Ralph Lydic, Ph.D. - Publications

Affiliations: 
Anesthesiology University of Michigan, Ann Arbor, Ann Arbor, MI 

150 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Lu Y, Li YW, Wang L, Lydic R, Baghdoyan HA, Shi XY, Zhang H. Promoting sleep and circadian health may prevent postoperative delirium: A systematic review and meta-analysis of randomized clinical trials. Sleep Medicine Reviews. 48: 101207. PMID 31505369 DOI: 10.1016/j.smrv.2019.08.001  0.6
2018 McLain JM, Alami WH, Glovak ZT, Cooley CR, Burke SJ, Collier JJ, Baghdoyan HA, Karlstad MD, Lydic R. Sleep Fragmentation Delays Wound Healing in a Mouse Model of Type 2 Diabetes. Sleep. PMID 30107617 DOI: 10.1093/sleep/zsy156  0.6
2018 Bourdon AK, Spano GM, Marshall W, Bellesi M, Tononi G, Serra PA, Baghdoyan HA, Lydic R, Campagna SR, Cirelli C. Metabolomic analysis of mouse prefrontal cortex reveals upregulated analytes during wakefulness compared to sleep. Scientific Reports. 8: 11225. PMID 30046159 DOI: 10.1038/s41598-018-29511-6  0.6
2018 Lydic R, Baghdoyan HA, May AL. Neurochemistry of Anesthetic States. Methods in Enzymology. 603: 237-255. PMID 29673529 DOI: 10.1016/bs.mie.2018.01.024  0.6
2018 Angel C, Glovak ZT, Alami W, Mihalko S, Price J, Jiang Y, Baghdoyan HA, Lydic R. Buprenorphine Depresses Respiratory Variability in Obese Mice with Altered Leptin Signaling. Anesthesiology. PMID 29394163 DOI: 10.1097/ALN.0000000000002073  0.6
2017 Glovak Z, Mihalko S, Baghdoyan HA, Lydic R. Leptin Status Alters Buprenorphine-Induced Antinociception in Obese Mice with Dysfunctional Leptin Receptors. Neuroscience Letters. PMID 28893589 DOI: 10.1016/j.neulet.2017.09.012  0.6
2016 Zhang H, Wheat H, Wang P, Jiang S, Baghdoyan HA, Neubig RR, Shi XY, Lydic R. RGS proteins and gαi2 modulate sleep, wakefulness, and disruption of sleep/ wake states after isoflurane and sevoflurane anesthesia Sleep. 39: 393-404. DOI: 10.5665/sleep.5450  0.6
2015 Zhang H, Wheat H, Wang P, Jiang S, Baghdoyan HA, Neubig RR, Shi XY, Lydic R. RGS Proteins and Gαi2 Modulate Sleep, Wakefulness, and Disruption of Sleep/Wake States After Isoflurane and Sevoflurane Anesthesia. Sleep. PMID 26564126  0.6
2015 Garrity AG, Botta S, Lazar SB, Swor E, Vanini G, Baghdoyan HA, Lydic R. Dexmedetomidine-induced sedation does not mimic the neurobehavioral phenotypes of sleep in Sprague Dawley rat. Sleep. 38: 73-84. PMID 25325438 DOI: 10.5665/sleep.4328  0.6
2014 Watson SL, Watson CJ, Baghdoyan HA, Lydic R. Adenosine A₁ receptors in mouse pontine reticular formation modulate nociception only in the presence of systemic leptin. Neuroscience. 275: 531-9. PMID 24976513 DOI: 10.1016/j.neuroscience.2014.06.025  0.6
2014 Hambrecht-Wiedbusch VS, Mitchell MF, Firn KA, Baghdoyan HA, Lydic R. Benzodiazepine site agonists differentially alter acetylcholine release in rat amygdala. Anesthesia and Analgesia. 118: 1293-300. PMID 24842176 DOI: 10.1213/ANE.0000000000000201  0.6
2014 Filbey WA, Sanford DT, Baghdoyan HA, Koch LG, Britton SL, Lydic R. Eszopiclone and dexmedetomidine depress ventilation in obese rats with features of metabolic syndrome. Sleep. 37: 871-80. PMID 24790265 DOI: 10.5665/sleep.3650  0.6
2014 Vanini G, Nemanis K, Baghdoyan HA, Lydic R. GABAergic transmission in rat pontine reticular formation regulates the induction phase of anesthesia and modulates hyperalgesia caused by sleep deprivation. The European Journal of Neuroscience. 40: 2264-73. PMID 24674578 DOI: 10.1111/ejn.12571  0.6
2013 Janda A, Lydic R, Welch KB, Brummett CM. Thermal hyperalgesia after sciatic nerve block in rat is transient and clinically insignificant. Regional Anesthesia and Pain Medicine. 38: 151-4. PMID 23386052 DOI: 10.1097/AAP.0b013e3182813aae  0.6
2013 Gettys GC, Liu F, Kimlin E, Baghdoyan HA, Lydic R. Adenosine A(1) receptors in mouse pontine reticular formation depress breathing, increase anesthesia recovery time, and decrease acetylcholine release. Anesthesiology. 118: 327-36. PMID 23263018 DOI: 10.1097/ALN.0b013e31827d413e  0.6
2012 Watson CJ, Baghdoyan HA, Lydic R. Neuropharmacology of Sleep and Wakefulness: 2012 Update. Sleep Medicine Clinics. 7: 469-486. PMID 23162386 DOI: 10.1016/j.jsmc.2012.06.010  0.6
