| Year |
Citation |
Score |
| 2020 |
Probst A, Häberli C, Siegel D, Huang J, Vigneron S, Ta AP, Skinner DE, El-Sakkary N, Momper JD, Gangoiti J, Dong Y, Vennerstrom JL, Charman SA, Caffrey CR, Keiser J. Efficacy, metabolism and pharmacokinetics of Ro 15-5458, a forgotten schistosomicidal 9-acridanone hydrazone. The Journal of Antimicrobial Chemotherapy. PMID 32617557 DOI: 10.1093/Jac/Dkaa247 |
0.302 |
|
| 2020 |
Wu J, Wang X, Chiu FCK, Häberli C, Shackleford DM, Ryan E, Kamaraj S, Bulbule VJ, Wallick AI, Dong Y, White KL, Davis PH, Charman SA, Keiser J, Vennerstrom JL. Structure–ActivityRelationship of AntischistosomalOzonide Carboxylic Acids Journal of Medicinal Chemistry. DOI: 10.1021/Acs.Jmedchem.0C00069.S001 |
0.374 |
|
| 2019 |
Giannangelo C, Anderson D, Wang X, Vennerstrom JL, Charman SA, Creek DJ. Ozonide antimalarials alkylate heme in the malaria parasite Plasmodium falciparum. Acs Infectious Diseases. PMID 31622078 DOI: 10.1021/Acsinfecdis.9B00257 |
0.334 |
|
| 2018 |
Sanford AG, Schulze TT, Potluri LP, Watson GF, Darner EB, Zach SJ, Hemsley RM, Wallick AI, Warner RC, Charman SA, Wang X, Vennerstrom JL, Davis PH. Derivatives of a benzoquinone acyl hydrazone with activity against Toxoplasma gondii. International Journal For Parasitology. Drugs and Drug Resistance. 8: 488-492. PMID 30500526 DOI: 10.1016/J.Ijpddr.2018.11.001 |
0.349 |
|
| 2018 |
Wu J, Wang C, Häberli C, White KL, Shackleford DM, Chen G, Dong Y, Charman SA, Keiser J, Vennerstrom JL. SAR of a new antischistosomal urea carboxylic acid. Bioorganic & Medicinal Chemistry Letters. PMID 30389288 DOI: 10.1016/J.Bmcl.2018.10.039 |
0.373 |
|
| 2018 |
Wang Y, Mukhopadhyay R, Roy S, Kapoor A, Su YP, Charman SA, Chen G, Wu J, Wang X, Vennerstrom JL, Arav-Boger R. Inhibition of Cytomegalovirus Replication with Extended Half-Life Synthetic Ozonides. Antimicrobial Agents and Chemotherapy. PMID 30373792 DOI: 10.1128/Aac.01735-18 |
0.315 |
|
| 2017 |
Sanford AG, Schulze TT, Potluri LP, Hemsley RM, Larson JJ, Judge AK, Zach SJ, Wang X, Charman SA, Vennerstrom JL, Davis PH. Novel Toxoplasma gondii inhibitor chemotypes. Parasitology International. PMID 29081387 DOI: 10.1016/J.Parint.2017.10.010 |
0.351 |
|
| 2017 |
Dong Y, Wang X, Kamaraj S, Bulbule VJ, Chiu FC, Chollet J, Manickam D, Hein CD, Papastogiannidis P, Morizzi J, Shackleford DM, Barker H, Ryan E, Scheurer C, Tang Y, ... ... Vennerstrom JL, et al. SAR of the Antimalarial Ozonide Artefenomel (OZ439). Journal of Medicinal Chemistry. PMID 28052200 DOI: 10.1021/Acs.Jmedchem.6B01586 |
0.307 |
|
| 2016 |
Wang C, Zhao Q, Vargas M, Jones JO, White KL, Shackleford DM, Chen G, Saunders J, Ng AC, Chiu FC, Dong Y, Charman SA, Keiser J, Vennerstrom JL. Revisiting the SAR of the Antischistosomal Aryl Hydantoin (Ro 13-3978). Journal of Medicinal Chemistry. 59: 10705-10718. PMID 27933964 DOI: 10.1021/Acs.Jmedchem.6B01410 |
0.384 |
|
| 2016 |
McFarland MM, Zach SJ, Wang X, Potluri LP, Neville AJ, Vennerstrom JL, Davis PH. A Review of Experimental Compounds Demonstrating Anti-Toxoplasma Activity. Antimicrobial Agents and Chemotherapy. PMID 27600037 DOI: 10.1128/Aac.01176-16 |
