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Wayne C. Guida - Publications

Affiliations: 
Chemistry University of South Florida, Tampa, FL, United States 
Area:
Molecular Chemistry, Pharmacology
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63 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Jain P, Badger DB, Liang Y, Gebhard AW, Santiago D, Murray P, Kaulagari SR, Gauthier TJ, Nair R, Kumar M, Guida WC, Hazlehurst LA, McLaughlin ML. Bioactivity improvement via display of the hydrophobic core of HYD1 in a cyclic β-hairpin-like scaffold, MTI-101. Peptide Science (Hoboken, N.J.). 113: e24199. PMID 35859761 DOI: 10.1002/pep2.24199  0.751
2019 Sparks RP, Arango AS, Starr ML, Aboff ZL, Hurst LR, Rivera-Kohr DA, Zhang C, Harden KA, Jenkins JL, Guida WC, Tajkhorshid E, Fratti RA. A small-molecule competitive inhibitor of phosphatidic acid binding by the AAA+ protein NSF/Sec18 blocks the SNARE-priming stage of vacuole fusion. The Journal of Biological Chemistry. PMID 31515268 DOI: 10.1074/Jbc.Ra119.008865  0.352
2019 Binder GA, Gambino CS, Kharitonova A, Metcalf RS, Daniel KG, Guida WC. Abstract 6: Computationally assisted target screening of STING agonist for immunologic therapy Cancer Research. 79: 6-6. DOI: 10.1158/1538-7445.Am2019-6  0.332
2018 Handa S, Dempsey DR, Ramamoorthy D, Cook N, Guida WC, Spradling TJ, White JK, Woodcock HL, Merkler DJ. Mechanistic Studies of 1-Deoxy-D-Xylulose-5-Phosphate Synthase from. Biochemistry & Molecular Biology Journal. 4. PMID 29552677 DOI: 10.21767/2471-8084.100051  0.73
2018 Akuffo AA, Alontaga AY, Metcalf R, Beatty MS, Becker A, McDaniel JM, Hesterberg RS, Goodheart WE, Gunawan S, Ayaz M, Yang Y, Karim MR, Orobello ME, Daniel K, Guida W, et al. Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon. The Journal of Biological Chemistry. PMID 29449372 DOI: 10.1074/Jbc.M117.816868  0.366
2016 Mukherjee S, Sparks R, Metcalf R, Brooks W, Daniel K, Guida WC. Cupriphilic compounds to aid in proteasome inhibition. Bioorganic & Medicinal Chemistry Letters. PMID 27311892 DOI: 10.1016/J.Bmcl.2016.04.075  0.321
2015 Doupnik CA, Parra KC, Guida WC. A computational design approach for virtual screening of peptide interactions across K(+) channel families. Computational and Structural Biotechnology Journal. 13: 85-94. PMID 25709757 DOI: 10.1016/J.Csbj.2014.11.004  0.622
2015 Salm Jv, Santiago D, Wilson N, Calcul L, Kyle D, Guida W, Baker B. Targeting bioactive chemical space with a small natural products library: Expanding diversity and predictability Planta Medica. 81. DOI: 10.1055/S-0035-1556174  0.729
2014 Cross RM, Flanigan DL, Monastyrskyi A, LaCrue AN, Sáenz FE, Maignan JR, Mutka TS, White KL, Shackleford DM, Bathurst I, Fronczek FR, Wojtas L, Guida WC, Charman SA, Burrows JN, et al. Orally bioavailable 6-chloro-7-methoxy-4(1H)-quinolones efficacious against multiple stages of Plasmodium. Journal of Medicinal Chemistry. 57: 8860-79. PMID 25148516 DOI: 10.1021/Jm500942V  0.342
