Kay M. Tye, Ph.D. - Publications

Affiliations: 
Massachusetts Institute of Technology, Cambridge, MA, United States 
Area:
Amygdala, Reward, Anxiety, Plasticity

50 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Weele CMV, Siciliano CA, Tye KM. Dopamine tunes prefrontal outputs to orchestrate aversive processing. Brain Research. PMID 30513287 DOI: 10.1016/j.brainres.2018.11.044  1
2018 Siciliano CA, Tye KM. Leveraging calcium imaging to illuminate circuit dysfunction in addiction. Alcohol (Fayetteville, N.Y.). PMID 30470589 DOI: 10.1016/j.alcohol.2018.05.013  1
2018 Vander Weele CM, Siciliano CA, Matthews GA, Namburi P, Izadmehr EM, Espinel IC, Nieh EH, Schut EHS, Padilla-Coreano N, Burgos-Robles A, Chang CJ, Kimchi EY, Beyeler A, Wichmann R, Wildes CP, ... Tye KM, et al. Dopamine enhances signal-to-noise ratio in cortical-brainstem encoding of aversive stimuli. Nature. PMID 30405240 DOI: 10.1038/s41586-018-0682-1  1
2018 Siciliano CA, Mills F, Tye KM. Double threat in striatal dopamine signaling. Nature Neuroscience. 21: 1296-1297. PMID 30258236 DOI: 10.1038/s41593-018-0243-9  1
2018 Allsop SA, Wichmann R, Mills F, Burgos-Robles A, Chang CJ, Felix-Ortiz AC, Vienne A, Beyeler A, Izadmehr EM, Glober G, Cum MI, Stergiadou J, Anandalingam KK, Farris K, Namburi P, ... ... Tye KM, et al. Corticoamygdala Transfer of Socially Derived Information Gates Observational Learning. Cell. PMID 29731170 DOI: 10.1016/j.cell.2018.04.004  0.96
2018 Chatterjee S, Sullivan HA, MacLennan BJ, Xu R, Hou Y, Lavin TK, Lea NE, Michalski JE, Babcock KR, Dietrich S, Matthews GA, Beyeler A, Calhoon GG, Glober G, Whitesell JD, ... ... Tye KM, et al. Nontoxic, double-deletion-mutant rabies viral vectors for retrograde targeting of projection neurons. Nature Neuroscience. PMID 29507411 DOI: 10.1038/s41593-018-0091-7  1
2018 Beyeler A, Chang CJ, Silvestre M, Lévêque C, Namburi P, Wildes CP, Tye KM. Organization of Valence-Encoding and Projection-Defined Neurons in the Basolateral Amygdala. Cell Reports. 22: 905-918. PMID 29386133 DOI: 10.1016/j.celrep.2017.12.097  0.96
2017 Wang W, Wildes CP, Pattarabanjird T, Sanchez MI, Glober GF, Matthews GA, Tye KM, Ting AY. A light- and calcium-gated transcription factor for imaging and manipulating activated neurons. Nature Biotechnology. PMID 28650461 DOI: 10.1038/nbt.3909  0.96
2017 Burgos-Robles A, Kimchi EY, Izadmehr EM, Porzenheim MJ, Ramos-Guasp WA, Nieh EH, Felix-Ortiz AC, Namburi P, Leppla CA, Presbrey KN, Anandalingam KK, Pagan-Rivera PA, Anahtar M, Beyeler A, Tye KM. Amygdala inputs to prefrontal cortex guide behavior amid conflicting cues of reward and punishment. Nature Neuroscience. PMID 28436980 DOI: 10.1038/nn.4553  0.96
2016 Matthews GA, Tye KM. A New Handle for a Hot Topic: Genetic Markers for Warm-Sensing. Cell. 167: 43-4. PMID 27662082 DOI: 10.1016/j.cell.2016.09.016  0.96
2016 Nieh EH, Vander Weele CM, Matthews GA, Presbrey KN, Wichmann R, Leppla CA, Izadmehr EM, Tye KM. Inhibitory Input from the Lateral Hypothalamus to the Ventral Tegmental Area Disinhibits Dopamine Neurons and Promotes Behavioral Activation. Neuron. PMID 27238864 DOI: 10.1016/j.neuron.2016.04.035  1