0.322 |
|
| 2015 |
Wang X, Dong Y, Cal M, Kaiser M, Wittlin S, Vennerstrom JL. Antiprotozoal Selectivity of Diimidazoline N-Phenylbenzamides. Acs Infectious Diseases. 1: 135-9. PMID 27622464 DOI: 10.1021/Id500034V |
0.308 |
|
| 2015 |
Cowan N, Dätwyler P, Ernst B, Wang C, Vennerstrom JL, Spangenberg T, Keiser J. Activities of N,N'-Diarylurea MMV665852 analogs against Schistosoma mansoni. Antimicrobial Agents and Chemotherapy. 59: 1935-41. PMID 25583726 DOI: 10.1128/Aac.04463-14 |
0.375 |
|
| 2015 |
Coulter DW, Vennerstrom J, Sharp JG, Dong Y, Wang X, McIntyre E, McGuire T. Abstract 4362: Screening of investigational antimalarials for anticancer activity in high risk N-MYC amplified neuroblastoma (NB) Cancer Research. 75: 4362-4362. DOI: 10.1158/1538-7445.Am2015-4362 |
0.341 |
|
| 2014 |
Wang C, Zhao Q, Min J, Muniyan S, Vargas M, Wang X, Dong Y, Guy RK, Lin MF, Keiser J, Vennerstrom JL. Antischistosomal versus antiandrogenic properties of aryl hydantoin Ro 13-3978. The American Journal of Tropical Medicine and Hygiene. 90: 1156-8. PMID 24686741 DOI: 10.4269/Ajtmh.14-0029 |
0.302 |
|
| 2014 |
Dong Y, Wang X, Cal M, Kaiser M, Vennerstrom JL. Activity of diimidazoline amides against African trypanosomiasis. Bioorganic & Medicinal Chemistry Letters. 24: 944-8. PMID 24398295 DOI: 10.1016/J.Bmcl.2013.12.064 |
0.33 |
|
| 2014 |
Küster T, Kriegel N, Stadelmann B, Wang X, Dong Y, Vennerstrom JL, Keiser J, Hemphill A. Amino ozonides exhibit in vitro activity against Echinococcus multilocularis metacestodes. International Journal of Antimicrobial Agents. 43: 40-6. PMID 24239405 DOI: 10.1016/J.Ijantimicag.2013.09.012 |
0.34 |
|
| 2013 |
Wang X, Dong Y, Wittlin S, Charman SA, Chiu FC, Chollet J, Katneni K, Mannila J, Morizzi J, Ryan E, Scheurer C, Steuten J, Santo Tomas J, Snyder C, Vennerstrom JL. Comparative antimalarial activities and ADME profiles of ozonides (1,2,4-trioxolanes) OZ277, OZ439, and their 1,2-dioxolane, 1,2,4-trioxane, and 1,2,4,5-tetraoxane isosteres. Journal of Medicinal Chemistry. 56: 2547-55. PMID 23489135 DOI: 10.1021/Jm400004U |
0.346 |
|
| 2012 |
Sabbah DA, Vennerstrom JL, Zhong HA. Binding selectivity studies of phosphoinositide 3-kinases using free energy calculations. Journal of Chemical Information and Modeling. 52: 3213-24. PMID 23157418 DOI: 10.1021/Ci3003057 |
0.618 |
|
| 2012 |
Sabbah DA, Simms NA, Wang W, Dong Y, Ezell EL, Brattain MG, Vennerstrom JL, Zhong HA. N-Phenyl-4-hydroxy-2-quinolone-3-carboxamides as selective inhibitors of mutant H1047R phosphoinositide-3-kinase (PI3Kα). Bioorganic & Medicinal Chemistry. 20: 7175-83. PMID 23121722 DOI: 10.1016/J.Bmc.2012.09.059 |
0.63 |
|
| 2012 |
Sabbah DA, Simms NA, Brattain MG, Vennerstrom JL, Zhong H. Biological evaluation and docking studies of recently identified inhibitors of phosphoinositide-3-kinases. Bioorganic & Medicinal Chemistry Letters. 22: 876-80. PMID 22212721 DOI: 10.1016/J.Bmcl.2011.12.044 |
0.636 |
|
| 2012 |