2014 Campbell CO, Santiago DN, Guida WC, Manetsch R, Adams JH. In silico characterization of an atypical MAPK phosphatase of Plasmodium falciparum as a suitable target for drug discovery. Chemical Biology & Drug Design. 84: 158-68. PMID 24605883 DOI: 10.1111/Cbdd.12315  0.766
2013 Urlam MK, Pireddu R, Ge Y, Zhang X, Sun Y, Lawrence HR, Guida WC, Sebti SM, Lawrence NJ. Development of new N-Arylbenzamides as STAT3 Dimerization Inhibitors. Medchemcomm. 4: 932-941. PMID 24073326 DOI: 10.1039/C3Md20323A  0.354
2013 Handa S, Ramamoorthy D, Spradling TJ, Guida WC, Adams JH, Bendinskas KG, Merkler DJ. Production of recombinant 1-deoxy-d-xylulose-5-phosphate synthase from Plasmodium vivax in Escherichia coli. Febs Open Bio. 3: 124-9. PMID 23772383 DOI: 10.1016/J.Fob.2013.01.007  0.736
2013 Ramamoorthy D, Turos E, Guida WC. Identification of a new binding site in E. coli FabH using Molecular dynamics simulations: validation by computational alanine mutagenesis and docking studies. Journal of Chemical Information and Modeling. 53: 1138-56. PMID 23581389 DOI: 10.1021/Ci3003528  0.757
2013 Ozcan S, Kazi A, Marsilio F, Fang B, Guida WC, Koomen J, Lawrence HR, Sebti SM. Oxadiazole-isopropylamides as potent and noncovalent proteasome inhibitors Journal of Medicinal Chemistry. 56: 3783-3805. PMID 23547706 DOI: 10.1021/Jm400221D  0.324
2013 Zhang X, Sun Y, Pireddu R, Yang H, Urlam MK, Lawrence HR, Guida WC, Lawrence NJ, Sebti SM. A novel inhibitor of STAT3 homodimerization selectively suppresses STAT3 activity and malignant transformation Cancer Research. 73: 1922-1933. PMID 23322008 DOI: 10.1158/0008-5472.Can-12-3175  0.308
2012 Pireddu R, Forinash KD, Sun NN, Martin MP, Sung SS, Alexander B, Zhu JY, Guida WC, Schönbrunn E, Sebti SM, Lawrence NJ. Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2). Medchemcomm. 3: 699-709. PMID 23275831 DOI: 10.1039/C2Md00320A  0.387
2012 Kim YB, Balasis ME, Doi K, Berndt N, DuBoulay C, Hu CC, Guida W, Wang HG, Sebti SM, Del Valle JR. Synthesis and evaluation of substituted hexahydronaphthalenes as novel inhibitors of the Mcl-1/BimBH3 interaction. Bioorganic & Medicinal Chemistry Letters. 22: 5961-5. PMID 22901384 DOI: 10.1016/J.Bmcl.2012.07.050  0.369
2012 Santiago DN, Pevzner Y, Durand AA, Tran M, Scheerer RR, Daniel K, Sung SS, Woodcock HL, Guida WC, Brooks WH. Virtual target screening: validation using kinase inhibitors. Journal of Chemical Information and Modeling. 52: 2192-203. PMID 22747098 DOI: 10.1021/Ci300073M  0.755
2012 Li R, Martin MP, Liu Y, Wang B, Patel RA, Zhu JY, Sun N, Pireddu R, Lawrence NJ, Li J, Haura EB, Sung SS, Guida WC, Schonbrunn E, Sebti SM. Fragment-based and structure-guided discovery and optimization of Rho kinase inhibitors. Journal of Medicinal Chemistry. 55: 2474-8. PMID 22272748 DOI: 10.1021/Jm201289R  0.351
2012 Ge Y, Kazi A, Marsilio F, Luo Y, Jain S, Brooks W, Daniel KG, Guida WC, Sebti SM, Lawrence HR. Discovery and synthesis of hydronaphthoquinones as novel proteasome inhibitors. Journal of Medicinal Chemistry. 55: 1978-98. PMID 22220566 DOI: 10.1021/Jm201118H  0.371