2016 Beyeler A, Namburi P, Glober GF, Simonnet C, Calhoon GG, Conyers GF, Luck R, Wildes CP, Tye KM. Divergent Routing of Positive and Negative Information from the Amygdala during Memory Retrieval. Neuron. PMID 27041499 DOI: 10.1016/j.neuron.2016.03.004  1
2016 Matthews GA, Nieh EH, Vander Weele CM, Halbert SA, Pradhan RV, Yosafat AS, Glober GF, Izadmehr EM, Thomas RE, Lacy GD, Wildes CP, Ungless MA, Tye KM. Dorsal Raphe Dopamine Neurons Represent the Experience of Social Isolation. Cell. 164: 617-31. PMID 26871628 DOI: 10.1016/j.cell.2015.12.040  1
2015 Namburi P, Al-Hasani R, Calhoon GG, Bruchas MR, Tye KM. Architectural Representation of Valence in the Limbic System. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 26647973 DOI: 10.1038/npp.2015.358  0.68
2015 Calhoon GG, Tye KM. Resolving the neural circuits of anxiety. Nature Neuroscience. 18: 1394-404. PMID 26404714 DOI: 10.1038/nn.4101  1
2015 Adamantidis A, Arber S, Bains JS, Bamberg E, Bonci A, Buzsáki G, Cardin JA, Costa RM, Dan Y, Goda Y, Graybiel AM, Häusser M, Hegemann P, Huguenard JR, Insel TR, ... ... Tye KM, et al. Optogenetics: 10 years after ChR2 in neurons--views from the community. Nature Neuroscience. 18: 1202-12. PMID 26308981 DOI: 10.1038/nn.4106  1
2015 Felix-Ortiz AC, Burgos-Robles A, Bhagat ND, Leppla CA, Tye KM. Bidirectional modulation of anxiety-related and social behaviors by amygdala projections to the medial prefrontal cortex. Neuroscience. PMID 26204817 DOI: 10.1016/j.neuroscience.2015.07.041  0.84
2015 Namburi P, Beyeler A, Yorozu S, Calhoon GG, Halbert SA, Wichmann R, Holden SS, Mertens KL, Anahtar M, Felix-Ortiz AC, Wickersham IR, Gray JM, Tye KM. A circuit mechanism for differentiating positive and negative associations. Nature. 520: 675-8. PMID 25925480 DOI: 10.1038/nature14366  1
2015 Sidor MM, Spencer SM, Dzirasa K, Parekh PK, Tye KM, Warden MR, Arey RN, Enwright JF, Jacobsen JP, Kumar S, Remillard EM, Caron MG, Deisseroth K, McClung CA. Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice. Molecular Psychiatry. PMID 25687774 DOI: 10.1038/mp.2015.8  1
2015 Sidor MM, Davidson TJ, Tye KM, Warden MR, Diesseroth K, McClung CA. In vivo optogenetic stimulation of the rodent central nervous system. Journal of Visualized Experiments : Jove. 51483. PMID 25651158 DOI: 10.3791/51483  1
2015 Nieh EH, Matthews GA, Allsop SA, Presbrey KN, Leppla CA, Wichmann R, Neve R, Wildes CP, Tye KM. Decoding neural circuits that control compulsive sucrose seeking. Cell. 160: 528-41. PMID 25635460 DOI: 10.1016/j.cell.2015.01.003  1
2015 Janak PH, Tye KM. From circuits to behaviour in the amygdala. Nature. 517: 284-92. PMID 25592533 DOI: 10.1038/nature14188  1
2015 Sidor MM, Spencer SM, Dzirasa K, Parekh PK, Tye KM, Warden MR, Arey RN, Enwright JF, Jacobsen JP, Kumar S, Remillard EM, Caron MG, Deisseroth K, McClung CA. Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice. Molecular Psychiatry. 5. PMID 25560763 DOI: 10.1038/mp.2014.167  1
2015 Felix-Ortiz AC, Burgos-Robles A, Bhagat ND, Leppla CA, Tye KM. Bidirectional modulation of anxiety-related and social behaviors by amygdala projections to the medial prefrontal cortex Neuroscience. DOI: 10.1016/j.neuroscience.2015.07.041  1