Keiser J, Ingram K, Vargas M, Chollet J, Wang X, Dong Y, Vennerstrom JL. In vivo activity of aryl ozonides against Schistosoma species. Antimicrobial Agents and Chemotherapy. 56: 1090-2. PMID 22106214 DOI: 10.1128/Aac.05371-11 |
0.351 |
|
| 2011 |
Kirchhofer C, Vargas M, Braissant O, Dong Y, Wang X, Vennerstrom JL, Keiser J. Activity of OZ78 analogues against Fasciola hepatica and Echinostoma caproni. Acta Tropica. 118: 56-62. PMID 21316331 DOI: 10.1016/J.Actatropica.2011.02.003 |
0.304 |
|
| 2011 |
Charman SA, Arbe-Barnes S, Bathurst IC, Brun R, Campbell M, Charman WN, Chiu FC, Chollet J, Craft JC, Creek DJ, Dong Y, Matile H, Maurer M, Morizzi J, Nguyen T, ... ... Vennerstrom JL, et al. Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria. Proceedings of the National Academy of Sciences of the United States of America. 108: 4400-5. PMID 21300861 DOI: 10.1073/Pnas.1015762108 |
0.341 |
|
| 2010 |
Gufford BT, Sriraghavan K, Miller NJ, Miller DW, Gu X, Vennerstrom JL, Robinson DH. Physicochemical characterization of creatine N-methylguanidinium salts. Journal of Dietary Supplements. 7: 240-52. PMID 22432515 DOI: 10.3109/19390211.2010.491507 |
0.31 |
|
| 2010 |
Flaherty DP, Kiyota T, Dong Y, Ikezu T, Vennerstrom JL. Phenolic bis-styrylbenzenes as β-amyloid binding ligands and free radical scavengers. Journal of Medicinal Chemistry. 53: 7992-9. PMID 21038854 DOI: 10.1021/Jm1006929 |
0.666 |
|
| 2010 |
Dong Y, McCullough KJ, Wittlin S, Chollet J, Vennerstrom JL. The structure and antimalarial activity of dispiro-1,2,4,5-tetraoxanes derived from (+)-dihydrocarvone Bioorganic and Medicinal Chemistry Letters. 20: 6359-6361. PMID 20943385 DOI: 10.1016/J.Bmcl.2010.09.113 |
0.313 |
|
| 2010 |
Sabbah DA, Vennerstrom JL, Zhong H. Docking studies on isoform-specific inhibition of phosphoinositide-3-kinases. Journal of Chemical Information and Modeling. 50: 1887-98. PMID 20866085 DOI: 10.1021/Ci1002679 |
0.633 |
|
| 2010 |
Longo M, Zanoncelli S, Brughera M, Colombo P, Wittlin S, Vennerstrom JL, Moehrle J, Craft JC. Comparative embryotoxicity of different antimalarial peroxides: in vitro study using the rat whole embryo culture model (WEC). Reproductive Toxicology (Elmsford, N.Y.). 30: 583-90. PMID 20708075 DOI: 10.1016/J.Reprotox.2010.07.011 |
0.334 |
|
| 2010 |
Zhao Q, Vargas M, Dong Y, Zhou L, Wang X, Sriraghavan K, Keiser J, Vennerstrom JL. Structure-activity relationship of an ozonide carboxylic acid (OZ78) against Fasciola hepatica. Journal of Medicinal Chemistry. 53: 4223-33. PMID 20423101 DOI: 10.1021/Jm100226T |
0.357 |
|
| 2010 |
Dong Y, Chollet J, Vargas M, Mansour NR, Bickle Q, Alnouti Y, Huang J, Keiser J, Vennerstrom JL. Praziquantel analogs with activity against juvenile Schistosoma mansoni. Bioorganic & Medicinal Chemistry Letters. 20: 2481-4. PMID 20303754 DOI: 10.1016/J.Bmcl.2010.03.001 |
0.312 |
|
| 2010 |
Fügi MA, Wittlin S, Dong Y, Vennerstrom JL. Probing the antimalarial mechanism of artemisinin and OZ277 (arterolane) with nonperoxidic isosteres and nitroxyl radicals. Antimicrobial Agents and Chemotherapy. 54: 1042-6. PMID 20028825 DOI: 10.1128/Aac.01305-09 |
