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Paul Dent - Publications

Affiliations: 
Biochemistry Virginia Commonwealth University, Richmond, VA, United States 
Area:
Biochemistry, Cell Biology
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Year Citation  Score
2024 Booth MR, Booth L, Roberts JL, West C, Dent P. GZ17-6.02 interacts with bexarotene to kill mycosis fungoides cells. Oncotarget. 15: 124-133. PMID 38329728 DOI: 10.18632/oncotarget.28557  0.436
2023 Booth L, Roberts JL, Poklepovic A, Dent P. Autophagy as a therapeutic mechanism to kill drug-resistant cancer cells. Anti-Cancer Drugs. PMID 37843030 DOI: 10.1097/CAD.0000000000001549  0.388
2023 Booth L, Poklepovic A, Hancock JF, Dent P. Cellular responses after (neratinib plus pemetrexed) exposure in NSCLC cells. Anti-Cancer Drugs. 34: 1025-1034. PMID 37703296 DOI: 10.1097/CAD.0000000000001442  0.315
2023 Bordeaux ZA, Kwatra SG, Booth L, Dent P. A novel combination of isovanillin, curcumin, and harmine (GZ17-6.02) enhances cell death and alters signaling in actinic keratoses cells when compared to individual components and two-component combinations. Anti-Cancer Drugs. 34: 544-550. PMID 36847046 DOI: 10.1097/CAD.0000000000001425  0.377
2022 Booth L, Roberts JL, West C, Dent P. GZ17-6.02 kills prostate cancer cells and . Frontiers in Oncology. 12: 1045459. PMID 36408163 DOI: 10.3389/fonc.2022.1045459  0.392
2022 Booth L, West C, Moore RP, Hoff DV, Dent P. GZ17-6.02 and axitinib interact to kill renal carcinoma cells. Oncotarget. 13: 281-290. PMID 35136485 DOI: 10.18632/oncotarget.28189  0.405
2022 Booth L, West C, Moore RP, Von Hoff D, Dent P. GZ17-6.02 and palbociclib interact to kill ER+ breast cancer cells. Oncotarget. 13: 92-104. PMID 35035775 DOI: 10.18632/oncotarget.28177  0.385
2021 Roberts JL, Booth L, Poklepovic A, Dent P. Axitinib and HDAC Inhibitors Interact to Kill Sarcoma Cells. Frontiers in Oncology. 11: 723966. PMID 34604061 DOI: 10.3389/fonc.2021.723966  0.359
2021 Booth L, West C, Moore RP, Von Hoff D, Dent P. GZ17-6.02 and Pemetrexed Interact to Kill Osimertinib-Resistant NSCLC Cells That Express Mutant ERBB1 Proteins. Frontiers in Oncology. 11: 711043. PMID 34490108 DOI: 10.3389/fonc.2021.711043  0.38
2021 Dent P, Booth L, Poklepovic A, Kirkwood JM. Neratinib kills B-RAF V600E melanoma via ROS-dependent autophagosome formation and death receptor signaling. Pigment Cell & Melanoma Research. PMID 34482636 DOI: 10.1111/pcmr.13014  0.37
2021 Dent P, Poklepovic A, Booth L, Hancock JF. The development of multi-kinase inhibitors as pancreatic cancer therapeutics. Anti-Cancer Drugs. 32: 779-785. PMID 34397447 DOI: 10.1097/CAD.0000000000001177  0.308
2021 Dent P, Booth L, Poklepovic A, Von Hoff D, Martinez J, Zhou Y, Hancock JF. Osimertinib-resistant NSCLC cells activate ERBB2 and YAP/TAZ and are killed by neratinib. Biochemical Pharmacology. 114642. PMID 34077739 DOI: 10.1016/j.bcp.2021.114642  0.398
2021 Booth L, West C, Von Hoff D, Kirkwood JM, Dent P. GZ17-6.02 Interacts With [MEK1/2 and B-RAF Inhibitors] to Kill Melanoma Cells. Frontiers in Oncology. 11: 656453. PMID 33898322 DOI: 10.3389/fonc.2021.656453  0.396
2020 Booth L, West C, Hoff DV, Dent P. GZ17-6.02 and Doxorubicin Interact to Kill Sarcoma Cells via Autophagy and Death Receptor Signaling. Frontiers in Oncology. 10: 1331. PMID 32983965 DOI: 10.3389/Fonc.2020.01331  0.516
2020 Rayner JO, Roberts RA, Kim J, Poklepovic A, Roberts JL, Booth L, Dent P. AR12 (OSU-03012) suppresses GRP78 expression and inhibits SARS-CoV-2 replication. Biochemical Pharmacology. 114227. PMID 32966814 DOI: 10.1016/J.Bcp.2020.114227  0.367
2020 Booth L, Poklepovic A, Dent P. Neratinib decreases pro-survival responses of [sorafenib + vorinostat] in pancreatic cancer. Biochemical Pharmacology. 178: 114067. PMID 32504550 DOI: 10.1016/J.Bcp.2020.114067  0.504
2020 Dent P, Booth L, Roberts JL, Poklepovic A, Hancock JF. Corrigendum: Fingolimod Augments Monomethylfumarate Killing of GBM Cells. Frontiers in Oncology. 10: 684. PMID 32426288 DOI: 10.3389/Fonc.2020.00684  0.321
2020 West CE, Kwatra SG, Choi J, Von Hoff D, Booth L, Dent P. A novel plant-derived compound is synergistic with 5-fluorouracil and has increased apoptotic activity through autophagy in the treatment of actinic keratoses. The Journal of Dermatological Treatment. 1-7. PMID 32362152 DOI: 10.1080/09546634.2020.1764905  0.465
2020 Roberts JL, Poklepovic A, Booth L, Dent P. The multi-kinase inhibitor lenvatinib interacts with the HDAC inhibitor entinostat to kill liver cancer cells. Cellular Signalling. 109573. PMID 32087304 DOI: 10.1016/J.Cellsig.2020.109573  0.534
2020 Dent P, Booth L, Roberts JL, Poklepovic A, Hancock JF. Fingolimod Augments Monomethylfumarate Killing of GBM Cells. Frontiers in Oncology. 10: 22. PMID 32047722 DOI: 10.3389/Fonc.2020.00022  0.5
2020 Dent P, Booth L, Roberts JL, Poklepovic A, Hancock JF. (Curcumin+sildenafil) enhances the efficacy of 5FU and anti-PD1 therapies in vivo. Journal of Cellular Physiology. PMID 31985048 DOI: 10.1002/Jcp.29580  0.448
2020 Booth L, Roberts JL, West C, Von Hoff D, Dent P. GZ17-6.02 initiates DNA damage causing autophagosome-dependent HDAC degradation resulting in enhanced anti-PD1 checkpoint inhibitory antibody efficacy. Journal of Cellular Physiology. PMID 31951027 DOI: 10.1002/Jcp.29464  0.474
2020 Dent P, Booth L, Poklepovic A, Martinez J, Hoff DV, Hancock JF. Neratinib degrades MST4 via autophagy that reduces membrane stiffness and is essential for the inactivation of PI3K, ERK1/2, and YAP/TAZ signaling. Journal of Cellular Physiology. PMID 31912905 DOI: 10.1002/Jcp.29443  0.495
2020 Dent P, Booth L, Poklepovic A, Hoff DV, Hancock JF. Enhanced signaling via ERBB3/PI3K plays a compensatory survival role in pancreatic tumor cells exposed to [neratinib + valproate]. Cellular Signalling. 68: 109525. PMID 31911180 DOI: 10.1016/J.Cellsig.2020.109525  0.469
2020 Dent P, Booth L, Poklepovic A. Metabolism of Histone Deacetylase Proteins Opsonizes Tumor Cells to Checkpoint Inhibitory Immunotherapies. Immunometabolism. 2. PMID 31885880 DOI: 10.20900/immunometab20200002  0.355
2020 West C, Booth L, Hoff DV, Kwatra S, Dent P. 575 GZ17-6.02 promotes autophagy and cell death in actinic keratoses via ATM-dependent mTOR inhibition Journal of Investigative Dermatology. 140. DOI: 10.1016/J.Jid.2020.03.585  0.445
2019 Dent P. Investigational CHK1 inhibitors in early phase clinical trials for the treatment of cancer. Expert Opinion On Investigational Drugs. 28: 1095-1100. PMID 31783714 DOI: 10.1080/13543784.2019.1694661  0.44
2019 Booth L, Poklepovic A, Dent P. Not the comfy chair! Cancer drugs that act against multiple active sites. Expert Opinion On Therapeutic Targets. PMID 31709855 DOI: 10.1080/14728222.2019.1691526  0.449
2019 Booth LA, Roberts JL, Dent P. The role of cell signaling in the crosstalk between autophagy and apoptosis in the regulation of tumor cell survival in response to sorafenib and neratinib. Seminars in Cancer Biology. PMID 31644944 DOI: 10.1016/J.Semcancer.2019.10.013  0.507
2019 Dent P, Booth L, Poklepovic A, Hancock JF. Signaling alterations caused by drugs and autophagy. Cellular Signalling. 109416. PMID 31520735 DOI: 10.1016/J.Cellsig.2019.109416  0.484
2019 Booth L, Roberts JL, Poklepovic A, Dent P. The Lethality of [Pazopanib + HDAC Inhibitors] Is Enhanced by Neratinib. Frontiers in Oncology. 9: 650. PMID 31380285 DOI: 10.3389/Fonc.2019.00650  0.535
2019 Dent P, Booth L, Roberts JL, Liu J, Poklepovic A, Lalani AS, Tuveson D, Martinez J, Hancock JF. Neratinib inhibits Hippo/YAP signaling, reduces mutant K-RAS expression, and kills pancreatic and blood cancer cells. Oncogene. PMID 31253872 DOI: 10.1038/S41388-019-0849-8  0.409
2019 Dasmahapatra G, Lembersky D, Son MP, Patel H, Peterson D, Attkisson E, Fisher RI, Friedberg JW, Dent P, Grant S. Retraction: Obatoclax Interacts Synergistically with the Irreversible Proteasome Inhibitor Carfilzomib in GC- and ABC-DLBCL Cells and . Molecular Cancer Therapeutics. 18: 1180. PMID 31160510 DOI: 10.1158/1535-7163.MCT-19-0470  0.305
2019 Dasmahapatra G, Lembersky D, Son MP, Attkisson E, Dent P, Fisher RI, Friedberg JW, Grant S. Retraction: Carfilzomib Interacts Synergistically with Histone Deacetylase Inhibitors in Mantle Cell Lymphoma Cells and . Molecular Cancer Therapeutics. 18: 1179. PMID 31160509 DOI: 10.1158/1535-7163.MCT-19-0469  0.302
2019 Dasmahapatra G, Nguyen TK, Dent P, Grant S. Corrigendum to "Adaphostin and bortezomib induce oxidative injury and apoptosis in imatinib mesylate-resistant hematopoietic cells expressing mutant forms of Bcr/Abl" [Leuk. Res. 30 (2006) 1263-1272]. Leukemia Research. PMID 31079870 DOI: 10.1016/J.Leukres.2019.03.002  0.385
2018 Booth L, Roberts JL, Poklepovic A, Dent P. NEDD4 over-expression regulates the afatinib resistant phenotype of NSCLC cells. Oncology Signaling. 1: 19-30. PMID 30740589 DOI: 10.1016/J.Onsig.2017.07.001  0.435
2018 Booth L, Roberts JL, Sander C, Lalani AS, Kirkwood JM, Hancock JF, Poklepovic A, Dent P. Neratinib and entinostat combine to rapidly reduce the expression of K-RAS, N-RAS, Gα and Gα and kill uveal melanoma cells. Cancer Biology & Therapy. 1-11. PMID 30571927 DOI: 10.1080/15384047.2018.1551747  0.48
2018 Booth L, Roberts JL, Spiegel S, Poklepovic A, Dent P. Fingolimod augments Pemetrexed killing of non-small cell lung cancer and overcomes resistance to ERBB inhibition. Cancer Biology & Therapy. 1-11. PMID 30388910 DOI: 10.1080/15384047.2018.1538616  0.477
2018 Booth L, Roberts JL, Rais R, Cutler RE, Diala I, Lalani AS, Hancock JF, Poklepovic A, Dent P. Neratinib augments the lethality of [regorafenib + sildenafil]. Journal of Cellular Physiology. PMID 30203445 DOI: 10.1002/Jcp.27276  0.475
2018 Booth L, Roberts JL, Rais R, Cutler RE, Diala I, Lalani AS, Poklepovic A, Dent P. Palbociclib augments Neratinib killing of tumor cells that is further enhanced by HDAC inhibition. Cancer Biology & Therapy. 1-12. PMID 30183517 DOI: 10.1080/15384047.2018.1507665  0.506
2018 Booth L, Roberts JL, Poklepovic A, Dent P. Prior exposure of pancreatic tumors to [sorafenib + vorinostat] enhances the efficacy of an anti-PD-1 antibody. Cancer Biology & Therapy. 1-13. PMID 30142009 DOI: 10.1080/15384047.2018.1507258  0.429
2018 Booth L, Roberts J, Poklepovic A, Dent P. The CHK1 inhibitor SRA737 synergizes with PARP1 inhibitors to kill carcinoma cells. Cancer Biology & Therapy. 1-11. PMID 30024813 DOI: 10.1080/15384047.2018.1472189  0.592
2018 Booth L, Roberts JL, Rais R, Poklepovic A, Dent P. Valproate augments Niraparib killing of tumor cells. Cancer Biology & Therapy. PMID 29923797 DOI: 10.1080/15384047.2018.1472190  0.575
2018 Booth L, Roberts JL, Rais R, Kirkwood J, Avogadri-Connors F, Cutler RE, Lalani AS, Poklepovic A, Dent P. [Neratinib + Valproate] exposure permanently reduces ERBB1 and RAS expression in 4T1 mammary tumors and enhances M1 macrophage infiltration. Oncotarget. 9: 6062-6074. PMID 29464055 DOI: 10.18632/Oncotarget.23681  0.428
2018 Booth L, Roberts JL, Kirkwood J, Poklepovic A, Dent P. Unconventional Approaches to Modulating the Immunogenicity of Tumor Cells. Advances in Cancer Research. 137: 1-15. PMID 29405973 DOI: 10.1016/Bs.Acr.2017.11.004  0.493
2018 Booth L, Roberts JL, Samuel P, Avogadri-Connors F, Cutler RE, Lalani AS, Poklepovic A, Dent P. The irreversible ERBB1/2/4 inhibitor neratinib interacts with the PARP1 inhibitor niraparib to kill ovarian cancer cells. Cancer Biology & Therapy. 0. PMID 29405820 DOI: 10.1080/15384047.2018.1436024  0.537
2018 Lima S, Takabe K, Newton J, Saurabh K, Young MM, Leopoldino AM, Hait NC, Roberts JL, Wang HG, Dent P, Milstien S, Booth L, Spiegel S. TP53 is required for BECN1- and ATG5-dependent cell death induced by sphingosine kinase 1 inhibition. Autophagy. 1-50. PMID 29368980 DOI: 10.1080/15548627.2018.1429875  0.569
2018 Booth L, Roberts JL, Avogadri-Connors F, CutlerJr RE, Lalani AS, Poklepovic A, Dent P. The irreversible ERBB1/2/4 inhibitor neratinib interacts with the BCL-2 inhibitor venetoclax to kill mammary cancer cells. Cancer Biology & Therapy. 0. PMID 29333953 DOI: 10.1080/15384047.2018.1423927  0.556
2018 Booth L, Roberts J, Poklepovic A, Hansen RJ, Strouse B, Milutinovic S, Hassig C, Dent P. Abstract 1853: The Chk1 inhibitor, SRA737, synergizes with niraparib to kill cancer cells via multiple cell death pathways Cancer Research. 78: 1853-1853. DOI: 10.1158/1538-7445.Am2018-1853  0.522
2017 Booth L, Roberts JL, Poklepovic A, Kirkwood J, Sander C, Avogadri-Connors F, Cutler RE, Lalani AS, Dent P. The levels of mutant K-RAS and mutant N-RAS are rapidly reduced in a Beclin1 / ATG5 -dependent fashion by the irreversible ERBB1/2/4 inhibitor neratinib. Cancer Biology & Therapy. 1-6. PMID 29219657 DOI: 10.1080/15384047.2017.1394556  0.379
2017 Booth L, Roberts JL, Poklepovic A, Avogadri-Connors F, Cutler RE, Lalani AS, Dent P. HDAC inhibitors enhance neratinib activity and when combined enhance the actions of an anti-PD-1 immunomodulatory antibody in vivo. Oncotarget. 8: 90262-90277. PMID 29163826 DOI: 10.18632/Oncotarget.21660  0.47
2017 Booth L, Roberts JL, Poklepovic A, Kirkwood J, Dent P. HDAC inhibitors enhance the immunotherapy response of melanoma cells. Oncotarget. 8: 83155-83170. PMID 29137331 DOI: 10.18632/Oncotarget.17950  0.461
2017 Booth L, Roberts JL, Poklepovic A, Dent P. [pemetrexed + sildenafil], via autophagy-dependent HDAC down-regulation, enhances the immunotherapy response of NSCLC cells. Cancer Biology & Therapy. 0. PMID 28812434 DOI: 10.1080/15384047.2017.1362511  0.479
2017 Booth L, Roberts JL, Poklepovic A, Kirkwood J, Dent P. HDAC inhibitors enhance the immunotherapy response of melanoma cells. Oncotarget. PMID 28575876 DOI: 10.18632/oncotarget.17950  0.354
2017 Booth L, Roberts JL, Sander C, Lee J, Kirkwood JM, Poklepovic A, Dent P. The HDAC inhibitor AR42 interacts with pazopanib to kill trametinib/dabrafenib-resistant melanoma cells in vitro and in vivo. Oncotarget. PMID 28146421 DOI: 10.18632/Oncotarget.14829  0.542
2017 Booth L, Roberts JL, Poklepovic A, Dent P. PDE5 inhibitors enhance the lethality of [pemetrexed + sorafenib]. Oncotarget. PMID 28088782 DOI: 10.18632/Oncotarget.14562  0.561
2017 Shafer DA, Chen Z, Harris T, Tombes MB, Shrader E, Strickler K, Ryan AA, Dent P, Malkin MG. Phase I trial of dimethyl fumarate, temozolomide, and radiation therapy in glioblastoma multiforme. Journal of Clinical Oncology. 35: 2060-2060. DOI: 10.1200/Jco.2017.35.15_Suppl.2060  0.309
2016 Booth L, Roberts JL, Poklepovic A, Gordon S, Dent P. PDE5 inhibitors enhance the lethality of pemetrexed through inhibition of multiple chaperone proteins and via the actions of cyclic GMP and nitric oxide. Oncotarget. PMID 27903966 DOI: 10.18632/Oncotarget.13640  0.521
2016 Zhang G, Park MA, Mitchell C, Walker T, Hamed H, Studer E, Graf M, Rahmani M, Gupta S, Hylemon PB, Fisher PB, Grant S, Dent P. Multiple cyclin kinase inhibitors promote bile acid-induced apoptosis and autophagy in primary hepatocytes via p53-CD95-dependent signaling. The Journal of Biological Chemistry. 291: 20823. PMID 27664064 DOI: 10.1074/jbc.A116.803444  0.819
2016 Shapiro BA, Vu NT, Shultz MD, Shultz JC, Mietla JA, Gouda MM, Yacoub A, Dent P, Fisher PB, Park MA, Chalfant CE. Melanoma differentiation associated gene 7/IL-24 exerts cytotoxic effects by altering the alternative splicing of Bcl-x pre-mRNA via the SRC/PKCδ signaling axis. The Journal of Biological Chemistry. PMID 27519412 DOI: 10.1074/Jbc.M116.737569  0.398
2016 Tavallai M, Booth L, Roberts JL, Poklepovic A, Dent P. Rationally Repurposing Ruxolitinib (Jakafi (®)) as a Solid Tumor Therapeutic. Frontiers in Oncology. 6: 142. PMID 27379204 DOI: 10.3389/Fonc.2016.00142  0.531
2016 Booth L, Albers T, Roberts JL, Tavallai M, Poklepovic A, Lebedyeva IO, Dent P. Multi-kinase inhibitors interact with sildenafil and ERBB1/2/4 inhibitors to kill tumor cells in vitro and in vivo. Oncotarget. PMID 27259258 DOI: 10.18632/Oncotarget.9752  0.509
2016 Poklepovic A, Gordon S, Shafer DA, Roberts JD, Bose P, Geyer CE, McGuire WP, Tombes MB, Shrader E, Strickler K, Quigley M, Wan W, Kmieciak M, Massey HD, Booth L, ... ... Dent P, et al. Phase I study of pemetrexed with sorafenib in advanced solid tumors. Oncotarget. PMID 27213589 DOI: 10.18632/Oncotarget.9434  0.33
2016 Booth L, Roberts JL, Ecroyd H, Tritsch SR, Bavari S, Reid SP, Proniuk S, Zukiwski A, Jacob A, Sepúlveda CS, Giovannoni F, García CC, Damonte E, González-Gallego J, Tuñón MJ, ... Dent P, et al. AR-12 inhibits multiple chaperones concomitant with stimulating autophagosome formation collectively preventing virus replication. Journal of Cellular Physiology. PMID 27187154 DOI: 10.1002/Jcp.25431  0.345