2014 Tye KM. Neural circuit reprogramming: a new paradigm for treating neuropsychiatric disease? Neuron. 83: 1259-61. PMID 25233309 DOI: 10.1016/j.neuron.2014.08.022  1
2014 Allsop SA, Vander Weele CM, Wichmann R, Tye KM. Optogenetic insights on the relationship between anxiety-related behaviors and social deficits. Frontiers in Behavioral Neuroscience. 8: 241. PMID 25076878 DOI: 10.3389/fnbeh.2014.00241  1
2014 Chuong AS, Miri ML, Busskamp V, Matthews GA, Acker LC, Sørensen AT, Young A, Klapoetke NC, Henninger MA, Kodandaramaiah SB, Ogawa M, Ramanlal SB, Bandler RC, Allen BD, Forest CR, ... ... Tye KM, et al. Noninvasive optical inhibition with a red-shifted microbial rhodopsin. Nature Neuroscience. 17: 1123-9. PMID 24997763 DOI: 10.1038/nn.3752  1
2014 Gunaydin LA, Grosenick L, Finkelstein JC, Kauvar IV, Fenno LE, Adhikari A, Lammel S, Mirzabekov JJ, Airan RD, Zalocusky KA, Tye KM, Anikeeva P, Malenka RC, Deisseroth K. Natural neural projection dynamics underlying social behavior. Cell. 157: 1535-51. PMID 24949967 DOI: 10.1016/j.cell.2014.05.017  1
2014 Beyeler A, Eckhardt CA, Tye KM. Deciphering memory function with optogenetics. Progress in Molecular Biology and Translational Science. 122: 341-90. PMID 24484707 DOI: 10.1016/B978-0-12-420170-5.00012-X  1
2014 Felix-Ortiz AC, Tye KM. Amygdala inputs to the ventral hippocampus bidirectionally modulate social behavior. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 586-95. PMID 24403157 DOI: 10.1523/JNEUROSCI.4257-13.2014  1
2014 Haws ME, Jaramillo TC, Espinosa F, Widman AJ, Stuber GD, Sparta DR, Tye KM, Russo SJ, Parada LF, Stavarache M, Kaplitt M, Bonci A, Powell CM. PTEN knockdown alters dendritic spine/protrusion morphology, not density. The Journal of Comparative Neurology. 522: 1171-90. PMID 24264880 DOI: 10.1002/cne.23488  1
2014 Lammel S, Tye KM, Warden MR. Progress in understanding mood disorders: optogenetic dissection of neural circuits. Genes, Brain, and Behavior. 13: 38-51. PMID 23682971 DOI: 10.1111/gbb.12049  1
2013 Felix-Ortiz AC, Beyeler A, Seo C, Leppla CA, Wildes CP, Tye KM. BLA to vHPC inputs modulate anxiety-related behaviors. Neuron. 79: 658-64. PMID 23972595 DOI: 10.1016/j.neuron.2013.06.016  1
2013 Kim SY, Adhikari A, Lee SY, Marshel JH, Kim CK, Mallory CS, Lo M, Pak S, Mattis J, Lim BK, Malenka RC, Warden MR, Neve R, Tye KM, Deisseroth K. Diverging neural pathways assemble a behavioural state from separable features in anxiety. Nature. 496: 219-23. PMID 23515158 DOI: 10.1038/nature12018  1
2013 Tye KM, Mirzabekov JJ, Warden MR, Ferenczi EA, Tsai HC, Finkelstein J, Kim SY, Adhikari A, Thompson KR, Andalman AS, Gunaydin LA, Witten IB, Deisseroth K. Dopamine neurons modulate neural encoding and expression of depression-related behaviour. Nature. 493: 537-41. PMID 23235822 DOI: 10.1038/nature11740  1
2013 Nieh EH, Kim SY, Namburi P, Tye KM. Optogenetic dissection of neural circuits underlying emotional valence and motivated behaviors. Brain Research. 1511: 73-92. PMID 23142759 DOI: 10.1016/j.brainres.2012.11.001  1
2012 Warden MR, Selimbeyoglu A, Mirzabekov JJ, Lo M, Thompson KR, Kim SY, Adhikari A, Tye KM, Frank LM, Deisseroth K. A prefrontal cortex-brainstem neuronal projection that controls response to behavioural challenge. Nature. 492: 428-32. PMID 23160494 DOI: 10.1038/nature11617  1