0.339 |
|
| 2010 |
Tang Y, Wittlin S, Charman SA, Chollet J, Chiu FC, Morizzi J, Johnson LM, Tomas JS, Scheurer C, Snyder C, Zhou L, Dong Y, Charman WN, Matile H, Urwyler H, ... ... Vennerstrom JL, et al. The comparative antimalarial properties of weak base and neutral synthetic ozonides. Bioorganic & Medicinal Chemistry Letters. 20: 563-6. PMID 19962893 DOI: 10.1016/J.Bmcl.2009.11.088 |
0.332 |
|
| 2010 |
Dong Y, Wittlin S, Sriraghavan K, Chollet J, Charman SA, Charman WN, Scheurer C, Urwyler H, Santo Tomas J, Snyder C, Creek DJ, Morizzi J, Koltun M, Matile H, Wang X, ... ... Vennerstrom JL, et al. The structure-activity relationship of the antimalarial ozonide arterolane (OZ277). Journal of Medicinal Chemistry. 53: 481-91. PMID 19924861 DOI: 10.1021/Jm901473S |
0.357 |
|
| 2009 |
Wang X, Creek DJ, Schiaffo CE, Dong Y, Chollet J, Scheurer C, Wittlin S, Charman SA, Dussault PH, Wood JK, Vennerstrom JL. Spiroadamantyl 1,2,4-trioxolane, 1,2,4-trioxane, and 1,2,4-trioxepane pairs: relationship between peroxide bond iron(II) reactivity, heme alkylation efficiency, and antimalarial activity. Bioorganic & Medicinal Chemistry Letters. 19: 4542-5. PMID 19616946 DOI: 10.1016/J.Bmcl.2009.07.013 |
0.3 |
|
| 2009 |
Creek DJ, Ryan E, Charman WN, Chiu FC, Prankerd RJ, Vennerstrom JL, Charman SA. Stability of peroxide antimalarials in the presence of human hemoglobin. Antimicrobial Agents and Chemotherapy. 53: 3496-500. PMID 19487440 DOI: 10.1128/Aac.00363-09 |
0.317 |
|
| 2008 |
Hermone AR, Burnett JC, Nuss JE, Tressler LE, Nguyen TL, Solaja BA, Vennerstrom JL, Schmidt JJ, Wipf P, Bavari S, Gussio R. Three-dimensional database mining identifies a unique chemotype that unites structurally diverse botulinum neurotoxin serotype A inhibitors in a three-zone pharmacophore. Chemmedchem. 3: 1905-12. PMID 19006141 DOI: 10.1002/Cmdc.200800241 |
0.348 |
|
| 2008 |
Creek DJ, Charman WN, Chiu FC, Prankerd RJ, Dong Y, Vennerstrom JL, Charman SA. Relationship between antimalarial activity and heme alkylation for spiro- and dispiro-1,2,4-trioxolane antimalarials. Antimicrobial Agents and Chemotherapy. 52: 1291-6. PMID 18268087 DOI: 10.1128/Aac.01033-07 |
0.315 |
|
| 2007 |
Flaherty DP, Walsh SM, Kiyota T, Dong Y, Ikezu T, Vennerstrom JL. Polyfluorinated bis-styrylbenzene beta-amyloid plaque binding ligands. Journal of Medicinal Chemistry. 50: 4986-92. PMID 17845017 DOI: 10.1021/Jm070085F |
0.647 |
|
| 2007 |
Kaiser M, Wittlin S, Nehrbass-Stuedli A, Dong Y, Wang X, Hemphill A, Matile H, Brun R, Vennerstrom JL. Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160). Antimicrobial Agents and Chemotherapy. 51: 2991-3. PMID 17562801 DOI: 10.1128/Aac.00225-07 |
0.322 |
|
| 2007 |
Creek DJ, Charman WN, Chiu FCK, Prankerd RJ, McCullough KJ, Dong Y, Vennerstrom JL, Charman SA. Iron-mediated degradation kinetics of substituted dispiro-1,2,4-trioxolane antimalarials Journal of Pharmaceutical Sciences. 96: 2945-2956. PMID 17549767 DOI: 10.1002/Jps.20958 |
0.305 |
|
| 2007 |