2016 Yu C, Dasmahapatra G, Dent P, Grant S. Synergistic interactions between MEK1/2 and histone deacetylase inhibitors in BCR/ABL+ human leukemia cells. Leukemia. PMID 27055874 DOI: 10.1038/Leu.2016.7  0.498
2016 Booth L, Roberts JL, Tavallai M, Chuckalovcak J, Stringer DK, Koromilas AE, Boone DL, McGuire WP, Poklepovic A, Dent P. [Pemetrexed + Sorafenib] lethality is increased by inhibition of ERBB1/2/3-PI3K-NFκB compensatory survival signaling. Oncotarget. PMID 27015562 DOI: 10.18632/Oncotarget.8281  0.52
2016 Tavallai M, Booth L, Roberts JL, McGuire WP, Poklepovic A, Dent P. Ruxolitinib synergizes with DMF to kill via BIM+BAD-induced mitochondrial dysfunction and via reduced SOD2/TRX expression and ROS. Oncotarget. PMID 26981780 DOI: 10.18632/Oncotarget.8039  0.526
2016 Booth L, Roberts JL, Tavallai M, Webb T, Leon D, Chen J, McGuire WP, Poklepovic A, Dent P. The afatinib resistance of in vivo generated H1975 lung cancer cell clones is mediated by SRC/ERBB3/c-KIT/c-MET compensatory survival signaling. Oncotarget. PMID 26934000 DOI: 10.18632/Oncotarget.7746  0.436
2016 Booth L, Shuch B, Albers T, Roberts JL, Tavallai M, Proniuk S, Zukiwski A, Wang D, Chen CS, Bottaro D, Ecroyd H, Lebedyeva IO, Dent P. Multi-kinase inhibitors can associate with heat shock proteins through their NH2-termini by which they suppress chaperone function. Oncotarget. PMID 26887051 DOI: 10.18632/Oncotarget.7349  0.436
2016 Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Dent P, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356  0.558
2015 Das A, Durrant D, Mitchell C, Dent P, Batra SK, Kukreja RC. Sildenafil (Viagra) sensitizes prostate cancer cells to doxorubicin-mediated apoptosis through CD95. Oncotarget. PMID 26716643 DOI: 10.18632/Oncotarget.6749  0.686
2015 Webb T, Carter J, Roberts JL, Poklepovic A, McGuire WP, Booth L, Dent P. Celecoxib enhances [sorafenib + sildenafil] lethality in cancer cells and reverts platinum chemotherapy resistance. Cancer Biology & Therapy. 1-11. PMID 26417912 DOI: 10.1080/15384047.2015.1099769  0.498
2015 Nahta R, Al-Mulla F, Al-Temaimi R, Amedei A, Andrade-Vieira R, Bay S, G Brown D, Calaf GM, Castellino RC, Cohen-Solal KA, Colacci A, Cruickshanks N, Dent P, Di Fiore R, Forte S, et al. Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression. Carcinogenesis. 36: S2-S18. PMID 26106139 DOI: 10.1093/Carcin/Bgv028  0.334
2015 Durrant DE, Das A, Dyer S, Tavallai S, Dent P, Kukreja RC. Targeted Inhibition of Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Sensitizes Pancreatic Cancer Cells to Doxorubicin without Exacerbating Cardiac Toxicity. Molecular Pharmacology. 88: 512-23. PMID 26101222 DOI: 10.1124/Mol.115.099143  0.542
2015 Roberts JL, Tavallai M, Nourbakhsh A, Fidanza A, Cruz-Luna T, Smith E, Siembida P, Plamondon P, Cycon KA, Doern CD, Booth L, Dent P. GRP78/Dna K Is a Target for Nexavar/Stivarga/Votrient in the Treatment of Human Malignancies, Viral Infections and Bacterial Diseases. Journal of Cellular Physiology. 230: 2552-78. PMID 25858032 DOI: 10.1002/Jcp.25014  0.4
2015 Cruickshanks N, Roberts JL, Bareford MD, Tavallai M, Poklepovic A, Booth L, Spiegel S, Dent P. Differential regulation of autophagy and cell viability by ceramide species. Cancer Biology & Therapy. 16: 733-42. PMID 25803131 DOI: 10.1080/15384047.2015.1026509  0.843
2015 Booth L, Roberts JL, Tavallai M, Nourbakhsh A, Chuckalovcak J, Carter J, Poklepovic A, Dent P. OSU-03012 and Viagra Treatment Inhibits the Activity of Multiple Chaperone Proteins and Disrupts the Blood-Brain Barrier: Implications for Anti-Cancer Therapies. Journal of Cellular Physiology. 230: 1982-98. PMID 25736380 DOI: 10.1002/Jcp.24977  0.496
2015 Tavallai M, Hamed HA, Roberts JL, Cruickshanks N, Chuckalovcak J, Poklepovic A, Booth L, Dent P. Nexavar/Stivarga and viagra interact to kill tumor cells. Journal of Cellular Physiology. 230: 2281-98. PMID 25704960 DOI: 10.1002/Jcp.24961  0.763
2015 Booth L, Roberts JL, Dent P. HSPA5/Dna K may be a useful target for human disease therapies. Dna and Cell Biology. 34: 153-8. PMID 25689303 DOI: 10.1089/Dna.2015.2808  0.365
2015 Booth L, Roberts JL, Cash DR, Tavallai S, Jean S, Fidanza A, Cruz-Luna T, Siembiba P, Cycon KA, Cornelissen CN, Dent P. GRP78/BiP/HSPA5/Dna K is a universal therapeutic target for human disease. Journal of Cellular Physiology. 230: 1661-76. PMID 25546329 DOI: 10.1002/Jcp.24919  0.336
2015 Sarkar S, Quinn BA, Shen X, Dent P, Das SK, Emdad L, Sarkar D, Fisher PB. Reversing translational suppression and induction of toxicity in pancreatic cancer cells using a chemoprevention gene therapy approach. Molecular Pharmacology. 87: 286-95. PMID 25452327 DOI: 10.1124/Mol.114.094375  0.397
2015 Gurbuz N, Park MA, Dent P, Abdel Mageed AB, Sikka SC, Baykal A. Cystine dimethyl ester induces apoptosis through regulation of PKC-δ and PKC-ε in prostate cancer cells. Anti-Cancer Agents in Medicinal Chemistry. 15: 217-27. PMID 25410184 DOI: 10.2174/1871520614666141120121901  0.468
2015 Booth L, Roberts JL, Cruickshanks N, Tavallai S, Webb T, Samuel P, Conley A, Binion B, Young HF, Poklepovic A, Spiegel S, Dent P. PDE5 inhibitors enhance celecoxib killing in multiple tumor types. Journal of Cellular Physiology. 230: 1115-27. PMID 25303541 DOI: 10.1002/Jcp.24843  0.536
2015 Hamed HA, Tavallai S, Grant S, Poklepovic A, Dent P. Sorafenib/regorafenib and lapatinib interact to kill CNS tumor cells. Journal of Cellular Physiology. 230: 131-9. PMID 24911215 DOI: 10.1002/Jcp.24689  0.775
2015 Poklepovic AS, Shafer DA, Roberts JD, Geyer CE, Dent P, Moran R, Tombes MB, Shrader E, Strickler K, Wan W. Phase I study of pemetrexed and sorafenib in advanced solid tumors. Journal of Clinical Oncology. 33: 2586-2586. DOI: 10.1200/Jco.2015.33.15_Suppl.2586  0.417
2015 Tavallai M, Booth L, Roberts JL, Poklepovic A, Dent P. Abstract LB-094: Regorafenib and sildenafil interact to kill tumor cells Cancer Research. 75. DOI: 10.1158/1538-7445.Am2015-Lb-094  0.543
2015 Roberts JL, Tavallai S, Poklepovic A, Booth L, Dent P. Abstract 3503: Gilenya and Alimta interact to kill breast cancer cells Cancer Research. 75: 3503-3503. DOI: 10.1158/1538-7445.Am2015-3503  0.323
2015 Booth LA, Roberts JL, Dent P. Abstract 1741: GRP78 / BiP / HSPA5 expression and those of other chaperone proteins is rapidly degraded by OSU-03012 and Viagra exposure: Implications for anti-cancer and anti-pathogen therapies Cancer Research. 75: 1741-1741. DOI: 10.1158/1538-7445.Am2015-1741  0.467
2014 Booth L, Cruickshanks N, Tavallai S, Roberts JL, Peery M, Poklepovic A, Dent P. Regulation of dimethyl-fumarate toxicity by proteasome inhibitors. Cancer Biology & Therapy. 15: 1646-57. PMID 25482938 DOI: 10.4161/15384047.2014.967992  0.515
2014 Booth L, Roberts JL, Cruickshanks N, Grant S, Poklepovic A, Dent P. Regulation of OSU-03012 toxicity by ER stress proteins and ER stress-inducing drugs. Molecular Cancer Therapeutics. 13: 2384-98. PMID 25103559 DOI: 10.1158/1535-7163.Mct-14-0172  0.517
2014 Menezes ME, Bhatia S, Bhoopathi P, Das SK, Emdad L, Dasgupta S, Dent P, Wang XY, Sarkar D, Fisher PB. MDA-7/IL-24: multifunctional cancer killing cytokine. Advances in Experimental Medicine and Biology. 818: 127-53. PMID 25001534 DOI: 10.1007/978-1-4471-6458-6_6  0.406
2014 Roberts JL, Booth L, Conley A, Cruickshanks N, Malkin M, Kukreja RC, Grant S, Poklepovic A, Dent P. PDE5 inhibitors enhance the lethality of standard of care chemotherapy in pediatric CNS tumor cells. Cancer Biology & Therapy. 15: 758-67. PMID 24651037 DOI: 10.4161/Cbt.28553  0.498
2014 Dent P. Met in lung cancer. Cancer Biology & Therapy. 15: 653-4. PMID 24618893 DOI: 10.4161/Cbt.28504  0.407
2014 Dent P. New methods to control neuroblastoma growth. Cancer Biology & Therapy. 15: 481-2. PMID 24618834 DOI: 10.4161/Cbt.28465  0.438
2014 Tavallai S, Hamed HA, Grant S, Poklepovic A, Dent P. Pazopanib and HDAC inhibitors interact to kill sarcoma cells. Cancer Biology & Therapy. 15: 578-85. PMID 24556916 DOI: 10.4161/Cbt.28163  0.739
2014 Bhatia S, Emdad L, Das SK, Hamed H, Dent P, Sarkar D, Fisher PB. Non-BRAF targeted therapies for melanoma: protein kinase inhibitors in Phase II clinical trials. Expert Opinion On Investigational Drugs. 23: 489-500. PMID 24502370 DOI: 10.1517/13543784.2014.884558  0.647
2014 Dent P. Not so WEE: targeting G₂/M to kill mesothelioma cells. Cancer Biology & Therapy. 15: 351-2. PMID 24496096 DOI: 10.4161/Cbt.27851  0.41
2014 Dent P. Crosstalk between ERK, AKT, and cell survival. Cancer Biology & Therapy. 15: 245-6. PMID 24424114 DOI: 10.4161/Cbt.27541  0.4
2014 Booth L, Roberts JL, Cruickshanks N, Conley A, Durrant DE, Das A, Fisher PB, Kukreja RC, Grant S, Poklepovic A, Dent P. Phosphodiesterase 5 inhibitors enhance chemotherapy killing in gastrointestinal/genitourinary cancer cells. Molecular Pharmacology. 85: 408-19. PMID 24353313 DOI: 10.1124/Mol.113.090043  0.527
2014 Booth L, Roberts JL, Conley A, Cruickshanks N, Ridder T, Grant S, Poklepovic A, Dent P. HDAC inhibitors enhance the lethality of low dose salinomycin in parental and stem-like GBM cells. Cancer Biology & Therapy. 15: 305-16. PMID 24351423 DOI: 10.4161/Cbt.27309  0.532
2014 Dent P. Multi-kinase inhibition in ovarian cancer. Cancer Biology & Therapy. 15: 1-2. PMID 24309512 DOI: 10.4161/Cbt.26708  0.519
2014 Booth LA, Tavallai S, Hamed HA, Cruickshanks N, Dent P. The role of cell signalling in the crosstalk between autophagy and apoptosis. Cellular Signalling. 26: 549-55. PMID 24308968 DOI: 10.1016/J.Cellsig.2013.11.028  0.696
2014 Kegelman TP, Das SK, Hu B, Bacolod MD, Fuller CE, Menezes ME, Emdad L, Dasgupta S, Baldwin AS, Bruce JN, Dent P, Pellecchia M, Sarkar D, Fisher PB. MDA-9/syntenin is a key regulator of glioma pathogenesis. Neuro-Oncology. 16: 50-61. PMID 24305713 DOI: 10.1093/Neuonc/Not157  0.386
2014 Sarkar S, Azab B, Quinn BA, Shen X, Dent P, Klibanov AL, Emdad L, Das SK, Sarkar D, Fisher PB. Chemoprevention gene therapy (CGT) of pancreatic cancer using perillyl alcohol and a novel chimeric serotype cancer terminator virus. Current Molecular Medicine. 14: 125-40. PMID 24236457 DOI: 10.2174/1566524013666131118110827  0.432
2014 Azab BM, Dash R, Das SK, Bhutia SK, Sarkar S, Shen XN, Quinn BA, Dent P, Dmitriev IP, Wang XY, Curiel DT, Pellecchia M, Reed JC, Sarkar D, Fisher PB. Enhanced prostate cancer gene transfer and therapy using a novel serotype chimera cancer terminator virus (Ad.5/3-CTV). Journal of Cellular Physiology. 229: 34-43. PMID 23868767 DOI: 10.1002/Jcp.24408  0.337
2014 Cruickshanks NA, Hamed HA, Booth LA, Tavallai S, Sajithlal GB, Grant S, Poklepovic A, Dent P. Abstract 796: Histone deacetylase inhibitors restore toxic BH3 domain protein expression in anoikis-resistant mammary and brain cancer stem cells, thereby enhancing the response to anti-ERBB1/ERBB2 therapy Cancer Research. 74: 796-796. DOI: 10.1158/1538-7445.Am2014-796  0.746
2014 Booth LA, Cruickshanks NA, Sajithlal GB, Hamed HA, Tavallai S, Syed J, Grant S, Poklepovic A, Dent P. Abstract 2690: Sorafenib/regorafenib and phosphatidyl inositol 3 kinase/thymoma viral proto-oncogene inhibition interact to kill tumor cells Cancer Research. 74: 2690-2690. DOI: 10.1158/1538-7445.Am2014-2690  0.797
2013 Hamed HA, Das SK, Sokhi UK, Park MA, Cruickshanks N, Archer K, Ogretmen B, Grant S, Sarkar D, Fisher PB, Dent P. Combining histone deacetylase inhibitors with MDA-7/IL-24 enhances killing of renal carcinoma cells. Cancer Biology & Therapy. 14: 1039-49. PMID 24025359 DOI: 10.4161/Cbt.26110  0.706
2013 Dent P. ERK plays the baddie (again). Cancer Biology & Therapy. 14: 997-8. PMID 24025356 DOI: 10.4161/Cbt.26377  0.475
2013 Dent P. Arsenic in leukemia: a RSKy business. Cancer Biology & Therapy. 14: 871-2. PMID 24025257 DOI: 10.4161/Cbt.26159  0.379
2013 Dent P. PARP inhibitors are not all equal. Cancer Biology & Therapy. 14: 873-4. PMID 24025256 DOI: 10.4161/Cbt.26160  0.414
2013 Dent P. Janus-faced Kupffer cells in tumor metastasis. Cancer Biology & Therapy. 14: 875-6. PMID 24025255 DOI: 10.4161/Cbt.26161  0.42
2013 Dent P. Non-canonical p53 signaling to promote invasion. Cancer Biology & Therapy. 14: 879-80. PMID 24025254 DOI: 10.4161/Cbt.26174  0.33
2013 Dent P. Multi-kinase modulation for colon cancer therapy. Cancer Biology & Therapy. 14: 877-8. PMID 24025253 DOI: 10.4161/Cbt.26176  0.5
2013 Dent P. Ceramide in the prostate. Cancer Biology & Therapy. 14: 881-2. PMID 24025252 DOI: 10.4161/Cbt.26212  0.427
2013 Cruickshanks N, Hamed HA, Booth L, Tavallai S, Syed J, Sajithlal GB, Grant S, Poklepovic A, Dent P. Histone deacetylase inhibitors restore toxic BH3 domain protein expression in anoikis-resistant mammary and brain cancer stem cells, thereby enhancing the response to anti-ERBB1/ERBB2 therapy. Cancer Biology & Therapy. 14: 982-96. PMID 24025251 DOI: 10.4161/Cbt.26234  0.751
2013 Zhang Q, Raje V, Yakovlev VA, Yacoub A, Szczepanek K, Meier J, Derecka M, Chen Q, Hu Y, Sisler J, Hamed H, Lesnefsky EJ, Valerie K, Dent P, Larner AC. Mitochondrial localized Stat3 promotes breast cancer growth via phosphorylation of serine 727. The Journal of Biological Chemistry. 288: 31280-8. PMID 24019511 DOI: 10.1074/Jbc.M113.505057  0.732
2013 Dent P. FADD the bad in head and neck cancer. Cancer Biology & Therapy. 14: 780-1. PMID 23974629 DOI: 10.4161/Cbt.26151  0.389
2013 Dent P. The multi-hit hypothesis in basal-like breast cancer. Cancer Biology & Therapy. 14: 778-9. PMID 23974512 DOI: 10.4161/Cbt.26140  0.378
2013 Dent P. HDACIs and the inhibition of invasive potential. Cancer Biology & Therapy. 14: 776-7. PMID 23974427 DOI: 10.4161/Cbt.26139  0.538
2013 Dent P. The flip side of doxorubicin: Inflammatory and tumor promoting cytokines. Cancer Biology & Therapy. 14: 774-5. PMID 23974349 DOI: 10.4161/Cbt.26125  0.426
2013 Booth L, Cruickshanks N, Ridder T, Dai Y, Grant S, Dent P. PARP and CHK inhibitors interact to cause DNA damage and cell death in mammary carcinoma cells. Cancer Biology & Therapy. 14: 458-65. PMID 23917378 DOI: 10.4161/Cbt.24424  0.489
2013 Sajithlal GB, Hamed HA, Cruickshanks N, Booth L, Tavallai S, Syed J, Grant S, Poklepovic A, Dent P. Sorafenib/regorafenib and phosphatidyl inositol 3 kinase/thymoma viral proto-oncogene inhibition interact to kill tumor cells. Molecular Pharmacology. 84: 562-71. PMID 23877009 DOI: 10.1124/Mol.113.088005  0.785
2013 Bhutia SK, Mukhopadhyay S, Sinha N, Das DN, Panda PK, Patra SK, Maiti TK, Mandal M, Dent P, Wang XY, Das SK, Sarkar D, Fisher PB. Autophagy: cancer's friend or foe? Advances in Cancer Research. 118: 61-95. PMID 23768510 DOI: 10.1016/B978-0-12-407173-5.00003-0  0.447
2013 Bhutia SK, Das SK, Azab B, Menezes ME, Dent P, Wang XY, Sarkar D, Fisher PB. Targeting breast cancer-initiating/stem cells with melanoma differentiation-associated gene-7/interleukin-24. International Journal of Cancer. Journal International Du Cancer. 133: 2726-36. PMID 23720015 DOI: 10.1002/Ijc.28289  0.433
2013 Hamed HA, Yamaguchi Y, Fisher PB, Grant S, Dent P. Sorafenib and HDAC inhibitors synergize with TRAIL to kill tumor cells. Journal of Cellular Physiology. 228: 1996-2005. PMID 23674352 DOI: 10.1002/Jcp.24362  0.782
2013 Hamed HA, Yacoub A, Park MA, Archer K, Das SK, Sarkar D, Grant S, Fisher PB, Dent P. Histone deacetylase inhibitors interact with melanoma differentiation associated-7/interleukin-24 to kill primary human glioblastoma cells. Molecular Pharmacology. 84: 171-81. PMID 23661648 DOI: 10.1124/Mol.113.086553  0.699
2013 Dasmahapatra G, Patel H, Dent P, Fisher RI, Friedberg J, Grant S. The Bruton tyrosine kinase (BTK) inhibitor PCI-32765 synergistically increases proteasome inhibitor activity in diffuse large-B cell lymphoma (DLBCL) and mantle cell lymphoma (MCL) cells sensitive or resistant to bortezomib. British Journal of Haematology. 161: 43-56. PMID 23360303 DOI: 10.1111/Bjh.12206  0.5
2013 Das SK, Bhutia SK, Azab B, Kegelman TP, Peachy L, Santhekadur PK, Dasgupta S, Dash R, Dent P, Grant S, Emdad L, Pellecchia M, Sarkar D, Fisher PB. MDA-9/syntenin and IGFBP-2 promote angiogenesis in human melanoma. Cancer Research. 73: 844-54. PMID 23233738 DOI: 10.1158/0008-5472.Can-12-1681  0.465
2013 Thomas S, Quinn BA, Das SK, Dash R, Emdad L, Dasgupta S, Wang XY, Dent P, Reed JC, Pellecchia M, Sarkar D, Fisher PB. Targeting the Bcl-2 family for cancer therapy. Expert Opinion On Therapeutic Targets. 17: 61-75. PMID 23173842 DOI: 10.1517/14728222.2013.733001  0.363
2013 Kegelman TP, Das SK, Hu B, Menezes M, Emdad L, Dasgupta S, Baldwin AS, Bruce JN, Dent P, Pellecchia M, Sarkar D, Fisher PB. Abstract B85: MDA-9/syntenin is a key regulator of glioma pathogenesis Cancer Research. 73: 2618-2618. DOI: 10.1158/1538-7445.Tim2013-B85  0.464