2012 Vanini G, Lydic R, Baghdoyan HA. GABA-to-ACh ratio in basal forebrain and cerebral cortex varies significantly during sleep. Sleep. 35: 1325-34. PMID 23024430 DOI: 10.5665/sleep.2106  0.6
2012 Wathen AB, West ES, Lydic R, Baghdoyan HA. Olanzapine causes a leptin-dependent increase in acetylcholine release in mouse prefrontal cortex. Sleep. 35: 315-23. PMID 22379237 DOI: 10.5665/sleep.1686  0.6
2012 Pal D, Walton ME, Lipinski WJ, Koch LG, Lydic R, Britton SL, Mashour GA. Determination of minimum alveolar concentration for isoflurane and sevoflurane in a rodent model of human metabolic syndrome. Anesthesia and Analgesia. 114: 297-302. PMID 22167771 DOI: 10.1213/ANE.0b013e31823ede22  0.6
2012 Baghdoyan HA, Lydic R. The Neurochemistry of Sleep and Wakefulness Basic Neurochemistry. 982-999. DOI: 10.1016/B978-0-12-374947-5.00057-2  0.6
2011 Gauthier EA, Guzick SE, Brummett CM, Baghdoyan HA, Lydic R. Buprenorphine disrupts sleep and decreases adenosine concentrations in sleep-regulating brain regions of Sprague Dawley rat. Anesthesiology. 115: 743-53. PMID 21857500 DOI: 10.1097/ALN.0b013e31822e9f85  0.6
2011 Lichtor JL, Lydic R. Volatile anesthesia does not satisfy rapid eye movement sleep debt. Anesthesiology. 115: 683-4. PMID 21829133 DOI: 10.1097/ALN.0b013e31822ddf30  0.6
2011 Watson CJ, Lydic R, Baghdoyan HA. Sleep duration varies as a function of glutamate and GABA in rat pontine reticular formation. Journal of Neurochemistry. 118: 571-80. PMID 21679185 DOI: 10.1111/j.1471-4159.2011.07350.x  0.6
2011 Brummett CM, Hong EK, Janda AM, Amodeo FS, Lydic R. Perineural dexmedetomidine added to ropivacaine for sciatic nerve block in rats prolongs the duration of analgesia by blocking the hyperpolarization-activated cation current. Anesthesiology. 115: 836-43. PMID 21666435 DOI: 10.1097/ALN.0b013e318221fcc9  0.6
2011 Chung F, Hillman D, Lydic R. Sleep medicine and anesthesia: a new horizon for anesthesiologists. Anesthesiology. 114: 1261-2. PMID 21422995 DOI: 10.1097/ALN.0b013e318216e858  0.6
2011 Vanini G, Wathen BL, Lydic R, Baghdoyan HA. Endogenous GABA levels in the pontine reticular formation are greater during wakefulness than during rapid eye movement sleep. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 2649-56. PMID 21325533 DOI: 10.1523/JNEUROSCI.5674-10.2011  0.6
2011 Chung F, Hillman D, Lydic R. In reply Anesthesiology. 115: 217. DOI: 10.1097/ALN.0b013e3182214b44  0.6
2011 Vanini G, Lydic R, Baghdoyan HA. GABAergic modulation of REM sleep Rapid Eye Movement Sleep: Regulation and Function. 206-213. DOI: 10.1017/CBO9780511921179.023  0.6
2011 Watson CJ, Baghdoyan HA, Lydic R. REM sleep regulation by cholinergic neurons: Highlights from 1999 to 2009 Rapid Eye Movement Sleep: Regulation and Function. 194-205. DOI: 10.1017/CBO9780511921179.022  0.6
2010 Watson CJ, Baghdoyan HA, Lydic R. Neuropharmacology of Sleep and Wakefulness. Sleep Medicine Clinics. 5: 513-528. PMID 21278831 DOI: 10.1016/j.jsmc.2010.08.003  0.6
2010 Brown EN, Lydic R, Schiff ND. General anesthesia, sleep, and coma. The New England Journal of Medicine. 363: 2638-50. PMID 21190458 DOI: 10.1056/NEJMra0808281  0.6
2010 Brevig HN, Watson CJ, Lydic R, Baghdoyan HA. Hypocretin and GABA interact in the pontine reticular formation to increase wakefulness. Sleep. 33: 1285-93. PMID 21061850  0.6
2010 Muncey AR, Saulles AR, Koch LG, Britton SL, Baghdoyan HA, Lydic R. Disrupted sleep and delayed recovery from chronic peripheral neuropathy are distinct phenotypes in a rat model of metabolic syndrome. Anesthesiology. 113: 1176-85. PMID 20938334 DOI: 10.1097/ALN.0b013e3181f56248  0.6
2010 Flint RR, Chang T, Lydic R, Baghdoyan HA. GABA(A) receptors in the pontine reticular formation of C57BL/6J mouse modulate neurochemical, electrographic, and behavioral phenotypes of wakefulness. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 12301-9. PMID 20844126 DOI: 10.1523/JNEUROSCI.1119-10.2010  0.6
2010 Brummett CM, Amodeo FS, Janda AM, Padda AK, Lydic R. Perineural dexmedetomidine provides an increased duration of analgesia to a thermal stimulus when compared with a systemic control in a rat sciatic nerve block. Regional Anesthesia and Pain Medicine. 35: 427-31. PMID 20814283 DOI: 10.1097/AAP.0b013e3181ef4cf0  0.6