2012 Pireddu R, Forinash K, Sun NN, Martin MP, Sung S, Alexander B, Zhu J, Guida WC, Schönbrunn E, Sebti SM, Lawrence NJ. Abstract 3904: Pyridylthiazole-based ureas as inhibitors of Rho-associated protein kinases Cancer Research. 72: 3904-3904. DOI: 10.1158/1538-7445.Am2012-3904  0.365
2012 Ozcan S, Kazi A, Sun NN, Daniel K, Guida WC, Lawrence HR, Sebti SM. Abstract 3894: Discovery, synthesis and SAR studies of a novel nonpeptidic reversible proteosome inhibitor with low nano-molar chymotrypsin like activity Cancer Research. 72: 3894-3894. DOI: 10.1158/1538-7445.Am2012-3894  0.431
2011 Brooks WH, Guida WC, Daniel KG. The significance of chirality in drug design and development. Current Topics in Medicinal Chemistry. 11: 760-70. PMID 21291399 DOI: 10.2174/156802611795165098  0.364
2011 Scott LM, Chen L, Daniel KG, Brooks WH, Guida WC, Lawrence HR, Sebti SM, Lawrence NJ, Wu J. Shp2 protein tyrosine phosphatase inhibitor activity of estramustine phosphate and its triterpenoid analogs. Bioorganic & Medicinal Chemistry Letters. 21: 730-3. PMID 21193311 DOI: 10.1016/J.Bmcl.2010.11.117  0.43
2011 Gevariya H, Ortiz ED, Chen L, Daniel K, Lawrence HR, Guida WC, Sebti SM, Wu J, Lawrence NJ. Abstract 3248: New inhibitors of the Shp2 phosphatase Cancer Research. 71: 3248-3248. DOI: 10.1158/1538-7445.Am2011-3248  0.422
2011 Alexander BG, Pireddu R, Sun NN, Yu H, Forinash KD, Martin MP, Schonbrunn E, Guida WC, Sebti SM, Lawrence NJ. Abstract 3243: Discovery of novel Rho kinase inhibitors: Hit generation and lead optimization Cancer Research. 71: 3243-3243. DOI: 10.1158/1538-7445.Am2011-3243  0.351
2011 Pernazza D, Li X, Lawrence HR, Guida WC, DuBoulay CJ, Watts S, Sebti SM, Chen J, Lawrence NJ. Abstract 3242: New chemical tools for disrupting the MDM2/p53 protein-protein interaction: Identification, synthesis and biological evaluation of a novel class of MDM2/p53 inhibitors Cancer Research. 71: 3242-3242. DOI: 10.1158/1538-7445.Am2011-3242  0.374
2011 Scott LM, Chen L, Daniel KG, Urlam MK, Brooks WH, Guida WC, Lawrence HR, Sebti SM, Lawrence NJ, Wu J. Abstract 3239: Shp2 inhibitor activity of estramustine phosphate and its triterpenoid analogues Cancer Research. 71: 3239-3239. DOI: 10.1158/1538-7445.Am2011-3239  0.425
2011 Ge Y, Ozcan S, Kazi A, Marsilio F, Daniel K, Brooks W, Guida W, Lawrence H, Sebti S. Abstract 1362: Discovery of a novel structural class of compounds: HLM-030376 and its analogs as potent chymotrypsin-like proteasome inhibitors Cancer Research. 71: 1362-1362. DOI: 10.1158/1538-7445.Am2011-1362  0.415
2011 Ozcan S, Aslamuzzaman K, Marsilio F, Daniel K, Brooks W, Guida W, Lawrence H, Sebti S. Abstract 1359: Identification of a novel class of compounds as proteasome inhibitors: Synthesis and structure activity relationship studies of PI-1833 library Cancer Research. 71: 1359-1359. DOI: 10.1158/1538-7445.Am2011-1359  0.412
2010 Lawrence HR, Kazi A, Luo Y, Kendig R, Ge Y, Jain S, Daniel K, Santiago D, Guida WC, Sebti SM. Synthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitors. Bioorganic & Medicinal Chemistry. 18: 5576-92. PMID 20621484 DOI: 10.1016/J.Bmc.2010.06.038  0.759