2013 Sarkar S, Azab B, Quinn BA, Shen X, Dent P, Klibanov AL, Emdad L, Das SK, Sarkar D, Fisher PB. Abstract LB-315: Chemoprevention gene therapy (CGT) approach for pancreatic cancer. Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Lb-315  0.449
2013 Das SK, Kegelman TP, Santhekadur PK, Dasgupta S, Dent P, Grant S, Emdad L, Sarkar D, Fisher PB, Pellecchia M. Abstract 3902: MDA-9/syntenin and IGFBP-2 promote angiogenesis in human melanoma. Cancer Research. 73: 3902-3902. DOI: 10.1158/1538-7445.Am2013-3902  0.458
2013 Santhekadur PK, Gredler R, Akiel M, Dent P, Fisher PB, Sarkar D. Abstract 2628: The multifunctional protein staphylococcal nuclease domain containing-1 (SND1) promotes migration and invasion of hepatocellular carcinoma (HCC) cells by modulating angiotensin II type 1 receptor (AT1R) and transforming growth factor-β (TGF-β) s Cancer Research. 73: 2628-2628. DOI: 10.1158/1538-7445.Am2013-2628  0.362
2012 Das SK, Sarkar S, Dash R, Dent P, Wang XY, Sarkar D, Fisher PB. Chapter One---Cancer terminator viruses and approaches for enhancing therapeutic outcomes. Advances in Cancer Research. 115: 1-38. PMID 23021240 DOI: 10.1016/B978-0-12-398342-8.00001-X  0.36
2012 Booth L, Cruickshanks N, Ridder T, Chen CS, Grant S, Dent P. OSU-03012 interacts with lapatinib to kill brain cancer cells. Cancer Biology & Therapy. 13: 1501-11. PMID 22990204 DOI: 10.4161/Cbt.22275  0.568
2012 Cruickshanks N, Tang Y, Booth L, Hamed H, Grant S, Dent P. Lapatinib and obatoclax kill breast cancer cells through reactive oxygen species-dependent endoplasmic reticulum stress. Molecular Pharmacology. 82: 1217-29. PMID 22989520 DOI: 10.1124/Mol.112.081539  0.763
2012 Yaseen A, Chen S, Hock S, Rosato R, Dent P, Dai Y, Grant S. Resveratrol sensitizes acute myelogenous leukemia cells to histone deacetylase inhibitors through reactive oxygen species-mediated activation of the extrinsic apoptotic pathway. Molecular Pharmacology. 82: 1030-41. PMID 22923501 DOI: 10.1124/Mol.112.079624  0.494
2012 Chen S, Dai Y, Pei XY, Myers J, Wang L, Kramer LB, Garnett M, Schwartz DM, Su F, Simmons GL, Richey JD, Larsen DG, Dent P, Orlowski RZ, Grant S. CDK inhibitors upregulate BH3-only proteins to sensitize human myeloma cells to BH3 mimetic therapies. Cancer Research. 72: 4225-37. PMID 22693249 DOI: 10.1158/0008-5472.Can-12-1118  0.524
2012 Bareford MD, Hamed HA, Allegood J, Cruickshanks N, Poklepovic A, Park MA, Ogretmen B, Spiegel S, Grant S, Dent P. Sorafenib and pemetrexed toxicity in cancer cells is mediated via SRC-ERK signaling. Cancer Biology & Therapy. 13: 793-803. PMID 22673740 DOI: 10.4161/Cbt.20562  0.85
2012 Tang Y, Hamed HA, Poklepovic A, Dai Y, Grant S, Dent P. Poly(ADP-ribose) polymerase 1 modulates the lethality of CHK1 inhibitors in mammary tumors. Molecular Pharmacology. 82: 322-32. PMID 22596349 DOI: 10.1124/Mol.112.078907  0.754
2012 Emdad L, Dent P, Sarkar D, Fisher PB. Future approaches for the therapy of malignant glioma: targeting genes mediating invasion. Future Oncology (London, England). 8: 343-6. PMID 22515436 DOI: 10.2217/Fon.12.16  0.42
2012 Dasmahapatra G, Lembersky D, Son MP, Patel H, Peterson D, Attkisson E, Fisher RI, Friedberg JW, Dent P, Grant S. Obatoclax interacts synergistically with the irreversible proteasome inhibitor carfilzomib in GC- and ABC-DLBCL cells in vitro and in vivo. Molecular Cancer Therapeutics. 11: 1122-32. PMID 22411899 DOI: 10.1158/1535-7163.Mct-12-0021  0.556
2012 Tang Y, Yacoub A, Hamed HA, Poklepovic A, Tye G, Grant S, Dent P. Sorafenib and HDAC inhibitors synergize to kill CNS tumor cells. Cancer Biology & Therapy. 13: 567-74. PMID 22406992 DOI: 10.4161/Cbt.19771  0.768
2012 Cruickshanks N, Hamed HA, Bareford MD, Poklepovic A, Fisher PB, Grant S, Dent P. Lapatinib and obatoclax kill tumor cells through blockade of ERBB1/3/4 and through inhibition of BCL-XL and MCL-1. Molecular Pharmacology. 81: 748-58. PMID 22357666 DOI: 10.1124/Mol.112.077586  0.837
2012 Booth L, Cazanave SC, Hamed HA, Yacoub A, Ogretmen B, Chen CS, Grant S, Dent P. OSU-03012 suppresses GRP78/BiP expression that causes PERK-dependent increases in tumor cell killing. Cancer Biology & Therapy. 13: 224-36. PMID 22354011 DOI: 10.4161/Cbt.13.4.18877  0.755
2012 Tang Y, Dai Y, Grant S, Dent P. Enhancing CHK1 inhibitor lethality in glioblastoma. Cancer Biology & Therapy. 13: 379-88. PMID 22313687 DOI: 10.4161/Cbt.19240  0.532
2012 Tang Y, Hamed HA, Cruickshanks N, Fisher PB, Grant S, Dent P. Obatoclax and lapatinib interact to induce toxic autophagy through NOXA. Molecular Pharmacology. 81: 527-40. PMID 22219388 DOI: 10.1124/Mol.111.076851  0.742
2012 Rosato R, Hock S, Dent P, Dai Y, Grant S. LBH-589 (panobinostat) potentiates fludarabine anti-leukemic activity through a JNK- and XIAP-dependent mechanism. Leukemia Research. 36: 491-8. PMID 22074700 DOI: 10.1016/J.Leukres.2011.10.020  0.478
2012 Studer E, Zhou X, Zhao R, Wang Y, Takabe K, Nagahashi M, Pandak WM, Dent P, Spiegel S, Shi R, Xu W, Liu X, Bohdan P, Zhang L, Zhou H, et al. Conjugated bile acids activate the sphingosine-1-phosphate receptor 2 in primary rodent hepatocytes. Hepatology (Baltimore, Md.). 55: 267-76. PMID 21932398 DOI: 10.1002/Hep.24681  0.394
2012 Azab B, Dash R, Das SK, Bhutia SK, Shen XN, Quinn BA, Sarkar S, Wang XY, Hedvat M, Dmitriev IP, Curiel DT, Grant S, Dent P, Reed JC, Pellecchia M, et al. Enhanced delivery of mda-7/IL-24 using a serotype chimeric adenovirus (Ad.5/3) in combination with the Apogossypol derivative BI-97C1 (Sabutoclax) improves therapeutic efficacy in low CAR colorectal cancer cells. Journal of Cellular Physiology. 227: 2145-53. PMID 21780116 DOI: 10.1002/Jcp.22947  0.381
2012 Bhutia SK, Das SK, Kegelman TP, Azab B, Dash R, Su ZZ, Wang XY, Rizzi F, Bettuzzi S, Lee SG, Dent P, Grant S, Curiel DT, Sarkar D, Fisher PB. mda-7/IL-24 differentially regulates soluble and nuclear clusterin in prostate cancer. Journal of Cellular Physiology. 227: 1805-13. PMID 21732348 DOI: 10.1002/Jcp.22904  0.442
2012 Azab B, Dash R, Das S, Bhutia S, Shen X, Quinn B, Dasgupta S, Dent P, Dmitriev I, Wang X, Curiel D, Grant S, Pellecchia M, Reed J, Sarkar D, et al. Abstract 61: A new serotype chimera Cancer Terminator Virus (Ad.5/3-CTV) expands the efficiency and specificity of prostate cancer gene transfer and therapy Cancer Research. 72: 61-61. DOI: 10.1158/1538-7445.Am2012-61  0.415
2011 Senkal CE, Ponnusamy S, Manevich Y, Meyers-Needham M, Saddoughi SA, Mukhopadyay A, Dent P, Bielawski J, Ogretmen B. Alteration of ceramide synthase 6/C16-ceramide induces activating transcription factor 6-mediated endoplasmic reticulum (ER) stress and apoptosis via perturbation of cellular Ca2+ and ER/Golgi membrane network. The Journal of Biological Chemistry. 286: 42446-58. PMID 22013072 DOI: 10.1074/Jbc.M111.287383  0.435
2011 Pei XY, Dai Y, Youssefian LE, Chen S, Bodie WW, Takabatake Y, Felthousen J, Almenara JA, Kramer LB, Dent P, Grant S. Cytokinetically quiescent (G0/G1) human multiple myeloma cells are susceptible to simultaneous inhibition of Chk1 and MEK1/2. Blood. 118: 5189-200. PMID 21911831 DOI: 10.1182/Blood-2011-02-339432  0.412
2011 Quinn BA, Dash R, Azab B, Sarkar S, Das SK, Kumar S, Oyesanya RA, Dasgupta S, Dent P, Grant S, Rahmani M, Curiel DT, Dmitriev I, Hedvat M, Wei J, et al. Targeting Mcl-1 for the therapy of cancer. Expert Opinion On Investigational Drugs. 20: 1397-411. PMID 21851287 DOI: 10.1517/13543784.2011.609167  0.406
2011 Dai Y, Chen S, Wang L, Pei XY, Funk VL, Kramer LB, Dent P, Grant S. Disruption of IkappaB kinase (IKK)-mediated RelA serine 536 phosphorylation sensitizes human multiple myeloma cells to histone deacetylase (HDAC) inhibitors. The Journal of Biological Chemistry. 286: 34036-50. PMID 21816815 DOI: 10.1074/Jbc.M111.284216  0.444
2011 Bareford MD, Hamed HA, Tang Y, Cruickshanks N, Burow ME, Fisher PB, Moran RG, Nephew KP, Grant S, Dent P. Sorafenib enhances pemetrexed cytotoxicity through an autophagy-dependent mechanism in cancer cells. Autophagy. 7: 1261-2. PMID 21814046 DOI: 10.4161/Auto.7.10.17029  0.838
2011 Dasmahapatra G, Lembersky D, Son MP, Attkisson E, Dent P, Fisher RI, Friedberg JW, Grant S. Carfilzomib interacts synergistically with histone deacetylase inhibitors in mantle cell lymphoma cells in vitro and in vivo. Molecular Cancer Therapeutics. 10: 1686-97. PMID 21750224 DOI: 10.1158/1535-7163.Mct-10-1108  0.523
2011 Mitchell C, Hamed HA, Cruickshanks N, Tang Y, Bareford MD, Hubbard N, Tye G, Yacoub A, Dai Y, Grant S, Dent P. Simultaneous exposure of transformed cells to SRC family inhibitors and CHK1 inhibitors causes cell death. Cancer Biology & Therapy. 12: 215-28. PMID 21642769 DOI: 10.4161/Cbt.12.3.16218  0.833
2011 Bareford MD, Park MA, Yacoub A, Hamed HA, Tang Y, Cruickshanks N, Eulitt P, Hubbard N, Tye G, Burow ME, Fisher PB, Moran RG, Nephew KP, Grant S, Dent P. Sorafenib enhances pemetrexed cytotoxicity through an autophagy-dependent mechanism in cancer cells. Cancer Research. 71: 4955-67. PMID 21622715 DOI: 10.1158/0008-5472.Can-11-0898  0.841
2011 Bhutia SK, Das SK, Azab B, Dash R, Su ZZ, Lee SG, Dent P, Curiel DT, Sarkar D, Fisher PB. Autophagy switches to apoptosis in prostate cancer cells infected with melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24). Autophagy. 7: 1076-7. PMID 21610321 DOI: 10.4161/Auto.7.9.16163  0.424
2011 Dash R, Azab B, Quinn BA, Shen X, Wang XY, Das SK, Rahmani M, Wei J, Hedvat M, Dent P, Dmitriev IP, Curiel DT, Grant S, Wu B, Stebbins JL, et al. Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24-mediated toxicity. Proceedings of the National Academy of Sciences of the United States of America. 108: 8785-90. PMID 21555592 DOI: 10.1073/Pnas.1100769108  0.433
2011 Dent P, Tang Y, Yacoub A, Dai Y, Fisher PB, Grant S. CHK1 inhibitors in combination chemotherapy: thinking beyond the cell cycle. Molecular Interventions. 11: 133-40. PMID 21540473 DOI: 10.1124/Mi.11.2.11  0.508
2011 Dai Y, Chen S, Wang L, Pei XY, Kramer LB, Dent P, Grant S. Bortezomib interacts synergistically with belinostat in human acute myeloid leukaemia and acute lymphoblastic leukaemia cells in association with perturbations in NF-κB and Bim. British Journal of Haematology. 153: 222-35. PMID 21375523 DOI: 10.1111/J.1365-2141.2011.08591.X  0.465
2011 Dai Y, Chen S, Shah R, Pei XY, Wang L, Almenara JA, Kramer LB, Dent P, Grant S. Disruption of Src function potentiates Chk1-inhibitor-induced apoptosis in human multiple myeloma cells in vitro and in vivo. Blood. 117: 1947-57. PMID 21148814 DOI: 10.1182/Blood-2010-06-291146  0.532
2011 Rhodes LV, Short SP, Neel NF, Salvo VA, Zhu Y, Elliott S, Wei Y, Yu D, Sun M, Muir SE, Fonseca JP, Bratton MR, Segar C, Tilghman SL, Sobolik-Delmaire T, ... ... Dent P, et al. Cytokine receptor CXCR4 mediates estrogen-independent tumorigenesis, metastasis, and resistance to endocrine therapy in human breast cancer. Cancer Research. 71: 603-13. PMID 21123450 DOI: 10.1158/0008-5472.Can-10-3185  0.409
2011 Park MA, Hamed HA, Mitchell C, Cruickshanks N, Dash R, Allegood J, Dmitriev IP, Tye G, Ogretmen B, Spiegel S, Yacoub A, Grant S, Curiel DT, Fisher PB, Dent P. A serotype 5/3 adenovirus expressing MDA-7/IL-24 infects renal carcinoma cells and promotes toxicity of agents that increase ROS and ceramide levels. Molecular Pharmacology. 79: 368-80. PMID 21119025 DOI: 10.1124/Mol.110.069484  0.787
2011 Lépine S, Allegood JC, Park M, Dent P, Milstien S, Spiegel S. Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagy. Cell Death and Differentiation. 18: 350-61. PMID 20798685 DOI: 10.1038/Cdd.2010.104  0.407
2011 Bareford MD, Hamed HA, Park M, Grant S, Fisher P, Dent P. Abstract 5390: A serotype 5/3 adenovirus expressing MDA-7/IL-24 infects renal carcinoma cells and promotes toxicity of agents that increase ROS and ceramide levels Cancer Research. 71: 5390-5390. DOI: 10.1158/1538-7445.Am2011-5390  0.823
2011 Hamed HA, Mitchell C, Dent P, Yacoub A, Tye G, Bareford MD. Abstract 5383: Inhibition of MCL-1 in mammary and CNS tumor cells promotes cell deathin vitroandin vivo Cancer Research. 71: 5383-5383. DOI: 10.1158/1538-7445.Am2011-5383  0.826
2011 Pei X, Dai Y, Youssefian LE, Chen S, Bodie W, Takabatake Y, Almenara G, Kramer L, Dent P, Grant S. Abstract 5367: Simultaneous inhibition of Chk1 and MEK1/2 targets non-proliferating multiple myeloma cells Cancer Research. 71: 5367-5367. DOI: 10.1158/1538-7445.Am2011-5367  0.362
2011 Dasmahapatra GP, Lembersky D, Friedberg JW, Fisher RI, Dent P, Grant S. Abstract 5366: The small molecule Bcl-2 antagonist obatoclax interacts synergistically with the irreversible proteasome inhibitor carfilzomib in GC and ABC- sub types of DLBCL cells bothin vitroandin vivo Cancer Research. 71: 5366-5366. DOI: 10.1158/1538-7445.Am2011-5366  0.564
2010 Eulitt PJ, Park MA, Hossein H, Cruikshanks N, Yang C, Dmitriev IP, Yacoub A, Curiel DT, Fisher PB, Dent P. Enhancing mda-7/IL-24 therapy in renal carcinoma cells by inhibiting multiple protective signaling pathways using sorafenib and by Ad.5/3 gene delivery. Cancer Biology & Therapy. 10: 1290-305. PMID 20948318 DOI: 10.4161/Cbt.10.12.13497  0.473
2010 Dash R, Bhutia SK, Azab B, Su ZZ, Quinn BA, Kegelmen TP, Das SK, Kim K, Lee SG, Park MA, Yacoub A, Rahmani M, Emdad L, Dmitriev IP, Wang XY, ... ... Dent P, et al. mda-7/IL-24: a unique member of the IL-10 gene family promoting cancer-targeted toxicity. Cytokine & Growth Factor Reviews. 21: 381-91. PMID 20926331 DOI: 10.1016/J.Cytogfr.2010.08.004  0.428
2010 Das A, Durrant D, Mitchell C, Mayton E, Hoke NN, Salloum FN, Park MA, Qureshi I, Lee R, Dent P, Kukreja RC. Sildenafil increases chemotherapeutic efficacy of doxorubicin in prostate cancer and ameliorates cardiac dysfunction. Proceedings of the National Academy of Sciences of the United States of America. 107: 18202-7. PMID 20884855 DOI: 10.1073/Pnas.1006965107  0.633
2010 Rahmani M, Mayo M, Dash R, Sokhi UK, Dmitriev IP, Sarkar D, Dent P, Curiel DT, Fisher PB, Grant S. Melanoma differentiation associated gene-7/interleukin-24 potently induces apoptosis in human myeloid leukemia cells through a process regulated by endoplasmic reticulum stress. Molecular Pharmacology. 78: 1096-104. PMID 20858700 DOI: 10.1124/Mol.110.068007  0.432
2010 Mitchell C, Yacoub A, Hossein H, Martin AP, Bareford MD, Eulitt P, Yang C, Nephew KP, Dent P. Inhibition of MCL-1 in breast cancer cells promotes cell death in vitro and in vivo. Cancer Biology & Therapy. 10: 903-17. PMID 20855960 DOI: 10.4161/Cbt.10.9.13273  0.851
2010 Jia W, Loria RM, Park MA, Yacoub A, Dent P, Graf MR. The neuro-steroid, 5-androstene 3β,17α diol; induces endoplasmic reticulum stress and autophagy through PERK/eIF2α signaling in malignant glioma cells and transformed fibroblasts. The International Journal of Biochemistry & Cell Biology. 42: 2019-29. PMID 20851775 DOI: 10.1016/J.Biocel.2010.09.003  0.453
2010 Murakami M, Ugai H, Wang M, Belousova N, Dent P, Fisher PB, Glasgow JN, Everts M, Curiel DT. An adenoviral vector expressing human adenovirus 5 and 3 fiber proteins for targeting heterogeneous cell populations. Virology. 407: 196-205. PMID 20828776 DOI: 10.1016/J.Virol.2010.08.010  0.332
2010 Dent P, Yacoub A, Hamed HA, Park MA, Dash R, Bhutia SK, Sarkar D, Wang XY, Gupta P, Emdad L, Lebedeva IV, Sauane M, Su ZZ, Rahmani M, Broaddus WC, et al. The development of MDA-7/IL-24 as a cancer therapeutic. Pharmacology & Therapeutics. 128: 375-84. PMID 20732354 DOI: 10.1016/J.Pharmthera.2010.08.001  0.701
2010 Dai Y, Guzman ML, Chen S, Wang L, Yeung SK, Pei XY, Dent P, Jordan CT, Grant S. The NF (Nuclear factor)-κB inhibitor parthenolide interacts with histone deacetylase inhibitors to induce MKK7/JNK1-dependent apoptosis in human acute myeloid leukaemia cells. British Journal of Haematology. 151: 70-83. PMID 20701602 DOI: 10.1111/J.1365-2141.2010.08319.X  0.542
2010 Mitchell C, Park M, Eulitt P, Yang C, Yacoub A, Dent P. Poly(ADP-ribose) polymerase 1 modulates the lethality of CHK1 inhibitors in carcinoma cells. Molecular Pharmacology. 78: 909-17. PMID 20696794 DOI: 10.1124/Mol.110.067199  0.706
2010 Park MA, Reinehr R, Häussinger D, Voelkel-Johnson C, Ogretmen B, Yacoub A, Grant S, Dent P. Sorafenib activates CD95 and promotes autophagy and cell death via Src family kinases in gastrointestinal tumor cells. Molecular Cancer Therapeutics. 9: 2220-31. PMID 20682655 DOI: 10.1158/1535-7163.Mct-10-0274  0.39