2010 Hambrecht-Wiedbusch VS, Gauthier EA, Baghdoyan HA, Lydic R. Benzodiazepine receptor agonists cause drug-specific and state-specific alterations in EEG power and acetylcholine release in rat pontine reticular formation. Sleep. 33: 909-18. PMID 20614851  0.6
2010 Watson SL, Watson CJ, Baghdoyan HA, Lydic R. Thermal nociception is decreased by hypocretin-1 and an adenosine A1 receptor agonist microinjected into the pontine reticular formation of Sprague Dawley rat. The Journal of Pain : Official Journal of the American Pain Society. 11: 535-44. PMID 20015707 DOI: 10.1016/j.jpain.2009.09.010  0.6
2010 Vanini G, Baghdoyan HA, Lydic R. Relevance of sleep neurobiology for cognitive neuroscience and anesthesiology Consciousness, Awareness, and Anesthesia. 1-23. DOI: 10.1017/CBO9780511676291.002  0.6
2009 Nelson AM, Battersby AS, Baghdoyan HA, Lydic R. Opioid-induced decreases in rat brain adenosine levels are reversed by inhibiting adenosine deaminase. Anesthesiology. 111: 1327-33. PMID 19934879 DOI: 10.1097/ALN.0b013e3181bdf894  0.6
2009 Brummett CM, Padda AK, Amodeo FS, Welch KB, Lydic R. Perineural dexmedetomidine added to ropivacaine causes a dose-dependent increase in the duration of thermal antinociception in sciatic nerve block in rat. Anesthesiology. 111: 1111-9. PMID 19858875 DOI: 10.1097/ALN.0b013e3181bbcc26  0.6
2009 Icaza EE, Huang X, Fu Y, Neubig RR, Baghdoyan HA, Lydic R. Isoflurane-induced changes in righting response and breathing are modulated by RGS proteins. Anesthesia and Analgesia. 109: 1500-5. PMID 19843788 DOI: 10.1213/ANE.0b013e3181ba7815  0.6
2009 Wang W, Baghdoyan HA, Lydic R. Leptin replacement restores supraspinal cholinergic antinociception in leptin-deficient obese mice. The Journal of Pain : Official Journal of the American Pain Society. 10: 836-43. PMID 19380255 DOI: 10.1016/j.jpain.2009.02.003  0.6
2009 Van Dort CJ, Baghdoyan HA, Lydic R. Adenosine A(1) and A(2A) receptors in mouse prefrontal cortex modulate acetylcholine release and behavioral arousal. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 871-81. PMID 19158311 DOI: 10.1523/JNEUROSCI.4111-08.2009  0.6
2009 Hambrecht VS, Vlisides PE, Row BW, Gozal D, Baghdoyan HA, Lydic R. G proteins in rat prefrontal cortex (PFC) are differentially activated as a function of oxygen status and PFC region. Journal of Chemical Neuroanatomy. 37: 112-7. PMID 19118621 DOI: 10.1016/j.jchemneu.2008.12.002  0.6
2008 Zhu Z, Bowman HR, Baghdoyan HA, Lydic R. Morphine increases acetylcholine release in the trigeminal nuclear complex. Sleep. 31: 1629-37. PMID 19090318  0.6
2008 Vanini G, Watson CJ, Lydic R, Baghdoyan HA. Gamma-aminobutyric acid-mediated neurotransmission in the pontine reticular formation modulates hypnosis, immobility, and breathing during isoflurane anesthesia. Anesthesiology. 109: 978-88. PMID 19034094 DOI: 10.1097/ALN.0b013e31818e3b1b  0.6
2008 Lydic R. The motor atonia of REM sleep: a critical topics forum. Introduction. Sleep. 31: 1471-2. PMID 19014063  0.6
2008 Brummett CM, Norat MA, Palmisano JM, Lydic R. Perineural administration of dexmedetomidine in combination with bupivacaine enhances sensory and motor blockade in sciatic nerve block without inducing neurotoxicity in rat. Anesthesiology. 109: 502-11. PMID 18719449 DOI: 10.1097/ALN.0b013e318182c26b  0.6
2008 Geisser ME, Wang W, Smuck M, Koch LG, Britton SL, Lydic R. Nociception before and after exercise in rats bred for high and low aerobic capacity. Neuroscience Letters. 443: 37-40. PMID 18657596 DOI: 10.1016/j.neulet.2008.07.040  0.6
2008 Van Dort CJ, Baghdoyan HA, Lydic R. Neurochemical modulators of sleep and anesthetic states. International Anesthesiology Clinics. 46: 75-104. PMID 18617819 DOI: 10.1097/AIA.0b013e318181a8ca  0.6
2008 Watson CJ, Soto-Calderon H, Lydic R, Baghdoyan HA. Pontine reticular formation (PnO) administration of hypocretin-1 increases PnO GABA levels and wakefulness. Sleep. 31: 453-64. PMID 18457232  0.6
2008 Lydic R, Baghdoyan HA. Acetylcholine modulates sleep and wakefulness: A synaptic perspective Neurochemistry of Sleep and Wakefulness. 109-143. DOI: 10.1017/CBO9780511541674.006  0.6