2010 Chen L, Pernazza D, Scott LM, Lawrence HR, Ren Y, Luo Y, Wu X, Sung SS, Guida WC, Sebti SM, Lawrence NJ, Wu J. Inhibition of cellular Shp2 activity by a methyl ester analog of SPI-112. Biochemical Pharmacology. 80: 801-10. PMID 20510203 DOI: 10.1016/J.Bcp.2010.05.019  0.373
2010 Anderson L, Zhou M, Sharma V, McLaughlin JM, Santiago DN, Fronczek FR, Guida WC, McLaughlin ML. Facile iterative synthesis of 2,5-terpyrimidinylenes as nonpeptidic alpha-helical mimics. The Journal of Organic Chemistry. 75: 4288-91. PMID 20469918 DOI: 10.1021/Jo100272D  0.724
2010 Phan J, Li Z, Kasprzak A, Li B, Sebti S, Guida W, Schönbrunn E, Chen J. Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX. The Journal of Biological Chemistry. 285: 2174-83. PMID 19910468 DOI: 10.1074/Jbc.M109.073056  0.383
2010 Lawrence HR, Chen L, Pernazza D, Scott L, Ren Y, Luo Y, Wu X, Shen-Shu S, Guida W, Sebti SM, Lawrence NJ, Wu J. Abstract 761: The development of cell permeable Shp2 PTP inhibitors Cancer Research. 70: 761-761. DOI: 10.1158/1538-7445.Am10-761  0.434
2010 Pernazza D, Lawrence HR, Doi K, Sung S, Guida WC, Sebti SM, Wang H, Lawrence NJ. Abstract 732: Targeting the Bcl-2/BH3 protein-protein interaction: Identification, design, and synthesis of new selective inhibitors of the Mcl-1/BH3 interaction Cancer Research. 70: 732-732. DOI: 10.1158/1538-7445.Am10-732  0.419
2009 Bale S, Brooks W, Hanes JW, Mahesan AM, Guida WC, Ealick SE. Role of the sulfonium center in determining the ligand specificity of human s-adenosylmethionine decarboxylase. Biochemistry. 48: 6423-30. PMID 19527050 DOI: 10.1021/Bi900590M  0.336
2009 Kazi A, Lawrence H, Guida WC, McLaughlin ML, Springett GM, Berndt N, Yip RM, Sebti SM. Discovery of a novel proteasome inhibitor selective for cancer cells over non-transformed cells. Cell Cycle (Georgetown, Tex.). 8: 1940-51. PMID 19471122 DOI: 10.4161/Cc.8.12.8798  0.328
2009 Lawrence HR, Li Z, Yip ML, Sung SS, Lawrence NJ, McLaughlin ML, McManus GJ, Zaworotko MJ, Sebti SM, Chen J, Guida WC. Identification of a disruptor of the MDM2-p53 protein-protein interaction facilitated by high-throughput in silico docking. Bioorganic & Medicinal Chemistry Letters. 19: 3756-9. PMID 19457663 DOI: 10.1016/J.Bmcl.2009.04.124  0.386
2009 McCloskey DE, Bale S, Secrist JA, Tiwari A, Moss TH, Valiyaveettil J, Brooks WH, Guida WC, Pegg AE, Ealick SE. New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C8 substitution in structural analogues of S-adenosylmethionine. Journal of Medicinal Chemistry. 52: 1388-407. PMID 19209891 DOI: 10.1021/Jm801126A  0.407
2008 Pauly GT, Loktionova NA, Fang Q, Vankayala SL, Guida WC, Pegg AE. Substitution of aminomethyl at the meta-position enhances the inactivation of O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine. Journal of Medicinal Chemistry. 51: 7144-53. PMID 18973327 DOI: 10.1021/Jm800675P  0.74