2010 Park MA, Mitchell C, Zhang G, Yacoub A, Allegood J, Häussinger D, Reinehr R, Larner A, Spiegel S, Fisher PB, Voelkel-Johnson C, Ogretmen B, Grant S, Dent P. Vorinostat and sorafenib increase CD95 activation in gastrointestinal tumor cells through a Ca(2+)-de novo ceramide-PP2A-reactive oxygen species-dependent signaling pathway. Cancer Research. 70: 6313-24. PMID 20631069 DOI: 10.1158/0008-5472.Can-10-0999  0.652
2010 Dent P, Yacoub A, Hamed HA, Park MA, Dash R, Bhutia SK, Sarkar D, Gupta P, Emdad L, Lebedeva IV, Sauane M, Su ZZ, Rahmani M, Broaddus WC, Young HF, et al. MDA-7/IL-24 as a cancer therapeutic: from bench to bedside. Anti-Cancer Drugs. 21: 725-31. PMID 20613485 DOI: 10.1097/Cad.0B013E32833Cfbe1  0.691
2010 Dash R, Richards JE, Su ZZ, Bhutia SK, Azab B, Rahmani M, Dasmahapatra G, Yacoub A, Dent P, Dmitriev IP, Curiel DT, Grant S, Pellecchia M, Reed JC, Sarkar D, et al. Mechanism by which Mcl-1 regulates cancer-specific apoptosis triggered by mda-7/IL-24, an IL-10-related cytokine. Cancer Research. 70: 5034-45. PMID 20501829 DOI: 10.1158/0008-5472.Can-10-0563  0.413
2010 Walker T, Mitchell C, Park MA, Yacoub A, Rahmani M, Häussinger D, Reinehr R, Voelkel-Johnson C, Fisher PB, Grant S, Dent P. 17-allylamino-17-demethoxygeldanamycin and MEK1/2 inhibitors kill GI tumor cells via Ca2+-dependent suppression of GRP78/BiP and induction of ceramide and reactive oxygen species. Molecular Cancer Therapeutics. 9: 1378-95. PMID 20442308 DOI: 10.1158/1535-7163.Mct-09-1131  0.798
2010 Bhutia SK, Dash R, Das SK, Azab B, Su ZZ, Lee SG, Grant S, Yacoub A, Dent P, Curiel DT, Sarkar D, Fisher PB. Mechanism of autophagy to apoptosis switch triggered in prostate cancer cells by antitumor cytokine melanoma differentiation-associated gene 7/interleukin-24. Cancer Research. 70: 3667-76. PMID 20406981 DOI: 10.1158/0008-5472.Can-09-3647  0.451
2010 Cao R, Cronk ZX, Zha W, Sun L, Wang X, Fang Y, Studer E, Zhou H, Pandak WM, Dent P, Gil G, Hylemon PB. Bile acids regulate hepatic gluconeogenic genes and farnesoid X receptor via G(alpha)i-protein-coupled receptors and the AKT pathway. Journal of Lipid Research. 51: 2234-44. PMID 20305288 DOI: 10.1194/Jlr.M004929  0.361
2010 Dasmahapatra G, Lembersky D, Kramer L, Fisher RI, Friedberg J, Dent P, Grant S. The pan-HDAC inhibitor vorinostat potentiates the activity of the proteasome inhibitor carfilzomib in human DLBCL cells in vitro and in vivo. Blood. 115: 4478-87. PMID 20233973 DOI: 10.1182/Blood-2009-12-257261  0.55
2010 Hamed HA, Yacoub A, Park MA, Eulitt PJ, Dash R, Sarkar D, Dmitriev IP, Lesniak MS, Shah K, Grant S, Curiel DT, Fisher PB, Dent P. Inhibition of multiple protective signaling pathways and Ad.5/3 delivery enhances mda-7/IL-24 therapy of malignant glioma. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 1130-42. PMID 20179672 DOI: 10.1038/Mt.2010.29  0.737
2010 Nguyen TK, Jordan N, Friedberg J, Fisher RI, Dent P, Grant S. Inhibition of MEK/ERK1/2 sensitizes lymphoma cells to sorafenib-induced apoptosis. Leukemia Research. 34: 379-86. PMID 20117835 DOI: 10.1016/J.Leukres.2009.07.013  0.516
2010 Hamed HA, Yacoub A, Park MA, Eulitt P, Sarkar D, Dimitrie IP, Chen CS, Grant S, Curiel DT, Fisher PB, Dent P. OSU-03012 enhances Ad.7-induced GBM cell killing via ER stress and autophagy and by decreasing expression of mitochondrial protective proteins. Cancer Biology & Therapy. 9: 526-36. PMID 20107314 DOI: 10.4161/Cbt.9.7.11116  0.752
2010 Yacoub A, Hamed HA, Allegood J, Mitchell C, Spiegel S, Lesniak MS, Ogretmen B, Dash R, Sarkar D, Broaddus WC, Grant S, Curiel DT, Fisher PB, Dent P. PERK-dependent regulation of ceramide synthase 6 and thioredoxin play a key role in mda-7/IL-24-induced killing of primary human glioblastoma multiforme cells. Cancer Research. 70: 1120-9. PMID 20103619 DOI: 10.1158/0008-5472.Can-09-4043  0.804
2010 Rosato RR, Kolla SS, Hock SK, Almenara JA, Patel A, Amin S, Atadja P, Fisher PB, Dent P, Grant S. Histone deacetylase inhibitors activate NF-kappaB in human leukemia cells through an ATM/NEMO-related pathway. The Journal of Biological Chemistry. 285: 10064-77. PMID 20065354 DOI: 10.1074/Jbc.M109.095208  0.419
2010 Emdad L, Sarkar D, Lee SG, Su ZZ, Yoo BK, Dash R, Yacoub A, Fuller CE, Shah K, Dent P, Bruce JN, Fisher PB. Astrocyte elevated gene-1: a novel target for human glioma therapy. Molecular Cancer Therapeutics. 9: 79-88. PMID 20053777 DOI: 10.1158/1535-7163.Mct-09-0752  0.415
2010 Sauane M, Su ZZ, Dash R, Liu X, Norris JS, Sarkar D, Lee SG, Allegood JC, Dent P, Spiegel S, Fisher PB. Ceramide plays a prominent role in MDA-7/IL-24-induced cancer-specific apoptosis. Journal of Cellular Physiology. 222: 546-55. PMID 19937735 DOI: 10.1002/Jcp.21969  0.467
2010 Yacoub A, Liu R, Park MA, Hamed HA, Dash R, Schramm DN, Sarkar D, Dimitriev IP, Bell JK, Grant S, Farrell NP, Curiel DT, Fisher PB, Dent P. Cisplatin enhances protein kinase R-like endoplasmic reticulum kinase- and CD95-dependent melanoma differentiation-associated gene-7/interleukin-24-induced killing in ovarian carcinoma cells. Molecular Pharmacology. 77: 298-310. PMID 19910452 DOI: 10.1124/Mol.109.061820  0.728
2010 Murakami M, Ugai H, Belousova N, Pereboev A, Dent P, Fisher PB, Everts M, Curiel DT. Chimeric adenoviral vectors incorporating a fiber of human adenovirus 3 efficiently mediate gene transfer into prostate cancer cells. The Prostate. 70: 362-76. PMID 19902467 DOI: 10.1002/Pros.21070  0.335
2010 Greco A, Di Benedetto A, Howard CM, Kelly S, Nande R, Dementieva Y, Miranda M, Brunetti A, Salvatore M, Claudio L, Sarkar D, Dent P, Curiel DT, Fisher PB, Claudio PP. Eradication of therapy-resistant human prostate tumors using an ultrasound-guided site-specific cancer terminator virus delivery approach. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 295-306. PMID 19888195 DOI: 10.1038/Mt.2009.252  0.408
2010 Dasmahapatra G, Lembersky D, Friedberg JW, Fisher RI, Dent P, Grant S. Histone Deacetylase Inhibitors Potentiate the Lethality of the Irreversible Proteasome Inhibitor Carfilzomib In Mantle Cell Lymphoma Cells In Vitro and In Vivo Blood. 116: 3938-3938. DOI: 10.1182/Blood.V116.21.3938.3938  0.562
2010 Dai Y, Chen S, Wang L, Pei X, Kramer L, Dent P, Grant S. Bortezomib Interacts Synergistically with Belinostat to Induce Apoptosis In Human Acute Myeloid and Lymphoid Leukemia Cells Blood. 116: 3266-3266. DOI: 10.1182/Blood.V116.21.3266.3266  0.507
2010 Dai Y, Chen S, Wang L, Myers J, Thompson N, Pei X, Orlowski R, Dent P, Grant S. Abstract 667: Mechanisms underlying synergistic interactions between the CDK inhibitor flavopiridol (Alvocidib) and the BH3 mimetic GX15-070 (Obatoclax) in human multiple myeloma cells Cancer Research. 70: 667-667. DOI: 10.1158/1538-7445.Am10-667  0.564
2010 Rahmani M, Mayo M, Dent P, Grant S. Abstract 4523: Inhibition of Bcl-2 antiapoptotic members by obatoclax dramatically potentiates sorafenib-induced apoptosis in human myeloid leukemia cells through a Bim-dependent process Cancer Research. 70: 4523-4523. DOI: 10.1158/1538-7445.Am10-4523  0.46
2010 Rosato RR, Kolla SS, Hock SK, Almenara JA, Atadja P, Dent P, Grant S. Abstract 3652: HDAC inhibitors activate NF-κB in human leukemia cells through an ATM/NEMO-dependent DNA Damage-related pathway Cancer Research. 70: 3652-3652. DOI: 10.1158/1538-7445.Am10-3652  0.418
2010 Rahmani M, Mayo M, Dash R, Dent P, Fisher PB, Grant S. Abstract 1511: mda-7/IL-24 potently induces apoptosis in human leukemia cells through a process involving induction of ER stress Cancer Research. 70: 1511-1511. DOI: 10.1158/1538-7445.Am10-1511  0.446
2010 Bhutia SK, Dash R, Azab B, Das S, Su Z, Lee S, Grant S, Dent P, Curiel DT, Sarkar D, Fisher PB. Abstract 1038: Defining the mechanism by which melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24)-induced autophagy switches to apoptosis in prostate cancer cells Cancer Research. 70: 1038-1038. DOI: 10.1158/1538-7445.Am10-1038  0.459
2010 Sisler JD, Szelag M, Potla R, Zhang Q, Szczepanek K, Derecka M, Wegrzyn J, Dulak J, Hamed H, Cichy J, Chen X, Baker DP, Dent P, Feldman GM, Shadel G, et al. PS1-58 The role of STAT1 in regulation of mitochondrial gene expression Cytokine. 52: 29-29. DOI: 10.1016/J.Cyto.2010.07.130  0.636
2009 Dent P, Curiel DT, Grant S, Fisher PB. Minting a new class of polo-like-kinase inhibitors. Cancer Biology & Therapy. 8: 2384-5. PMID 20009506 DOI: 10.4161/Cbt.8.24.10389  0.348
2009 Martin AP, Mitchell C, Rahmani M, Nephew KP, Grant S, Dent P. Inhibition of MCL-1 enhances lapatinib toxicity and overcomes lapatinib resistance via BAK-dependent autophagy. Cancer Biology & Therapy. 8: 2084-96. PMID 19823038 DOI: 10.4161/Cbt.8.21.9895  0.787
2009 Rahmani M, Anderson A, Habibi JR, Crabtree TR, Mayo M, Harada H, Ferreira-Gonzalez A, Dent P, Grant S. The BH3-only protein Bim plays a critical role in leukemia cell death triggered by concomitant inhibition of the PI3K/Akt and MEK/ERK1/2 pathways. Blood. 114: 4507-16. PMID 19773546 DOI: 10.1182/Blood-2008-09-177881  0.516
2009 Kapitonov D, Allegood JC, Mitchell C, Hait NC, Almenara JA, Adams JK, Zipkin RE, Dent P, Kordula T, Milstien S, Spiegel S. Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts. Cancer Research. 69: 6915-23. PMID 19723667 DOI: 10.1158/0008-5472.Can-09-0664  0.716
2009 Martin AP, Park MA, Mitchell C, Walker T, Rahmani M, Thorburn A, Häussinger D, Reinehr R, Grant S, Dent P. BCL-2 family inhibitors enhance histone deacetylase inhibitor and sorafenib lethality via autophagy and overcome blockade of the extrinsic pathway to facilitate killing. Molecular Pharmacology. 76: 327-41. PMID 19483105 DOI: 10.1124/Mol.109.056309  0.83
2009 Walker T, Mitchell C, Park MA, Yacoub A, Graf M, Rahmani M, Houghton PJ, Voelkel-Johnson C, Grant S, Dent P. Sorafenib and vorinostat kill colon cancer cells by CD95-dependent and -independent mechanisms. Molecular Pharmacology. 76: 342-55. PMID 19483104 DOI: 10.1124/Mol.109.056523  0.789
2009 Chen L, Jarujaron S, Wu X, Sun L, Zha W, Liang G, Wang X, Gurley EC, Studer EJ, Hylemon PB, Pandak WM, Zhang L, Wang G, Li X, Dent P, et al. HIV protease inhibitor lopinavir-induced TNF-alpha and IL-6 expression is coupled to the unfolded protein response and ERK signaling pathways in macrophages. Biochemical Pharmacology. 78: 70-7. PMID 19447225 DOI: 10.1016/J.Bcp.2009.03.022  0.369
2009 Park MA, Walker T, Martin AP, Allegood J, Vozhilla N, Emdad L, Sarkar D, Rahmani M, Graf M, Yacoub A, Koumenis C, Spiegel S, Curiel DT, Voelkel-Johnson C, Grant S, ... ... Dent P, et al. MDA-7/IL-24-induced cell killing in malignant renal carcinoma cells occurs by a ceramide/CD95/PERK-dependent mechanism. Molecular Cancer Therapeutics. 8: 1280-91. PMID 19417161 DOI: 10.1158/1535-7163.Mct-09-0073  0.797
2009 Dent P, Curiel DT, Fisher PB, Grant S. Synergistic combinations of signaling pathway inhibitors: mechanisms for improved cancer therapy. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 12: 65-73. PMID 19395305 DOI: 10.1016/J.Drup.2009.03.001  0.509
2009 Graf MR, Jia W, Johnson RS, Dent P, Mitchell C, Loria RM. Autophagy and the functional roles of Atg5 and beclin-1 in the anti-tumor effects of 3beta androstene 17alpha diol neuro-steroid on malignant glioma cells. The Journal of Steroid Biochemistry and Molecular Biology. 115: 137-45. PMID 19375507 DOI: 10.1016/J.Jsbmb.2009.03.013  0.569
2009 Hylemon PB, Zhou H, Pandak WM, Ren S, Gil G, Dent P. Bile acids as regulatory molecules. Journal of Lipid Research. 50: 1509-20. PMID 19346331 DOI: 10.1194/Jlr.R900007-Jlr200  0.316
2009 Emdad L, Lebedeva IV, Su ZZ, Gupta P, Sauane M, Dash R, Grant S, Dent P, Curiel DT, Sarkar D, Fisher PB. Historical perspective and recent insights into our understanding of the molecular and biochemical basis of the antitumor properties of mda-7/IL-24. Cancer Biology & Therapy. 8: 391-400. PMID 19276652 DOI: 10.4161/Cbt.8.5.7581  0.387
2009 Dasmahapatra G, Lembersky D, Rahmani M, Kramer L, Friedberg J, Fisher RI, Dent P, Grant S. Bcl-2 antagonists interact synergistically with bortezomib in DLBCL cells in association with JNK activation and induction of ER stress. Cancer Biology & Therapy. 8: 808-19. PMID 19270531 DOI: 10.4161/Cbt.8.9.8131  0.45
2009 Van Maerken T, Sarkar D, Speleman F, Dent P, Weiss WA, Fisher PB. Adenovirus-mediated hPNPase(old-35) gene transfer as a therapeutic strategy for neuroblastoma. Journal of Cellular Physiology. 219: 707-15. PMID 19202553 DOI: 10.1002/Jcp.21719  0.439
2009 Dent P, Grant S, Fisher PB, Curiel DT. PI3K: A rational target for ovarian cancer therapy? Cancer Biology & Therapy. 8: 27-30. PMID 19127116 DOI: 10.4161/Cbt.8.1.7365  0.354
2009 Ihle NT, Lemos R, Wipf P, Yacoub A, Mitchell C, Siwak D, Mills GB, Dent P, Kirkpatrick DL, Powis G. Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance. Cancer Research. 69: 143-50. PMID 19117997 DOI: 10.1158/0008-5472.Can-07-6656  0.622
2009 Dai Y, Chen S, Pei X, Ramakrishnan V, Wang M, Orlowski R, Dent P, Grant S. Targeting CDK9 Dramatically Potentiates ABT-737-Induced Apoptosis in Human Multiple Myeloma Cells through a Bim-Dependent Mechanism. Blood. 114: 297-297. DOI: 10.1182/Blood.V114.22.297.297  0.529
2009 Dasmahapatra G, Lembersky D, Kramer L, Friedberg JW, Fisher RI, Dent P, Grant S. The Novel Proteasome Inhibitor Carfilzomib Interacts Synergistically with HDAC Inhibitors in ABC- and GC-DLBCL Cells Both in Vitro and In Vivo through Mechanisms Involving JNK Activation, NF-κB Inactivation, and DNA Damage.. Blood. 114: 1688-1688. DOI: 10.1182/Blood.V114.22.1688.1688  0.556
2009 Szelag M, Potla R, Sisler J, Hamed H, Dent P, Larner AC. STAT1 Expression represses the expression of mitochondrial encoded RNAS Cytokine. 48: 123-124. DOI: 10.1016/J.Cyto.2009.07.522  0.626
2008 Rosato RR, Almenara JA, Maggio SC, Coe S, Atadja P, Dent P, Grant S. Role of histone deacetylase inhibitor-induced reactive oxygen species and DNA damage in LAQ-824/fludarabine antileukemic interactions Molecular Cancer Therapeutics. 7: 3285-3297. PMID 18852132 DOI: 10.1158/1535-7163.Mct-08-0385  0.375
2008 Singhal J, Singhal SS, Yadav S, Suzuki S, Warnke MM, Yacoub A, Dent P, Bae S, Sharma R, Awasthi YC, Armstrong DW, Awasthi S. RLIP76 in defense of radiation poisoning. International Journal of Radiation Oncology, Biology, Physics. 72: 553-61. PMID 18793957 DOI: 10.1016/J.Ijrobp.2008.06.1497  0.366
2008 Park MA, Zhang G, Mitchell C, Rahmani M, Hamed H, Hagan MP, Yacoub A, Curiel DT, Fisher PB, Grant S, Dent P. Mitogen-activated protein kinase kinase 1/2 inhibitors and 17-allylamino-17-demethoxygeldanamycin synergize to kill human gastrointestinal tumor cells in vitro via suppression of c-FLIP-s levels and activation of CD95. Molecular Cancer Therapeutics. 7: 2633-48. PMID 18790746 DOI: 10.1158/1535-7163.Mct-08-0400  0.827
2008 Park MA, Zhang G, Martin AP, Hamed H, Mitchell C, Hylemon PB, Graf M, Rahmani M, Ryan K, Liu X, Spiegel S, Norris J, Fisher PB, Grant S, Dent P. Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation. Cancer Biology & Therapy. 7: 1648-62. PMID 18787411 DOI: 10.4161/Cbt.7.10.6623  0.797
2008 Lebedeva IV, Su ZZ, Vozhilla N, Chatman L, Sarkar D, Dent P, Athar M, Fisher PB. Mechanism of in vitro pancreatic cancer cell growth inhibition by melanoma differentiation-associated gene-7/interleukin-24 and perillyl alcohol. Cancer Research. 68: 7439-47. PMID 18768668 DOI: 10.1158/0008-5472.Can-08-0072  0.438
2008 Zhang G, Park MA, Mitchell C, Hamed H, Rahmani M, Martin AP, Curiel DT, Yacoub A, Graf M, Lee R, Roberts JD, Fisher PB, Grant S, Dent P. Vorinostat and sorafenib synergistically kill tumor cells via FLIP suppression and CD95 activation. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 5385-99. PMID 18765530 DOI: 10.1158/1078-0432.Ccr-08-0469  0.816
2008 Paul CP, Everts M, Glasgow JN, Dent P, Fisher PB, Ulasov IV, Lesniak MS, Stoff-Khalili MA, Roth JC, Preuss MA, Dirven CM, Lamfers ML, Siegal GP, Zhu ZB, Curiel DT. Characterization of infectivity of knob-modified adenoviral vectors in glioma. Cancer Biology & Therapy. 7: 786-93. PMID 18756624 DOI: 10.4161/Cbt.7.5.5421  0.368
2008 Park MA, Zhang G, Norris J, Hylemon PB, Fisher PB, Grant S, Dent P. Regulation of autophagy by ceramide-CD95-PERK signaling Autophagy. 4: 929-931. PMID 18719356 DOI: 10.4161/Auto.6732  0.485
2008 Dent P, Yacoub A, Park M, Sarkar D, Shah K, Curiel DT, Grant S, Fisher PB. Searching for a cure: gene therapy for glioblastoma. Cancer Biology & Therapy. 7: 1335-40. PMID 18708757 DOI: 10.4161/Cbt.7.9.6408  0.452
2008 Lebedeva IV, Su ZZ, Vozhilla N, Chatman L, Sarkar D, Dent P, Athar M, Fisher PB. Chemoprevention by perillyl alcohol coupled with viral gene therapy reduces pancreatic cancer pathogenesis. Molecular Cancer Therapeutics. 7: 2042-50. PMID 18645014 DOI: 10.1158/1535-7163.Mct-08-0245  0.391