2007 Hambrecht VS, Vlisides PE, Row BW, Gozal D, Baghdoyan HA, Lydic R. Hypoxia modulates cholinergic but not opioid activation of G proteins in rat hippocampus. Hippocampus. 17: 934-42. PMID 17598161 DOI: 10.1002/hipo.20312  0.6
2007 Skulsky EM, Osman NI, Baghdoyan HA, Lydic R. Microdialysis delivery of morphine to the hypoglossal nucleus of Wistar rat increases hypoglossal acetylcholine release. Sleep. 30: 566-73. PMID 17552371  0.6
2007 Watson CJ, Lydic R, Baghdoyan HA. Sleep and GABA levels in the oral part of rat pontine reticular formation are decreased by local and systemic administration of morphine. Neuroscience. 144: 375-86. PMID 17055662 DOI: 10.1016/j.neuroscience.2006.09.007  0.6
2006 Coleman CG, Baghdoyan HA, Lydic R. Dialysis delivery of an adenosine A2A agonist into the pontine reticular formation of C57BL/6J mouse increases pontine acetylcholine release and sleep. Journal of Neurochemistry. 96: 1750-9. PMID 16539690 DOI: 10.1111/j.1471-4159.2006.03700.x  0.6
2006 Lydic R. Sleep disruption is related to allelic variation in the ob gene. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 290: R892-3. PMID 16537820 DOI: 10.1152/ajpregu.00845.2005  0.6
2006 Lydic R, Garza-Grande R, Struthers R, Baghdoyan HA. Nitric oxide in B6 mouse and nitric oxide-sensitive soluble guanylate cyclase in cat modulate acetylcholine release in pontine reticular formation. Journal of Applied Physiology (Bethesda, Md. : 1985). 100: 1666-73. PMID 16424074 DOI: 10.1152/japplphysiol.00962.2005  0.6
2006 Bernard R, Lydic R, Baghdoyan HA. Hypocretin (orexin) receptor subtypes differentially enhance acetylcholine release and activate g protein subtypes in rat pontine reticular formation. The Journal of Pharmacology and Experimental Therapeutics. 317: 163-71. PMID 16352704 DOI: 10.1124/jpet.105.097071  0.6
2006 Lydic R, Baghdoyan HA. Sleep and anesthesia Foundations of Anesthesia. 361-371. DOI: 10.1016/B978-0-323-03707-5.50036-X  0.6
2005 Lydic R, Baghdoyan HA. Sleep, anesthesiology, and the neurobiology of arousal state control. Anesthesiology. 103: 1268-95. PMID 16306742  0.6
2005 Osman NI, Baghdoyan HA, Lydic R. Morphine inhibits acetylcholine release in rat prefrontal cortex when delivered systemically or by microdialysis to basal forebrain. Anesthesiology. 103: 779-87. PMID 16192770 DOI: 10.1097/00000542-200510000-00016  0.6
2005 Douglas CL, Bowman GN, Baghdoyan HA, Lydic R. C57BL/6J and B6.V-LEPOB mice differ in the cholinergic modulation of sleep and breathing. Journal of Applied Physiology (Bethesda, Md. : 1985). 98: 918-29. PMID 15475596 DOI: 10.1152/japplphysiol.00900.2004  0.6
2005 Lydic R, Baghdoyan HA. Relevance of Anesthesiology for Sleep Medicine Sleep: a Comprehensive Handbook. 927-932. DOI: 10.1002/0471751723.ch121  0.6
2004 Douglas CL, Demarco GJ, Baghdoyan HA, Lydic R. Pontine and basal forebrain cholinergic interaction: implications for sleep and breathing. Respiratory Physiology & Neurobiology. 143: 251-62. PMID 15519559 DOI: 10.1016/j.resp.2004.02.011  0.6
2004 Coleman CG, Lydic R, Baghdoyan HA. Acetylcholine release in the pontine reticular formation of C57BL/6J mouse is modulated by non-M1 muscarinic receptors. Neuroscience. 126: 831-8. PMID 15207318 DOI: 10.1016/j.neuroscience.2004.04.045  0.6
2004 Coleman CG, Lydic R, Baghdoyan HA. M2 muscarinic receptors in pontine reticular formation of C57BL/6J mouse contribute to rapid eye movement sleep generation. Neuroscience. 126: 821-30. PMID 15207317 DOI: 10.1016/j.neuroscience.2004.04.029  0.6
2004 Demarco GJ, Baghdoyan HA, Lydic R. Carbachol in the pontine reticular formation of C57BL/6J mouse decreases acetylcholine release in prefrontal cortex. Neuroscience. 123: 17-29. PMID 14667438 DOI: 10.1016/j.neuroscience.2003.08.045  0.6
2003 Bernard R, Lydic R, Baghdoyan HA. Hypocretin-1 causes G protein activation and increases ACh release in rat pons. The European Journal of Neuroscience. 18: 1775-85. PMID 14622212 DOI: 10.1046/j.1460-9568.2003.02905.x  0.6