Dong Y, Creek D, Chollet J, Matile H, Charman SA, Wittlin S, Wood JK, Vennerstrom JL. Comparative antimalarial activities of six pairs of 1,2,4,5-tetraoxanes (peroxide dimers) and 1,2,4,5,7,8-hexaoxonanes (peroxide trimers). Antimicrobial Agents and Chemotherapy. 51: 3033-5. PMID 17485500 DOI: 10.1128/Aac.00264-07 |
0.303 |
|
| 2007 |
Burnett JC, Opsenica D, Sriraghavan K, Panchal RG, Ruthel G, Hermone AR, Nguyen TL, Kenny TA, Lane DJ, McGrath CF, Schmidt JJ, Vennerstrom JL, Gussio R, Solaja BA, Bavari S. A refined pharmacophore identifies potent 4-amino-7-chloroquinoline-based inhibitors of the botulinum neurotoxin serotype A metalloprotease. Journal of Medicinal Chemistry. 50: 2127-36. PMID 17417831 DOI: 10.1021/Jm061446E |
0.362 |
|
| 2007 |
Xiao SH, Keiser J, Chollet J, Utzinger J, Dong Y, Endriss Y, Vennerstrom JL, Tanner M. In vitro and in vivo activities of synthetic trioxolanes against major human schistosome species. Antimicrobial Agents and Chemotherapy. 51: 1440-5. PMID 17283188 DOI: 10.1128/Aac.01537-06 |
0.324 |
|
| 2006 |
Padmanilayam M, Scorneaux B, Dong Y, Chollet J, Matile H, Charman SA, Creek DJ, Charman WN, Tomas JS, Scheurer C, Wittlin S, Brun R, Vennerstrom JL. Antimalarial activity of N-alkyl amine, carboxamide, sulfonamide, and urea derivatives of a dispiro-1,2,4-trioxolane piperidine. Bioorganic & Medicinal Chemistry Letters. 16: 5542-5. PMID 16931006 DOI: 10.1016/J.Bmcl.2006.08.046 |
0.373 |
|
| 2006 |
Dong Y, Tang Y, Chollet J, Matile H, Wittlin S, Charman SA, Charman WN, Tomas JS, Scheurer C, Snyder C, Scorneaux B, Bajpai S, Alexander SA, Wang X, Padmanilayam M, ... ... Vennerstrom JL, et al. Effect of functional group polarity on the antimalarial activity of spiro and dispiro-1,2,4-trioxolanes. Bioorganic & Medicinal Chemistry. 14: 6368-82. PMID 16759871 DOI: 10.1016/J.Bmc.2006.05.041 |
0.312 |
|
| 2005 |
Dong Y, Chollet J, Matile H, Charman SA, Chiu FC, Charman WN, Scorneaux B, Urwyler H, Santo Tomas J, Scheurer C, Snyder C, Dorn A, Wang X, Karle JM, Tang Y, ... ... Vennerstrom JL, et al. Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes. Journal of Medicinal Chemistry. 48: 4953-61. PMID 16033274 DOI: 10.1021/Jm049040U |
0.343 |
|
| 2005 |
Burnett JC, Schmidt JJ, McGrath CF, Nguyen TL, Hermone AR, Panchal RG, Vennerstrom JL, Kodukula K, Zaharevitz DW, Gussio R, Bavari S. Conformational sampling of the botulinum neurotoxin serotype A light chain: implications for inhibitor binding. Bioorganic & Medicinal Chemistry. 13: 333-41. PMID 15598556 DOI: 10.1016/J.Bmc.2004.10.026 |
0.353 |
|
| 2004 |
Vennerstrom JL, Arbe-Barnes S, Brun R, Charman SA, Chiu FC, Chollet J, Dong Y, Dorn A, Hunziker D, Matile H, McIntosh K, Padmanilayam M, Santo Tomas J, Scheurer C, Scorneaux B, et al. Identification of an antimalarial synthetic trioxolane drug development candidate. Nature. 430: 900-4. PMID 15318224 DOI: 10.1038/Nature02779 |
0.328 |
|
| 2004 |
Becker K, Tilley L, Vennerstrom JL, Roberts D, Rogerson S, Ginsburg H. Oxidative stress in malaria parasite-infected erythrocytes: host-parasite interactions. International Journal For Parasitology. 34: 163-89. PMID 15037104 DOI: 10.1016/J.Ijpara.2003.09.011 |