2008 Lawrence HR, Pireddu R, Chen L, Luo Y, Sung SS, Szymanski AM, Yip ML, Guida WC, Sebti SM, Wu J, Lawrence NJ. Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds. Journal of Medicinal Chemistry. 51: 4948-56. PMID 18680359 DOI: 10.1021/Jm8002526  0.399
2008 Ma Y, Kurtyka CA, Boyapalle S, Sung SS, Lawrence H, Guida W, Cress WD. A small-molecule E2F inhibitor blocks growth in a melanoma culture model. Cancer Research. 68: 6292-9. PMID 18676853 DOI: 10.1158/0008-5472.Can-08-0121  0.353
2008 Brooks WH, Daniel KG, Sung SS, Guida WC. Computational validation of the importance of absolute stereochemistry in virtual screening. Journal of Chemical Information and Modeling. 48: 639-45. PMID 18266348 DOI: 10.1021/Ci700358R  0.387
2007 Brooks WH, McCloskey DE, Daniel KG, Ealick SE, Secrist JA, Waud WR, Pegg AE, Guida WC. In silico chemical library screening and experimental validation of a novel 9-aminoacridine based lead-inhibitor of human S-adenosylmethionine decarboxylase. Journal of Chemical Information and Modeling. 47: 1897-905. PMID 17676832 DOI: 10.1021/Ci700005T  0.405
2007 Siddiquee K, Zhang S, Guida WC, Blaskovich MA, Greedy B, Lawrence HR, Yip ML, Jove R, McLaughlin MM, Lawrence NJ, Sebti SM, Turkson J. Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proceedings of the National Academy of Sciences of the United States of America. 104: 7391-6. PMID 17463090 DOI: 10.1073/Pnas.0609757104  0.328
2006 Chen L, Sung SS, Yip ML, Lawrence HR, Ren Y, Guida WC, Sebti SM, Lawrence NJ, Wu J. Discovery of a novel shp2 protein tyrosine phosphatase inhibitor. Molecular Pharmacology. 70: 562-70. PMID 16717135 DOI: 10.1124/Mol.106.025536  0.39
2005 Guida WC, Hamilton AD, Crotty JW, Sebti SM. Protein farnesyltransferase: flexible docking studies on inhibitors using computational modeling. Journal of Computer-Aided Molecular Design. 19: 871-85. PMID 16607571 DOI: 10.1007/S10822-005-9030-2  0.396
2004 Smith DM, Daniel KG, Wang Z, Guida WC, Chan TH, Dou QP. Docking studies and model development of tea polyphenol proteasome inhibitors: applications to rational drug design. Proteins. 54: 58-70. PMID 14705024 DOI: 10.1002/Prot.10504  0.421
2003 Cheltsov AV, Guida WC, Ferreira GC. Circular permutation of 5-aminolevulinate synthase: effect on folding, conformational stability, and structure. The Journal of Biological Chemistry. 278: 27945-55. PMID 12736261 DOI: 10.1074/Jbc.M207011200  0.331
2003 Price ML, Guida WC, Jackson TE, Nydick JA, Gladstone PL, Juarez JC, Doñate F, Ternansky RJ. Design of novel N-(2,4-dioxo-1,2,3,4-tetrahydro-thieno[3,2-d]pyrimidin-7-yl)-guanidines as thymidine phosphorylase inhibitors, and flexible docking to a homology model. Bioorganic & Medicinal Chemistry Letters. 13: 107-10. PMID 12467627 DOI: 10.1016/S0960-894X(02)00828-4  0.369
1999 Kolossv�ry I, Guida WC. Low-mode conformational search elucidated: Application to C39H80 and flexible docking of 9-deazaguanine inhibitors into PNP Journal of Computational Chemistry. 20: 1671-1684. DOI: 10.1002/(Sici)1096-987X(19991130)20:15<1671::Aid-Jcc7>3.0.Co;2-Y  0.311
