene expression in human immunodeficiency virus type 1-infected promonocytic cells. Journal of Virology. 64: 6080-9. PMID 2243388 DOI: 10.1128/Jvi.64.12.6080-6089.1990  0.72
1990 Lacoste J, D'Addario M, Roulston A, Wainberg MA, Hiscott J. Cell-specific differences in activation of NF-kappa B regulatory elements of human immunodeficiency virus and beta interferon promoters by tumor necrosis factor. Journal of Virology. 64: 4726-34. PMID 2204723 DOI: 10.1128/Jvi.64.10.4726-4734.1990  0.36
1990 Dubreuil M, Sportza L, D'Addario M, Lacoste J, Rooke R, Wainberg MA, Hiscott J. Inhibition of HIV-1 transmission by interferon and 3'-azido-3'-deoxythymidine during de novo infection of promonocytic cells. Virology. 179: 388-94. PMID 1699354 DOI: 10.1016/0042-6822(90)90306-C  0.36
1990 Tremblay M, Numazaki K, Li XG, Gornitsky M, Hiscott J, Wainberg MA. Resistance to infection by HIV-1 of peripheral blood mononuclear cells from HIV-1-infected patients is probably mediated by neutralizing antibodies. Journal of Immunology (Baltimore, Md. : 1950). 145: 2896-901. PMID 1698866  0.36
1984 Hiscott J, Cantell K, Weissmann C. Differential expression of human interferon genes. Nucleic Acids Research. 12: 3727-46. PMID 6427755 DOI: 10.1093/Nar/12.9.3727  0.72
1984 Hiscott J, Ryals J, Dierks P, Hofmann V, Weissmann C. The expression of human interferon alpha genes. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 307: 217-26. PMID 6151694  0.72
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