2008 Dai Y, Chen S, Pei XY, Almenara JA, Kramer LB, Venditti CA, Dent P, Grant S. Interruption of the Ras/MEK/ERK signaling cascade enhances Chk1 inhibitor-induced DNA damage in vitro and in vivo in human multiple myeloma cells. Blood. 112: 2439-49. PMID 18614762 DOI: 10.1182/Blood-2008-05-159392  0.463
2008 Zhang G, Park MA, Mitchell C, Walker T, Hamed H, Studer E, Graf M, Rahmani M, Gupta S, Hylemon PB, Fisher PB, Grant S, Dent P. Multiple cyclin kinase inhibitors promote bile acid-induced apoptosis and autophagy in primary hepatocytes via p53-CD95-dependent signaling. The Journal of Biological Chemistry. 283: 24343-58. PMID 18614532 DOI: 10.1074/Jbc.M803444200  0.836
2008 Sauane M, Su ZZ, Gupta P, Lebedeva IV, Dent P, Sarkar D, Fisher PB. Autocrine regulation of mda-7/IL-24 mediates cancer-specific apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 105: 9763-8. PMID 18599461 DOI: 10.1073/Pnas.0804089105  0.439
2008 Martin AP, Miller A, Emad L, Rahmani M, Walker T, Mitchell C, Hagan MP, Park MA, Yacoub A, Fisher PB, Grant S, Dent P. Lapatinib resistance in HCT116 cells is mediated by elevated MCL-1 expression and decreased BAK activation and not by ERBB receptor kinase mutation. Molecular Pharmacology. 74: 807-22. PMID 18544666 DOI: 10.1124/Mol.108.047365  0.835
2008 Tsuruta Y, Pereboeva L, Breidenbach M, Rein DT, Wang M, Alvarez RD, Siegal GP, Dent P, Fisher PB, Curiel DT. A fiber-modified mesothelin promoter-based conditionally replicating adenovirus for treatment of ovarian cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 3582-8. PMID 18519792 DOI: 10.1158/1078-0432.Ccr-07-5053  0.337
2008 Dai Y, Chen S, Venditti CA, Pei XY, Nguyen TK, Dent P, Grant S. Vorinostat synergistically potentiates MK-0457 lethality in chronic myelogenous leukemia cells sensitive and resistant to imatinib mesylate. Blood. 112: 793-804. PMID 18505786 DOI: 10.1182/Blood-2007-10-116376  0.497
2008 Hamed H, Mitchell C, Park MA, Hanna D, Martin AP, Harrison B, Hawkins W, Curiel DA, Fisher PB, Grant S, Yacoub A, Hagan MP, Dent P. Human chorionic gonadotropin (hCG) interacts with lovastatin and ionizing radiation to modulate prostate cancer cell viability in vivo. Cancer Biology & Therapy. 7: 587-93. PMID 18379195 DOI: 10.4161/Cbt.7.4.5543  0.821
2008 Yacoub A, Hamed H, Emdad L, Dos Santos W, Gupta P, Broaddus WC, Ramakrishnan V, Sarkar D, Shah K, Curiel DT, Grant S, Fisher PB, Dent P. MDA-7/IL-24 plus radiation enhance survival in animals with intracranial primary human GBM tumors. Cancer Biology & Therapy. 7: 917-33. PMID 18376144 DOI: 10.4161/Cbt.7.6.5928  0.732
2008 Oyesanya RA, Lee ZP, Wu J, Chen J, Song Y, Mukherjee A, Dent P, Kordula T, Zhou H, Fang X. Transcriptional and post-transcriptional mechanisms for lysophosphatidic acid-induced cyclooxygenase-2 expression in ovarian cancer cells. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 2639-51. PMID 18362203 DOI: 10.1096/Fj.07-101428  0.398
2008 Hamed H, Hawkins W, Mitchell C, Gilfor D, Zhang G, Pei XY, Dai Y, Hagan MP, Roberts JD, Yacoub A, Grant S, Dent P. Transient exposure of carcinoma cells to RAS/MEK inhibitors and UCN-01 causes cell death in vitro and in vivo. Molecular Cancer Therapeutics. 7: 616-29. PMID 18347148 DOI: 10.1158/1535-7163.Mct-07-2376  0.793
2008 Park MA, Yacoub A, Sarkar D, Emdad L, Rahmani M, Spiegel S, Koumenis C, Graf M, Curiel DT, Grant S, Fisher PB, Dent P. PERK-dependent regulation of MDA-7/IL-24-induced autophagy in primary human glioma cells. Autophagy. 4: 513-5. PMID 18299661 DOI: 10.4161/Auto.5725  0.567
2008 Yacoub A, Gupta P, Park MA, Rhamani M, Hamed H, Hanna D, Zhang G, Sarkar D, Lebedeva IV, Emdad L, Koumenis C, Curiel DT, Grant S, Fisher PB, Dent P. Regulation of GST-MDA-7 toxicity in human glioblastoma cells by ERBB1, ERK1/2, PI3K, and JNK1-3 pathway signaling Molecular Cancer Therapeutics. 7: 314-329. PMID 18281516 DOI: 10.1158/1535-7163.Mct-07-2150  0.763
2008 Yacoub A, Park MA, Gupta P, Rahmani M, Zhang G, Hamed H, Hanna D, Sarkar D, Lebedeva IV, Emdad L, Sauane M, Vozhilla N, Spiegel S, Koumenis C, Graf M, ... ... Dent P, et al. Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells. Molecular Cancer Therapeutics. 7: 297-313. PMID 18281515 DOI: 10.1158/1535-7163.Mct-07-2166  0.779
2008 Sarkar D, Dent P, Curiel DT, Fisher PB. Acquired and innate resistance to the cancer-specific apoptosis-inducing cytokine, mda-7/IL-24: Not insurmountable therapeutic problems Cancer Biology and Therapy. 7: 109-112. PMID 18277093 DOI: 10.4161/Cbt.7.1.5693  0.456
2008 Gupta P, Emdad L, Lebedeva IV, Sarkar D, Dent P, Curiel DT, Settleman J, Fisher PB. Targeted combinatorial therapy of non-small cell lung carcinoma using a GST-fusion protein of full-length or truncated MDA-7/IL-24 with Tarceva. Journal of Cellular Physiology. 215: 827-36. PMID 18270968 DOI: 10.1002/Jcp.21369  0.472
2008 Dai Y, Chen S, Kramer LB, Funk VL, Dent P, Grant S. Interactions between bortezomib and romidepsin and belinostat in chronic lymphocytic leukemia cells. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 549-58. PMID 18223231 DOI: 10.1158/1078-0432.Ccr-07-1934  0.38
2008 Park MA, Curiel DT, Koumenis C, Graf M, Chen CS, Fisher PB, Grant S, Dent P. PERK-dependent regulation of HSP70 expression and the regulation of autophagy. Autophagy. 4: 364-7. PMID 18216498 DOI: 10.4161/Auto.5593  0.47
2008 Park MA, Yacoub A, Rahmani M, Zhang G, Hart L, Hagan MP, Calderwood SK, Sherman MY, Koumenis C, Spiegel S, Chen CS, Graf M, Curiel DT, Fisher PB, Grant S, ... Dent P, et al. OSU-03012 stimulates PKR-like endoplasmic reticulum-dependent increases in 70-kDa heat shock protein expression, attenuating its lethal actions in transformed cells. Molecular Pharmacology. 73: 1168-84. PMID 18182481 DOI: 10.1124/Mol.107.042697  0.486
2008 Sarkar D, Dent P, Curiel DT, Fisher PB. INGN-241: Cancer gene therapy Drugs of the Future. 33: 396-401. DOI: 10.1358/Dof.2008.033.05.1201624  0.468
2008 Hagan M, Yacoub A, Dent P. PARG Release from the Mitochondria Regulates the Duration of ERK-induced PARP1 Activation Following Ionizing Irradiation International Journal of Radiation Oncology Biology Physics. 72. DOI: 10.1016/J.Ijrobp.2008.06.812  0.351
2007 Dent P, Hylemon PB, Grant S, Fisher PB. Approaches for monitoring signal transduction changes in normal and cancer cells Methods in Molecular Biology (Clifton, N.J.). 383: 259-276. PMID 18217691 DOI: 10.1007/978-1-59745-335-6_17  0.368
2007 Mitchell C, Park MA, Zhang G, Yacoub A, Curiel DT, Fisher PB, Roberts JD, Grant S, Dent P. Extrinsic pathway- and cathepsin-dependent induction of mitochondrial dysfunction are essential for synergistic flavopiridol and vorinostat lethality in breast cancer cells. Molecular Cancer Therapeutics. 6: 3101-12. PMID 18065490 DOI: 10.1158/1535-7163.Mct-07-0561  0.723
2007 Emdad L, Lebedeva IV, Su ZZ, Sarkar D, Dent P, Curiel DT, Fisher PB. Melanoma differentiation associated gene-7/interleukin-24 reverses multidrug resistance in human colorectal cancer cells. Molecular Cancer Therapeutics. 6: 2985-94. PMID 18025283 DOI: 10.1158/1535-7163.Mct-07-0399  0.455
2007 Sankala HM, Hait NC, Paugh SW, Shida D, Lépine S, Elmore LW, Dent P, Milstien S, Spiegel S. Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin. Cancer Research. 67: 10466-74. PMID 17974990 DOI: 10.1158/0008-5472.Can-07-2090  0.439
2007 Lebedeva IV, Emdad L, Su ZZ, Gupta P, Sauane M, Sarkar D, Staudt MR, Liu SJ, Taher MM, Xiao R, Barral P, Lee SG, Wang D, Vozhilla N, Park ES, ... ... Dent P, et al. mda-7/IL-24, novel anticancer cytokine: focus on bystander antitumor, radiosensitization and antiangiogenic properties and overview of the phase I clinical experience (Review). International Journal of Oncology. 31: 985-1007. PMID 17912425 DOI: 10.3892/Ijo.31.5.985  0.421
2007 Dasmahapatra G, Yerram N, Dai Y, Dent P, Grant S. Synergistic interactions between vorinostat and sorafenib in chronic myelogenous leukemia cells involve Mcl-1 and p21CIP1 down-regulation Clinical Cancer Research. 13: 4280-4290. PMID 17634558 DOI: 10.1158/1078-0432.Ccr-07-0835  0.537
2007 Rahmani M, Nguyen TK, Dent P, Grant S. The multikinase inhibitor sorafenib induces apoptosis in highly imatinib mesylate-resistant bcr/abl+ human leukemia cells in association with signal transducer and activator of transcription 5 inhibition and myeloid cell leukemia-1 down-regulation. Molecular Pharmacology. 72: 788-95. PMID 17595328 DOI: 10.1124/Mol.106.033308  0.536
2007 Grant S, Dent P. Simultaneous interruption of signal transduction and cell cycle regulatory pathways: Implications for new approaches to the treatment of childhood leukemias Current Drug Targets. 8: 751-759. PMID 17584030 DOI: 10.2174/138945007780830764  0.464
2007 Mitchell C, Kabolizadeh P, Ryan J, Roberts JD, Yacoub A, Curiel DT, Fisher PB, Hagan MP, Farrell NP, Grant S, Dent P. Low-dose BBR3610 toxicity in colon cancer cells is p53-independent and enhanced by inhibition of epidermal growth factor receptor (ERBB1)-phosphatidyl inositol 3 kinase signaling. Molecular Pharmacology. 72: 704-14. PMID 17578896 DOI: 10.1124/Mol.107.038406  0.727
2007 Rahmani M, Davis EM, Crabtree TR, Habibi JR, Nguyen TK, Dent P, Grant S. The kinase inhibitor sorafenib induces cell death through a process involving induction of endoplasmic reticulum stress. Molecular and Cellular Biology. 27: 5499-513. PMID 17548474 DOI: 10.1128/Mcb.01080-06  0.525
2007 Sarkar D, Lebedeva IV, Su ZZ, Park ES, Chatman L, Vozhilla N, Dent P, Curiel DT, Fisher PB. Eradication of therapy-resistant human prostate tumors using a cancer terminator virus. Cancer Research. 67: 5434-42. PMID 17545625 DOI: 10.1158/0008-5472.Can-07-0195  0.423
2007 Pei XY, Dai Y, Tenorio S, Lu J, Harada H, Dent P, Grant S. MEK1/2 inhibitors potentiate UCN-01 lethality in human multiple myeloma cells through a Bim-dependent mechanism. Blood. 110: 2092-101. PMID 17540843 DOI: 10.1182/Blood-2007-04-083204  0.555
2007 Sarkar D, Lebedeva IV, Gupta P, Emdad L, Sauane M, Dent P, Curiel DT, Fisher PB. Melanoma differentiation associated gene-7 (mda-7)/IL-24: A 'magic bullet' for cancer therapy? Expert Opinion On Biological Therapy. 7: 577-586. PMID 17477796 DOI: 10.1517/14712598.7.5.577  0.427
2007 Tsuruta Y, Pereboeva L, Glasgow JN, Rein DT, Kawakami Y, Alvarez RD, Rocconi RP, Siegal GP, Dent P, Fisher PB, Curiel DT. A mosaic fiber adenovirus serotype 5 vector containing reovirus sigma 1 and adenovirus serotype 3 knob fibers increases transduction in an ovarian cancer ex vivo system via a coxsackie and adenovirus receptor-independent pathway. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 13: 2777-83. PMID 17473211 DOI: 10.1158/1078-0432.Ccr-06-2706  0.334
2007 Valerie K, Yacoub A, Hagan MP, Curiel DT, Fisher PB, Grant S, Dent P. Radiation-induced cell signaling: inside-out and outside-in. Molecular Cancer Therapeutics. 6: 789-801. PMID 17363476 DOI: 10.1158/1535-7163.Mct-06-0596  0.502
2007 Lebedeva IV, Washington I, Sarkar D, Clark JA, Fine RL, Dent P, Curiel DT, Turro NJ, Fisher PB. Strategy for reversing resistance to a single anticancer agent in human prostate and pancreatic carcinomas. Proceedings of the National Academy of Sciences of the United States of America. 104: 3484-9. PMID 17360670 DOI: 10.1073/Pnas.0700042104  0.464
2007 Rosato RR, Almenara JA, Kolla SS, Maggio SC, Coe S, Giménez MS, Dent P, Grant S. Mechanism and functional role of XIAP and Mcl-1 down-regulation in flavopiridol/vorinostat antileukemic interactions Molecular Cancer Therapeutics. 6: 692-702. PMID 17308065 DOI: 10.1158/1535-7163.Mct-06-0562  0.491
2007 Mitchell C, Park MA, Zhang G, Han SI, Harada H, Franklin RA, Yacoub A, Li PL, Hylemon PB, Grant S, Dent P. 17-Allylamino-17-demethoxygeldanamycin enhances the lethality of deoxycholic acid in primary rodent hepatocytes and established cell lines. Molecular Cancer Therapeutics. 6: 618-32. PMID 17308059 DOI: 10.1158/1535-7163.Mct-06-0532  0.702
2007 Hagan MP, Yacoub A, Dent P. Radiation-induced PARP activation is enhanced through EGFR-ERK signaling. Journal of Cellular Biochemistry. 101: 1384-93. PMID 17295209 DOI: 10.1002/Jcb.21253  0.456
2007 Golding SE, Rosenberg E, Neill S, Dent P, Povirk LF, Valerie K. Extracellular signal-related kinase positively regulates ataxia telangiectasia mutated, homologous recombination repair, and the DNA damage response. Cancer Research. 67: 1046-53. PMID 17283137 DOI: 10.1158/0008-5472.Can-06-2371  0.455
2007 Dai Y, Khanna P, Chen S, Pei XY, Dent P, Grant S. Statins synergistically potentiate 7-hydroxystaurosporine (UCN-01) lethality in human leukemia and myeloma cells by disrupting Ras farnesylation and activation. Blood. 109: 4415-23. PMID 17264303 DOI: 10.1182/Blood-2006-09-047076  0.487
2007 Chen S, Dai Y, Harada H, Dent P, Grant S. Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation. Cancer Research. 67: 782-91. PMID 17234790 DOI: 10.1158/0008-5472.Can-06-3964  0.498
2007 Nguyen TK, Rahmani M, Harada H, Dent P, Grant S. MEK1/2 inhibitors sensitize Bcr/Abl+ human leukemia cells to the dual Abl/Src inhibitor BMS-354/825. Blood. 109: 4006-15. PMID 17218385 DOI: 10.1182/Blood-2006-09-045039  0.503
2007 Fisher PB, Sarkar D, Lebedeva IV, Emdad L, Gupta P, Sauane M, Su ZZ, Grant S, Dent P, Curiel DT, Senzer N, Nemunaitis J. Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24): novel gene therapeutic for metastatic melanoma. Toxicology and Applied Pharmacology. 224: 300-7. PMID 17208263 DOI: 10.1016/J.Taap.2006.11.021  0.448
2007 Fang Y, Studer E, Mitchell C, Grant S, Pandak WM, Hylemon PB, Dent P. Conjugated bile acids regulate hepatocyte glycogen synthase activity in vitro and in vivo via Galphai signaling. Molecular Pharmacology. 71: 1122-8. PMID 17200418 DOI: 10.1124/Mol.106.032060  0.592
2007 Yacoub A, Hawkins W, Hanna D, Young H, Park MA, Grant M, Roberts JD, Curiel DT, Fisher PB, Valerie K, Grant S, Hagan MP, Dent P. Human chorionic gonadotropin modulates prostate cancer cell survival after irradiation or HMG CoA reductase inhibitor treatment. Molecular Pharmacology. 71: 259-75. PMID 17050804 DOI: 10.1124/Mol.106.031153  0.554
2006 Yacoub A, Miller A, Caron RW, Qiao L, Curiel DA, Fisher PB, Hagan MP, Grant S, Dent P. Radiotherapy-induced signal transduction. Endocrine-Related Cancer. 13: S99-114. PMID 17259563 DOI: 10.1677/Erc.1.01271  0.488
2006 Tyler MA, Ulasov IV, Borovjagin A, Sonabend AM, Khramtsov A, Han Y, Dent P, Fisher PB, Curiel DT, Lesniak MS. Enhanced transduction of malignant glioma with a double targeted Ad5/3-RGD fiber-modified adenovirus Molecular Cancer Therapeutics. 5: 2408-2416. PMID 16985075 DOI: 10.1158/1535-7163.Mct-06-0187  0.333
2006 Yacoub A, Gilfor D, Hawkins W, Park MA, Hanna D, Hagan MP, Curiel DT, Fisher PB, Grant S, Dent P. MEK1/2 inhibition promotes Taxotere lethality in mammary tumors in vivo. Cancer Biology & Therapy. 5: 1332-9. PMID 16957420 DOI: 10.4161/Cbt.5.10.3215  0.471
2006 Pei XY, Li W, Dai Y, Dent P, Grant S. Dissecting the roles of checkpoint kinase 1/CDC2 and mitogen-activated protein kinase kinase 1/2/extracellular signal-regulated kinase 1/2 in relation to 7-hydroxystaurosporine-induced apoptosis in human multiple myeloma cells. Molecular Pharmacology. 70: 1965-73. PMID 16940414 DOI: 10.1124/Mol.106.028373  0.497
2006 Gao N, Kramer L, Rahmani M, Dent P, Grant S. The three-substituted indolinone cyclin-dependent kinase 2 inhibitor 3-[1-(3H-imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one (SU9516) kills human leukemia cells via down-regulation of Mcl-1 through a transcriptional mechanism. Molecular Pharmacology. 70: 645-55. PMID 16672643 DOI: 10.1124/Mol.106.024505  0.493
2006 Emdad L, Sarkar D, Lebedeva IV, Su ZZ, Gupta P, Mahasreshti PJ, Dent P, Curiel DT, Fisher PB. Ionizing radiation enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human ovarian cancer. Journal of Cellular Physiology. 208: 298-306. PMID 16646087 DOI: 10.1002/Jcp.20663  0.461
2006 Yacoub A, Park MA, Hanna D, Hong Y, Mitchell C, Pandya AP, Harada H, Powis G, Chen CS, Koumenis C, Grant S, Dent P. OSU-03012 promotes caspase-independent but PERK-, cathepsin B-, BID-, and AIF-dependent killing of transformed cells. Molecular Pharmacology. 70: 589-603. PMID 16622074 DOI: 10.1124/Mol.106.025007  0.707
2006 Nguyen TK, Rahmani M, Gao N, Kramer L, Corbin AS, Druker BJ, Dent P, Grant S. Synergistic interactions between DMAG and mitogen-activated protein kinase kinase 1/2 inhibitors in Bcr/abl+ leukemia cells sensitive and resistant to imatinib mesylate. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 12: 2239-47. PMID 16609040 DOI: 10.1158/1078-0432.Ccr-05-2282  0.427