2003 Tanase D, Baghdoyan HA, Lydic R. Dialysis delivery of an adenosine A1 receptor agonist to the pontine reticular formation decreases acetylcholine release and increases anesthesia recovery time. Anesthesiology. 98: 912-20. PMID 12657853 DOI: 10.1097/00000542-200304000-00018  0.6
2003 Demarco GJ, Baghdoyan HA, Lydic R. Differential cholinergic activation of G proteins in rat and mouse brainstem: relevance for sleep and nociception. The Journal of Comparative Neurology. 457: 175-84. PMID 12541317 DOI: 10.1002/cne.10548  0.6
2002 Lydic R, Douglas CL, Baghdoyan HA. Microinjection of neostigmine into the pontine reticular formation of C57BL/6J mouse enhances rapid eye movement sleep and depresses breathing. Sleep. 25: 835-41. PMID 12489888  0.6
2002 Douglas CL, Baghdoyan HA, Lydic R. Postsynaptic muscarinic M1 receptors activate prefrontal cortical EEG of C57BL/6J mouse. Journal of Neurophysiology. 88: 3003-9. PMID 12466425 DOI: 10.1152/jn.00318.2002  0.6
2002 Tanase D, Baghdoyan HA, Lydic R. Microinjection of an adenosine A1 agonist into the medial pontine reticular formation increases tail flick latency to thermal stimulation. Anesthesiology. 97: 1597-601. PMID 12459690 DOI: 10.1097/00000542-200212000-00036  0.6
2002 Lydic R. Fact and fantasy about sleep and anesthesiology. Anesthesiology. 97: 1050-1. PMID 12411785 DOI: 10.1097/00000542-200211000-00004  0.6
2002 Lydic R, Baghdoyan HA. Ketamine and MK-801 decrease acetylcholine release in the pontine reticular formation, slow breathing, and disrupt sleep. Sleep. 25: 617-22. PMID 12224840  0.6
2002 Orem J, Lydic R. Upper airway function during sleep and wakefulness: experimental studies on normal and anesthetized cats. 1978 [classical article]. Sleep. 25: 49-68. PMID 12150314  0.6
2002 Vazquez J, Lydic R, Baghdoyan HA. The nitric oxide synthase inhibitor NG-Nitro-L-arginine increases basal forebrain acetylcholine release during sleep and wakefulness. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 5597-605. PMID 12097511  0.6
2002 Douglas CL, Baghdoyan HA, Lydic R. Prefrontal cortex acetylcholine release, EEG slow waves, and spindles are modulated by M2 autoreceptors in C57BL/6J mouse. Journal of Neurophysiology. 87: 2817-22. PMID 12037184  0.6
2002 Bernard R, Lydic R, Baghdoyan HA. Hypocretin-1 activates G proteins in arousal-related brainstem nuclei of rat. Neuroreport. 13: 447-50. PMID 11930158  0.6
2001 Douglas CL, Baghdoyan HA, Lydic R. M2 muscarinic autoreceptors modulate acetylcholine release in prefrontal cortex of C57BL/6J mouse. The Journal of Pharmacology and Experimental Therapeutics. 299: 960-6. PMID 11714883  0.6
2001 Tanase D, Martin WA, Baghdoyan HA, Lydic R. G protein activation in rat ponto-mesencephalic nuclei is enhanced by combined treatment with a mu opioid and an adenosine A1 receptor agonist. Sleep. 24: 52-62. PMID 11204054  0.6
2001 Lydic R. Pain: a bridge linking anesthesiology and sleep research. Sleep. 24: 10-2. PMID 11204045  0.6
2000 Lydic R, Baghdoyan HA. Koch's postulates confirm cholinergic modulation of REM sleep Behavioral and Brain Sciences. 23: 966.  0.6
1999 Baghdoyan HA, Lydic R. M2 muscarinic receptor subtype in the feline medial pontine reticular formation modulates the amount of rapid eye movement sleep. Sleep. 22: 835-47. PMID 10566902  0.6
1999 Mortazavi S, Thompson J, Baghdoyan HA, Lydic R. Fentanyl and morphine, but not remifentanil, inhibit acetylcholine release in pontine regions modulating arousal. Anesthesiology. 90: 1070-7. PMID 10201679 DOI: 10.1097/00000542-199904000-00021  0.6
1998 Kshatri AM, Baghdoyan HA, Lydic R. Cholinomimetics, but not morphine, increase antinociceptive behavior from pontine reticular regions regulating rapid-eye-movement sleep. Sleep. 21: 677-85. PMID 11286343  0.6
1998 Capece ML, Baghdoyan HA, Lydic R. Opioids activate G proteins in REM sleep-related brain stem nuclei of rat. Neuroreport. 9: 3025-8. PMID 9804309  0.6
1998 Baghdoyan HA, Lydic R, Fleegal MA. M2 muscarinic autoreceptors modulate acetylcholine release in the medial pontine reticular formation. The Journal of Pharmacology and Experimental Therapeutics. 286: 1446-52. PMID 9732410  0.6