1997 Erion MD, Stoeckler JD, Guida WC, Walter RL, Ealick SE. Purine nucleoside phosphorylase. 2. Catalytic mechanism Biochemistry. 36: 11735-11748. PMID 9305963 DOI: 10.1021/Bi961970V  0.319
1995 Babu YS, Ealick SE, Bugg CE, Erion MD, Guida WC, Montgomery JA, Secrist JA. Structure-based design of inhibitors of purine nucleoside phosphorylase. Acta Crystallographica. Section D, Biological Crystallography. 51: 529-35. PMID 15299840 DOI: 10.1107/S0907444994011704  0.316
1994 Guida WC, Elliott RD, Thomas HJ, Secrist JA, Babu YS, Bugg CE, Erion MD, Ealick SE, Montgomery JA. Structure-based design of inhibitors of purine nucleoside phosphorylase. 4. A study of phosphate mimics. Journal of Medicinal Chemistry. 37: 1109-14. PMID 8164252 DOI: 10.1021/Jm00034A008  0.359
1994 Gonnella NC, Zhang X, Jin Y, Prakash O, Paris CG, Kolossváry I, Guida WC, Bohacek RS, Vlattas I, Sytwu T. Solvent effects on the conformation of cyclo(-D-Trp-D-Asp-Pro-D-Val-Leu-). An NMR spectroscopy and molecular modeling study. International Journal of Peptide and Protein Research. 43: 454-62. PMID 8070969 DOI: 10.1111/J.1399-3011.1994.Tb00544.X  0.306
1994 Guida WC. Software for structure-based drug design Current Opinion in Structural Biology. 4: 777-781. DOI: 10.1016/S0959-440X(94)90179-1  0.325
1993 Secrist JA, Niwas S, Rose JD, Babu YS, Bugg CE, Erion MD, Guida WC, Ealick SE, Montgomery JA. Structure-based design of inhibitors of purine nucleoside phosphorylase. 2. 9-Alicyclic and 9-heteroalicyclic derivatives of 9-deazaguanine. Journal of Medicinal Chemistry. 36: 1847-54. PMID 8515423 DOI: 10.1021/Jm00065A007  0.376
1993 Montgomery JA, Niwas S, Rose JD, Secrist JA, Babu YS, Bugg CE, Erion MD, Guida WC, Ealick SE. Structure-based design of inhibitors of purine nucleoside phosphorylase. 1. 9-(arylmethyl) derivatives of 9-deazaguanine. Journal of Medicinal Chemistry. 36: 55-69. PMID 8421291 DOI: 10.1021/Jm00053A008  0.402
1993 Bugg CE, Ealick SE, Montgomery JA, Secrist JA, Babu YS, Erion MD, Guida WC. The structure of human purine nucleoside phosphorylase and its use in inhibitor design Acta Crystallographica Section a Foundations of Crystallography. 49: c157-c157. DOI: 10.1107/S0108767378095513  0.303
1992 Guida WC, Bohacek RS, Erion MD. Probing the conformational space available to inhibitors in the thermolysin active site using Monte Carlo/energy minimization techniques Journal of Computational Chemistry. 13: 214-228. DOI: 10.1002/Jcc.540130213  0.317
1991 Ealick SE, Babu YS, Bugg CE, Erion MD, Guida WC, Montgomery JA, Secrist JA. Application of crystallographic and modeling methods in the design of purine nucleoside phosphorylase inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 88: 11540-4. PMID 1763067 DOI: 10.1073/Pnas.88.24.11540  0.37
1991 Secrist JA, Montgometry JA, Ealick SE, Bugg CE, Babu S, Erion MD, Guida WC. Structure-based drug design: Inhibitors of purine nucleoside phosphorylase (PNP) Antiviral Research. 15: 106. DOI: 10.1016/0166-3542(91)90204-5  0.342
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