2006 Lin L, Su Z, Lebedeva IV, Gupta P, Boukerche H, Rai T, Barber GN, Dent P, Sarkar D, Fisher PB. Activation of Ras/Raf protects cells from melanoma differentiation-associated gene-5-induced apoptosis. Cell Death and Differentiation. 13: 1982-93. PMID 16575407 DOI: 10.1038/Sj.Cdd.4401899  0.492
2006 Qiao L, Zhang H, Yu J, Francisco R, Dent P, Ebert MP, Röcken C, Farrell G. Constitutive activation of NF-kappaB in human hepatocellular carcinoma: evidence of a cytoprotective role. Human Gene Therapy. 17: 280-90. PMID 16544977 DOI: 10.1089/Hum.2006.17.280  0.434
2006 Lebedeva IV, Sarkar D, Su ZZ, Gopalkrishnan RV, Athar M, Randolph A, Valerie K, Dent P, Fisher PB. Molecular target-based therapy of pancreatic cancer. Cancer Research. 66: 2403-13. PMID 16489047 DOI: 10.1158/0008-5472.Can-05-3510  0.411
2006 Dasmahapatra G, Nguyen TK, Dent P, Grant S. Adaphostin and bortezomib induce oxidative injury and apoptosis in imatinib mesylate-resistant hematopoietic cells expressing mutant forms of Bcr/Abl. Leukemia Research. 30: 1263-72. PMID 16481037 DOI: 10.1016/J.Leukres.2006.01.005  0.444
2006 Dai Y, Hamm TE, Dent P, Grant S. Cyclin D1 overexpression increases the susceptibility of human U266 myeloma cells to CDK inhibitors through a process involving p130-, p107- and E2F-dependent S phase entry Cell Cycle. 5: 437-446. PMID 16479154 DOI: 10.4161/Cc.5.4.2441  0.453
2006 Gupta P, Su ZZ, Lebedeva IV, Sarkar D, Sauane M, Emdad L, Bachelor MA, Grant S, Curiel DT, Dent P, Fisher PB. mda-7/IL-24: multifunctional cancer-specific apoptosis-inducing cytokine. Pharmacology & Therapeutics. 111: 596-628. PMID 16464504 DOI: 10.1016/J.Pharmthera.2005.11.005  0.45
2006 Su ZZ, Lebedeva IV, Sarkar D, Emdad L, Gupta P, Kitada S, Dent P, Reed JC, Fisher PB. Ionizing radiation enhances therapeutic activity of mda-7/IL-24: overcoming radiation- and mda-7/IL-24-resistance in prostate cancer cells overexpressing the antiapoptotic proteins bcl-xL or bcl-2. Oncogene. 25: 2339-48. PMID 16331261 DOI: 10.1038/Sj.Onc.1209271  0.456
2006 Rosato RR, Maggio SC, Almenara JA, Payne SG, Atadja P, Spiegel S, Dent P, Grant S. The histone deacetylase inhibitor LAQ824 induces human leukemia cell death through a process involving XIAP down-regulation, oxidative injury, and the acid sphingomyelinase-dependent generation of ceramide. Molecular Pharmacology. 69: 216-25. PMID 16189296 DOI: 10.1124/Mol.105.017145  0.469
2006 Dasmahapatra G, Rahmani M, Dent P, Grant S. The tyrphostin adaphostin interacts synergistically with proteasome inhibitors to induce apoptosis in human leukemia cells through a reactive oxygen species (ROS)-dependent mechanism Blood. 107: 232-240. PMID 16166589 DOI: 10.1182/Blood-2005-06-2302  0.485
2006 Sarkar D, Dent P, Fisher PB. Melanoma differentiation associated gene-7 (mda-7)/ interleukin-24 (IL-24), mda-7/IL-24: Current perspectives on a unique member of the IL-10 family of cytokines Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry. 5: 259-274. DOI: 10.2174/187152306778017719  0.435
2005 Hawkins W, Mitchell C, McKinstry R, Gilfor D, Starkey J, Dai Y, Dawson K, Ramakrishnan V, Roberts JD, Yacoub A, Grant S, Dent P. Transient exposure of mammary tumors to PD184352 and UCN-01 causes tumor cell death in vivo and prolonged suppression of tumor regrowth. Cancer Biology & Therapy. 4: 1275-84. PMID 16319524 DOI: 10.4161/Cbt.4.11.2286  0.652
2005 Dent P, Fang Y, Gupta S, Studer E, Mitchell C, Spiegel S, Hylemon PB. Conjugated bile acids promote ERK1/2 and AKT activation via a pertussis toxin-sensitive mechanism in murine and human hepatocytes. Hepatology (Baltimore, Md.). 42: 1291-9. PMID 16317705 DOI: 10.1002/Hep.20942  0.597
2005 Rosato RR, Almenara JA, Maggio SC, Atadja P, Craig R, Vrana J, Dent P, Grant S. Potentiation of the lethality of the histone deacetylase inhibitor LAQ824 by the cyclin-dependent kinase inhibitor roscovitine in human leukemia cells Molecular Cancer Therapeutics. 4: 1772-1785. PMID 16275999 DOI: 10.1158/1535-7163.Mct-05-0157  0.529
2005 Hsu MK, Qiao L, Ho V, Zhang BH, Zhang H, Teoh N, Dent P, Farrell GC. Ethanol reduces p38 kinase activation and cyclin D1 protein expression after partial hepatectomy in rats. Journal of Hepatology. 44: 375-82. PMID 16226824 DOI: 10.1016/J.Jhep.2005.07.031  0.335
2005 Dent P, Han SI, Mitchell C, Studer E, Yacoub A, Grandis J, Grant S, Krystal GW, Hylemon PB. Inhibition of insulin/IGF-1 receptor signaling enhances bile acid toxicity in primary hepatocytes. Biochemical Pharmacology. 70: 1685-96. PMID 16207485 DOI: 10.1016/J.Bcp.2005.08.020  0.572
2005 Qiao L, Yu J, Dent P, Farrell G. NF-κB protects rat ARL-6 hepatocellular carcinoma cells against hydrogen peroxide-induced apoptosis Cancer Biology and Therapy. 4: 1195-1202. PMID 16177566 DOI: 10.4161/Cbt.4.11.2078  0.419
2005 Gao N, Rahmani M, Shi X, Dent P, Grant S. Synergistic antileukemic interactions between 2-medroxyestradiol (2-ME) and histone deacetylase inhibitors involve Akt down-regulation and oxidative stress. Blood. 107: 241-9. PMID 16141349 DOI: 10.1182/Blood-2005-06-2409  0.48
2005 Rahmani M, Davis EM, Bauer C, Dent P, Grant S. Apoptosis induced by the kinase inhibitor BAY 43-9006 in human leukemia cells involves down-regulation of Mcl-1 through inhibition of translation Journal of Biological Chemistry. 280: 35217-35227. PMID 16109713 DOI: 10.1074/Jbc.M506551200  0.541
2005 Su Z, Emdad L, Sauane M, Lebedeva IV, Sarkar D, Gupta P, James CD, Randolph A, Valerie K, Walter MR, Dent P, Fisher PB. Unique aspects of mda-7/IL-24 antitumor bystander activity: establishing a role for secretion of MDA-7/IL-24 protein by normal cells. Oncogene. 24: 7552-66. PMID 16044151 DOI: 10.1038/Sj.Onc.1208911  0.44
2005 Yu C, Dasmahapatra G, Dent P, Grant S. Synergistic interactions between MEK1/2 and histone deacetylase inhibitors in BCR/ABL+ human leukemia cells Leukemia. 19: 1579-1589. PMID 16015388 DOI: 10.1038/Sj.Leu.2403868  0.496
2005 Dent P, Yacoub A, Grant S. DMC: Novel celecoxib derivatives to rap cancer Cancer Biology and Therapy. 4: 583-584. PMID 15970676 DOI: 10.4161/Cbt.4.5.1794  0.349
2005 Dai Y, Rahmani M, Dent P, Grant S. Blockade of histone deacetylase inhibitor-induced RelA/p65 acetylation and NF-κB activation potentiates apoptosis in leukemia cells through a process mediated by oxidative damage, XIAP downregulation, and c-Jun N-terminal kinase 1 activation Molecular and Cellular Biology. 25: 5429-5444. PMID 15964800 DOI: 10.1128/Mcb.25.13.5429-5444.2005  0.455
2005 Pei XY, Dai Y, Rahmani M, Li W, Dent P, Grant S. The farnesyltransferase inhibitor L744832 potentiates UCN-01-induced apoptosis in human multiple myeloma cells. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 11: 4589-600. PMID 15958645 DOI: 10.1158/1078-0432.Ccr-04-2346  0.448
2005 Dent P, Yacoub A, Grant S, Curiel DT, Fisher PB. MDA-7/IL-24 regulates proliferation, invasion and tumor cell radiosensitivity: A new cancer therapy? Journal of Cellular Biochemistry. 95: 712-719. PMID 15880678 DOI: 10.1002/Jcb.20502  0.427
2005 Gao N, Rahmani M, Dent P, Grant S. 2-Methoxyestradiol-induced apoptosis in human leukemia cells proceeds through a reactive oxygen species and Akt-dependent process Oncogene. 24: 3797-3809. PMID 15782127 DOI: 10.1038/Sj.Onc.1208530  0.47
2005 Rahmani M, Reese E, Dai Y, Bauer C, Payne SG, Dent P, Spiegel S, Grant S. Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species. Cancer Research. 65: 2422-32. PMID 15781658 DOI: 10.1158/0008-5472.Can-04-2440  0.542
2005 Shore SM, Byers SA, Dent P, Price DH. Characterization of Cdk9(55) and differential regulation of two Cdk9 isoforms. Gene. 350: 51-8. PMID 15780980 DOI: 10.1016/J.Gene.2005.01.015  0.418
2005 Hahn M, Li W, Yu C, Rahmani M, Dent P, Grant S. Rapamycin and UCN-01 synergistically induce apoptosis in human leukemia cells through a process that is regulated by the Raf-1/MEK/ERK, Akt, and JNK signal transduction pathways. Molecular Cancer Therapeutics. 4: 457-70. PMID 15767555 DOI: 10.1158/1535-7163.Mct-04-0137  0.53
2005 Carón RW, Yacoub A, Li M, Zhu X, Mitchell C, Hong Y, Hawkins W, Sasazuki T, Shirasawa S, Kozikowski AP, Dennis PA, Hagan MP, Grant S, Dent P. Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival. Molecular Cancer Therapeutics. 4: 257-70. PMID 15713897  0.595
2005 Carón RW, Yacoub A, Zhu X, Mitchell C, Han SI, Sasazuki T, Shirasawa S, Hagan MP, Grant S, Dent P. H-RAS V12-induced radioresistance in HCT116 colon carcinoma cells is heregulin dependent. Molecular Cancer Therapeutics. 4: 243-55. PMID 15713896  0.572
2005 Su ZZ, Emdad L, Sarkar D, Randolph A, Valerie K, Yacoub A, Dent P, Fisher PB. Potential molecular mechanism for rodent tumorigenesis: mutational generation of Progression Elevated Gene-3 (PEG-3). Oncogene. 24: 2247-55. PMID 15674324 DOI: 10.1038/Sj.Onc.1208420  0.433
2005 Carón RW, Yacoub A, Mitchell C, Zhu X, Hong Y, Sasazuki T, Shirasawa S, Hagan MP, Grant S, Dent P. Radiation-stimulated ERK1/2 and JNK1/2 signaling can promote cell cycle progression in human colon cancer cells. Cell Cycle (Georgetown, Tex.). 4: 456-64. PMID 15655348 DOI: 10.4161/Cc.4.3.1249  0.623
2005 Rahmani M, Reese E, Dai Y, Bauer C, Kramer LB, Huang M, Jove R, Dent P, Grant S. Cotreatment with suberanoylanilide hydroxamic acid and 17-allylamino 17-demethoxygeldanamycin synergistically induces apoptosis in Bcr-Abl+ Cells sensitive and resistant to STI571 (imatinib mesylate) in association with down-regulation of Bcr-Abl, abrogation of signal transducer and activator of transcription 5 activity, and Bax conformational change. Molecular Pharmacology. 67: 1166-76. PMID 15625278 DOI: 10.1124/Mol.104.007831  0.515
2005 Lebedeva IV, Sauane M, Gopalkrishnan RV, Sarkar D, Su ZZ, Gupta P, Nemunaitis J, Cunningham C, Yacoub A, Dent P, Fisher PB. mda-7/IL-24: exploiting cancer's Achilles' heel. Molecular Therapy : the Journal of the American Society of Gene Therapy. 11: 4-18. PMID 15585401 DOI: 10.1016/J.Ymthe.2004.08.012  0.419
2005 Lebedeva IV, Su ZZ, Sarkar D, Gopalkrishnan RV, Waxman S, Yacoub A, Dent P, Fisher PB. Induction of reactive oxygen species renders mutant and wild-type K-ras pancreatic carcinoma cells susceptible to Ad.mda-7-induced apoptosis. Oncogene. 24: 585-96. PMID 15580305 DOI: 10.1038/Sj.Onc.1208183  0.514
2005 Dai Y, Rahmani M, Pei XY, Khanna P, Han SI, Mitchell C, Dent P, Grant S. Farnesyltransferase inhibitors interact synergistically with the Chk1 inhibitor UCN-01 to induce apoptosis in human leukemia cells through interruption of both Akt and MEK/ERK pathways and activation of SEK1/JNK. Blood. 105: 1706-16. PMID 15494423 DOI: 10.1182/Blood-2004-07-2767  0.684
2004 Dent P, Grant S. Irofulven: Resurgence for alkylating therapy in cancer? Cancer Biology and Therapy. 3: 1143-1144. PMID 15640616 DOI: 10.4161/Cbt.3.11.1306  0.372
2004 Ahmed W, Rahmani M, Dent P, Grant S. The cyclin-dependent kinase inhibitor p21CIP1/WAF1 blocks paclitaxel-induced G2M arrest and attenuates mitochondrial injury and apoptosis in p53-null human leukemia cells Cell Cycle. 3: 1305-1311. PMID 15467449 DOI: 10.4161/Cc.3.10.1161  0.529
2004 Fang Y, Han SI, Mitchell C, Gupta S, Studer E, Grant S, Hylemon PB, Dent P. Bile acids induce mitochondrial ROS, which promote activation of receptor tyrosine kinases and signaling pathways in rat hepatocytes. Hepatology (Baltimore, Md.). 40: 961-71. PMID 15382121 DOI: 10.1002/hep.20385  0.638
2004 Sauane M, Gopalkrishnan RV, Choo HT, Gupta P, Lebedeva IV, Yacoub A, Dent P, Fisher PB. Mechanistic aspects of mda-7/IL-24 cancer cell selectivity analysed via a bacterial fusion protein. Oncogene. 23: 7679-90. PMID 15334067 DOI: 10.1038/Sj.Onc.1207958  0.466
2004 Leath CA, Kataram M, Bhagavatula P, Gopalkrishnan RV, Dent P, Fisher PB, Pereboev A, Carey D, Lebedeva IV, Haisma HJ, Alvarez RD, Curiel DT, Mahasreshti PJ. Infectivity enhanced adenoviral-mediated mda-7/IL-24 gene therapy for ovarian carcinoma. Gynecologic Oncology. 94: 352-62. PMID 15297172 DOI: 10.1016/J.Ygyno.2004.04.028  0.424
2004 Gao N, Dai Y, Rahmani M, Dent P, Grant S. Contribution of disruption of the nuclear factor-kappaB pathway to induction of apoptosis in human leukemia cells by histone deacetylase inhibitors and flavopiridol. Molecular Pharmacology. 66: 956-63. PMID 15235103 DOI: 10.1124/Mol.104.002014  0.474
2004 Yacoub A, Mitchell C, Hong Y, Gopalkrishnan RV, Su ZZ, Gupta P, Sauane M, Lebedeva IV, Curiel DT, Mahasreshti PJ, Rosenfeld MR, Broaddus WC, James CD, Grant S, Fisher PB, ... Dent P, et al. MDA-7 regulates cell growth and radiosensitivity in vitro of primary (non-established) human glioma cells. Cancer Biology & Therapy. 3: 739-51. PMID 15197348 DOI: 10.4161/Cbt.3.8.968  0.722
2004 Dai Y, Rahmani M, Corey SJ, Dent P, Grant S. A Bcr/Abl-independent, Lyn-dependent form of imatinib mesylate (STI-571) resistance is associated with altered expression of Bcl-2. The Journal of Biological Chemistry. 279: 34227-39. PMID 15175350 DOI: 10.1074/Jbc.M402290200  0.511
2004 Sauane M, Lebedeva IV, Su ZZ, Choo HT, Randolph A, Valerie K, Dent P, Gopalkrishnan RV, Fisher PB. Melanoma differentiation associated gene-7/interleukin-24 promotes tumor cell-specific apoptosis through both secretory and nonsecretory pathways. Cancer Research. 64: 2988-93. PMID 15126330 DOI: 10.1158/0008-5472.Can-04-0200  0.463
2004 Grant S, Dent P. Activation of MAP kinase pathways by TRAIL: Don't expect the obvious Cancer Biology and Therapy. 3: 302-304. PMID 15107606 DOI: 10.4161/Cbt.3.3.749  0.41
2004 Yu C, Rahmani M, Dent P, Grant S. The hierarchical relationship between MAPK signaling and ROS generation in human leukemia cells undergoing apoptosis in response to the proteasome inhibitor Bortezomib Experimental Cell Research. 295: 555-566. PMID 15093752 DOI: 10.1016/J.Yexcr.2004.02.001  0.523
2004 Grant S, Dent P. Kinase Inhibitors and Cytotoxic Drug Resistance Clinical Cancer Research. 10: 2205-2207. PMID 15073093 DOI: 10.1158/1078-0432.Ccr-0001-4  0.407
2004 Dai Y, Rahmani M, Pei XY, Dent P, Grant S. Bortezomib and flavopiridol interact synergistically to induce apoptosis in chronic myeloid leukemia cells resistant to imatinib mesylate through both Bcr/Abl-dependent and -independent mechanisms. Blood. 104: 509-18. PMID 15039284 DOI: 10.1182/Blood-2003-12-4121  0.537
2004 Han SI, Studer E, Gupta S, Fang Y, Qiao L, Li W, Grant S, Hylemon PB, Dent P. Bile Acids Enhance the Activity of the Insulin Receptor and Glycogen Synthase in Primary Rodent Hepatocytes Hepatology. 39: 456-463. PMID 14767998 DOI: 10.1002/Hep.20043  0.34
2004 Yacoub A, Han SI, Caron R, Gilfor D, Mooberry S, Grant S, Dent P. Sequence dependent exposure of mammary carcinoma cells to Taxotere and the MEK1/2 inhibitor U0126 causes enhanced cell killing in vitro. Cancer Biology & Therapy. 2: 670-6. PMID 14688474  0.505
2004 Gupta S, Natarajan R, Payne SG, Studer EJ, Spiegel S, Dent P, Hylemon PB. Deoxycholic acid activates the c-Jun N-terminal kinase pathway via FAS receptor activation in primary hepatocytes. Role of acidic sphingomyelinase-mediated ceramide generation in FAS receptor activation. The Journal of Biological Chemistry. 279: 5821-8. PMID 14660582 DOI: 10.1074/Jbc.M310979200  0.397
2004 Yu C, Rahmani M, Almenara J, Sausville EA, Dent P, Grant S. Induction of apoptosis in human leukemia cells by the tyrosine kinase inhibitor adaphostin proceeds through a RAF-1/MEK/ERK- and AKT-dependent process Oncogene. 23: 1364-1376. PMID 14647418 DOI: 10.1038/Sj.Onc.1207248  0.476
2004 Dai Y, Pei XY, Rahmani M, Conrad DH, Dent P, Grant S. Interruption of the NF-kappaB pathway by Bay 11-7082 promotes UCN-01-mediated mitochondrial dysfunction and apoptosis in human multiple myeloma cells. Blood. 103: 2761-70. PMID 14645003 DOI: 10.1182/Blood-2003-09-3037  0.525
2004 Dai Y, Rahmani M, Pei X, Khanna P, Dent P, Grant S. Highly Synergistic Interaction between Farnesyltransferase Inhibitors and the Chk1 Inhibitor UCN-01 to Induce Apoptosis in Human Leukemia Cells through Interruption of Both Akt and MEK/ERK Pathways and Activation of SEK1/JNK. Blood. 104: 3403-3403. DOI: 10.1182/Blood.V104.11.3403.3403  0.509
2004 Rahmani M, Reese E, Dai Y, Bauer C, Kramer L, Huang M, Jove R, Dent P, Grant S. Co-Administration of SAHA and 17-AAG Synergistically Induces Apoptosis in Bcr-Abl+ Cells Sensitive and Resistant to STI-571 in Association with Down-Regulation of Bcr-Abl, Abrogation of STAT5 Activity, and Bax Conformational Change. Blood. 104: 1995-1995. DOI: 10.1182/Blood.V104.11.1995.1995  0.497
2004 Fang Y, Han SI, Mitchell C, Gupta S, Studer E, Grant S, Hylemon PB, Dent P. Bile acids induce mitochondrial ROS, which promote activation of receptor tyrosine kinases and signaling pathways in rat hepatocytes Hepatology. 40: 961-971. DOI: 10.1002/Hep.1840400427  0.675