1998 Capece ML, Baghdoyan HA, Lydic R. Carbachol stimulates [35S]guanylyl 5'-(gamma-thio)-triphosphate binding in rapid eye movement sleep-related brainstem nuclei of rat. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 3779-85. PMID 9570808  0.6
1997 Capece ML, Lydic R. cAMP and protein kinase A modulate cholinergic rapid eye movement sleep generation. The American Journal of Physiology. 273: R1430-40. PMID 9362309  0.6
1997 Capece ML, Efange SM, Lydic R. Vesicular acetylcholine transport inhibitor suppresses REM sleep. Neuroreport. 8: 481-4. PMID 9080433  0.6
1997 Leonard TO, Lydic R. Pontine nitric oxide modulates acetylcholine release, rapid eye movement sleep generation, and respiratory rate. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 774-85. PMID 8987799  0.6
1996 Lydic R. Reticular modulation of breathing during sleep and anesthesia. Current Opinion in Pulmonary Medicine. 2: 474-81. PMID 9363188  0.6
1996 Roth MT, Fleegal MA, Lydic R, Baghdoyan HA. Pontine acetylcholine release is regulated by muscarinic autoreceptors. Neuroreport. 7: 3069-72. PMID 9116242  0.6
1996 Keifer JC, Baghdoyan HA, Lydic R. Pontine cholinergic mechanisms modulate the cortical electroencephalographic spindles of halothane anesthesia. Anesthesiology. 84: 945-54. PMID 8638850 DOI: 10.1097/00000542-199604000-00023  0.6
1995 Fitzgerald RS, Shirahata M, Ide T, Lydic R. The cholinergic hypothesis revisited--an unfinished story. Biological Signals. 4: 298-303. PMID 8704831  0.6
1995 Lee LH, Friedman DB, Lydic R. Respiratory nuclei share synaptic connectivity with pontine reticular regions regulating REM sleep. The American Journal of Physiology. 268: L251-62. PMID 7864146  0.6
1995 Cronin A, Keifer JC, Baghdoyan HA, Lydic R. Opioid inhibition of rapid eye movement sleep by a specific mu receptor agonist. British Journal of Anaesthesia. 74: 188-92. PMID 7696070 DOI: 10.1093/bja/74.2.188  0.6
1995 Shuman SL, Capece ML, Baghdoyan HA, Lydic R. Pertussis toxin-sensitive G proteins mediate carbachol-induced REM sleep and respiratory depression. The American Journal of Physiology. 269: R308-17. PMID 7653652  0.6
1995 Mallios VJ, Lydic R, Baghdoyan HA. Muscarinic receptor subtypes are differentially distributed across brain stem respiratory nuclei. The American Journal of Physiology. 268: L941-9. PMID 7611435  0.6
1995 Leonard TO, Lydic R. Nitric oxide synthase inhibition decreases pontine acetylcholine release. Neuroreport. 6: 1525-9. PMID 7579140  0.6
1995 Fitzgerald RS, Shirahata M, Ide T, Lydic R. The cholinergic hypothesis revisited – an unfinished story Neurosignals. 4: 298-303. DOI: 10.1159/000109456  0.6
1994 Gilbert KA, Lydic R. Pontine cholinergic reticular mechanisms cause state-dependent changes in the discharge of parabrachial neurons. The American Journal of Physiology. 266: R136-50. PMID 8304534  0.6
1994 Lydic R, Biebuyck JF. Sleep neurobiology: relevance for mechanistic studies of anaesthesia. British Journal of Anaesthesia. 72: 506-8. PMID 8198898 DOI: 10.1093/bja/72.5.506  0.6
1994 Keifer JC, Baghdoyan HA, Becker L, Lydic R. Halothane decreases pontine acetylcholine release and increases EEG spindles. Neuroreport. 5: 577-80. PMID 8025247  0.6
1993 Gilbert KA, Lydic R. Muscarinic cholinoceptive reticular mechanisms and parabrachial neuron discharge: a novel experimental approach. Neuroreport. 4: 271-4. PMID 8477050  0.6
1993 Lydic R, Baghdoyan HA. Pedunculopontine stimulation alters respiration and increases ACh release in the pontine reticular formation. The American Journal of Physiology. 264: R544-54. PMID 8457006  0.6
1993 Lydic R, Keifer JC, Baghdoyan HA, Becker L. Microdialysis of the pontine reticular formation reveals inhibition of acetylcholine release by morphine. Anesthesiology. 79: 1003-12. PMID 8238979  0.6
1993 Fay R, Gilbert KA, Lydic R. Pontomedullary neurons transsynaptically labeled by laryngeal pseudorabies virus. Neuroreport. 5: 141-4. PMID 7509204  0.6
1992 Keifer JC, Baghdoyan HA, Lydic R. Sleep disruption and increased apneas after pontine microinjection of morphine. Anesthesiology. 77: 973-82. PMID 1443752 DOI: 10.1097/00000542-199211000-00021  0.6