2012 Lammel S, Lim BK, Ran C, Huang KW, Betley MJ, Tye KM, Deisseroth K, Malenka RC. Input-specific control of reward and aversion in the ventral tegmental area. Nature. 491: 212-7. PMID 23064228 DOI: 10.1038/nature11527  1
2012 Tan KR, Yvon C, Turiault M, Mirzabekov JJ, Doehner J, Labouèbe G, Deisseroth K, Tye KM, Lüscher C. GABA neurons of the VTA drive conditioned place aversion. Neuron. 73: 1173-83. PMID 22445344 DOI: 10.1016/j.neuron.2012.02.015  1
2012 Tye KM, Deisseroth K. Optogenetic investigation of neural circuits underlying brain disease in animal models. Nature Reviews. Neuroscience. 13: 251-66. PMID 22430017 DOI: 10.1038/nrn3171  1
2012 Mattis J, Tye KM, Ferenczi EA, Ramakrishnan C, O'Shea DJ, Prakash R, Gunaydin LA, Hyun M, Fenno LE, Gradinaru V, Yizhar O, Deisseroth K. Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins. Nature Methods. 9: 159-72. PMID 22179551 DOI: 10.1038/nmeth.1808  1
2011 Witten IB, Steinberg EE, Lee SY, Davidson TJ, Zalocusky KA, Brodsky M, Yizhar O, Cho SL, Gong S, Ramakrishnan C, Stuber GD, Tye KM, Janak PH, Deisseroth K. Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcement. Neuron. 72: 721-33. PMID 22153370 DOI: 10.1016/j.neuron.2011.10.028  1
2011 Stuber GD, Sparta DR, Stamatakis AM, van Leeuwen WA, Hardjoprajitno JE, Cho S, Tye KM, Kempadoo KA, Zhang F, Deisseroth K, Bonci A. Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking. Nature. 475: 377-80. PMID 21716290 DOI: 10.1038/nature10194  1
2011 Berndt A, Schoenenberger P, Mattis J, Tye KM, Deisseroth K, Hegemann P, Oertner TG. High-efficiency channelrhodopsins for fast neuronal stimulation at low light levels. Proceedings of the National Academy of Sciences of the United States of America. 108: 7595-600. PMID 21504945 DOI: 10.1073/pnas.1017210108  1
2011 Tye KM, Prakash R, Kim SY, Fenno LE, Grosenick L, Zarabi H, Thompson KR, Gradinaru V, Ramakrishnan C, Deisseroth K. Amygdala circuitry mediating reversible and bidirectional control of anxiety. Nature. 471: 358-62. PMID 21389985 DOI: 10.1038/nature09820  1
2010 Stuber GD, Hopf FW, Tye KM, Chen BT, Bonci A. Neuroplastic alterations in the limbic system following cocaine or alcohol exposure. Current Topics in Behavioral Neurosciences. 3: 3-27. PMID 21161748 DOI: 10.1007/7854_2009_23  1
2010 Tye KM, Tye LD, Cone JJ, Hekkelman EF, Janak PH, Bonci A. Methylphenidate facilitates learning-induced amygdala plasticity. Nature Neuroscience. 13: 475-81. PMID 20208527 DOI: 10.1038/nn.2506  1
2010 Tye KM, Cone JJ, Schairer WW, Janak PH. Amygdala neural encoding of the absence of reward during extinction. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 116-25. PMID 20053894 DOI: 10.1523/JNEUROSCI.4240-09.2010  1
2008 Tye KM, Stuber GD, de Ridder B, Bonci A, Janak PH. Rapid strengthening of thalamo-amygdala synapses mediates cue-reward learning. Nature. 453: 1253-7. PMID 18469802 DOI: 10.1038/nature06963  1
2007 Tye KM, Janak PH. Amygdala neurons differentially encode motivation and reinforcement. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 3937-45. PMID 17428967 DOI: 10.1523/JNEUROSCI.5281-06.2007  1
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