2003 Lebedeva IV, Su ZZ, Sarkar D, Kitada S, Dent P, Waxman S, Reed JC, Fisher PB. Melanoma differentiation associated gene-7, mda-7/interleukin-24, induces apoptosis in prostate cancer cells by promoting mitochondrial dysfunction and inducing reactive oxygen species. Cancer Research. 63: 8138-44. PMID 14678967  0.304
2003 Lebedeva IV, Sarkar D, Su ZZ, Kitada S, Dent P, Stein CA, Reed JC, Fisher PB. Bcl-2 and Bcl-x(L) differentially protect human prostate cancer cells from induction of apoptosis by melanoma differentiation associated gene-7, mda-7/IL-24. Oncogene. 22: 8758-73. PMID 14647471 DOI: 10.1038/Sj.Onc.1206891  0.43
2003 Dai Y, Dent P, Grant S. Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) Promotes Mitochondrial Dysfunction and Apoptosis Induced by 7-Hydroxystaurosporine and Mitogen-Activated Protein Kinase Kinase Inhibitors in Human Leukemia Cells That Ectopically Express Bcl-2 and Bcl-xL Molecular Pharmacology. 64: 1402-1409. PMID 14645670 DOI: 10.1124/Mol.64.6.1402  0.518
2003 Yu C, Subler M, Rahmani M, Reese E, Krystal G, Conrad D, Dent P, Grant S. Induction of apoptosis in BCR/ABL+ cells by histone deacetylase inhibitors involves reciprocal effects on the RAF/MEK/ERK and JNK pathways. Cancer Biology & Therapy. 2: 544-51. PMID 14614324 DOI: 10.4161/Cbt.2.5.454  0.537
2003 Yacoub A, Mitchell C, Lebedeva IV, Sarkar D, Su ZZ, McKinstry R, Gopalkrishnan RV, Grant S, Fisher PB, Dent P. mda-7 (IL-24) Inhibits growth and enhances radiosensitivity of glioma cells in vitro via JNK signaling. Cancer Biology & Therapy. 2: 347-53. PMID 14508103 DOI: 10.4161/Cbt.2.4.422  0.698
2003 Fisher PB, Gopalkrishnan RV, Chada S, Ramesh R, Grimm EA, Rosenfeld MR, Curiel DT, Dent P. mda-7/IL-24, a novel cancer selective apoptosis inducing cytokine gene: from the laboratory into the clinic. Cancer Biology & Therapy. 2: S23-37. PMID 14508078 DOI: 10.4161/Cbt.458  0.327
2003 Rahmani M, Yu C, Reese E, Ahmed W, Hirsch K, Dent P, Grant S. Inhibition of PI-3 kinase sensitizes human leukemic cells to histone deacetylase inhibitor-mediated apoptosis through p44/42 MAP kinase inactivation and abrogation of p21(CIP1/WAF1) induction rather than AKT inhibition. Oncogene. 22: 6231-42. PMID 13679862 DOI: 10.1038/Sj.Onc.1206646  0.529
2003 Yacoub A, Mitchell C, Lister A, Lebedeva IV, Sarkar D, Su ZZ, Sigmon C, McKinstry R, Ramakrishnan V, Qiao L, Broaddus WC, Gopalkrishnan RV, Grant S, Fisher PB, Dent P. Melanoma differentiation-associated 7 (interleukin 24) inhibits growth and enhances radiosensitivity of glioma cells in vitro and in vivo. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 9: 3272-81. PMID 12960112  0.551
2003 Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S. MAPK pathways in radiation responses. Oncogene. 22: 5885-96. PMID 12947395 DOI: 10.1038/Sj.Onc.1206701  0.431
2003 Lammering G, Hewit TH, Valerie K, Contessa JN, Amorino GP, Dent P, Schmidt-Ullrich RK. EGFRvIII-mediated radioresistance through a strong cytoprotective response. Oncogene. 22: 5545-53. PMID 12944901 DOI: 10.1038/Sj.Onc.1206788  0.492
2003 Yu C, Rahmani M, Conrad D, Subler M, Dent P, Grant S. The proteasome inhibitor bortezomib interacts synergistically with histone deacetylase inhibitors to induce apoptosis in Bcr/Abl+ cells sensitive and resistant to STI571. Blood. 102: 3765-74. PMID 12893773 DOI: 10.1182/Blood-2003-03-0737  0.544
2003 Yacoub A, Mitchell C, Brannon J, Rosenberg E, Qiao L, McKinstry R, Linehan WM, Su ZS, Sarkar D, Lebedeva IV, Valerie K, Gopalkrishnan RV, Grant S, Fisher PB, Dent P. MDA-7 (interleukin-24) inhibits the proliferation of renal carcinoma cells and interacts with free radicals to promote cell death and loss of reproductive capacity. Molecular Cancer Therapeutics. 2: 623-32. PMID 12883035  0.625
2003 Sauane M, Gopalkrishnan RV, Lebedeva I, Mei MX, Sarkar D, Su ZZ, Kang DC, Dent P, Pestka S, Fisher PB. Mda-7/IL-24 induces apoptosis of diverse cancer cell lines through JAK/STAT-independent pathways. Journal of Cellular Physiology. 196: 334-45. PMID 12811827 DOI: 10.1002/Jcp.10309  0.436
2003 Kinoshita I, Leaner V, Katabami M, Manzano RG, Dent P, Sabichi A, Birrer MJ. Identification of cJun-responsive genes in Rat-1a cells using multiple techniques: increased expression of stathmin is necessary for cJun-mediated anchorage-independent growth. Oncogene. 22: 2710-22. PMID 12743595 DOI: 10.1038/Sj.Onc.1206371  0.352
2003 Jia W, Yu C, Rahmani M, Krystal G, Sausville EA, Dent P, Grant S. Synergistic antileukemic interactions between 17-AAG and UCN-01 involve interruption of RAF/MEK- and AKT-related pathways. Blood. 102: 1824-32. PMID 12738674 DOI: 10.1182/Blood-2002-12-3785  0.537
2003 Yu C, Rahmani M, Almenara J, Subler M, Krystal G, Conrad D, Varticovski L, Dent P, Grant S. Histone deacetylase inhibitors promote STI571-mediated apoptosis in STI571-sensitive and -resistant Bcr/Abl+ human myeloid leukemia cells. Cancer Research. 63: 2118-26. PMID 12727828  0.471
2003 Dent P, Qiao L, Gilfor D, Birrer M, Grant S, Fisher PB. The regulation of tumor suppressor genes by oncogenes. Methods in Molecular Biology (Clifton, N.J.). 222: 269-92. PMID 12710693 DOI: 10.1385/1-59259-328-3:269  0.34
2003 Yu C, Rahmani M, Dai Y, Conrad D, Krystal G, Dent P, Grant S. The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process. Cancer Research. 63: 1822-33. PMID 12702569  0.447
2003 Qiao L, Han SI, Fang Y, Park JS, Gupta S, Gilfor D, Amorino G, Valerie K, Sealy L, Engelhardt JF, Grant S, Hylemon PB, Dent P. Bile acid regulation of C/EBPbeta, CREB, and c-Jun function, via the extracellular signal-regulated kinase and c-Jun NH2-terminal kinase pathways, modulates the apoptotic response of hepatocytes. Molecular and Cellular Biology. 23: 3052-66. PMID 12697808 DOI: 10.1128/Mcb.23.9.3052-3066.2003  0.406
2003 Yacoub A, McKinstry R, Hinman D, Chung T, Dent P, Hagan MP. Epidermal growth factor and ionizing radiation up-regulate the DNA repair genes XRCC1 and ERCC1 in DU145 and LNCaP prostate carcinoma through MAPK signaling. Radiation Research. 159: 439-52. PMID 12643788 DOI: 10.1667/0033-7587(2003)159[0439:Egfair]2.0.Co;2  0.39
2003 Su ZZ, Lebedeva IV, Sarkar D, Gopalkrishnan RV, Sauane M, Sigmon C, Yacoub A, Valerie K, Dent P, Fisher PB. Melanoma differentiation associated gene-7, mda-7/IL-24, selectively induces growth suppression, apoptosis and radiosensitization in malignant gliomas in a p53-independent manner. Oncogene. 22: 1164-80. PMID 12606943 DOI: 10.1038/Sj.Onc.1206062  0.446
2003 Dent P, Yacoub A, Contessa J, Caron R, Amorino G, Valerie K, Hagan MP, Grant S, Schmidt-Ullrich R. Stress and radiation-induced activation of multiple intracellular signaling pathways. Radiation Research. 159: 283-300. PMID 12600231 DOI: 10.1667/0033-7587(2003)159[0283:Sariao]2.0.Co;2  0.425
2003 Cartee L, Maggio SC, Smith R, Sankala HM, Dent P, Grant S. Protein kinase C-dependent activation of the tumor necrosis factor receptor-mediated extrinsic cell death pathway underlies enhanced apoptosis in human myeloid leukemia cells exposed to bryostatin 1 and flavopiridol Molecular Cancer Therapeutics. 2: 83-93. PMID 12533676  0.455
2003 Wang S, Wang Z, Dent P, Grant S. Induction of tumor necrosis factor by bryostatin 1 is involved in synergistic interactions with paclitaxel in human myeloid leukemia cells. Blood. 101: 3648-57. PMID 12522001 DOI: 10.1182/Blood-2002-09-2739  0.491
2003 Cottom J, Salvador LM, Maizels ET, Reierstad S, Park Y, Carr DW, Davare MA, Hell JW, Palmer SS, Dent P, Kawakatsu H, Ogata M, Hunzicker-Dunn M. Follicle-stimulating hormone activates extracellular signal-regulated kinase but not extracellular signal-regulated kinase kinase through a 100-kDa phosphotyrosine phosphatase. The Journal of Biological Chemistry. 278: 7167-79. PMID 12493768 DOI: 10.1074/Jbc.M203901200  0.446
2003 Sauane M, Gopalkrishnan RV, Sarkar D, Su ZZ, Lebedeva IV, Dent P, Pestka S, Fisher PB. MDA-7/IL-24: novel cancer growth suppressing and apoptosis inducing cytokine. Cytokine & Growth Factor Reviews. 14: 35-51. PMID 12485618 DOI: 10.1016/S1359-6101(02)00074-6  0.399
2003 Jacobs-Helber SM, Roh KH, Bailey D, Dessypris EN, Ryan JJ, Chen J, Wickrema A, Barber DL, Dent P, Sawyer ST. Tumor necrosis factor-alpha expressed constitutively in erythroid cells or induced by erythropoietin has negative and stimulatory roles in normal erythropoiesis and erythroleukemia. Blood. 101: 524-31. PMID 12393629 DOI: 10.1182/Blood-2001-11-0084  0.374
2003 Hagan MP, Yacoub A, Dent P. The switch from DNA repair to apoptosis: discovery of a refractory period for radiation-induced EGFR-MAPK signaling following irradiation International Journal of Radiation Oncology Biology Physics. 57. DOI: 10.1016/S0360-3016(03)01154-4  0.324
2003 Gupta S, Studer EJ, Payne SG, Dent P, Hylemon PB. Deoxycholic acid activates the c-Jun N-terminal kinase (JNK) pathway via activation of the FAS receptor Gastroenterology. 124: A727. DOI: 10.1016/S0016-5085(03)83673-9  0.351
2002 Yu C, Dai Y, Dent P, Grant S. Coadministration of UCN-01 with MEK1/2 inhibitors potently induces apoptosis in BCR/ABL+ leukemia cells sensitive and resistant to STI571 Cancer Biology and Therapy. 1: 674-682. PMID 12642693 DOI: 10.4161/Cbt.319  0.483
2002 Grant S, Dent P. Conversion of drug-induced differentiation to apoptosis by pharmacologic cyclin-dependent kinase inhibitors Cell Cycle (Georgetown, Tex.). 1: 383-388. PMID 12548009 DOI: 10.4161/Cc.1.6.260  0.511
2002 Dent P. Ribonucleotide reductase inhibition: regulation of the radiosensitive phenotype via NF kappa B and Bcl-2 Cancer Biology &Amp; Therapy. 1: 546-547. PMID 12496486 DOI: 10.4161/Cbt.1.5.175  0.397
2002 Grant S, Fisher PB, Dent P. The role of signal transduction pathways in drug and radiation resistance Cancer Treatment and Research. 112: 89-108. PMID 12481713 DOI: 10.1007/978-1-4615-1173-1_5  0.381
2002 McKinstry R, Qiao L, Yacoub A, Dai Y, Decker R, Holt S, Hagan MP, Grant S, Dent P. Inhibitors of MEK1/2 interact with UCN-01 to induce apoptosis and reduce colony formation in mammary and prostate carcinoma cells. Cancer Biology & Therapy. 1: 243-53. PMID 12432271 DOI: 10.4161/Cbt.75  0.551
2002 Dai Y, Dent P, Grant S. Induction of apoptosis in human leukemia cells by the CDK1 inhibitor CGP74514A Cell Cycle (Georgetown, Tex.). 1: 143-152. PMID 12429924  0.419
2002 Condorelli G, Morisco C, Latronico MV, Claudio PP, Dent P, Tsichlis P, Condorelli G, Frati G, Drusco A, Croce CM, Napoli C. TNF-alpha signal transduction in rat neonatal cardiac myocytes: definition of pathways generating from the TNF-alpha receptor. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 16: 1732-7. PMID 12409315 DOI: 10.1096/Fj.02-0419Com  0.374
2002 Dai Y, Landowski TH, Rosen ST, Dent P, Grant S. Combined treatment with the checkpoint abrogator UCN-01 and MEK1/2 inhibitors potently induces apoptosis in drug-sensitive and -resistant myeloma cells through an IL-6-independent mechanism. Blood. 100: 3333-43. PMID 12384435 DOI: 10.1182/Blood-2002-03-0940  0.427
2002 Yu C, Krystal G, Dent P, Grant S. Flavopiridol potentiates STI571-induced mitochondrial damage and apoptosis in BCR-ABL-positive human leukemia cells Clinical Cancer Research. 8: 2976-2984. PMID 12231544  0.442
2002 Qiao L, Yacoub A, McKinstry R, Park JS, Caron R, Fisher PB, Hagan MP, Grant S, Dent P. Pharmocologic inhibitors of the mitogen activated protein kinase cascade have the potential to interact with ionizing radiation exposure to induce cell death in carcinoma cells by multiple mechanisms. Cancer Biology & Therapy. 1: 168-76. PMID 12170777 DOI: 10.4161/Cbt.64  0.468
2002 Decker RH, Wang S, Dai Y, Dent P, Grant S. Loss of the Bcl-2 phosphorylation loop domain is required to protect human myeloid leukemia cells from flavopiridol-mediated mitochondrial damage and apoptosis. Cancer Biology & Therapy. 1: 136-44. PMID 12170773 DOI: 10.4161/Cbt.58  0.488
2002 Amorino GP, Hamilton VM, Valerie K, Dent P, Lammering G, Schmidt-Ullrich RK. Epidermal growth factor receptor dependence of radiation-induced transcription factor activation in human breast carcinoma cells. Molecular Biology of the Cell. 13: 2233-44. PMID 12134064 DOI: 10.1091/Mbc.01-12-0572  0.412
2002 Cartee L, Sankala H, Davis C, Smith R, Maggio S, Lin PS, Dent P, Grant S. 7-hydroxystaurosporine (UCN-01) and ionizing radiation combine to inhibit the growth of Bcl-2-overexpressing U937 leukemia cells through a non-apoptotic mechanism. International Journal of Oncology. 21: 351-9. PMID 12118331  0.36
2002 Su ZZ, Gopalkrishnan RV, Narayan G, Dent P, Fisher PB. Progression elevated gene-3, PEG-3, induces genomic instability in rodent and human tumor cells. Journal of Cellular Physiology. 192: 34-44. PMID 12115734 DOI: 10.1002/Jcp.10114  0.431
2002 Sarkar D, Su ZZ, Lebedeva IV, Sauane M, Gopalkrishnan RV, Valerie K, Dent P, Fisher PB. mda-7 (IL-24) Mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK. Proceedings of the National Academy of Sciences of the United States of America. 99: 10054-9. PMID 12114539 DOI: 10.1073/Pnas.152327199  0.498
2002 Qiao L, McKinstry R, Gupta S, Gilfor D, Windle JJ, Hylemon PB, Grant S, Fisher PB, Dent P. Cyclin kinase inhibitor p21 potentiates bile acid-induced apoptosis in hepatocytes that is dependent on p53. Hepatology (Baltimore, Md.). 36: 39-48. PMID 12085347 DOI: 10.1053/Jhep.2002.33899  0.451
2002 Manzano RG, Montuenga LM, Dayton M, Dent P, Kinoshita I, Vicent S, Gardner GJ, Nguyen P, Choi YH, Trepel J, Auersperg N, Birrer MJ. CL100 expression is down-regulated in advanced epithelial ovarian cancer and its re-expression decreases its malignant potential. Oncogene. 21: 4435-47. PMID 12080474 DOI: 10.1038/Sj.Onc.1205542  0.402
2002 Contessa JN, Hampton J, Lammering G, Mikkelsen RB, Dent P, Valerie K, Schmidt-Ullrich RK. Ionizing radiation activates Erb-B receptor dependent Akt and p70 S6 kinase signaling in carcinoma cells. Oncogene. 21: 4032-41. PMID 12037685 DOI: 10.1038/Sj.Onc.1205500  0.421
2002 Cartee L, Smith R, Dai Y, Rahmani M, Rosato R, Almenara J, Dent P, Grant S. Synergistic induction of apoptosis in human myeloid leukemia cells by phorbol 12-myristate 13-acetate and flavopiridol proceeds via activation of both the intrinsic and tumor necrosis factor-mediated extrinsic cell death pathways. Molecular Pharmacology. 61: 1313-21. PMID 12021392 DOI: 10.1124/Mol.61.6.1313  0.533
2002 Qiao L, Yacoub A, Studer E, Gupta S, Pei XY, Grant S, Hylemon PB, Dent P. Inhibition of the MAPK and PI3K pathways enhances UDCA-induced apoptosis in primary rodent hepatocytes. Hepatology (Baltimore, Md.). 35: 779-89. PMID 11915023 DOI: 10.1053/Jhep.2002.32533  0.507
2002 Shvartsman SY, Hagan MP, Yacoub A, Dent P, Wiley HS, Lauffenburger DA. Autocrine loops with positive feedback enable context-dependent cell signaling. American Journal of Physiology. Cell Physiology. 282: C545-59. PMID 11832340 DOI: 10.1152/Ajpcell.00260.2001  0.386
2002 Rao YP, Studer EJ, Stravitz RT, Gupta S, Qiao L, Dent P, Hylemon PB. Activation of the Raf-1/MEK/ERK cascade by bile acids occurs via the epidermal growth factor receptor in primary rat hepatocytes. Hepatology (Baltimore, Md.). 35: 307-14. PMID 11826403 DOI: 10.1053/Jhep.2002.31104  0.412
2002 Grant S, Qiao L, Dent P. Roles of ERBB family receptor tyrosine kinases, and downstream signaling pathways, in the control of cell growth and survival Frontiers in Bioscience : a Journal and Virtual Library. 7. PMID 11815285 DOI: 10.2741/Grant  0.45
2002 Yu C, Krystal G, Varticovksi L, McKinstry R, Rahmani M, Dent P, Grant S. Pharmacologic mitogen-activated protein/extracellular signal-regulated kinase kinase/mitogen-activated protein kinase inhibitors interact synergistically with STI571 to induce apoptosis in Bcr/Abl-expressing human leukemia cells. Cancer Research. 62: 188-99. PMID 11782377  0.409
2002 Broustas CG, Grammatikakis N, Eto M, Dent P, Brautigan DL, Kasid U. Phosphorylation of the myosin-binding subunit of myosin phosphatase by Raf-1 and inhibition of phosphatase activity. The Journal of Biological Chemistry. 277: 3053-9. PMID 11719507 DOI: 10.1074/Jbc.M106343200  0.345
2002 Dai Y, Dent P, Grant S. Induction of Apoptosis in Human Leukemia Cells by the CDK1 Inhibitor Cell Cycle. 1: 128-137. DOI: 10.4161/Cc.1.2.116  0.497
2002 Cartee L, Sankala H, Davis C, Smith R, Maggio S, Lin P, Dent P, Grant S. 7-hydroxystaurosporine (UCN-01) and ionizing radiation combine to inhibit the growth of Bcl-2-overexpressing U937 leukemia cells through a non-apoptotic mechanism. International Journal of Oncology. 21: 351-359. DOI: 10.3892/Ijo.21.2.351  0.464