1991 Lydic R, Baghdoyan HA, Hibbard L, Bonyak EV, DeJoseph MR, Hawkins RA. Regional brain glucose metabolism is altered during rapid eye movement sleep in the cat: a preliminary study. The Journal of Comparative Neurology. 304: 517-29. PMID 2013648 DOI: 10.1002/cne.903040402  0.6
1991 Lydic R, Baghdoyan HA, Lorinc Z. Microdialysis of cat pons reveals enhanced acetylcholine release during state-dependent respiratory depression. The American Journal of Physiology. 261: R766-70. PMID 1887963  0.6
1991 Lorinc Z, Derr J, Snider M, Lydic R. Defining origin of positive slope in hypercapnic ventilatory response curve. The American Journal of Physiology. 261: R747-51. PMID 1679610  0.6
1991 Lydic R, Baghdoyan HA, Wertz R, White DP. Cholinergic reticular mechanisms influence state-dependent ventilatory response to hypercapnia. The American Journal of Physiology. 261: R738-46. PMID 1679609  0.6
1990 Gilbert KA, Lydic R. Parabrachial neuron discharge in the cat is altered during the carbachol-induced REM sleep-like state (DCarb). Neuroscience Letters. 120: 241-4. PMID 2293110 DOI: 10.1016/0304-3940(90)90049-F  0.6
1989 Lydic R, Baghdoyan HA, Zwillich CW. State-dependent hypotonia in posterior cricoarytenoid muscles of the larynx caused by cholinoceptive reticular mechanisms. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 3: 1625-31. PMID 2920876  0.6
1989 Lydic R, Baghdoyan HA. Cholinoceptive pontine reticular mechanisms cause state-dependent respiratory changes in the cat. Neuroscience Letters. 102: 211-6. PMID 2812500 DOI: 10.1016/0304-3940(89)90080-3  0.6
1989 Lydic R. Central pattern-generating neurons and the search for general principles. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 3: 2457-68. PMID 2680703  0.6
1989 Baghdoyan HA, Lydic R, Callaway CW, Hobson JA. The carbachol-induced enhancement of desynchronized sleep signs is dose dependent and antagonized by centrally administered atropine. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 2: 67-79. PMID 2572234  0.6
1987 Baghdoyan HA, Lydic R, Callaway CW, Hobson JA. Increased ponto-geniculo-occipital (PGO) wave frequency following central administration of neostigmine. Neuroscience Letters. 82: 278-84. PMID 3696500 DOI: 10.1016/0304-3940(87)90269-2  0.6
1987 Schwartz WJ, Lydic R, Moore-Ede MC. In vivo metabolic activity of the suprachiasmatic nuclei: non-uniform intranuclear distribution of 14C-labeled deoxyglucose uptake. Brain Research. 424: 249-57. PMID 3676827 DOI: 10.1016/0006-8993(87)91468-5  0.6
1987 Lydic R, McCarley RW, Hobson JA. Serotonin neurons and sleep. II. Time course of dorsal raphe discharge, PGO waves, and behavioral states. Archives Italiennes De Biologie. 126: 1-28. PMID 3449005  0.6
1987 Lydic R, McCarley RW, Hobson JA. Serotonin neurons and sleep. I. Long term recordings of dorsal raphe discharge frequency and PGO waves. Archives Italiennes De Biologie. 125: 317-43. PMID 3439827  0.6
1987 Callaway CW, Lydic R, Baghdoyan HA, Hobson JA. Pontogeniculooccipital waves: spontaneous visual system activity during rapid eye movement sleep. Cellular and Molecular Neurobiology. 7: 105-49. PMID 3308096 DOI: 10.1007/BF00711551  0.6
1987 Lydic R. State-dependent aspects of regulatory physiology. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 1: 6-15. PMID 3301498  0.6
1985 Gander PH, Lydic R, Albers HE, Moore-Ede MC. Forced internal desynchronization between circadian temperature and activity rhythms in squirrel monkeys. The American Journal of Physiology. 248: R567-72. PMID 3993815  0.6
1984 Albers HE, Lydic R, Moore-Ede MC. Role of the suprachiasmatic nuclei in the circadian timing system of the squirrel monkey. II. Light-dark cycle entrainment. Brain Research. 300: 285-93. PMID 6733474 DOI: 10.1016/0006-8993(84)90838-2  0.6
1984 Albers HE, Lydic R, Gander PH, Moore-Ede MC. Role of the suprachiasmatic nuclei in the circadian timing system of the squirrel monkey. I. The generation of rhythmicity. Brain Research. 300: 275-84. PMID 6733473 DOI: 10.1016/0006-8993(84)90837-0  0.6
1984 Stopa EG, King JC, Lydic R, Schoene WC. Human brain contains vasopressin and vasoactive intestinal polypeptide neuronal subpopulations in the suprachiasmatic region. Brain Research. 297: 159-63. PMID 6372941 DOI: 10.1016/0006-8993(84)90553-5  0.6