0.308 |
|
| 2003 |
Dong Y, Vennerstrom JL. Mechanisms of in situ activation for peroxidic antimalarials. Redox Report : Communications in Free Radical Research. 8: 284-8. PMID 14962366 DOI: 10.1179/135100003225002989 |
0.309 |
|
| 2003 |
Burnett JC, Schmidt JJ, Stafford RG, Panchal RG, Nguyen TL, Hermone AR, Vennerstrom JL, McGrath CF, Lane DJ, Sausville EA, Zaharevitz DW, Gussio R, Bavari S. Novel small molecule inhibitors of botulinum neurotoxin A metalloprotease activity. Biochemical and Biophysical Research Communications. 310: 84-93. PMID 14511652 DOI: 10.1016/J.Bbrc.2003.08.112 |
0.368 |
|
| 2003 |
Cheruku SR, Maiti S, Dorn A, Scorneaux B, Bhattacharjee AK, Ellis WY, Vennerstrom JL. Carbon isosteres of the 4-aminopyridine substructure of chloroquine: effects on pK(a), hematin binding, inhibition of hemozoin formation, and parasite growth. Journal of Medicinal Chemistry. 46: 3166-9. PMID 12825955 DOI: 10.1021/Jm030038X |
0.342 |
|
| 2001 |
Dorn A, Scovill JP, Ellis WY, Matile H, Ridley RG, Vennerstrom JL. Short report: floxacrine analog WR 243251 inhibits hematin polymerization. The American Journal of Tropical Medicine and Hygiene. 65: 19-20. PMID 11504401 DOI: 10.4269/Ajtmh.2001.65.19 |
0.375 |
|
| 2000 |
Vennerstrom JL, Ager AL, Andersen SL, Grace JM, Wongpanich V, Angerhofer CK, Hu JK, Wesche DL. Assessment of the antimalarial potential of tetraoxane WR 148999. The American Journal of Tropical Medicine and Hygiene. 62: 573-8. PMID 11289666 DOI: 10.4269/Ajtmh.2000.62.573 |
0.334 |
|
| 2000 |
Vennerstrom JL, Dong Y, Andersen SL, Ager AL, Fu H, Miller RE, Wesche DL, Kyle DE, Gerena L, Walters SM, Wood JK, Edwards G, Holme AD, McLean WG, Milhous WK. Synthesis and antimalarial activity of sixteen dispiro-1,2,4, 5-tetraoxanes: alkyl-substituted 7,8,15,16-tetraoxadispiro[5.2.5. 2]hexadecanes. Journal of Medicinal Chemistry. 43: 2753-8. PMID 10893313 DOI: 10.1021/Jm0000766 |
0.356 |
|
| 2000 |
Vippagunta SR, Dorn A, Ridley RG, Vennerstrom JL. Characterization of chloroquine-hematin mu-oxo dimer binding by isothermal titration calorimetry. Biochimica Et Biophysica Acta. 1475: 133-40. PMID 10832027 DOI: 10.1016/S0304-4165(00)00058-1 |
0.319 |
|
| 2000 |
McCullough KJ, Wood JK, Bhattacharjee AK, Dong Y, Kyle DE, Milhous WK, Vennerstrom JL. Methyl-substituted dispiro-1,2,4,5-tetraoxanes: Correlations of structural studies with antimalarial activity Journal of Medicinal Chemistry. 43: 1246-1249. PMID 10737758 DOI: 10.1021/Jm990530+ |
0.31 |
|
| 1999 |
Vippagunta SR, Dorn A, Matile H, Bhattacharjee AK, Karle JM, Ellis WY, Ridley RG, Vennerstrom JL. Structural specificity of chloroquine-hematin binding related to inhibition of hematin polymerization and parasite growth. Journal of Medicinal Chemistry. 42: 4630-9. PMID 10579825 DOI: 10.1021/Jm9902180 |
0.379 |
|
| 1999 |