2001 Grant S, Dent P. Overview: Rational integration of agents directed at novel therapeutic targets into combination chemotherapeutic regimens Current Opinion in Investigational Drugs. 2: 1600-1605. PMID 11763164  0.347
2001 Yacoub A, Park JS, Qiao L, Dent P, Hagan MP. MAPK dependence of DNA damage repair: ionizing radiation and the induction of expression of the DNA repair genes XRCC1 and ERCC1 in DU145 human prostate carcinoma cells in a MEK1/2 dependent fashion. International Journal of Radiation Biology. 77: 1067-78. PMID 11682011 DOI: 10.1080/09553000110069317  0.32
2001 Qiao L, Leach K, McKinstry R, Gilfor D, Yacoub A, Park JS, Grant S, Hylemon PB, Fisher PB, Dent P. Hepatitis B virus X protein increases expression of p21Cip-1/WAF1/MDA6 and p27Kip-1 in primary mouse hepatocytes, leading to reduced cell cycle progression Hepatology. 34: 906-917. PMID 11679961 DOI: 10.1053/Jhep.2001.28886  0.386
2001 Leszczyniecka M, Roberts T, Dent P, Grant S, Fisher PB. Differentiation therapy of human cancer: basic science and clinical applications. Pharmacology & Therapeutics. 90: 105-56. PMID 11578655 DOI: 10.1016/S0163-7258(01)00132-2  0.394
2001 Qiao L, Studer E, Leach K, McKinstry R, Gupta S, Decker R, Kukreja R, Valerie K, Nagarkatti P, El Deiry W, Molkentin J, Schmidt-Ullrich R, Fisher PB, Grant S, Hylemon PB, ... Dent P, et al. Deoxycholic acid (DCA) causes ligand-independent activation of epidermal growth factor receptor (EGFR) and FAS receptor in primary hepatocytes: Inhibition of EGFR/mitogen-activated protein kinase-signaling module enhances DCA-induced apoptosis Molecular Biology of the Cell. 12: 2629-2645. PMID 11553704 DOI: 10.1091/Mbc.12.9.2629  0.52
2001 Yu C, Wang Z, Dent P, Grant S. MEK1/2 inhibitors promote ara-C-induced apoptosis but not loss of δψm HL-60 cells Biochemical and Biophysical Research Communications. 286: 1011-1018. PMID 11527401 DOI: 10.1006/Bbrc.2001.5513  0.416
2001 Su Z, Lebedeva IV, Gopalkrishnan RV, Goldstein NI, Stein CA, Reed JC, Dent P, Fisher PB. A combinatorial approach for selectively inducing programmed cell death in human pancreatic cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 98: 10332-7. PMID 11526239 DOI: 10.1073/Pnas.171315198  0.47
2001 Park JS, Qiao L, Su ZZ, Hinman D, Willoughby K, McKinstry R, Yacoub A, Duigou GJ, Young CS, Grant S, Hagan MP, Ellis E, Fisher PB, Dent P. Ionizing radiation modulates vascular endothelial growth factor (VEGF) expression through multiple mitogen activated protein kinase dependent pathways. Oncogene. 20: 3266-80. PMID 11423976 DOI: 10.1038/Sj.Onc.1204258  0.448
2001 Lammering G, Hewit TH, Hawkins WT, Contessa JN, Reardon DB, Lin PS, Valerie K, Dent P, Mikkelsen RB, Schmidt-Ullrich RK. Epidermal growth factor receptor as a genetic therapy target for carcinoma cell radiosensitization. Journal of the National Cancer Institute. 93: 921-9. PMID 11416113 DOI: 10.1093/Jnci/93.12.921  0.424
2001 Yu C, Wang S, Dent P, Grant S. Sequence-dependent potentiation of paclitaxel-mediated apoptosis in human leukemia cells by inhibitors of the mitogen-activated protein kinase kinase/mitogen-activated protein kinase pathway. Molecular Pharmacology. 60: 143-54. PMID 11408609 DOI: 10.1124/Mol.60.1.143  0.468
2001 Dent P, Logsdon C, Nicke B, Valerie K, Farnsworth J, Schmidt-Ullrich R, Reardon DB. Recombinant adenoviral expression of dominant-negative Ras N17 blocking radiation-induced activation of mitogen-activated protein kinase pathway. Methods in Enzymology. 333: 28-37. PMID 11400343 DOI: 10.1016/S0076-6879(01)33041-0  0.427
2001 Bowers G, Reardon D, Hewitt T, Dent P, Mikkelsen RB, Valerie K, Lammering G, Amir C, Schmidt-Ullrich RK. The relative role of ErbB1-4 receptor tyrosine kinases in radiation signal transduction responses of human carcinoma cells Oncogene. 20: 1388-1397. PMID 11313882 DOI: 10.1038/Sj.Onc.1204255  0.444
2001 Dent P, Grant S. Pharmacologic interruption of the mitogen-activated extracellular-regulated kinase/mitogen-activated protein kinase signal transduction pathway: Potential role in promoting cytotoxic drug action Clinical Cancer Research. 7: 775-783. PMID 11309321  0.405
2001 Kinoshita I, Leaner V, Katabami M, Hendricks D, Manzano R, Bell A, Dent P, Birrer M. Identification of genes regulated by AP-1 in Rat-1a cells expressing inducible cJun Nature Genetics. 27: 64-64. DOI: 10.1038/87152  0.32
2001 Lammering G, Hewit T, Contessa J, Hawkins W, Lin P, Valerie K, Mikkelsen R, Dent P, Schmidt-Ullrich R. EGFR and its mutant EGFRvIII as modulators of tumor cell radiosensitivity International Journal of Radiation Oncology*Biology*Physics. 51: 103. DOI: 10.1016/S0360-3016(01)02012-0  0.52
2000 Tang L, Boise LH, Dent P, Grant S. Potentiation of 1-β-D-arabinofuranosylcytosine-mediated mitochondrial damage and apoptosis in human leukemia cells (U937) overexpressing Bcl-2 by the kinase inhibitor 7-hydroxystaurosporine (UCN-01) Biochemical Pharmacology. 60: 1445-1456. PMID 11020446 DOI: 10.1016/S0006-2952(00)00463-9  0.475
2000 Wang Z, Wang S, Fisher PB, Dent P, Grant S. Evidence of a functional role for the cyclin-dependent kinase inhibitor p21CIP1 in leukemic cell (U937) differentiation induced by low concentrations of 1-beta-D-arabinofuranosylcytosine. Differentiation; Research in Biological Diversity. 66: 1-13. PMID 10997587 DOI: 10.1046/J.1432-0436.2000.066001001.X  0.482
2000 Park JS, Qiao L, Gilfor D, Yan Yang M, Hylemon PB, Benz C, Darlington G, Firestone G, Fisher PB, Dent P. A role for both ets and C/EBP transcription factors and mRNA stabilization in the MAPK-dependent increase in p21 Cip-1/WAF1/mda6 protein levels in primary hepatocytes Molecular Biology of the Cell. 11: 2915-2932. PMID 10982390 DOI: 10.1091/Mbc.11.9.2915  0.376
2000 Madireddi MT, Dent P, Fisher PB. AP-1 and C/EBP transcription factors contribute to mda-7 gene promoter activity during human melanoma differentiation. Journal of Cellular Physiology. 185: 36-46. PMID 10942517 DOI: 10.1002/1097-4652(200010)185:1<36::Aid-Jcp3>3.0.Co;2-V  0.404
2000 Spector M, Nguyen VA, Sheng X, He L, Woodward J, Fan S, Baumgarten CM, Kunos G, Dent P, Gao B. Activation of mitogen-activated protein kinases is required for alpha1-adrenergic agonist-induced cell scattering in transfected HepG2 cells. Experimental Cell Research. 258: 109-20. PMID 10912793 DOI: 10.1006/Excr.2000.4907  0.472
2000 Bondzi C, Litz J, Dent P, Krystal GW. Src family kinase activity is required for Kit-mediated mitogen-activated protein (MAP) kinase activation, however loss of functional retinoblastoma protein makes MAP kinase activation unnecessary for growth of small cell lung cancer cells. Cell Growth & Differentiation : the Molecular Biology Journal of the American Association For Cancer Research. 11: 305-14. PMID 10910097  0.323
2000 Hagan M, Wang L, Hanley JR, Park JS, Dent P. Ionizing radiation-induced mitogen-activated protein (MAP) kinase activation in DU145 prostate carcinoma cells: MAP kinase inhibition enhances radiation-induced cell killing and G2/M-phase arrest. Radiation Research. 153: 371-83. PMID 10760996 DOI: 10.1667/0033-7587(2000)153[0371:Irimap]2.0.Co;2  0.475
2000 Madireddi MT, Dent P, Fisher PB. Regulation of mda-7 gene expression during human melanoma differentiation. Oncogene. 19: 1362-8. PMID 10713678 DOI: 10.1038/Sj.Onc.1203424  0.42
2000 Schmidt-Ullrich RK, Dent P, Grant S, Mikkelsen RB, Valerie K. Signal transduction and cellular radiation responses Radiation Research. 153: 245-257. PMID 10669545 DOI: 10.1667/0033-7587(2000)153[0245:Stacrr]2.0.Co;2  0.42
2000 Park JS, Boyer S, Mitchell K, Gilfor D, Birrer M, Darlington G, El Deiry W, Firestone GL, Munger K, Band V, Fisher PB, Dent P. Expression of human papilloma virus E7 protein causes apoptosis and inhibits DNA synthesis in primary hepatocytes via increased expression of p21(Cip-1/WAF1/MDA6). The Journal of Biological Chemistry. 275: 18-28. PMID 10617580 DOI: 10.1074/Jbc.275.1.18  0.349
2000 Cartee L, Vrana JA, Wang Z, Park JS, Birrer M, Fisher PB, Grant S, Dent P. Inhibition of the mitogen activated protein kinase pathway potentiates radiation-induced cell killing via cell cycle arrest at the G2/M transition and independently of increased signaling by the JNK/c-Jun pathway. International Journal of Oncology. 16: 413-435. DOI: 10.3892/Ijo.16.2.413  0.514
2000 Gupta S, Stravitz RT, Dent P, Vlahcevic ZR, Hylemon PB. Bile acid induced signal transductive pathways involved in regulation of cholesterol 7a-hydroxylase(CYP7a1) transcription Gastroenterology. 118: A2. DOI: 10.1016/S0016-5085(00)82073-9  0.381
1999 Park JS, Carter S, Reardon DB, Schmidt-Ullrich R, Dent P, Fisher PB. Roles for basal and stimulated p21(Cip-1/WAF1/MDA6) expression and mitogen-activated protein kinase signaling in radiation-induced cell cycle checkpoint control in carcinoma cells Molecular Biology of the Cell. 10: 4231-4246. PMID 10588655 DOI: 10.1091/Mbc.10.12.4231  0.479
1999 Taher MM, Baumgardner T, Dent P, Valerie K. Genetic evidence that stress-activated p38 MAP kinase is necessary but not sufficient for UV activation of HIV gene expression Biochemistry. 38: 13055-13062. PMID 10529175 DOI: 10.1021/Bi9902900  0.331
1999 Reardon DB, Contessa JN, Mikkelsen RB, Valerie K, Amir C, Dent P, Schmidt-Ullrich RK. Dominant negative EGFR-CD533 and inhibition of MAPK modify JNK1 activation and enhance radiation toxicity of human mammary carcinoma cells. Oncogene. 18: 4756-66. PMID 10467423 DOI: 10.1038/Sj.Onc.1202849  0.471
1999 Dent P, Reardon DB, Park JS, Bowers G, Logsdon C, Valerie K, Schmidt-Ullrich R. Radiation-induced release of transforming growth factor α activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation-induced cell death Molecular Biology of the Cell. 10: 2493-2506. PMID 10436007 DOI: 10.1091/Mbc.10.8.2493  0.474
1999 Vrana JA, Kramer LB, Saunders AM, Zhang XF, Dent P, Povirk LF, Grant S. Inhibition of protein kinase C activator-mediated induction of p21CIP1 and p27KIP1 by deoxycytidine analogs in human leukemia cells: relationship to apoptosis and differentiation. Biochemical Pharmacology. 58: 121-31. PMID 10403525 DOI: 10.1016/S0006-2952(99)00077-5  0.505
1999 Wang S, Wang Z, Boise L, Dent P, Grant S. Loss of the bcl-2 phosphorylation loop domain increases resistance of human leukemia cells (U937) to paclitaxel-mediated mitochondrial dysfunction and apoptosis. Biochemical and Biophysical Research Communications. 259: 67-72. PMID 10334917 DOI: 10.1006/Bbrc.1999.0669  0.456
1999 Vrana JA, Grant S, Dent P. Inhibition of the MAPK pathway abrogates BCL2-mediated survival of leukemia cells after exposure to low-dose ionizing radiation Radiation Research. 151: 559-569. PMID 10319729 DOI: 10.2307/3580032  0.504
1999 Smith RD, Baukal AJ, Dent P, Catt KJ. Raf-1 kinase activation by angiotensin II in adrenal glomerulosa cells: roles of Gi, phosphatidylinositol 3-kinase, and Ca2+ influx. Endocrinology. 140: 1385-91. PMID 10067866 DOI: 10.1210/Endo.140.3.6600  0.369
1999 Hagan M, Wang L, Hanley J, Park J, Dent P. 2052 Ionizing radiation induced mitogen activated protein (MAP) kinase activation in DU145 prostate carcinoma cells: MAP kinase inhibition enhances radiation-induced cell killing and G2/M arrest International Journal of Radiation Oncology*Biology*Physics. 45: 304. DOI: 10.1016/S0360-3016(99)90322-X  0.442
1999 Schmidt-ullrich R, Bowers G, Dent P, Reardon D, Contessa J, Valerie K. 29 ERBB receptor tyrosine kinases as determinants of cytoprotective and cytotoxic radiation responses of carcinoma cells International Journal of Radiation Oncology*Biology*Physics. 45: 161-162. DOI: 10.1016/S0360-3016(99)90047-0  0.368
1998 Dent P, Jarvis WD, Birrer MJ, Fisher PB, Schmidt-Ullrich RK, Grant S. The roles of signaling by the p42/p44 mitogen-activated protein (MAP) kinase pathway; A potential route to radio- and chemo-sensitization of tumor cells resulting in the induction of apoptosis and loss of clonogenicity Leukemia. 12: 1843-1850. PMID 9844914 DOI: 10.1038/Sj.Leu.2401222  0.467
1998 Auer KL, Park JS, Seth P, Coffey RJ, Darlington G, Abo A, McMahon M, Depinho RA, Fisher PB, Dent P. Prolonged activation of the mitogen-activated protein kinase pathway promotes DNA synthesis in primary hepatocytes from p21Cip-1/WAF1-null mice, but not in hepatocytes from p16INK4a-null mice. The Biochemical Journal. 336: 551-60. PMID 9841865 DOI: 10.1042/Bj3360551  0.387
1998 Wang S, Guo CY, Castillo A, Dent P, Grant S. Effect of bryostatin 1 on taxol-induced apoptosis and cytotoxicity in human leukemia cells (U937). Biochemical Pharmacology. 56: 635-44. PMID 9783732 DOI: 10.1016/S0006-2952(98)00188-9  0.539
1998 Auer KL, Spector MS, Tombes RM, Seth P, Fisher PB, Gao B, Dent P, Kunos G. α-Adrenergic inhibition of proliferation in HepG2 cells stably transfected with the α(1B)-adrenergic receptor through a p42(MAP kinase)/p21(Cip1/WAF1)-dependent pathway Febs Letters. 436: 131-138. PMID 9771908 DOI: 10.1016/S0014-5793(98)01074-6  0.431
1998 Chen J, Ishac EJN, Dent P, Kunos G, Gao B. Effects of ethanol on mitogen-activated protein kinase and stress-activated protein kinase cascades in normal and regenerating liver Biochemical Journal. 334: 669-676. PMID 9729476 DOI: 10.1042/Bj3340669  0.367
1998 Carter S, Auer KL, Reardon DB, Birrer M, Fisher PB, Valerie K, Schmidt-Ullrich R, Mikkelsen R, Dent P. Inhibition of the mitogen activated protein (MAP) kinase cascade potentiates cell killing by low dose ionizing radiation in A431 human squamous carcinoma cells Oncogene. 16: 2787-2796. PMID 9652746 DOI: 10.1038/Sj.Onc.1201802  0.428
1998 Kavanagh BD, Dent P, Schmidt-Ullrich RK, Chen P, Mikkelsen RB. Calcium-dependent stimulation of mitogen-activated protein kinase activity in A431 cells by low doses of ionizing radiation Radiation Research. 149: 579-587. PMID 9611096 DOI: 10.2307/3579904  0.408
1998 Tombes RM, Auer KL, Mikkelsen R, Valerie K, Wymann MP, Marshall CJ, McMahon M, Dent P. The mitogen-activated protein (MAP) kinase cascade can either stimulate or inhibit DNA synthesis in primary cultures of rat hepatocytes depending upon whether its activation is acute/phasic or chronic Biochemical Journal. 330: 1451-1460. PMID 9494119 DOI: 10.1042/Bj3301451  0.409
1998 Auer KL, Contessa J, Brenz-Verca S, Pirola L, Rusconi S, Cooper G, Abo A, Wymann MP, Davis RJ, Birrer M, Dent P. The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes. Molecular Biology of the Cell. 9: 561-73. PMID 9487126 DOI: 10.1091/Mbc.9.3.561  0.364
1998 JARVIS WD, FORNARI FA, BIRRER MJ, FREEMERMAN AJ, AUER KL, DENT P, GRANT S. Coordinate Regulation of Stress-activated Protein Kinase and Mitogen-activated Protein Kinase Cascades in the Apoptotic Actions of Ceramide and Sphingosine Annals of the New York Academy of Sciences. 845: 413-413. DOI: 10.1111/J.1749-6632.1998.Tb09703.X  0.37
1997 Wang S, Vrana JA, Bartimole TM, Freemerman AJ, Jarvis WD, Kramer LB, Krystal G, Dent P, Grant S. Agents that down-regulate or inhibit protein kinase C circumvent resistance to 1-beta-D-arabinofuranosylcytosine-induced apoptosis in human leukemia cells that overexpress Bcl-2. Molecular Pharmacology. 52: 1000-9. PMID 9396780 DOI: 10.1124/Mol.52.6.1000  0.513
1997 Schmidt-Ullrich RK, Mikkelsen RB, Dent P, Todd DG, Valerie K, Kavanagh BD, Contessa JN, Rorrer WK, Chen PB. Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation. Oncogene. 15: 1191-7. PMID 9294612 DOI: 10.1038/Sj.Onc.1201275  0.455
1997 Jarvis WD, Auer KL, Spector M, Kunos G, Grant S, Hylemon P, Mikkelsen R, Dent P. Positive and negative regulation of JNK1 by protein kinase C and p42(MAP kinase) in adult rat hepatocytes. Febs Letters. 412: 9-14. PMID 9257680 DOI: 10.1016/S0014-5793(97)00705-9  0.443
1997 Stancato LF, Sakatsume M, David M, Dent P, Dong F, Petricoin EF, Krolewski JJ, Silvennoinen O, Saharinen P, Pierce J, Marshall CJ, Sturgill T, Finbloom DS, Larner AC. Beta interferon and oncostatin M activate Raf-1 and mitogen-activated protein kinase through a JAK1-dependent pathway. Molecular and Cellular Biology. 17: 3833-3840. PMID 9199317 DOI: 10.1128/Mcb.17.7.3833  0.45
1997 Spector MS, Auer KL, Jarvis WD, Ishac EJN, Gao B, Kunos G, Dent P. Differential regulation of the mitogen-activated protein and stress-activated protein kinase cascades by adrenergic agonists in quiescent and regenerating adult rat hepatocytes. Molecular and Cellular Biology. 17: 3556-3565. PMID 9199291 DOI: 10.1128/Mcb.17.7.3556  0.407
1993 Dent P, Wu J, Romero G, Vincent LA, Castle D, Sturgill TW. Activation of the mitogen-activated protein kinase pathway in Triton X- 100 disrupted NIH-3T3 cells by p21 ras and in vitro by plasma membranes from NIH 3T3 cells Molecular Biology of the Cell. 4: 483-493. PMID 8334304 DOI: 10.1091/Mbc.4.5.483  0.313
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