1984 Lydic R, McCarley RW, Hobson JA. Forced activity alters sleep cycle periodicity and dorsal raphe discharge rhythm. The American Journal of Physiology. 247: R135-45. PMID 6331207  0.6
1983 Lydic R, McCarley RW, Hobson JA. Enhancement of dorsal raphe discharge by medial pontine reticular formation stimulation depends on behavioral state. Neuroscience Letters. 38: 35-40. PMID 6888805 DOI: 10.1016/0304-3940(83)90106-4  0.6
1983 Fuller CA, Lydic R, Sulzman FM, Albers HE, Tepper B, Moore-Ede MC. Auditory entrainment of primate drinking rhythms following partial suprachiasmatic nuclei lesions. Physiology & Behavior. 31: 573-6. PMID 6657774 DOI: 10.1016/0031-9384(83)90085-9  0.6
1983 Lydic R, McCarley RW, Hobson JA. The time-course of dorsal raphe discharge, PGO waves, and muscle tone averaged across multiple sleep cycles. Brain Research. 274: 365-70. PMID 6626966 DOI: 10.1016/0006-8993(83)90720-5  0.6
1982 Albers HE, Lydic R, Moore-Ede MC. Entrainment and masking of circadian drinking rhythms in primates: influence of light intensity. Physiology & Behavior. 28: 205-11. PMID 7079331 DOI: 10.1016/0031-9384(82)90063-4  0.6
1982 Lydic R, Albers HE, Tepper B, Moore-Ede MC. Three-dimensional structure of the mammalian suprachiasmatic nuclei: a comparative study of five species. The Journal of Comparative Neurology. 204: 225-37. PMID 7056891 DOI: 10.1002/cne.902040303  0.6
1981 Albers HE, Lydic R, Gander PH, Moore-Ede MC. Gradual decay of circadian drinking organization following lesions of the suprachiasmatic nuclei in primates. Neuroscience Letters. 27: 119-24. PMID 7322446 DOI: 10.1016/0304-3940(81)90254-8  0.6
1981 Fuller CA, Lydic R, Sulzman FM, Albers HE, Tepper B, Moore-Ede MC. Circadian rhythm of body temperature persists after suprachiasmatic lesions in the squirrel monkey. The American Journal of Physiology. 241: R385-91. PMID 7304784  0.6
1980 Lydic R, Moore-Ede MC. Three dimensional structure of the suprachiasmatic nuclei in the diurnal squirrel monkey (Saimiri sciureus). Neuroscience Letters. 17: 295-9. PMID 7052475 DOI: 10.1016/0304-3940(80)90039-7  0.6
1980 Lydic R, Schoene WC, Czeisler CA, Moore-Ede MC. Suprachiasmatic region of the human hypothalamus: homolog to the primate circadian pacemaker? Sleep. 2: 355-61. PMID 6773133  0.6
1979 Orem J, Lydic R, Norris P. Experimental control of the diaphragm and laryngeal abductor muscles by brain stem arousal systems. Respiration Physiology. 38: 203-21. PMID 504830 DOI: 10.1016/0034-5687(79)90037-9  0.6
1979 Lydic R, Orem J. Respiratory neurons of the pneumotaxic center during sleep and wakefulness. Neuroscience Letters. 15: 187-92. PMID 231237 DOI: 10.1016/0304-3940(79)96111-1  0.6
1978 Anderson DE, Lydic R. A simulation program examining the use of ratios as raw variables in analyses of variance. Computer Programs in Biomedicine. 8: 87-90. PMID 668310 DOI: 10.1016/0010-468X(78)90042-9  0.6
1978 Orem J, Lydic R. Upper airway function during sleep and wakefulness: experimental studies on normal and anesthetized cats. Sleep. 1: 49-68. PMID 227023  0.6
1978 Orem J, Norris P, Lydic R. Laryngeal abductor activity during sleep. Chest. 73: 300-1. PMID 202438  0.6
1977 Lydic RB, Britton SL, Davies DG, Lutherer LO, Anderson D. An interactive program on the PDP-11 for computing organ blood flow from data obtained using the radioactive microsphere technique. Computer Programs in Biomedicine. 7: 287-92. PMID 340123 DOI: 10.1016/0010-468X(77)90044-7  0.6
1977 Anderson D, Lydic R. Ratio data and the quantification of drug effects Biobehavioral Reviews. 1: 55-57. DOI: 10.1016/0147-7552(77)90041-9  0.6
1977 Anderson DE, Lydic R. On the effect of using ratios in the analysis of variance Biobehavioral Reviews. 1: 225-229. DOI: 10.1016/0147-7552(77)90024-9  0.6
1976 Carlson RH, Lydic R. The effects of ethanol upon threshold and response rate for self-stimulation. Psychopharmacology. 50: 61-4. PMID 827763 DOI: 10.1007/BF00634156  0.6
1974 Lydic R, Anson J. A modified shock delivery system for quail Journal of the Experimental Analysis of Behavior. 22: 441-443.  0.6
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