Vippagunta SR, Dorn A, Bubendorf A, Ridley RG, Vennerstrom JL. Deferoxamine: stimulation of hematin polymerization and antagonism of its inhibition by chloroquine. Biochemical Pharmacology. 58: 817-24. PMID 10449192 DOI: 10.1016/S0006-2952(99)00161-6 |
0.372 |
|
| 1999 |
Dong Y, Matile H, Chollet J, Kaminsky R, Wood JK, Vennerstrom JL. Synthesis and antimalarial activity of 11 dispiro-1,2,4,5-tetraoxane analogues of WR 148999. 7,8,15,16-tetraoxadispiro[5.2.5.2]hexadecanes substituted at the 1 and 10 positions with unsaturated and polar functional groups Journal of Medicinal Chemistry. 42: 1477-1480. PMID 10212135 DOI: 10.1021/Jm980698F |
0.357 |
|
| 1999 |
Vennerstrom JL, Nuzum EO, Miller RE, Dorn A, Gerena L, Dande PA, Ellis WY, Ridley RG, Milhous WK. 8-Aminoquinolines active against blood stage Plasmodium falciparum in vitro inhibit hematin polymerization. Antimicrobial Agents and Chemotherapy. 43: 598-602. PMID 10049273 DOI: 10.1128/Aac.43.3.598 |
0.336 |
|
| 1998 |
Vennerstrom JL, Ager AL, Dorn A, Andersen SL, Gerena L, Ridley RG, Milhous WK. Bisquinolines. 2. Antimalarial N,N-bis(7-chloroquinolin-4-yl)heteroalkanediamines. Journal of Medicinal Chemistry. 41: 4360-4. PMID 9784111 DOI: 10.1021/Jm9803828 |
0.361 |
|
| 1998 |
Dorn A, Vippagunta SR, Matile H, Bubendorf A, Vennerstrom JL, Ridley RG. A comparison and analysis of several ways to promote haematin (haem) polymerisation and an assessment of its initiation in vitro. Biochemical Pharmacology. 55: 737-47. PMID 9586945 DOI: 10.1016/S0006-2952(97)00509-1 |
0.336 |
|
| 1998 |
Dorn A, Vippagunta SR, Matile H, Jaquet C, Vennerstrom JL, Ridley RG. An assessment of drug-haematin binding as a mechanism for inhibition of haematin polymerisation by quinoline antimalarials. Biochemical Pharmacology. 55: 727-36. PMID 9586944 DOI: 10.1016/S0006-2952(97)00510-8 |
0.398 |
|
| 1995 |
Vennerstrom JL, Makler MT, Angerhofer CK, Williams JA. Antimalarial dyes revisited: Xanthenes, azines, oxazines and thiazines Antimicrobial Agents and Chemotherapy. 39: 2671-2677. PMID 8593000 DOI: 10.1128/Aac.39.12.2671 |
0.313 |
|
| 1992 |
Vennerstrom JL, Ellis WY, Ager AL, Andersen SL, Gerena L, Milhous WK. Bisquinolines. 1. N,N-bis(7-chloroquinolin-4-yl)alkanediamines with potential against chloroquine-resistant malaria Journal of Medicinal Chemistry. 35: 2129-2134. PMID 1597862 DOI: 10.1021/Jm00089A025 |
0.348 |
|
| 1992 |
Vennerstrom JL, Fu HN, Ellis WY, Ager AL, Wood JK, Andersen SL, Gerena L, Milhous WK. Dispiro-1,2,4,5-tetraoxanes: A new class of antimalarial peroxides Journal of Medicinal Chemistry. 35: 3023-3027. PMID 1501229 DOI: 10.1021/Jm00094A015 |
0.322 |
|
| 1987 |
Vennerstrom JL, Holmes TJ. Preparation and evaluation of electrophilic derivatives of phenylbutazone as inhibitors of prostaglandin-H synthase. Journal of Medicinal Chemistry. 30: 563-7. PMID 3102742 DOI: 10.1021/Jm00386A020 |
0.332 |
|
| 1987 |
Vennerstrom JL, Holmes TJ. Prostaglandin-H synthase inhibition by malonamides. Ring-opened analogues of phenylbutazone. Journal of Medicinal Chemistry. 30: 434-7. PMID 3100804 DOI: 10.1021/Jm00385A031 |
0.355 |
|
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